48th week of 2008 patent applcation highlights part 41 |
Patent application number | Title | Published |
20080293077 | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses - The invention relates to the discovery and characterization of several genes and the polypeptides they encode: thymotaxin (Tango-45), Tango-63d, Tango-63e, Tango-67, and huchordin (Tango-66). Thymotaxin is a new member of the C-C family of chemokines. Tango-63d and Tango-63e are two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily. Tango-67 is related to a number of growth factors, particularly members of the connective tissue growth factor family. Huchordin is related to chordin, a known protein that is involved in the induction of twinned axes, can completely rescue axial development in ventralized embryos, is a potent dorsalizing factor, and plays a crucial role in regulating cell-cell interactions in the organizing centers of head, trunk, and tail development. The invention encompasses nucleic acid molecules encoding nucleic acids and polypeptides of the invention, or mutant forms thereof that encode dysfunctional receptor polypeptides, vectors containing these nucleic acid molecules, cells harboring recombinant DNA molecules encoding nucleic acids or polypeptides of the invention, or mutant forms thereof, host fusion proteins that include functional or dysfunctional polypeptides of the invention, transgenic animals that express nucleic acids or polypeptides of the invention, screening methods and therapeutic methods employing the nucleic acid molecules and polypeptides described above, substantially purified nucleic acids and polypeptides of the invention, and therapeutic compositions containing these nucleic acid molecules and polypeptides. | 2008-11-27 |
20080293078 | Method For the Detection of Atp in a Sample With the Aid of Luminescene and a Computer Programme For That Purpose - The present invention relates to a method for detecting ATP in a sample by using luminescence, wherein a luminescence reagent is added to the sample that has not undergone any pre-treatment with an extractant in order to effect the formation of an ATP complex, wherein the luminescence of the ATP com lex thus formed is measured. | 2008-11-27 |
20080293079 | Chip for Diagnosing the Presence of Candida - The present invention concerns means and methods of detection of | 2008-11-27 |
20080293080 | ACTIVE IMMUNIZATION USING A SIDEROPHORE RECEPTOR PROTEIN - The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis. | 2008-11-27 |
20080293081 | Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity - Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods involve fluorescence polarization measurements for determining the acetylation state of a substrate peptide. The methods may also be used to identify compounds that modulate the activity of a protein having acetyltransferase or deacetylase activity. Also provided are substrates for acetyltransferase or deacetylase enzymes for use in association with a fluorescence polarization assay. | 2008-11-27 |
20080293082 | INSTRUMENT - A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the biological fluid or control, which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component. The first and second measurements may be made sequentially or simultaneously. The method and apparatus then remove an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement. | 2008-11-27 |
20080293083 | Method and Kit for Peptide Analysis - The present invention relates to a method for peptide analysis, comprising the following steps: a) tagging N-terminals of peptides in sample(s) with mass tagging reagent(s) and mass balancing C-terminals of said peptides with mass balancing reagent(s), or vice versa; and b) mass spectrometry analysis of said peptides. The present invention also relates to a kit with global mass tagging reagents and mass balancing reagents for use in said method and a database with specific peptide information. | 2008-11-27 |
20080293084 | FLUORESCENCE POLARIZATION ASSAYS FOR DETERMINING CLOSTRIDIAL TOXIN ACTIVITY - The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin. | 2008-11-27 |
20080293085 | FLUORESCENCE POLARIZATION ASSAYS FOR DETERMINING CLOSTRIDIAL TOXIN ACTIVITY - The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage site that intervenes between the fluorophore and the bulking group; (b) exciting the fluorophore with plane polarized light; and (c) determining fluorescence polarization of the treated substrate relative to a control substrate, where a change in fluorescence polarization of the treated substrate as compared to fluorescence polarization of the control substrate is indicative of the presence or activity of the clostridial toxin. | 2008-11-27 |
20080293086 | REAL TIME MONITORING OF MICROBIAL ENZYMATIC PATHWAYS - This invention provides compositions and methods for monitoring and regulating the production of a target product of a biochemical pathway in an organism, such as butanol. A gene encoding a light-emitting reporter molecule, such as luciferase, is operatively linked with a transcription regulatory nucleotide sequence that regulates transcription of an enzyme in the pathway that signals the rate of production of the target product, such as butanol dehyrogenase. When a microorganism is transfected with such a reporter construct and cultured, the reporter is expressed contemporaneously with the enzyme. The amount of light produced by the reporter indicates amount of enzyme being produced which, in turn, signals the amount of target product being produced. When the reporter is measured in real time, it provides information that can be used to regulate culture conditions and to optimize production of the target product. | 2008-11-27 |
20080293087 | SULFONYLUREA RECEPTOR SHORT FORMS FROM MITOCHONDRIA AND USES THEREOF - The present invention relates to isolated sulfonylurea receptor polynucleotides and polypeptides, as well as vectors and cells lines containing the polynucleotides and polypeptides. The present invention also relates to methods of using cell lines containing the polynucleotides and polypeptides to identify agents that are useful in ischemic preconditioning. | 2008-11-27 |
20080293088 | Two-photon probe for real-time monitoring of intracellular magnesium ions, method for preparing the two-photon probe and method for real-time monitoring of intracellular magnesium ions using the two-photon probe - A two-photon probe for real-time monitoring of intracellular magnesium ions is provided. Specifically, the two-photon probe is represented by Formula 1: | 2008-11-27 |
20080293089 | Assays for Modulators of Parkin Activity Using Novel Substrates - The invention provides in vitro and cell-based assays for parkin activity, in which parkin-mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity. | 2008-11-27 |
