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44th week of 2011 patent applcation highlights part 48
Patent application numberTitlePublished
20110269934PRODUCTION METHOD AND APPARATUS FOR POLYTRIMETHYLENE TEREPHTHALATE - An object of the present invention is to provide a reasonable polycondensation step by which an appropriate molecular weight can be obtained and material decomposition associated with thermolysis can be suppressed, so as to contribute to production technology for PTT polymers. The production method for polytrimethylene terephthalate comprises an esterification step and a polycondensation step, wherein the polycondensation step is divided into multiple stages, polycondensation is performed using a polymerization vessel having a twin-shaft agitator in the final stage of the polycondensation step, and the polymerization temperature during the subsequent stage of the polycondensation step is less than the polymerization temperature during the former stage of the polycondensation step.2011-11-03
20110269935METHOD FOR PREPARING POLYARYLENE SULFIDE WITH REDUCED FREE IODINE CONTENT - The present invention relates to a method for preparing polyarylene sulfide with a reduced free iodine content. More specifically, the method for preparing polyarylene sulfide includes: (a) polymerizing reactants including a diiodo aromatic compound and a sulfur compound to form a polyarylene sulfide; and (b) maintaining the polyarylene sulfide product at 100 to 260° C. for heat-setting. The preparation method of the present invention effectively reduces the free iodine content of the polyarylene sulfide to prevent potential corrosion of facilities for the subsequent process and improves the properties of the polyarylene sulfide product such as thermal stability, so the method can be usefully applied to industrial fields in regard to the preparation of polyarylene sulfide.2011-11-03
20110269936Method for Producing Biocidal Polyguanidine, and Biocidal Polyguanidine - The inventions relate to antiseptic agents and the method for producing thereof and can be used as a broad-spectrum disinfectant in medicine, veterinary medicine, agriculture etc.2011-11-03
20110269937Conserved-Element Vaccines and Methods for Designing Conserved-Element Vaccines - Embodiments of the present invention include conserved-element vaccines and methods for designing and producing conserved-element vaccines. A conserved-element vaccine (“CEVac”) is a recombinant and/or synthetic vaccine that incorporates only highly conserved epitopes from an observed set of pathogen variants. The conserved epitopes are identified computationally by aligning biopolymer sequences, such as concatenated polypeptide sequences that together represent a pathogen proteome, corresponding to an observed set of pathogen variants, and computationally selecting conserved subsequences according to a number of subsequence-selection criteria. These subsequence-selection criteria may include a minimum conserved-subsequence length, a threshold frequency of occurrence of a particular monomer at each conserved, single-monomer position within a conserved subsequence, a threshold combined occurrence for a set of allowable variant monomers at a particular conserved, variable position within a conserved subsequence, and a maximum number of variable positions within a subsequence. A set of conserved subsequences identified according to the subsequence-selection criteria are then filtered to remove subsequences identical to, or too similar to, naturally-occurring host subsequences, and are then assembled into expression vectors for incorporation into microbial hosts for biosynthesis of a recombinant CEVac or assembled into one or more synthetic constructs for a synthetic CEVac.2011-11-03
20110269938AMYLOID-BETA PEPTIDE CRYSTAL STRUCTURE - The invention relates provides a novel crystal structure of the fibrillogenic part of amyloid β-peptide (Aβ). More specifically the crystal structure is Aβ-IgNAR and, accordingly the present invention also relates to selecting and/or designing compounds that modulate amyloid β-peptide (Aβ) activity using techniques such as in silico screening and crystal soaking experiments. The invention further relates to compounds and methods for inhibiting interaction between amyloid β-peptide (Aβ) monomers, more particularly, inhibiting or disrupting amyloid β-peptide (Aβ) oligomer formation and toxic activity.2011-11-03
