49th week of 2011 patent applcation highlights part 41 |
Patent application number | Title | Published |
20110300579 | METHOD OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES WITH ENHANCED YIELDS AND ACTIVITY - Provided herein are methods for expressing proteins with disulfide bridges such as Vicrostatin (VCN), a chimeric variant of native snake venom disintegrin Contortrostatin (CN). The methods include what is believed to be a more efficient natural selection process that results in generating increased amounts of correctly-folded active conformers of proteins with disulfide bridges. In an aspect, this is achieved by growing Origami B cells in a more optimal redox environment during the induction of heterologous recombinant protein production. | 2011-12-08 |
20110300580 | Selection of host cells expressing protein at high levels - Described is a DNA molecule comprising an open reading frame sequence that encodes a selectable marker polypeptide, wherein the DNA molecule in the coding strand comprises a translation start sequence for the selectable marker polypeptide having a GTG start codon or a TTG start codon, and wherein the ORF sequence that encodes the selectable marker protein has been mutated to replace at least half of its CpG dinucleotides as compared to the native ORF sequence that encodes the selectable marker protein. Further provided are such DNA molecules wherein the ORF sequence that encodes a selectable marker polypeptide is part of a multicistronic transcription unit that further comprises an open reading frame sequence encoding a polypeptide of interest. Also described are methods for obtaining host cells expressing a polypeptide of interest, wherein the host cells comprise the DNA molecules described herein. Further provided is the production of polypeptides of interest, comprising culturing host cells comprising the DNA molecules described herein. | 2011-12-08 |
20110300581 | PROCESS FOR PRODUCING DIFRUCTOSE DIANHYDRIDE III CRYSTALS - A process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1,2′ and 2,3′ (di-D-fructofuranose-1,2′:2,3′-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH 5 to 8, and more preferably 6 to 8. DFA III can be produced industrially without lowering the crystal yield even when the crystallization thereof is done in a recycling system; additionally by adjusting the total fructose content in mother solutions for (crude) crystallization to 5% or less per a solid content basis and adjusting the fructose content to 1% or less, DFA III can more effectively be produced. | 2011-12-08 |
20110300582 | Corynebacteria Strain Having Enhanced 5'-Xanthosine Monophosphate Productivity and a Method of Producing 5'-Xanthosine Monophosphate Using the Same - Disclosed is a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type. Also, a recombinant vector which has the structure shown in the cleavage map of FIG. | 2011-12-08 |
20110300583 | IN VITRO RECOMBINATION METHODS USING 5' EXONUCLEASE - Provided herein is a method for homologous end cloning using a 5′-exonuclease. One aspect provides a method of generating a recombinant DNA molecule comprising 5′ exonuclease digestion of DNA molecules, exonuclease inactivation, annealing of 3′ overhangs to form a annealed complex. Also provided is a method a method of generating a recombinant DNA molecule comprising 5′ exonuclease digestion of DNA molecules, exonuclease inactivation, annealing of 3′ overhangs to form a annealed complex, and extension of 3′ ends to fill gaps corresponding to exonuclease removal to form a substantially non-gapped annealed complex. Also provided is a one reaction method in which no further additions need be made to the reaction mixture and the reaction mixture is only manipulated thereafter as to incubation time and incubation temperature. Complexes formed according to methods described herein can be transformed into a host cell without further in vitro processing. | 2011-12-08 |
20110300584 | SYNTHESIS OF FUCOSYLATED COMPOUNDS - A method for making a genetically modified cell having the ability to produce fucosylated compounds comprising the steps of
| 2011-12-08 |
20110300585 | Systems And Methods For Altering Rates Of Enzymatic Processes - The various embodiments of the present invention relate generally to compositions, systems, and methods for altering rates of catalysis. More particularly, the various embodiments of the present invention are directed toward compositions, systems, and methods for enzymatic hydrolysis of polysaccharides, such as cellulose and starch. An aspect of the present invention comprises a method for altering the rate of conversion of a substrate into a product comprising: providing a substrate in a carrier; mixing a reactant and a co-factor with the carrier to form a substantially homogeneous mixture of the reactant, the co-factor, and the substrate in the carrier; and reacting the reactant with the substrate in the presence of the co- factor to convert at least a portion of the substrate into the product, wherein the reaction rate of the reactant with the substrate in the presence of the co-factor is different than the reaction rate of the reactant with the substrate in the absence of the co-factor. | 2011-12-08 |
20110300586 | Two-Stage Process for Biomass Pretreatment - Described herein are improved methods of pretreating lignocellulosic biomass. One aspect of the invention relates to a two-stage pretreatment process comprising a relatively low severity steam treatment, a controlled pH pretreatment, or autohydrolysis, followed by hydrolysis with dilute acid or hot water at a relatively low temperature. In certain embodiments, the methods increase hemicellulose sugar yields, substrate digestibility, and suitability for fermentation as compared to steam explosion or acid hydrolysis alone. The two-stage pretreatment processes also employ few chemicals, minimizing the costs associated with pretreatment of lignocellulosic biomass. Moreover, the two-stage pretreatment process may expand the range of suitable feedstocks for bioethanol production. | 2011-12-08 |
20110300587 | Methods To Degrade Sludge From Pulp And Paper Manufacturing - A method to degrade or digest sludge, such as from pulp and/or paper manufacturing, is described. Compositions to use in the method are further described. | 2011-12-08 |
20110300588 | MUTATIONS AND GENETIC TARGETS FOR ENHANCED L-TYROSINE PRODUCTION - The invention relates to identification of mutations and genetic targets for enhanced L-tyrosine production, and bacterial strains capable of L-tyrosine production. | 2011-12-08 |
20110300589 | Novel Microbial Succinic Acid Producers and Purification of Succinic Acid - The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography. | 2011-12-08 |
20110300590 | Method for Synthesizing an Omega-Amino Acid or Ester from a Monounsaturated Fatty Acid or Ester - The invention relates to a method for synthesizing ω-aminoalkanoic acids or esters thereof from unsaturated natural fatty acids, passing through a monounsaturated dinitrile intermediate compound. The method of the invention is simple to carry out and, compared to other known methods, avoids the environmental constraints and economic disadvantages due to reaction by-products. | 2011-12-08 |
20110300591 | Bacterial Compositions of Staphylococcus Vitulinus Having Nitrate Reductase Activity and of Lactic Acid Bacteria and Methods Using These Compositions - The invention relates to a method for converting nitrates to nitrites and to specific compositions of bacteria belonging to the | 2011-12-08 |
