| 48th week of 2008 patent applcation highlights (11-27-08/11-27-08_49) part 49 |
| Patent application number | Title | Published |
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| 20080293873 | Water resistant molding material and producing method for the same - The invention provides a water resistant molding material that can be stably manufactured while being excellent in water resistance after dried, and a producing method for the water resistant molding material. The water resistant molding material comprises a binder resin containing a polyvinyl alcohol resin, a viscosity control agent, water and a filler, wherein the concentration of acetate ions is adjusted in the range from 500 to 12,000 ppm by blending, for example, an acetate ion controlling agent (such as NH | 11-27-2008 |
| 20080293874 | Polymers for the Dispersion of Pigments and Fillers - The invention relates to a polymer of the formula (I) | 11-27-2008 |
| 20080293875 | Oxetane Compound and Curable Composition Containing the Same - An object of the present invention is to provide a curable composition which: is excellent in reactivity, in particular, cationic polymerizability with respect to light and heat; and has good heat resistance. The object is carried out by an oxetane compound producible by a reaction between a silane compound having an epoxy group and an alkoxysilyl group, and a compound having an oxetane ring and an active hydrogen group. | 11-27-2008 |
| 20080293876 | Use of a crosslinkable silicone-based inverse emulsion for producing "breathable waterproof" coatings - Silicone coating on various soft supports, for instance textiles, made of synthetic polymers (polyamide, polyester) provides an efficient method for producing water impermeable and water permeable coatings, on soft supports, said method enabling to improve permeability to water vapor of the silicones while preserving impermeability to water. The inventive method enabling this consists mainly in: coating one of the surfaces of the support with a film formed by an invert water-in-oil silicone emulsion comprising a continuous oily silicone phase phi s, crosslinkable into elastomer and including a polyorganosiloxane (POS) A crosslinkable by addition polymerization, by cationic process or free-radical process; optionally a crosslinking organosilicon compound B; and optionally at least a catalyst C; an aqueous phase phi a; a stabilizing agent; and in ensuring crosslinking of the silicone phase phi s and elimination of water. The invention also concerns water impermeable and water vapor permeable soft polyamide or polyester substrates obtained by using an invert water-in-oil silicone emulsion. | 11-27-2008 |
| 20080293877 | Fireproof Composition - The present invention concerns a fireproof composition consisting of reticulated polysiloxane and raw carbon nanotubes with a “bound rubber” value greater than or equal to 15 grams of carbon nanotube, said carbon nanotubes representing between 0.05 and 1% of the total weight of said composition. | 11-27-2008 |
| 20080293878 | Ionically and/or Organometallically Functionalized Silicone Polymers Crosslinkable to High-Strength Elastomers - High strength silicone elastomers with enhanced physical properties are prepared from silicone polymers having ionic or organometallic functional groups, crosslinked through coulombic interactions and/or covalent bonds. | 11-27-2008 |
| 20080293879 | Coating composition for dielectric insulating film, dielectric insulating film prepared therefrom, and electric or electronic device comprising the same - The present invention relates to a coating composition for a dielectric insulating film comprising a) an organosiloxane polymer, b) first metal ions selected from the group consisting of Rb ions, Cs ions, and a mixture thereof, and c) an organic solvent, in which the first metal ions are comprised at 1 to 200 ppm based on the weight of the composition, a dielectric insulating film prepared therefrom, and an electric or electronic device comprising the same. | 11-27-2008 |
| 20080293880 | Liquid, Thermally Curable Mixtures, Their Preparation and Use - Liquid, thermally curable mixtures comprising,
| 11-27-2008 |
| 20080293881 | POLYMERIC ADDITIVES TO IMPROVE PRINT QUALITY AND PERMANENCE ATTRIBUTES IN INK-JET INKS - Two-part fixatives are provided in conjunction with overcoating at least one ink-jet ink printed on a print medium and comprise (1) at least one first reactive component comprising a reactive monomer or oligomer, the reactive species selected from the group consisting of iso-cyanates and epoxy-terminated oligomers, optionally in a vehicle, and (2) at least one second component selected from the group consisting of polyols and polyvinyl alcohols, plus one or more base catalysts, optionally in a vehicle. The two components and catalyst(s) are deposited on the print medium on which the ink-jet ink has been printed, and react to form a hydrophobic polymer overcoating the printed ink and having a glass transition temperature within a range of −20° C. to +50° C. and a melting temperature within a range of 30° C. to 100° C. | 11-27-2008 |
| 20080293882 | Polyester Compositions Which Comprise Cyclobutanediol and Certain Thermal Stabilizers, and/or Reaction Products Thereof - Described are polyesters containing (a) a dicarboxylic acid component having from about 80 to 100 mole % of terephthalic acid or an ester thereof, and up to about 10 mole % of an aromatic dicarboxylic acid or aliphatic dicarboxylic acid or esters thereof; and (b) a glycol component having from about 40 to 65 mole % of 2,2,4,4-tetramethyl-1,3-cyclobutanediol, and from about 35 to 60 mole % of 1,4-cyclohexanedimethanol; | 11-27-2008 |
