45th week of 2012 patent applcation highlights part 37 |
Patent application number | Title | Published |
20120282568 | SELF-REGULATING FLUID DISPENSING CAP SYSTEM AND METHOD OF USE - A cap system for connecting a fluid container to a self-contained dental water supply system of a dental work station comprising of a cap that attaches to an open end of a fluid container, a cap holder comprising a manifold and a manifold holder, the manifold connects to the self-contained dental water supply system and to the cap, the manifold moving within the manifold holder when the fluid in the fluid container reaches a certain amount to cause the self-contained dental water supply issue an alarm, the manifold further comprising a gas pressure regulator to convert high pressure gas of the self-contained dental water supply system to low pressure gas to move liquid from the liquid container through the manifold into self-contained dental water supply system, the high pressure gas pushes a sealing plunger in the manifold upon the cap to connect the manifold to fluid container. | 2012-11-08 |
20120282569 | FILLING STATION FOR SELF-CONTAINED DENTAL WATER SUPPLY SYSTEMS AND METHOD OF USE - One possible embodiment of the invention could a filling station for fluid containers used in self-contained dental water supply systems comprising at least one pressurized fluid supply; at least one low pressure gas supply; the first valve circuit continuously connecting to the at least one pressurized fluid supply; the second valve circuit continuously connecting to the at least one low pressurized gas supply; the manifold that continuously connects to first and second valve circuits; a cap that attaches to a fluid container used in self-contained dental water supply system, the cap reversibly and continuously connects an interior of the fluid container to the manifold; an electronic control unit utilizing one or more timer circuits, wherein each timer circuit operates its respective valve circuit for a predetermined amount of time to deliver a predetermined amount of gas or fluid at a predetermined pressure into the interior of the fluid container. | 2012-11-08 |
20120282570 | Toothcleaning Device - Equipment for daily dental care: teeth are cleaned by water jet with admixed softly abrasive media for the dissolution of plaques. A particular mixing chamber for the transfer of the ingredients from tabs may be branched either to by passes on faucets or showering mixing taps or to hereditary water jet pumping systems. Pressure and spray characteristics of the jet can be adjusted with a spiral nozzle. | 2012-11-08 |
20120282571 | ENDODONTIC INSTRUMENTS AND METHODS OF MANUFACTURING THEREOF - A method for manufacturing a nonlinear superelastic file comprising the steps of: providing a superelastic file having a shaft and a file axis; providing a fixture including a file groove being defined by one or more displacement members, the file groove configured for receiving the shaft; inserting at least a portion of the shaft into the fixture along the file groove, the portion of the shaft including a first portion of the shaft; contacting the first portion of the shaft with a first displacement member of the one or more displacement members such that the first portion of the shaft is displaced from the file axis thereby forming a first offset portion of the shaft; heating the portion of the shaft while inserted in the fixture to a temperature of at least about 300° C. for a time period of at least about 1 minute to shape-set the portion of the shaft thereby forming a shape-set nonlinear file. | 2012-11-08 |
20120282572 | Methods, Apparatuses, Computer Programs, and Systems for Creating a Custom Dental Prosthetic Using CAD/CAM Dentistry - A procedure for creating a dental prosthetic includes registering three-dimensional (3D) dental impression image data of a tooth restoration site and 3D x-ray image data of the tooth restoration site, and removing image data corresponding to soft tissue in the tooth restoration site from the 3D dental impression image data. A system for producing a dental prosthetic includes at least one processor operable to register 3D dental impression image data of a tooth restoration site and 3D x-ray image data of the tooth restoration site and remove image data corresponding to soft tissue in the tooth restoration site from the 3D dental impression image data. | 2012-11-08 |
20120282573 | TOOTH SCAFFOLDS - Provided is an acellular mammalian tooth-shaped scaffold comprising a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting an acellular scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing an acellular scaffold in the shape of a mammalian tooth and adding at least one compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. | 2012-11-08 |
20120282574 | DEVICE FOR GENERATING GASEOUS SPECIES - The present invention provides a device | 2012-11-08 |
20120282575 | SYSTEM FOR COMPILING KNITTING/CROCHETING PATTERNS INTO STEPWISE TIME-ADJUSTABLE VOICE AND VISUAL INSTRUCTIONS - A system for authoring knitting, crocheting, weaving patterns and other fiber arts patterns, and for converting those patterns into stepwise voice and visual instructions comprising a hardware architecture and modular software including a database of predefined stitch objects each corresponding to a stitching step or sequence. Each stitch object is linked in the database to a sound bite enunciating that stitch step and to a graphic illustration depicting that stitch step with a written explanation. The software includes an authoring module with a pattern compilation user-interface that allows a user to construct a complete pattern by selecting knitting commands from a menu of predefined commands in the database. Once constructed, the pattern is loaded into a playback module which employs an enunciation engine that speaks the complete pattern step-by-step and a playback user interface that displays a visual depiction and description of each step all at a user defined pace. | 2012-11-08 |
20120282576 | System for managing formal mentoring programs - A system and method for facilitating mentoring in an enterprise. An example method includes establishing a set of candidate mentors and a set of candidate mentees; providing a first user option to match a candidate mentor with a candidate mentee from the set of candidate mentors and the set of candidate mentees, respectively, yielding a mentor and an associated mentee in response thereto; selectively tracking a first performance parameter of the mentee over an interval during which a mentoring relationship exists between the mentor and the mentee and providing an indication of a change in the first performance parameter over time; and providing a second user option to initiate an action in response to the indication. The action may include initiating an adjustment in compensation for the mentee or mentor when the indication indicates a particular improvement in one or more performance parameter(s). | 2012-11-08 |
