48th week of 2012 patent applcation highlights part 50 |
Patent application number | Title | Published |
20120302415 | KNIFE FOLDING MACHINE - A knife folding machine comprises: a support surface ( | 2012-11-29 |
20120302416 | METHOD OF FORMING A ROD FOR USE IN THE MANUFACTURE OF CIGARETTE FILTERS - An apparatus and associated method is provided for forming a rod for use in the manufacture of cigarette filter elements. A continuous supply of a filter material is formed into a continuous filter rod by a rod-forming unit. An object insertion unit is configured to insert a plurality of first objects and a plurality of second objects into the continuous filter rod. A rod-dividing unit is configured to subdivide the continuous filter rod, at predetermined intervals along the longitudinal axis thereof, into a plurality of filter rod portions such that each filter rod portion includes at least one first object and at least one second object disposed therein, with the first objects being different from the second objects. | 2012-11-29 |
20120302417 | MANUFACTURING METHOD OF ABSORBENT ARTICLE - A method of manufacturing an underpants-type absorbent article having an outer body provided with a mutually separate front piece, back piece and connecting sheet, and wherein the front piece and the back piece are mutually joined at side areas and are mutually connected by the connecting sheet extending in the front-to-rear direction at the crotch area, and an inner body containing an absorptive body and which is overlapped and anchored to the connecting sheet on the inside of the outer body, comprises, in turn, transporting a continuous body of the front piece in the form of a front piece web and a continuous body of the back piece in the form of a back piece web in a machine direction while maintaining a spacing area in a cross-machine direction, forming a continuous body of the outer body in the form of an outer body web by attaching the connecting sheet to the front piece web and the back piece web at intervals in the machine direction so as to straddle the spacing area, cutting the outer body web in order to form edges that define leg holes, and attaching the inner body to the outer body web. | 2012-11-29 |
20120302418 | System For Bifolding An Absorbent Article - A system is provided for bifolding disposable absorbent articles on a high speed production line on which the disposable absorbent articles are moved along a predetermined path. The system includes the use of one or more vacuum conveyor assemblies to engage and transfer the leading end portion of the article from the surface of a peel-roll to a folding drum. Thereby potentially reducing the occurrence of undesirable misalignment between opposing edges of an article during a bifolding process. | 2012-11-29 |
20120302419 | AUTOMATIC BALANCE ADJUSTING CENTRIFUGE AND THE CONTROL METHOD THEREOF - The present invention relates to an automatic balance adjusting centrifuge which calculates the magnitude and the location of imbalance of itself based on the vibration generated in the dynamic state and automatically compensate for the imbalance based on the calculation, and the control method thereof. The method includes: (a) measuring the amount of vibration of a rotor of a centrifuge, supporting buckets that load samples, at a predetermined rotational velocity; (b) determining whether the amount of vibration measured in step (a) is greater than an allowed value; and (c) when the amplitude of the vibration is greater than the allowed value, compensating for a weight imbalance of the rotor by an amount calculated based on the vibration amount measured in step (a) and returning to step (a), otherwise, performing a centrifugal separation by accelerating the rotor to a working velocity. | 2012-11-29 |
20120302420 | CENTRIFUGAL DROPLET SEPARATOR FOR SEPARATING LIQUID DROPLETS OUT OF A FEED GAS STREAM COMPRISING THEM - What is proposed is a centrifugal droplet separator for separating liquid droplets out of a feed gas stream comprising them, with a vertical longitudinal axis and circular cross section, with a jacket ( | 2012-11-29 |
20120302421 | CERAMIC COMPOSITIONS FOR INCREASED BATCH FEED RATE - A precursor batch composition that can be used to make porous ceramic articles is provided. The batch composition includes a cellulose-based polymer and, in particular, a methylcellulose showing a specified micro-calorimetry thermal response fingerprint. The methylcellulose can also have a cloud point above a specified temperature. | 2012-11-29 |
20120302422 | Lithium-Aluminosilicate Glass With Short Glazing Times - A lithium-aluminosilicate glass or a corresponding glass ceramic that has a content of 0-0.4SnO | 2012-11-29 |
20120302423 | Glass for Light Guide Fiber - A glass for a light guide fiber GA1 is used in a core of a fiber | 2012-11-29 |
20120302424 | OPTICAL GLASS, GLASS MOLDED BODY, OPTICAL DEVICE AND THEIR PRODUCTION METHODS - An optical glass comprising, by mass %, 12 to 30% of total of B | 2012-11-29 |
20120302425 | CUBIC BORON NITRIDE SINTERED BODY TOOL - The cubic boron nitride sintered body tool of the present invention has a cubic boron nitride sintered body including cubic boron nitride particles and a binder phase at at least a cutting edge. The cubic boron nitride sintered body includes 40-70 volume % of cubic boron nitride particles. The binder phase includes a first component and a second component. The first component includes TiC, and the second component includes one or both of TiB | 2012-11-29 |
20120302426 | CERAMIC COMPOSITIONS FOR REDUCED PLUG RATE - A precursor batch composition that can be used to make porous ceramic articles is provided. The batch composition includes a cellulose-based polymer and, in particular, a methylcellulose having a number average molecular weight (M | 2012-11-29 |
20120302427 | POLYMERIC STRUCTURES FOR ADSORBING BIOLOGICAL MATERIAL AND THEIR METHOD OF PREPARATION - A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm-50 μm and height greater than 1 μm. | 2012-11-29 |