20110300592 | METHOD FOR PRODUCING POLY-3-HYDROXYALKANOIC ACID - When industrially separating and purifying poly-3-hydroxyalkanoic acid produced by a microorganism, to obtain poly-3-hydroxyalkanoic acid particles having an arbitrary volume mean particle diameter with favorable productivity and with decreased amount of an organic solvent used is enabled while decreasing contaminants derived from constitutive components of cellular bodies. According to the present invention, aggregated matter of poly-3-hydroxyalkanoic acid is obtained by adjusting the amount of organic nitrogen in an aqueous suspension containing poly-3-hydroxyalkanoic acid to not greater than 1,500 ppm per weight of poly-3-hydroxyalkanoic acid; and thereafter allowing poly-3-hydroxyalkanoic acid to be aggregated in the aqueous suspension. | 2011-12-08 |
20110300593 | OPTIMISED FERMENTATION MEDIA - The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of a substrate comprising CO. It more particularly relates to the provision of an inorganic organic sulfur source to a fermentation system such that one or more micro-organisms convert a substrate comprising CO to alcohols. In a particular embodiment, a microbial culture is provided with sodium polysulfide, wherein a substrate comprising CO is converted to products including ethanol and 2,3-butanediol. | 2011-12-08 |
20110300594 | PROCESS FOR MAKING LINEAR DICARBOXYLIC ACIDS FROM RENEWABLE RESOURCES - This invention provides a process of making a linear dicarboxylic acid of C | 2011-12-08 |
20110300595 | MICROORGANISM FOR PRODUCING SUCCINIC ACID - The invention relates to an isolated, genetically modified microorganism, wherein compared to the wild type a) the idh1 and idp1 genes have been deleted or inactivated, and/or b) the sdh2 and sdh1 genes have been deleted or inactivated, and/or c) the PDC2 gene has been deleted or inactivated or is under the control of a promoter which can be suppressed or induced by exposure of the microorganism using an inductor substance, and/or d) one or more genes from the group consisting of ICL1, MLS1, ACS1 and MDH3 has been replaced or supplemented by a corresponding foreign gene or corresponding foreign genes from Crabtree-negative organisms, and to the uses thereof. | 2011-12-08 |
20110300596 | PREPARATION METHOD FOR ALCOHOL FROM CARBOXYLIC ACID BY ONE-STEP PROCESS - The present invention relates to a preparation method for alcohol by reacting carboxylic acid, alcohol, and hydrogen using hydrogenation catalysts. More specifically, the invention relates to a method for preparing alcohol by performing esterification and hydrocracking in a one-step process using hydrogenation catalysts instead of a two-step process. According to the invention, alcohol is prepared from carboxylic acid through esterification and hydrogenation in a one-step process using hydrogenation catalysts. Therefore, production costs and by-product treatment costs can be reduced in comparison to a two-step process. In addition, the invention is effective and economical since it can produce alcohol at relatively high yield by a simple process. Further, the invention allows high yield at relatively lower pressure when compared to alcohol production from carboxylic acid through hydrogenation without esterification and solves the problems of leaching by catalysts. | 2011-12-08 |
20110300597 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE - The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene. | 2011-12-08 |
20110300598 | Device and Method Using Integrated Neuronal Cells and an Electronic Device - The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same. | 2011-12-08 |
20110300599 | METHODS FOR IMPROVING THE BIOACTIVITY CHARACTERISTICS OF A SURFACE AND OBJECTS WITH SURFACES IMPROVED THEREBY - The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provides a method of attaching cells to an object. The invention even further provides for a method of preparing an object for medical implantation. The invention also provides for an article with attached cell, and for an article for medical implantation. Improvements result from the application of gas-cluster ion beam technology and from the application of neutral beam technology, wherein neutral beams are derived from accelerated gas-cluster ion beams. | 2011-12-08 |
20110300600 | METHODS AND COMPOSITIONS FOR DELIVERING POLYNUCLEOTIDES - Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided. | 2011-12-08 |
20110300601 | PROCESSES FOR SYNTHESIZING ALKALINE PHOSPHATASE CONJUGATES - Methods for synthesizing an ALP conjugate are provided. The methods may include activating a carboxyl group of the ALP with a carbodiimide, to generate an active ester; and adding the substance to be conjugated such that a synthetic reaction occurs between the active ester and the substance to be conjugated, to generate an ALP conjugate. | 2011-12-08 |
20110300602 | CONJUGATE PREPARATION METHODS AND RELATED KIT - Methods for preparing conjugates including enzyme conjugates and especially alkaline phosphatase (ALP) conjugates, and a kit are provided. The methods include: blocking an amino group on a molecule surface of a first substance to be conjugated containing an amino group and a carboxyl group (for example, an enzyme) with a carboxyl compound; adding a carbodiimide to activate the first substance to be conjugated with the amino group blocked; inactivating or removing the carbodiimide; and adding a second substance containing an amino group (for example, a substance to be labeled). Conjugates (for example, enzyme conjugates) are obtained. | 2011-12-08 |
20110300603 | Tagged Ligands for Enrichment of Rare Analytes from a Mixed Sample - Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular marker of the rare cells and the affinity tag can be selectively captured by a capture moiety, wherein the affinity tags do not comprise a magnetic particle; and flowing the sample through a microfluidic device comprising the capture moiety to selectively retain ATL-bound cells. Methods for enriching circulating tumor cells, and devices for enriching specific cells from cellular samples are also disclosed. | 2011-12-08 |
20110300604 | RECOMBINANT INFLUENZA VECTORS WITH TANDEM TRANSCRIPTION UNITS - The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include tandem transcription cassettes containing PolI and/or PolII promoters. | 2011-12-08 |
20110300605 | NANOSCALING ORDERING OF HYBRID MATERIALS USING GENETICALLY ENGINEERED MESOSCALE VIRUS - The present invention includes methods for producing nanocrystals of semiconductor material that have specific crystallographic features such as phase and alignment by using a self-assembling biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to semi-conductor material. One form of the present invention is a method to construct ordered nanoparticles within the liquid crystal of the self-assembling biological molecule. | 2011-12-08 |
20110300606 | FORMULA OF MEDIUM FOR CULTURING CORDYCEPS SPP. - A formula of medium for culturing | 2011-12-08 |
20110300607 | System for Treating Blood of Slaughtered Animals and Method for Producing High-Quality Amino Acid Solution Using Blood of Slaughtered Animals - The present invention provides a system for treating the blood of slaughtered animals, the system comprising: a storage tank for collecting and storing the blood of animals slaughtered in a slaughter plant; a blood treatment tank in which the animal blood is received and stored from the blood storage tank and into which a liquid microbial agent for treating blood is introduced so that microorganisms of the liquid microbial agent are allowed to react at a temperature of 25˜35° C. for 8-12 hours, thereby separating the animal blood into an amino acid solution and a waste blood sludge; a blood-treating agent supply unit for supplying the liquid microbial agent to the blood treatment tank; a water supply unit for supplying water to the blood treatment tank; a filtering means for filtering the amino acid solution discharged from the blood treatment tank to remove impurities; a heater for maintaining the blood treatment tank at a temperature of 25˜35° C.; and a temperature sensor for sensing the internal temperature of the blood treatment tank. According to the invention, microorganisms are used to degrade waste animal blood and produce high-quality environmentally friendly amino acids, thereby providing the effects of recycling resources and preventing environmental contamination. | 2011-12-08 |