20080293090 | AUTOMATED SEMI-SOLID MATRIX ASSAY AND LIQUID HANDLER APPARATUS FOR THE SAME - An improved liquid handling machine capable of regulating the temperature of assay compounds in the automated preparation of culture trays for biological assays is disclosed. The machine includes a horizontally movable table positioned beneath a vertically movable head. The table is divided into a plurality of stations holding mixing trays, culture trays and reservoirs of liquid assay compound. The head holds a plurality of pipettes which aspirate and expel liquid to transfer and mix the assay compounds between the reservoir, the mixing trays and the culture trays upon coordinated movement of the head and the table as controlled by a microprocessor. Each station on the table has independent heating, cooling and temperature sensing elements for regulating the temperature of the liquid held in a tray or reservoir at the station. A device for automatically evaluating the results of the assay, such as by fluorescence, spectrophotometric or radioactive techniques is incorporated with the improved liquid handling machine. | 2008-11-27 |
20080293091 | APPARATUS AND METHODS FOR AUTOMATED DIFFUSION FILTRATION, CULTURING AND PHOTOMETRIC DETECTION AND ENUMERATION OF MICROBIOLOGICAL PARAMETERS IN FLUID SAMPLES - A system providing non-intrusive, automated culturing and photometric detection for analyzing microbiological parameters is described. The system includes a sealed non-intrusive sample cuvette, a housing with an enclosable cover, systems for incubation and photometric detection mounted within the housing. The sample cuvette consists of a clear graduated optically transmitive container with two chambers—a culture chamber and a detection chamber, separated by a permeable membrane wall. The cuvette has an upper part and a lower part of different dimensions. The upper part is bigger in size than the lower part. The sealed top of the cuvette has two fluid inlet/outlet ports for the introduction of the sample into one chamber while when connected to a suitable vacuum device, the second chamber receives the filtered sample through the permeable membrane. The housing has a cuvette holder that is shaped to provide a very snug fit for the cuvette. When placed inside the cuvette holder the bottom of the upper part of the cuvette rests on top of the holder while the bottom part snugly fits inside the holder cavity. The housing with the enclosable cover provides a thermal chamber during simultaneous incubation and photometric enumeration of microbiological parameters. The cuvette holder accommodates a heating element and a temperature sensor. Photometric detection components comprising LEDs and detectors are placed strategically within the holder. | 2008-11-27 |
20080293092 | CALCIUM CHANNEL PROTEINS AND USES THEREOF - Described herein are compositions and uses thereof related to Ca | 2008-11-27 |
20080293093 | Determining presence of antibiotic in a fluid - A test system for the determination of the presence of an antibiotic in a fluid using Bromthymol Blue as an indicator. | 2008-11-27 |
20080293094 | Novel Enzymatic Substrates Derived from Phenoxazinone and Their Use as Developer in Detection of Microorganisms with Peptidase Activity - The invention concerns novel enzymatic substrates of the general formula below: | 2008-11-27 |
20080293095 | Polydiacetylene-Containing Solid Colorimetric and/or Fluorescent Detector, Method for Its Preparation and Uses Thereof - A colorimetric and/or fluorescent detector, which comprises a film of polydiacetylenes and lipids deposited on a substrate, wherein said film is coated with one or more layers, wherein at least one of said layers is capable of supporting the growth of microorganisms. Also provided are processes for preparing the novel colorimetric and/or fluorescent detector and uses thereof in the detection of bacteria. | 2008-11-27 |
20080293096 | Enzyme and Template-Controlled Synthesis of Silica from Non-Organic Silicon Compounds as Well as Aminosilanes and Silazanes and Use Thereof - The present invention relates to a method for synthesis of amorphous silicon dioxide (silica, condensation products of silicic acid) and other polymeric metal (IV) compounds from non-organic silicon compounds or metal (IV) compounds as well as from aminosilanes and silazanes, whereby (I) a template (collagen or another molecule, interacting with orthosilicic acid or polymeric silicic acid and salts thereof or other metal (IV) compounds) and (2) a silicase/carbonic anhydrase or a silicatein or similar polypeptide are used for synthesis. Said invention also relates to the technical use thereof. | 2008-11-27 |
20080293097 | Biological Production of Zeaxanthin and Carotenoid Biosynthesis Control - The present invention relates to the isolation of carotenoids and in particular the xanthophyll zeaxanthin (zeaxanthin-β,β-Carotene-3,3′-diol) and optionally other carotenoids such as lycopene, β,β-carotene, 3′-hydroxyechinenone β-cryptoxanthin and the colourless carotenoids, phytoene and phytofluene from a marine bacterium belonging to the genus | 2008-11-27 |
20080293098 | Dna Encoding Novel Enzyme Having D-Serine Synthase Activity, Method of Producing the Enzyme and Method of Producing D-Serine by Using the Same - This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme. | 2008-11-27 |
20080293099 | Lignan Glycosidase and Utilization of the Same - The present invention provides an enzyme having the lignan glycosidation activity by identifying the enzyme that is involved in the production of lignan glycosides, identifying the amino acid sequence of the enzyme polypeptide and the base sequence for a polynucleotide encoding the polypeptide, and based on the information of these sequences, preparing the transformants capable of producing the lignan glycosides. | 2008-11-27 |
20080293100 | Method for the Fermentative Production of L-Amino Acids With the Aid of Coryneform Bacteria Capable of Using Glycerin as the Only Carbon Source - The invention relates to a method for producing L-amino acids in which the following steps are carried out: a) the recombinant coryneform bacteria which produce the desired L-amino acid and in which at least one or several of the heterologous polynucleotides of the glycerol metabolism, selected among the group comprising glpA, glpB, glpC, glpD, glpE, glpF, glpG, glpK, glpQ, glpT, glpX, gldA, dhaK, dhaL, dhaM, dhaR, fsa, and talC, is/are expressed are cultivated in a medium containing glycerol or one or several other optional C sources in conditions in which the desired L-amino acid is enriched in the medium or the cells; and, optionally, b) the desired L-amino acid is isolated, all or fractions (>0 to 100 percent) of the components of the fermentation broth and/or biomass optionally remaining in the final product. In said method, bacteria are used in which other genes of the biosynthesis pathway of the desired L-amino acid are additionally reinforced or in which the metabolism pathways reducing the formation of the desired L-amino acid are eliminated at least in part. | 2008-11-27 |