20110269939NEW APPROACH FOR DESIGNING DIABETES DRUGS - The present technology relates to the fields of crystallography, biochemistry, and drug design. In particular, methods and compositions for screening, identifying and designing compounds that interact with human mitoNEET.2011-11-03
20110269940Self-Assembled Proteins and Related Methods and Protein Structures - The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences that transcribe peptide sequences that form links between proteins, where the peptide sequences produce a hook or loop which supports specific self-assembly of homo-dimers, hetero-dimers and multimers of the proteins to which they are attached. The hook or loop may have a short aliphatic repeat sequence and a metal binding loop. The present invention also provides a method of constructing a hook motif of metal binding loop sequences that may be attached to at least one aliphatic repeat sequence to produce the assemblages of proteins. Also provided are protein structures produced by the methods of the present invention.2011-11-03
20110269941METHOD OF LOADING A CRYSTALLIZATION DEVICE - The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby, pre-filled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.2011-11-03
20110269942ANTIBODIES MODIFIED WITH HYDROPHOBIC MOLECULE - The present invention relates to an immunoliposome preparation or a hydrophobic molecule-modified antibody having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome or a hydrophobic molecule-modified antibody comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.2011-11-03
20110269943RADIOLABELED ANNEXINS - Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.2011-11-03
20110269944HGF PRECURSOR PROTEIN VARIANT AND ACTIVE PROTEIN THEREOF - An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.2011-11-03
20110269945FLUORESCENT PROTEIN - An object of the present invention is to provide a novel fluorescent protein derived from 2011-11-03
20110269946PROTEIN SEPARATION DEVICE - The invention provides a protein separation device comprising a chaperone protein immobilized on a substrate. In one embodiment, the chaperone protein is an Hsp60 chaperone, preferably a group one chaperone, preferably GroEL. The invention also provides a method for isolating a protein from a biological sample using a protein separation device of the invention.2011-11-03
20110269947APO-2 LIGAND/TRAIL FORMULATIONS - The present invention relates generally to Apo2L/TRAIL purification involving crystallization.2011-11-03
20110269948Method for Identifying Compounds for Cancer Therapy - The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression.2011-11-03
20110269949METHODS AND COMPOSITIONS TO ELICIT MULTIVALENT IMMUNE RESPONSES AGAINST DOMINANT AND SUBDOMINANT EPITOPES, EXPRESSED ON CANCER CELLS AND TUMOR STROMA - The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA2011-11-03
20110269950PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS - The present invention relates to a pharmaceutical composition comprising a modified mRNA that is stabilized by sequence modifications and optimised for translation. The pharmaceutical composition according to the invention is particularly well suited for use as an inoculating agent, as well as a therapeutic agent for tissue regeneration. In addition, a process is described for determining sequence modifications that promote stabilization and translational efficiency of modified mRNA of the invention.2011-11-03
20110269951siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CDKN1B.2011-11-03
20110269952COPPER PHTHALOCYANINE COMPOUNDS AND NEAR-INFRARED ABSORPTION FILTER USING THE SAME - A novel copper phthalocyanine compound with low absorptivity in the visible light region and high absorptivity in the near-infrared light region, and a near-infrared absorption filter using the same are disclosed. The near-infrared absorption copper phthalocyanine compound is represented by Formula 1 of Claim 2011-11-03
20110269953Nitrogen and Sulfur-Containing Heterocycle Derivatives - The present invention provides nitrogen and sulfur-containing heterocycle compounds to be used as scaffolds and, in particular, nitrogen and sulfur-containing heterocycle compounds having a thiomorpholine core. The compounds herein described may be useful in treating diseases such as diabetes, obesity, cancer, cardiovascular, Alzheimer's, inflammatory, antidepressant, rheumatoid arthritis, multiple sclerosis, allergic rhinitis, asthma as well as viral and bacterial infections. The compounds herein described may also be useful in treating CNS disorders such as but not limited to Schizophrenia, Alzheimer's disease (AD).2011-11-03
