45th week of 2009 patent applcation highlights part 32 |
Patent application number | Title | Published |
20090275007 | System and Method for Strength Training - A method of strength training that includes initiating eccentric contraction of a muscle of interest at a starting position where the muscle of interest is maximally flexed without losing contraction force or increasing the load on a joint. The method also includes eccentrically contracting the muscle of interest through a Contractile Reversal Phase up to a J-Point. When the J-Point is observed the method includes initiating concentric contraction of the muscle of interest to return the muscle of interest to the starting position. | 2009-11-05 |
20090275008 | Coaching Stick Agility Training Device, Swivel Clip and Assembly - A training aid for use during footwork, coordination, speed and/or agility training exercises is provided. The training aid is one or more obstacles about which a player weaves, jumps, or ducks and includes at least one coaching stick. The coaching stick is elongate, has opposite free ends, and has a transverse cross-section that is uniform along substantially a full length of the coaching stick. Preferably, the coaching stick is elliptical in transverse cross-section and defines an elliptical outer periphery that has a width greater then its depth. Accordingly, the coaching stick has a wide face as viewed in one direction and a narrow face as viewed in a different direction. Swivel clips for connecting coaching sticks together and methods of assembling a training circuit are also disclosed. | 2009-11-05 |
20090275009 | SYSTEM AND METHOD FOR SCHOOL PROGRESS REPORTING - A method of determining staff effect and/or school effect on the educational progress of a student attending the school comprising the steps of selecting, collecting and verifying organizational, staff, and student information; transforming the collected information into data having relationships with other collected information usable by a system; analyzing the related data to produce a computer generated value-added metric that represents the academic growth of a student; and generating a report. | 2009-11-05 |
20090275010 | TELEVISION VIERWERS INTERACTION VOTING - A multi-talented show idea and voting methods to find a winner in multi-categories of tasks and talents through voting is disclosed. Viewers who vote for their favorite contestant and show via phone or internet has a chance to win a prize. Viewer vote via phone by using at least one of different calling number and same calling number. The future contestants who records a demo after calling to the show is contacted via phone, mail, web or television. A plurality of contestants participating in the show is separated into a plurality of groups that competes to win a spot as finalists. Said finalists and a second chance contestant chosen by the viewers compete in the elimination show called “R-u-Multi-Talented” to become at least one of three contestants for the “Final three showdown”. At least one among said three contestants is announced as winner and is given the title “U-r-Multi-Talented”. | 2009-11-05 |
20090275011 | SESSILE STEM CELLS - Sterile, virally safe, heterologous, homologous, isologous or autologous tissue, tissue-typed or not tissue-typed, which contains predifferentiated and/or differentiable sessile stem cells and which can be used for wound closure and/or promotion of wound healing. | 2009-11-05 |
20090275012 | Process For Determining S-Nitrosothiols In Biological Fluids - A process for determining S-nitrosothiols, in particular S-nitrosoglutathione, in biological fluids that is easy, selective, cheap with respect to the prior art, which requires the use of equipment commonly available in laboratories, at low cost, which can be used by not qualified operators. The process is based on the hydrolysis of S-nitrosoglutathione (GSNO) by an enzyme, in particular γ-glutamyltranspeptidase (GGT). This enzyme hydrolizes the residual 7-glutamyl of GSNO for giving glutamate (GIu) and S-nitroso-cysteinylglycine (GIyCySNO). In the presence of ions of transition metals GGT speeds up the release of NO since the intermediate that is formed, the GIyCySNO, is is much more sensitive to a metal-dependent decomposition. Advantageously, the amount of nitric oxide present in the sample is measured through a reaction thereof with 4,5 diaminof luorescein (DAF-2), said reaction creating a fluorescent compound in an amount proportional to the S-nitrosothiol amount present in the sample. Alternatively, the amount of released NO can be measured by a chemiluminescence analyser, commercially available. In the presence of biological fluids having complex matrix, the introduction of the enzyme is done after separation of the S-nitrosothiol from the other components of the fluid. | 2009-11-05 |
20090275013 | Method for preparing a monoclonal antibody to the common epitope of nonstructural NSs protein of watermelon silver mottle virus and assay for detection of serological related species in the genus tospovirus with the monoclonal antibody - The invention is an assay for detection of Watermelon silver mottle virus (WSMoV)-serogroup tospoviruses using a monoclonal antibody and a method for preparing the monoclonal antibody. A hybridoma cell line that produces a monoclonal antibody against the NSs proteins of WSMoV-serogroup tospoviruses was produced. The hybridoma cell line produces a monoclonal antibody binding with peptide SEQ ID No. 19. | 2009-11-05 |