20110300608 | NUCLEIC ACID ISOLATION IN PRESERVED WHOLE BLOOD - A method for isolating nucleic acids is disclosed, wherein a sample having nucleic acid containing starting material is fixed, lysed, and treated to remove unwanted contaminants. The initial fixing of the sample aids in maintaining the structure and integrity of the isolated DNA and reduces the incidence of end product contaminants and DNA shearing. | 2011-12-08 |
20110300609 | NUCLEIC ACID EXTRACTION APPARATUS - The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel supporting member that is provided inside the tube and filters impurities excluding an extraction target material. | 2011-12-08 |
20110300610 | Thermally Conductive Microplate - Embodiments according to the present teachings of a microplate comprising a main body portion having a first surface and an opposing second surface are disclosed. A plurality of wells are formed in the first surface, each of the plurality of wells being sized to receive an assay therein. A backing is coupled to the opposing second surface of the main body portion. | 2011-12-08 |
20110300611 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 2011-12-08 |
20110300612 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 2011-12-08 |
20110300613 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 2011-12-08 |
20110300614 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 2011-12-08 |
20110300615 | Apparatus and method for maintaining and/or restoring viability of organs - An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. | 2011-12-08 |
20110300616 | METHOD FOR CREATING PERFUSABLE MICROVESSEL SYSTEMS - A method for the creation of endothelial parent vessels from human vascular endothelial cells in vitro in a culture perfusion device (CPD) including a collagen chamber, inlet ports, a capillary tube, and an outlet port. A collagen solution is injected into the collagen chamber through a syringe needle until the chamber is filled with collagen. The CPD is perfused by filling the inlet ports and sequentially priming the inlet ports, and the outlet ports. A perfusable channel is created in the collagen chamber and a concentrated suspension of endothelial cells is injected into the inlet ports. The endothelial cells are injected into the at least one perfusable channel and incubated to attach to the walls of the perfusable channel. The cells are distributed within the CPD; and perfused to form a parent vessel having homogeneous monolayers of cells. | 2011-12-08 |
20110300617 | BIOMASS HYDROTHERMAL DECOMPOSITION APPARATUS, TEMPERATURE CONTROL METHOD THEREOF, AND ORGANIC RAW MATERIAL PRODUCTION SYSTEM USING BIOMASS MATERIAL - A biomass hydrothermal decomposition apparatus that feeds a solid biomass material | 2011-12-08 |
20110300618 | SEMI-AUTOMATED DEVICE FOR SINGLE PARAMETER AND MULTI-PARAMETER PHENOTYPING OF CELLS - A single-use device that produces a readily interpretable, visual presentation of biomaterial, enabling single parameter and multi-parameter characterizing of said biomaterial by means of visual inspection, particularly for immunophenotyping. In one embodiment, the device uses antibody coated microspheres which are adapted to bind to specific types of cells. An arrangement of uniquely molded components, which may be plastic or other suitable material, are assembled so as to provide a sequential procedure capable of incubating a suspension comprised of antibody coated microspheres, biomaterial, and liquid suspension agents. Following incubation, the invention further removes liquids from said suspension, and provides for rinsing the incubated retentate and for removing said rinsing liquids from the incubated retentate. The invention further provides for affixing the incubated retentate onto a standard glass microscope slide to enable phenotyping of incubated biomaterial (e.g., cells) by means of visual inspection or other analyses that can be performed from a glass slide. | 2011-12-08 |
20110300619 | IN VITRO DETERMINATION OF ANALYTE LEVELS WITHIN BODY FLUIDS - A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band. | 2011-12-08 |
20110300620 | Combo-tip Rack - The invention relates to a three-part rack for holding re-usable pipette tips. The rack comprises an upper, a lower and an insert rack. The rack is optimized for holding first and second types of pipette tips, and comprises contamination protection. | 2011-12-08 |
20110300621 | Process head positioning - A method is disclosed for mechanically aligning a process device and a rack which comprises mechanical engagement of positioning elements on the process device and positioning elements on the consumable. | 2011-12-08 |
20110300622 | Apparatus and Method for Transporting Sample Well Trays - An apparatus for transporting sample well trays with respect to a heating device is provided. The apparatus includes a sample well tray holder, a rotational actuator, and a biasing mechanism. The sample well tray holder includes a plate in which a sample well tray may be positioned. The sample well tray holder is configured to rotate about a first rotational axis. The rotational actuator is configured to rotate the sample well tray holder about the first rotational axis. The biasing mechanism is configured to urge the sample well tray holder in a generally upward direction along the first rotational axis. | 2011-12-08 |
20110300623 | PROCESS FOR ACCELERATED CAPTURE OF CARBON DIOXIDE - The present invention generally relates to the removal of carbon dioxide from a gas stream, particularly a flue gas, hydrogen gas from a reformer, natural gas, or gas from a cement kiln. Immobilized enzymes for use in carbon capture and other systems are also disclosed. | 2011-12-08 |
20110300624 | PHOTOBIOREACTOR - A photobioreactor ( | 2011-12-08 |
20110300625 | TISSUE FOR PROSTHETIC IMPLANTS AND GRAFTS, AND METHODS ASSOCIATED THEREWITH - A prepared tissue for medical use with a patient is provided. Methods for preparing such tissue are also provided. Implantable tissue is provided by harvesting a tissue, such as but not limited to a pericardium tissue, and exposing the tissue to various cleaning, rinsing, treatment, separating, and fixation steps. The tissue of at least one embodiment is cleaned with distilled water, rinsed with isopropyl alcohol, and treated with a glutaraldehyde solution. The prepared tissue may be allowed to dry or partially hydrated prior to packaging and shipment. As such, the tissue can be implanted into the receiving patient in either a dry or wet state. The relatively thin yet strong tissue material is adapted for implanting within or grafting to human tissue. By way of example, the tissue may be used in a shunt, a valve, as graft material, as a patch, as a prosthetic tissue in a tendon and/or ligament, and a tissue product for wound management. | 2011-12-08 |
20110300626 | Electrospun Ceramic-Polymer Composite As A Scaffold for Tissue Repair - The present invention relates to compositions and methods of preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a bioactive ceramic component and a polymer component. The matrix provides an osteoconductive and osteoinductive scaffold supporting osteogenesis and thereby facilitates bone repair. | 2011-12-08 |