20110269954NOVEL THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF - The present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and the uses thereof. More specifically, the present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and a pharmaceutical composition comprising the same. The novel thiazolidinedione derivatives of formula (I) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins as well as useful for the prevention of hair loss and the stimulation of hair growth, and osteogenic stimulation and wound healing.2011-11-03
20110269955METHOD FOR PREPARING 2-MORPHOLINOISOBORNANE- 10-THIOL AND INTERMEDIATES FORMED THEREIN - A method for preparing 2-morpholinoisobornane-10-thiol is disclosed, which has simplified steps and avoids the use of Na metal. Accordingly, it is advantageous to apply the method in a mass production.2011-11-03
20110269956Hepatitis C Virus Inhibitors - The present disclosure relates to methods for making compounds useful in the treatment of Hepatitis C virus (HCV) infection.2011-11-03
20110269957SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 - Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).2011-11-03
20110269958PYRIDONS AS PDK1 INHIBITORS - The present invention encompasses compounds of general formula (1) while the groups R2011-11-03
20110269959PROCESS FOR THE PREPARATION OF PIPERAZINE DERIVATIVES - The invention relates to a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of general formula (I) by reacting the compound of formula (III) with a carbamoylchloride of general formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100° C. in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant.2011-11-03
20110269960TRIAZOLE DERIVATIVE - An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P2011-11-03
20110269961PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES - A method for preparing a compound of formula k2011-11-03
20110269962PROCESS FOR PREPARING STATINS - Process for the preparation of β-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin.2011-11-03
20110269963Preparation of Saturated Ketone Morphinan Compounds Having Low Metal Content - The present invention provides processes for the preparation of saturated ketone morphinan compounds from a morphinan comprising an allyl alcohol ring moiety, wherein the final product has a low metal content. In particular, the invention provides processes that utilize isomerization reactions catalyzed by transition metal catalysts and the subsequent removal of the transition metal using metal scavengers.2011-11-03
20110269964N-Alkylation of Opiates - The present invention provides an efficient process for preparing N-alkylated opiates. In particular, processes are provided for using a chloride-containing alkylating agent and a bromide or iodide salt to alkylate the corresponding nor-opiate.2011-11-03
20110269965Ring Closing and Related Methods and Intermediates - Methods and intermediates useful for making compounds of the formula: and the preparation of compounds of Formula I, preferably including the formation of intermediate compounds of the formula:2011-11-03
20110269966SEMICONDUCTING ARTICLES - An amic acid or amic ester precursor can be applied to a substrate and thermally converted into a thin organic semiconducting layer of the corresponding arylene diimide. This semiconducting layer can be used in various semiconductive articles such as organic light emitting diode (OLED), photodetector, sensor, logic circuit, memory element, capacitor, photovoltaic (PV) cell, or electronic devices. In this manner, the arylene diimide need not be coated but is generated in situ from a solvent-soluble and easily coated precursor compound.2011-11-03
20110269967AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS - Novel amic acids and amic esters can be thermally converted into corresponding arylene diimides. These amic acids and amic ester can be used as precursors to prepare semiconducting thin films that can be used in various articles including thin-film transistor devices that can be incorporated into a variety of electronic devices. In this manner, the arylene diimides need not be coated out of solvent in which they may be insoluble, but they can be generated in situ from a solvent-soluble, easily coated amic acid or amic ester.2011-11-03
20110269968Non-Signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters - Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-containing compounds simultaneously.2011-11-03