20120282577 | MEASURING COGNITIVE LOAD - A computer implemented method for measuring a person's cognitive load comprises initially receiving | 2012-11-08 |
20120282578 | SYSTEM FOR STRATEGIC MEMORY AND REASONING (SMART) - A cognitive strategy instruction program focusing specifically on the ability to reason, abstract, and generalize information for more efficient learning is described herein. The combination of the strategies in tandem with the intensive presentation and process-related (rather than content-related) approach are unique to the SMART program of the present invention. The SMART approach encompasses various cognitive processes in succession, such as working memory, attention, and synthesis of pre-existing knowledge with new information in contrast to most current cognitive interventions focus on specific aspects of cognition such as working memory in isolation. The SMART program of the present invention can be extended with slight modifications if necessary to adults, particularly in senior citizens to enhance one or more cognitive processes. | 2012-11-08 |
20120282579 | Computer System for Safety Training and Certifying Workers for Work on Structures Having Radio Frequency Antennae - A computerized system for certifying workers to work on a structure having RF antennae, having: (a) an access module to access the computerized system; (b) a non-site-specific training module that displays on-line information about RF antennae; (c) a site-specific training module that displays on-line information about the at least one RF antenna on the structure; (d) a certification module that conducts on-line testing of workers on the non-site-specific information and certifies workers for work at a job site by having the workers acknowledge that they have seen the site-specific information; and (d) a database module which stores: (i) non-site-specific information, (ii) site-specific information, and (iii) records of which workers have both have passed the on-line non-site-specific testing and seen the site-specific information. | 2012-11-08 |
20120282580 | ISO9001 IMPLEMENTATION WORKSHOP - The present disclosure relates to an ISO9001 implementation workshop which combines ISO9001 implementation instruction with a hands-on workshop. The course provides the history and foundation of ISO9001, a complete overview of the ISO9001 standard and review of the key steps to consider for all hospitals with regard to implementing ISO9001 within their organization. The course includes: on-site instruction at a preferred location or site; a two to four day course with full access to a highly trained, knowledgeable ISO accredited consultant; an additional fully trained facilitator to help support the participants during the workshop portion of the course; and, utilizing the healthcare organizations own documentation, coupled with health care's best practices, the actual development of the key documents required for the ISO implementation. | 2012-11-08 |
20120282581 | SYSTEM AND METHOD FOR BEHAVIOR MODIFICATION - A method for producing a behavior modification plan is disclosed which comprises the steps of providing a computer system having a program, the program for allowing input of information, inputting information relating to a behavior modification to be made, inputting information relating to past successes in the behavior modification to be made, inputting information relating to prior and anticipated barriers in the behavior modification to be made, inputting information relating to success in other areas other than the behavior modification to be made, inputting information relating to a preferred learning style, preparing a behavior modification plan based upon the behavior modification to be made, prior barriers, anticipated barriers, and a preferred learning style, and displaying the prepared behavior modification plan. A system for producing a behavior modification plan is also disclosed. | 2012-11-08 |
20120282582 | METHOD OF COLLECTING DATA FROM A SURVEY BY A SYSTEM - An electronic infrastructure consisting a plurality of client mobile devices, a distribution server and network that communicatively couples the plurality of client mobile devices and distribution server, wherein the distribution server collects survey questionnaires from a questionnaire source, distributes survey questionnaire to the plurality of client mobile devices. Then, the distribution server receives responses from the users of plurality of client mobile devices and analyses the responses based upon several criteria. The criteria include region based analysis, race based analysis, age based analysis, other criteria based analysis, high priority analysis and/or satisfaction level analysis. | 2012-11-08 |
20120282583 | SYSTEM AND METHOD FOR PERFORMING A HYBRID SIMULATION OF A MEDICAL PROCEDURE - Embodiments of the invention are directed to a method of performing a simulation of a medical procedure. A physical model of an anatomical structure and of a medical tool may be provided. 3D digital models of the anatomical structure and medical tool may be provided. A location parameter related to a location of the physical medical tool with respect to the physical model of the anatomical structure may be received. The 3D models of the anatomical structure and medical tool may be manipulated according to the location parameter. | 2012-11-08 |
20120282584 | SURGICAL TRAINING AIDS AND METHODS OF FABRICATION THEREOF - The present invention provides surgical training aids formed from hydrogels and adapted to exhibit realistic mechanical properties mimicking those of real organs. Surgical training aids are preferably fabricated by subjecting a concentration of polyvinyl alcohol to freeze-thaw cycles in a mold designed to approximate the shape of an organ, and process parameters are selected to tailor the mechanical properties of the formed hydrogel to those of the organ simulated by the surgical aid. The mechanical properties of the hydrogel forming the surgical training aid may be tailored by incorporating bacterial cellulose and by applying strain during hydrogel formation, thereby producing controlled anisotropy. | 2012-11-08 |
20120282585 | Interest-Attention Feedback System for Separating Cognitive Awareness into Different Left and Right Sensor Displays - A system for generating simultaneous awareness of two separate sensor stimulation patterns ( | 2012-11-08 |
20120282586 | USER CUSTOMIZABLE QUERIES TO POPULATE MODEL DIAGRAMS - A method, computer program product, and system for visually modeling architectures or system designs are described. A method may comprise providing an architectural model having a plurality of elements of one or more types. The method may further comprise providing a platform for a user to develop a non-software code query relating to the elements of the model. The method may also comprise executing the developed query to extract one or more of the plurality of elements from the model. The method may additionally comprise populating a diagram with the extracted one or more of the plurality of elements. | 2012-11-08 |