| 20080293883 | Process for Production of (Co)Polyamide Nanocomposite Materials - The present invention concerns a process for preparing a polymer nanocomposite composition, the process comprising: a) mixing a melted polyamide of inherent viscosity under 1 and a nanofiller to disperse the nanofiller in said polyamide; and b) subjecting the previous mixture to polymerization conditions to polymerize the polyamide and to form the polymer nanocomposite composition. Advantageously the inherent viscosity of the polyamide is under 0.9 and preferably between 0.4 and 0.8. Step a) is carried out in an extruder or a mixer. Advantageously a mono or twin-screw extruder is used. Step b) could be made either in melted state or in solid state. It is easier to make it in the same apparatus as step a). Should step a) is carried out in an extruder, step b) is made in the same extruder. Polymerization of step b) can be carried with a catalyst and/or by having the extruder zones in which step b) takes place to operate under vacuum. | 11-27-2008 |
| 20080293884 | SYNTHETIC RESIN EMULSION POWDER - Disclosed is a synthetic resin emulsion powder obtained by spray-drying a composition that comprises an emulsion (A) where the dispersoid is a polymer that having one or more unsaturated monomer units selected from ethylenic unsaturated monomers and dienic monomers, and a polyvinyl alcohol (B) having, in the molecule, from 1 to 12 mol % of ethylene units. The emulsion powder has good redispersibility and good water resistance. Its redispersion well form good films and has good storage stability at low temperatures. The emulsion powder is favorable for additives to hydraulic substances, as it well disperses in hydraulic substances such as cement mortar and gives hardened articles of high mechanical strength. The emulsion powder is also favorable for joint materials for hydraulic substances, as its adhesiveness and durability are both good and gives jointed articles of high mechanical strength. | 11-27-2008 |
| 20080293885 | Reactive Emulsion and Process for Producing the Same - The present invention provides a reactive emulsion capable of exerting a superior cross-linking ability, while reducing an amount of expensive additionally polymerizable oxazoline to be used. The problem can be solved with a reactive emulsion containing a core part composed of fine particles of an acrylate-based emulsion and a shell part composed of a polymer containing an oxazoline group, locating around said core part. | 11-27-2008 |
| 20080293886 | Use Of Amphiphilic Block Copolymers For Producing Polymer Blends - Production of polymer blends using amphiphilic block copolymers which comprise poly-isobutene blocks and also polyoxyalkylene blocks, as compatibilizers. | 11-27-2008 |
| 20080293887 | Stretched product of thermoplastic resin composition having good gas-barrier properties - A stretched product which is produced form a thermoplastic resin composition containing 10 to 98% by weight of a polystyrene resin A and 2 to 90% by weight of a polyamide resin B. The polyamide resin B contains a m-xylylene-containing polyamide which is constituted of a dicarboxylic acid constitutional unit and a diamine constitutional unit 70 mol % or more of which is derived from m-xylylenediamine. The semi-crystallization time of the polyamide resin B is 200 s or more at 140° C. when determined by a depolarized light intensity method. The stretched product has good gas-barrier properties and transparency. | 11-27-2008 |
| 20080293888 | Photocrosslinkable Materials - A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound. | 11-27-2008 |
| 20080293889 | NITRILE RUBBERS - An improved polymerization and work-up process makes it possible to produce specific nitrile rubbers which have a specific calcium and chloride content and have a particularly high storage stability. | 11-27-2008 |
| 20080293890 | Elastomeric Resin Compositions with Improved Resistance to Draw Resonance - This invention relates to polyolefin compositions. In particular, the invention pertains to elastic polymer compositions that can be more easily processed on cast film lines, extrusion lamination or coating lines due to improved resistance to draw resonance. The compositions of the present invention comprise an elastomeric polyolefin resin and a high pressure low density type resin. The preferred compositions of the present invention comprise from 88 to 99 percent elastomer or plastomer and from 1 to 12 percent by weight of a high pressure low density type resin. | 11-27-2008 |
| 20080293891 | Process for coagulating fluoroelastomers - In a process for the manufacture of fluoroelastomers, a water-soluble polymeric coagulant is employed that is an aqueous solution of polyethyleneimine or its copolymers. | 11-27-2008 |
| 20080293892 | Halogenation Processes - The invention discloses improved processes to halogenate polymers. In particular, the invention discloses to improved processes to halogenate polymers made from C | 11-27-2008 |
| 20080293893 | POLY(ESTER AMIDE) BLOCK COPOLYMERS - Provided herein is a copolymer that includes a soft block (A) and a hard block (B) comprising a tyrosine di-peptide. The copolymer can be any of AB, ABA or BAB type block copolymers. The soft block can include a PEA polymer. | 11-27-2008 |
| 20080293894 | METHOD OF IMPROVING THERMAL STABILITY OF POLY-3-HYDROXYBUTYRATE - The present invention discloses a method of improving the thermal stability of poly-3-hydroxybutyrate (PHB). The thermal stability of PHB was improved by grafting maleic anhydride (MA) onto the PHB through various processes. It has been proved that purified grafted PHB had a higher degradation temperature, a better thermal stability than the pristine PHB, and was not easy to decrease molecular weight by heat treatment. At the same time, the crystallization rate, the melting temperature and crystallinity were all increased. The MA was effectively grafted onto PHB by processes of solution grafting, melt grafting, mechanical grafting methods and so on. The grafting degree of MA was changed with the increasing amounts of the initiator and MA. The degradation temperature of the PHB was significantly increased by MA grafting because the degradation was blocked in the formation of six-member ring by the steric hindrance of the grafted MA. The PHB grafted with the mechanical grafting method was not easy to generate scission degradation during reaction, and showed the best thermal stability and forming ability. The initial degradation temperature of PHB was increased at least 50° C. | 11-27-2008 |