20120302428 | CONTROLLED POROUS CATALYSTS TO PRODUCE HYDROGEN GAS BY DEHYDROGENATING ORGANIC COMPOUNDS - The current application discloses a method for producing a porous catalyst, the method comprising providing a powder of metal particles with a specific size; mixing into the powder of metal particles spacer spheres with a fixed diameter less than that of the metal particles; placing the metal-particle/spacing-sphere mixture in a ceramic container; heating the mixture in an oven, furnace or microwave oven to sinter the metal particles and fuse them to a solid matrix; and removing the spacing spheres either by solvolysis or pyrolysis. | 2012-11-29 |
20120302429 | METHOD FOR PRODUCING DISPERSION OF NOBLE METAL-SUPPORTED PHOTOCATALYST PARTICLES, DISPERSION OF NOBLE METAL-SUPPORTED PHOTOCATALYST PARTICLES, HYDROPHILIZING AGENT AND PHOTOCATALYTIC FUNCTIONAL PRODUCT - Dispersion of noble metal-supported photocatalyst particles, which exhibits high photocatalytic activity, and also has stable dispersibility that enables prevention of precipitation of photocatalyst particles in a dispersion medium; a method for producing the same; a hydrophilizing agent; and a photocatalytic functional product. | 2012-11-29 |
20120302430 | METHOD OF PRODUCING NOBLE METAL-SUPPORTED POWDER, NOBLE METAL-SUPPORTED POWDER AND EXHAUST GAS PURIFYING CATALYST - In the present invention, slurry is formed by mixing noble metal-supported powder particles ( | 2012-11-29 |
20120302431 | COMPOSITE CATALYST AND METHOD FOR PREPARATION THEREOF - A composite catalyst, including: a) dispersed and cationic surface modifier-modified attapulgite as a catalyst carrier; and b) nano-Au as an active ingredient. The nano-Au accounts for 0.5-1.5 wt. % of the attapulgite. An average diameter of the attapulgite is 18-22 nm, and a length thereof is 100-1000 nm. A particle diameter of the nano-Au is 1-7 nm. The composite catalyst has a low activation temperature and high performance-to-price ratio, and can be used for oxidation of organic pollutants in waste gas under low temperatures and also has excellent catalytic effects on organic pollutants in waste fluid. A preparation method of the composite catalyst is also provided. | 2012-11-29 |
20120302432 | Sulfur-Resistant Exhaust Gas Aftertreatment System For The Reduction Of Nitrogen Oxides - An arrangement for aftertreatment of exhaust gas for lean-burn internal combustion engines such as diesel engines and Otto engines with direct injection has a NO | 2012-11-29 |
20120302433 | Catalytic Reactor Treatment Process - An activation process for a Fischer-Tropsch catalyst is described. The process comprises a first reduction step; an oxidation step; the introduction of the catalyst into a Fischer-Tropsch reactor; and a second reduction step. | 2012-11-29 |
20120302434 | SIX-MEMBERED N-HETEROCYCLIC CARBENE-BASED CATALYSTS FOR ASYMMETRIC REACTIONS - The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided. | 2012-11-29 |
20120302435 | Process and Catalyst for Production of Mixed Alcohols from Synthesis Gas - A preferred embodiment of the process involves a generate a catalyst that comprises molybdenum carbide nickel material. Steps may involve heating a surface that comprises molybdenum oxide and a nickel salt while passing thereover a gaseous mixture that comprises a reductant and a carburizer. In certain embodiments, the reductant and the carburizer may both be carbon monoxide, or both be a saturated hydrocarbon. In others, the reductant may be carbon monoxide and the carburizer may be a saturated hydrocarbon. | 2012-11-29 |
20120302436 | GRANULES COMPRISING SILICA AND TITANIA - A granulated material comprising a mixed silicon-titanium oxide powder, wherein a proportion of TiO | 2012-11-29 |
20120302437 | Nanocrystal Assembly for Tandem Catalysis - The present invention provides a nanocrystal tandem catalyst comprising at least two metal-metal oxide interfaces for the catalysis of sequential reactions. One embodiment utilizes a nanocrystal bilayer structure formed by assembling sub- | 2012-11-29 |
20120302438 | COMPLEX OXIDE, METHOD FOR PRODUCING SAME AND EXHAUST GAS PURIFYING CATALYST - Disclosed are a composite oxide which is capable of maintaining a large specific surface area even used in a high temperature environment, and which has excellent heat resistance and reducibility, as well as a method for producing the composite oxide and a catalyst for exhaust gas purification employing the composite oxide. The composite oxide contains cerium and at least one of rare earth metal elements other than cerium and including yttrium, at amass ratio of 85:15 to 99:1 in terms oxides, and further containing silicon at more than 0 parts by mass and not more than 20 parts by mass in terms of SiO | 2012-11-29 |
20120302439 | ENGINE EXHAUST CATALYSTS DOPED WITH BISMUTH OR MANGANESE - An emission control catalyst is doped with bismuth, manganese, or bismuth and manganese. The doped catalyst may be a palladium-gold catalyst or a platinum-based catalyst, or both. The doped palladium-gold catalyst and the doped platinum-based catalyst may be contained in a single washcoat layer or in different washcoat layers of a multi-brick, multi-zoned, or multi-layered emission control system. In all embodiments, zeolite may be added as a hydrocarbon absorbing component. | 2012-11-29 |
20120302440 | ABSORBENT ARTICLE COMPRISING A COMPOSITE MATERIAL - An absorbent article including a freeze dried composite material. The freeze dried composite material includes cellulosic pulp (e.g. CTMP) and an absorbent material. The absorbent material includes microfibrillated cellulose (MFC) with a specified content of carboxylate groups. | 2012-11-29 |
20120302441 | HERBICIDAL MIXTURES - A synergistic herbicidal mixture comprising
| 2012-11-29 |
20120302442 | PLANT SUPPORT FORMULATION, VEHICLE FOR THE DELIVERY AND TRANSLOCATION OF PHYTOLOGICALLY BENEFICIAL SUBSTANCES AND COMPOSITIONS CONTAINING SAME - A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer. The dispersion is further also characterized in that the micro-emulsion has a zeta potential of between −25 mV and −60 mV. | 2012-11-29 |