20120282587 | SYSTEM AND METHOD FOR GENERATING AND IMPLEMENTING INDIVIDUALIZED EDUCATIONAL PRACTICE WORKSHEETS - A method and system generates and administers an individualized student worksheet. A set of problems and a unique embedded data pattern are generated and printed on a worksheet substrate. A teacher may point a camera pen point at an area of the pattern to identify the substrate and a location on the substrate. Based on this information, the method and system may access a worksheet file to identify the problem whose physical position corresponds to the captured embedded data. The system may present the problem's solution to the teacher, who may then use the pen to mark the problem as correct or incorrect, and optionally annotate notes for the student, teacher or others. The camera pen may collect the teacher's marks and annotations and store them with the worksheet file for later retrieval. | 2012-11-08 |
20120282588 | MOBILE PLATFORM - A motion platform for use in a simulator comprising linear slides providing surge and sway, and a rotary table providing yaw. A payload carrying platform is mounted on the rotary table via three bell cranks to provide heave, pitch and roll. | 2012-11-08 |
20120282589 | Air bag simulator / educational device and method - An air bag simulator device essentially functions to educate drivers on proper seat-body position relative to a vehicular air bag deployment zone. The air bag simulator device comprises an air bag-simulating envelope, sized and shaped to simulate a deployed driver side, vehicular air bag. The air bag-simulating envelope defines a certain volumetric space filled with certain matter. The air bag-simulating envelope is positionable adjacent a vehicular steering wheel for visually demonstrating to a user the volumetric space otherwise occupied by a deployed driver side vehicular air bag. The driver, having the air bag simulating device in position, may thus properly position his or her seat and/or body to accommodate the air bag simulating device. Once having learned to anticipate the volumetric space defined by the air bag simulating device, the driver may repeat the process so as to avoid being struck by a vehicular air bag during a deployment. | 2012-11-08 |
20120282590 | Manipulation Device Configured To Be Used With An Interactive Whiteboard And An Interactive Teaching System Including The Same - A manipulation device, which is configured to be used with an interactive whiteboard, includes an elongated rod and a body portion. The elongated rod is connected to the body portion at one of its ends, and the body portion has an outer surface with a layer of foam disposed thereon. The layer of foam disposed on the body portion is configured to be displaced along an outer display surface of an interactive whiteboard so as to facilitate a manipulation of objects displayed on the interactive whiteboard by a user thereof. According to another aspect of the invention, the manipulation device is provided as part of an interactive teaching system, wherein the manipulation device is used in conjunction with an interactive whiteboard having an outer display surface, the interactive whiteboard being operatively coupled to a data processing device. | 2012-11-08 |
20120282591 | Compositions and Methods for Tissue Preservation - Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions. | 2012-11-08 |
20120282592 | BIOMARKER OF DEPRESSION, METHOD FOR MEASURING BIOMARKER OF DEPRESSION, COMPUTER PROGRAM, AND RECORDING MEDIUM - Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the following are used: ADP-ribose, ATP, ADP, AMP, serotonin, tryptophan, kynurenine, SDMA (symmetrical dimethylarginine), threonine, glyceric acid, serine, N-acetylaspartic acid, glutamic acid, trigonelline, creatine, 2-methylserine, sphingosine, homovanillic acid, piperidine, sulfoxidized methionine, pipecolic acid, sphinganine, gamma-butyrobetaine, guanidinoacetic acid, isobutyric acid, creatinine, sarcosine, 3-methylbutyric acid, nicotinamide, betaine, ornithine, carnitine, ethanolamine, phosphoethanolamine, taurine, hypotaurine, aspartic acid, methionine, and tyrosine. | 2012-11-08 |
20120282593 | Method and Kit for Detecting Virulent Strains of Influenza Virus - The present invention is a kit and method for determining the virulence of an influenza virus based upon the presence or absence of leucine at position 62, arginine at position 75, arginine at position 79 and leucine at position 82 of the polymerase basic 1-F2 protein amino acid sequence. | 2012-11-08 |
20120282594 | METHOD OF ENHANCED DETECTION FOR NANOMATERIAL-BASED MOLECULAR SENSORS - Sensors based on single-walled carbon nanotubes and graphene which demonstrate extreme sensitivity as reflected in their electrical conductivity to gaseous molecules, such as NO, NO | 2012-11-08 |
20120282595 | HIGH THROUGHPUT CELL-BASED HPV IMMUNOASSAYS FOR DIAGNOSIS AND SCREENING OF HPV-ASSOCIATED CANCERS - Methods for quantifying an HPV protein expression in a clinical sample are disclosed. The quantifying methods include the process for obtaining the clinical sample. Such a clinical sample is consisted of a population of cells that are susceptible to infection by an HPV. The quantifying methods also include the process for depositing the clinical sample into a container. The clinical sample is contacted with the first antibody that specifically binds to an HPV protein which is expressed by an HPV-infected cell under a condition that promotes specific binding of the first antibody to the HPV protein expressed by the population of cells. The methods further include the process for quantifying the specific binding of the first antibody and thereby quantifying the HPV protein expression in the clinical sample. The assay provides an objective test to identify patients with high-grade precursor from cytology samples before biopsy. | 2012-11-08 |
20120282596 | Sensor for Biomolecules - A method for sensing biomolecules in an electrolyte includes exposing a gate dielectric surface of a sensor comprising a silicon fin to the electrolyte, wherein the gate dielectric surface comprises a dielectric material and antibodies configured to bind with the biomolecules; applying a gate voltage to an electrode immersed in the electrolyte; and measuring a change in a drain current flowing in the silicon fin; and determining an amount of the biomolecules that are present in the electrolyte based on the change in the drain current. | 2012-11-08 |
20120282597 | BIOMARKER AND METHOD FOR EVALUATING RISK OF PROLIFERATION, INVASION, OR METASTASIS OF CANCER - The present invention relates to a biomarker associated with a cancer and a method using the biomarker to evaluate a risk of proliferation, invasion, or metastasis of a cancer. The method of the present invention comprises the following steps: (A) providing a tissue sample to evaluate for risk of proliferation, invasion, or metastasis of a cancer, wherein the tissue sample comprises a non-cancer region, and a suspected cancer region; (B) detecting expression levels of a biomarker and a predetermined standard in the non-cancer region and the suspected cancer region respectively, wherein the biomarker is T-cell lymphoma invasion and metastasis 2 (TIAM2); (C) comparing the expression levels of the biomarker and the predetermined standard in the non-cancer region to the expression levels of the biomarker and the predetermined standard in the suspected cancer region. | 2012-11-08 |