20080293101 | Engineered microorganisms for increasing product yield in biotransformations, related methods and systems - There are disclosed recombinant microorganisms engineered to increase product yield in a biotransformation. In an embodiment, the microorganisms are engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. There are also disclosed methods and systems for using recombinant microorganisms engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. Other embodiments are also disclosed. | 2008-11-27 |
20080293102 | COMPOSITIONS AND METHODS FOR PRODUCING APOLIPOPROTEIN - The disclosure relates to recombinant nucleic acids, expression vectors comprising the recombinant nucleic acids, and host cells comprising the expression vectors for expressing a protein of interest. | 2008-11-27 |
20080293103 | STRESS PROTEIN COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF CANCER AND INFECTIOUS DISEASE - Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and | 2008-11-27 |
20080293104 | Proteases and Methods for Producing Them - A secreted mature polypeptide derived from an S2A or S1E protease which after maturation has protease activity, which polypeptide when expressed and before maturation comprises a heterologous pro-region. | 2008-11-27 |
20080293105 | Recombinant method for making multimeric proteins - The present invention relates to methods for making multimeric proteins comprising fusion of two or more cells expressing a single subunit of the multimeric protein to generate a single hybrid cell expressing the fully assembled multimeric protein. | 2008-11-27 |
20080293106 | Method For the Mass Production of Immunoglobulin Fc Region Deleted Initial Methionine Residues - Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising an immunoglobulin Fc region linked at the N-terminus thereof to an immunoglobulin Fc region via a peptide bond. | 2008-11-27 |
20080293107 | METHODS FOR USING RIBOPRIMERS FOR STRAND DISPLACEMENT REPLICATION OF TARGET SEQUENCES - Methods, compositions and kits for amplifying a target sequence by strand displacement replication using strand-displacing primers. The method uses primers that have only ribonucleotides or purine ribonucleotides and at least one 2′-substituted pyrimidine-2′-deoxyribonucleotide. | 2008-11-27 |
20080293108 | Hyaluronate synthase gene and uses thereof - Disclosed are DNA sequences encoding hyaluronic acid synthase that are employed to construct recombinant cells useful in the production of hyaluronata synthase and hyaluronic acid (HA). In preferred aspects, chromosomal DNA encoding the HA synthase gene, hasA, was cloned from a | 2008-11-27 |
20080293109 | Methods for degrading or converting plant cell wall polysaccharides - The present invention relates to methods for converting plant cell wall polysaccharides into one or more products, comprising: treating the plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes which degrade or convert the plant cell wall polysaccharides into the one or more products. The present invention also relates to methods for producing an organic substance, comprising: (a) saccharifying plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes which degrade or convert the plant cell wall polysaccharides into saccharified material; (b) fermenting the saccharified material of step (a) with one or more fermenting microoganisms; and (c) recovering the organic substance from the fermentation. | 2008-11-27 |
20080293110 | Process for Isolation of Mycophenolic Acid - Mycophenolic acid can be isolated from fermentation broth easily with low consumption or organic solvents to produce mycophenolic acid that is surprisingly high in purity. The process can be accomplished by addition of a suitable base to the whole fermentation broth. i.e., a suspension obtained by submerged cultivation of a microorganism producing mycophenolic acid, to increase pH of the liquid phase to the value from about (9) to about (13). Mycophenolic acid is thus extracted from the mycelium to the liquid phase and the exhausted mycelium can be separated easily by filtration. | 2008-11-27 |
20080293111 | Process for the Enzymatic Preparation of Citronellal - A process for preparing optically active saturated aldehydes or alcohols of the formula (2) from α,β-unsaturated aldehydes of the formula (1) by reduction in the presence of an enoate reductase
| 2008-11-27 |
20080293112 | SUCCINIC ACID-PRODUCING BACTERIUM AND PROCESS FOR PRODUCING SUCCINIC ACID - Coryneform bacterium is modified so that an activity of acetyl-CoA hydrolase is decreased, and succinic acid is produced by using the bacterium. | 2008-11-27 |
20080293113 | PROCESS FOR PRODUCTION OF SUCCINIC ACID - Disclosed is a process for production of succinic acid, which comprises the step of reacting a bacterium which has been modified so as to increase the expression of a sucE1 gene or a product produced by any treatment of the bacterium with an organic raw material in a reaction solution containing a carbonate ion, a bicarbonate ion or carbon dioxide gas to thereby yield the desired succinic acid. | 2008-11-27 |
20080293114 | Method of Continuous Processing of Lignocellulosic Feedstock - A continuous process for treating a lignocellulosic feedstock is provided. This method comprises pretreating the lignocellulosic feedstock under pressure in a pretreatment reactor at a pH between about 0.4 and about 2.0. One or more than one soluble base is added to this pressurized, pretreated feedstock after it exits the pretreatment reactor to adjust the pretreated lignocellulosic feedstock to an intermediate pH of between about pH 2.5 to about pH 3.5. This pressurized, partially-neutralized feedstock is then further processed at the intermediate pH. This may include flashing one or more than one time at the intermediate pH. The pH of the pressurized, partially-neutralized feedstock may then be adjusted with one or more than one base to produce a neutralized feedstock having a pH between about 4 and about 6. Prior to adjusting the pH to between about 2.5 and about 3.5, the pressurized, pretreated feedstock may be partially depressurized. | 2008-11-27 |
20080293115 | PLANT WALL DEGRADATIVE COMPOUNDS AND SYSTEMS - The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications. | 2008-11-27 |
