48th week of 2011 patent applcation highlights part 46 |
Patent application number | Title | Published |
20110294142 | Multiply Fluorescently Labeled Calcium Phosphate-Protein Surfaces - Described herein are multiply-fluorescently-labeled calcium phosphate protein substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating and further having a fluorescently-labeled protein. The multiply-fluorescently-labeled substrate may be a fluorescently labeled calcium phosphate surface having a fluorescently-labeled collagen. The substrates are useful in culturing and studying the activity of a variety of cells, including bone cells. The substrates described herein can be used for both solution- and image-based analysis of cultured cells. New methods for producing and using such coated substrates are also disclosed. | 2011-12-01 |
20110294143 | METHOD FOR DETECTING ALL HAEMOPHILUS INFLUENZAE - Provided is an immunoassay method whereby all | 2011-12-01 |
20110294144 | SCREENING METHOD - The present invention provides a cell model system capable of sufficiently reproducing a series of tau lesions, and provides a screening method for a prophylactic or therapeutic drug for a neurodegenerative disease using phosphorylation, insolubilization or aggregation of tau, or neurite denaturation or cell death in the cell model as an index. | 2011-12-01 |
20110294145 | REAGENTS AND METHODS FOR DETECTING A POLYMORPHIC PROTEIN - The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for testing a subject for susceptibility to diabetic complications. | 2011-12-01 |
20110294146 | Identification of Actinobacillus actinomycetemcomitans Antigens for Use in the Diagnosis, Treatment, and Monitoring of Periodontal Diseases - Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by | 2011-12-01 |
20110294147 | SEROLOGICAL SCREENING FOR HHV-8 INFECTION USING ANTIGEN MIXTURES - The invention provides compositions, methods, and kits for the diagnosis or detection of active, latent, or prior infection with human herpesvirus 8 in a subject sample. | 2011-12-01 |
20110294148 | TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER AND POSTOPERATIVE MARKER FOR MINIMAL RESIDUAL DISEASE OR RECURRENT DISEASE IN PATIENTS WITH A PRIOR HISTORY OF CANCER - The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent cancer after being treated for the primary cancer by determining a parameter representing the post-operative TIMP-1 concentration in body fluid samples from the individual. In addition, the invention describes the additive effect of combined post-operative measurements of plasma TIMP-1 and serum CEA. | 2011-12-01 |
20110294149 | Alzheimer's Disease Secretase, APP Substrates Therefor, and Uses Therefor - The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease. | 2011-12-01 |
20110294150 | IMMUNOGLOBULIN GLYCOSYLATION PATTERN ANALYSIS - The current invention is directed to a method for the determination of the glycosylation pattern of a human immunoglobulin of the subclass IgG1 or IgG4 or of a murine immunoglobulin of the subclass Ig-G2a or IgG3 comprising the following steps: a) cleaving said immunoglobulin into fragments by enzymatic digestion with the enzyme IdeS, b) separating the fragments of said immunoglobulin obtained by the enzymatic digestion by reversed phase high performance liquid chromatography, c) subjecting the separated fragments of said immunoglobulin obtained in step b) to a mass spectrometric analysis, and d) determining the glycosylation pattern of said immunoglobulin from the mass spectrometric data obtained in step c). | 2011-12-01 |
20110294151 | Fluorescently Labeled Calcium Phosphate Surfaces - Described herein are substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating. The substrates are useful in culturing and studying the activity of a variety of cells. The substrates described herein can be used for both solution- and image-based analysis of cultured cells. New methods for producing and using such coated substrates are also disclosed. | 2011-12-01 |
20110294152 | CALIBRATION MATERIAL DELIVERY DEVICES AND METHODS - A device is described that includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. Related arrangements and methods are also described. | 2011-12-01 |
20110294153 | REAGENT AND METHOD FOR DETECTION OF CARBOXYLIC ACIDS BY MASS SPECTROMETRY - Method and reagent for converting a carboxylic acid to a positively charged amide. The method and reagent facilitate positive ion mass spectral analysis of carboxylic acids. | 2011-12-01 |
20110294154 | FLOW CHAMBER AND ANALYTE DETECTION METHOD - A flow chamber and method for detecting the presence of one more cell produced analytes under flow conditions. The flow chamber includes two compartments separated by a permeable membrane on which a plurality of cells may be positioned. The permeable membrane shields one or more analyte sensors positioned one compartment from the convective transport forces of a fluid flow within the other compartment to allow reliable and accurate detection of cell-produced analytes and determination of the concentration of cell-produced analytes. | 2011-12-01 |
20110294155 | MODULATION OF AN ION CHANNEL OR RECEPTOR - This invention relates to a method of assaying a compound for its ability to modulate an ion channel or receptor type, the method comprising: a) providing a dynamic clamp in electrical contact with a biological cell (or part thereof) in which one or more ion channel or receptor types for providing a waveform are functional and in which one or more ion channel or receptor types for providing a waveform are either not present or not functional; b) causing the dynamic clamp to apply a signal simulating the function of at least one of the one or more ion channel or receptor types that are either not present or not functional in the biological cell (or part thereof) based on modulation of the ion channel or receptor types that are functional in the biological cell (or part thereof) to thereby provide the waveform at the biological cell (or part thereof); c) exposing at least one of the one or more functional ion channel or receptor types to a compound; and d) detecting modulation of the waveform at the biological cell (or part thereof), wherein modulation of the waveform is indicative of a compound that modulates the at least one functional ion channel or receptor types. | 2011-12-01 |
