49th week of 2011 patent applcation highlights part 40 |
Patent application number | Title | Published |
20110300479 | TONER COMPOSITION WITH BROAD FUSING TEMPERATURE RANGE AND PROCESS FOR PREPARING THE SAME - The present invention relates to a toner composition with a broad fusing temperature range and a process for preparing the same. The toner composition according to the present invention creates entanglement between adjacent polymer chains using a non-linear polyester resin having a branch structure, provides elasticity to molten materials by the branch structure when the resin is molten, prevents the molten materials from being transferred to the surface of a roller at a high temperature, and thereby increases the maximum fusing temperature. Therefore, as the average branch number per polyester resin increases, the maximum fusing temperature rises and the fusing temperature range of the toner composition can be widened. | 2011-12-08 |
20110300480 | Toner Compositions - The present disclosure relates to a toner including a core comprising at least one amorphous resin, at least one crystalline resin and one or more optional ingredients such as optional colorants, optional waxes, gels, and combinations thereof. The toner also includes a shell having an environmentally friendly charge control agent co-emulsified with at least one amorphous shell resin. | 2011-12-08 |
20110300481 | PYRAZOLOTRIAZOLE COMPOUND AND ELECTROPHOTOGRAPHIC TONER - A compound represented by Formula (X-1) is disclosed. | 2011-12-08 |
20110300482 | SULFONIUM SALT, PHOTO-ACID GENERATOR, AND PHOTOSENSITIVE RESIN COMPOSITION - There is provided a sulfonium salt having high photosensitivity to the i-line. The invention relates to a sulfonium salt represented by formula (1) described below: [in formula (1), R | 2011-12-08 |
20110300483 | Self-Segregating Multilayer Imaging Stack With Built-In Antireflective Properties - A coating process comprises forming a patterned material layer on a substrate using a self-segregating polymeric composition comprising a polymeric photoresistive material and an antireflective coating material contained in a single solution. When depositing this solution on a substrate and removing the solvent, the two materials self-segregate into two layers. This produces a coated substrate having a uniaxial bilayer coating oriented in a direction orthogonal to the substrate with a top photoresistive coating layer and a bottom antireflective coating layer. Pattern-wise exposing the coated substrate to imaging radiation and contacting the coated substrate with a developer, produces the patterned material layer. Any optional top coat material and a portion of the photoresist layer can be simultaneously removed from the coated substrate to form a patterned photoresist layer on the substrate. | 2011-12-08 |
20110300484 | SULFONIUM DERIVATIVES AND THE USE THEROF AS LATENT ACIDS - Compounds of the formula (I), wherein Ar | 2011-12-08 |
20110300485 | ORGANIC SOLVENT DEVELOPMENT OR MULTIPLE DEVELOPMENT PATTERN-FORMING METHOD USING ELECTRON BEAMS OR EUV RAYS - Provided is a pattern-forming method including, in the following order: (1) a process of forming a film with an actinic ray-sensitive or radiation-sensitive resin composition comprising a resin which contains an acid-decomposable repeating unit and is capable of decreasing the solubility in an organic solvent by the action of an acid; (2) a process of exposing the film with an electron beam or an EUV ray; and (4) a process of developing the film with a developer containing an organic solvent. | 2011-12-08 |
20110300486 | DIRECTLY IMAGEABLE WATERLESS PLANOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD FOR PRODUCING SAME - A directly imageable waterless planographic printing plate precursor includes at least a heat sensitive layer and a silicone rubber layer formed on a substrate in this order and has a high sensitivity not only immediately after the precursor production but also after the passage of time. In the directly imageable waterless planographic printing plate precursor, the heat sensitive layer contains liquid bubbles filled with a liquid with a boiling point in the range of 210 to 270° C. A production method comprises applying a solution of a heat sensitive layer composition containing a solvent with a solubility parameter of 17.0 (MPa) | 2011-12-08 |
20110300487 | METHOD FOR PRODUCING A MATRIX OF INDIVIDUAL ELECTRONIC COMPONENTS AND MATRIX PRODUCED THEREBY - The invention relates to a method for producing a matrix of electronic components, comprising a step of producing an active layer on a substrate, and a step of individualizing the components by forming trenches in the active layer at least until the substrate emerges. The method comprises steps of depositing a layer of functional material on the active layer, depositing a photosensitive resin on the layer of material in such a way as to fill said trenches and to form a thin film on the upper face of the components, at least partially exposing the resin to radiation while underexposing the portion of resin in the trenches, developing the resin in such a way as to remove the properly exposed portion thereof, removing the functional material layer portion that shows through after the development step, and removing the remaining portion of resin. | 2011-12-08 |
20110300488 | Antireflective Coating Composition and Process Thereof - The invention related to an antireflective coating comprising a mixture of a first polymer and a second polymer, and a thermal acid generator, where the first polymer comprises at least one fluoroalcohol moiety, at least one aliphatic hydroxyl moiety, and at least one acid moiety other than fluoroalcohol with a pKa in the range of about 8 to about 11; where the second polymer is a reaction product of an aminoplast compound with a compound comprising at least one hydroxyl and/or at least one acid group. The invention further relates to a process for using the novel composition to form an image. | 2011-12-08 |
20110300489 | Method For Providing A Conductive Material Structure On A Carrier - An exemplary method for providing a conductive material structure on a carrier generally includes applying a photo sensitive material on the carrier and applying a mask on the photo sensitive material. The mask defines a conductive material structure to be formed on the carrier. The method also includes irradiating the defined structure on the carrier in order to prepare for metallization, and metalizing the defined structure for forming the conductive material structure. | 2011-12-08 |
20110300490 | HIGH-RESOLUTION MICROSCOPY AND PHOTOLITHOGRAPHY DEVICES USING FOCUSING MICROMIRRORS - The invention relates to large-field high-resolution microscopy and photolithography setups operating with polychromatic light. It includes the use of a plurality of focusing micromirrors. | 2011-12-08 |