20120302443 | NOVEL GLYPHOSATE FORMULATION - The present invention provides a solid glyphosate formulation comprising glyphosate acid and further comprising at least one agriculturally acceptable salt of glyphosate, wherein the glyphosate acid and the at least one glyphosate salt are in admixture and wherein the mole ratio of glyphosate acid to total glyphosate moieties in the formulation is at least 10%. Methods of preparing said formulations are also provided. The present invention further provides a method of removing unwanted foliage comprising administering a diluted form of a formulation according to the present invention. | 2012-11-29 |
20120302444 | LIQUID SUSPENSION CONCENTRATE FORMULATIONS CONTAINING SAFLUFENACIL - The present invention relates to liquid suspension concentrate formulations for plant protection comprising: 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide in the form of the crystalline anhydrate; at least one diluent selected from: hydrocarbon solvents having a boiling point of at least 100° C.; and C | 2012-11-29 |
20120302445 | PROCESS FOR RECYCLING POLYMER FINES - The present invention relates to a process for producing a water-absorbing polymer structure based on acid group-containing monomers, comprising the process steps of:
| 2012-11-29 |
20120302446 | JOSEPHSON MAGNETIC SWITCH - New type of Josephson switch based on Josephson superconductor/insulator/ferromagnet/superconductor (SIFS) junction is disclosed. This Josephson SIFS junction has a ferromagnetic (F-) barrier whose magnetization can be controlled by magnetic field pulses. The critical current of such SIFS junction can be controlled using the remanent magnetization of the junction ferromagnetic (F-) barrier. The proposed switch exploits a weakly ferromagnetic (F-) thin-film inner layer with in-plane magnetic anisotropy and small coercive field (for example, Pd | 2012-11-29 |
20120302447 | MOCK COMMUNITY FOR MEASURING PYROSEQUENCING ACCURACY AND METHOD OF MEASURING PYROSEQUENCING ACCURACY USING THE SAME - The present invention describes a method of measurement of pyrosequencing accuracy by directly calculating sequence errors from FLX Titanium pyrosequencing using mock community, according to the present invention, sequencing errors from FLX Titanium pyrosequencing in terms of microbial diversity and classification can be measured, resulting in possible effects of filtering. | 2012-11-29 |
20120302448 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided. | 2012-11-29 |
20120302449 | Chromosome Conformation Analysis - Disclosed herein are compositions, methods and kits for analyzing three-dimensional chromatin and/or chromosome conformation. Method are also disclosed for using the methods disclosed herein for diagnosing diseases such as cancer. | 2012-11-29 |
20120302450 | Bacterial Metastructure and Methods of Use - The present invention provides a method of determining bacterial metastructure by integrating multiple genome-scale information yielded by high-throughput technologies. The metastructure constructs a universal metabolic engineering platform enabling a rational design of bacterial strains through optimization of gene and protein expression. | 2012-11-29 |
20120302451 | COMPOSITIONS AND METHODS FOR GENE SIGNATURE-BASED CHEMICAL SCREENING - The invention provides products of manufacture for screening for compositions that can modify a cell's gene expression profile, and methods for making and using them. In one embodiment, the invention provides products of manufacture and methods comprising a high content, high throughput screening for a composition (e.g., chemicals, small molecules) that can modify a cell's physiology based on the composition's ability to modify the cell's gene expression signature. | 2012-11-29 |
20120302452 | COMPARATIVE LIGAND MAPPING FROM MHC CLASS I POSITIVE CELLS - The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be uninfected, infected, or tumorgenic. The methodology of the present invention broadly allows for these peptide ligands and their comcomittant source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorgenic versus nontumorgenic cells with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected cells. | 2012-11-29 |
20120302453 | OXOCARBONAMIDE PEPTIDE NUCLEIC ACIDS AND METHODS OF USING SAME - The present invention concerns oxocarbonamide peptide nucleic acids (OxoPNAs). OxoPNAs provide increased stability, sensitivity, and specificity as compared to their natural DNA and RNA counterparts. The OxoPNA molecules of the present invention may be employed in a wide range of applications, particularly in applications involving hybridization. For example, OxoPNA probes may be employed for the detection and functional analysis of nucleic acid molecules, including miRNAs and other non-coding RNAs. | 2012-11-29 |
20120302454 | NANO-SENSOR ARRAY - In one embodiment, a method is provided for the manufacture of a nano-sensor array. A base having a sensing region is provided along with a plurality of nano-sensors. Each of the plurality of nano-sensors is formed by: forming a first nanoneedle along a surface of the base, forming a dielectric on the first nanoneedle, and forming a second nanoneedle on the dielectric layer. The first nanoneedle of each sensor has a first end adjacent to the sensing region of the base. The second nanoneedle is separated from the first nanoneedle by the dielectric and has a first end adjacent the first end of the first nanoneedle. The base is provided with a fluidic channel. The plurality of nano-sensors and the fluidic channel are configured and arranged with the first ends proximate the fluidic channel to facilitate sensing of targeted matter in the fluidic channel. | 2012-11-29 |
20120302455 | METHODS OF IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF LUNG DISEASES AND KITS THEREOF - The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subjects response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided. | 2012-11-29 |