20090275014 | THERMAL CYCLING METHOD - This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so as to have temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. | 2009-11-05 |
20090275015 | NON-INVASIVE RESPIRATORY RAPID DIAGNOSIS METHOD - A non-invasive method for rapidly determining the specific presence or absence of respiratory pathogens and chemical entities. | 2009-11-05 |
20090275016 | ARRAYED DETECTOR SYSTEM FOR MEASUREMENT OF INFLUENZA IMMUNE RESPONSE - A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein. | 2009-11-05 |
20090275017 | Novel Nucleoside or Nucleotide Derivative and Use Thereof - The object of the present invention is to provide a nucleoside or nucleotide having a 5-substituted-2-oxo(1H)pyridin-3-yl group as a base, as well as a method using the same. | 2009-11-05 |
20090275018 | Detection of hepatotoxic cyanobacteria - The present invention relates to methods and kits for the detection of toxic cyanobacteria, in particular of hepatotoxin-producing cyanobacteria. | 2009-11-05 |
20090275019 | Pancreatic Cancer Genes - The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia. | 2009-11-05 |
20090275020 | Traceability of Cellular Cycle Anomalies Targeting Oncology and Neurodegeneration - The present invention relates to the field of medicine and biology. It concerns a novel test for screening and for therapeutic follow-up in oncology. More particularly, it relates to diagnostic and/or therapeutic tests in oncology and on neurodegenerative diseases. It is a diagnostic test and a prognostic test for various cancers (breast cancer, bladder cancer, ovarian cancer, lung cancer, skin cancer, prostate cancer, colon cancer, liver cancer, gliboblastoma, sarcoma, leukemia, etc.) and therapeutics solutions for specific neurodegenerative diseases. More particularly, the invention concerns the use of the LIV21 protein, LIV21 gene and of derivatives thereof as diagnostic and prognostic markers for cancers. The invention therefore concerns the detection of the LIV21 protein with a kit comprising LIV21-specific antibodies. | 2009-11-05 |
20090275021 | NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS - Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same. | 2009-11-05 |
20090275022 | STAT6 EFFECTS ON LIVESTOCK ANIMAL GROWTH - The present invention provides for selection of livestock animals, including bovines, whose genotypes based in the STAT6 gene are correlated with phenotypes reflecting desirable carcass and feedlot traits. These phenotypes include back fat (BFAT), calculated yield grade (CALCYG), cutability (CUT), hot carcass weight (HCW), dry matter intake (DMI), days on feed (DOF), back fat rate (BFAT RATE) and average daily gain (ADG), based on the knowledge of the STAT6 genotypes. The predictive value is based in part on the discovery that certain single nucleotide polymorphisms (SNPs) within the STAT6 gene are linked to phenotypes of economically these important carcass and feedlot traits. Also provided are SNPs within the STAT6 gene useful in reliably distinguishing between a | 2009-11-05 |
20090275023 | Compositions and methods for detecting borrelia afzelii - Disclosed are oligonucleotides useful in methods for determining whether a sample contains | 2009-11-05 |
20090275024 | Novel centrerosome-associated protein and applications thereof - A method for diagnosing a genetic disease associated with disturbances in mitotic spindle organization or with cell division anomalies or both, which comprises demonstrating a functional alteration of the gene encoding an ASAP protein comprising at least the following steps of: obtaining DNA containing the gene encoding the ASAP protein from a biological sample; bringing said DNA into contact with a probe, and under conditions for hybridization between the DNA and the probe; and detecting the hybrid formed; and wherein the ASAP protein is selected from the group consisting of a human protein having sequence SEQ ID NO:1 and proteins having a sequence exhibiting at least 80% identity or at least 90% similarity with entire SEQ ID NO. 1. | 2009-11-05 |
20090275025 | HPV Detection and Quantification by Real-Time Multiplex Application - The present invention relates to amplification primers and detection probes, which are useful for the detection of human papillomaviruses (HPV), and more particularly of HPV, which can be oncogenic for the mucosal epithelia. The amplification and detection systems provided by the present invention are group-targeted systems, namely A5-, A6- A7-, and A9-targeted systems. The amplification and detection systems of the invention allow for an amplification of HPV in multiplex as well as for a real-time detection, whereby at least the thirteen HR HPV can be detected in a single-tube assay. The invention further allows for a reliable quantitation of HPV viral loads in real-time multiplex amplification. | 2009-11-05 |
20090275026 | Primer and Probe for Detection of Mycobacterium Intracellulare, and Method for Detection of Mycobacterium Intracellulare by Using the Primer and Probe - The present invention discloses an oligonucleotide which comprises a part or the entire sequence of the nucleotide sequence shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8, or a part or the entire sequence of a sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8, wherein the oligonucleotide is capable of hybridizing with a nucleotide sequence of | 2009-11-05 |