20110300491 | UTILIZING A DILUENT TO LOWER COMBUSTION INSTABILITIES IN A GAS TURBINE ENGINE - A method of influencing combustion dynamics, including measuring a combustion dynamics parameter, and controlling a diluent flow ( | 2011-12-08 |
20110300492 | Method and Apparatus for Monitoring Combustion Properties in an Interior of a Boiler - A method of monitoring combustion properties in an interior of a boiler of the type having walls comprising a plurality of parallel steam tubes separated by a metal membrane. First and second penetrations are provided in the metal membrane between adjacent tubes on opposite sides of the boiler. A beam of light is projected through a pitch optic comprising a pitch collimating lens and a pitch relay lens, both residing outside the boiler interior. The pitch relay lens projects the beam through a penetration into the boiler interior. The beam of light is received with a catch optic substantially identical to the pitch optic residing outside the boiler interior. The strength of the collimated received beam of light is determined. At least one of the pitch collimating lens and the catch collimating lens may then be aligned to maximize the strength of the collimated received beam. | 2011-12-08 |
20110300493 | Methods and Systems For Controlling The Products of Combustion - The present invention relates to methods and systems for controlling a combustion reaction and the products thereof. One embodiment includes a combustion control system having an oxygenation stream substantially comprising oxygen and CO | 2011-12-08 |
20110300494 | CONTROL SYSTEM AND METHOD FOR A SOLID FUEL COMBUSTION APPLIANCE - A control system for a solid fuel combustion appliance, e.g., a wood burning stove, includes a temperature sensor for sensing an output temperature of the appliance. A controller receives the output temperature and controls a damper associated with air flow through the stove to maintain a predetermined temperature. The system also includes a detector that senses certain conditions of the solid fuel, e.g., wood, that is burned by the stove. When additional fuel is added to the appliance, the system temporarily encourages initial combustion of the new fuel, before returning to maintaining the predetermined temperature. | 2011-12-08 |
20110300495 | LIGHTER WITH GOLF SCREEN REPAIR TOOL AND GOLF BALL MARKER - This invention presents a cigarette lighter. The cigarette lighter has a lighter body and a golf green repair tool mounted on the lighter body. The golf green repair tool can slide between an extended position and a retracted position. The cigarette lighter also has a golf ball marker seat. A golf ball marker can be removeably mounted in the golfball marker seat. | 2011-12-08 |
20110300496 | Candle With Wax Beads And Solid Wax Topping - A candle includes a vessel of some volume containing some smaller volume of at least one variety of wax beads, having a diameter of less than or equal to 2.35 millimeters and in most embodiments also including a particular fragrance and color pigment. The was beads topped with a solid wax topping. The solid wax topping may cover the entire exposed surface of the candle, holding the wax beads in place during shipping and use and holding the wick in a centralized location. | 2011-12-08 |
20110300497 | OVEN FOR THE THERMAL CONDITIONING OF PREFORMS AND CONTROL METHOD OF AN AIR COOLING DEVICE FITTED TO SUCH AN OVEN | 2011-12-08 |
20110300498 | METHODS FOR OPERATING A FURNACE - A method for operating a furnace, such as, for example, a fluidized bed reactor, includes introducing an alkali-containing material and a hydrous clay into the furnace, the hydrous clay having a moisture content of at least about 5% by weight. The method further includes heating at least a portion of the alkali-containing material and hydrous clay, such that at least a portion of the hydrous clay is at least partially calcined and the at least partially calcined clay adsorbs at least a portion of alkali present in the furnace. The method further includes removing at least a portion of the at least partially calcined clay and adsorbed alkali from the furnace. | 2011-12-08 |
20110300499 | MULTIPLE TEMPERATURE POINT CONTROL HEATER SYSTEM - A multi-zone portable heater is provided having an oscillating heater and a plurality of remote sensors. The plurality of remote sensors are radially positionable about the oscillating heater in a spaced apart configuration, each defining a heating region. The remote sensors read a region temperature in their corresponding heating region and can transmits the corresponding region temperature to the heater signal transmitter/receiver. Alternatively, the oscillating heater can transmit a set temperature to each of the plurality of remote sensors, where the remote sensors calculates a region temperature difference between the read region temperature and the set temperature. The region temperature difference being transmitted to the oscillating heater. In this manner, the operational parameters of the oscillating heater can be selectively controlled for each of the regions. | 2011-12-08 |
20110300500 | Adjustable orthodontic bracket positioning device and method thereof - An adjustable orthodontic bracket-positioning device includes an adjustable bracket-positioning jip, a positioning vernier and a dental crown vernier. First, using the crown vernier to measure the crown height value of patients' tooth, and labeling the measured center height value of clinical dental crown on the positioning vernier, correctly position the adjustable bracket-positioning jip in the groove shape base of the positioning vernier, and finally use the adjustable bracket-positioning jip to bond MBT bracket. | 2011-12-08 |
20110300501 | LIGATING DEVICE FOR ARCH WIRES OR ORTHODONTIC WIRES AND RESPECTIVE METHOD FOR THE APPLICATION OF AN ARCH WIRE OR AN ORTHODONTIC WIRE - The present invention relates to a ligating device ( | 2011-12-08 |
20110300502 | SELF-ADJUSTABLE, SELF-LIGATING ORTHODONTIC BRACKET - A self-adjustable, self-ligating orthodontic bracket is disclosed. The bracket comprises a base with a tooth face bonded to a surface of a tooth. A linking body comprises a body connection. The linking body is in physical communication with an archwire transmitting a force to the linking body. A connector applies a tension between the linking body and the base motivating the linking body and the base toward a normal position. | 2011-12-08 |
20110300503 | Device for Fixing Orthodontic Devices - A fixing device ( | 2011-12-08 |