20110294156 | NOVEL ANTI CXCR4 ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to a novel isolated antibody, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changed of the CXCR4 homodimers and/or heterodimers. | 2011-12-01 |
20110294157 | METHOD FOR MODIFYING THE PROPERTIES OF A FLUID BY IRRADIATION, AND SYSTEM FOR IMPLEMENTING SAME - Methods for modifying the physical, chemical and/or biological properties of a fluid by irradiation are provided. In one embodiment, a method comprising supplying a flow of a fluid to an irradiation chamber; focusing the flow of the fluid so as to create at least one fluid layer; and applying radiation to the fluid layer in a defined portion of the irradiation chamber thereby modifying at least one physical, chemical or biological property of the fluid layer is provided. Systems for the implementation of such methods are also provided. | 2011-12-01 |
20110294158 | Rapid Detection of Bacteria Using Mass Spectrometric Analysis - Methods for the detection or diagnosis of a bacterial infection or colonisation utilising mass spectrometric analysis are provided. The methods involve short-term enrichment of samples followed by mass spectrometric analysis of biomarker profiles. Also provided are methods for preparing short-term enrichment cultures. | 2011-12-01 |
20110294159 | Biocompatible Article for the Treatment of Water and Production of Energy - A biocompatible article including (a) a biocompatible hydrogel; (b) an adhesive coating on at least a portion of the hydrogel; and (c) one or more organisms adhered to at least a portion of the adhesive coating is disclosed. | 2011-12-01 |
20110294160 | Cysteine Protease Autoprocessing of Fusion Proteins - Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The disclosed fusion proteins include an autoproteolytic cysteine protease fused to a heterologous polypeptide, which may be isolated as the target protein. Preferably, the protease activity of the cysteine protease is inducible. Suitable autoproteolytic cysteine proteases for the fusion proteins include the cysteine protease of the | 2011-12-01 |
20110294161 | Modified Human Growth Hormone - Modified growth hormone polypeptide and uses thereof are provided. | 2011-12-01 |
20110294162 | B-7 RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 2011-12-01 |
20110294163 | Of Enzymatic Hydrolysis Of Pretreated Lignocellulose-Containing Material With Agricultural Residues - A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing agricultural residues to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to one or more hydrolyzing enzymes; and fermenting with a fermenting organism to produce a fermentation product. The agricultural residues may be corn pith and/or corn cob. | 2011-12-01 |
20110294164 | VARIANT HUMICOLA GRISEA CBH1.1 - Disclosed are variants of | 2011-12-01 |
20110294165 | VARIANT HUMICOLA GRISEA CBH1.1 - Disclosed are variants of | 2011-12-01 |
20110294166 | THERMOSTABLE ENZYMES FOR THE HYDROLYSIS OF MANNAN-CONTAINING POLYSACCHARIDES - The present disclosure relates to hydrolysis of mannan-containing poly- or oligo-saccharides by use of a polypeptide having endo-β-mannanase activity. In particular the present disclosure relates to compositions comprising a bacterial endo-β-mannanase, polynucleotides encoding the endo-β-mannanase, and methods of use thereof. | 2011-12-01 |
20110294167 | NUCLEIC ACID AMPLIFICATION - The present invention provides improved systems and methods for amplifying nucleic acids. Among other things the present invention provides a system for amplifying nucleic acids through use of a primase and a polymerase with strand-displacement ability without, for example, exogenously-added primers. The present invention is particularly useful for whole genome amplification. | 2011-12-01 |
20110294168 | DNA POLYMERASES AND RELATED METHODS - Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors. | 2011-12-01 |
20110294169 | LIGNOCELLULOSIC TREATMENTS AND APPLICATIONS THEREOF - In one aspect, methods of treating lignocellulosic materials are described herein. In some embodiments, a method of treating a lignocellulosic material comprises degrading lignin of the lignocellulosic material with at least one fungus and hydrolyzing cellulose of the lignocellulosic material with at least one microorganism. | 2011-12-01 |
20110294170 | Pentose Fermentation By a Recombinant Microorganism - The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods. | 2011-12-01 |
20110294171 | PREPARATION OF A SATURATED ALDEHYDE - The invention relates to a compound according to Formula (IX) | 2011-12-01 |
20110294172 | USE OF IONIC LIQUIDS FOR IMPLEMENTING A PROCESS FOR THE PREPARATION OF BIODIESEL - The use of a combination of—at least one ionic liquid which is lipophilic, and non miscible with water, and—at least one enzyme, for the implementation of an esterification and/or transesterification process of a substrate with at least one alcohol, the substrate consisting of oils, fats, fatty acids, or a mixture thereof, wherein the ionic liquid, the substrate, and the alcohol form a single homogeneous liquid phase at the temperature at which the esterification and/or transesterification process is performed. | 2011-12-01 |
20110294173 | Process and Microorganisms for Production of Lipids - The present invention provides a process for producing lipids for biofuel or lubricant and | 2011-12-01 |
20110294174 | Tailored Oils Produced From Recombinant Heterotrophic Microorganisms - Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a keto acyl-ACP synthase enzyme, a fatty acyl-ACP thioesterase, a fatty acyl-CoA/aldehyde reductase, a fatty acyl-CoA reductase, a fatty aldehyde reductase, a fatty aldehyde decarbonylase, and/or an acyl carrier protein are useful in manufacturing transportation fuels such as renewable diesel, biodiesel, and renewable jet fuel, as well as oleochemicals such as functional fluids, surfactants, soaps and lubricants. | 2011-12-01 |