20120282598 | White Blood Cell Analysis System and Method - Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (WBC) differential analysis. The systems and methods screen WBCs by means of fluorescence staining and a fluorescence triggering strategy. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder WBC reagent(s), suitable for assays of samples containing fragile WBCs. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye, which corresponds in emission spectrum to an excitation source of a hematology instrument; (b) using a fluorescence trigger to screen the blood sample for WB Cs; and (c) using measurements of (1) axial light loss, (2) intermediate angle scatter, (3) 90° polarized side scatter, (4) 90° depolarized side scatter, and (5) fluorescence emission to perform a differentiation analysis. | 2012-11-08 |
20120282599 | Nucleated Red Blood Cell Analysis System and Method - Systems and methods for analyzing blood samples, and more specifically for performing a nucleated red blood cell (nRBC) analysis. The systems and methods screen a blood sample by means of fluorescence staining and a fluorescence triggering strategy, to identify nuclei-containing particles within the blood sample. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder reagent(s), suitable for assays of samples containing fragile white blood cells (WBCs). In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; (b) using a fluorescence trigger to screen the blood sample for nuclei-containing particles; and (c) using measurements of light scatter and fluorescence emission to distinguish nRBCs from WBCs. | 2012-11-08 |
20120282600 | Basophil Analysis System and Method - Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other WBC sub-populations. In one embodiment, the systems and methods include performing a basophil cluster analysis of the blood sample, based on the combination of light scatter and fluorescence measurements. | 2012-11-08 |
20120282601 | BLOOD ANALYZER, BLOOD ANALYSIS METHOD, AND COMPUTER PROGRAM PRODUCT - A blood analyzer, a blood analysis method, and a computer program product that can distinguishably detect abnormal lymphocytes, blasts, and atypical lymphocytes are provided. A blood analyzer prepares a first measurement sample from a first reagent containing a hemolyzing agent, a second reagent containing a fluorescence staining dye, and the blood specimen, and prepares a second measurement sample from a third reagent containing a hemolyzing agent, a fourth reagent containing a fluorescence staining dye, and the blood specimen. The blood analyzer measures each of the measurement samples, and distinguishably detects abnormal lymphocytes, blasts, and atypical lymphocytes in a blood specimen based on the measurement data. | 2012-11-08 |
20120282602 | MULTIPLE- ANALYTE ASSAY DEVICE AND SYSTEM - Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications. | 2012-11-08 |
20120282603 | AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE - A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases. | 2012-11-08 |
20120282604 | Copy Number Variation Determination, Methods and Systems - The present invention methods and systems for determining copy number variation of a target polynucleotide in a genome of a subject including amplification based techniques. Methods can include pre-amplification of the sample followed by distribution of sample and a plurality of reaction volumes, quantitative detection of a target polynucleotide and a reference polynucleotide, and analysis so as to determine the relative copy number of the target polynucleotide sequence in the genome of the subject. | 2012-11-08 |
20120282605 | PROCESS CONTROLS FOR MOLECULAR ASSAY - A full process control for use with a molecular assay and a method of determine the efficacy of the molecular assay. A full process control can include a fixed cell, and specifically can include a fixed vegetative cell. A method of determining the efficacy of a molecular assay can include providing an internal control, mixing the internal control with a sample, lysing the internal control and the sample, and detecting the lysis product. The full process control and/or the internal control can be | 2012-11-08 |
20120282606 | METHOD, KITS AND REACTION MIXTURES FOR HIGH RESOLUTION MELT GENOTYPING - Various methods are described that provide for high resolution melt (HRM) genotyping. Some embodiments comprise providing a locus specific primer, and two allele specific primers each comprising at least one single nucleotide polymorphism (SNP) allele-hybridizable sequence, wherein at least one of the allele specific primers also comprises at least one nucleotide alteration. In some embodiments, a nucleic acid is provided comprising a SNP base located within 1-20 bases of its 3′ end. Some embodiments comprise hybridizing the locus specific primer and at least one of the allele specific primers to the nucleic acid, amplifying the hybridized nucleic acid using pyrophosphorolysis activated polymerization (PAP) PCR, and determining the melting temperature (Tm) of the resulting amplicons, for example, using HRM. In some embodiments, reaction mixtures and kits for HRM genotyping are provided. | 2012-11-08 |
20120282607 | Probe, Polymorphism Detection Method, Method of Evaluating Drug Efficacy or Tolerance, Disease Prediction Method and Reagent Kit - A probe for detecting polymorphism in the ABCG2 gene is constituted by including, for example, an oligonucleotide which is complementary to a base sequence including the 301st to the 311th bases of the base sequence indicated in SEQ ID NO:1 and having a length of from 11 bases to 50 bases, and has an identity of at least 80%, and in which a base corresponding to the 311th base has been labeled with a fluorescent dye. | 2012-11-08 |
20120282608 | Probe, Polymorphism Detection Method, Method of Evaluating Drug Efficacy or Tolerance, and Reagent Kit - A probe for detecting polymorphism in the ABCC2 gene is constituted by including, for example, an oligonucleotide which is complementary to a base sequence including the 207th to the 217th bases of the base sequence indicated in SEQ ID NO:1 and having a length of from 11 bases to 60 bases, and has an identity of at least 80%, and in which a base corresponding to the 217th base has been labeled with a fluorescent dye. | 2012-11-08 |