20110300504 | METHOD AND LASER PROCESSING DEVICE FOR PROCESSING TISSUE - Method and laser processing device to process tissue. In a general aspect, the method to process tissue may include applying a photosensitizer into an area surrounding a region of the tissue to be processed, and irradiating the region of the tissue to be processed with the pulsed processing laser beam, the laser beam emitting laser pulses with a temporal full width at half maximum in a range between about 100 femtosecond and about 1 nanosecond. In another general aspect, the laser processing device to process tissue may include a laser radiation source to provide a pulsed processing laser beam providing emitting laser pulses, a laser beam decoupling unit to decouple the laser beam towards a region of the tissue to be processed, and an output device to output a photosensitizer in a direction of an area surrounding the region of the tissue to be processed, the output device being connected to the decoupling unit. | 2011-12-08 |
20110300505 | Dental Curing Light Having Unibody Design That Acts as a Heat Sink - A dental curing light includes a device body that efficiently conducts heat away from the light emitting diode portion of the curing light. The device body includes a proximal gripping end and a distal head end. The device body is formed from a thermally conductive body material. Excellent heat conduction away from the LED dies is achieved using a thermally conductive layer disposed over the device body. The thermally conductive layer serves as a conduit to quickly conduct heat away from the LED dies for dissipation within the material of the device body In this manner, the material of the device body serves as a highly efficient heat dissipater. The surface area coupling the thermally conductive layer to the device body is sufficiently large that a majority (e g, substantially all) of heat being conducted by the thermally conductive layer is transferred to the device body during operation of the device. | 2011-12-08 |
20110300506 | Endodontic File With Working Length Adjustment Scale - An endodontic file is provided for use during root canal therapy. The endodontic file has a handle, a blade, and a marker. The marker provides a working length adjustment scale that is integrated with the handle and the blade. After adjustment of the endodontic file to a desired working length, compared to the depth of a subject root canal, the marker is maintained in a substantially static position relative to the blade, which is itself stationary relative to the handle. The endodontic file reduces the chances of unintended complications during root canal therapy, for example if the blade were to penetrate into various tissues located in proximity to the root canal. | 2011-12-08 |
20110300507 | ELASTICALLY FLEXIBLE COUPLING BODY - The invention relates to a coupling body that can convert a linear input movement into a linear output movement transversal to the input movement. The coupling body includes two parallel flexional arms of the same length, the ends of the flexional arms being connected by means of transversal connection arms. The connection arms carry driving bodies which represent load bodies arranged at the same distance from the neutral lines of the connection arms, in the same direction. | 2011-12-08 |
20110300508 | PROCESS FOR PRODUCING RESIN COMPOSITION AND PROCESS FOR PRODUCING MOLDED ARTICLE - A medical resin composition is produced by mixing a powder of a polymer (A) comprising repeating units having an ester group and a liquid of a vinyl ester monomer (B) having 6 or more carbon atoms to increase a viscosity and, according to demand, further performing a polymerization reaction. The thus produced resin composition inhibits leaching of irritative substances, reduces any adverse effects on the human body by endocrine disruptors, etc. and can be prepared with high operational efficiency. The resin composition is suitably used as a dental resin composition such as a tissue conditioner, a functional impression material, a lining material, a denture base material or a mouth piece material. | 2011-12-08 |
20110300509 | METHOD AND KIT FOR PREPARING A DENTAL ABUTMENT - A method and kit and components thereof for forming an abutment for interfacing a dental prosthesis to a dental implant or duplicate inserted into a patient's jaw or model thereof. An intra-implant element that is or may be bonded to an intra-crown element via a resilient bonding material to form a deformable connection is inserted into the dental implant or duplicate. The intra-crown element is adjusted relative to the intra-implant element to form a model abutment that is properly adjusted to the dental implant or duplicate and is properly positioned to receive a dental prosthesis. The connection is strengthened so that removal of the model abutment and attached dental prosthesis from the dental implant or duplicate does not deform the model abutment, the model abutment and attached dental prosthesis are removed from the dental implant or said duplicate; and the model abutment used to form a permanent abutment. | 2011-12-08 |
20110300510 | DENTAL IMPLANT - The present invention discloses a dental implant which allows an immediate masticatory function just after being implanted in a bone structure, does not need a secondary operation, and can be effectively applied even in thin and short alveolar bone. The dental implant comprises a body portion to be inserted in the bone structure and a mounting portion integrally formed on an upper portion of the body portion, the body portion including a thin and short core, screw blades formed along an outer peripheral surface of the core in the shape of a wide and deep screw, and a connecting portion formed in the shape of a plurality of holes and grooves vertically passing through the circumference thereof and capable of containing bone growth factors. An outer circumference of a proximal portion, an uppermost portion of the body portion, is smaller than a maximum diameter of the body portion and the mounting portion is smaller than the maximum diameter of the body portion, and the mounting portion has a gum adhering portion to protect bone tissues and a post to be mounted with an abutment or a prosthesis thereon. | 2011-12-08 |
20110300511 | FIBER-REINFORCED COMPOSITE POST - A fiber-reinforced composite post having an inner core section or rod fabricated of fibers impregnated in a resin matrix and an outer sheath of fibers arranged in the form of a mesh. The outer sheath comprises an interior and an exterior surface, the exterior surface is dry and unembedded fibers, and the outer sheath is attached to the inner core. In an embodiment of the dental post, the interior surface of the mesh is embedded in the resin matrix of the inner core with the inner core fibers. | 2011-12-08 |
20110300512 | APEX LOCATOR MOUNTABLE ON A HANDPIECE - An apex locator for measuring a root canal apex, comprising: | 2011-12-08 |