| 20080293895 | Polymerization process using a supported, treated catalyst system - The present invention relates to a supported, treated catalyst system and its use in a process for polymerizing olefin(s). More particularly, it provides a supported, treated catalyst system produced by a process comprising the steps of: (a) forming a supported bimetallic catalyst system comprising a first catalyst component and a metallocene catalyst compound; and (b) contacting the supported bimetallic catalyst system of (a) with at least one methylalumoxane-activatable compound. | 11-27-2008 |
| 20080293896 | Diene polymerisation - A process and catalyst for producing homopolymers or copolymers of conjugated dienes by polymerising the monomer with a catalyst system comprising (A) a first transition metal compound selected from Cr, Mo and W compounds, and a second transition metal compound selected from Fe Co and Ni compounds (B) a catalyst modifier (eg triphenyl phosphine) and optionally (C) one or more catalyst activators (eg MAO). The cis, trans and 1,2-vinyl microstructure of the produced diene polymer can be controlled. | 11-27-2008 |
| 20080293897 | Magnesium Dichloride-Ethanol Adducts and Catalyst Components Obtained Therefrom - Adducts are provided comprising MgCl | 11-27-2008 |
| 20080293898 | Catalyst for Olefin Polymerization and Polymerization Method Using the Same - Disclosed is a catalyst for olefin polymerization, comprising: Component [A]: a prepolymer obtained by olefin prepolymerization on solid titanium catalyst component having an average particle size of 25 to 70 μm produced by contacting of a solid component (i) having an average particle size of 26 to 75 μm, containing magnesium, titanium, halogen, and an electron donor (c | 11-27-2008 |
| 20080293899 | Methods For Oligomerizing Olefins - The present invention provides a method of producing oligomers of olefins, comprising reacting olefins with a catalyst under oligomerization conditions. The catalyst can be the product of the combination of a chromium compound and a pyridyl amine or a heteroaryl-amine compound. In particular embodiments, the catalyst compound can be used to trimerize or tetramerize ethylene to 1-hexene, 1-octene, or mixtures of 1-hexene and 1-octene. | 11-27-2008 |
| 20080293900 | Method for Producing Highly Reactive Isobutylene Homo-or Copolymers Using Metal-Containing Catalyst Complexes - Preparation of highly reactive isobutene homo- or copolymers having M | 11-27-2008 |
| 20080293901 | POLYMERS AND COMPOUNDS PREPARED WITH ALPHA-METHYLENE LACTONES, METHODS THEREFOR, AND COATINGS - A method of preparing functional materials for coatings, which may be polymers, oligomers, or compounds, includes polymerizing an alpha-methylene lactone that is reacted, before or after polymerization, with a hydroxy-functional reactant. Coating can be prepared with the reaction products. | 11-27-2008 |
| 20080293902 | MERCAPTAN MIXTURE - A novel mixture containing a number of particular mercaptans, a process for preparing it and its use as advantageous molecular weight regulator in the production of synthetic rubbers are provided. | 11-27-2008 |
| 20080293903 | Optical Organic Polymer - An organic polymer suitable for preparing optical waveguides or optical fibers and methods of making same are described. The polymer is a homo- or copolymer having an olefinic backbone with a pendant group comprising fluorinated aromatic and aliphatic moieties, and is cross-linkable. Polymers having refractive index over a wide range may be prepared by selecting specific constituents of the pendant group. | 11-27-2008 |
| 20080293904 | High Melt Flow Fluoropolymer - The present invention relates to a partially-crystalline copolymer comprising tetrafluoroethylene, hexafluoropropylene in an amount corresponding to HFPI of from about 2.8 to 5.3, and preferably from about 0.2% to 3% by weight of perfluoro(alkyl vinyl ether), said copolymer having less than about 50 ppm alkali metal ion, having a melt flow rate of within the range of about 30±3 g/10 min, and having no more than about 50 unstable endgroups/10 | 11-27-2008 |
| 20080293905 | MULTICOORDINATED METAL COMPLEXES FOR USE IN METATHESIS REACTIONS - Improved catalysts useful in alkyne or olefin metathesis are made by bringing into contact a multi-coordinated metal complex comprising a multidentate Schiff base ligand, and one or more other ligands, with a selected activating compound under conditions such that at least partial cleavage of a bond between the metal and the multidentate Schiff base ligand of said metal complex occurs. | 11-27-2008 |
| 20080293906 | BIOACTIVE AND BIOCOMPATIBLE POLYURETHANE-BUTHANEDIOL-GLYCOSAMINOGLYCAN SALT COPOLYMERS - A bioactive and biocompatible polyurethane-butanediol-glycosaminoglycan copolymer for use in medical implant devices. The biocompatible urethane component being the reaction product of 4,4′-methylene-di-(p-phenyl isocyanate) and poly(tetramethylene oxide)n and further reacted with 1,4-butanediol, wherein n=10 to 40. The bioactive glycosaminoglycan being a salt of hyaluronic acid, such as a cetylpyridinium salt acid having 5 to 10,000 repeating units or a salt of heparin, such as a dimethyldioctadecylammonium salt of heparin has 5 to 65 repeating units or a suitable salt of dermatan sulfate. The weight content of the bioactive glycosaminoglycan is an amount sufficient to render the copolymer bioactive. The copolymers described herein have excellent hemocompatibility and biocompatibility. | 11-27-2008 |