20120302456 | VERTICAL FLOW-THROUGH DEVICES FOR MULTIPLEXED ELISA DRIVEN BY WICKING - The invention provides kits, methods and devices for detection of analytes in a biological sample. Capillary action is employed to carry out single or multiplexed immunoassays in a vertical flow-through format. | 2012-11-29 |
20120302457 | Population Scale HLA-Typing and Uses Therof - The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray. | 2012-11-29 |
20120302458 | CARDIOVASCULAR AUTOIMMUNE DISEASE PANEL AND METHODS OF USING SAME - Provided herein are diagnostic tests, methods of use, and kits for the assessment and management of cardiovascular autoimmune disease and risk of cardiovascular autoimmune disease. Assay methods of the invention can be employed to identify cardiovascular autoimmune disease, or risk thereof, in subjects who have cardiovascular disease, an autoimmune disease, or who are related to an individual with an autoimmune disease; for testing of a subject that exhibits symptoms of cardiovascular disease, as well as of a subject that is apparently healthy and does not yet exhibit symptoms of cardiovascular disease; and for determining whether a subject having, or at risk for, a cardiovascular disease is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components useful for performing the methods. | 2012-11-29 |
20120302459 | Articles Having Localized Molecules Disposed Thereon and Methods of Producing Same - Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate. | 2012-11-29 |
20120302460 | Use of Low Affinity Neurotrophin Receptor P75 As Marker for High Differentiation Potential Muscle Stem Cells, Muscle Satellite Cells, And Degenerative Skeletal Muscle Diseases - The marker for highly differentiating power muscle stem cells, muscle satellite cells and degenerative skeletal muscle diseases consists in the receptor recorded as PG8138, TNR16_HUMAN in the UniProtKB database, expressed in the skeletal muscle cells. The cellular expression of said receptor is also determined by the identification of highly differentiating power muscle stem cells and satellite cells. | 2012-11-29 |
20120302461 | GFP MUTAGENESIS AMPLIFICATION: USE OF A FLUORESCENCE-ANTIBIOTIC RESISTANCE FUSION DUAL REPORTER CONSTRUCT TO PROVIDE QUANTITATIVE AND HIGHLY SENSITIVE DETECTION OF MUTATIONS - A reversion mutation assay that is unique in providing a quantitative readout for mutagenesis. This assay is based on the creation of a functional GFP-β-lactamase fusion protein as a reporter providing both antibiotic resistance and fluorescence. This dual reporter is placed in a multicopy plasmid to increase the number of targets, with a reversion site at the N-terminus. Rare mutations at the reversion site allow read-through of the fusion protein, producing both beta-lactamase (providing antibiotic resistance) and GFP (emitting fluorescence). In the presence of carbenicillin, beta-lactamase production confers a selective advantage that allows amplification of mutant plasmids, raising the level of fluorescence emitted by GFP to levels that are detectable by fluorimetry. A window of time can be found where fluorescence is proportional to the number of mutation events at the reversion site, making fluorescence a quantitative measure of mutagenesis. Quantitative (as opposed to binary) detection of mutations allows substantial savings in test sample. This has applications in drug discovery, allowing high-throughput screening for DNA-targeting compounds and early pre-screening of leads for potential carcinogenic activity. The increased sensitivity of this assay also facilitates monitoring complex environmental samples. | 2012-11-29 |
20120302462 | System and Method for Detecting and Quantifying Active T-cells or Natural Killer Cells - A system and a methodology are provided with a broad range of application in immune diagnostic screening and therapy and specifically for predicting the risk of graft versus host disease (GVHD) and/or graft versus leukemia (GVL) effects prior to transplantation. The method includes the steps of incubating single T or NK cells with a few, usually three to five target cells for extended period of times and evaluating the cell contact-dependent lytic activity or activation of the single effector cells within larger populations. The results obtained are analyzed by proprietary software for automated image analysis and compared with patient data comprised in a comprehensive database containing accumulated empirical and clinical information on donor-recipient screening results and patient information. A micro device is provided for implementing the disclosed method, wherein said micro device is a multi-well microchip, having tens of thousands wells with defined characteristics thus allowing long-term assays and quantitative cell activity inspection/evaluation by high-resolution microscopy. | 2012-11-29 |
20120302463 | FOCUSED LIBRARIES OF GENETIC PACKAGES - Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies. | 2012-11-29 |
20120302464 | METHODS FOR PRODUCING RECOMBINANT PROTEINS - Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins. | 2012-11-29 |
20120302465 | POLYMERIC STRUCTURES FOR ADSORBING BIOLOGICAL MATERIAL AND THEIR METHOD OF PREPARATION - A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm-50 μm and height greater than 1 μm. | 2012-11-29 |
20120302466 | T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS - The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same. | 2012-11-29 |
20120302467 | Patterned substrates for cell applications - The present invention relates to a method for making arrays or patterns comprising hydrophilic areas and hydrophobic background surrounding the hydrophilic areas, methods of cultivating cells using these arrays or patterns, and uses of these arrays or patterns in cell cultivation methods, e.g. for cell patterning, cell screenings, cell transfection and cell co-culturing. | 2012-11-29 |
20120302468 | FORMULATIONS AND USES OF DRILLING FLUIDS CONTAINING VISCOSIFIED PHOSPHATE BRINE - Viscosified phosphate brine base fluids are disclosed, where the fluids include a hydratable polymer, have a density at or above about 10 lb/gal and a viscosity of at least 5 cP. Method for making and using the viscosified phosphate brine base fluids are also disclosed, including using the fluid in drilling, completing, and/or fracturing of oil and/or gas wells. | 2012-11-29 |