20110300513 | APPARATUS AND METHOD FOR ROOT CANAL OBTURATION - The present invention is directed to root canal obturation in a tooth. In one embodiment, a plug is positioned in a root canal and bonded to the root canal by applying a light-curing adhesive to the canal and exposing the plug to a light source to bond the plug to the root canal. In another embodiment, a carrier is disclosed having an optically transmissive plug portion for insertion into the canal. In still another embodiment, the plug portion of the carrier includes an optical fiber to transmit light from a light source into the plug portion. In still yet another embodiment, a filler material is heated and injected into the root canal in a semi-liquid state and exposed to light to cure the adhesive. | 2011-12-08 |
20110300514 | METHOD OF TACTICAL TRAINING USING A PORTABLE STRUCTURE AND A PORTABLE STRUCTURE - Disclosed is a portable training structure and a method for tactical training using a portable structure. | 2011-12-08 |
20110300515 | SYSTEM AND METHOD TO MINIMIZE LASER MISALIGNMENT ERROR IN A FIREARMS TRAINING SIMULATOR - A weapon simulation system is used to correct the misalignment between a laser of a simulated weapon and an aim point of the simulated weapon. A compensation offset profile and a compensation angle profile are stored in a weapon controller card in the simulated weapon identifying the misalignment of the laser module in the corresponding simulated weapon. The compensation offset profile and compensation angle profile is transmitted from the weapon controller card to a central computer, where the central computer calculates the aim point of the simulated weapon using said compensation offset profile and said compensation angle profile from said weapon controller card. The position of the simulated weapon with respect to a screen of the weapon simulation system is further calculated using an RFID reader in electrical communication with the weapon controller card and at least one RFID tag positioned in a fire line mat, which transmits the position information to said central computer. | 2011-12-08 |
20110300516 | Tactile Tile Vocalization - Braille symbols are automatically read aloud, to aid in learning or using Braille. More generally, a tile which bears a tactile symbol and a corresponding visual symbol is placed in a sensing area, automatically distinguished from other tiles, and vocalized. The tile is sensed and distinguished from other tiles based on various signal mechanisms, or by computer vision analysis of the tile's visual symbol. Metadata is associated with the tile. Additional placed tiles are similarly sensed, identified, and vocalized. When multiple tiles are placed in the sensing area, they are vocalized individually, and an audible phrase spelled by their arrangement of tactile symbols is also produced. A lattice is provided with locations for receiving tiles. Metadata are associated with lattice locations. Tile placement is used to control an application program which responds to tile identifications. | 2011-12-08 |
20110300517 | DRUG-FREE METHOD AND SYSTEM FOR REDUCTION OF LACTIC ACID WHILE TRAINING ATHLETES USING PH BALANCING - A drug-free method for training athlete(s) using ph balancing including the steps of eating from a trainer-specified meal plan; training according to a trainer-specified training plan; and pH testing of the athlete(s). The athlete's diet is maintained according to the trainer-specified meal plan, followed by the athlete training in accordance to the trainer-specified training plan. The athlete then undergoes pH testing to determine if they have a proper body pH balance to maximize training results. Further, a kit is disclosed having a set of charts, a saliva ph tester; a urine ph tester; pre-train and post-train supplement drinks; a set of vitamin supplements; and user instructions. | 2011-12-08 |
20110300518 | Nutritional game and method for teaching nutrition to children - A nutritional game and related method for educating children regarding proper nutrition is disclosed. The nutritional game includes a board having a character illustrated on the surface of the board which is divided into a plurality of sectors. Nutritional cards are provided in which each nutritional card is configured to cover a respective sector with each nutritional card representing a particular nutrient group, which includes a list of foods representative of that nutrient group. In addition, the nutritional game is played by having the child remove one or more nutritional cards that cover the different sectors of the board as the child eats the foods listed on each nutritional card for a particular nutrient group until all of the nutritional cards are removed from the board, thereby rewarding the child at character illustrated on the board is revealed to the child. | 2011-12-08 |
20110300519 | EDUCATIONAL METHOD FOR IMPROVING DIETARY HABITS - The invention provides an educational method for increasing a subject's skill in human nutrition science from a first low skill level to a second high skill level. The method comprises enrolling the subject in one education pathway with one or more skill levels therein. Each skill level has one or more educational goals associated with it, the knowledge levels increase as the subject progresses along the education pathway. Another education pathway is provided and operates simultaneously and progressively with the first education pathway. The other education pathway has associated with it at least one nutrition educating session, which is adapted to achieve at least one of the educational goals. The successful completion of the educational goal allows the subject to move to the next skill level in the first education pathway, thereby increasing the subject's knowledge and skill in human nutrition science. | 2011-12-08 |
20110300520 | SYSTEMS AND METHODS FOR ASSISTING A USER IN ORGANIZING AND WRITING A RESEARCH PAPER - A system for assisting a user in organizing and writing a research paper. The system includes a thesis module configured to run on a processor and to present a series of questions to the user, receive input regarding the series of questions, and to assemble a thesis statement based on the input received; a research module configured to run on the processor and to output topics related to the thesis statement, to output research notes, and to assemble source citations; an organization module configured to run on the processor and to edit the topics and research notes and to arrange the topics and the research notes within the topics in a predetermined order; and a writing module configured to run on the processor and to create an editable draft of the research paper that includes the thesis statement and the content of the research notes arranged in the predetermined order. | 2011-12-08 |
20110300521 | PYTHAGOREAN DIDACTIC SET - The present invention refers to a new didactic Pythagorean set, being in the field of didactic material, which enables the students of college and university levels, to work in an implicit way the Pythagoras theorem; this is possible since this didactic material sets out in an arithmetic, geometric and algebraic way such famous result. Also, it enables the students of high school and college levels to be introduced to the trigonometric functions subject. Besides the present invention provides the user with a didactic tool whereby he could design and implement additional activities with the students, and incorporate such activities in any of the levels of study, as appropriate. | 2011-12-08 |