| 20080293907 | Method for Preparing Ss-Ketocarbonyl-Functional Organo-Silicium Compounds - β-ketocarbonyl-functional organosilicon compounds are prepared by reacting amino organo-functional organosilicon compounds with a diketene in the presence of a compound which inhibits the reaction of amine groups with β-ketocarbonyl compounds. | 11-27-2008 |
| 20080293908 | Polyester Prepolymers - The invention relates to prepolymers containing alkoxysilane groups based on special, low-viscosity polyester polyols, which exhibit particularly high tensile strength, a process for the production thereof and their use as a binder for adhesives, primers or coatings. | 11-27-2008 |
| 20080293909 | Covered Heteroaromatic Ring Compound - The present invention provide a covered heteroaromatic ring compound whose hetero ring effectively is covered and that is suitable for electronic materials and the like. For example, following Scheme 1 below, first, a thiophene monomer unit (1T) is synthesized, and then oligomers (2T) to (16T) are synthesized by repeating oxidative polymerization. The hetero ring is not limited to thiophene, and may be furan or pyrrole, for example. Also, substituents on silicon are not limited to those in Scheme 1, and any substituents may be used. The degree of polymerization and the synthesis method are not limited to those in Scheme 1. In the compound of the present invention, π electronic conjugation effectively is kept as shown in the ultraviolet and visible absorption spectrum in FIG. | 11-27-2008 |
| 20080293910 | ADHESIVE FORMULATIIONS - The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a multifunctional amine or multifunctional polyol core, with isocyanate and/or polyalkylene oxide arms, which may optionally be capped with electrophilic or nucleophilic groups. These biocompatible components may, in embodiments, be combined with optional cross linkers to form adhesive and/or sealant compositions. | 11-27-2008 |
| 20080293911 | ANHYDRIDE AND RESORCINOL LATENT CATALYST SYSTEM FOR IMPROVING CURE CHARACTERISTICS OF PHENOLIC RESINS - An anhydride and resorcinol latent catalyst system for a phenolic resole resin provides a resin having long pot life and long shelf life, yet cures quickly thereafter. | 11-27-2008 |
| 20080293912 | High molecular weight polyester polymers with reduced acetaldehyde - Polyester compositions, especially polyethylene terephthalate homopolymer and copolymers, are disclosed containing titanium catalysts and catalyst deactivator added late in the manufacturing processing having reduced acetaldehyde generation rates. The polyester compositions are low in free acetaldehyde, making them suitable for fabrication into beverage containers for relatively tasteless beverages such as bottle water. Furthermore, the polyesters are polymerized to a high inherent viscosity in reduced processing time, without the necessity of further polymerization in the solid state, and in the absence of acetaldehyde scavengers leading to polyester polymers having reduced color. | 11-27-2008 |
| 20080293913 | PROCESS TO PRODUCE POLYOLS - A process for producing oleochemical polyols comprises the steps of epoxidizing unsaturated oil using an organic acid together with oxygenated water or a per-acid to obtain epoxidized oil; washing the epoxidized oil with salt water to remove unused organic acid together with oxygenated water or a per-acid; neutralizing acidic condition of the washed epoxidized oil with a base; washing the neutralized epoxidized oil with a salt solution until the pH of the neutralized epoxidized oil reaching 6.5 to 7.5 to removed the base residue; drying the washed neutralized epoxidized oil under vacuum; and reacting the washed neutralized dried epoxidized oil with polyhydric alcohol in the presence of boron trifluoride-diethylether complex to produce the oleochemical polyols. The oleochemical polyols are then subjected to the same washing, neutralizing, washing and drying process as in preparing the washed neutralized dried epoxidized oil. | 11-27-2008 |
| 20080293914 | Liquid Nonionic Surfactants for Emulsion Polymerization and Other Applications - The present invention provides a high actives liquid nonionic surfactant concentrate that includes a fatty alcohol alkoxylate having an alkylene oxide content of about 10-100 moles and at least one other nonionic surfactant alkoxylate having an alkylene oxide content of about 4-12 moles. The liquid surfactant concentrate may be utilized in a variety of applications, such as emulsion polymerization or in the formulation of agrochemical compositions. | 11-27-2008 |
| 20080293915 | Nanoscale Neuromodulating Platform For Retina Neuron Activation Apparatus and Method - Postsynaptic membrance receptor proteins of retinal neurons proximal to the rods and cones mediate the transmission of visual signals at multiple types of chemical synapses in the normally functioning retina, and there is reason to believe that these proximal retinal neurons in certain cases remain functional despite the disease-induced loss of rod and cone visual signaling. The invention is a nanoscale molecular structure that can selectively attach to the extracellular face of specific membrane receptors of post-photoreceptor retinal neurons and, by modulating the postsynaptic receptor's activity in response to light, restore visual signaling in retina damaged by photoreceptor degenerative disease. | 11-27-2008 |
| 20080293916 | Hla-Binding Peptide, and Dna Fragment and Recombinant Vector Coding for Said Hla-Binding Peptide - An HLA-binding peptide binding to an HLA-A type molecule, said HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 60, and not less than 8 and not more than 11 amino acid residues is provided. Any of the amino acid sequence is predicted to have the binding property to a human HLA-A24 molecule or a human HLA-A2 molecule by a predicting program using an active learning experiment method as illustrated in FIG. | 11-27-2008 |