20080293116 | OVARY-SPECIFIC GENES AND PROTEINS - Ovary specific proteins O1 180, O1 184 and O1 236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1 180, O1 184 or O1 236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which are associated with O1 180, O1 184 or O1 236. Further provided are methods for the evaluation of potential contraceptives using the proteins of the invention, as well as methods for the screening for genetic mutations in signaling pathways that are associated with some forms of human infertility or gynecological cancers, also using the proteins/mRNAs/genes of the invention. The proteins/mRNAs/genes of the invention may also be used as markers for identifying primary and metastatic neoplasms of ovarian origin and as indicators of developmental anomalies in prenatal screening procedures. Furthermore, assays of the proteins/mRNAs/genes of the invention can be used in diagnostic assays for detecting forms of infertility and other diseases, including germ cell tumors and polycystic ovary syndrome. The proteins of the invention may be useful targets for in vitro fertilization procedures or in enhancing the number of eggs that can be retrieved from the human donor, e.g., in enhancing the success rate. | 2008-11-27 |
20080293117 | HEAT RESISTANT BIOACTIVE COMPOSITION - A bioactive composition includes a hydrogel matrix. At least one protein is immobilized in the hydrogel matrix. The digestive protein has a half-life at least 1000 times longer than the half-life of a free digestive protein counterpart. | 2008-11-27 |
20080293118 | Magnetic fine particles having lower critical solution temperature - The present invention relates to magnetic fine particles having a lower critical solution temperature to which at least one substance selected from biotin and avidin is immobilized, and a method of converting a substance, a method of separating or concentrating a microorganism, a method of modifying a denatured protein, a method of detecting a nucleic acid, a separating agent, and a method of separating a biological substance using the same. | 2008-11-27 |
20080293119 | B12 DEPENDENT DEHYDRATASES WITH IMPROVED REACTION KINETICS - Sequences of B | 2008-11-27 |
20080293120 | LIPOLYTIC ENZYMES VARIANTS - The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough stickiness when they are added to a dough. The polypeptides may particularly have activity on polar lipids. | 2008-11-27 |
20080293121 | HUMAN DNASE I HYPERACTIVE VARIANTS - The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of hyperactive variants of human DNase I. | 2008-11-27 |
20080293122 | Method for Activating Prethrombin-1 - Methods for converting prethrombin-1 to thrombin are disclosed. An aqueous solution of prethrombin-1 is applied to oscutarin-C immobilized on a solid support so as to provide from 500 mg to 4000 mg of prethrombin-1 per mL of the solid support and a contact time between the prethrombin-1 and the oscutarin-C of from 1.8 to 3.5 minutes. The resulting active thrombin may be captured on an ion exchange chromatography medium or an affinity chromatography medium. | 2008-11-27 |
20080293123 | COMPOSITIONS COMPRISING VIRUSES AND METHODS FOR CONCENTRATING VIRUS PREPARATIONS - A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed. | 2008-11-27 |
20080293124 | Multimeric Oxidoreductases - The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof. | 2008-11-27 |
20080293125 | ENGINEERED MICROORGANISMS FOR PRODUCING ISOPROPANOL - In an embodiment, there is disclosed a recombinant microbial host cell having each of the DNA molecules encoding a polypeptide or group of polypeptides that catalyze the conversion: | 2008-11-27 |
20080293126 | Novel Lactobacillus Living Body Activating Lactobacillus Preparation and Preventive or Therapeutic Agent for Living Body Infection - There has been effort to develop a | 2008-11-27 |
20080293127 | Method to Render Pressure Sensitive Adhesive Compatible with Polymerase Chain Reaction Systems - A method for substantially eliminating a cross-linking element of a pressure sensitive adhesive by heating the pressure sensitive adhesive at a temperature of at least 180° C. for a period of time required to thermally decompose the cross-linking element of the pressure sensitive adhesive. | 2008-11-27 |
20080293128 | SENSOR OF PYROPHOSPHATE AND SNP TYPING SENSOR USING THE SAME - A sensor of pyrophosphate which can detect pyrophosphate conveniently with high sensitivity in a method for measuring pyrophosphate in SNP typing utilizing a primer extension reaction is provided. | 2008-11-27 |
20080293129 | Fluid Handling Unit and Fluid Handling Apparatus Using Same - A fluid handling unit | 2008-11-27 |
20080293130 | BIOCHIP - A biochip that can make optical measurements without being affected by background fluorescence etc., originating from the outside environment, wherein the surface of the substrate of the biochip can be chemically treated by a simple procedure. The biochip has at least a nontransparent resin substrate, an immobilizing layer formed on a part of the non-transparent resin substrate, and an organic molecule immobilized on the immobilizing layer, and detects an analyte labeled with fluorescence or luminescence in a sample, from the intensity of the fluorescence or luminescence. | 2008-11-27 |
20080293131 | Culture observation equipment - The present application includes a culture chamber, an observation chamber having an optical system of observation to observe samples to be cultured in the culture chamber, and a movement stage provided at a boundary which separates the culture chamber and the observation chamber, functioning as a wall to maintain an environment of both of the chambers, bearing the samples, and moving the samples on a light axis of observation of the optical system of observation. Due to such an arrangement, a culture observation equipment which has good response and excellent environmental resistance can be achieved, preventing problems such as the overall size of the device became large, maintenance work was difficult, and device cost became expensive. | 2008-11-27 |
20080293132 | High Density Bioreactor System, Devices, and Methods - A bioreactor and bioreactor system are suitable for the growth of materials from algae. More specifically, the system preferred embodiments use concentrated sunlight in a solo- or co-generation system to produce algae and products therefrom as well as solar thermal energy. | 2008-11-27 |
