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48th week of 2010 patent applcation highlights part 56
Patent application numberTitlePublished
20100305295PROCESS FOR PRODUCING POLYAMIC ACID SOLUTION AND POLYAMIC ACID SOLUTION - Disclosed is a process for producing a polyamic acid solution by reacting a diamine component consisting essentially of 20 mol % to 80 mol % of p-phenylenediamine and 80 mol % to 20 mol % of diaminodiphenyl ether with a tetracarboxylic acid component consisting essentially of 10 mol % to 60 mol % of 2,3,3′,4′-biphenyltetracarboxylic dianhydride and 90 mol % to 40 mol % of 3,3′,4,4′-biphenyltetracarboxylic dianhydride in a solvent, comprising:2010-12-02
20100305296Catalyst for Producing Polyester and Method for Producing Polyester - The invention relates to an improved linear microdialysis probe comprising a continuous length of flexible tubing (2010-12-02
20100305297ALIPHATIC POLYESTER RESIN AND ITS PRODUCTION METHOD - An aliphatic polyester resin having excellent moldability and its production method are provided. When the amount of specific structural units contained in an aliphatic polyester resin is adjusted to an optimum amount, an aliphatic polyester resin having sufficient melt tension at the time of molding and excellent moldability than in the past and its production method is provided.2010-12-02
20100305298CONDUCTIVE MATERIAL AND MANUFACTURING METHOD THEREOF - Disclosed is a method of manufacturing a conductive coating film having superior chemical resistance or solvent resistance and durability by chemically bonding a resin having an amine group (—NH2010-12-02
20100305299BIPHENYLTETRACARBOXYLIC ACID DIANHYDRIDE AND PROCESS FOR PRODUCING THE SAME, AND POLYIMIDE FORMED FROM THE SAME AND PROCESS FOR PRODUCING THE SAME - To provide a process for producing BPDA whereby high productivity is attained while high purity is maintained.2010-12-02
20100305300Method of Ring-Opening Polymerization, and Related Compositions and Articles - Methods to form a polymer by ring-opening polymerization include reacting, a mixture comprising a monomer, an accelerator, an initiator, and a catalyst comprising a 1,1,1,3,3,3-hexafluoropropan-2-ol-2-yl group to form the polymer. Also disclosed are polymers including a residual amount of the catalyst in an amount greater than 0 weight percent.2010-12-02
20100305301Method And Apparatus For Elastomer Finishing - In the production of elastomers the product obtained from the polymerization process is often in the form of a slurry. Described herein are an apparatus and a process for “finishing” the elastomer, i.e., dewatering and drying the elastomer. The process comprises the steps of obtaining a slurry comprising water and elastomer; passing the slurry through a first dewatering device to produce a wet elastomer crumb, wherein the first dewatering device comprises two dewatering extruders in parallel; passing the wet elastomer crumb through a second dewatering device; and then passing the wet elastomer crumb through a drying device to produce a dried elastomer crumb.2010-12-02
20100305302METHOD OF DRYING A MATERIAL HAVING A COHESIVE PHASE - A method for drying a material such as a polymer hydrogel which passes through a cohesive phase as it dries is disclosed. The method comprises agitating a composition while removing liquid until the solids content of the composition reaches a level at which the composition enters a cohesive phase, halting agitation, removing liquid from the composition in the absence of agitation, and resuming agitation. Practice of the present invention can eliminate the problems associated with adhesion of a material to itself and to process equipment during the cohesive phase.2010-12-02
20100305303INHIBITING AGENT FOR INHIBITION OF ANGIOGENESIS, A METHOD FOR PREPARING THE AGENT, A METHOD FOR MODIFYING THE AGENT AND ITS USE FOR MANUFACTURING A MEDICAMENT FOR TREATING TUMOR - a highly efficient antiangiogenesis agent, which is a polypeptide for inhibition of angiogenesis Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro, connected with a polypeptide containing Arg-Gly-Asp on its one end or two ends is provided. The inhibiting agent can be synthesized or gene engineered. It also relates to a physiochemical method for modifying the antiangiogenesis agent. Polypeptides with weight percentage of 1-70% preferably about 20-50% are mixed with 20%-95% polyethylene glycol, or heparin, or dextran, or polyvinylpyrrolidone, or polyethylene glycol-poly-amino acid copolymer, or palmitic acid or poly-sialic acid or liposomes solutions; preferably about 50-93% of the above modified substances are fully mixed even and shaken at a shaker at 4° C.-40° C., preferably 25° C.-37° C. for more than 10 min, and the modified substances are separated through appropriate methods. Furthermore, it still relates to the use of the above polypeptides and the polypeptide modified substances for manufacturing medicaments for treating human solid tumors.2010-12-02
20100305304NON-NATURAL PROTEINACEOUS SCAFFOLD MADE OF THREE NON-COVALENTLY ASSOCIATED PEPTIDES - The present invention is related to a non-natural, thermodynamically stable, proteinaceous scaffold consisting of three non-covalently associated peptides, wherein each peptide sequence comprises less than fifty amino acid residues and wherein at least 50% of the said residues are substitutable amino acids into at least ten different amino acid residue types. The present invention is further related to a non-natural, triple-stranded, parallel alpha-helical coiled coil scaffold wherein each of the three constituting peptide sequences comprise between 2 and 7 consecutive heptad repeats, wherein at least 50% of the core residues are isoleucines, wherein all non-core residues are alanines, and wherein the constituting peptide sequences remain associated under physical conditions that are significantly different from physiological conditions.2010-12-02