20110300522 | METHOD AND DEVICE FOR ASSESSING, TRAINING AND IMPROVING PERCEPTUAL-COGNITIVE ABILITIES OF INDIVIDUALS - A device and method for evaluating or improving perceptual-cognitive abilities of a subject, comprising displaying virtual objects moving in a given three-dimensional environment during successive tests. The subject is in visual contact with the virtual objects moving in the three-dimensional environment, and the speed of movement of the virtual objects in the three-dimensional environment during the successive tests is changed. | 2011-12-08 |
20110300523 | Team Electronic Gameplay Combining Different Means of Control - Disclosed are methods and apparatuses provided for modifying the effect of an operator controlled input device on an interactive device to encourage the self-regulation of at least one physiological activity by a person different than the operator. The interactive device comprises a display area which depicts images and apparatus for receiving at least one input from the operator controlled input device to thus peiiiiit the operator to control and interact with at least some of the depicted images. One effect modification comprises measurement of the physiological activity of a person different from the operator, while modifying the ability of the operator to control and interact with at least some of the depicted images by modifying the input from the operator controlled input device in response to changes in the measured physiological signal. | 2011-12-08 |
20110300524 | ROSARY PRAYER STAND - A rosary prayer stand may include frame, a plurality of parallel rods mounted on the frame, and a plurality of beads for counting prayers. Each bead's position on the stand and/or color may correspond to a particular rosary prayer. When each prayer is recited, the bead corresponding to that prayer is slid across the rod. The plurality of rods may have axes that intersect a transverse reference plane at locations along an arched path. | 2011-12-08 |
20110300525 | Workload Management System - A system and method designed to enable schools to proactively manage and analyze a student's workload. The workload management system helps identify, for each individual student, workload hotspots early and helps teachers and administrators in schools take action to mitigate the stress that such workload hotspots create. | 2011-12-08 |
20110300526 | Systems And Methods For Facilitating Classroom Interaction - In one embodiment, facilitating classroom interaction includes sending a message containing a question to be answered from a mobile device located within a classroom at which a class is being taught, receiving the message with a central server and identifying the class to which the message pertains, and displaying the question on a display device located within the classroom. | 2011-12-08 |
20110300527 | TEACHING METHOD - Aspects of the present invention include one or more of capturing educational presentations by presenters using instructional aids, making presentations available via the World Wide Web to users of educational services, aiding users in the selection of a particular topic and a particular presenter, rewarding students for achievement, and financially compensating presenters in accordance with the popularity of their educational presentations. | 2011-12-08 |
20110300528 | Methods for Bacteriophage Design - Methods for designing and breeding phages are described. The methods include methods to design phages for previously resistant bacterial strains. The methods described do not use genetic manipulation techniques. | 2011-12-08 |
20110300529 | DETECTION OF IFI16 IN BODY FLUIDS - The present invention relates to methods for the qualitative and/or quantitative determination of interferon inducible protein 16 (IFI 16) in an extracellular form. | 2011-12-08 |
20110300530 | IN VITRO TEST SYSTEM FOR VIRAL INFECTIONS - The invention relates to a multi-layered biological in vitro tissue containing: dermis layer, containing a collagen biomatrix with fibroblasts embedded therein and epidermis layer, containing epithelial cells. It is provided that latently virally infected neuronal cells are integrated at least into the dermis layer. | 2011-12-08 |
20110300531 | METHOD AND DEVICE TO DETECT THE PRESENCE OF ANALYTES IN A SAMPLE - Disclosed are methods and apparatus useful for determining the presence or absence of one or more analytes in a liquid sample, such as a biological or environmental sample. In some embodiments, the method can use an indirect competitive immunochromatographic test strip. | 2011-12-08 |
20110300532 | CONTROL OF THE TOXICITY OF GOLD NANOPARTICLES - The present invention relates to gold nanocluster compounds, especially gold nanoparticles, having a reduced toxicity, especially cytotoxicity, which are preferably appropriate for use in medical diagnostics such as medical imaging (e.g. X-ray, CT etc.), said gold nanocluster compounds comprising a core of at least one gold atom and at least one ligand bound to said core, wherein the reduction of toxicity, especially cytotoxicity, of said gold nanocluster compound is controlled and/or adjusted via its ligand structure and/or its ligand chemistry. | 2011-12-08 |
20110300533 | Yeast Screens for Treatment of Human Disease - Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes. | 2011-12-08 |
20110300534 | COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS - Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration of a signal associated with nucleotide incorporation, resulting in more observable sequencing events and increasing the accuracy of nucleic acid sequencing. | 2011-12-08 |
20110300535 | METHOD OF IDENTIFYING INDIVIDUALS AT RISK OF THIOPURINE DRUG RESISTANCE AND INTOLERANCE - The invention relates to methods and kits for identifying individuals at risk of thiopurine drug intolerance based on detecting the presence of mutations in the TPMT gene promoter associated with thiopurine drug resistance or intolerance. | 2011-12-08 |
20110300536 | GENE MARKER AND METHOD FOR DETECTION OF ORAL CANCER - A gene marker for the detection of oral cancer, comprising methylated CpG sites in target genes, is provided. The CpG sites in the target genes are selected from a group consisting of the following CpG sites: FLT4_E206_F, ASCL1_E24_F, KDR_E79_F, TFPI2_P9_F, TERT_E20_F, ADCYAP1_P455_R, MT1A_P49_R, and combinations thereof. A method for the detection of oral cancer, comprising the following steps is also provided: a) providing a sample to be examined from an individual; b) detecting a methylation state of at least one CpG site in a target gene on the genomic DNA from cells of the sample, wherein the CpG site in the target gene is selected from a group consisting of the following CpG sites: FLT4_E206_F, ASCL1_E24_F, KDR_E79_F, TFPI2_P9_F, TERT_E20_F, ADCYAP1_P | 2011-12-08 |