20120302469 | Carbon Dioxide Capture and Mitigation of Carbon Dioxide Emissions - The present invention describes methods and systems for extracting, capturing, reducing, storing, sequestering, or disposing of carbon dioxide (CO | 2012-11-29 |
20120302470 | COMPOSITIONS, METHODS, APPARATUS, AND SYSTEMS FOR INCORPORATING BIO-DERIVED MATERIALS IN DRILLING AND HYDRAULIC FRACTURING - The present invention provides compositions, methods, apparatus, and systems to minimize environmental impact, water use, and overall cost of drilling and hydraulic fracturing for crude oil and natural gas. Some variations of the invention provide a fracturing-fluid additive composition comprising a water-soluble portion of a biomass-pyrolysis liquid. In some embodiments, the fracturing-fluid additive composition is substantially biodegradable and is not toxic. Some variations provide improved proppants for oil or gas well fracturing. Other variations of this invention relate to drilling-fluid additive compositions, and methods of using these compositions. This invention can significantly improve the environmental, economic, and social sustainability associated with drilling and fracturing for production of oil and gas. | 2012-11-29 |
20120302471 | WATERBORNE POLYISOCYANATE COMPOSITION THAT PROVIDES A LOW FRICTION COATING - The present invention is a chemical composition that provides a low friction coating and a low sliding coefficient of friction onto a plastic or metal working part that includes a waterborne polyisocyanate such as ureas, urethanes or tetramethylxylene diisocyanates (TMXDI) in the composition structure and a plurality of cross linkable functional groups that include carboxyl groups and hydroxyl groups that are added utilizing plasma or chemical grafting and etching and a plastic or metal chemical substrate. The composition also includes one or more materials that are single linked or multiple linked hydrogels such as polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) or polyvinyl alcohol (PVA) mixed with the polyisocynate and one or more crosslinkers such as aziridines or carbodiimides that link the hydrogels, the polyisocynate and the substrate together to form the composition. | 2012-11-29 |
20120302472 | Lubricating Greases Containing Lignosulfonate, The Production Thereof, and the Uses Thereof - The object of the invention are lubricating greases that contain calcium lignin sulfonates, and which consist of a base oil, calcium soaps, calcium lignin sulfonate having average molecular weights (weight average) greater than 10,000 g/mol as well as other, optional alkaline earth lignin sulfonates, producible by heating to temperatures above 120° C. converting and driving out components with low boiling point in order to produce a base grease, and cooling and addition of base oil and possibly other additives with mixing, a corresponding process, and use of the lubricating greases containing calcium lignin sulfonate. | 2012-11-29 |
20120302473 | OIL-IN-OIL COMPOSITIONS AND METHODS OF MAKING - This invention is directed to a lubricant composition that is comprised of a continuous phase and a discontinuous phase, i.e., a two phase lubricant composition. The continuous phase and the discontinuous phase of the lubricant of this invention are oil or oil type compositions that are essentially insoluble in one another. The lubricant composition is comprised of a continuous phase base oil that is comprised of a low viscosity Group II, III, IV or GTL base stock or a blend of at least two of the Group II, III, IV and GTL base stocks, optionally including a low viscosity Group V base stock, with the continuous phase base oil having, independently, a viscosity of from 1 to 100 cSt at 100° C. The lubricant composition is further comprised of a discontinuous phase that is comprised of an ester composition having a mean average droplet size of from 0.01 microns to 20 microns, in which the ester composition is comprised of an ester compound having no ether linkages. | 2012-11-29 |
20120302474 | OIL SOLUBLE TAGGANTS - A process for detecting oil or lubricant contamination in the production of an article by adding a Stokes-shifting taggant to an oil or lubricant of a machine utilized to produce the article or a component thereof, irradiating the articles produced with a first wavelength of radiation, and monitoring the articles for emission of radiation at a second wavelength. The taggant can be in the form of a composition containing a Stokes-shifting taggant, which absorbs radiation at a first wavelength and emits radiation at a second wavelength, different from said first wavelength, dissolved or dispersed in an oil or lubricant. | 2012-11-29 |
20120302475 | ADDITIVE COMPOSITION FOR LUBRICATING OIL - An additive composition is provided for a lubricating oil that is easy to produce, does not have adverse effects, such as causing rubber seals to swell, and is excellent in storage stability. The additive composition contains a metal salt of a phosphorus-containing compound represented by formula (1) in an amount of 10 to 90 percent by mass of the composition, contained in a hydrocarbon solvent selected from a mineral oil, a hydrocarbon synthetic oil and a mixture thereof, the hydrocarbon solvent having a 100° C. kinematic viscosity of 0.5 to 4.5 mm | 2012-11-29 |
20120302476 | (METH)ACRYLATE POLYMERS FOR IMPROVING THE VISCOSITY INDEX - The invention relates to a (meth)acrylate polymer for improving the viscosity index, which comprises a) from 5 to 60 wt % of repeating units that are derived from (meth)acrylates of formula (I), where R represents hydrogen or methyl and R1 is an alkyl radical having from 1 to 6 carbon atoms, b) from 5 to 80 wt % of repeating units that are derived from (meth)acrylates of formula (II), where R is hydrogen or methyl and R2 is an alkyl radical having from 7 to 30 carbon atoms, and c) from 15 to 90 wt % of repeating units that are derived from (meth)acrylates of formula (III), where R is hydrogen or methyl, n is an integer in the range of 2 to 500 and A is C2-C4 alkylene and R3 is a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms. The invention further relates to novel lubricating oil compositions, to a method for producing the above-mentioned (meth)acrylate polymers and to the use thereof for improving the viscosity index of lubricating oil compositions that comprise at least one polar base oil. | 2012-11-29 |