20090275027 | Medium scale intergration of molecular logic gates in an automaton - Compositions and methods for optically detecting the presence of a plurality of oligonucleotides in a sample, wherein each oligonucleotide to be detected comprises consecutive nucleotides having a sequence different than the remaining oligonucleotides of the plurality are provided. | 2009-11-05 |
20090275028 | METHOD OF DETECTING TARGET NUCLEIC ACID - The present invention provides a method of detecting a target nucleic acid which includes a step of examining whether a washing step has been normally conducted. In an aspect of the invention, a monitoring nucleic acid probe to monitor the washing level is used. The probe shows a change in signal intensity by washing at a washing temperature changed in the optimum temperature range for washing the target nucleic acid and in a temperature range in the vicinity of the optimum temperature range for washing. | 2009-11-05 |
20090275029 | Systems and Methods to Quantify and Amplify Both Signaling and Probes for CDNA Chips and Gene Expression Microarrays - The invention provides a series of reagent compositions and methods for making and amplifying novel cDNA based probe sets from RNA samples to improve analysis with gene expression arrays. The methods globally produce probe sets with common universal linkers at one or both ends, called WRAP-Probes, wherein the linkers do not bind to the target sequences and they can efficiently bind added reporters to the probes. The universal linkers are also designed as primer binding sites for copying and amplifying the probes, either linearly with one linker, or exponentially with double linkers. The capacity to globally and exponentially amplify the probe set by PCR is a primary advantage. Adding reporters by terminal linkers also improves quantification since each probe gets equivalent signaling. The invention allows expression analysis of small research, clinical and forensic samples to enable improved diagnostics, drug discovery, therapeutic monitoring, and medical, agricultural and general research. | 2009-11-05 |
20090275030 | CELL CALCIFICATION SUPPRESSING PROTEINS, AND GENES OF THE PROTEINS - This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and then the expression of a protein encoded by such gene (herein referred to as “C-11 protein”) has been confirmed. Further, it has been discovered that when the c-erg or C-11 gene is introduced into osteoblasts, the calcification of the cells is inhibited. | 2009-11-05 |
20090275031 | Biomolecular nano device - Methods for measuring environmental parameters using chemical recording are provided. In some embodiments, the methods include generating a polymer comprising an ordered series of chemical units, wherein the position and number of each chemical unit in the polymer is indicative of a reading of the environmental state variable at a given point in time. The presently disclosed subject matter also provides compositions that can be employed in and/or that employ the disclosed methods for recording environmental state variables. | 2009-11-05 |
20090275032 | Reprogramming a cell by inducing a pluripotent gene through use of an HDAC modulator - The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the activity of an HDAC with an HDAC inhibitor and inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In still another embodiment, the invention relates to a method for reprogramming comprising exposing a cell to more than one agent to inhibit more than ore type of regulatory protein. In yet another embodiment, the invention relates to a reprogrammed cell or an enriched population of reprogrammed cells that can have characteristics of an ES-like cell, which can be re- or trans-differentiated into various differentiated cell types | 2009-11-05 |
20090275033 | Uses of BNIPXL-Beta in premature canities - The present invention concerns the use of a polypeptide comprising a sequence having at least 90% identity with all or part of BNIPXLβ, for cosmetic or therapeutic applications, in the treatment or prevention of premature canities in humans, said portion comprising at least 30 amino acids, as well as the use, for the same purpose, of a molecule comprising a RNAi sequence having at least 90% identity with all or part of the cDNA sequence of BNIPXLβ, said part comprising at least 18 nucleotides. | 2009-11-05 |
20090275034 | TEMPERATURE CONTROL SYSTEM - Single molecule technologies generally require sensitive optical detection and the ability to operate at multiple temperatures simultaneously in different parts of the instrument. The system for controlling the temperature of a microfluidic device and methods for controlling the temperature of sequencing reactions includes a chamber for receiving a microfluidic device, a heating control device in fluid communication with the chamber for delivering a heated fluid to the chamber to heat the microfluidic device, and a cooling control device in liquid communication with the chamber for delivering a cooled fluid to the chamber to cool the microfluidic device. A temperature control unit in liquid communication with a cooling element and/or a heating element are used to regulate temperature of sequencing substrates and objective lenses for optical detection of sequencing reactions. | 2009-11-05 |