20110300627 | DEDIFFERENTIATION AND REPROGRAMMING OF CELLS - The invention is directed to methods for reprogramming somatic cells to a less differentiated state. In particular, the invention is directed to methods for reprogramming amnion epithelial cells (AEC) including amnion-derived cells (ADC) and Amnion-derived Multipotent Progenitor cells (AMP cells) to a less differentiated state. The invention is further directed to compositions comprising reprogrammed AEC, ADC and AMP cells, and uses thereof. | 2011-12-08 |
20110300628 | ENHANCEMENT OF EPIDERMAL CELL GROWTH BY NON-PROTEIN GROWTH FACTORS - The serum-free culture of normal human epithelial stem cells is of paramount importance for the in vitro formation of cloned human tissues by means of cell therapy. Several growth promoting agents are disclosed for use in a serum-free culture medium of normal human keratinocytes. Lithium ions, dibutryl-cyclic adenosine monophosphate, and prostaglandin E1 have been found effective as growth enhancing agents to be added singly or in combination, when used in combination with insulin-like growth factor-1. Lithium ions and prostaglandin E1 are disclosed as independent growth enhancing factors, that replace epidermal growth factor as a necessary growth factor required for keratinocyte clonal growth. | 2011-12-08 |
20110300629 | TRAIL trimers, methods and uses therefor - Disclosed are TNF-related apoptosis-inducing ligand (TRAIL) trimers (TR3) and nucleic acids encoding covalently linked TRAIL trimers. A TRAIL trimer can have greater stability compared to native TRAIL, and can retain the native killing ability of TRAIL. Target specificity of a TR3 can be shown by blocking its activity with soluble death receptor 5 (DR5-Fc). Also disclosed are modified TRAIL trimers and nucleic acids encoding them. These modifications include additional functional domains, such as antibody fragments (scFvs). A TR3 comprising an additional functional domain can allow for cell-specific delivery of the TR3. In some configurations, a modification such as the addition of a functional domain can be stoichiometrically controlled. In some configurations, a modification can be inconsequential with regard to the bioactivity of TRAIL. In various embodiments, a TR3, including a modified TR3, can be a cancer-selective drug. In some configurations, a TR3 that comprises an additional biologically active moiety such as a functional domain of a protein can have fewer off-target toxicities compared to TRAIL alone. In some configurations, a TR3 that comprises an additional biologically active moiety such as a functional domain of a protein can have enhanced killing capacities compared to the moiety alone. In some aspects, TR3 activity can be targeted to an RBC membrane. The inventors disclose TR3-decorated RBCs that target cell killing in a model of pancreatic cancer. | 2011-12-08 |
20110300630 | METHODS FOR TREATING DEGENERATIVE DISEASES/INJURIES - Invented is a method of treating degenerative diseases/injuries, in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide TPO receptor agonist to such mammal. | 2011-12-08 |
20110300631 | METHOD FOR SUPPRESSING CELL GROWTH - Disclosed is a method for suppressing the growth of a target cell, which is not limited in the type of a target cell and the type of a protein to be expressed in the target cell and needs not any preparatory experiment for determining a codon to be contained in a protein to be expressed in a target cell. Specifically disclosed is a method for suppressing the growth of a target cell, which comprises the steps of: incorporating DNA containing a region encoding a protein into the target cell, and allowing a protein encoded by the DNA to be expressed in the target cell into which the DNA has been incorporated. The region contained in the DNA comprises a tri-nucleotide sequence. The tri-nucleotide sequence is selected from codons that define at least some amino acid species constituting the protein, and is complementary to at least some codons that are used in the target cell at a frequency of 0.2 or less. | 2011-12-08 |
20110300632 | METHOD OF DIRECTING THE EVOLUTION OF AN ORGANISM - The present disclosure relates to a method of directing the evolution of an organism by modifying the mutation rate of an organism. The increase in genetic diversity may be used to facilitate the selection of a desired hereditary trait in an organism. | 2011-12-08 |
20110300633 | NOVEL PROMOTER FOR USE IN TRANSFORMATION OF ALGAE - The objective of the present invention is to provide a transformation method that is applicable to a wide variety of species of algae with high efficiency. The promoter of the present invention is characterized in containing a polynucleotide constituting a non-coding region located upstream from a gene encoding a replication-associated protein of a CdebDNA virus or the like. | 2011-12-08 |
20110300634 | Method for Determining Chromium Content in a Tungsten Matrix with Added Chromium or Simultaneously Added Chromium and Vanadium - A method for determining chromium content in a tungsten matrix with singly or simultaneously added chromium and vanadium, characterized in that a test sample is subjected to melting with sodium peroxide and hot water leaching; meanwhile said sodium peroxide is also used as an oxidizing agent to oxidize all the chromium to high valences; the main body of tungsten is coordinated by ammonium hydrogen fluoride to prevent tungstic acid from precipitating; precipitation and turbidity are avoided throughout the analysis, titration can be carried out in a quite clear condition with accurate and reliable results. In this invention, the clearness of the solution when titrating is very important for the accuracy of titrimetric analysis; the solution is always clear throughout the determination, ensuring that the interference with determination of chromium from vanadium is accurately and quantitatively eliminated; the interference from vanadium is eliminated by subtraction method, by means of titrating with ferrous ammonium sulfate standard solution after oxidation with potassium permanganate. In this invention, the determination method allows the determination to be carried out in the quite clear condition, and eliminates the interference from vanadium completely and quantitatively, thus the accuracy and speed of the determination of chromium content in a tungsten matrix with singly or simultaneously added chromium and vanadium are improved. | 2011-12-08 |
20110300635 | CHEMICAL INDICATOR TEST STRIP - Articles and methods for the detection and/or quantification of organic analytes are described. The invention provides a chemical indicator test strip, comprising: a substrate; and a coating comprising a leuco dye complex on the substrate, the coating being insoluble in water and reactive with an organic analyte, the coating derived from a solution of leuco dye and developing agent. In another aspect, the coating further comprises adjuvant, in the form of a water-insoluble, polar, hydrophobic, aprotic material that extends the lower limit of detection for the analyte. In still another aspect, the present invention provides a method of using a chemical indicator test strip, comprising: (a) exposing the chemical indicator test strip to a sample comprising an organic analyte; (b) measuring a color change on the chemical indicator test strip following the exposing step; and (c) correlating the color change with the concentration of the analyte in the sample. | 2011-12-08 |
20110300636 | METHOD AND APPARATUS FOR DETECTING HYDROGEN PEROXIDE - The presence of hydrogen peroxide vapor is detected with high sensitivity. Oxygen molecules in the air are ionized by electrons generated by a discharge plasma, thereby producing an oxygen molecule negative ion O | 2011-12-08 |