| 20080293917 | Peptide Purification By Means Of Metal Ion Affinity Chromatography - A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S. | 11-27-2008 |
| 20080293918 | METHOD AND APPARATUS FOR EXTRACTION OF PROTEIN MATERIAL FROM ARTHROPOD GLANDS AND A MEMBRANE FORMED THEREFROM - An apparatus and method for the extraction of material from glands of arthropods. The apparatus comprises a container in which at least part of the glands are placed and a buffer solution at least partially immersing the glands. Gland material is collected in the material collection area of container. In use the material is released from glands into the buffer solution and sedimented at the bottom of the container. The method comprises: a first step of removing from a body of the arthropod the gland containing at least partially the material; a second step of making an opening in an epithelium of the gland; and a third step of placing the gland in a container at least partially immersed in a buffer solution such that the materials exit the glands and sediments in the material collection area of the container. | 11-27-2008 |
| 20080293919 | Fibrous Protein Fusions and Use Thereof in the Formation of Advanced Organic/Inorganic Composite Materials - The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation. | 11-27-2008 |
| 20080293920 | Arginine Analogs, and Methods for Their Synthesis and Use - The present invention relates to novel arginine analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or free thiol (—SH) group, thereby providing a convenient linkage chemistry for coupling to a suitable group on a target such as a protein, polypeptide, detectable label or solid phase, and at a site distal to the guanidino group. Arginine analog conjugates are useful for generating antibodies that can bind specifically with dimethylarginine, which can be detected using such antibodies in immunoassays. | 11-27-2008 |
| 20080293921 | Production and Use of Novel Peptide-Based Agents for Use with Bi-Specific Antibodies - The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. In preferred embodiments, the hapten is histamine-succinyl-glycine (HSG). In more preferred embodiments, the at least one arm comprises the CDR sequences of the HSG-binding 679 antibody. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. In one embodiment, the invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them. | 11-27-2008 |
| 20080293922 | BETA-AMYLOID BINDING FACTORS AND INHIBITORS THEREOF - The present invention relates to a VEGF polypeptide that binds to Aβ. The present invention also relates to a compound that sequesters Aβ. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits the binding of VEGF to Aβ, and thus relates to prevention and treatment of Alzheimer's Disease. | 11-27-2008 |
| 20080293923 | CRYSTAL STRUCTURE OF THE COMPLEX OF HEPATOCYTE GROWTH FACTOR BETA CHAIN WITH MET RECEPTOR AND METHODS OF USE - The disclosure provides a crystal structure of a complex of the HGF β-chain with am extracellular fragment of the Met receptor, as well as use of the crystal structure in the design, identification, and selection of ligands that modulate the Met Receptor and the interaction of HGF with the Met receptor. | 11-27-2008 |
| 20080293924 | Process For the Isolation and/or Purification of Proteins - The invention relates to the process for the isolation and/or purification of biologically active proteins, preferably TNF-alpha or TNF-alpha analogues. The process of the present invention results in the production of high yields of proteins, preferably TNF-alpha or TNF alpha analogues with a purity of greater than 98%. The described process is particularly suitable for the industrial production of proteins, preferably TNF-alpha or TNF-alpha analogues. | 11-27-2008 |
| 20080293925 | Affinity Adsorbents for Plasminogen - For the separation, removal, isolation, purification, characterisation, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C | 11-27-2008 |
| 20080293926 | Preparation of Biomolecules - The present invention relates to a method of separating a target from a liquid, which includes providing a polymer in an aqueous liquid, which polymer comprises at least one hydrophobic portion; contacting the polymer-containing liquid with the liquid comprising the target; applying a stimulus to the resulting mixture; and maintaining it until a reversible phase separation is obtained. One phase is polymer-rich and contains target(s) and another phase is polymer-poor. By either maintaining the stimulus, or applying a different stimulus and maintaining it, the polymer-rich phase is transformed into a substantially solid phase. | 11-27-2008 |
| 20080293927 | METHOD FOR PREPARING PELLETED LIGNOCELLULOSIC ION EXCHANGE MATERIALS - The invention discloses a method for preparing pelleted lignocellulosic ion exchange materials for use in a variety of industrial and municipal water treatment applications. The method involves milling, sifting, binding, extruding, cutting, and baking steps. The resultant pellet is suitable for use in ion exchange columns and can be regenerated. | 11-27-2008 |
| 20080293928 | Cytochrom P450 oxygenases - Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3. | 11-27-2008 |
| 20080293929 | SYNTHESIS OF SULFURIZED OLIGONUCLEOTIDES - Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported. | 11-27-2008 |
| 20080293930 | 3' end tagged oligonucleotides - The present invention provides compositions comprising oligonucleotides that have 3′ end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3′ end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions. | 11-27-2008 |