20110294175 | INTEGRATED PROCESS FOR THE PRODUCTION OF BIO-OIL FROM MICRO-ORGANISMS - The cultivation of heterotrophic and phototrophic micro-organisms is integrated for the production of bio-oil for biofuels, wherein the overall algal suspension produced is first thickened, with recirculation of the excess water to cultivation containers, and then thermally treated at a high temperature. After cooling, a bio-oil phase is recovered together with a suspension rich in soluble carbohydrates and proteins which forms a nutritional/energy source for heterotrophic micro-organisms. | 2011-12-01 |
20110294176 | METHOD OF EXTRACTING BUTYRIC ACID FROM A FERMENTED LIQUID AND CHEMICALLY CONVERTING BUTYRIC ACID INTO BIOFUEL - Disclosed is a method of converting butyric acid contained in a fermentation broth into biofuel. This chemical conversion method includes separating biohydrogen from gases generated in the course of production of butyric acid through fermentation of carbohydrate, extracting butyric acid from the broth using an insoluble solvent, esterifying butyric acid thus producing butylbutyrate, and hydrogenolyzing all or part of butylbutyrate, thus obtaining butanol. Thereby, biobutanol can be efficiently and economically produced, and butylbutyrate, which has oxidation stability superior to that of conventional biodiesel (fatty acid methyl ester) and is thus regarded as novel biofuel, can be produced together. | 2011-12-01 |
20110294177 | OPTIMISED FERMENTATION MEDIA - The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of substrates comprising CO. It more particularly relates to the provision of an improved fermentation media, comprising nickel, to a fermentation system such that one or more micro-organisms convert a substrate comprising CO to one or more alcohols, such as ethanol. In particular embodiments, a microbial culture is provided with at least 10 μM nickel, such that CO uptake by the microbial culture increases and ethanol productivity improves. | 2011-12-01 |
20110294178 | METHOD FOR THE PREPARATION OF DIOLS - The present invention concerns a new method for the biological preparation of a diol comprising culturing a microorganism genetically modified for the bioproduction of an aliphatic diol, wherein the microorganism comprises a metabolic pathway for the decarboxylation of a hydroxy-2-keto-aliphatic acid metabolite with an enzyme having a 2-keto acid decarboxylase activity, the product obtained from said decarboxylation step being further reduced into the corresponding aliphatic diol, and wherein the microorganism is genetically modified for the improved production of said hydroxy-2-keto-aliphatic acid metabolite. | 2011-12-01 |
20110294179 | METHOD FOR PRODUCING BUTANOL USING TWO-PHASE EXTRACTIVE FERMENTATION - A method of making butanol from at least one fermentable carbon source that overcomes the issues of toxicity resulting in an increase in the effective titer, the effective rate, and the effective yield of butanol production by fermentation utilizing a recombinant microbial host wherein the butanol is extracted into specific organic extractants during fermentation | 2011-12-01 |
20110294180 | SACCHAROMYCES STRAIN WITH ABILITY TO GROW ON PENTOSE SUGARS UNDER ANAEROBIC CULTIVATION CONDITIONS - The invention relates to an improved | 2011-12-01 |
20110294181 | PROCESS FOR THE PRODUCTION OF ALCOHOL - The invention provides a process for producing alcohol from a cellulosic material, said process comprising the steps of: (i) hydrolyzing said cellulosic material with an aqueous acid to produce a hydrolysate; (ii) extracting acid and water from said hydrolysate with a water-miscible organic extraction solvent to yield (a) a first aqueous acidic solution containing said extraction solvent and (b) a residue containing sugars, (iii) subjecting said residue to an oligosaccharide cleavage reaction to yield an aqueous solution of fermentable sugars; (iv) fermenting said fermentable sugars and distilling alcohol from the resulting fermented mixture; (v) evaporating said extraction solvent from said first solution to yield (a) a second aqueous acid solution containing no more than 10% wt., preferably no more than 5% wt., of said extraction solvent and (b) gaseous extraction solvent; (vi) condensing said gaseous extraction solvent for recycling; and, optionally, (vii) concentrating said second aqueous acid solution for recycling; wherein said extraction solvent is liquid at the temperature and pressure of step (ii), has a boiling point of from 25 to 60° C. at a pressure in the range 1 to 8 bar, and is such that water-soluble oligosaccharides are precipitated from solution by its addition in step (ii). | 2011-12-01 |
20110294182 | Botryoccocus braunii Triterpene Synthase Proteins and Nucleic Acid Molecules, and Methods for Their Use - This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules, transformed hosts and encoded proteins to produce high levels of triterpene hydrocarbons. | 2011-12-01 |
20110294183 | Modified Host Cells with Efflux Pumps - The present invention provides for a modified host cell comprising a heterologous expression of an efflux pump capable of transporting an organic molecule out of the host cell wherein the organic molecule at a sufficiently high concentration reduces the growth rate of or is lethal to the host cell. | 2011-12-01 |
20110294184 | CELLULOLYTIC POLYPEPTIDES AND THEIR USE IN MICRO-ORGANISMS FOR THE PRODUCTION OF SOLVENTS AND FUELS - The invention relates to applications of a cellulase of | 2011-12-01 |
20110294185 | MAGNETIC PLATFORMS FOR BIOMOLECULE TRAPPINGS, MANIPULATIONS, AND SORTING - A magnetic platform is provided and includes a patterned array of discrete magnetic elements positioned on a substrate, a plurality of first electromagnets for creating a first magnetic field substantially in the plane of the substrate, an electromagnetic coil for creating a second magnetic field substantially perpendicular to the plane of the substrate, and a control device for controlling the application of the magnetic fields. Processes for manipulating, transporting, separating and sorting micro- or nano-scale particles and biomolecules are also described. | 2011-12-01 |