20090275035 | PRIMERS FOR HUMAN MITOCHONDRIAL HYPERVARIABLE REGION AND METHOD FOR DETECTING HUMAN DNA BY USING THE PRIMERS - The present invention relates to primer pairs for human mitochondrial hypervariable region and a method for detecting human DNA by using the primer pairs. | 2009-11-05 |
20090275036 | SYSTEMS AND METHODS FOR REAL TIME SINGLE MOLECULE SEQUENCE DETERMINATION - A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system. | 2009-11-05 |
20090275037 | FLUORESCENT DOUBLE STRANDED DNA BINDING DYES - The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C-atom and (ii) the 5- and 6-positions of the pyrimidine ring are an integral part of a further aromatic ring structure. | 2009-11-05 |
20090275038 | METHOD AND APPARATUS FOR FORENSIC SCREENING - This invention relates to methods and system for forensic screening. More specifically, this invention relates to various methods to detect or screen for at least one designated genetic sequences in a plurality of biological sample | 2009-11-05 |
20090275039 | METHODS FOR DETECTION AND QUANTIFICATION OF SMALL RNA - Disclosed are methods, kits, and components for detecting small RNA molecules, such as microRNA and siRNA, in a sample. The methods utilize primers and reporter molecules comprising non-natural bases. The disclosed kits may include one or more components for performing the disclosed methods. | 2009-11-05 |
20090275040 | DETECTING BCL-B EXPRESSION IN CANCER AND USES THEREOF - Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer. | 2009-11-05 |
20090275041 | NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 193P1E1B USEFUL IN TREATMENT AND DETECTION OF CANCER - A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization. | 2009-11-05 |
20090275042 | Method of Detecting and/or Quantifying Expression of a Target Protein Candidate in a Cell, and a Method of Identifying a Target Protein of a Small Molecule Modulator - The present invention relates to a method of detecting and/or quantifying expression of a target protein candidate in a cell, and to a method of identifying a target protein of a small molecule modulator. | 2009-11-05 |
20090275043 | Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus - Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes. | 2009-11-05 |
20090275044 | METHOD FOR DETECTING HUMAN PAPILLOMAVIRUS mRNA - An in vitro method is provided for screening human female subjects to assess their risk of developing cervical carcinoma which comprises screening the subject for expression of mRNA transcripts from the E6 and optionally the L1 gene of human papillomavirus, wherein subjects positive for expression of L1 and/or E6 mRNA are scored as being at risk of developing cervical carcinoma. Kits for carrying out such methods are also provided. | 2009-11-05 |
20090275045 | METHOD FOR DETECTING MAMMARY CANCER CELLS - The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence in human mammary cancer tissue (or cells), (2) measuring an expression level of the gene in human normal mammary gland tissue (or cells), and (3) detecting mammary cancer cells on the basis of the difference between measurement values obtained in (1) and (2). | 2009-11-05 |
20090275046 | Complement factor H protein as a biomarker of Parkinson's disease - The present invention relates to a Complement Factor H protein as a biomarker for neurodegenerative disease, including Parkinson's disease, and the related diseases. More specifically, the present invention relates to the identification of a Complement Factor H protein, useful for the screening, diagnosis, and differentiation between neurodegenerative diseases. | 2009-11-05 |
20090275047 | CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLATE CYCLASE - The invention provides the crystal structure of the solAC catalytic domain. The structure is set out in Tables 1 to 5. The structure may be used in to model the interaction of ligands such as pharmaceutical compounds with this protein, and to determine the structure of related adenylate cyclase molecules. | 2009-11-05 |
20090275048 | ANTI-ACHARAN SULFATE ANTIBODY AND ITS APPLICATION - An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan sulfate. | 2009-11-05 |
20090275049 | EphA4 POLYPEPTIDE HAVING A NOVEL ACTIVITY AND USE THEREOF - The present invention provides a polynucleotide which consists of a partial sequence of a polynucleotide encoding the amino acid sequence as shown in SEQ ID NO: 2, wherein the former polynucleotide encodes a polypeptide consisting of a partial amino acid sequence of SEQ ID NO: 2 whose N-terminus starts between positions 564 and 621 of SEQ ID NO: 2. | 2009-11-05 |
20090275050 | 14273 receptor, a novel G-protein coupled receptor - The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides. | 2009-11-05 |
20090275051 | LUMINOGENIC AND NONLUMINOGENIC MULTIPLEX ASSAY - A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided. | 2009-11-05 |
20090275052 | ADJUSTABLE MOLECULAR MOTOR MICROPOWER BIOSENSOR AND ITS APPLICATION - A regulable molecular motor micropower biosensor comprises: a rotary motor, an optical energy conversion device, a signal molecular output device, a power resource system, a protective layer, a supporting material, and a bilayer lipid membrane fixing material. The molecular motor micropower biosensor is used for detecting biological macromolecules, viral molecules, etc. | 2009-11-05 |