20120302477 | POLYMER USEFUL AS VISCOSITY INDEX IMPROVER - The present invention describes a polymer useful as viscosity index improver comprising units derived from one or more ethylenically unsaturated ester compounds of formula (I), where R is hydrogen or methyl, R | 2012-11-29 |
20120302478 | METHOD FOR PRODUCING A TWO PHASE LUBRICANT COMPOSITION - This invention provides a method for producing a lubricant composition that is comprised of a continuous phase and a discontinuous phase. The method involves mixing together high viscosity ester, ether or combination thereof, and polar diluent or solvent, to produce a solution. The solution is then added to a low viscosity Group IV base oil to produce a discontinuous phase dispersed throughout a continuous phase. | 2012-11-29 |
20120302479 | Method of Lubricating a Manual Transmission - The present invention relates to a method of lubricating a driveline device comprising supplying to the driveline device a lubricating composition comprising an oil of lubricating viscosity and an aromatic hydroxy-substituted compound. The invention further provides for the use of the lubricating composition comprising the aromatic hydroxy-substituted compound as at least one of a filterability aid, and a wax crystal growth modifier/gelation inhibitor in the driveline device. | 2012-11-29 |
20120302480 | ADDITIVE CONCENTRATE - The present invention provides an additive concentrate comprising: − at least 90 wt. % of a Fischer-Tropsch derived base oil, based on the total weight of the additive concentrate; − at least 3.0 wt. % of a viscosity modifier, based on the total weight of the additive concentrate; and − less than 5.0 wt. % of a solvency booster, based on the total weight of the additive concentrate. | 2012-11-29 |
20120302481 | ALPHA-OLEFIN (CO)POLYMER, HYDROGENATED ALPHA-OLEFIN (CO)POLYMER AND LUBRICATING OIL COMPOSITION CONTAINING THE SAME - Provided are an α-olefin (co)polymer useful as high-viscosity lubricant oil excellent in viscosity characteristics and low-temperature characteristics, and a lubricant oil containing the (co)polymer. The α-olefin (co)polymer is produced by the use of a metallocene catalyst and satisfies the following (a′) and (b′). (a′) The 2,1-insertion ratio at the polymer terminal, as measured through | 2012-11-29 |
20120302482 | ALKALINE DETERGENT COMPOSITION FOR USE ON HARD SURFACES - An alkaline detergent composition for hard surface comprises an alkaline agent (component A), a nonionic surfactant (component B), a chelating agent (component C), water (component D), at least one carboxylic acid compound (component E) selected from the group consisting of compounds represented by general formula (1) and general formula (2), and at least one anionic surfactant (component F) selected from the group consisting of surfactants represented by general formula (3) and salts thereof. Therein, the content ratio [component E (weight %)/component B (weight %)] is 1/1.5-15/1, the content ratio [component F (weight %)/component B (weight %)] is 10/1-1/5, and the pH at 25° C. is 12 or greater. | 2012-11-29 |
20120302483 | PHOTORESIST REMOVAL - Disclosed herein is a composition and method for semiconductor processing. In one embodiment, a wet-cleaning composition for removal of photoresist is provided. The composition comprises a strong base; an oxidant; and a polar solvent. In another embodiment, a method for removing photoresist is provided. The method comprises the steps of applying a wet-cleaning composition comprising about 0.1 to about 30 weight percent strong base; about one to about 30 weight percent oxidant; about 20 to about 95 weight percent polar solvent; and removing the photoresist. | 2012-11-29 |
20120302484 | COMPOSITION FOR THE PREVENTION OR REMOVAL OF INSOLUBLE SALT DEPOSITS - The present invention provides compositions, in particular blocks, tablets and gels, for the prevention or removal of insoluble salt deposits comprising: a) an organic acid with two carboxylic acid functional groups obtainable by fermentation, selected from the list of itaconic acid, itaconic acid anhydride, succinic acid, succinic anhydride and combinations thereof, and b) at least one compound determining the release of said acid from said composition, said compound is selected from a list comprising: i) a hygroscopic compound, ii) a carbonate source, iii) an acid solubility retarding compound, iv) a compound with melting point situated between 60° C.-95° C., and combinations thereof. The invention further provides uses of the compositions for the prevention or removal of insoluble salt deposits. The invention also provides a method of manufacturing such compositions and a method for the prevention or removal of insoluble salt deposits with a product of the invention. | 2012-11-29 |
20120302485 | Method and Composition for Removing Stains - A method and composition for removing stubborn stains that includes the application of a mixture comprising alkyl dimethyl benzyl ammonium chlorides, bleach, and water. A major advantage of the method is that the composition solution is strong enough to remove stubborn stains from soft and hard surfaces and restore original appearance and scent to old fabrics, yet sufficiently mild to not damage delicate and colored fabrics or pose a threat to the person treating the stain. | 2012-11-29 |
20120302486 | Mixtures of Fibre-Reactive Dyes and Their Use in a Method for Di- or Trichromatic Dyeing or Printing - Dye mixtures, comprising at least one red dyeing dye of the formula (1) and at least one blue, yellow, orange or brown dyeing dye from the group of the formulae (2), (3), (4), (5) and (6), wherein B is an aliphatic bridging member, R | 2012-11-29 |