20120282609 | Gene Mutation Detection Probe - A gene mutation detection probe for detection of a target gene mutation in a base sequence encoding a gene of interest that includes the target gene mutation and a non-target gene mutation, the probe including at least one oligonucleotide selected from the group consisting of oligonucleotides P1, P1-1, P1′, and P 1′-1. For example, the P1 oligonucleotide is an oligonucleotide that has, at a base position corresponding to the target gene mutation, a base complementary to either a wild-type base or a mutant base of the target gene mutation, and has, at a base position corresponding to the non-target gene mutation, a base complementary to neither a wild-type base nor a mutant base of the non-target gene mutation, and has an identity of at least 80% with a base sequence complementary to a part or an entirety of the base sequence encoding the gene of interest | 2012-11-08 |
20120282610 | Oligonucleotides for Detection Test of Polymorphism of EGFR Exon 19 and Use Thereof - An oligonucleotide for a detection test of a polymorphism of EGFR exon 19, the oligonucleotide being at least one selected from the group consisting of a P1 oligonucleotide and a P1′ oligonucleotide, the P1 oligonucleotide having a 3′ end subjected to an extension inhibition treatment, which has an identity of at least 80% with respect to a base sequence including at least the 115th to the 123rd bases of the base sequence indicated in SEQ ID NO: 1 and has a length of from 9 to 80 bases; and the P1′ oligonucleotide having a 3′ end subjected to an extension inhibition treatment, which hybridizes under stringent conditions with a complementary strand of a base sequence including at least the 115th to the 123rd bases of the base sequence indicated in SEQ ID NO: 1 and having a length of from 9 to 80 bases. | 2012-11-08 |
20120282611 | METHODS, KITS AND REACTION MIXTURES FOR ANALYZING SINGLE-STRANDED NUCLEIC ACID SEQUENCES - Provided herein are fluorescence detection methods for nucleic acid sequences and to kits for performing such methods. | 2012-11-08 |
20120282612 | METHOD FOR ANALYZING PSA, AND A METHOD FOR DISTINGUISHING PROSTATE CANCER FROM PROSTATIC HYPERTROPHY USING THAT METHOD FOR ANALYZING PSA - A method for distinguishing prostate cancer from prostatic hypertrophy using the method for analyzing PSA and an analysis kit of PSA are provided. | 2012-11-08 |
20120282613 | METHODS AND COMPOSITIONS FOR NONINVASIVE PRENATAL DIAGNOSIS OF FETAL ANEUPLOIDIES - The invention provides methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies. A large panel of differentially methylated regions (DMRs) have been identified. Certain of these DMRs are hypomethylated in adult female blood DNA and hypermethylated in fetal DNA, whereas others are hypermethylated in adult female blood DNA and hypomethylated in fetal DNA. Moreover, DMRs that are hypomethylated in adult female blood DNA and hypermethylated in fetal DNA have been shown to accurately predict a fetal aneuploidy in fetal DNA present in a maternal blood sample during pregnancy. In the methods of the invention, hypermethylated DNA is physically separated from hypomethylated DNA, preferably by methylated DNA immunoprecipitation. | 2012-11-08 |
20120282614 | METHODS AND NUCLEIC ACIDS FOR THE DETECTION OF METASTASIS OF COLON CELL PROLIFERATIVE DISORDERS - The invention provides methods, nucleic acids and kits for detecting metastasis of colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of metastasis of colon cell proliferative disorders, thereby enabling the improved diagnosis and treatment of patients. | 2012-11-08 |
20120282615 | METHODS OF SCREENING FOR COMPOUNDS FOR USE AS MODULATORS OF LEFT-RIGHT ASYMMETRY IN SCOLIOTIC SUBJECTS AND FOR MONITORING EFFICACY OF AN ORTHOPAEDIC DEVICE - A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and/or left side of the spine of a subject; and (b) determining at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and/or activity in the cell sample; wherein the test compound is selected as potentially useful in treating or preventing AIS if at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and/or activity in the cell sample is different in the presence of the test compound as compared to in the absence thereof. | 2012-11-08 |
20120282616 | TREATMENT OF A SAMPLE WITH FOCUSED ACOUSTIC ENERGY - A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device. | 2012-11-08 |
20120282617 | DETECTION USING A DYE AND A DYE MODIFIER - The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such as nucleic acids, cells and microorganisms. The present invention also provides various methods of using the dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions. | 2012-11-08 |
20120282618 | METHODS AND ASSAYS FOR RISK PREDICTION, DIAGNOSIS, AND ANALYSIS OF MYOCARDIAL INFARCTION, HEART FAILURE AND REDUCED CARDIAC FUNCTION - Methods and kits adapted for risk prediction, diagnosis, and analysis of myocardial infarction (MI), myocardial failure, and reduced cardiac function such as heart failure. The methods include collecting a sample of human body fluid or tissue from a subject and then identifying the presence of cardiac myosin binding protein-C 25-nucleotide deletion and/or detecting the presence of cardiac myosin binding protein-C, its peptides, its phosphorylation status, and/or its autoantibodies in the human body fluid or tissue. | 2012-11-08 |
20120282619 | METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS - The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient. | 2012-11-08 |
20120282620 | Method of Manufacturing Reference Material Using Plant Cultured Cell Lines - A method of manufacturing a reference material for determining incorporation of a genetically modified (GM) plant into a sample or analyzing a mixing ratio from a tissue-cultured cell line that is obtained by incubating tissues of either a GM plant or a non-GM plant, and a method of determining incorporation of a GM plant into a sample and analyzing a mixing ratio using the reference material are provided. The reference material for determining the incorporation of a genetically modified (GM) plant a sample or analyzing a mixing ratio using the tissue-cultured cell lines that are obtained by incubating tissues of the GM plant and the non-GM plant can be useful in producing a countless number of populations having the same genetic traits via the tissue culture. Thus, when a culture capacity of the reference material is increased to a large volume, it is possible to obtain a large volume of the reference material having uniform qualities with no quality variation between batches. Unlike the conventional reference materials manufactured using grain powder, a reference material with 100% purity can be obtained as either a GM or non-GM reference material by verifying the purity of the tissue-cultured cell line. Accordingly, it is possible to provide the uniform and stable supply of a reference material having uniform compositions. | 2012-11-08 |
20120282621 | METHODS AND COMPOSITIONS FOR ASSESSMENT OF PULMONARY FUNCTION AND DISORDERS - The present invention provides methods for the assessment of risk of developing chronic obstructive pulmonary disease (COPD), emphysema or both COPD and emphysema in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing COPD, emphysema or both COPD and emphysema. | 2012-11-08 |