20100305305METHOD FOR PURIFYING FACTOR VIII AND VON WILLEBRAND FACTOR - The purification method includes, starting from a solution selected from (i) a solution containing a mixture of FVIII and FvW, (ii) a solution containing FvW, (iii) a solution derived from a secretion of a non-human animal and (iv) a solution derived from a FVIII-containing plant extract, a step of absorption of FVIII or FvW on an ion-exchange chromatography filter-type membrane.2010-12-02
20100305306NOVEL RECEPTOR TREM (TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND USES THEREOF - Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.2010-12-02
20100305307HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR - In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.2010-12-02
20100305308Lactoferrin - A pure lactoferrin polypeptide containing no more than two metal ions per molecule, or a mixture of the polypeptide and a fragment thereof. The polypeptide or the mixture stimulates skeletal growth and inhibits bone resorption. Also disclosed is a method of treating a bone-related disorder with the polypeptide or the mixture.2010-12-02
20100305309NANODIAMOND PARTICLE COMPLEXES - The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc.2010-12-02
20100305310Multi-Media Affinity Column to Prevent Leaching of Ligands - In an affinity-type purification, ligands dissociated from a packed bed that would otherwise leach into the solution containing the species being purified are captured by a second ligand that resides in a porous barrier downstream from the packed bed, the second ligand exhibiting an affinity-type interaction with the dissociated first ligand with sufficient specificity to avoid the undesired retention by the second ligand of species from the liquid sample or source liquid other than the species sought to be purified in the affinity column.2010-12-02
20100305311NANOPARTICLE FOR SEPARATING PEPTIDE, METHOD FOR PREPARING THE SAME, AND METHOD FOR SEPARATING PEPTIDE USING THE SAME, - Disclosed are nanoparticles for use in the isolation of peptides, a method for producing the nanoparticles, and a method for the isolation of peptides using the nanoparticles. The nanoparticles comprise magnetic nanoparticles and thiol-specific functional groups as first functional groups bound to the surfaces of the magnetic nanoparticles to selectively capture cysteine-containing peptides. The nanoparticles allow highly selective isolation of target peptides in a simple and rapid manner. Therefore, the nanoparticles can be applied to research on the treatment of diseases such as cancers.2010-12-02
20100305312Method For The Extraction And Purification Of Nucleic Acids On A Membrane - The invention relates to a method for the extraction and detection of nucleic acids on a membrane, making it possible to identify the microorganisms present in low concentration in a liquid or gaseous medium, as well as a novel lysis composition comprising guanidium chloride and between 0.1 and 1% N-Lauroyl-Sarcosine (NLS) making it possible to implement this method.2010-12-02
20100305313EXTRACTION PROCESS FOR PLANT INGREDIENTS - The present invention relates to a process for the extraction of plant ingredients, which comprises a) comminuting plant material b) adding a solvent to the comminuted plant material c) subjecting the mixture of comminuted plant material and solvent to an ultrahigh temperature treatment at 95-150° C. over a period of 5-300 seconds.2010-12-02
20100305314GEOMETRIC SYNTHESIS OF PORPHYRIN RODS - A method of making a compound of Formula I′2010-12-02
20100305315Process for the preparation of 2-(primary/secondary amino)hydrocarbyl)-carbamoyl-7-oxo-2,6-diaza-bicyclo [3.2.0.]heptane-6-sulfonic acid derivatives - A process for the production of a compound of formula (I) wherein 2010-12-02
20100305316PROCESSES FOR PREPARING (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES THEREOF - The present invention provides processes and intermediates for the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and salts thereof which are useful as serotonin-2C (5-HT2C) receptor agonists for the treatment of, for example, obesity.2010-12-02
20100305317SYNTHESIS OF BIGUANIDINES AND TRIAZINES, AND BIGUANIDINO-ALUMINIUM COMPLEXES AS INTERMEDIATES - Synthesis of biguanidines and triazines, and biguanidino-aluminium complexes as intermediates Compounds of formula (I) or salts thereof, in which R2010-12-02
20100305318Process for the Manufacture of Anagrelide Hydrochloride Monohydrate - The present invention relates to a process for preparation of Anagrelide Hydrochloride Monohydrate.2010-12-02
20100305319METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED - A method of purifying a salt of pemetrexed have a structure of formula (III) by salting-out, wherein if M2010-12-02
20100305320Polymorph, polymorph screening system, and polymorph preparing and screening method - A polymorph, a polymorph screening system, and a polymorph preparing and screening method are disclosed. The polymorph preparing and screening method includes the following steps: providing a plurality of substrates of different materials; causing an organic material to grow crystals on the plurality of substrates through solution-cooling crystallization process, so that a plurality of polymorphs with different characteristics are prepared; and screening the plurality of polymorphs prepared in the previous step to obtain polymorphs with desired characteristics.2010-12-02
20100305321PROCESS FOR CHIRAL RESOLUTION OF 2-SUBSTITUTED 4-SUBSTITUTED 1,3-OXATHIOLANES - The present invention relates to a novel process for the chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes and derivatives thereof. The present invention also relates to novel 2-substituted 4-substituted 1,3-oxathiolanes derivatives.2010-12-02