20120302487 | COMPOSITE - A composite includes: one or more core units comprising a bleach activating agent; and an alkali soluble polymer coating on the surface of said one or more core units. | 2012-11-29 |
20120302488 | FABRIC CARE COMPOSITIONS COMPRISING ORGANOSILOXANE POLYMERS - The present composition relates to fabric care compositions comprising an organosiloxane polymer. Methods of using such compositions including contacting a fabric with the composition and rinsing the fabric are also disclosed. | 2012-11-29 |
20120302489 | FUNCTIONALIZED POLYVINYL ALCOHOL FILMS - A film-forming composition includes a blend of polyvinyl alcohol and hydrophobically modified solution polymer or a water soluble polymer including an anionic ethylenically unsaturated monomer wherein the composition has a pH of about 5 or less. Further included are self-supporting materials, such as films, derived from the compositions and formulations including at least one volume-filling formulation surrounded by the self-supporting material. | 2012-11-29 |
20120302490 | Bleach Catalyst Compounds, Method For The Production Thereof And Use Thereof - The invention relates to compounds in solid form, containing a) one or more manganese complex compounds of the general formula (I), where M is independently selected from manganese in the III or IV oxidation state, X is independently a co-ordinating or bridging species selected from H | 2012-11-29 |
20120302491 | MODULATION OF ESTROGEN RECEPTOR-RELATED RECEPTOR GAMMA (ERR GAMMA) AND USES THEREFOR - This application provides methods of increasing vascularization, muscle performance, muscle rehabilitation, and/or mitochondrial activity in subjects in need thereof, by administering a therapeutically effective amount of one or more agents that increases ERRγ activity to the subject. Such agents can include one or more ERRγ agonists. In some examples the method does not require that the subject exercise, and as such, the subject may be sedentary (such as bedridden or in a wheelchair). | 2012-11-29 |
20120302492 | Antibody Mimetic Scaffolds - Provided herein are protein scaffolds, e.g. antibody mimetic scaffolds, comprising a three finger protein domain that specifically bind to target molecules, polynucleotides encoding such proteins, methods of using such proteins, and libraries of such scaffolds. | 2012-11-29 |
20120302493 | Cyclic Peptides As G-Protein Coupled Receptor Antagonists - The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions. | 2012-11-29 |
20120302494 | SYNERGISTIC COMBINATIONS OF POLYENE FUNGICIDES AND NON-RIBOSOMAL PEPTIDES AND RELATED METHODS OF USE - The present invention includes compositions comprising a synergistic fungicidal combination of a polyene fungicide and at least one lipopeptide and methods for using such compositions in controlling fungal pathogens. | 2012-11-29 |
20120302495 | INSECTICIDAL PROTEINS DERIVED FROM BACILLUS THURINGIENSIS - The present invention relates to the field of plant pest control, particularly insect control. Provided are nucleotide sequences from | 2012-11-29 |
20120302496 | NOVEL 24-MEMBERED CYCLOOCTADEPSIPEPTIDES FROM FUNGAL STRAINS AND THEIR USE AS ANTHELMINTICS OR ENDOPARASITICIDES - The present invention relates firstly to the discovery of the previously unknown 24-membered cyclooctadepsipeptides PF1022-V, PF1022-W, XRB-C894, XRB-C942, XRB-C976, XRB-C1010, XRB-C1044, XRB-E922, XRB-E956, XRB-E990, XRB-E1024, XRB-S958, XRB-S992, XRB-S1026, XRB-S1060 (in various isomeric forms) and to the processes for the preparation of the abovementioned cyclooctadepsipeptides by means of the fungal strains from the family Xylariaceae, in particular the genera | 2012-11-29 |
20120302497 | METHODS OF TREATING MEDICAL CONDITIONS USING CALCITONIN ANALOGS - The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like. | 2012-11-29 |
20120302498 | INSULIN LIKE PEPTIDES - It is described the preparation of Insulin like peptides, of chimeric Insulin like peptides and of their derivatives by the random combination of their chains A and their chains B and the pharmaceutical application of the obtained products. | 2012-11-29 |
20120302499 | STERILIZED, ACELLULAR EXTRACELLULAR MATRIX COMPOSITIONS AND METHODS OF MAKING THEREOF - Methods for sterilizing and decellularizing extracellular matrix materials are disclosed. Extracellular matrix compositions produced using the disclosed methods are also disclosed. | 2012-11-29 |
20120302500 | USE OF SOMATOSTATIN ANALOGS IN MENINGIOMA - The present invention relates to the use of a Somatostatin (SRIF) analog which has a high binding affinity to human SSTR1,2,3,5, or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical composition for the treatment of meningioma. | 2012-11-29 |
20120302501 | TREATMENT OF DIABETIC CARDIOMYOPATHY WITH A GLP-1 PEPTIDE - Hibernating myocardium is characterized by viable myocardium with impaired function due to localized reduced perfusion. Hibernating myocytes retain cellular integrity, but cannot sustain high-energy requirements of contraction. High plasma levels of catecholamines, such as norepinepherine, are believed to be predictive of mortality from hibernating myocardium. Likewise, high levels of catecholamines lead to cardiomyopathy in patients with diabetes. GLP-1 reduces plasma norepinepherine levels, and it thus is useful in a method of treating hibernating myocardium or diabetic cardiomyopathy. | 2012-11-29 |
20120302502 | MUCOSAL DELIVERY COMPOSITIONS COMPRISING A PEPTIDE COMPLEXED WITH A CROWN COMPOUND AND/OR A COUNTER ION - Compositions and methods are provided for mucosal delivery of peptides. The compositions include a stably hydrated peptide active agent complexed with a crown compound and/or a counter ion solubilized in a non-aqueous hydrophobic vehicle at a pH different from the pI of the peptide active agent. The methods include administering to a subject an effective amount of a composition of the disclosure. Other aspects include methods for the manufacture of the compositions of the disclosure. Also provided are compositions and kits that find use in practicing embodiments of the disclosure. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions. | 2012-11-29 |