20110300637 | Polyaniline Nanofiber Hydrogen Sensors - A method for sensing hydrogen includes the use of a transduction device with a sensing layer, and means for measuring a mass and/or conductivity change caused by an interaction of a gas with the sensing layer to provide a measure of an amount of hydrogen in the gas. The sensing layer includes polyaniline nanofiber material. | 2011-12-08 |
20110300638 | Ion Mobility Spectrometers - An ion mobility spectrometer has a reaction region separated from a drift region by an electrostatic gate. A doping circuit supplies a dopant to the reaction region but the drift region is undoped. Two high field ion modifiers are located one after the other in the drift region. One ion modifier can be turned on to remove dopant adducts from the admitted ions, or both ion modifiers can be turned on so that the ions are also fragmented. In this way, several different responses can be produced to provide additional information about the nature of the analyte substance and distinguish it from interferents. | 2011-12-08 |
20110300639 | Improved Sample Injection Port for Laminated Devices - Contemplated diagnostic test containers and methods include an adapter configured to sealingly receive and retain a positive displacement pipette tip to so form a fluid-tight seal for the container during at least part of the diagnostic test. Most preferably, the entire container is flexible and the container and adapter are single-use disposable and are usable with known commercially available positive displacement pipette tips. | 2011-12-08 |
20110300640 | METHOD AND DEVICE FOR AUTHENTICATING OBJECTS PROVIDED WITH A MARKER, THE SPECIFICATION OF WHICH: - The invention relates to a method for authenticating objects provided with a marker that contains nucleic acid. | 2011-12-08 |
20110300641 | PROTEIN ISOFORMS FOR DIAGNOSIS - Several aspects of this invention relate to diagnosis of diabetic states in a mammal using protein isoforms. In some aspects, it relates to a method for determining the diabetic state of a mammal. This method can include, for example, (a) measuring the serum concentration of one or more protein isoforms, (b) analyzing the serum concentration of the one or more protein isoforms, and (c) determining the diabetic state of the mammal. Other aspects include kits used to perform the method. Further aspects are the isolated protein isoforms themselves, and their methods of isolation. | 2011-12-08 |
20110300642 | METHODS FOR DIFFERENTIATING AND MONITORING PARATHYROID AND BONE STATUS RELATED DISEASES - The present invention relates to novel methods and devices for differentiating in a patient parathyroid diseases, such as hyperparathyroidism and related bone diseases, from normal or non-disease states. One detects whole or non-fragmented (1 to 84) parathyroid hormone in a biological sample and also a large non-whole parathyroid hormone peptide fragment that can function as a parathyroid hormone antagonist. By either comparing values or using independently the value of either the large non-whole parathyroid hormone peptide fragment, the whole parathyroid hormone, or the combination of these values, one is able to differentiate parathyroid and bone related disease states, as well as differentiate such states from normal states. | 2011-12-08 |
20110300643 | Method of assembling displays on substrates - Various embodiments of methods and systems for designing and constructing displays from multiple light-modulating elements are disclosed. Display elements having different light-modulating and self-assembling characteristics may be used during display assembly and operation. | 2011-12-08 |
20110300644 | METHOD FOR MANUFACTURING SEMICONDUCTOR LIGHT EMITTING DEVICE - According to one embodiment, a method for manufacturing a semiconductor light emitting device is disclosed. The method can include forming a first interconnect layer, a second interconnect layer, a first metal pillar, a second metal pillar, a second insulating layer, a transparent material and a phosphor layer. The transparent material is formed on the first major surface of a semiconductor layer selected from the plurality of semiconductor layers on the basis of an emission spectrum of a light obtained from the first major surface side. The transparent material transmits the light. The phosphor layer is formed on the transparent material and the first major surface of the plurality of the semiconductor layers. | 2011-12-08 |
20110300645 | APPARATUS AND METHOD FOR BATCH NON-CONTACT MATERIAL CHARACTERIZATION - An apparatus for performing non-contact material characterization includes a wafer carrier adapted to hold a plurality of substrates and a material characterization device, such as a device for performing photoluminescence spectroscopy. The apparatus is adapted to perform non-contact material characterization on at least a portion of the wafer carrier, including the substrates disposed thereon. | 2011-12-08 |
20110300646 | PATTERN FORMING METHOD, MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE, AND TEMPLATE MANUFACTURING METHOD - In the pattern forming method according to the embodiment, second templates are manufactured by an imprint technology using first templates manufactured by applying a predetermined misalignment distribution for each shot on a first substrate by an exposure apparatus. Then, an upper-layer-side pattern is formed by an imprint technology using a second template in which an inter-layer misalignment amount between a lower-layer-side pattern already formed above a second substrate and the upper-layer-side pattern to be formed above the second substrate becomes equal to or lower than a predetermined reference value. | 2011-12-08 |
20110300647 | METHOD FOR MANUFACTURING SEMICONDUCTOR CHIPS FROM A SEMICONDUCTOR WAFER - A method for manufacturing semiconductor chips from a semiconductor wafer, including the steps of: fastening, on a first support frame, a second support frame having outer dimensions smaller than the outer dimensions of the first frame and greater than the inner dimensions of the first frame; arranging the wafer on a surface of a film stretched on the second frame; carrying out wafer processing operations by using equipment capable of receiving the first frame; separating the second frame from the first frame and removing the first frame; and carrying out wafer processing operations by using equipment capable of receiving the second frame. | 2011-12-08 |
20110300648 | SUBSTRATE PROCESSING METHOD AND METHOD FOR MANUFACTURING LIQUID EJECTION HEAD - A substrate processing method including the steps of disposing a substrate having a recess in such a manner that the face having the recess is upward in the gravity direction, and applying a resist to the recess and face having the recess to form a resist film thereon, and disposing the substrate having the resist film formed thereon in such a manner that the face having the recess is downward in the gravity direction, and applying a liquid capable of dissolving the resist to the resist film to adjust the thickness of the resist film. A method for manufacturing a liquid ejection head is also provided. | 2011-12-08 |
20110300649 | PACKAGE FOR A LIGHT EMITTING DIODE AND METHOD FOR FABRICATING THE SAME - A method for fabricating a LED includes: providing a metal substrate; etching the metal substrate to form a first terminal, a second terminal, and a gap between the first terminal and the second terminal, wherein the first terminal has at least one first etching concave and the second terminal has at least one second etching concave; placing at least one LED chip in the at least one first etching concave, wherein the at least one LED chip has a first electrode and a second electrode; electrically connecting the first electrode with the first terminal, and electrically connecting the second electrode with the second terminal; and then covering the at least one LED chip with synthetic polymer, wherein the synthetic polymer is filled into the at least one first etching concave, the at least one second etching concave and the gap to connect the first terminal with the second terminal. | 2011-12-08 |