20110269969TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF - The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).2011-11-03
20110269970Phenethanolamine Derivatives for Treatment of Respiratory Diseases - (1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol and (5R)-3-(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one are claimed2011-11-03
20110269971PROCESS FOR PRODUCTION OF HYDROXYADAMANTANEAMINE - Disclosed is a process for producing 1-hydroxy-4-aminoadamantane.2011-11-03
20110269972NOVEL TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS - The present invention relates to a compound of general Formula (XX), its formation and its use in asymmetric catalysis. In Formula (XX) R and R2011-11-03
20110269973Process for Preparing Dithiine-tetracarboximides - The present invention relates to a new process for preparing dithiine-tetracarboximides.2011-11-03
20110269974Polymer Derivatives - The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.2011-11-03
20110269975NOVEL COMPOUNDS - The present invention related to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to novel salts thereof, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).2011-11-03
20110269976GLYCOL COMPOUND HAVING DIOXANE STRUCTURE AND METHOD FOR PRODUCING THE SAME - Disclosed is a glycol compound which is useful as a raw material and an intermediate for synthetic resins, additives for synthetic resins, medicines, cosmetics, food additives, surfactants and the like, further disclosed is a method for producing the compound.2011-11-03
20110269977METHOD FOR PRODUCING 2,6-DIOXABICYCLO-(3.3.0)-OCTANE-4,8-DIONE - The invention relates to a method for producing 2,6-dioxabicyclo-(3.3.0)-octane-4,8-dione (I), comprising the oxidation of dianhydrohexitols (II-IV), or of corresponding hydroxy ketones, with an oxygen-containing gas in the presence of a catalyst composition, the reaction proceeding without the addition of halogen sources.2011-11-03
20110269978Solvent-less Preparation of Polyols by Ozonolysis - Solvent-less methods to convert oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.2011-11-03
20110269979Preparation of Esters and Polyols by Initial Oxidative Cleavage of Fatty Acids Followed by Esterification Reactions - Methods to convert unsaturated fatty acids derived from biobased oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.2011-11-03
20110269980OLIGOMERIZED ESTER ALKOXYLATE COMPOSITIONS - A process results in oligomerized ester alkoxylate compositions having substantially no unsaturation, which may be useful as lubricants, heat transfer fluids, plasticizers, thickening agents, surfactants, or power transmission fluids. The steps include, in either order, oligomerization of a hydroxylated fatty acid or fatty ester and quantitative reaction of unreacted carboxylic acid or ester groups with an alcohol, with the product of either reaction then being alkoxylated in the presence of a double metal cyanide catalyst. These oligomerized ester alkoxylates may be derived from vegetable oils to ensure high levels of renewable carbons. The compositions may exhibit desirably high viscosity index, low pour point, and high levels of renewable carbons.2011-11-03
20110269981Pre-Esterification Of Primary Polyols To Improve Solubility In Solvents Used In The Polyol Process - Methods to pre-esterify primary polyols used in converting biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols.2011-11-03
20110269982USE OF FATTY ACIDS AS FEED MATERIAL IN POLYOL PROCESS - Methods to convert fatty acids to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.2011-11-03
20110269983PRODUCTION OF VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS IN OILSEED PLANTS - Oilseed plants which have been transformed to produce very long chain polyunsaturated fatty acids, recombinant constructs used in such transformations, methods for producing such fatty acids in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.2011-11-03
20110269984Acetylene storage using metal-organic frameworks of the formula M2(2,5-dihydroxyterephthalate) - This invention provides, but is not limited to, methods of using metal-organic frameworks (MOFs) having repeat units of the formula M2011-11-03
20110269985ISOTOPICALLY LABELED COMPOSITIONS AND METHOD - Compounds having stable isotopes 2011-11-03