20090275053 | CELL-BASED PCSK9 SCREENING ASSAY - The present invention includes a PCSK9 activity inhibition assay system, kits, compositions and methods. The present invention includes a cell having a first vector capable of expressing a catalytic fragment of PCSK9, a second vector capable of expressing a prodomain of PCSK9 and a V5 protein with a detectable label. The V5 protein forms a fusion protein with the prodomain of PCSK9 and wherein cleavage of the prodomain by the catalytic fragment of PCSK9 releases a detectable signal. | 2009-11-05 |
20090275054 | Pancreatic Cancer Genes - The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia. | 2009-11-05 |
20090275055 | Monoclonal Antibodies Specific to Denatured Human Class I Leucocyte Antigens - [PROBLEMS] To provide a monoclonal antibody simultaneously detectable the expression of all three kinds of HLA-A, HLA-B and HLA-C heavy chain proteins composing human class I leukocyte antigens (HLA class I) in denatured human tissue samples fixed by formalin and the like. | 2009-11-05 |
20090275056 | Methods for obtaining antibodies - The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is used in conjunction with a polyclonal antibody to isolate cells recognizing said antigen. | 2009-11-05 |
20090275057 | Diagnostic markers predictive of outcomes in colorectal cancer treatment and progression and methods of use thereof - Colorectal cancer patients with operable tumors must decide whether to receive adjuvant therapy after surgical resection in order to reduce their chances of recurrence. Current clinical guidelines are crudely based on the stage of the disease, as well as a few other clinicopathologic features. The instant invention integrates data from these clinicopathologic features with data on multiple biomarkers using advanced informatic methods to provide a far more accurate prediction of recurrence than the current guidelines. The instant invention consists of a panel of biomarker assays plus an algorithm into which the scored biomarker data, as well as standard clinicopathologic data, is entered. A tumor sample from an individual patient is submitted for test, and an individualized report is produced with a prognostic score that accurately reflects the patient's risk of recurrence. This helps guide the patient and his/her oncologist in their choice of whether to receive adjuvant treatment. Low-risk patients are spared the unnecessary toxicities associated with cytotoxic treatments, and high-risk patients are given the best chance for a cure, maximizing both life expectancy and quality of life. | 2009-11-05 |
20090275058 | METHOD FOR SPECIFIC DETECTION OF SALMONELLA SPP. - A method for specific detection of the presence of | 2009-11-05 |
20090275059 | Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same - Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen α-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800, and a protein which is an apolipoprotein AI decomposition product and has a molecular weight of 28,000, each showing an increase or a decrease with the habit of drinking, are newly found out. By detecting or quantifying these proteins, a liver disease in a subject such as one having a problem of drinking can be diagnosed at the early stage. | 2009-11-05 |
20090275060 | DETERMINATION OF SERUM ANTI-MULLERIAN HORMONE AS A DIAGNOSTIC TEST FOR SPAY IN COMPANION ANIMALS - This invention relates to non-surgical assays that can be used to determine whether an animal that has a non-postpartum anestrous period of three months or greater, such as a dog or a cat, has been spayed. In particular, the present invention relates to devices, kits and methods that allow correlation of levels of Anti-Müllerian Hormone with the state of being spayed. | 2009-11-05 |
20090275061 | METHOD TO MEASURE SERUM BIOMARKERS FOR THE DIAGNOSIS OF LIVER FIBROSIS - This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different liver fibrosis-associated serum biomarkers in a serum sample, which can be used for the diagnosis of liver fibrosis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of liver fibrosis-associated serum biomarkers for the diagnosis of liver fibrosis. | 2009-11-05 |
20090275062 | METHOD OF TACROLIMUS EXTRACTION AND QUANTIFICATION USING AQUEOUS DETERGENTS - The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumbersome manual pretreatment procedures or the use of organic solvents. The method of the present invention permits full automation of tacrolimus quantification assays. | 2009-11-05 |
20090275063 | Distinguishing cells in a sample by inactivating extracellular enzyme before releasing intracellular enzyme - A method for detecting the absence or presence of cells of interest in a liquid sample, wherein: (a) the sample: (i) comprises an extracellular medium containing an enzyme with a measurable activity; and (ii) is suspected of containing cells of interest that contain an enzyme with said measurable activity; and (b) the method comprises the steps of: (i) treating the liquid sample with a reagent that inactivates said measurable activity in the extracellular medium, but does not inactivate the measurable activity in said cells of interest; (ii) lysing the cells of interest to release the intracellular enzyme; and (iii) measuring said measurable activity. Thus the intracellular enzyme can be measured without interference from the extracellular enzyme. The invention is particularly useful for treatment of bacterially-infected blood using a detection assay based on adenylate kinase activity. | 2009-11-05 |