20110300537 | METHODS OF DETECTING SEQUENCE DIFFERENCES - The invention relates to methods of genotyping single nucleotide differences in a nucleic acid sample. More particularly, the invention provides methods of identifying the nucleotide at a polymorphic site or a group of polymorphic sites in a sample of genomic DNA. The method uses tagged primer extension in which a set of tag sequences correspond to the identity of the nucleotides at the polymorphic sites. Primer extension products are PCR amplified using a common set of tag-specific primers, the downstream primers bearing distinguishable labels. Following separation by size and/or charge, the detection of distinguishable label in a product of the anticipated size determines the identity of the nucleotide at the polymorphic site. The method is well-suited for the genotyping of multiple single-nucleotide differences in one series of reactions. | 2011-12-08 |
20110300538 | BIFIDOBACTERIA CRISPR SEQUENCES - The invention relates to CRISPR sequences found in bifidobacteria and their uses. | 2011-12-08 |
20110300539 | Method for Detecting Polymorphism at Nucleotide Position -1639 of VKORC1 Gene, and Nucleic Acid Probe and Kit Therefor - A probe for detecting a polymorphism at position −1639 of the VKORC1 gene, the probe comprising an oligonucleotide having a nucleotide sequence having a length of 10 to 50 nucleotides, which nucleotide sequence comprises the nucleotides 80 to 89 of SEQ ID NO:1 or 2 and has a homology to SEQ ID NO:1 or 2 except that the nucleotide corresponding to the nucleotide at position 80 in SEQ ID NO:1 or 2 is cytosine, which nucleotide corresponding to the nucleotide at position 80 is labeled with a fluorescent dye. | 2011-12-08 |
20110300540 | METHODS AND PROBE COMBINATIONS FOR DETECTING MELANOMA - The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells. | 2011-12-08 |
20110300541 | Detection and typing of bacterial strains - Methods for the detection and typing of bacterial strains from food products and dietary supplements, environmental samples, in vivo/in vitro samples, and for studying the natural diversity of the species are disclosed. Potential applications also include product development and/or detection and differentiation of new bacterial strains. | 2011-12-08 |
20110300542 | Gene Expression Profiling For Identification, Monitoring And Treatment Of Multiple Sclerosis - The present invention provides methods of characterizing multiple sclerosis pr inflammatory conditions associated with multiple sclerosis using gene expression profiling. | 2011-12-08 |
20110300543 | METHODS FOR MAKING INDUCED PLURIPOTENT STEM CELLS FROM MESENCHYMAL STEM CELLS - The invention is directed to methods for making iPS cells from Mesenchymal Stem Cells (MSCs). In certain aspects the methods comprise expression of Oct4 in MSCs, thereby converting the MSCs to iPS cells. | 2011-12-08 |
20110300544 | ENHANCED TAQMAN PROBE BASED AMPLIFICATION - The present invention relates to the field of amplification and detection. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on target amplification using a polymerase with 5′ nuclease activity. The invention also provides probes and kits for use in such method. | 2011-12-08 |
20110300545 | Primers for the rapid and specific detection of propane-oxidizing and butane-oxidizing microorganisms and methods of using same - Nucleic acid sequences are provided which in an embodiment provide a primer pair. The primers are capable of amplifying a nucleic acid molecule that indicates the presence of a propane-oxidizing and/or butane-oxidizing microorganism. A method is provided which employs such primers in a process that indicates the presence of such organisms. The method is useful in detecting the presence of petroleum-like products. | 2011-12-08 |
20110300546 | METHOD OF UTILIZING THE PTS GENE AND RNA INTERFERENCE OF THE ADS GENE TO INCREASE PATCHOULI ALCOHOL CONTENT IN ARTEMISIA ANNUA L. - The invention relates to a method of utilizing the pts gene and RNA interference of the ads gene to increase patchouli alcohol content in | 2011-12-08 |
20110300547 | METHOD OF UTILIZING THE PTS GENE AND ANTI-SENSE ADS TO INCREASE PATCHOULI ALCOHOL CONTENT IN ARTEMISIA ANNUA L. - The invention relates to a method of utilizing the pts gene and antisense ads to increase patchouli alcohol content in | 2011-12-08 |
20110300548 | GDF15 AS MOLECULAR TOOL TO MONITOR AND ENHANCE PHENOTYPIC STABILITY OF ARTICULAR CHONDROCYTES - The present invention relates to GDF15 as a molecular marker in in vitro assays determining phenotypic stability of articular chondrocytes and predicting the outcome of chondrocyte transplantation. | 2011-12-08 |
20110300549 | Treatment of Development-Related Disorders - Disclosed are composition and methods for treating development-related disorders. Also disclosed are diagnosis methods, prognosis methods, and drug screening methods. | 2011-12-08 |
20110300550 | METHOD FOR DETECTING NUCLEIC ACID IN BIOLOGICAL SAMPLE - The present invention is to provide a method capable of efficiently and readily detecting a nucleic acid from a biological sample such as feces. | 2011-12-08 |
20110300551 | METHOD OF PREDICTING CLINICAL OUTCOMES FOR MELANOMA PATIENTS USING CIRCULATING MELANOMA CELLS IN BLOOD - The present invention provides an automated method for capturing and detecting circulating melanoma cells (CMC's) in the blood of patients with melanoma. The absolute number of circulating melanoma cells detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. | 2011-12-08 |
20110300552 | Systems and Methods for Determining Drug Resistance in Microorganisms - The present invention is based on the discovery that drug resistance in microorganisms can be rapidly and accurately determined using mass spectrometry. A mass spectrum of an intact microorganism or one or more isolated biomarkers from the microorganism grown in drug containing, isotopically-labeled media is compared with a mass spectrum of the intact microorganism or one or more isolated biomarkers from the microorganism grown in non-labeled media without the drug present. Drug resistance is determined by predicting and detecting a characteristic mass shift of one or more biomarkers using algorithms. The characteristic mass shift is indicative that the microorganism is growing in the presence of the drug and incorporating the isotopic label into the one or more biomarkers, resulting in change in mass. | 2011-12-08 |
20110300553 | ENGINEERING COMPLEX MICROBIAL PHENOTYPES WITH SUCCESSIVE INTEGRATIONS OF EXOGENOUS DNA (SIEDNA) - The present invention relates to a recombinant | 2011-12-08 |