20100305322Process for the Oxidation of Secondary Amines into the Corresponding Nitroxides - The invention relates to a process for the preparation of secondary nitroxide radicals from their corresponding secondary amines by oxidation with an organic peracid, comprising the steps a) adding to a reaction vessel a secondary amine, optionally together with an organic solvent and in one batch a base selected from the group consisting of alkali metal, alkaline earth metal or ammonium bicarbonates and alkaline earth metal or ammonium carbonates or mixtures thereof in the form of a solid together with water or as an aqueous slurry; b) dosing a peracid under stirring to the reaction mixture in an amount of 1.0 to 2.5 mol per mol of secondary amine; and c) isolating the organic phase.2010-12-02
20100305323CRYSTAL FORMS OF (R)-N-METHYLNALTREXONE BROMIDE AND USES THEREOF - The present invention provides a new forms of (R)—N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.2010-12-02
20100305324PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS OR OBESITY COMPRISING PHENYLTETRAZOLE DERIVATIVE - A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.2010-12-02
20100305325PROCESS FOR THE PREPARATION OF AN ENANTIOMERIC TRISUBSTITUTED 3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE - The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.2010-12-02
20100305326Chemical Fragment Screening and Assembly Utilizing Common Chemistry for NMR Probe Introduction and Fragment Linkage - Disclosed herein are methods related to drug development. The methods typically include steps whereby two chemical fragments are identified as binding to a target protein and subsequently the two chemical fragments are joined to create a new chemical entity that binds to the target protein.2010-12-02
20100305327NITROXYL COMPOUND, AND POLYMERIZATION INHIBITOR AND POLYMERIZATION INHIBITOR COMPOSITION USING SAME - The following compound, inhibitor, and composition are provided: a compound having low volatility, high nitroxyl group concentration, and high polymerization inhibitory activity; a polymerization inhibitor using the compound; and a polymerization inhibitor composition using the compound.2010-12-02
20100305328PROCESS FOR PREPARATION OF PIPERIDINE CARBOXYLIC ACID - Processes for preparing pure tiagabine, a piperidine carboxylic acid, using pharmaceutically acceptable acid addition salts of tiagabine esters are provided. L(+)-tartaric acid, oxalic acid and dibenzoyl L(+)-tartaric acid addition salts of tiagabine esters are also provided. Further, processes for preparing acid addition salts of tiagabine esters are provided.2010-12-02
20100305329Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its Tartrate Salt and Crystalline Forms - Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.2010-12-02
20100305330Process for preparing 2-alkyl-3-halo-6-nitrilpyridine and its carboxylic acid and ester derivatives - A process for preparing 2-alkyl-3-halo-6-nitrilpyridine and its carboxylic acid and ester derivatives by reacting 2-alkyl-3-halo-pyridine N-oxide with dimethyl sulfate, followed by reacting the adduct with alkaline cyanide to obtain the target molecule is disclosed. Further treatment of the nitrile with base to obtain the corresponding acid, and esterification are described as well. The process was scaled up to multi-kilogram level that provided satisfactory output.2010-12-02
20100305331ALPHA KETOAMIDE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS - The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.2010-12-02
20100305332NON-POLAR CAPPED NANO TRANSITION METAL OXIDES AND SULFIDES - The present invention relates to a method for the preparation of a functionalized nano size transition metal oxide or sulfide particle comprising the steps of (a) providing a ternary solvent system comprising a polar solvent, a non-polar solvent and an intermediate solvent allowing miscibility of all three components; (b) providing a mixture of a transition metal salt and a ternary solvent; (c) providing a mixture of a suitable source of oxide or sulfide and the ternary solvent; (d) providing a mixture of a non-polar end capping agent and the non-polar solvent; (e) mixing the mixtures; and (f) recovering the resultant functionalized nano size transition metal oxide or sulfide particle. The invention further relates to non-polar end capped nano sized transition metal oxide or sulfide particle so produced and the use of such particles.2010-12-02
20100305333LIPID CONJUGATED CYCLIC CARBONATE DERIVATIVES, THEIR SYNTHESIS, AND USES - The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N′-disuccinimidyl derivative, resulted in the formation of, isolatable, substituted cyclic [1,3]-dioxan-2-one and [1,3]-dioxan-2-thione compounds. These isolatable cyclic substituted compounds and derivatives thereof may be used for various applications, such as in vaccination.2010-12-02
20100305334METHOD FOR PREPARING A MATERIAL FORMED FROM ARBORESCENT-BRANCHED MOLECULES COMPRISING ASSOCIATIVE GROUPS - The present invention relates to a method of preparing a material formed from arborescent-branched molecules comprising associative groups that includes the following successive steps: (a) the reaction of at least one at least trifunctional compound (A) bearing first and second functional groups with at least one bifunctional compound (B), the functional groups of which are capable of, reacting with the first functional groups of the compound (A); and (b) the reaction of the compound(s) obtained in step (a) with at least one compound (C) bearing, on the one hand, at least one reactive group capable of reacting with the second functional groups of (A) and; on the other hand, at least one given associative group2010-12-02
20100305335Metallocorroles - Metallocorrole complexes of third row transition metals may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications.2010-12-02
20100305336PREPARATION METHOD OF COPOLYMERIZABLE PHOTOINITIATORS - An intermediate for preparing (meth)acrylated photoinitiators according to Formula (I):2010-12-02
20100305337Use Of The PIGD Protein For Catalyzing 1,4-Additions Of 2-Oxoalkanoates To Alpha, Beta-Unsaturated Ketones - The present invention relates to the preparation of compounds of the general formula II2010-12-02