20080293133 | Textiles for use in bioreactors for expansion and maintenance of cells - A bioreactor for three-dimensional culture of liver cells is disclosed. The device is characterized by the use of textile vasculatures. A model and method for optimizing vasculature parameters is also disclosed. Liver acinar structure and physiological parameters are mimicked by sandwiching cells in the space between the two innermost woven textile hollow fibers, and creating radial flow of media from an outer compartment, through the cell mass compartment, and to an inner compartment. The theoretical optimum hydraulic permeability for the two innermost semi-permeable membranes is determined based on physiological hepatic sinusoidal blood flow and pressures. Experimental studies using a flow rate and pressure monitoring systems in conjunction with phase-contrast velocity-encoded MRI confirm theoretical results. Novel woven vascular tubes with optimum hydraulic permeability are disclosed for culturing hepatocytes in the multi-coaxial bioreactor. | 2008-11-27 |
20080293134 | Human Cancer Suppressor Gene, Protein Encoded Therein, Expression Vector Containing Same - Disclosed are a human cancer suppressor gene, a proteins encoded therein, an expression vectors containing the same, and a microorganism transformed with the vector. The genes of the present invention may be useful to diagnose and prevent the human cancers. | 2008-11-27 |
20080293135 | Co-Culture Bioreactor System - Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers ( | 2008-11-27 |
20080293136 | NUCLEIC ACID COMPOUNDS FOR INHIBITING AKT GENE EXPRESSION AND USES THEREOF - The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing AKT gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to an AKT mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine, a nucleoside replaced with a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of an AKT gene in a cell or in a subject to treat an AKT-related disease. | 2008-11-27 |
20080293137 | COMPOUNDS THAT ABROGATE DNA DAMAGE INDUCED CELL CYCLE G2 CHECKPOINT AND/OR AUGMENT ANTI-CANCER ACTIVITY OF DNA-DAMAGING TREATMENTS - The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments. | 2008-11-27 |
20080293138 | BIOLOGICALLY ACTIVE SUBSTANCE TRANSFER SHEET, CELL CULTURE KIT CONSTITUTED OF CELL CULTURE PLATE AND BIOLOGICALLY ACTIVE SUBSTANCE TRANSFER SHEET, PRODUCING METHOD THEREOF AND METHOD FOR SCREENING CELL CULTURE CONDITIONS UTILIZING THE SAME - The invention provides a biologically active substance transfer sheet which can be formed with simple steps, a cell culture kit which comprises a cell culture plate and a biologically active substance transfer sheet, a producing method therefor, and a method for screening cell culture conditions with cells. The transfer sheet is prepared by providing biologically active substances having biological activity in plural areas on a sheet base, and biologically active substances are supplied from the sheet to culture regions provided on the plate. | 2008-11-27 |
20080293139 | CELL CULTURE SUPPORT FOR FORMING STRING-SHAPED CARDIOMYOCYTE AGGREGATES - This invention is intended to provide cell aggregates that can reproduce functions of the myocardium, such as the function of beating, and thus are available for myocardial regenerative therapy, and to provide a cell culture support for producing the same. | 2008-11-27 |
20080293140 | PROPAGATION AND/OR DERIVATION OF EMBRYONIC STEM CELLS - Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered. Instead, the compound inhibits a signalling pathway which is essential for propagation of differentiated cells but is not essential for propagation of ES cells—hence ES cells are selectively maintained in the culture. | 2008-11-27 |
20080293141 | Cell for Producing Retrovirus Vector - The N-acetylglucosaminyltransferase III activity is enhanced in a cell carrying retrovirus-origin gag-pol gene and env gene. By constructing a retrovirus vector with the use of the above cell, a retrovirus vector having a modified sugar chain structure can be obtained. The retrovirus vector constructed by this method shows a high infection efficiency particularly in the presence of a functional substance. | 2008-11-27 |
20080293142 | Multiple shRNA Expression Vectors and Methods of Construction - A research or therapeutic tool for RNA interference (RNAi) is a single vector that expresses multiple short hairpin RNA (shRNA) sequences. | 2008-11-27 |
20080293143 | Generation of human embryonc stem-like cells using intronic RNA - This invention generally relates to a method for developing, generating and selecting human embryonic stem (hES)-like pluripotent cells using transgenic expression of intronic microRNA-like RNA agents. More particularly, the present invention relates to a method and composition for generating a non-naturally occurring intron and its intronic components capable of being processed into mir-302-like RNA molecules in mammalian cells and thus inducing certain specific gene silencing effects on differentiation-related and fate-determinant genes of the cells, resulting in reprogramming the cells into a pluripotent embryonic stem (ES)-cell-like state. The ES-like cells so obtained are strongly express hES cell markers, such as Oct3/4, SSEA-3 and SSEA-4, and can be guided into various tissue cell types by treating certain hormones and/or growth factors under a feeder-free cell culture condition in vitro, which may be used for transplantation and gene therapies. Therefore, the present invention offers a simple, effective and safe gene manipulation approach for not only reprogramming somatic cells into ES-like pluripotent cells but also facilitating the maintenance of pluripotent and renewal properties of ES cells under a feeder-free cell culture condition, preventing the tedious retroviral insertion of four large transcription factor genes into one single cell as used in the previous iPS methods. | 2008-11-27 |
20080293144 | FIVE-PART DIFFERENTIAL WHITE BLOOD CELL CONTROL AND METHOD FOR PREPARATION OF THE SAME - The present invention provides a method for preparing a five-part differential white blood cell control and a white blood cell control prepared thereby. The white blood cell control obtained by the method of the present invention perfectly retains the light scattering properties of every type of white blood cells and has much higher stability than that of real white blood cells, and therefore can be used for the quality control of five-part differential hematology analyzers based on the principle of multi-angle light scattering. | 2008-11-27 |