20090275064 | Methods to identify therapeutic agents - As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic attractants of macrophages, can promote differentiation of monocytes into macrophages and can increase expression of E-selectin and Class A scavenger receptor (SR-A). The present application is directed to methods of using such cholesterol ozonation products to identify agents that can be used to treat atherosclerosis and other inflammatory artery diseases. | 2009-11-05 |
20090275065 | METHODS AND COMPOUNDS FOR DETECTING BETA-LACTAMASE ACTIVITY - The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z-R | 2009-11-05 |
20090275066 | IMMOBILIZATION OF MEMBRANE PORTEINS ONTO SUPPORTS VIA AN AMPHIPHILE - The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane protein is complexed. It also relates to a process for preparing such product, as well as to various applications in the fields of diagnosis, drug design and biotechnologies. It further relates to a kit, together with a functionalized amphiphilic molecule, for preparing a product according to the invention comprising a support and an amphiphilic molecule, wherein the amphiphilic molecule and the support interact through a hydrophobic bond, an ionic bond, a specific bond or a covalent bond. | 2009-11-05 |
20090275067 | METHOD OF ACQUIRING HEPATIC OVAL CELLS - Provided are a method of isolating and identifying hepatic oval cells from the liver, and a method of single cell culture of hepatic oval cells. A method of separating and/or acquiring hepatic oval cells from a mammal, comprising a step for examining the expression of CD133, CD45 and Ter119. Particularly, hepatic oval cells that exhibit the pattern of CD133 | 2009-11-05 |
20090275068 | Method of determining chymase activity with secretory leukocyte protease inhibitor - It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions. | 2009-11-05 |
20090275069 | Pancreatic Cancer Genes - The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia. | 2009-11-05 |
20090275070 | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators - This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost, reductions in the drug discovery process resulting from the corresponding increases in efficiency. | 2009-11-05 |
20090275071 | DIAGNOSTIC COMPOSITION AND ARTICLE FOR MONITORING INTRAVAGINAL INFECTIONS - The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the buffer capacities associated with vaginal secretions. The diagnostic composition provides a visible indication of vaginal infections, such as bacterial vaginosis. | 2009-11-05 |
20090275072 | In Vitro bio-reactor circuit - Embodiments of the invention provide bio-reactor circuits for in vitro research applications. One embodiment provides a bio-reactor circuit comprising at least one bio-reactor and a pump fluidically coupled to the at-least-one bio-reactor. The bio-reactor comprises a housing having inlet and outlet ports and first and second chambers. The chambers are separated by a porous membrane with the first chamber providing a flow path for a fluid. The membrane includes a coating having a cell binding affinity for the attachment and proliferation of cells to cover the surface of the membrane. The second chamber provides a volume for maintaining the viability of cells disposed in the chamber. The cells can be selected to produce a biochemical compound. The membrane is configured to allow for diffusion of the compound from the second chamber into the flow path as well as allow for diffusion of gases, nutrients and other biochemical compounds. | 2009-11-05 |
20090275073 | DIAGNOSIS DEVICE AND DIAGNOSIS METHOD - A diagnosis device includes: a pretreating portion configured to suspend tissue to obtain a suspension; and an analyzing portion configured to analyze the suspension. | 2009-11-05 |
20090275074 | System and Method for Performing G Protein Coupled Receptor (GPCR) Cell Assays Using Waveguide-Grating Sensors - The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells. | 2009-11-05 |
20090275075 | METHODS AND SYSTEMS FOR ENSURING THE SECURITY OF FOOD COMMODITIES - Aspects include claims, systems, and methods for testing food commodities, including without limitation bulk food commodity stores to identify the presence of contaminants. Such contaminants tested for may include biological, chemical, or radio nuclear material. Another aspect is marking and/or tracking food commodity stores that have been certified as either being contaminated or safe. Still another aspect is an automated or automatic system for measuring the level of contamination in a given food commodity store, and for marking and tracking food commodity stores tested for contamination. | 2009-11-05 |