20100305338PROCESS FOR PRODUCING OPTICALLY ACTIVE CIS-SILYL OLEFIN OXIDE COMPOUND - The present invention provides an efficient production method of an optically active cis-silylolefin oxide compound useful as an intermediate for various compounds. A production method of an optically active cis-silylolefin oxide compound by subjecting an optically active cis-silylolefin compound to an asymmetric oxidation with a high enantioselectivity and a high chemical yield by utilizing as a catalyst, an optically active titanium complex of Formula (1), Formula (2):2010-12-02
20100305339METHOD FOR PRODUCING LACTONES FROM DIOLS - The present invention provides a process for preparing lactones from optionally substituted, saturated aliphatic diols having from five to 20 carbon atoms between the two ring-closing hydroxyl groups by catalytic dehydrogenation and cyclization in the liquid phase over at least one catalyst.2010-12-02
20100305340Biocell - Three step process for obtaining a liquid biofuel from cellulose consisting mainly of isomers of methylpyran and methyl tetrahydropyran using N alkyl imidazol chloride as solvent and catalyst - Three step process for obtaining liquid biofuels consisting mainly of isomers of methylpyran and methyl tetrahydropyran from cellulose, hemicelluloses or starch, using in a first step N alkyl imidazol chloride containing a slight excess of hydrochloric acid 37%. This mixture acts as a solvent and catalyst for dissolution and hydrolysis of cellulose and dehydration of glucose to isomers of hydroxymethyl pyranone (HMP).2010-12-02
20100305341PRODUCTION OF STEROLS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable of production of one or more sterol compounds, and compositions which utilize the produced sterol compound(s).2010-12-02
20100305342METHOD FOR THE PREPPARATION OF PHYTOSTEROLS FROM TALL OIL PITCH - A method of preparing phytosterols from tall oil pitch containing steryl esters comprises the steps of converting the steryl esters to free phytosterols while in the pitch to produce a modified pitch containing the free phytosterols; removing light ends from the modified pitch by evaporation to produce a bottom fraction containing the free phytosterols; evaporating the bottom fraction to produce a light phase distillate containing the free phytosterols; dissolving the light phase distillate in a solvent comprising an alcohol to produce a solution containing the free phytosterols; cooling the solution to produce a slurry with the free phytosterols crystallized in the slurry; and, washing and filtering the slurry to isolate the crystallized phytosterols.2010-12-02
20100305343Solid Fatty Alkyl Ester Sulfonate Metal Salt and Method for Producing Powder Thereof with Sharp Particle Size Distribution - A solid fatty acid alkyl ester sulfonate metal salt is disclosed having an endothermic peak area between 50° C. and 130° C. of 50% or more relative to the whole endothermic peak area between 0° C. and 130° C. when determined using a differential scanning calorimeter, A method for producing a fatty acid alkyl ester sulfonate metal salt powder is also disclosed, including a step of pulverizing the solid fatty acid alkyl ester sulfonate metal salt in a pulverizer, with the internal temperature of the pulverizer being adjusted to 30° C. to 50° C.2010-12-02
20100305344PROCESS FOR THE PRODUCTION OF POLYOL BASE CATALYSTS - The present disclosure relates to a process for the production of a base complex catalyst comprising reacting a hydroxide base with a polyalcohol, under vacuum pressure, at a temperature in the range of about 60° C. to about 220° C., wherein the mole ratio of the hydroxide base to the polyalcohol is greater than about 2:1.2010-12-02
20100305345PROCESS FOR PRODUCING FLUORINE-CONTAINING COMPOUNDS - This process for producing fluorine-containing compounds includes liquid-phase fluorination by introducing a raw material compound and fluorine gas into a solvent to replace hydrogen atoms in the raw material compound with fluorine atoms. More specifically, the process for producing fluorine-containing compounds includes (1) promoting fluorination by dissolving the raw material compound in anhydrous hydrofluoric acid and introducing into a liquid-phase fluorination solvent, or (2) promoting fluorination by dissolving the raw material compound in a perfluoro compound having a plurality of polar groups in a molecule thereof and introducing into a liquid-phase fluorination solvent. According to these processes, a fluorination reaction can be carried out at high yield and without containing hardly any isomers while using a hydrocarbon compound as is for the raw material.2010-12-02
20100305346METHOD FOR PRODUCING FATTY ACID MONOESTERIFIED PRODUCT USING SOLID ACID CATALYST - The present invention provides a method for producing a fatty acid monoester product by reacting an animal oil and/or a vegetable oil with an alcohol in the presence of a sulfonic acid group-introduced amorphous carbon catalyst and water. By this method, the production of a fatty acid monoglyceride, which is difficult to separate from the fatty acid monoester, can be suppressed, and the fatty acid monoester can be efficiently produced.2010-12-02
20100305347PROCESS FOR SEPARATING SATURATED AND UNSATURATED FATTY ACIDS - A process for separating a blend of saturated and unsaturated fatty acids or saturated and unsaturated fatty acid alky esters into a first fraction enriched with the saturated fatty acids or saturated fatty acid alkyl esters and a second fraction enriched with unsaturated fatty acids or unsaturated fatty acid alkyl esters. When separating fatty acids, the process includes the steps of (a) saponifying a blend of long chain saturated and unsaturated fatty acids to form free fatty acids, (b) complexing the free fatty acids with urea, and (c) separating the urea complexed free fatty acids into a first fraction enriched with saturated free fatty acids and a second fraction enriched with unsaturated free fatty acids. When separating fatty acid alkyl esters, the process includes the steps of (i) complexing the fatty acid alkyl esters with urea, and (ii) separating the urea-complexed fatty acid alkly esters into a first fraction enriched with saturated fatty acid alkyl esters and a second fraction enriched with unsaturated fatty acid alkyl esters.2010-12-02