20110300650 | LIGHT-EMITTING DIODE APPARATUS AND MANUFACTURING METHOD THEREOF - A light-emitting diode (LED) apparatus includes a thermoconductive substrate, a thermoconductive adhesive layer, an epitaxial layer, a current spreading layer and a micro- or nano-roughing structure. The thermoconductive adhesive layer is disposed on the thermoconductive substrate. The epitaxial layer is disposed opposite to the thermoconductive adhesive layer and has a first semiconductor layer, an active layer and a second semiconductor layer. The current spreading layer is disposed between the second semiconductor layer of the epitaxial layer and the thermoconductive adhesive layer. The micro- or nano-roughing structure is disposed on the first semiconductor layer of the epitaxial layer. In addition, a manufacturing method of the LED apparatus is also disclosed. | 2011-12-08 |
20110300651 | METHOD FOR MANUFACTURING LIGHT-EMITTING DEVICE - According to one embodiment, a method for manufacturing a light-emitting device is disclosed. The method can include forming a first electrode and a second electrode on a semiconductor layer which is included in a first structure body, the semiconductor layer including a light-emitting layer on a substrate. The method can include forming a first metal pillar in conduction with the first electrode, and a second metal pillar in conduction with the second electrode. The method can include filling a region between the first metal pillar and the second metal pillar with an insulating layer. In addition, the method can include separating the substrate from the semiconductor layer, and forming a second structure body in which the semiconductor layer is supported by the insulating layer and which is convex toward an opposite side of the insulating layer to the semiconductor layer. | 2011-12-08 |
20110300652 | NITRIDE SEMICONDUCTOR LIGHT EMITTING DEVICE AND MANUFACTURING METHOD OF THE SAME - There is provided a nitride semiconductor light emitting device and a manufacturing method of the same. The nitride semiconductor light emitting device including: a substrate for growing a nitride single crystal, the substrate having electrical conductivity; a p-type nitride semiconductor layer formed on the substrate; an active layer formed on the p-type nitride semiconductor layer, the active layer including a plurality of quantum barrier layers and a plurality of quantum well layers deposited alternately on each other; an n-type nitride semiconductor layer formed on the active layer; a p-electrode formed on a bottom of the substrate; and an n-electrode formed on a top of the n-type nitride semiconductor layer. | 2011-12-08 |
20110300653 | METHOD OF FABRICATING GROUP-III NITRIDE SEMICONDUCTOR LASER DEVICE - A method for fabricating a III-nitride semiconductor laser device includes: forming a substrate product having a laser structure; scribing a first surface of the substrate product to form a scribed mark, which extends along a reference line indicative of a direction of the a-axis of the hexagonal III-nitride semiconductor, on the first surface, a scribed mark; mounting the substrate product on a breaking device to support first and second regions of the substrate product by first and second support portions, respectively, of the breaking device; and carrying out breakup of the substrate product by press in alignment with the scribed mark in a third region, without supporting the third region of the substrate product located between the first and second regions, to form another substrate product and a laser bar. First and second end faces of the laser bar form a laser cavity of the III-nitride semiconductor laser device. | 2011-12-08 |
20110300654 | Method of manufacturing semiconductor light emitting device - Provided is a method of manufacturing semiconductor light emitting devices including: forming light emitting structures by sequentially depositing a first material layer, an active layer and a second material layer; forming the roughness pattern on a region of the bottom of a substrate except at least a cleaving region for forming cleaving planes; and forming n-electrodes. | 2011-12-08 |
20110300655 | LIQUID CRYSTAL DISPLAY DEVICE HAVING A COMPOSITE DATA LINE WITH A LINE OPENING EXPOSING THE TOP SURFACE AND SIDEWALLS - An LCD device includes plurality of gate lines and data lines crossing each other to define pixel regions on a substrate. A thin film transistor (TFT) resides at a crossing portion of the gate lines and the data lines and a pixel electrode is electrically connected with the TFT. The TFT includes a gate electrode, a gate insulation layer on the gate electrode and a semiconductor layer on the gate insulation layer. A portion of the data line and the semiconductor layer form a composite layer between adjacent pixel electrodes in which a line width of data line is the same as a line width of semiconductor layer. A method of fabricating the LCD device includes etching a passivation layer using a mask pattern and etching the semiconductor layer using the mask pattern and a portion of the data line as an etch mask to form the composite layer. | 2011-12-08 |
20110300656 | METHODS FOR FORMING A PIXEL OF A LIGHT-EMITTING DIODE LIGHT SOURCE AND A PLURALITY OF LIGHT-EMITTING DIODE PIXELS ARRANGED IN A TWO-DIMENSIONAL ARRAY - A method for forming a pixel of an LED light source is provided. The method includes: forming a first layer on a first substrate; forming a second layer and a first light-emitting active layer on the first layer; forming a first intermediate layer on the second layer; forming a third layer on a second substrate; forming a fourth layer and a second light-emitting active layer on the third layer; placing the third layer, the fourth layer, and the second light-emitting active layer on the first intermediate layer, wherein the first light-emitting active layer and the second light-emitting active layer emit different colors of light. A method for forming a plurality of light-emitting diode pixels arranged in a two-dimensional array is also provided. | 2011-12-08 |
20110300657 | PROCESS FOR FORMING AN ELECTROACTIVE LAYER - There is provided a process for forming a layer of electroactive material. The process includes: depositing a liquid composition containing an electroactive material and at least one solvent onto a workpiece to form a wet layer; placing the wet layer on the workpiece into a vacuum chamber containing solid absorptive material; and treating the wet layer at a controlled temperature in the range of −25° C. to 80° C. and under an applied vacuum in the range of 10 | 2011-12-08 |
20110300658 | METHODS OF CREATING A MICRO ELECTRO-MECHANICAL SYSTEMS ACCELEROMETER USING A SINGLE DOUBLE SILICON-ON-INSULATOR WAFER - Methods for creating a microelectromechanical systems (MEMS) device using a single double, silicon-on-insulator (SOI) wafer. The double SOI wafer includes at least a base layer of silicon, a first layer of silicon, and a second layer of silicon, the layers of silicon are separated by an oxide layer. A stationary electrode with rigid support beams is formed into the second layer of silicon. A proof mass and at least one spring are formed into the first layer of silicon. The proof mass is separated from the stationary electrode by a first gap and the proof mass is separated from the base silicon layer by a second gap. | 2011-12-08 |