20080293145 | SINGLE POPULATION OF SIMULATED LEUKOCYTE GRANULES, CALIBRATORS COMPRISING THE SAME AND METHODS OF PREPARING THE SAME - The present invention discloses a single population of simulated leukocyte granules prepared from mammalian whole white blood cells, which is useful in calibrators for a hematology analyzer, a calibrator comprising the single population of simulated leukocyte granules, and a method of preparing the single population of simulated leukocyte granules. The method of preparing single population of simulated leukocyte granules according to present invention comprises the steps of: obtaining mammalian whole white blood cells; treating the mammalian whole white blood cells under the action of a hemolytic agent in the presence of a leukocyte treating liquid, i.e., an isotonic saline solution comprising a fixative, a oxidizer and a carbohydrate; fixing the treated mammalian whole white blood cells with a fixative; and suspending the fixed cells in a preservation medium suitable for long-term preservation of fixed cells. | 2008-11-27 |
20080293146 | Method And Apparatus For Compensating For Variations In Particle Trajectories In Electrostatic Sorter For Flowcell Cytometer - A flow cytometer subsystems monitors a particle sensing zone within a fluid transport chamber for the presence of a particle (e.g., blood cell) traveling therethrough, and produces an output pulse, whose width is representative of the trajectory and thereby the length of time that the particle is within the particle sensing zone as it travels through the fluid transport chamber. This output pulse is then processed in accordance with geometry parameters of successive time delay zones of the particle fluid transport chamber through which the particle passes, in order to derive a composite time delay between the sensing of the particle to the time at which a fluid droplet containing the particle will break off from the carrier fluid. The composite time delay is employed to accurately establish the time at which the particle is controllably charged as the particle breaks off from the carrier fluid. | 2008-11-27 |
20080293147 | Method of Detecting Structural Change in Target Sugar Chain - A method of easily and efficiently detecting any structural change in a target sugar chain that can be present as a first or a second sugar chain depending on the structural change. In the method, the target sugar chain is mixed with a first to an n | 2008-11-27 |
20080293148 | Method and System for Detecting Bio-Element - Disclosed are system and method for measuring a bio-element capable of accurately detecting whether a bio-element such as protein, gene and the like is present in an atmosphere or vapor phase having controlled temperature and humidity thereof and measuring a content of the bio-element. According to an embodiment of the invention, the method comprises steps of preparing a cantilever sensor having a plurality of cantilevers; measuring a basis resonant frequency for the plurality of cantilevers; reacting the cantilevers with a sample including a bio-element; measuring resonant frequencies of the cantilevers after the reaction, in a closed system that is isolated from an exterior environment and temperature and humidity thereof are controlled to a specific state; and calculating variations of the resonant frequencies of the cantilevers before and after the reaction to carry out a quantitative analysis of the bio-element included in the sample. | 2008-11-27 |
20080293149 | ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate. | 2008-11-27 |
20080293150 | Nmr Signal Assignment Method - It is an object of the present invention to provide a method of efficiently and rapidly determining the assignment of signals obtained by the | 2008-11-27 |
20080293151 | FIBER-PACKED NEEDLE FOR ANALYZING ALDEHYDES/KETONES, ANALYTICAL APPARATUS AND ANALYTICAL METHOD - Provided are a simple method for analyzing aldehydes and ketones in a sample, which does not require a complicated operation such as extraction with a solvent and concentration of the extract; and an analytical apparatus and a fiber-packed needle which are used in the analytical method. Also provided a fiber coated with hydrochloride or sulfate of 2,4-dinitrophenylhydrazine; a needle for microextraction in which the fibers are packed; the analytical apparatus including this needle and a suction device; the method for analyzing aldehydes and ketones in a sample, characterized by comprising sucking the sample through the needle in this analytical apparatus to allow the aldehydes and ketones in the sample to react with 2,4-dinitrophenylhydrazine, thereby converting them to the corresponding 2,4-dinitrophenylhydrazones; desorbing the 2,4-dinitrophenylhydrazones; and introducing the desorbed 2,4-dinitrophenylhydrazones into a chromatograph to analyze them. | 2008-11-27 |
20080293152 | NANOMEMBRANES FOR REMOTE SENSING - The present invention provides sensors for use in detecting the presence or absence of analytes, systems incorporating the sensors, and methods for using the sensors. The sensors include thin membranes that undergo a detectable geometry change upon exposure to an analyte. In one exemplary embodiment, the sensors are small, thin-film membranes that include a stained semiconductor bilayer, wherein an interaction between the membrane and an analyte induces a detectable change in a strain-induced curvature of the membrane. | 2008-11-27 |
20080293153 | Photolabile System with Instantaneous Fluorescence Reporting Function - A method of photofragmentation is provided comprising: providing a masked fluorescent molecule having a masking group bonded to a fluorescent molecule through a photolabile covalent bond; exposing the masked fluorescent molecule to cleaving photoradiation, producing an unmasked fluorescent molecule; detecting the fluorescence of the unmasked fluorescent molecule. The photolabile covalent bond disrupts the conjugation of the fluorescent molecule, causing the fluorescence to be masked. When the photolabile covalent bond is broken, the conjugation is restored, resulting in an increase in fluorescence of the fluorescent molecule as compared to the masked fluorescent molecule. | 2008-11-27 |
20080293154 | Apparatus and method for detecting target - The target detecting apparatus includes: a first container having a metal inside and containing a fluorescent particle which generates fluorescence on exposure to light and quenches the fluorescence on contacting the metal; a second container having the metal inside and containing a target sample that contains at least the fluorescent particle therein; a centrifugal force giving unit configured to allow the fluorescent particles to be in contact with the metal by giving a centrifugal force to the first container and the second container; a light irradiation unit configured to expose the fluorescent particle contained in each of the first container and the second container to light; and a fluorescence detecting unit configured to detect an intensity of fluorescence generated by the fluorescent particle upon exposure to light from the light irradiation unit. | 2008-11-27 |