20100305348METHOD FOR THE PRODUCTION OF BETA-KETOCARBONYL-FUNCTIONAL ORGANOSILICON COMPOUNDS - β-ketocarbonyl-functional organosilicon compounds are prepared by reacting an organosilicon compound containing at least one primary amino group with a compound which liberates a diketene, the reaction taking place in the presence of an organic compound which inhibits or prevents the reaction of diketenes with primary or secondary amino groups. The products are different from those produced merely by the reaction of a diketene with an amino-group-containing organosilicon compound.2010-12-02
20100305349PROCESS FOR PREPARING A COMPLEX - The present invention provides a process for the preparation of a complex of formula (A) or (B):2010-12-02
20100305350DIAMIDINE METAL COMPLEX AND METHOD OF USE - A diamidine compound is used to complex to a catalytic metal atom. This can be dissolved in an organic solution for homogenous catalytic reactions, such as a hydrogenation, polymerization reaction. The metal complex can be separated from the reactant solution after the reaction by bubbling carbon dioxide through the solution causing the formation of diamidinium bicarbonate, which is insoluble in organic solution and can be recovered in an aqueous medium. The diamidinium bicarbonate can be further converted back into an organic soluble diamidine by bubbling the aqueous solution with argon or nitrogen, permitting the reuse of the catalyst in homogeneous catalytic reactions.2010-12-02
20100305351CHEMICAL COMPOUNDS - A fungicidal compound of formula (I):2010-12-02
20100305352METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE ALPHA ALKYL CARBONYL COMPOUNDS - A method for the production of optically active α-alkylcarbonyl compounds with retention of the stereo information of the starting compound. The starting compound used here is a carbonyl compound which has, in the α-position, a leaving group which is substituted by an alkyl group with inversion of the configuration. The substitution of the leaving group is effected with the use of an alkylmagnesium Grignard and a zinc (II) salt or a zinc organyl. The method permits the production of optically active α-alkylcarbonyl compounds at very mild temperatures (for example 0° C.) with the use of starting compounds which are easy to prepare and economical and nontoxic catalysts, it also being possible to achieve a very high yield.2010-12-02
20100305353METHOD FOR PRODUCING PURIFIED FORMYLCYCLOPROPANE COMPOUND AND INTERMEDIATE OF SUCH FORMYLCYCLOPROPANE COMPOUND - A method for producing a purified formylcyclopropane compound represented by the formula (1) comprising (A) a step of reacting a crude formylcyclopropane compound represented by the formula (1):2010-12-02
20100305354METHOD FOR THE SYNTHESIS OF DIACIDS OR DIESTERS FROM NATURAL FATTY ACIDS AND/OR ESTERS - The invention relates to a process for the synthesis of diacids or diesters of general formula ROOC—(CH2010-12-02
20100305355METHOD OF REMOVING HEAVY HYDROCARBONS FROM REACTION PRODUCTS IN THE PRODUCTION OF SEC-BUTYL ACETATE - The present invention relates to a method of removing heavy hydrocarbon from reaction products in producing sec-butyl acetate, characterized in that the method comprises: drawing out materials from the enrichment area of the heavy hydrocarbon; contacting the materials with water sufficiently to make the heavy hydrocarbon in materials and the water stratify naturally wherein the heavy hydrocarbon is contained in the upper layer and the water is contained in the lower layer; and discharging the upper layer and recycling the lower layer into the system. The enrichment area of heavy hydrocarbon refers to the area enriched with heavy hydrocarbon and formed in the bottom of an azeotropic distillation tower during the process of azeotropic separation, while the process of azeotropic separation refers to a process of feeding the mixture of sec-butyl acetate, acetate acid and heavy hydrocarbon into the azeotropic distillation tower and adding azeotropic agent into the azeotropic distillation tower to conduct azeotropic distillation, then evaporating the azeotropic mixture formed by sec-butyl acetate and azeotropic agent from the top of the azeotropic distillation tower, and meanwhile, the acetic acid and the heavy hydrocarbon falling into the bottom of the tower.2010-12-02
20100305356METHOD FOR PRODUCING ISOCYANATES - The present invention relates to a process for preparing isocyanates.2010-12-02
20100305357Optimized Liquid-Phase Oxidation - Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reaction at relatively low temperatures. When the oxidized compound is para-xylene and the product from the oxidation reaction is crude terephthalic acid (CTA), such CTA product can be purified and separated by more economical techniques than could be employed if the CTA were formed by a conventional high-temperature oxidation process.2010-12-02
20100305358Method For The Production Of Acyl Glycinates By Means Of Direct Oxidation - A method is described for producing acyl glycinate salts of formula (II)2010-12-02
20100305359Processes For Preparing A Substituted Gamma-Amino Acid - The present invention is related to processes suitable for industrial synthesis of pregabalin from (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic using sodium hypochlorite as described herein. In addition, the present invention is related to pregabalin which is substantially free of impurities and pharmaceutical compositions comprising pregabalin.2010-12-02