20110269986AMIDES OF CREATNE, METHOD OF THEIR PREPARATION, AND REMEDY POSSESSING A NEUROPROTECTIVE ACTIVITY - The invention relates to pharmaceutical chemistry notably to new biologically active substances (BAS) and their properties. In particular, the invention relates to Creatine derivatives having a general formula: NH═C(NH2011-11-03
20110269987 Process for Preparation of Hexadecyl Cis-9-Tetradecenoate and Hexadecyl Cis-10-Tetradecenoate - Hexadecyl cis-9-tetradecenoate commonly known as Cetyl myristoleate (CMO) is being used for the treatment of osteoarthritis and other joint inflammatory diseases, cis-9-Tetradecenoic acid (cis-9-myristoleic acid) is the main precursor for the preparation of CMO. As there are limited natural plant sources for cis-9-tetradecenoic acid, the present invention aimed at the synthesis of cis-9-tetradecenoic acid methyl ester from oleic acid methyl ester. As oleic acid is not available in pure form, this has to be isolated from oleic acid-rich oils like olive oil. cis-10-Tetradecenoic acid methyl ester, an isomer of cis-9-tetradecenoic acid was also prepared from undecenoic acid methyl ester, a derivative of castor oil. Undecenoic acid is easily available commercially in pure form. Hexadecyl cis-9-tetradecenoate and hexadecyl c/s-10-tetradecenoate were prepared by enzymatic transesterification of cis-9-tetradecenoic acid methyl ester and cis-10-tetradecenoic acid methyl ester with 1-hexadecanol (cetyl alcohol) respectively. Both the isomers of cetyl myristoleate were evaluated for anti arthritis, blocking inflammation and reduction of adjuvant-induced arthritis in rats.2011-11-03
20110269988PROCESS FOR REMOVING ACETONE FROM A STREAM COMPRISING ACETONE, METHYL ACETATE AND METHYL IODIDE - The present invention relates to a separation process for removing acetone from a mixture comprising acetone, methyl acetate and methyl iodide, said process comprising the steps of: (a) introducing said stream comprising acetone, methyl acetate and methyl iodide into a first distillation zone; (b) introducing acetic acid into said first distillation zone, either by addition of acetic acid to said stream comprising acetone, methyl acetate and methyl iodide or by introduction of acetic acid directly to the first distillation zone at one or more points at or above the point of introduction of said stream comprising acetone, methyl acetate and methyl iodide into the first distillation zone in step (a), or a combination of both; (c) removing from the first distillation zone an overhead stream comprising methyl iodide and a bottoms stream comprising acetone, methyl acetate, acetic acid, and a reduced amount of methyl iodide; (d) introducing into a second distillation zone the bottoms stream from step (c); (e) removing from the second distillation zone an overhead stream comprising methyl acetate and methyl iodide and a bottoms stream comprising acetone, methyl acetate and acetic acid; (f) introducing the bottoms stream from step (e) into a third distillation zone; and (g) removing from the third distillation zone an overhead stream comprising methyl acetate and acetone and a bottoms stream comprising methyl acetate and acetic acid.2011-11-03
20110269989METHOD OF MAKING ALKYLENE GLYCOLS - A method for halogenating, sulfonating, or sulfo-halogenating a feed comprising paraffin, by subjecting a mixture comprising the feed and a reagent selected from the group consisting of sulfonating agents, halogenating agents, and combinations thereof to a shear rate of at least 20,000 s2011-11-03
20110269990PROCESS FOR PRODUCING PERFLUOROALKYLSULFONIC ACID SALT - In this method for producing a perfluoroalkylsulfonic acid salt, there is provided a method for producing a perfluoroalkylsulfonic acid salt with a low fluorine content, which is a simple method to achieve a high yield,2011-11-03
20110269991PURE CARBOXYLIC ACID FILTRATION - The present invention relates to a process for production of pure terephthalic acid comprising: a) removing a mother liquor from a terephthalic acid through a filter with a gas, wherein the gas comprises steam at a concentration of least about 50% by volume; b) purifying the gas; and c) recycling the gas purified in step (b) back to step (a).2011-11-03
20110269992Preparation of acetic acid and acetic anhydride - Disclosed is a process for the preparation of acetic acid and acetic anhydride. The process comprises carbonylating dimethyl carbonate. The carbonylation reaction for producing acetic acid is performed in the presence of water, while the carbonylation for producing acetic anhydride is performed essentially in the absence of water.2011-11-03