20090275076 | CELL SAMPLE PREPARATION METHOD AND APPARATUS - An apparatus and method for automatic thin-layer cell sample slide preparation without requiring human intervention are disclosed. According to one embodiment, a cell sample is measured to derive a cell sample measurement. An estimation of total cellularity of the cell sample is determined based upon the cell sample measurement. A differential volume of diluent is dispensed to the cell sample based upon the estimation of total cellularity of the cell sample to form a cell suspension. In one embodiment, a differential volume of the cell suspension and a differential volume of cell adherent may be combined based upon the estimation of total cellularity of the cell sample to form a cell mixture. A differential volume of the cell suspension or cell mixture (if an adherent is mixed with the cell suspension) is dispensed onto a surface of a sample slide. | 2009-11-05 |
20090275077 | Methods of Obtaining Optically Active Epoxides and Vicinal Diols from Styrene Oxides - The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific meso-epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining | 2009-11-05 |
20090275078 | Alpha-Amylase Variants - The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular increased starch affinity relative to the parent alpha-amylase. | 2009-11-05 |
20090275079 | Novel genes encoding novel proteolytic enzymes - The invention relates to newly identified gene sequences that encode novel proteases obtainable from | 2009-11-05 |
20090275080 | Glucoamylase variants with altered properties - The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. | 2009-11-05 |
20090275081 | BIOTIN-LIGASE SYSTEM FOR SECRETION OF BIOTINYLATED PROTEIN - The present invention provides methods of metabolically biotinylating recombinant proteins. Cell lines and specific protein and nucleic acid constructs for use in the methods of the present invention are also provided herein. | 2009-11-05 |
20090275082 | Mast Cell-Derived Membrane Proteins - An originally developed efficient signal sequence trapping method was used to screen a cDNA library prepared from cultured mast cells derived from mouse bone marrow. As a result, genes encoding type I membrane proteins and comprising a single immunoglobulin domain in the extracellular domain and a motif for transmitting an inhibitory signal into cells were successfully isolated. | 2009-11-05 |
20090275083 | ISOLATED PEPTIDES HAVING PHOSPHOLIPASE INHIBITORY ACTIVITY - The invention provides for isolated peptides having phospholipase inhibitory activity, polypeptides comprising phospholipase inhibitory activity and lipases capable of being inhibited by the isolated peptides and/or polypeptides comprising phospholipase inhibitory activity. The invention also relates to nucleic acid constructs, recombinant expression vectors, and recombinant host cells comprising the polynucleotides as well as methods for producing and using the peptides and the polypeptides having lipase inhibitory activity. | 2009-11-05 |
20090275084 | LONG-ACTING EPO POLYPEPTIDES AND DERIVATIVES THEREOF AND METHODS THEREOF - A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an EPO peptide are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed. | 2009-11-05 |
20090275085 | Enzyme for Obtaining Prebiotic Oligosaccharides - An industrially viable process of obtaining prebiotic oligosaccharides using a new | 2009-11-05 |
20090275086 | ASSEMBLY OF LARGE NUCLEIC ACIDS - A method to assemble any desired nucleic acid molecule by combining cassettes in vitro to form assemblies which are further combined in vivo, or by assembling large numbers of DNA fragments by recombination in a yeast culture to obtain desired DNA molecules of substantial size is described. | 2009-11-05 |
20090275087 | ASYMMETRIC ADAPTER LIBRARY CONSTRUCTION - The present invention provides methods and compositions for asymmetrically tagging a nucleic acid fragment using asymmetric adapters. | 2009-11-05 |
20090275088 | PROCESSES FOR THE PREPARATION OF HIGHLY PURE PLASMID COMPOSITIONS - The present disclosure generally relates to processes for preparing highly pure plasmid compositions. The processes generally involve treating a composition comprising plasmid DNA with a polypeptide to digest colanic acid. The treated plasmid DNA is then separated from the treated composition. | 2009-11-05 |
20090275089 | Mutant Phosphoribosylpyrophosphate Synthetase and Method for Producing L-Histidine - The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant to feedback by purine nucleotides, coded by the mutant prsA gene. | 2009-11-05 |
20090275090 | L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-AMINO ACIDS - A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the β-glucoside PTS activity, and collecting the L-amino acid from the medium or cells. | 2009-11-05 |
20090275091 | L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-AMINO ACIDS - A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the mannose PTS activity, accumulating the L-amino acid in the medium or in cells, and collecting the L-amino acid from the medium or cells. | 2009-11-05 |
20090275092 | METHOD FOR PRODUCING 4-HYDROXY-L-ISOLEUCINE - A highly active L-isoleucine dioxygenase from | 2009-11-05 |