20100305360Purification of acetic acid from wood acetylation process using extraction - There is shown a method of purifying glacial acetic acid containing terpene and terpenoid impurities. Substantially dry acetic acid containing terpene and terpenoid impurities is combined with water and a suitable organic solvent, which is substantially immiscible with acetic acid and water, to form a separating composite extraction medium having a weight ratio of acetic acid:water of at least 1:1. The components are separated into an organic phase and an aqueous acid phase, with the terpene and terpenoid impurities concentrated in the organic phase, and with the aqueous acid phase purified of terpene and terpenoid impurities. The purified aqueous acid phase is recovered, and the purified acetic acid is dried.2010-12-02
20100305361MACROMOLECULAR ANTIOXIDANTS BASED ON STERICALLY HINDERED PHENOLS AND PHOSPHITES - Sterically hindered phenol and phosphite based compounds represented by structural formula II:2010-12-02
20100305362AMINOALKYL VINYL ETHERS COMPRISING ETHYLENIMINE UNITS, PROCESSES FOR THEIR PREPARATION AND THEIR USE - Aminoalkyl vinyl ethers comprising alkylenimine units and of the formula2010-12-02
20100305363REACTION APPARATUS - A reaction apparatus which is used for conducting a gas-liquid chemical reaction in a state that a liquid is in a continuous phase, wherein its reactor has therein a shear type stirring impeller for dispersing a raw reaction gas or a carrier gas and a film-formed catalyst, which apparatus is capable of producing a target reaction product; and a process for producing a tertiary amine in such reaction apparatus.2010-12-02
20100305364PROCESS FOR PREPARING DIISOPROPYL((1-(HYDROXYMETHYL)-CYCLOPROPYL)OXY)METHYLPHOSPHONATE - The present invention relates to a new process for preparing diisopropyl {[1-(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate (2), which is a key intermediate for synthesizing an antiviral (particularly, against hepatitis B virus) nucleoside analogue. The present invention also relates to new intermediates, and a process for preparing the antiviral nucleoside analogue from the compound (2) prepared according to the present invention.2010-12-02
20100305365REGENERATION OF ACIDIC ION EXCHANGERS - The invention relates to a method for regenerating acidic cation exchangers, which are used as catalysts in the reaction of phenols with aldehydes or ketones to give bisphenols, in particular to give bisphenol A, with acids, with the proviso that, in the method according to the invention, these cation exchangers experience very little mechanical damage due to swelling processes during the regeneration process.2010-12-02
20100305366Lutein Extraction Processes - A lutein extraction process comprises pulverizing marigold, adding organic solvent in the former, then placing into an ultrasonic extraction vessel for ultrasonic extraction, filtering the extracted solution, and recovering to obtain a filtrate containing lutein ester; adding an alkaline solution that is 2 times of the filtrate volume in the filtrate recovered in the above step, and performing saponification on the lutein ester in the filtrate at 50-70° C.; washing the resultant after saponification with deionized water until lutein crystallization occurs, centrifuging the solution containing the lutein crystals to obtain crude crystals of lutein; subjecting the crude crystals of lutein to recrystallization; washing the lutein crystals obtained by recrystallization, and drying to obtain lutein crystal product. The ultrasonic extraction method in the present invention utilizes ultrasonic wave-induced intensive vibration, high acceleration, intensive cavitation effect, and stirring action to accelerate entrance of lutein into solvent, so as to increase extraction rate of effective components and shorten the extraction time.2010-12-02
20100305367Process for Manufacturing a Chlorohydrin - A process for manufacturing a chlorohydrin by reacting a polyhydroxylated-aliphatic hydrocarbon, an ester of a polyhydroxylated-aliphatic hydrocarbon, or a mixture thereof with a chlorinating agent in a reactor containing a liquid reaction medium wherein the chlorinating agent is used at least partially in the gaseous form, and wherein said reactor is stirred by means of a stirring system comprising at least one radial-flow impeller and at least one axial-flow impeller.2010-12-02
20100305368Combined Formose/Transfer Hydrogenation Process for Ethylene Glycol Synthesis - The present invention provides a process for the production of a glycol via tandem self condensation of formaldehyde via formoin condensation and transfer hydrogenation of the reaction products of the formoin condensation. In some aspects, synthetic processes of the present invention utilize a combination of a N-heterocyclic carbene catalyst and a transition metal hydrogen-transfer catalyst providing enhanced selectivity and increased yields for the production of ethylene glycol relative to conventional synthetic approaches based on formoin condensation.2010-12-02
20100305369PROCESS FOR THE PREPARATION OF AN OLEFIN OXIDE - The present invention relates to a continuous process for the preparation of an olefin oxide wherein an olefin is reacted with a hydroperoxidein the presence of a catalyst, and wherein the reaction which is carried out in at least three reactors operated in parallel is controlled by specifically adjusting the catalyst loads in the reactors.2010-12-02
20100305370METHOD FOR PREPARING 2,3,3,3-TETRAFLUORO-1-PROPENE - The invention relates to a gas-phase continuous method for preparing 2,3,3,3-tetrafluoro-1-propene, said method comprising the following steps: (i) hydrogenation of hexafluoropropylene to form 1,1,1,2,3,3-hexafluoropropane; (ii) dehydrofluorination of the 1,1,1,2,3,3-hexafluoropropane obtained in the previous step to 1,2,3,3,3-pentafluoropropene-1; (iii) hydrogenation of the 1,2,3,3,3-pentafluoropropene-1 obtained in the previous step to form 1,1,1,2,3-pentafluoropropane; and (iv) dehydrofluorination of the 1,1,1,2,3-pentafluoropropane obtained in the previous step to form 2,3,3,3-tetrafluoro-1-propene.2010-12-02