20110300554 | EXPONENTIAL ISOTHERMAL SELF-SUSTAINED REPLICATION OF AN RNA ENZYME - This invention provides nucleic acid molecules that catalyze their own replication and undergo exponential amplification at a constant temperature and in the absence of proteins or other biological components, such as those employed in other amplification reactions, e.g., proteins including DNA or RNA polymerase and a method of detect a selected molecule using said nucleic acid. | 2011-12-08 |
20110300555 | ASSAY DEVICE COMPRISING BUBBLE-FORMING MEANS - Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of: contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent upon the presence, absence or amount of analyte, which gas creates one or more bubbles in the liquid sample which act to alter the flow of liquid along a flow path; and determining an alteration of flow in the liquid wherein the alteration of flow of liquid along the flow path is indicative of the presence and/or amount of analyte in the liquid sample. | 2011-12-08 |
20110300556 | MONOCLONAL ANTIBODIES DETECTION METHODS FOR ENZYMES THAT CONFER RESISTANCE TO 2,4-DICHLOROPHENOXYACETIC ACID IN PLANTS - Described herein are monoclonal antibodies and methods useful for determining and quantitating the presence of an aryloxyalkanoate dioxygenase enzyme. | 2011-12-08 |
20110300557 | METHODS FOR PREDICTING PREGNANCY OUTCOME IN A SUBJECT BY hCG ASSAY - The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample. | 2011-12-08 |
20110300558 | NANOPARTICLE FOR BIOAFFINITY ASSAYS - Thus this invention relates to a nanoparticle, useful for bioaffinity assays. The nanoparticle has a self-assembling shell built up of several protein and/or peptide subunits, which protein and/or peptide subunits can be of one or several different types, assembled in an organized manner to form the shell having an inner surface facing the inside and an outer surface facing the outside of said particle. One or several of the types of subunits have one or several first binding moieties per type of subunit with the binding moiety facing the outside of the particle for binding of any specific ligand binding protein; and the particle contains within its shell a marker and/or one or several of the types of subunits have one or several second binding moieties per type of subunit with the binding moiety facing the inside and/or the outside of the particle for binding a marker; and the marker or markers enables detection of the particle. Characteristic for the nanoparticle is that the shell of the nanoparticle is a recombinant apoferritin or an apoferritin-like particle. This invention also relates to a bioaffinity assays using the nanoparticle. This invention further relates to a kit for bioaffinity assays comprising the nanoparticle. | 2011-12-08 |
20110300559 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER AND NEURODEGENERATIVE DISEASES RELATED TO BECLIN-1 - The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases. | 2011-12-08 |
20110300560 | NOVEL MEMBERS OF THE CAPSAICIN/VANILLOID RECEPTOR FAMILY OF PROTEINS AND USES THEREOF - The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR-1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. | 2011-12-08 |
20110300561 | Method for Identifying Inhibitors of Staphylococcus Aureus - Provided are methods for identifying and/or designing inhibitors of | 2011-12-08 |
20110300562 | GDF15 AS A DIFFERENTIAL MARKER FOR SPONDYLOARTHROPATHY - In vitro methods for differential diagnosis of spondyloarthropathy are disclosed which involve determining the levels of GDF15 in biological samples. | 2011-12-08 |
20110300563 | METHODS OF PREPARING AND OPERATING PORTABLE, POINT-OF-CARE, USER-INITIATED FLUIDIC ASSAY SYSTEMS - Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may include one or more fluid chambers, one or more fluid paths amongst the fluid chambers and/or between the fluid chambers, a sample portion, and/or an assay portion. The assay system may include a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The user-initiated actuator system may include an external user-operated trigger mechanism. The assay apparatus may include a display window to view assay results. | 2011-12-08 |
20110300564 | DIAGNOSIS OF PRE-ECLAMPSIA - The present invention relates to a method of predicting pre-eclampsia (PE). The present invention also relates to a diagnostic kit for performing a method of predicting PE. In particular, the method determining the level of two or more markers selected from placenta growth factor (PlGF), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2 (PAI-2) and leptin. | 2011-12-08 |
20110300565 | ANALYSIS METHOD, ANALYSIS DEVICE, PROGRAM USED TO IMPLEMENT SAID ANALYSIS METHOD, AND STORAGE MEDIUM AND RETRIEVAL DEVICE FOR THIS PROGRAM - An analysis apparatus includes a first analysis unit which collects samples by utilizing a first nozzle to analyze the sample, a second analysis unit which collects samples by utilizing a second nozzle to analyze the sample, and a transport apparatus which transports a plurality of sample vessels along a predetermined transport route. When a predetermined waiting state is provided such that the transport of the plurality of sample vessels is interrupted or stopped, then the sample collecting position is changed for at least one of the first and second nozzles, and the samples are collected from the plurality of sample vessels by means of the nozzle having the changed position. Accordingly, it is possible to enhance the efficiency of the analysis process performed by the analysis apparatus, while suppressing the transport apparatus from being large-sized and suppressing the structure from being complicated. | 2011-12-08 |
20110300566 | METHODS FOR SCREENING FOR HISTONE DEACETYLASE ACTIVITY AND FOR IDENTIFYING HISTONE DEACETYLASE INHIBITORS - The present invention relates to novel methods for screening for histone deacetylase enzyme activity in a test sample. The present invention further relates to novel methods for screening potential inhibitors of histone deacetylase enzymes. | 2011-12-08 |
20110300567 | METHOD FOR DETERMINING REDOX ACTIVITY AND SCREENING COMPOUNDS BASED ON REDOX ACTIVITY - A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications. | 2011-12-08 |
20110300568 | SYSTEMS AND METHODS FOR PROCESSING ALGAE CULTIVATION FLUID - Systems and methods for reducing an amount of unwanted living organisms within an algae cultivation fluid are provided herein. According to some embodiments, methods may include subjecting the algae cultivation fluid to an amount of cavitation, the amount of cavitation being defined by a pressure differential between a downstream pressure and a vapor pressure, the pressure differential divided by half of a product of a fluid density multiplied by a square of a velocity of an apparatus throat. | 2011-12-08 |
20110300569 | DATA ANALYSIS OF IMPEDANCE-BASED CARDIOMYOCYTE-BEATING SIGNALS AS DETECTED ON REAL-TIME CELL ANALYSIS (RTCA) CARDIO INSTRUMENTS - A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements. | 2011-12-08 |