| 20080293931 | Methods and compositions for the removal of nucleic acid amplification inhibitors - An improved method for preparing nucleic acid extracts from environmental samples contaminated by polymerase inhibitors such as humic and fulvic acids is provided. The methods of the invention utilize chemical compositions capable of precipitating humic and/or fulvic acids from organic samples. The methods may be used in connection with the preparation of DNA and RNA extracts, thereby providing purified preparations suitable for amplification using PCR, RT-PCR, and other nucleic acid amplification technologies. Reagent kits for preparing a purified nucleic acid-containing extract from an environmental sample of soil, fluid, or organic particles, using the chemical compositions of the invention are also provided. | 11-27-2008 |
| 20080293932 | PHTHALOCYANINE RECORDING LAYER OF OPTICAL RECORDING MEDIA - A phthalocyanine compound of formula (I) is provided for use in a recording layer of an optical recording media. | 11-27-2008 |
| 20080293933 | PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE COMPOUNDS - The invention relates to a process for the optical resolution of a dibenzo[b,d]azepinone derivative of formula II, | 11-27-2008 |
| 20080293934 | Method for Chiral Inversion of (S)-(+)-and (R)-(-)-10,11-Dihydro-10-Hydroxy-5H-Dibenz/B,F/Azepine-5-Carboxamide and Optically Enriched Mixtures Thereof - A method for chiral inversion of optically pure or optically enriched mixtures of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (I) and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (II). | 11-27-2008 |
| 20080293935 | Method for the Production of 2,4,6- Trimercapto-1,3,5-Triazine - The present invention is directed towards a method for the production of 2,4,6-trimercapto-1,3,5-triazine (TMT-H | 11-27-2008 |
| 20080293936 | Novel inhibitors of lysyl oxidase - The present invention concerns novel pyridazine-3-on- and pyrazol-3-on derivatives, methods of synthesizing such, a pharmaceutical agent containing pyridazine-3-on- and pyrazol-3-on derivatives as well as the use of the compounds for the prophylaxis or treatment of fibrotic diseases and/or pathologic remodelling and the use of said compounds for the expansion of stem cells. | 11-27-2008 |
| 20080293937 | n-Type Thiophene Semiconductors - The new fluorocarbon-functionalized and/or heterocycle-modified polythiophenes, in particular, α,ω-diperfluorohexylsexithiophene DFH-6T can be straightforwardly prepared in high yield and purity. Introduction of such modifications to a thiophene core affords enhanced thermal stability and volatility, and increased electron affinity versus the unmodified compositions of the prior art. Evaporated films behave as n-type semiconductors, and can be used to fabricate thin film transistors with FET mobilities ˜0.01 cm | 11-27-2008 |
| 20080293938 | Novel Process for the Preparation of Didanosine Using Novel Intermediates - present invention relates to novel crystalline alkali metal and alkaline earth metal salts of 2′,3′-dideoxy-2′,3′-didehydroinosine. The present invention also provides a novel process for preparation of didanosine in high yield and purity using novel intermediates. Thus, for example, 5′-O-acetyl-2′,3′-dideoxy-2′,3′-didehydroinosine is reacted with monomethyl amine to give 2′,3′-dideoxy-2′,3′-didehydro inosine, which is then reacted with sodium hydroxide and crystallized to give crystalline 2′,3′-dideoxy-2′,3′-didehydroinosine sodium salt. 2′,3′-Dideoxy-2′,3′-didehydroinosine sodium salt is hydrogenated using raney nickel catalyst in aqueous medium and then neutralized with hydrochloric acid to yield didanosine. | 11-27-2008 |
| 20080293939 | QUINAZOLINONE DERIVATIVES USEFUL AS ANTI-HYPERALGESIC AGENTS - The present invention relates to quinazolinones of formula (I) wherein R | 11-27-2008 |
| 20080293940 | Amide Derivative and Medicine - The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. | 11-27-2008 |
| 20080293941 | Method For Production Of 1-Alkyl-3-Phenyluracils - The present invention relates to a process for preparing 1-alkyl-3-phenyluracils of the formula I | 11-27-2008 |
| 20080293942 | Methods of Preparing 2-Imidazol-1-Yl-4-Methyl-6-Pyrrolidin-2-Yl-Pyrimidine and 4-(1-Alkylpyrrolidin-2-Yl)-2-(1H-Imidazol-1-Yl)-6-Methylpyrimidine Derivatives - The present invention is directed to a novel, high yield method for preparing 2-imidazol-1-yl-4-methyl-6-pyrrolidin-2-yl-pyrimidine, particularly to a method of preparing 4-(1-alkylpyrrolidin-2-yl)-2-(1H-imidazol-1-yl)-6-methylpyrimidine, more particularly, 2-(2-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)pyrrolidrn-1-yl)-N-(benzo[d][1,3]dioxol-5-yh-nethyl)-N-methylethanamine. These compounds and pharmaceutical compositions thereof are inhibitors of nitric oxide synthase, are selective for inducible nitric oxide synthase, and are useful in treating diseases and disorders including inflammation and pain. | 11-27-2008 |
| 20080293943 | Process for the Preparation of 5-(4-[4-(5-Cyano-3-Indolyl)Butyl]-1-Piperazinyl)Benzofuran-2-Carboxamide - The invention relates to a process for the preparation of 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxamide and/or one of its physiologically acceptable salts, characterised in that a compound of the formula (I), in which L denotes Cl, Br, I, SO | 11-27-2008 |
| 20080293944 | Piperazinyl Compounds - Disclosed are new dihydropteridinones of general formula (I) | 11-27-2008 |
| 20080293945 | (Pentaphenyl)phenyl Group Containing Compound, Polymeric Derivative Thereof And Method For Forming The Same - The present invention discloses an iridium complex containing a (pentaphenyl)phenyl ligand, having the following general equation: | 11-27-2008 |
| 20080293946 | Process for Preparing Zolpidem Hemitartrate and Tartrate Polymorphs - A method for preparing a polymorph of a hemitartrate salt of a compound having the structure: comprising dissolving a free base form of the compound in a liquid medium comprising an alcohol and a tartrate derivative to form a solution comprising the compound, the alcohol, and the tartrate derivative; heating the solution to a temperature sufficient to dissolve the compound and the tartrate derivative; and cooling the solution to a temperature sufficient to precipitate the hemitartrate salt of the compound. | 11-27-2008 |