20110294186 | DEVICES AND METHODS FOR ENRICHMENT AND ALTERATION OF CIRCULATING TUMOR CELLS AND OTHER PARTICLES - The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject. | 2011-12-01 |
20110294187 | CAPTURING PARTICLES - Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms microvortices in the fluid; contacting at least some of the particles against an adherent disposed on one or more of walls of the microchannel after the microvortices form in the fluid; and capturing at least some of the particles contacting the adherent. | 2011-12-01 |
20110294188 | Ideotypically Modulated Pharmacoeffectors For Selective Cell Treatment - In a method embodiment, a method includes introducing a plurality of Ideotypically Modulated Pharmacoeffectors (IMP) into a population of cells. Each IMP may include a detection domain and an activation domain. One or more epitopes is bound by the detection domain. The activation domain is activated in response to the binding. Applications may include but are not limited to viral infections, other intracellular infections, cancers, vector-borne diseases, autoimmune diseases, cellular diseases, cellular enhancement, and research. | 2011-12-01 |
20110294189 | BIOMOLECULE POLYMER CONJUGATES AND METHODS FOR MAKING THE SAME - Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from defined sites on the biomolecule. The conjugates may have desirable pharmacological properties and may be used therapeutically. | 2011-12-01 |
20110294190 | MUTANT HUMAN SUPEROXIDE DISMUTASE 1 VARIANTS - The present invention in the art of biochemistry claims novel and non-naturally occurring engineered mutant “human superoxide dismutase 1” (hsod1) variant polypeptides, their encoding nucleic acids, and recombinant cells thereof. The inventor rationally engineered mutant hsod1 variants using structural observations and complimentary experimentation. The engineered mutant hsod1 variant products claimed have multiple potential industrial applications, including as novel therapeutics. | 2011-12-01 |
20110294191 | INCREASED PRODUCTION OF ASPARTIC PROTEASES IN FILAMENTOUS FUNGAL CELLS - Described are compositions and methods relating to filamentous fungal cells genetically engineered to provide increased production of aspartic proteases, such as PEPAa, PEPAb, PEPAc, and PEPAd. Also described are nucleic acids and methods for making the engineered filamentous fungal cells. | 2011-12-01 |
20110294192 | FUSION COLLAGENASE IN WHICH AFFINITY TAG IS LINKED AND METHOD FOR PRODUCING THE SAME - A fusion collagenase in which an affinity tag is added to the carboxyl terminal of a collagenase was expressed as a recombinant protein. It was found that a collagenase having a collagen-binding domain can be selectively collected by purifying the obtained fusion collagenase by affinity chromatography. | 2011-12-01 |
20110294193 | VIRAL VECTORS AND METHODS FOR PRODUCING AND USING THE SAME - A recombinant hybrid virus, including: (a) a deleted adenovirus vector genome comprising the adenovirus 5′ and 3′ cis-elements for viral replication and encapsidation, and further comprising a deletion in an adenovirus genomic region selected from the group consisting of: (i) the polymerase region, wherein said deletion essentially prevents the expression of a functional polymerase protein from said deleted region and said hybrid virus does not otherwise express a functional polymerase protein, (ii) the preterminal protein region, wherein said deletion essentially prevents the expression of a functional preterminal protein from said deleted region, and said hybrid virus does not otherwise express a functional preterminal protein, and (iii) both the regions of (i) and (ii); and (b) a recombinant adeno-associated virus (AAV) vector genome flanked by the adenovirus vector genome sequences of (a), said recombinant AAV vector genome comprising (i) AAV 5′ and 3′ inverted terminal repeats, (ii) an AAV packaging sequence, and (iii) a heterologous nucleic acid sequence, wherein said heterologous nucleic acid sequence is flanked by the 5′ and 3′ AAV inverted terminal repeats of (i). Methods of making and using the recombinant hybrid virus are also disclosed. | 2011-12-01 |
20110294194 | EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 2B - The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analyses. | 2011-12-01 |
20110294195 | EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 7a - Genotype 7a has been identified recently, thus not much is known about the biology of this new, major HCV genotype. The present inventors developed hepatitis C virus 7a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 7a strain QC69 and characterized them in Huh7.5 cells. Sequence analysis of 7a/JFH1 recombinants recovered after viral passage in Huh7.5 cells following 4 independent transfection experiments revealed adaptive mutations in Core, E2, NS2, NS5A and NS5B. In reverse genetic studies the importance of these mutations for improved growth kinetics was shown. Adapted 7a/JFH1 viruses showed growth kinetics, infectivity and RNA titers comparable to a previously developed 3a/JFH1 reference virus. Conclusion: The developed 7a/JFH1 viruses provide a robust in vitro tool for research in HCV genotype 7, including vaccine studies and functional analyses. | 2011-12-01 |
20110294196 | METHODS AND SYSTEMS FOR PRODUCING LIPIDS FROM MICROALGAE USING CULTURED MULTI-SPECIES MICROALGAE - The present invention provides a system and method for culturing a microalgae biofamily to produce lipids. The method includes growing a microalgae biofamily comprises multiple microalgae species in a liquid medium at a first stress level. A portion of the microalgae are exposed to a second stress level and harvested. Lipids are extracted from the harvested portion. Also disclosed is a system for culturing a microalgae biofamily that comprises an enclosed pond containing microalgae in growth medium and having a sloped bottom, at least one photobioreactor positioned above the pond, and a pump circulating the microalgae-containing growth medium between the pond and the at least one photobioreactor. | 2011-12-01 |