20110269993PROCESSES FOR PRODUCING ADIPIC ACID FROM FERMENTATION BROTHS CONTAINING DIAMMONIUM ADIPATE - Processes for making AA from either a clarified DAA-containing fermentation broth or a clarified MAA-containing fermentation broth that include distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that comprises water and ammonia, and a liquid bottoms that includes AA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure AA; and separating the solid portion from the liquid portion. A method also reduces the broth distillation temperature and pressure by adding an ammonia separating and/or water azeotroping solvent to the broth.2011-11-03
20110269994METHOD OF PRODUCING A TRIARYLAMINE COMPOUND - A production method of a triarylamine compound including: producing a particular triarylamine compound by performing a reaction between a specific halogenated triarylamine compound and a specific olefin in the presence of palladium and alkylphosphine.2011-11-03
20110269995REACTOR AND PROCESS FOR PREPARING PHOSGENE - A reactor (2011-11-03
20110269996PROCESS FOR PREPARING KETONES BY REACTING 1,1-DISUBSTITUTED OLEFINS WITH N2O - The present invention relates to a process for preparing a ketone, comprising the reaction of a composition (I) at least comprising a 1,1-disubstituted olefin, with a composition comprising dinitrogen monoxide, wherein the reaction is effected in the presence of a solvent which comprises at least one proton-donating functional group.2011-11-03
20110269997Process of Controlling Heavies in a Recycle Catalyst Stream - A process of controlling heavies in a recycle catalyst stream, particularly, for use in a continuous hydroformylation process of converting an olefin with synthesis gas in the presence of a hydroformylation catalyst to form an aldehyde product stream with subsequent separation of the catalyst for recycle to the hydroformylation step. Heavies are controlled, and preferably reduced, by means of feeding a recycle gas stream, taken as a portion of an over-head stream from a condenser, back to a vaporizer wherein the aldehyde product stream is separated.2011-11-03
20110269998 PROCESS FOR OXIDATION ON FIXED CATALYTIC BED OF METHANOL TO FORMALDEHYDE - A process for the fixed bed oxidation of methanol to formaldehyde wherein the bed comprises at least two layers having different catalytic activity, wherein the layer of lower activity is comprised in the part of the bed from which the reactant gas mixture enters and its activity is calibrated so that the maximum hot spot temperature in the layer is comprised between 350° C. and 430° C. and is higher than the maximum hot spot temperature of the layer of greater activity formed by pure catalyst, and wherein during the period in which the situation of the maximum hot spot temperature of the layer of lower activity remains at the values cited above, the conversion of methanol is higher than 96% by mols.2011-11-03
20110269999PROCESS FOR DEHYDROHALOGENATION OF HALOGENATED ALKANES - A process for the manufacture of halogenated olefins in semi-batch mode by dehydrohalogenation of halogenated alkanes in the presence of an aqueous base such as KOH which simultaneously neutralizes the resulting hydrogen halide. During the process, aqueous base is continuously added to the haloalkane which results in better yields, lower by-product formation and safer/more controllable operation.2011-11-03
20110270000METHOD FOR PRODUCING TETRAFLUOROPROPENES - The current invention relates to a process for making a tetrafluoropropene using a tetrafluorochloropropane and/or a pentafluoropropane as starting or intermediate reagents. More specifically, though not exclusively, the present invention relates to a novel method for preparing a tetrafluoropropene by dehydrohalogenating a starting or intermediate tetrafluorochloropropane and/or pentafluoropropane material in the presence of a caustic solution at a temperature range greater than 40° C. and less than or equal to 80° C.2011-11-03
20110270001Method of Purifying (Z)-1-Chloro-3,3,3-Trifluoropropene - Disclosed is a method of purifying (Z)-1-chloro-3,3,3-trifluoropropene of the formula [1], comprising: distilling a mixture containing (Z)-1-chloro-3,3,3-trifluoropropene and 1-chloro-1,3,3,3-tetrafluoropropane (CF2011-11-03