20120282622 | MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571 - The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS. | 2012-11-08 |
20120282623 | RAPID PATHOGEN DETECTION TECHNIQUES AND APPARATUS - Methods for selectively detecting a live pathogen in a sample containing live and dead pathogens, without detecting the dead pathogen are disclosed. Such methods may include: (i) immobilizing at least a portion of the live and dead pathogens on a solid support with a physical barrier; (ii) incubating the solid support in a growth medium, where the live pathogen can multiply and the multiplied pathogen move from the solid support to a supernatant of the growth medium; and (iii) detecting the multiplied pathogen in the supernatant by a pathogen assay. | 2012-11-08 |
20120282624 | INTEGRATION OF GENES INTO THE CHROMOSOME OF SACCHAROPOLYSPORA SPINOSA - This invention includes a process for the identification and validation of a neutral polynucleotide integration site within the | 2012-11-08 |
20120282625 | MICROFLUIDIC DEVICE COMPRISING MICROCHANNEL WHERE PROTRUSIONS ARE FORMED ON BOTTOM SURFACE - Disclosed is a microfluidic device comprising a microchannel through which fluid can flow. Protrusions are formed on the bottom surface of the microchannel. The microfluidic device increases detection sensitivity by improving optical characteristics and enhances the reactivity of biochemical reaction by slowing down the velocity of fluid flowing inside the microchannel. | 2012-11-08 |
20120282626 | Selective Incorporation of 5-hydroxytryptophan into Proteins in Mammalian Cells - This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation. | 2012-11-08 |
20120282627 | CRYSTAL OF HYPOXIA INDUCIBLE FACTOR 1 ALPHA PROLYL HYDROXYLASE - The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders. | 2012-11-08 |
20120282628 | METHOD FOR DIAGNOSING CANCER USING LECTIN - The present invention relates to a method for diagnosing cancer using information on aberrant glycosylation of glycoproteins, which is related with cancer progression. More particularly, the present invention relates to a peptide marker for cancer diagnosis and a method for diagnosing cancer using the peptide marker, wherein glycoproteins aberrantly glycosylated due to cancer incidence and progression is isolated using lectin; and marker peptides generated by hydrolysis of the glycoproteins isolated by the lectin is selected and quantified. | 2012-11-08 |
20120282629 | Enhancers of Protein Degradation - The present invention relates to compounds suitable for modulating huntingtin protein processing and useful for treating or preventing huntingtin-related disorders. The invention provides pharmaceutical compositions comprising said compounds and methods of syntheses thereof. | 2012-11-08 |
20120282630 | MIXED-METAL SUBSTRATES FOR METAL-ENHANCED FLUORESCENCE - The present invention provides for mixed metal structures that can be deposited on a substrate or free in solution that exhibit several distinctive properties including a broad wavelength range for enhancing fluorescence signatures. Further, metal surface plasmons can couple and such diphase coupled luminescence signatures create extra plasmon absorption bands. The extra bands allow for a broad range of fluorophores to couple therefore making more generic substrates with wider reaching applications. | 2012-11-08 |
20120282631 | METHOD FOR DIAGNOSIS NON-SMALL-CELL-LUNG-CARCINOMA (NSCLC) AND CLASSIFICATION OF ITS SUBTYPES WITH DIFFERENT COMBINATIONS OF 6 PROTEIN BIOMARKERS - A method of identifying and classifying non-small-cell lung carcinoma in a biological sample includes a first test wherein the expression level of at least one biomarker is measured in a sample, the at least one=biomarker is selected from a first group consisting of chaperonin, 2,3-bisphosphoglycerate mutase, thymidine phosphorylase, and minichromosome maintenance deficient protein 5, and comparing the measured expression levels against a normal expression level, wherein a significant difference diagnoses or aids in the diagnosis of non-small cell lung carcinoma; and a second test wherein the expression level of at least one biomarker is measured in the sample, the at least one biomarker is selected from a second group consisting of selenium binding protein and Napsin A, and comparing the measured expression level against a normal expression level, wherein a significant difference confirms or aids in confirmation of Non-Small Cell Carcinoma. | 2012-11-08 |
20120282632 | FUNCTIONALIZED CHROMOPHORIC POLYMER DOTS AND BIOCONJUGATES THEREOF - The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed. | 2012-11-08 |
20120282633 | ANTIBODY SPECIFIC TO ACTIVATED EGFR - Disclosed is a means for accurately measuring activated EGFR regardless of whether phosphorylation has occurred or not. The antibody or antigen-binding fragment thereof according to the present invention can bind to activated EGFR regardless of whether the activated EGFR is in a phosphorylated form or in a nonphosphorylated form. By carrying out an immunoassay using the antibody or antigen-binding fragment thereof, activated EGFR in a sample can be measured more accurately than by conventional methods. Abnormal activation of EGFR is responsible for the onset of cancer, and is regarded as a therapeutic target. Therefore, the antibody or antigen-binding fragment thereof according to the present invention is also useful for detection of cancers, in particular, cancers to which a molecular target drug(s) whose target is EGFR is(are) to be administered. | 2012-11-08 |
20120282634 | BLOOD SEPARATION SYSTEM AND METHOD FOR A DRY TEST STRIP - A dry test strip layer for filtering red blood cells includes a Borosilicate Glass Fiber layer and lectin, impregnated in the borosilicate layer, such that the dry test strip is configured to filter red blood cells from a blood sample. | 2012-11-08 |
20120282635 | SELF-CALIBRATING GRADIENT DILUTION IN A CONSTITUTENT ASSAY AND GRADIENT DILUTION APPARATUS PERFORMED IN A THIN FILM SAMPLE - A method and apparatus for measuring antibody titers in a thin film sample in an automated system which does not require multiple dilutions. The system provides a simple method for creating an in-situ dilution within a sample analysis chamber without the use of any precision fluid-handling components, and further, to use the same principles to provide a wide range of sample dilutions within the chamber so as to obviate the need for additional dilution steps when dealing with samples possibly containing wide ranges of analyte concentrations. | 2012-11-08 |
20120282636 | Diagnostic Device - The invention provides for rapid response analysis through lateral flow chromatographic assays of specific antigens present in human or animal fluids, or in agricultural, microbial or biological products, with an audio and visual result of the analysis and when needed, an electronic surge to provide heat for rapid results. A lateral flow device for conducting the analysis includes a plurality of components, and a method for making the device forms components of the device on an elongate, ribbon-like substrate of dielectric material, then folds the substrate into shorter lengths which are then secured together to establish a multiple-layered, self-sustaining structure. | 2012-11-08 |