20080293155 | SALICYLAMIDE-LANTHANIDE COMPLEXES FOR USE AS LUMINESCENT MARKERS - The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention. | 2008-11-27 |
20080293156 | DEVICES AND METHODS FOR DISPENSING REAGENTS INTO SAMPLES - Devices and methods of dispensing and mixing reagents with samples in an enclosed container in which the amounts of the reagents dispensed into the sample are predetermined. The devices include dispensing covers attached to a funnel that feeds into a sample chamber. The dispensing covers may contain off-axis dispensing chambers that are sealed and that can be opened and any reagent(s) located therein dispensed into the at selected times. The off-axis dispensing chambers are preferably offset from a main axis of the device, such that the reagents dispensed from the dispensing chambers fall, under the force of gravity, onto the funnel wall and are then directed into the sample chamber. | 2008-11-27 |
20080293157 | Apparatus and method of performing high-throughput cell-culture studies on biomaterials - In one embodiment, a kit includes a base and a specimen removably couplable to the base. A top plate defines a plurality of apertures and is removably couplable to the base such that at least two of the apertures are associated with a specimen and each aperture defines a well with that specimen. Each well is configured to receive a sample material therein in contact with the specimen. A method includes disposing a specimen within a recessed portion of a test apparatus and coupling a top plate of the test apparatus to a base of the test apparatus such that a sealing engagement is formed between the top plate and the specimen. The top plate defines a plurality of apertures, each of at least two of the apertures collectively with the specimen defines a well. A sample material can be disposed within at least one well. | 2008-11-27 |
20080293158 | Method And Apparatus For Improved Gas Detection - The invention relates to a method and apparatus for providing a reactor having a heater, a passage for transporting a reactant, and a chamber containing a gas sample and being coupled to the passage for receiving the reactant and mixing the reactant with the gas sample. The reactor further includes a connector leading from the chamber to the heater for transporting a mixture of the reactant and gas sample, and wherein the heater heats the mixture of the reactant and gas sample. | 2008-11-27 |
20080293159 | Validation Process - The present invention provides a process for validating the efficacy of a sample having a known activity determined using a biological assay. The process includes subjecting the sample to a biological assay capable of testing for the activity. The process may optionally include an initial step of determining a biological assay for the desired activity. The present invention is particularly applicable to samples from milk. | 2008-11-27 |
20080293160 | DNA AND RNA CONFORMATIONAL SWITCHES AS SENSITIVE ELECTRONIC SENSORS OF ANALYTES - The electrical conductivity of DNA and other oligonucleotide constructs is dependent on its conformational state. Such a dependence may be harnessed for the electronic sensing of external analytes, for instance, adenosine or thrombin. Such a DNA sensor incorporates an analyte receptor, whose altered conformation in the presence of bound analyte switches the conformation, and hence, the conductive path between two oligonucleotide stems, such as double-helical DNA. Two distinct designs for such sensors are described that permit significant electrical conduction through a first or “detector” double-helical stem only in the presence of the bound analyte. In the first design, current flows through the analyte receptor itself whereas, in the second, current flows in a path adjacent to the receptor. The former design may be especially suitable for certain categories of analytes, including heterocycle-containing compounds such as adenosine, whereas the latter design should be generally applicable to the detection of any molecular analyte, large or small, such as the protein thrombin. Since analyte detection in these DNA sensors is electronic, the sensors may be used in rapid and automated chip-based detection of small molecules as well as of proteins and other macromolecules. | 2008-11-27 |
20080293161 | Detection of Carbohydrate Biomarkers - The present invention generally relates to detection of carbohydrate biomarkers in nipple aspirate fluid samples. One aspect of the invention is a method for assaying a nipple aspirate fluid for the presence of TF or Tn carbohydrate biomarker. The assay generally employs an immobilized capture agent specific for TF or Tn and can be further coupled to either direct or indirect detection of bound TF or Tn carbohydrate biomarker through the use of a labeled binding agent. | 2008-11-27 |
20080293162 | Methods and compositions for diagnosing neoplastic disease - Methods and compositions for determining whether a subject at least has a neoplastic disease are provided. In practicing the subject methods, a sample from a subject is assayed for a soluble filamin analyte, such as a filamin A analyte, to determine whether the subject at least has the neoplastic disease. Also provided are kits, systems, and devices for practicing the subject methods. | 2008-11-27 |
20080293163 | Methods to identify compounds that modulate rage - Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE ligand onto a solid surface; adding a compound of interest and a protein comprising RAGE or fragment thereof, to the preadsorbed ligand; adding an antibody which binds to RAGE or fragment thereof and a secondary antibody which binds to the anti-RAGE antibody; measuring the secondary antibody bound to the anti-RAGE antibody; and comparing the amount of RAGE bound to the ligand in the presence of varying amounts of the compound of interest. In an embodiment, the fragment of RAGE is sRAGE. In one aspect, the invention use of compounds detected by the method for treatment of AGE-related syndromes including complications associated with diabetes, kidney failure, lupus nephritis or inflammatory lupus nephritis, amyloidoses, Alzheimer's disease, cancer, inflammation, and erectile dysfunction. | 2008-11-27 |
20080293164 | Fluorescent Methods and Materials for Directed Biomarker Signal Amplification - Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule. | 2008-11-27 |