20110270002CATALYST FOR PRODUCING MONOCYCLIC AROMATIC HYDROCARBONS, AND METHOD FOR PRODUCING MONOCYCLIC AROMATIC HYDROCARBONS - A catalyst for producing monocyclic aromatic hydrocarbons, used for producing monocyclic aromatic hydrocarbons of 6 to 8 carbon number from a feedstock oil having a 10 volume % distillation temperature of at least 140° C. and an end point temperature of not more than 400° C., wherein the catalyst contains a crystalline aluminosilicate, gallium and/or zinc, and phosphorus, the molar ratio between silicon and aluminum (Si/Al ratio) in the crystalline aluminosilicate is not more than 100, the molar ratio between the phosphorus supported on the crystalline aluminosilicate and the aluminum of the crystalline aluminosilicate (P/Al ratio) is not less than 0.01 and not more than 1.0, and the amount of gallium and/or zinc is not more than 1.2% by mass based on the mass of the crystalline aluminosilicate.2011-11-03
20110270003ZONE REACTOR INCORPORATING REVERSIBLE HYDROGEN HALIDE CAPTURE AND RELEASE - An improved process and a zone reactor for converting a hydrocarbon feedstock into higher hydrocarbons is provided. A first zone in the reactor contains both a material capable of releasing hydrogen halide (HX) and a carbon-carbon coupling catalyst; a second zone is initially empty or contains a halogenation and/or oxyhalogenation catalyst; and a third zone contains both a carbon-carbon coupling catalyst and a material capable of capturing HX. Air or oxygen is introduced into the first zone, a feedstock is introduced into the second zone, and products are produced in the third zone. HX produced during the reaction is reversibly captured and released in zones 2011-11-03
20110270004CATALYST FOR PRODUCING MONOCYCLIC AROMATIC HYDROCARBONS, AND METHOD FOR PRODUCING MONOCYCLIC AROMATIC HYDROCARBONS - A catalyst for producing monocyclic aromatic hydrocarbons of 6 to 8 carbon number from a feedstock oil having a 10 volume % distillation temperature of at least 140° C. and an end point temperature of not more than 400° C., or a feedstock oil having a 10 volume % distillation temperature of at least 140° C. and a 90 volume % distillation temperature of not more than 360° C., wherein the catalyst contains a crystalline aluminosilicate, gallium and/or zinc, and phosphorus, and the amount of phosphorus supported on the crystalline aluminosilicate is within a range from 0.1 to 1.9% by mass based on the mass of the crystalline aluminosilicate; and a method for producing monocyclic aromatic hydrocarbons, the method involving bringing a feedstock oil having a 10 volume % distillation temperature of at least 140° C. and an end point temperature of not more than 400° C., or a feedstock oil having a 10 volume % distillation temperature of at least 140° C. and a 90 volume % distillation temperature of not more than 360° C., into contact with the above-mentioned catalyst for producing monocyclic aromatic hydrocarbons.2011-11-03
20110270005METHOD FOR PRODUCING AROMATIC HYDROCARBONS - A method for producing aromatic hydrocarbons by bringing a feedstock derived from a fraction containing a light cycle oil produced in a fluid catalytic cracking into contact with a catalyst containing a crystalline aluminosilicate, wherein the proportion of the naphthene content within the feedstock is adjusted so as to be greater than the proportion of the naphthene content in the fraction containing the light cycle oil, and the contact between the feedstock and the catalyst is performed under a pressure within a range from 0.1 MPaG to 1.0 MPaG.2011-11-03
20110270006Use of an Additive in the Coupling of Toluene with a Carbon Source - A method is disclosed of preparing a catalyst, including contacting a substrate with at least one solution including a first promoter being Cs and at least one solution including a second promoter. The contact subjects the substrate to the addition of the first and second promoters, thereby forming the catalyst comprising the first and second promoters. In the method disclosed, the second promoter is capable of undergoing a redox reaction.2011-11-03
20110270007Catalyst with an Ion-Modified Binder - An alkylation catalyst having a zeolite catalyst component and a binder component providing mechanical support for the zeolite catalyst component is disclosed. The binder component is an ion-modified binder that can include metal ions selected from the group consisting of Co, Mn, Ti, Zr, V, Nb, K, Cs, Ga, B, P, Rb, Ag, Na, Cu, Mg, Fe, Mo, Ce, and combinations thereof. The metal ions reduce the number of acid sites on the zeolite catalyst component. The metal ions can range from 0.1 to 50 wt % based on the total weight of the ion-modified binder. Optionally, the ion-modified binder is present in amounts ranging from 1 to 80 wt % based on the total weight of the catalyst.2011-11-03