20120282637 | POLYPEPTIDES FOR BINDING TO THE RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS AS WELL AS COMPOSITIONS AND METHODS INVOLVING - The present invention relates to a polypeptide or polypeptide complex comprising at least the two amino acid sequences arranged to allow for specific binding to the “receptor for advanced glycation endproducts” (RAGE), one or more nucleic acid(s) coding for the polypeptide or polypeptide complex, a cell producing an antibody against RAGE, a pharmaceutical composition comprising at least one polypeptide or nucleic as defined above, optionally for treating a RAGE-related disease or disorder and a method of diagnosing a RAGE-related disease or disorder. | 2012-11-08 |
20120282638 | METHOD FOR IMMUNOASSAY OF AUTOANTIBODY AGAINST KU86, KIT FOR USE IN SAME, AND METHOD FOR DETERMINATION OF PRIMARY HEPATOCELLULAR CARCINOMA USING SAME - An autoantibody against Ku86 can be measured by reacting the autoantibody contained in a sample with a Ku86 antigen (which serves as a reagent) to produce an immune complex of the autoantibody and the Ku86 antigen and measuring the immune complex using a labeled anti-human immunoglobulin antibody. The measurement of the autoantibody enables the determination of primary hepatocellular carcinoma. | 2012-11-08 |
20120282639 | LIGHT COLLECTION SYSTEM - The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source. | 2012-11-08 |
20120282640 | METHODS OF MEASURING CELL VIABILITY IN TISSUE ENGINEERED PRODUCTS - This invention provides methods of measuring the viability of cultured cells by detecting one or more cell death-stable proteins or enzyme activities. Methods provided by the invention correlate viability to relative levels of enzyme activity in cell-containing and non-cell-containing fractions of a cell culture. | 2012-11-08 |
20120282641 | METHOD OF IDENTIFYING PEPTIDES - Methods of identifying polypeptides have been developed using a de novo sequencing technique. Methods use photodissociation and low-energy fragmentation and the spectra of peptide ions obtained therefrom, such as obtained by post-source decay (PSD), have been developed. The methods include photodissociation and the spectra therefrom obtainable from treating ions with predetermined wavelengths of radiation in the vacuum ultraviolet range of the electromagnetic spectrum. The confidence of amino acid assignments based on x-type ions is evaluated by observing complementary y-, v- and w-type ions that provide additional constraints to sequence identification. | 2012-11-08 |
20120282642 | METHODS FOR MEASURING THE METABOLISM OF NEURALLY DERIVED BIOMOLECULES IN VIVO - The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for neurological and neurodegenerative diseases and disorders, such as Alzheimer's Disease, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of biomolecules produced in the CNS in a subject are provided. | 2012-11-08 |
20120282643 | CYAN AND YELLOW FLUORESCENT COLOR VARIANTS OF SPLIT GFP - Disclosed herein are Split-Fluorescent proteins (SFPs) including Split-Yellow Fluorescent Proteins and Split-Cyan Fluorescent proteins. Further disclosed are methods of using SFPs. For example, methods of identifying the subcellular localization of a protein and methods of identifying the membrane topology of a membrane protein are disclosed herein. | 2012-11-08 |
20120282644 | MULTIPLE-ELECTRODE AND METAL-COATED PROBES - Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided. | 2012-11-08 |
20120282645 | NANOPARTICLES - Nanoparticles, compositions comprising the nanoparticles, and methods for manufacture and uses thereof are provided. In at least one specific embodiment, the nanoparticle can include at least one isotopically enriched metal oxide. The isotopically enriched metal oxide can be copper or zinc. | 2012-11-08 |
20120282646 | METHOD FOR ACTIVATING A NATURAL KILLER CELL BY ADJUSTING THE EXPRESSION OF THE SOCS2 GENE - The present invention relates to a method for activating natural killer cells (NK cells), and more particularly, to a method for enhancing the cytotoxicity of natural killer cells by inducing the overexpression of suppressor of cytokine signaling 2 (SOCS2) which is a protein involved in cell-signaling pathways in natural killer cells. The inventors of the present invention observed that when natural killer cells were treated with IL-15, a cytokine involved in natural killer cell differentiation, the expression of SOCS2 increased and the expression of proline-rich tyrosine kinase 2 (Pyk2) was inhibited by the SOCS2, the expression of which increased. In addition, when Pyk2 was overexpressed, the ability to produce IFN-γ and the ability to kill tumor cells of natural killer cells decreased. Therefore, SOCS2 can be used for activating natural killer cells and the natural killer cells activated by the method can be used for the prevention or treatment of cancer. | 2012-11-08 |
20120282647 | ASSAY FOR QUANTIFYING CLOSTRIDIAL NEUROTOXIN - Method of measuring an effect induced to a muscle tissue by a clostridial neurotoxin, comprising:
| 2012-11-08 |
20120282648 | METHOD AND SYSTEM FOR DETECTING AND GRADING PROSTATE CANCER - A method of analyzing a plurality of biopsy cores extracted from a plurality of respective biopsy locations in a prostate is disclosed. The method comprises: measuring a level of a chemical element in each of the biopsy cores, and generating a chemical element map of at least a portion of the prostate based on the levels and the respective biopsy locations. In some embodiments, the method determines at least one additional biopsy location for a future biopsy in the prostate. | 2012-11-08 |
20120282649 | FLUORESCENCE DETECTING APPARATUS, FLUORESCENCE DETECTING METHOD, AND FLUORESCENCE SIGNAL PROCESSING METHOD - Disclosed herein is a fluorescence detecting apparatus. The fluorescence detecting apparatus includes a light-receiving element that receives fluorescence emitted from an object to be measured irradiated with laser light modulated at a predetermined frequency and outputs a fluorescence signal at an adjusted output level; a signal processing unit that mixes the outputted fluorescence signal and a modulation signal with the frequency to generate fluorescence data including information about phase and intensity; and an analyzing device that calculates a first phase shift of the fluorescence emitted from the object to be measured with respect to the modulation signal, calculates a second phase shift by correcting the calculated first phase shift depending on conditions for adjusting the output level, and calculates a fluorescence relaxation time of the fluorescence emitted from the object to be measured using the calculated second phase shift. | 2012-11-08 |