20110294197 | MODULE FOR DETECTING ANALYTES IN FLUIDS AND CHIP HAVING THE SAME - Disclosed is a module for rapidly detecting analytes in fluids with high effectiveness and a chip having the module. The module includes a microchannel, which has a filtering zone for removing noise materials and a reaction zone wherein labeling reaction and immobilization reaction for detection of analytes are performed, sample fluid moving through the microchannel due to capillary floating. In a case where the chip having the module is used in detecting analytes in fluids, it is possible to minimize dead volume of sample fluid so that high effective volume ratio can be implemented. Therefore, the chip can be used in detecting analytes from the minimum amount of sample fluid. | 2011-12-01 |
20110294198 | DISPOSABLE CHAMBER FOR ANALYZING BIOLOGIC FLUIDS - An apparatus for analyzing biologic fluid is provided that includes first and second planar members, and at least three separators. At least one of the first planar member and second planar member is transparent. The separators are disposed between the planar members, and each individually has a height. The separators collectively having a mean height, and separate the planar members to form a chamber having a height extending between the planar members. At least one of the first planar member, second planar member, or separators is sufficiently deformable when the first planar member and second planar member are drawn toward each other by capillary force from a biologic fluid quiescently residing within the chamber to cause the mean chamber height to be substantially equal to the mean height of the separators. | 2011-12-01 |
20110294199 | APPARATUS FOR POINT-OF-CARE DETECTION OF NUCLEIC ACID IN A SAMPLE - Provided herein are methods and apparatus for detecting a target nucleic acid in a sample and related methods and apparatus for diagnosing a condition in an individual. The condition is associated with presence of nucleic acid produced by certain pathogens in the individual. | 2011-12-01 |
20110294200 | VIRTUAL SEPARATION OF BOUND AND FREE LABEL IN A LIGAND ASSAY FOR PERFORMING IMMUNOASSAYS OF BIOLOGICAL FLUIDS, INCLUDING WHOLE BLOOD - Detection and characterization of immunologically detected substances are performed electronically on human and animal biological fluids such as whole blood, serum, plasma, urine, milk, pleural and peritoneal fluids, and semen, which fluids are contained in a thin chamber forming a quiescent fluid sample, which chamber has at least two parallel planar walls, at least one of which is transparent. | 2011-12-01 |
20110294201 | Test device for liquids of the human or animal body - A test device for liquids of the human or animal body, comprises a tube-shaped housing, in which are disposed:
| 2011-12-01 |
20110294202 | BIOREACTORS WITH MULTIPLE CHAMBERS - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber. | 2011-12-01 |
20110294203 | CELL WASHING - A cell cluster from which unwanted components are removed by efficiently washing the cell cluster is collected. Provided is a cell washing method including a centrifuging step (S | 2011-12-01 |
20110294204 | EXPRESSION SYSTEM - The present invention relates generally to methods and compositions for expression of polypeptides or delivery of interfering RNAs in various cell types. | 2011-12-01 |
20110294205 | AUTOMATED CELLULAR MATERIAL PREPARATION - Provided are cartridges and systems for effecting automated extraction, isolation, and purification of cellular components—such as nucleic acids—from a cellular sample in assay-ready form. Also provided are related methods of effecting such sample processing. | 2011-12-01 |
20110294206 | METHODS AND DESIGN OF MEMBRANE FILTERS - The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, drive pressure and filtration time. | 2011-12-01 |
20110294207 | SPATIALLY-DEFINED MODIFICATION OF FRESH TISSUE USING COVALENT CHEMISTRY - Methods for modification of tissue using covalent chemistry. Tissue can be modified through direct alkylation, reduction followed by alkylation, or oxidation followed by condensation to covalently attach small organic molecules or appropriately modified proteins. The modification can be spatially limited to desired regions of the tissue surface. | 2011-12-01 |
20110294208 | METHOD AND DEVICE FOR CELL SELECTION AND COLLECTION IN AN ISOLATED CULTURING ENVIRONMENT - An apparatus for collecting or culturing cells or cell colonies has a common substrate and a plurality of cell carriers releasably connected to the common substrate. The carriers are arranged in the form of an array. The invention employs microcups as the cell carriers. The substrate is preferably free of barriers between the microcups, and in some embodiments the microcups have porous walls. Methods of using the apparatus are also described. | 2011-12-01 |
20110294209 | METHODS FOR PRODUCING NONADHERENT AVIAN CELL LINES - The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells derived from such lines which are particularly useful for the production of substances of interest. | 2011-12-01 |
20110294210 | Microcarriers for Stem Cell Culture - We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50 μm and 400 μm, such as about 200 μm. It may have a cross sectional dimension of between 20 μm and 30 μm. The particle may comprise a substantially compact or spherical shaped particle having a size of between about 20 μm and about 120 μm, for example about 65 μm. We also disclose a method of propagating primate or human stem cells, the method comprising: providing first and second primate or human stem cells attached to first and second respective particles, allowing the first primate or human stem cell to contact the second primate or human stem cell to form an aggregate of cells and culturing the aggregate to propagate the primate or human stem cells for at least one passage. A method of propagating human embryonic stem cells (hESCs) in long term suspension culture using microcarriers coated in Matrigel or hyaluronic acid is also disclosed. We also disclose a method for differentiating stem cells. | 2011-12-01 |