20080293165 | METHOD FOR MANUFACTURING NON-VOLATILE MAGNETIC MEMORY - In accordance with a method of the present invention, a method of manufacturing a magnetic random access memory (MRAM) cell and a corresponding structure thereof are disclosed to include a multi-stage manufacturing process. The multi-stage manufacturing process includes performing a front end on-line (FEOL) stage to manufacture logic and non-magnetic portions of the memory cell by forming an intermediate interlayer dielectric (ILD) layer, forming intermediate metal pillars embedded in the intermediate ILD layer, depositing a conductive metal cap on top of the intermediate ILD layer and the metal pillars, performing magnetic fabrication stage to make a magnetic material portion of the memory cell being manufactured, and performing back end on-line (BEOL) stage to make metal and contacts of the memory cell being manufactured. | 2008-11-27 |
20080293166 | LASER PROCESSING OF LIGHT REFLECTIVE MULTILAYER TARGET STRUCTURE - A solution to an interference effect problem associated with laser processing of target structures entails adjusting laser pulse energy or other laser beam parameter, such as laser pulse temporal shape, based on light reflection information of the target structure and passivation layers stacked across a wafer surface or among multiple wafers in a group of wafers. Laser beam reflection measurements on a target link measurement structure and in a neighboring passivation layer area unoccupied by a link enable calculation of the laser pulse energy adjustment for a more consistent processing result without causing damage to the wafer. For thin film trimming on a wafer, similar reflection measurement information of the laser beam incident on the thin film structure and the passivation layer structure with no thin film present can also deliver the needed information for laser parameter selection to ensure better processing quality. | 2008-11-27 |
20080293167 | FABRICATION METHOD OF SEMICONDUCTOR INTEGRATED CIRCUIT DEVICE - A memory test is carried out on semiconductor integrated circuit devices including a semiconductor memory at low cost with efficiency. In a test burn-in system, twenty-four test boards are processed in sequence with time differences, and the test boards are circulated one by one. In this case, the memory test is conducted with the sequence of single board processing: the test is started with a test board in which semiconductor integrated circuit devices have been embedded, and semiconductor integrated circuit devices are discharged, beginning with a test board that has undergone the test. | 2008-11-27 |
20080293168 | Method and system of tape automated bonding - A tape automated bonding (TAB) structure which includes a flex tape having a conductive lead pattern formed thereon. The conductive lead pattern includes a plurality of leads configured to form an inner lead bond (ILB) portion of the TAB structure. At least one of the plurality of leads is internally routed and has a contact exposed interior to the ILB portion of the TAB structure. | 2008-11-27 |
20080293169 | LITHOGRAPHY EVALUATING METHOD, SEMICONDUCTOR DEVICE MANUFACTURING METHOD AND PROGRAM MEDIUM - A lithography evaluating method comprises preparing a substrate, the substrate including a semiconductor substrate and a wiring structure including at least one wiring layer formed on the semiconductor substrate, partitioning the substrate into a plurality of regions to be evaluated, and obtaining a value of property relating to the wiring structure previously, and evaluating proximity effect on each of the plurality of regions to be evaluated based on the value of the property relating to the wiring structure. | 2008-11-27 |
20080293170 | METHOD FOR EVALUATING A GATE INSULATION FILM CHARACTERISTIC FOR USE IN A SEMICONDUCTOR DEVICE - A gate insulating film | 2008-11-27 |
20080293171 | LIGHT EMITTING DIODES (LEDs) WITH IMPROVED LIGHT EXTRACTION BY ROUGHENING - Systems and methods are disclosed for fabricating a semiconductor light emitting diode (LED) device by forming an n-gallium nitride (n-GaN) layer on the LED device and roughening the surface of the n-GaN layer to extract light from an interior of the LED device. | 2008-11-27 |
20080293172 | Method for manufacturing light emitting diode devices - A method for manufacturing LED devices is disclosed to manufacture vertical LED devices without removing nonconductive substrates. A conductive substrate is formed on the LED epitaxial layer of the nonconductive substrate to form a LED wafer by bonding or electroplating, which is further cut into a plurality of LED sticks with each space layer bonded between every two LED sticks. Secondly, the plurality of LED sticks and space layers are fixed by a fixture while type I semiconductor layer and active layer of the LED epitaxial layer of each LED stick are covered by each space layer. A transparent conductive layer is further formed thereon whereby to electrically connect with the type II semiconductor layer contrary to type I and are further formed with a plurality of electrodes thereon. Finally the said LED sticks are cut to a plurality of LED devices. | 2008-11-27 |
20080293173 | White Multi-Wavelength LED and Its Manufacturing Process - A white multi-wavelength LED and its manufacturing process has bonded at the bottom of a light emitting chip in a given color a first non-conductive material containing phosphor in a corresponding color to that of the chip to become a die unit; the first non-conductive material functioning as the position where the die unit is bonded to a carrier; golden plated wire constituting the circuit connection of the chip; a second non-conductive material containing phosphor in a color corresponding to that of the chip being injected to cover up the top of the chip to emit the expected white light and effectively promote the luminance performance of the LED. | 2008-11-27 |
20080293174 | Method for forming LED array - A method for forming LED array is disclosed herein. First, a LED wafer, a substrate having a LED epitaxial layer thereon, is cut into a plurality of LED sticks. Then, each space layer is bonded between every two LED sticks to form a LED array. | 2008-11-27 |
20080293175 | METHOD FOR MOUNTING ANISOTROPICALLY-SHAPED MEMBERS - A mounting method of the present invention includes the steps of: (I) disposing a first liquid in a first region provided on one principal surface of a substrate; (II) bringing a pillar-like member as an anisotropically-shaped member, disposed on one principal surface of a transfer substrate in a predetermined orientation, into contact with the first liquid disposed in the first region, so as to move the pillar-like member to a region of the first liquid; and (III) removing the first liquid from the substrate. | 2008-11-27 |
20080293176 | METHOD FOR MANUFACTURING SEMICONDUCTOR OPTICAL DEVICE - A method for manufacturing a semiconductor optical device includes: forming a first resist pattern on top surface of a laminated semiconductor structure; forming channels and a waveguide ridge by dry etching using the first resist pattern as a mask; forming an SiO | 2008-11-27 |