20110300570 | METHOD AND SYSTEM FOR GENERATING SPATIALLY AND TEMPORALLY CONTROLLABLE CONCENTRATION GRADIENTS - The ability to rapidly generate concentration gradients of diffusible molecules has important applications in many chemical and biological studies. The present invention is directed to methods and systems for generating spatially and temporally controllable concentration gradients of molecules (i.e. proteins or toxins) in a portable microfluidic device. The formation of the concentration gradients can be initiated by an induced forward flow and further optimized during an induced backward flow. The forward and backward flows can be either passively induced and/or actively pumped. The centimeter-length gradients along the microfluidic channel can be spatially and temporally controlled by the backward flow. The gradient profile was stabilized by stopping the flow. In one example, a stabilized concentration gradient of a cardiac toxin, Alpha-cypermethrin, generated according to the invention was used to test the response of HL-1 cardiac cells in the microfluidic device, which correlated with toxicity data obtained from multi-well plates. The invention can be useful for bio-logical and chemical processes that require rapid generation of concentration gradients in a portable microfluidic device. | 2011-12-08 |
20110300571 | Determination of the Liver Toxicity of an Agent - The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant. | 2011-12-08 |
20110300572 | IN VITRO METHOD AND APPARATUS FOR DETERMINING EFFICACY AND ACTION MECHANISMS OF A TOPICAL COMPOSITION ON VARIOUS SKIN COLOR TYPES - The present invention relates to in vitro methods for determining efficacy of topical compositions on various skin color types. These methods involve providing an artificial skin apparatus configured to approximate the color and diffuse reflectance characteristics of a predetermined human skin color type. The artificial skin apparatus includes an artificial skin substrate combined with a color background, with the color background correlating to the human skin color type. A topical composition of interest is applied to the artificial skin substrate of the artificial skin apparatus and then pre-irradiated. The pre-irradiated topical composition is then analyzed using relevant experimental techniques or assays for at least one efficacy parameter, including, for example, anti-ageing, photoprotective, sun protective, UVA/UVB protective, UVAI protective, photo stabilizing, and photosensitizing activities and action mechanisms of the topical composition on various skin color types. Also provided is an artificial skin apparatus and kit for use with the in vitro method. | 2011-12-08 |
20110300573 | METHOD TO CHARACTERIZE BLOOD AND RED BLOOD CELLS VIA ERYTHROCYTE MEMBRANE FRAGILITY QUANTIFICATION - A method for quantifying the quality degradation of individual stored red blood cell (RBC) units, thereby yielding information to improve decisions regarding their respective allocation, patient suitability, and use. The method comprises: a hemolysis step; an optical analysis step; and a computation step. The method is amenable to clinical implementation as well as indicative of any given unit's relative viability and thus prospective efficacy. This would provide clinicians with actual data on RBC quality when making decisions about which and how many units to use for transfusion of a given patient. Moreover, deploying this testing throughout the supply chain will improve distribution, planning, and inventory control decisions. A vital aspect of this testing method is the accumulation of copious output and other associated data and the mathematical analyses thereof to optimize algorithms by which to characterize each subsequent test output as meaningfully as possible. While the present invention is directed toward applications in blood quality control, the core technology of “quantifying RBC fragility via stress-induced hemolysis and subsequent optical and computational analysis” could have broader application, such as in disease diagnosis. | 2011-12-08 |
20110300574 | CELL-COUNTING METHOD FOR BLOOD HEMOLYSIS ANALYSIS IN FRAGILITY MEASUREMENT - A method of using cell counting to determine how much hemolysis occurs when a sample of red blood cells is subjected to stress, for purposes of either assessing stored blood quality and/or obtaining red blood cell fragility profiles. Cell-counting techniques and technologies can be employed to facilitate and enhance fragility measurements of red blood cells. There are many ways such “counting” can be achieved, including by visually counting each cell appearing under a microscope and projecting an estimated concentration based thereupon, or by utilizing a range of automatable technologies of various means. Using sophisticated image analysis algorithms, some such technologies also provide useful information about cell features or properties such as average size, distribution of sizes or volumes, and viability. Using cell counting to analyze post-stress hemolysis also permits conducting fragility assays without requiring centrifugation or other separation. | 2011-12-08 |
20110300575 | CELL-FREE SYSTEM FOR SYNTHESIS OF PROTEINS DERIVED FROM CULTURED MAMMALIAN CELLS - Prepared is an extract composition having an improved protein synthetic activity in a cell-free protein synthesis system using a mammalian cultured cell extract. An eukaryotic translation initiation factor and/or translational regulator are added to a cell-free protein synthesis system comprising an extract prepared from cultured mammalian cells and a template mRNA. These factors are one or more selected from the group consisting of eukaryotic translation initiation factors 4E (eIF4E), 2 (eIF2) and 2B (eIF2B), and eukaryotic translational regulator p97. | 2011-12-08 |
20110300576 | T7 EXPRESSION SYSTEM - The present invention provides an improved prokaryotic cell expression system employing a tightly controlled host strain construct that controls uninduced, leaky expression of proteins while still auto-inducing well. Various aspects of the present invention address and overcome the problem of uninduced basal expression by providing a host strain that comprises a T7 polymerase gene, and mutants thereof, inserted between lac Z and lac Y of the lac operon (a “ZRY” construct), downstream of an otherwise wild-type lac operon control region. | 2011-12-08 |
20110300577 | NOVEL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY, THEIR USES AND PROCESSES FOR THEIR PRODUCTION - The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization. | 2011-12-08 |
20110300578 | NOVEL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY, THEIR USES AND PROCESSES FOR THEIR PRODUCTION - The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization. | 2011-12-08 |