20120282650 | COMPOSITE MATERIAL - A composite material includes a body and a plurality of nano-scale probes. The body is made of a polymer. The plurality of nano-scale probes is embedded in the body. The nano-scale probes are substantially uniformly distributed in the polymer matrix. The nano-scale probes are nanowires, nano-particles or nanotubes | 2012-11-08 |
20120282651 | System and Method of Co-Cultivating Microalgae with Fungus - One of the most important technical barriers for algal biofuel is the substantial harvesting and extracting cost. The present invention includes a system and method for the pelletization of single cell microalgae through co-cultivation with filamentous fungi to enable the low cost separation of microalgae from liquid medium and to significantly increase the biomass and lipid yield. | 2012-11-08 |
20120282652 | PREPARATION OF PEPTIDE MIXTURES BY PROTEASE CATALYSIS DESIGNED TO PROVIDE USEFUL BIOLOGICAL AND PHYSICAL PROPERTIES - A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide. | 2012-11-08 |
20120282653 | METHOD FOR MAKING POLYPEPTIDES - The invention provides an improved method for producing polypeptides with a C-terminal glycine in a yeast transformant being characterized in having a non functional KEX1 gene. The method is in particular well suited to produce polypeptides with an aromatic amino acid residue attached to the C-terminal glycine. The yeast strain may have further non-functional protease genes selected from PEP4, YPS1, MKCI, YPS3, YPS5, YPS6, YPS7, PRB1, STE13 and KEX2. | 2012-11-08 |
20120282654 | ANTIBODY PURIFICATION - The present invention provides, in part, a multi-step process for purifying antibodies including chromatographic purification and filter purification. | 2012-11-08 |
20120282655 | ENHANCED SOLUBLE C5 SACCHARIDE YIELDS - Methods are disclosed for increasing the level of soluble C | 2012-11-08 |
20120282656 | MULTISTAGE FRACTIONATION PROCESS FOR RECALCITRANT C5 OLIGOSACCHARIDES - Methods are disclosed for increasing the level of C | 2012-11-08 |
20120282657 | ENHANCING SPINOSYN PRODUCTION WITH OXYGEN BINDING PROTEINS - The invention describes the integration of polynucleotides into chromosomal DNA of | 2012-11-08 |
20120282658 | Alpha-Amylase Variants and Polynucleotides Encoding Same - The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes. | 2012-11-08 |
20120282659 | NOVEL BETA-GALACTOSIDE-ALPHA2,6-SIALYLTRANSFERASE, A GENE ENCODING THEREOF, AND A METHOD FOR ENHANCING ENZYME ACTIVITY - The present invention provides an extremely useful and novel β-galactoside-α2,6-sialyltransferase having an optimum reaction pH in a neutral to alkaline range, and a nucleic acid encoding the sialyltransferase. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with the vector, as well as a method for producing a recombinant β-galactoside-α2,6-sialyltransferase. | 2012-11-08 |
20120282660 | NOVEL METHOD FOR PROCESSING LIGNOCELLULOSE CONTAINING MATERIAL - The invention is related to a method for processing biomass derived from plants or animals, comprising the steps of: | 2012-11-08 |
20120282661 | MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID - The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. | 2012-11-08 |
20120282662 | METHODS OF AND SYSTEMS FOR PRODUCING DIESEL BLEND STOCKS - A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, extracting neutral lipids from the algal biomass, and esterifying the neutral lipids with a catalyst in the presence of an alcohol. The method also includes separating a water soluble fraction comprising glycerin from a water insoluble fraction comprising fuel esters and distilling the fuel esters under vacuum to obtain a C16 or shorter fuel esters fraction, a C16 or longer fuel ester fraction, and a residue comprising carotenoids and omega-3 fatty acids. The method further includes hydrogenating and deoxygenating at least one of (i) the C16 or shorter fuel esters to obtain a jet fuel blend stock and (ii) the C16 or longer fuel esters to obtain a diesel blend stock. | 2012-11-08 |
20120282663 | METHODS AND COMPOSITIONS FOR PRODUCING FATTY ALCOHOLS AND FATTY ALDEHYDES - Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels. | 2012-11-08 |
20120282664 | PROCESS FOR PRODUCTION OF ETHANOL FROM BIOMASS - An object of the present invention is to provide a method for producing ethanol efficiently even in the presence of a fermentation inhibitor in a saccharified biomass. The present invention provides a method for producing ethanol from biomass, comprising: culturing a transformed xylose-utilizing yeast to overexpress the gene for at least one pentose phosphate pathway metabolic enzyme, with a saccharified biomass. | 2012-11-08 |
20120282665 | Method and Apparatus for Bio-Fuel Seeding - A method and apparatus is provided for microbial seeding and amendment of traditional alternative fuels production systems and processes using immobilized microbe bioreactors. The system addition utilizes attachment of yeast or other microbial consortia to a substrate to enhance alternative fuels production in fermentation processes. The system allows for the maintenance of a constant concentrated microbial population, thus enhancing alternative fuels production by stabilizing microbial populations. Desired aerobic and anaerobic conditions are maintained using a microbubble aeration device coupled to the Immobilized Microbe Bioreactor (IMBR) seeding reactors. Generation of the microbial populations for seeding requires control of aerobic and anaerobic conditions to ensure growth of a microbial population acclimated to elevated alternative fuels concentrations. | 2012-11-08 |
20120282666 | METHOD FOR PRODUCING ETHANOL - The present invention provides a method for producing ethanol, including: subjecting a cellulose-based material to a hot-water treatment and an ammonia treatment to obtain a fermentation substrate; and reacting the fermentation substrate with a yeast to produce ethanol. The present invention also provides a method for producing a fermentation substrate for ethanol production by a yeast, including: subjecting a cellulose material to a hot-water treatment and an ammonia treatment to obtain a fermentation substrate. Thus obtained fermentation substrate can enhance the ethanol production by yeast. | 2012-11-08 |
20120282667 | METHOD FOR POSITIONING BIOLOGICAL SAMPLES IN A MICROSCOPIC ARRANGEMENT - The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices arc proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and, in doing so, the specimen is held so that a substantially unobstructed view of the specimen is ensured from every detection direction. In different constructional variants, the specimen is held at a supporting device by adhesive forces or by a flowing medium, the specimen is held at a capillary opening by capillary action, or at least one specimen is embedded in a body of transparent gel, and the gel body is fixed in the specimen space by means of a rotatable holding device, and the detection direction is changed by rotating the holding device by a given angle of rotation. | 2012-11-08 |