20120302503 | PEPTIDES FOR PREVENTING OR TREATING A DISEASE OR DISORDER ASSOCIATED WITH CBP OR p300 MISREGULATION, AND METHODS FOR USE AND IDENTIFICATION THEREOF - Described herein are therapeutic peptides composed of a cell penetrating peptide, a peptide derived from the sequence of c-Myb, and a peptide derived from the sequence of CREB, useful for the treatment or prevention of a disease or disorder associated with CBP or p300 misregulation. | 2012-11-29 |
20120302504 | Method Of Reducing Injury To Mammalian Cells - A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor-neuronal protein interaction. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity, ischemic and traumatic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95/NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults, dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia, and traumatic brain injury (TBI) in rats. | 2012-11-29 |
20120302505 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY - Described herein are CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. Also disclosed are methods of using (e.g., to treat a disorder) the CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. | 2012-11-29 |
20120302506 | MASPIN-BASED TREATMENT AND PREVENTION OF CANCER - The present invention provides maspin-related compositions and methods of use thereof. In particular, the present invention provides maspin-related compositions, and methods or use thereof, for the promotion of cell adhesion. | 2012-11-29 |
20120302507 | Liquid Product of Botulinum Toxin Type A - Disclosed are a liquid product of botulinum toxin type A and a method for conserving the potency of botulinum toxin type A using a dextrose solution. Free of a stabilizer, such as albumin or gelatin, the liquid product of botulinum toxin type A completely excludes the possibility of cross infections such as AIDS and bovine spongiform encephalopathy. In addition, botulinum toxin type A is preserved as a liquid product in combination with a dextrose solution and can be clinically used as is, without the aid of physiological saline. Therefore, the liquid product enjoys the advantage of being convenient for use and avoiding a decrease in the potency as occurs upon dilution with physiological saline. Serving as a natural preserving and stabilizing agent, the dextrose solution allows botulinum toxin type A to be stored and distributed in the form of liquid phase over a long period of time and conserves the potency of the toxin at a constant level, which in turn guarantees constant clinical results. | 2012-11-29 |
20120302508 | SUSTAINED-RELEASE FORMULATION - The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic acid-glycolic acid copolymer having a weight average molecular weight of about 5,000 to about 40,000 or a salt thereof. The sustained-release formulation of the present invention slowly and stably release compound (I) or a salt thereof for a long time and exerts a medicinal effect of compound (I) or a salt thereof for a long time. Furthermore, the sustained-release formulation of the present invention, which improves patient's convenience by reducing the number of administration times, is an excellent formulation as a clinical medicine. | 2012-11-29 |
20120302509 | COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS - The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from | 2012-11-29 |
20120302510 | HISTONE DEACETYLASES, AND USES RELATED THERETO - The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo. | 2012-11-29 |
20120302511 | PEPTIDES BINDING TO THE DIMER INTERFACE OF THYMIDYLATE SYNTHASE FOR THE TREATMENT OF CANCER - Provided are peptides that bind to the thymidylate synthase protein, in particular to human thymidylate synthase (hTS) protein, for the treatment of cancer. Further provided are peptides that can bind at a binding site located at the interface of thymidylate synthase protein. These peptides range from 3 to 10, preferably 4-8 amino acids and have a sequence that binds to each subunit of the thymidylate synthase dimer at the level of dimer interface, stabilizing the dimeric inactive form of the thymidylate synthase enzyme. In addition, provided are pharmaceutical compositions including these compounds as active agents, and uses thereof for the treatment of cancer and to reverse or/and be active in cancer drug resistance. | 2012-11-29 |
20120302512 | ISOLATED LAMININ-421 - The present disclosure provides isolated laminin-421, methods for making recombinant laminin-421, and host cells that express recombinant laminin-421. The present disclosure also provides nucleic acid sequences encoding full length human laminin β2 chain, expression vectors and host cells thereof. | 2012-11-29 |
20120302513 | Mitochondrial Function Improver - Provided are a mitochondrial function improver, an energy consumption promoter, and a lipid combustion promoter which contain a fat globule membrane component as an active ingredient. | 2012-11-29 |
20120302514 | GLYCOCONJUGATES AND METHODS - Disclosed are compositions containing glycoconjugates and methods for making the functionalized glycoconjugates, which include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (iii) conjugates the saccharide to a carrier to form a glycoconjugate, and (iv) extracellularly expresses the glycoconjugate to form an extracellular glycoconjugate comprising a selectively reactive functional group. Methods for forming products at a cell further comprise contacting the functional group of the extracellularly expressed glycoconjugate with an agent that selectively reacts with the functional group to form a product. Subject compositions include cyto-compatible monosaccharides comprising a nitrogen or ether linked functional group selectively reactive at a cell surface and compositions and cells comprising such saccharides. | 2012-11-29 |