20110294211 | HEPATOCYTE LINEAGE CELLS - Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver precursor cells or hepatocyte cells. | 2011-12-01 |
20110294212 | Methods of Screening Molecular Libraries and Active Molecules Identified Thereby - The present invention provides a peptide having 2 to 10 amino acids or a derivative thereof which is able to restore wild type function of human p53, for use in therapy; and a method of screening a library of molecules for the ability of members of that library to restore or modify the function of a target protein in an intra-cellular environment, which method comprises introducing the library into host cells which have a reporter system which allows the identification of those cells in which the function of the target protein has been restored or modified. | 2011-12-01 |
20110294213 | 2'-ARABINO-FLUOROOLIGONUCLEOTIDE N3'-P5' PHOSPHORAMIDATES: THEIR SYNTHESIS AND USE - Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-aribino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable. | 2011-12-01 |
20110294214 | Seeding Cells on Porous Supports - The present invention generally relates to a method for seeding cells on to a support. In particular, the method relates to a method for seeding cells onto a porous hydrophobic support. The method utilizes centrifugal forces to uniformly guide cell seeding into the support with no loss in viability. | 2011-12-01 |
20110294215 | CULTURE SYSTEMS - A microplate is provided herein having a plate body with at least one well formed therein, the well having a first open end, a second end, an aperture being formed in the second end, and a side wall extending between the first end and the second end. The microplate further has a permeable membrane extending at least partially across the aperture formed in the second end. A microplate is provided with a permeable membrane which allows not only for removal of certain solutes from a solution (high or low molecular weight solutes), but also allows for separation of macromolecular mixtures and degradation of the membrane. The microplate is also provided with an integrated top assembly or integrated inserts. Also provided herein are methods of culturing systems in the microplates described. | 2011-12-01 |
20110294216 | SULFONYLUREA-RESPONSIVE REPRESSOR PROTEINS - Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell. | 2011-12-01 |
20110294217 | DNA NICKING ENZYME FROM A HOMING ENDONUCLEASE THAT STIMULATES SITE-SPECIFIC GENE CONVERSION - An engineered highly specific DNA-cleavage enzyme delivers a site-specific nick in a double stranded DNA, to cleave one DNA strand within its target site while leaving the opposing DNA strand intact. The engineered enzyme provides the ability to induce a gene conversion event in a mammalian cell. An engineered sequence-specific nickase derived from a LAGLIDADG homing endonuclease is altered by a single amino acid residue, wherein the amino acid residue is involved in the polarization of solvent molecules and acid-base catalysis in the active site without affecting direct contacts between the enzyme and either the bound DNA or bound metal ions. Engineered, site-specific nickase variants, such as of I-AniI and other homing endonucleases, are particularly useful in targeted genome engineering as well as therapeutic, targeted gene repair. | 2011-12-01 |
20110294218 | CD34-DERIVED RECOMBINANT ADENO-ASSOCIATED VECTORS FOR STEM CELL TRANSDUCTION AND SYSTEMIC THERAPEUTIC GENE TRANSFER - Novel adeno-associated virus (AAV) isolates in nucleotide and amino acid forms and uses thereof are provided. The isolates show tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Discrete modified portions of the cap gene, VP1, VP2, and VP3, may be used alone or in combination in the present methods. | 2011-12-01 |
20110294219 | USE OF THE FOAMY VIRUS BET PROTEIN FOR INACTIVATING APOBEC - Described is the foamy virus Bet-mediated inactivation of the mutagenic, genome-modifying and vector-inactivating cellular enzyme ABOBEC. Such inactivation is useful for the treatment or prevention of various diseases, e.g., cancer, or for enhancing the production and genetic stability of gene therapy vectors, preferably retroviral vectors. | 2011-12-01 |
20110294220 | METHODS AND MATERIALS FOR THE DETECTION OF MELAMINE - Methods and materials for the detection of melamine in test samples such as foodstuffs are described. Embodiments of the invention comprise combining a test sample suspected of containing melamine with a particle that produces a colorimetric and/or turbidimetric signal that is dependent upon the concentration of melamine in the test sample. In certain embodiments of the invention, the particles and test sample are combined together with a chemical compound selected to induce the aggregation melamine in a manner that amplifies the colorimetric and/or turbidimetric signal of the assay. In some embodiments of the invention, the aggregation inducing agent is not physically coupled to the particles used in the assays. In other embodiments of the invention, the aggregation inducing agent is physically coupled to the particles used in these assays. | 2011-12-01 |
20110294221 | CONTROL BRACKETING AND RESULTS HOLD - An automated immunoassay analyzer, or assay system, provides for frequent testing of control samples to verify that before and after a series of tests of patients' samples, the operation of the test equipment is accurate, thereby ensuring that the results of the series of patient tests are accurate. Operating the immunoassay analyzer in this manner will delay reporting clinical test results until the results are confirmed as accurate. This operation can be performed automatically by a random access immunoassay analyzer. | 2011-12-01 |