20100305371PRODUCTION PROCESSES FOR MAKING 1,1,1,2,2,3-HEXAFLUOROPROPANE - A process for making HFC-236cb is disclosed. The process comprises reacting TFE with HFC-32 in the presence of at least one co-product and a suitable catalyst to produce a product mixture comprising HFC-236cb, wherein the total amount of the at least one co-product is at least 10 ppmv based on the total amount of the tetrafluoroethylene, the difluoromethane and the at least one co-product.2010-12-02
20100305372SYSTEM FOR RECYCLING PLASTICS - One embodiment of a method of recycling a plastic material includes heating a plastic material in a treatment chamber in incremental steps through a series of graduated temperature set points wherein each graduated temperature set point corresponds to a vaporization temperature of an individual by-product of said plastic material, and pulling a vacuum of inert gas on the treatment chamber at each temperature set point to selectively remove an individual by-product corresponding to the temperature set point.2010-12-02
20100305373PROCESS FOR OBTENTION OF HIGHLY-LINEAL, ADJUSTABLE-ISOMERY MONOALKYLATED AROMATIC COMPOUNDS - The present invention refers to a procedure for obtaining a linear monoalkylaromatic compound, with adjustable 2-phenyl isomer content and an extremely low sulphonation color, in which a catalytic system is used based on highly stable and active solid catalysts and with a high selectivity for linear monoalkylaromatic compounds.2010-12-02
20100305374Production Of Aromatics From Methane - In a process for converting methane to aromatic hydrocarbons, a feed containing methane is supplied to one or more reaction zone(s) containing catalytic material operating under reaction conditions effective to convert at least a portion of the methane to aromatic hydrocarbons; the reaction zone(s) being operated with an inverse temperature profile.2010-12-02
20100305375PROCESS FOR THE PREPARATION OF AN OLEFINIC PRODUCT - Process for the preparation of an olefinic product, which process comprises reacting an oxygenate feedstock and an olefinic co-feed in a reactor in the presence of an oxygenate conversion catalyst comprising a molecular sieve having one-dimensional 10-membered ring channels, and a further molecular sieve having more-dimensional channels, wherein the weight ratio between the one-dimensional molecular sieve and the further molecular sieve is in the range of from 1:1 to 100:1, to prepare an olefinic reaction effluent; separating the olefinic reaction effluent into at least a first olefinic fraction and a second olefinic fraction; recycling at least part of the second olefinic fraction; and recovering at least part of the first olefinic fraction as olefinic product.2010-12-02
20100305376PROCESS AND PLANT FOR PRODUCING SYNTHETIC FUELS - In a process for producing synthetic fuels from an educt mixture containing hydrogen and oxygenates, such as methanol and/or dimethyl ether, the educt mixture is reacted on a catalyst in a first process stage to obtain a hydrocarbon product containing olefins with preferably 2 to 8 carbon atoms. In a second process stage the hydrocarbon product is oligomerized to long-chain olefins, from which gasoline and Diesel products are obtained. The hydrocarbon product obtained in the first process stage is separated into a liquid phase and a gaseous phase. The gaseous phase is supplied to the second process stage. The liquid phase is separated into a mixture rich in C2010-12-02
20100305377PROCESS FOR THE PREPARATION OF AN OLEFIN - An olefin is prepared from an alkyl alcohol in a process, comprising the steps: a) converting the alkyl alcohol into a dialkylether over a first catalyst, to yield a dialkylether product stream containing alkyl alcohol, dialkylether and water; b) separating the dialkylether product stream into a vaporous dialkylether-rich stream and a liquid water-containing stream which water-containing stream comprises at most 5% wt of alkyl alcohol, based on the total weight of water and alkyl alcohol; and c) converting the vaporous dialkylether-rich stream to an olefin over a second catalyst, wherein the dialkylether product stream is enriched with a base.2010-12-02
20100305378Aromatic Alkylation Process - The present invention is for a process for the alkylation of aromatic compounds, with a shape-selective zeolite catalyst. The process has reactors in series with C2010-12-02
20100305379Transalkylation of Heavy Alkylate Using a Layered Catalyst - A layered catalyst is disclosed for use in transalkylation of polyalkylated benzenes. The catalyst comprises an inner core material with a molecular sieve bonded over the core. The process minimizes the cracking of the alkyl groups during the transalkylation reaction.2010-12-02
20100305380Process for Improved Meta-Xylene Yield from C8 Aromatics - Meta-xylene is recovered from admixture with other C2010-12-02
20100305381Parex Unit Feed - A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.2010-12-02
20100305382METHOD FOR OBTAINING AROMATIC HYDROCARBONS FROM A HYDROCARBON MIXTURE - The invention relates to a process for obtaining aromatic hydrocarbons selected from benzene, toluene, xylene and ethylbenzene mixtures thereof from a hydrocarbon mixture which additionally comprises nonaromatic hydrocarbons and high boilers, comprising the steps of2010-12-02
20100305383Systems and Methods for Reducing the Storage Time of Spent Nuclear Fuel - Systems and methods are provided for reducing the storage time of spent nuclear fuel. In one embodiment, a method is provided that includes providing a sample of spent nuclear fuel and irradiating the spent nuclear fuel with substantially collimated gamma ray photons having energy levels of about 10 MeV to about 15 MeV for a predetermined time period to initiate a photofission reaction in the remaining fertile fissile material in the spent nuclear fuel.2010-12-02