20090275093 | Biochemical Synthesis of 1,4-Butanediamine - The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein the increased ODC activity is obtained by means of overexpression of an ornithine decarboxylase encoding gene with increased translational and/or transcriptional efficiency, and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. In preferred embodiments also increased enzyme activity is obtained by of overexpression of either (i) an arginine decarboxylase encoding gene speA and an agmatinase encoding gene speB; or (ii) an arginine decarboxylase encoding gene speA and an agmatine iminohydrolase encoding gene aguA, and an N-carbamoylputrescine amidohydrolase encoding gene aguB, and optionally also an agmatinase encoding gene speB. The invention also relates to vectors, plasmids and hosts carrying, at an increased level of activity, one or more of the enzyme activities as mentioned. | 2009-11-05 |
20090275094 | PROCESS FOR PRODUCING SULFUR-CONTAINING HYDROXYCARBOXYLIC ACID - There is provided is a process for producing a sulfur-containing α-hydroxycarboxylic acid compound represented by the formula (2): | 2009-11-05 |
20090275095 | DNA Encoding a Protein Having a D-Lactate Dehydrogenase Activity and Uses Thereof - This invention provides a polynucleotide that encodes a protein having lactate dehydrogenase activity and such protein that can be used for producing D-lactic acid. This polynucleotide has the nucleotide sequence as shown in SEQ ID NO: 1 (a), and it hybridizes under stringent conditions with a probe comprising all or part of the nucleotide sequence as shown in SEQ ID NO: 1 or a complementary strand thereof and encodes a protein having D-lactate dehydrogenase activity (b). | 2009-11-05 |
20090275096 | MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID - The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. | 2009-11-05 |
20090275097 | PRIMARY ALCOHOL PRODUCING ORGANISMS - The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms. | 2009-11-05 |
20090275098 | SYSTEMS AND PROCESSES FOR ENHANCED YIELD FROM FERMENTATIONS THAT CONTAIN XYLOSE - A system and process for the utilization of xylose during fermentation is described. The system uses a fermenter and a separate reactor to isomerize the xylose to xylulose. The separation of the two processes allows the optimization of each process since the isomerization operates ideally in a calcium free environment near pH 7.5 while the fermentation operates ideally below a pH of 6. Control of pH is assisted by the modulation of CO2 in the fermentation medium. Xylulose is fermented to ethanol by numerous standard yeasts although other products are also possible. The separate reactor may be run in a single pass, or, more preferably in a recirculating mode to allow full isomerization while the xylulose product is being consumed by the yeast. A preferred embodiment includes a Simultaneous Saccharification and Fermentation system where the liquid portion of the fermenting broth is isomerized and returned to the fermentation vessel. | 2009-11-05 |
20090275099 | Methods and compositions for treating diseases and conditions associated with mitochondrial function - The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F | 2009-11-05 |
20090275100 | COMPOSITIONS AND METHODS FOR ENHANCED SENSITIVITY AND SPECIFICITY OF NUCLEIC ACID SYNTHESIS - The present invention relates to nucleic acid inhibitors, compositions and method for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses nucleic acids having affinity for polypeptides with polymerase activity for use in such synthesis, amplification or sequencing reactions. The nucleic acid inhibitors are capable of inhibiting nonspecific nucleic acid synthesis under certain conditions (e.g., at ambient temperatures). Thus, in a preferred aspect, the invention relates to “hot start” synthesis of nucleic acid molecules. Accordingly, the invention prevents, reduces or substantially reduces nonspecific nucleic acid synthesis. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the nucleic acid inhibitors or compositions of the invention. The invention also relates to using the inhibitors of the invention to prevent viral replication or treat viral infections in a subject. Thus, the invention relates to therapeutic methods and pharmaceutical compositions using the inhibitors of the invention. The invention thus may be used for in vivo and in vitro inhibition of nucleic acid synthesis and/or inhibition of polymerase activity. | 2009-11-05 |
20090275101 | Pancreatic Cancer Genes - The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia. | 2009-11-05 |
20090275102 | EHRLICHIA DISULFIDE BOND FORMATION PROTEINS AND USES THEREOF - Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from | 2009-11-05 |
20090275103 | Recombinant hexose oxidase - Use of a preparation as an antimicrobial agent or as an anti-oxidant; wherein said preparation comprises a polypeptide having hexose oxidase activity, the polypeptide being in a substantially pure form, and said polypeptide comprises at least one amino acid sequence selected from the group consisting of | 2009-11-05 |
20090275104 | Bacillus licheniformis chromosone - The present invention relates to an isolated polynucleotide of the complete chromosome of | 2009-11-05 |
20090275105 | PROCESS FOR THE PRODUCTION OF BROMELAIN BY MEANS OF SUBSTANCES THAT INDUCE PROTEINS IN PINEAPPLE PLANTS - Provided are methods of producing, via induction, plant products such as bromelain from plants of the genus | 2009-11-05 |
20090275106 | Polynucleotide encoding A polypeptide having heparanase activity and expression of same in genetically modified cells - A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression. | 2009-11-05 |