20110294222 | LEAD ASSAY - Process for metering lead in a sample of original water, in which is placed a sample of the water of which at least a substantial portion of the colloidal and organic material is passed in solution (sample of pretreated water), having: a first stage, starting from a sample of pretreated water with an adjusted pH, the lead is concentrated and the other parasitic ions are at least partially eliminated to obtain a sample of water that is concentrated with lead and substantially lacking in other parasitic ions (sample of lead-concentrated water); and a second stage in which, starting from the sample of lead-concentrated water, the sample of lead-concentrated water is mixed with a selective, lead-sensitive fluorescent probe whose fluorescence intensity/lead metering function is known; then, the thus produced water/fluorescent probe mixture is excited by the light, and the fluorescence intensity of the thus excited water/fluorescent probe mixture is collected optically; finally, starting from the thus detected fluorescence intensity, the lead metering of the sample to be metered is determined based on the fluorescence intensity/lead metering function. | 2011-12-01 |
20110294223 | APPARATUS AND METHOD FOR CHARACTERIZING PARAMETERS FOR THE CRACKING, IN-SITU COMBUSTION, AND UPGRADING OF HYDROCARBONS - An apparatus for characterizing parameters for the cracking, in-situ combustion, and upgrading of hydrocarbons includes a reactor defining a chamber, a temperature probe operably associated with the reactor, and a gas inlet in fluid communication with the chamber. The apparatus further comprises a gas outlet in fluid communication with the chamber and an electromagnetic radiation attenuating material configured to heat the reactor when the electromagnetic radiation attenuating material is irradiated by electromagnetic radiation. | 2011-12-01 |
20110294224 | Devices, Systems, and Methods for Separating an Analyte From a Mixture, and Devices, Systems, and Methods for Measuring an Amount of an Analyte - Devices, systems, and methods for separating an analyte from a mixture, and devices, systems, and methods for measuring an amount of an analyte are disclosed. The devices, systems, and methods may be used to separate glycated hemoglobin from other blood components and to measure the amount of the glycated hemoglobin. | 2011-12-01 |
20110294225 | Method for Detecting Optical Signals, Microfluidic Mixing Chip Having Light Emitting Compound and System Thereof - A method for detecting optical signals, a microfluidic mixing chip having light emitting compound and a system thereof are provided. The microfluidic mixing system comprises the microfluidic mixing chip, an electrode pairs and a power supplier. The microfluidic mixing chip comprises a first side cavity, a second side cavity and a mixing cavity. The mixing cavity is disposed between the first side cavity and the second side cavity. The mixing cavity further contains the light emitting compound, a catalyst and a redox reagent. The electrode pair is respectively disposed to the first side cavity and the second cavity. The power supplier supplies a power source with high frequency alternating current electric field. By utilizing the power source with alternating current electric field, the light emitting compound, the redox reagent and the catalyst are mixed in the mixing cavity to generate a chemiluminescence or bioluminescence optical signal to detect. | 2011-12-01 |
20110294226 | Survival motor Neurons (SMN) gene: a gene for spinal muscular atrophy - The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding the SMN protein or a DNA sequence corresponding to the gene and transformant strains containing the SMN gene or a DNA sequence corresponding to the gene. | 2011-12-01 |
20110294227 | METHOD FOR DETERMINING THE RISK OF PREECLAMPSIA USING PIGF-2 AND PIGF-3 MARKERS - The present invention relates to a method for determining the risk of a pregnant woman developing pre-eclampsia. The method comprises i) determining the level of one or more biochemical markers in a sample obtained from a pregnant woman, and ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample. A difference in the level of the biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia. The isoform biochemical markers are preferably P1GF-2 and P1GF-3. The present invention relates also to a method for determining whether a pregnant woman has pre-eclampsia and as well as a kit for assessing the risk or presence of pre-eclampsia. In addition, the invention relates also to a computer program used in these determinations. | 2011-12-01 |
20110294228 | DETECTION DEVICES AND METHODS - The present invention relates to devices and methods for rapid and easy to use quantitative detection of one or more analytes in, for example, food, food ingredients, drinking water or pharmaceuticals. Analytes that can be detected by the devices and methods herein include, for example, adulterants, toxins, allergens, pathogens, pesticides, pharmaceuticals, pharmaceutical intermediates, biopolymers and biotechnology products. | 2011-12-01 |
20110294229 | COLORIMETRIC AND FLUORIMETRIC FLUORIDE SENSING - The present invention generally relates to fluoride receptor reagent compounds comprising one or more N-aryl or heteroaryl substituted 1,4,5,8-naphthalenetetracarboxydiimide (NDI) units and an associated method for the detection of fluoride in a composition. π-electron orbitals present in the NDI unit of the reagents form a complex with fluoride anions. It is believed that the anion-π interaction results in a charge transfer process between the fluoride anion and the NDI unit, resulting in a number of measurable effects (e.g., colorimetric response). | 2011-12-01 |
20110294230 | Lyophilization of Colloidal Metals for Surface Enhanced Raman Scattering - An assay and method of making same for use in SERS spectroscopy. The assay includes colloidal particles of a metal, which have been lyophilized. The lyophilized particles of metal produce a SERS active solution when reconstituted. The lyophilized particles of metal may be provided in a container in an assay system. | 2011-12-01 |
20110294231 | METHOD FOR REPAIRING COPPER DIFFUSION BARRIER LAYERS ON A SEMICONDUCTOR SOLID SUBSTRATE AND REPAIR KIT FOR IMPLEMENTING THIS METHOD - Method for repairing copper diffusion barrier layers on a semiconductor solid substrate and repair kit for implementing this method. | 2011-12-01 |