20110300659 | METHOD FOR FABRICATING MEMS DEVICE - Method for fabricating MEMS device has a first surface and a second surface and having a MEMS region and an IC region. A MEMS structure is formed over the first surface. A structural dielectric layer is formed over the first surface. The structural dielectric layer has a dielectric member and the spaces surrounding the MEMS structure is filled with the dielectric member. The substrate is patterned by etching process from the second surface of the substrate to expose a portion of the dielectric member filled in the space surrounding the MEMS structure. A wettable thin layer is formed to cover an exposed portion of the substrate at the second surface. An etching process is performed on the dielectric member filled in the spaces surrounding the MEMS structure. The MEMS structure is exposed and released by the etching process. The etching process comprises an isotropic etching process with a wet etchant. | 2011-12-08 |
20110300660 | METHOD OF MANUFACTURING PHOTOVOLTAIC DEVICE - Disclosed herein is a method of manufacturing a photovoltaic device. The method includes the steps of providing a front substrate and a back substrate, forming a photovoltaic cell on the front substrate, encapsulating the photovoltaic cell by an encapsulant, attaching a solid state sealant tape on one of the two substrates, and adhering the two substrates through the solid state sealant tape and the encapsulant. The solid state sealant tape is in solid state at room temperature. The photovoltaic cell and the encapsulant are situated within an enclosed space formed by the two substrates and the solid state sealant tape. | 2011-12-08 |
20110300661 | SOLAR CELL INTERCONNECTION METHOD USING A FLAT METALLIC MESH - An improved method for interconnecting thin film solar cells to form solar cell modules is provided, the method comprising using a flat metallic mesh formed from a thin metallic strip to provide a current collection grid over a thin film solar cell. The method is particularly useful for forming interconnections between thin film solar cells deposited on flexible substrates. The rectangular cross sectional shape of the mesh elements provides an increased area of electrical contact to the solar cell compared to the small tangential area provided by elements of circular cross section. Mesh elements can be made higher rather than wider to improve conductivity without proportionally increasing shading loss. Various coatings can be applied to the mesh to improve its performance, provide corrosion resistance, and improve its cosmetic appearance. | 2011-12-08 |
20110300662 | METHOD OF FORMING PATTERN AND METHOD OF PRODUCING SOLID-STATE IMAGE PICKUP DEVICE - Provided is a method of forming a pattern including the steps of forming a first pattern including a depressed or protruding alignment mark on a substrate; forming a flattening layer on the first pattern; removing a part of the flatting layer above the alignment mark; forming a processed layer on the flattening layer to cover the alignment mark; performing alignment by optically detecting a position of the alignment mark from above the processed layer, using light; and forming a second pattern by patterning the processed layer on the basis of the alignment. | 2011-12-08 |
20110300663 | Method of manufacturing a monolithic thin-film photovoltaic device with enhanced output voltage - The invention provides a method of manufacturing a monolithic thin-film photovoltaic cell or module with enhanced output voltage as high as 100 V or higher in a single microelectronic process without connecting in series a plurality of premanufactured solar cells. The method consists of forming a plurality of adjacent individual TSCs arranged on a common transparent substrate in the longitudinal direction of the substrate. Each TSC consists of a pair of PV cells having PIN and NIP structures, respectively, with substantially coplanar position of a P-doped layer of one of the cells with respect to an N-doped layer of another cell of the pair. A tunnel junction is formed between the cells of the pair by overlapping P-doped and N-doped layers in the area near the common transparent substrate. The alternating PIN and NIP structures are achieved by forming projections in a continuous monolithic structure of one type and filling the spaces between the projections with the material of the inverse structure of the other type. | 2011-12-08 |
20110300664 | SOLAR CELL INTERCONNECTION, MODULE AND PANEL METHOD - A laminated module or panel of solar cells and a laminating method for making same comprise a top layer of melt flowable optically transparent molecularly flexible thermoplastic and a rear sheet of melt flowable insulating molecularly flexible thermoplastic both melt flowing at a temperature between about 80° C. and 250° C. and having a low glass transition temperature. Solar cells are encapsulated by melt flowing the top layer and rear sheet, and electrical connections are provided between front and back contacts thereof. Light passing through the transparent top layer impinges upon the solar cells and the laminated module exhibits sufficient flexural modulus without cross-linking chemical curing. Electrical connections may be provided by melt flowable electrically conductive molecularly flexible thermoplastic adhesive or by metal strips or by both. | 2011-12-08 |
20110300665 | Ablation Of Film Stacks In Solar Cell Fabrication Processes - A dielectric film stack of a solar cell is ablated using a laser. The dielectric film stack includes a layer that is absorptive in a wavelength of operation of the laser source. The laser source, which fires laser pulses at a pulse repetition rate, is configured to ablate the film stack to expose an underlying layer of material. The laser source may be configured to fire a burst of two laser pulses or a single temporally asymmetric laser pulse within a single pulse repetition to achieve complete ablation in a single step. | 2011-12-08 |
20110300666 | PHOTODIODE SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD - The invention provides a semiconductor device manufactured with a plurality of photodiodes so that it does not short circuit, and includes an opening without leakage. A second semiconductor layer ( | 2011-12-08 |
20110300667 | ELECTRIC-FIELD-SENSITIVE ELEMENT AND DISPLAY DEVICE USING THE SAME - An electric-field-sensitive element ( | 2011-12-08 |
20110300668 | USE OF DEVICE ASSEMBLY FOR A GENERALIZATION OF THREE-DIMENSIONAL METAL INTERCONNECT TECHNOLOGIES - An assembly process properly positions and align a plurality of first die within a carrier substrate. The first die are positioned within cavities formed in the carrier substrate. The carrier substrate is then aligned with a second substrate having a plurality of second die fabricated therein. The first die and the second die are fabricated using different technologies. Aligning the carrier substrate and the second substrate aligns the first die with the second die. One or more first die can be aligned with each second die. Once aligned, a wafer bonding process is performed to bond the first die to the second die. In some cases, the carrier substrate is removed, leaving behind the first die bonded to the second die of the second substrate. In other cases, the carrier substrate is left in place as a cap. The second substrate is then cut to form die stacks. | 2011-12-08 |
20110300669 | Method for Making Die Assemblies - The present invention relates to a method for making chip assemblies, including the following steps of: (a) providing a tested upper wafer and at least one tested lower wafer; (b) sawing the at least one tested lower wafer to form a plurality of lower dice, the lower dice including a plurality of know good lower dice; (c) picking up and rearranging the know good lower dice on a carrier according to the wafer map of the upper wafer; (d) bonding the upper wafer and the carrier; (e) removing the carrier; and (f) proceeding sawing step. Whereby, the dice of the die assembly are both known good dice, thus the yield loss caused by the different yields between the upper wafer and the lower wafer will not occur. | 2011-12-08 |