20100305384Process for Converting Alkaline-Earth Metal Chlorides to Tungstates and Molybdates and Applications Thereof - The invention relates to a process for converting an alkaline-earth metal chloride to at least one salt chosen from the tungstates and molybdates of this metal, which comprises the reaction of the alkaline-earth metal chloride with at least one precursor of tungsten or of molybdenum chosen from tungsten oxides, molybdenum oxides, tungstates and molybdates, this reaction being carried out in a solvent constituted by KCl or by an LiCl/KCl mixture and at a temperature at least equal to the melting point of this solvent.2010-12-02
20100305385Decontamination of sediments through surface charge modification and encapsulation - Composition and process of encapsulation of sediment particles to reduce active pollutant components through surface charge modification.2010-12-02
20100305386 METHOD OF DETOXIFYING A HARMFUL COMPOUND - It is an object of the present invention to provide a beneficial method for detoxifying a harmful compound to detoxify the harmful compound containing arsenic etc., effectively.2010-12-02
20100305387COMPOSITIONS, MATERIALS INCORPORATING THE COMPOSITIONS, AND METHODS OF USING THE COMPOSITIONS AND MATERIALS - Compositions, materials incorporating the compositions, and methods of use thereof, for the protection and/or decontamination of contaminants are disclosed.2010-12-02
20100305388Apparatus for Transporting and Positioning a Capsule in which a Radioactive Source is Present - An apparatus is described for transporting and positioning a capsule, in which a radioactive source is present, from a screened safe into an applicator to be temporarily placed in the body of the patient. The apparatus is provided with a safe for storing at least one capsule and with a larger number of applicators, which can be connected, via transport tubes, to passages in a switch-connecting plate, wherein the capsules, or a dummy instead of one of the capsules, can each, via their own tube and switch, independently of one another, be introduced into a transport tube selected by the respective switch and can be displaced therein independently of one another in a manner programmable with regard to location and residence time, by a transport wire slidable via a drive motor.2010-12-02
20100305389Device Suitable for Introducing into Human and/or Animal Bodies - The invention relates to a device suitable for at least partially introducing into human and/or animal bodies, said device containing barium iodide located at least on one wall such that the device is visible during an imaging method.2010-12-02
20100305390THERAPEUTIC MEDICAL APPLIANCE DELIVERY AND METHOD OF USE - The present invention, in an exemplary embodiment, provides a therapeutic medical appliance, delivery device and method of use. In particular, plug therapeutic medical appliances are provided that allow for the interventional treatment of pulmonary disorders such as defects characterized by pulmonary blebs and/or diffused destructive parenchymal disease. The plug therapeutic medical appliances themselves combine many of the excellent characteristics of both silicone and metal therapeutic medical appliances while eliminating the undesirable ones. In particular, these therapeutic medical appliances are preferably self-expanding in nature and allow the predetermined differential selection of relative hardness/softness of regions of the therapeutic medical appliance to provide additional patient comfort. An exemplary embodiment also provides a family of delivery devices that facilitate flexibility, durability and/or proper installation of one or more medical appliances in a single procedure. Moreover, the preferred embodiment of the delivery device provides for the reloading of the delivery device with additional medical appliances for additional interventional procedures.2010-12-02
20100305391MAGNOTHERAPY - The present invention relates to the use of magnets in the treatment of medical conditions wherein the magnotherapy product comprises a magnet having positive and negative poles, the magnet having a metallic element which distorts the magnetic field distribution around the magnet so as to attenuate the magnetic field in the vicinity of the positive pole of the magnet. The invention also relates to methods of treatment using those magnets.2010-12-02
20100305392THORACIC AORTA AND VAGUS NERVE STIMULATION - Apparatus and methods are described including identifying a subject as suffering from a condition selected from the group consisting of congestive heart failure, diastolic heart failure, and hypertension. In response to the identifying, an electrode is placed on a vagus nerve of the subject at a vagal site that is between (a) a vagal bifurcation with a thoracic cardiac branch of the subject, and (b) thoracic vagal branching into the esophageal plexus of the subject. The subject is treated by driving a current into the vagal site, via the electrode. Other embodiments are also described.2010-12-02
20100305393APPARATUS AND METHOD FOR PROVIDING CONTINUOUS ACCESS TO AN ISOLATION SPACE WHILE MAINTAINING ISOLATION - An isolation container includes an isolation space for receiving an object and maintains the isolation space substantially isolated while providing for continuous access to, and maneuverability within, the isolation space through one or more access ports. An air management system re-circulates air through the isolation space to create a negative or positive pressure within the space, and is operable to filter, and optionally adjust the temperature and humidity of, the re-circulating air. In an embodiment of the isolation container configured for transporting a patient in the isolation space, a communications system is also coupled to the isolation space to provide for audio, video or other data communications between the patient and the communications device external to the isolation container.2010-12-02
20100305394TUBULAR MESH FOR SACROCOLPOPEXY AND RELATED PROCEDURES - A sacrocolpopexy mesh that includes lateral support to improve vaginal contact during colpopexy and to prevent slipping.2010-12-02