| 20080293947 | Method of Preparation for Imidazolepyridines - The present invention relates to an improved process for preparing imidazo[1,2-a]pyridine-3-acetamides and more particularly, 6-methyl-2-p-tolylH-imidazo[1,2-a]pyridine. | 11-27-2008 |
| 20080293948 | PROCESS FOR THE PREPARATION OF KETO COMPOUNDS - A process for the preparation of 4-[1-oxo-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethylbenzeneacetic acid, useful as an intermediate for the preparation of fexofenadine, is provided. | 11-27-2008 |
| 20080293949 | Novel heterocyclic analogs of diphenylethylene compounds - Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis. | 11-27-2008 |
| 20080293950 | Production Process of Compound Having Anti-Hcv Action and Intermediate Thereof - A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. | 11-27-2008 |
| 20080293951 | Amin Derivative, and Production Method and Use Thereof - Disclosed is a benzonitrile derivative which is useful as a production intermediate for benzylamine derivative represented by the general formula (5) below and s secondary amine derivative represented by the general formula (9) below. Also disclosed are a method for producing such a benzonitrile derivative and a use thereof as a bactericide. Specifically disclosed are a novel benzonitrile derivative represented by the general formula (1) below, a salt thereof, a production method thereof, and a use thereof as a pharmaceutical intermediate or a bactericide. [Chemical formula 1] (5) (In the formula, n represents an integer of 0-3, and R | 11-27-2008 |
| 20080293952 | Method for the Preparation of (S)-N-Methyl-3-(1-Naphthyloxy)-3-(2-Thienyl)Propylamine Hydrochloride (Duloxetine) - A method of preparation of (S)—N-methyl-3-(1-naphthyloxy)-3-(2-mienyl)propylamine of Formula (I) and its pharmaceutically acceptable salts, comprising a) reaction of (RS)—N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with optically active D-tartaric acid or an acid salt derived from D-tartaric acid forming a mixture of diastereoisomeric salts of N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine and D-tartaric acid (2:1), b) isolation of the salt (S)—N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine/D-tartrate (2:1) from the mixture of diastereoisomeric salts in an organic solvent, water or a mixture thereof and release of (S)—N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by action of an inorganic or organic base, c) demethylation of (S)—N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by action of an alkylchloroformate of formula ClCOOR (R=C | 11-27-2008 |
| 20080293953 | Chiral spiro compounds and their use in asymmetric catalytic reactions - The present invention provides a chiral ligand, represented by a formula or its enantiomer: | 11-27-2008 |
| 20080293954 | Process For Synthesizing Trioxymethylene Using Ionic Liquid - The present invention relates to a process for synthesizing trioxymethylene, wherein an aqueous solution of formaldehyde is used as the reactant; and an acidic ionic liquid in an amount of from 0.01 to 10 wt % is used as a catalyst. | 11-27-2008 |
| 20080293955 | Method for Producing Vitamin E-Adsorbates - The present invention relates to a process for preparing adsorbates of at least one vitamin E compound in adsorbed form on a silica support, comprising, as the essential step, the mixing of the corresponding vitamin E compound with the silica support under reduced pressure. The invention further relates to adsorbates which are preparable by the process mentioned. | 11-27-2008 |
| 20080293956 | METHOD OF PRODUCING BIODIESEL - This invention involves a kind of fatty acid methyl ester (bio-diesel fuel), especially the method of obtaining ester-like substances by means of chemical alterations of oil. | 11-27-2008 |
| 20080293957 | Process for Preparing Organically Modified Layered Double Hydroxide - The invention relates to a process for preparing an organically modified layered double hydroxide having a distance between the individual layers of the layered double hydroxide of above 1.5 nm and comprising an organic anion as charge-balancing anion, the process comprising the steps of: (a) preparing a precursor suspension comprising a divalent metal ion source and a trivalent metal ion source; (b) solvothermally treating the precursor suspension to obtain the layered double hydroxide, wherein an organic anion is added before or during the formation of the layered double hydroxide of step (b), or following the formation of the layered double hydroxide, so as to obtain the organically modified layered double hydroxide, with the proviso that deoxycholic acid is not the sole organic anion. The invention further pertains to a process for preparing an organically modified layered double hydroxide having a distance between the individual layers of the layered double hydroxide of above 1.5 nm and comprising an organic anion as charge-balancing anion, the process comprising the steps of: (a) preparing a precursor suspension comprising a divalent metal ion source and a trivalent metal ion source; (b) thermally treating the precursor suspension to obtain the layered double hydroxide, wherein an organic anion is added before or during the formation of the layered double hydroxide of step (b), or following the formation of the layered double hydroxide, so as to obtain the organically modified layered double hydroxide, with the proviso that in step a) the trivalent metal ion source is not reacted with the organic anion at a temperature of between 60 and 85° C. for 4 to 8 hours prior to the addition of the divalent metal ion source and step b) is subsequently carried out at a temperature of 90 to 95° C. for 4 to 8 hours. | 11-27-2008 |
| 20080293958 | Process for Preparing Unsaturated Organosilicon Compounds - Unsaturated organosilicon compounds are prepared by the reaction of a halo-functional organosilicon compound with a salt of an unsaturated carboxylic acid in the presence of a tertiary phosphine. | 11-27-2008 |