20110300670 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - The occurrence of a resin seal failure is suppressed. A molding step is carried out using a lead frame in which there are formed multiple air vent portions for discharging gas in each cavity formed in the upper die of a molding die to outside the cavity. The air vent portions are formed at positions overlapping with the other corner portions, arranged inside a gate portion of the cavity. Each of the air vent portions is led out from the other corner portions of the cavity to outside a clamp area and is extended along sides of the cavity, respectively, in the clamp area. | 2011-12-08 |
20110300671 | LEADFRAME-BASED SEMICONDUCTOR PACKAGE AND FABRICATION METHOD THEREOF - A leadframe-based semiconductor package and a fabrication method thereof are provided. The leadframe-based semiconductor package includes a chip implanted with a plurality of first and second conductive bumps thereon, and a leadframe having a plurality of leads. The first conductive bumps are bonded to the leads to electrically connect the chip to the leadframe. The chip, the first and second conductive bumps, and the leadframe are encapsulated by an encapsulant, with bottom ends of the second conductive bumps and bottom surfaces of the leads being exposed from the encapsulant. This allows the second conductive bumps to provide additional input/output electrical connections for the chip besides the leads. | 2011-12-08 |
20110300672 | SEMICONDUCTOR DEVICE, AND MANUFACTURING METHOD THEREFOR - To provide a semiconductor device with improved reliability. The semiconductor device includes a wiring board, a microcomputer chip flip-chip bonded over the wiring board via gold bumps, a first memory chip laminated over the microcomputer chip, wires for coupling the first memory chip to the wiring board, an underfill material with which a flip-chip coupling portion of the microcomputer chip is filled, and a sealing member for sealing the microcomputer chip and the first memory chip with resin. Further, the corner of a second opening portion of a solder resist film of the wiring board corresponding to the corner of the chip on the air vent side in charging the underfill material is made close to the microcomputer chip, which can improve the wettability and spread of the underfill material at the second opening portion, thus reducing the exposure of leads to the second opening portion, thereby improving the reliability of the semiconductor device. | 2011-12-08 |
20110300673 | POST-DISPENSE VACUUM OVEN FOR REDUCING UNDERFILL VOIDS DURING IC ASSEMBLY - An IC assembly method for reducing voids in underfill material. An IC die is bonded to a substrate which creates a gap between the IC die and the substrate. An underfill material that has a curing temperature (Tuc) is dispensed around at least one side along a perimeter of the gap, where capillary forces draw the underfill material into the gap to at least partially fill the gap to form an underfilled IC assembly. After the dispensing, a vacuum oven process is applied to the underfilled IC assembly which applies a vacuum of 15 to 140 torr and a temperature that is between Tuc −85° C. and Tuc −5° C., for reducing voids in the underfill material. The underfill material is then cured by heating the underfilled IC assembly to a temperature ≧ Tuc. | 2011-12-08 |
20110300674 | Method of crystallizing silicon layer and method of forming a thin film transistor using the same - A method of crystallizing a silicon layer and a method of manufacturing a thin film transistor using the same, the method of crystallizing the silicon layer including forming an amorphous silicon layer on a substrate; performing a hydrophobicity treatment on a surface of the amorphous silicon layer so as to obtain a hydrophobic surface thereon; forming a metallic catalyst on the amorphous silicon layer that has been subjected to the hydrophobicity treatment; and heat-treating the amorphous silicon layer including the metallic catalyst thereon to crystallize the amorphous silicon layer into a polycrystalline silicon layer. | 2011-12-08 |
20110300675 | Method of fabricating thin film transistor - The thin film transistor for an organic light emitting diode includes a crystalline semiconductor pattern on a substrate, a gate insulating layer on the crystalline semiconductor pattern having first source and drain contact holes, a gate electrode on the gate insulating layer, the gate electrode being between the first source and drain contact holes, an interlayer insulating layer covering the gate electrode, having second source and drain contact holes, source and drain electrode in the second source and drain contact holes, insulated from the gate electrode and electrically connected to the crystalline semiconductor pattern by first and second metal patterns in the first source and drain contact holes, respectively, wherein the gate electrode, the first metal pattern in the first source contact hole and the second metal pattern in the first drain contact hole are each made of a same material. | 2011-12-08 |
20110300676 | Method for Providing Lateral Thermal Processing of Thin Films on Low-Temperature Substrates - A method for thermally processing a minimally absorbing thin film in a selective manner is disclosed. Two closely spaced absorbing traces are patterned in thermal contact with the thin film. A pulsed radiant source is used to heat the two absorbing traces, and the thin film is thermally processed via conduction between the two absorbing traces. This method can be utilized to fabricate a thin film transistor (TFT) in which the thin film is a semiconductor and the absorbers are the source and the drain of the TFT. | 2011-12-08 |
20110300677 | Novel Method to Enhance Channel Stress in CMOS Processes - The invention provides a method of fabricating a semiconductor device that enhances the amount of stress that is transmitted to the channel region for carrier mobility enhancement. In one embodiment an amorphous region is formed at or near the gate dielectric interface prior to source/drain anneal. In a second embodiment the gate material is amorphous as deposited and processing temperatures are kept below the gate material crystallization temperature until stress enhancement processing has been completed. The amorphous gate material deforms during high temperature anneal and converts from an amorphous to a polycrystalline phase allowing more stress to be transmitted into the channel region. This enhances carrier mobility and improves transistor drive current. | 2011-12-08 |
20110300678 | Symmetric blocking transient voltage suppressor (TVS) using bipolar transistor base snatch - A symmetrical blocking transient voltage suppressing (TVS) circuit for suppressing a transient voltage includes an NPN transistor having a base electrically connected to a common source of two transistors whereby the base is tied to a terminal of a low potential in either a positive or a negative voltage transient. The two transistors are two substantially identical transistors for carrying out a substantially symmetrical bi-directional clamping a transient voltage. These two transistors further include a first and second MOSFET transistors having an electrically interconnected source. The first MOSFET transistor further includes a drain connected to a high potential terminal and a gate connected to the terminal of a low potential and the second MOSFET transistor further includes a drain connected to the terminal of a low potential terminal and a gate connected to the high potential terminal. | 2011-12-08 |