20110294232 | METHOD FOR RECOVERING DAMAGE OF LOW DIELECTRIC INSULATING FILM AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - There is provided a damage recovery method capable of recovering electrical characteristics of a low dielectric insulating film sufficiently while suppressing oxidation of buried metal and generation of pattern defaults. | 2011-12-01 |
20110294233 | METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE - Provided is a method of manufacturing a semiconductor device, which includes the steps of: (a) preparing a processing target including a wafer ( | 2011-12-01 |
20110294234 | THIN FILM SOLAR FABRICATION PROCESS, ETCHING METHOD, DEVICE FOR ETCHING, AND THIN FILM SOLAR DEVICE - Methods and devices for etching a device precursor are provided. For example, a method includes: providing a substrate, determining a temperature associated with the substrate, and etching a metal oxide layer of the substrate, wherein the etching is controlled based on the determined temperature. | 2011-12-01 |
20110294235 | METHOD OF FORMING A SEMICONDUCTOR DEVICE - A method of forming a semiconductor device includes the following processes. A groove is formed in a semiconductor substrate. A first film is formed in a device-formation region and a non-device-formation region of a semiconductor substrate. The first film is patterned to form a second film in the device-formation region and a monitoring pattern in the non-device-formation region. First and second structures are formed over the second film and the monitoring pattern respectively. The first structure has substantially the same pattern defined in a horizontal direction as the second structure. The first and second structures are polished. | 2011-12-01 |
20110294236 | Semiconductor device and method of manufacturing it - A method of manufacturing a semiconductor device capable of largely increasing the yield and a semiconductor device manufactured by using the method is provided. After a semiconductor layer is formed on a substrate, as one group, a plurality of functional portions with at least one parameter value different from each other is formed in the semiconductor layer for every unit chip area. Then, a subject that is changed depending on the parameter value is measured and evaluated and after that, the substrate is divided for every chip area so that a functional portion corresponding with a given criterion as a result of the evaluation is not broken. Thereby, at least one functional portion corresponding with a given criterion can be formed by every chip area by appropriately adjusting each parameter value. | 2011-12-01 |
20110294237 | PACKAGING METHOD OF SEMICONDUCTOR DEVICE - In a packaging method of semiconductor device, firstly, a wafer including a number of dies is provided. The wafer has an active surface and a back surface. The active surface adheres to a carrier. Subsequently, a number of openings are formed in each of the dies. Then, an insulating layer is formed on the back surface and on the side walls of the openings. A metal layer is formed to cover the insulating layer and the bottoms of the openings. A pattern protective layer is formed to cover the metal layer and to expose the metal layer outside the openings. Afterwards, the carrier is removed and the wafer is sawed. Later, a transparent substrate having a number of package units is provided. A spacer is formed at peripheral of each of the package units. A number of good dies are choose from the dies and disposed on the spacer. | 2011-12-01 |
20110294238 | SEMICONDUCTOR WAFER WITH ELECTRICALLY CONNECTED CONTACT AND TEST AREAS - The invention relates to an arrangement of contact areas and test areas on patterned semiconductor chips. The contact areas and the test areas are electrically connected to one another via a conduction web. Whereas the contact areas are arranged in a first region, which has no components of an integrated circuit, the test areas lie in a second region of the top side of the semiconductor chip, which region has components of an integrated circuit. | 2011-12-01 |
20110294239 | SUB-RESOLUTION ASSIST FEATURE ARRANGING METHOD AND COMPUTER PROGRAM PRODUCT AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE - According to a sub-resolution assist feature arranging method in embodiments, it is selected which of a rule base and a model base is set for which pattern region on pattern data corresponding to a main pattern as a type of the method of arranging the sub-resolution assist feature for improving resolution of the main pattern formed on a substrate. Then, the sub-resolution assist feature by the rule base is arranged in a pattern region set as the rule base and the sub-resolution assist feature by the model base is arranged in a pattern region set as the model base. | 2011-12-01 |
20110294240 | LIGHT-EMITTING DEVICE, LIGHT-EMITTING SYSTEM INCLUDING THE SAME, AND FABRICATING METHOD THEREOF - A light-emitting device having improved light conversion efficiency, a light-emitting system including the same, and fabricating methods of the light-emitting device and the light-emitting system, are provided. The light-emitting device includes one or more light-emitting elements arranged on one surface of a substrate, and a phosphor layer disposed inside or on the substrate to a predetermined thickness and partially wavelength-converts the light emitted from the one or more light-emitting elements into light having different wavelength, wherein a light conversion efficiency of the phosphor layer is maximized when the phosphor layer has the predetermined thickness. | 2011-12-01 |
20110294241 | Method of using white resin in an electronic device - The coating agent of the invention is a coating agent to be used between conductor members, comprising a thermosetting resin, a white pigment, a curing agent and a curing catalyst, the coating agent to be used between conductor members having a white pigment content of 10-85 vol % based on the total solid volume of the coating agent, and a whiteness of at least 75 when the cured product of the coating agent has been allowed to stand at 200° C. for 24 hours. | 2011-12-01 |