| 20080293959 | COMPOSITIONS USEFUL AS CHROMATOGRAPHY STATIONARY PHASES - The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent. The current invention also provides methods of making and using the compounds and compositions of the invention. | 11-27-2008 |
| 20080293960 | Process For The Preparation Of Diaryl Carbonates Or Arylalkyl Carbonates From Dialkyl Carbonates - The invention provides a process for the preparation of diaryl carbonates and/or alkylaryl carbonates from dialkyl carbonates and aromatic hydroxy compounds using one or more intermediate condensers for improving heat integration. | 11-27-2008 |
| 20080293961 | PROCESS FOR THE PURIFICATION OF 1,4-BUTANEDIOL MONONITRATE - A process for the purification of | 11-27-2008 |
| 20080293962 | Novel compounds of the N-acylamino amide family compositions comprising them and uses thereof - The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin ageing caused by decrease of skin elasticity and/or by collagen degradation in the structure for tissues. | 11-27-2008 |
| 20080293963 | PROCESS FOR PREPARATION ISOSULFAN BLUE - A process for the preparation of isosulfan blue (Active Pharmaceutical Ingredient) is provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon mild oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. | 11-27-2008 |
| 20080293964 | Process for Preparing High Purity Terephthalic Acid - The present invention relates to a process for preparing high purity terephthalic acid by catalytic, liquid phase oxidation of p-xylene utilizing a partially homogeneous reaction in the presence of a very specific catalyst. The process produces a high purity terephthalic acid without the secondary purification step currently practiced. | 11-27-2008 |
| 20080293965 | Process for the Dynamic Resolution of (Substituted) (R)- or (S)- Mandelic Acid - The present invention relates to a process for the resolution of mandelic acid derivative enantiomers from (racemic) mixtures by salt formation (see, for example, formula IIa) with chiral base cyclic amides, and racemisation of the unresolved enantiomer in the same process, wherein an additional racemising base may optionally be used, employing an acid:total base (i.e. cyclic amide and optional additional base) molar ratio of at least 1:1; provided that the cyclic amide base is present in a molar ratio of at least 0.75; and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; wherein R is selected from CHF | 11-27-2008 |
| 20080293966 | Control of impurities in reaction product of rhodium-catalyzed methanol carbonylation - The present invention relates to carbonylation of methanol, methyl acetate, dimethyl ether or mixtures thereof to produce glacial acetic acid, and more specifically to the manufacture of glacial acetic acid by the reaction of methanol, methyl acetate, dimethyl ether or mixtures thereof with carbon monoxide wherein the product glacial acetic acid contains low impurities. | 11-27-2008 |
| 20080293967 | Control of formic acid impurities in industrial glacial acetic acid - This invention relates to carbonylation of methanol, methyl acetate, dimethyl ether or mixtures thereof to produce glacial acetic acid, and more specifically to the manufacture of glacial acetic acid by the reaction of methanol, methyl acetate dimethyl ether or mixtures thereof with carbon monoxide wherein the product glacial acetic acid contains low formic acid impurities. | 11-27-2008 |
| 20080293968 | Method for regenerating catalyst for the production of methacrylic acid and process for preparing methacrylic acid - A catalyst for the production of methacrylic acid comprising a heteropolyacid compound containing phosphorus and molybdenum is regenerated by a method comprising the steps of drying a mixture containing a deactivated catalyst, an ammonium ion, a nitrate ion and water, molding the dried mixture, firstly calcining the molded product in an atmosphere of an oxidizing gas at a temperature of 360 to 410° C., and then secondly calcining the product in an atmosphere of a non-oxidizing gas at a temperature of 420 to 500° C. The regenerated catalyst has substantially the same catalytic activity as a fresh catalyst in a gas phase catalytic oxidation reaction of methacrolein, isobutylaldehyde, isobutane or isobutyric acid to prepare methacrylic acid. | 11-27-2008 |
| 20080293969 | 18F-Labeled Daa Analogues and Method of Labeling These Analogues as Positron Emission Tomography (Pet) Tracers For Imaging Peripheral Benzodiazepine Receptors - Methods for selecting novel DAA analogues for a peripheral type benzodiazepine receptor were labeled with | 11-27-2008 |
| 20080293970 | Process for Synthesis of 4-4'-Diamino-Diphenyl-Sulfone - A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioeter intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity. | 11-27-2008 |
| 20080293971 | A Process for the Preparation of R-(-)-N, Alpha-Dimethylphenethylamine (Levmethamfetamine) or S-(+)-N, Alpha-Dimethylphenethylamine (Methamphetamine) from D-Ephendrine, or L-Ephedrine Respectively - A process for synthesis of R-(−)-N,α-Dimethylphenethylamine (Levmetamfetamine, formula I), or S-(+)-N,α-Dimethyl phenethylamine (Methamphetamine, formula II), from d-ephedrine of formula III or l-ephedrine formula IV, the process comprising the steps of (a) acylating the d- or l-ephedrine base of formula III or formula IV with an acylating agent to make a reaction mixture containing a N-acylated ephedrines of formula V or formula VI; (b) deoxygenation of N-acylated ephedrines to make the compound of the formula VII or Formula VIII by using Raney Nickel catalyst; and (c) acid hydrolysis of the above deoxygenated products to get the levmetamfetamine or methamphetamine. | 11-27-2008 |
| 20080293972 | Process for Preparing Substituted Anisidines - Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C | 11-27-2008 |