20110270008PRETREATMENT OF A PHOSPHORUS-MODIFIED ZEOLITE CATALYST FOR AN AROMATIC ALKYLATION PROCESS - This invention relates to a process for pretreating a zeolite catalyst, specifically a zeolite which has been modified with phosphorus. The catalyst may be used in a process for alkylation of aromatics, specifically toluene methylation. The pretreatment is first to contact the catalyst with the process reactants used in a process for alkylation of aromatics for at least two hours at conditions to produce an alkylated aromatic product and then with a gaseous stream containing oxygen at a temperature and for a time until there is no oxygen consumption. The zeolite may be a MFI zeolite. This pretreatment procedure for a phosphorus-modified zeolite catalyst produces a catalyst which has increased run time, i.e., decreased deactivation rate, compared to a fresh catalyst, even after successive regenerations.2011-11-03
20110270009CATALYTIC CRACKING PROCESS OF A STREAM OF HYDROCARBONS FOR MAXIMIZATION OF LIGHT OLEFINS - A process is described for maximization of light olefins, preferably ethylene, by the catalytic cracking of feeds of saturated hydrocarbons, with molecular size in the range from 4 to 6 carbon atoms. The process uses a catalyst based on a zeolite of type ZSM-5 with low sodium content and modified with nickel, with concentration by weight of nickel, expressed in the form of oxide, in the range from 0.1% to 20% relative to the weight of zeolite in the catalyst, and operating conditions that involve a temperature between 400° C. and 650° C. and feed partial pressure between 0.1 and 1.0 MPa, so that the product recovered is rich in light olefins, with ethylene/propylene ratio in the range from 0.25 to 2.00.2011-11-03
20110270010HYDROGENATION ISOMERIZATION CATALYST, METHOD FOR PRODUCING SAME, METHOD FOR DEWAXING HYDROCARBON OIL, AND METHOD FOR PRODUCING LUBRICANT BASE OIL - A first hydroisomerization catalyst contains a support being a extruded product prepared by calcination having a thermal treatment that includes thermally treating at 350° C. or more and at least one metal supported on the support and selected from the group consisting of metals belonging to Groups 8 to 10 of the periodic table, molybdenum and tungsten, wherein the support contains (a1) a calcined zeolite prepared by calcination having a thermal treatment that includes thermally treating at 350° C. or more of an ion-exchanged zeolite obtained by ion exchange of an organic template-containing zeolite containing an organic template and having a 10-membered ring one-dimensional porous structure in a solution containing ammonium ions and/or protons, and (b1) a calcined inorganic oxide prepared by calcination having a thermal treatment that includes thermally treating at 350° C. or more of one inorganic oxide selected from the group consisting of alumina, silica, titania, boria, zirconia, magnesia, ceria, zinc oxide, phosphorus oxide, and a composite oxide containing a combination of two or more of these oxides, wherein the thermal treatment to which the calcined zeolite has been subjected includes calcination in which the ion-exchanged zeolite that has not been thermally treated at 350° C. or more is heated within the range of 350° C. to 450° C.2011-11-03
20110270011USE OF OPIOIDS OR OPIOID MIMETICS FOR THE TREATMENT OF RESISTANT CANCER PATIENTS - The use of opioids or opioid mimetics is suggested for the manufacture of a medicament for the treatment of resistant cancer patients.2011-11-03
20110270012DEVICE AND METHOD FOR CONTROLLING EMISSION OF RADIATION - Embodiments of the invention include a device for therapeutically delivering radiation to tissue. Some embodiments include a radiation source and a combination of members surrounding the radiation source that move relative to one another to permit or restrict the emitting of radiation from the device. Limits to the movement of the combination of members may be imposed by one or more biodegradable members.2011-11-03
20110270013Pressure-Applying device - A pressure-applying device (PAD) (2011-11-03
20110270014HEARING PROSTHESIS HAVING AN ON-BOARD FITTING SYSTEM - A hearing prosthesis comprising an external component having an integrated user interface, a sound processor configured to process received sounds based on predefined fitting data, and an on-board fitting system configured to set the fitting data in response to control inputs received via the integrated user interface.2011-11-03
20110270015SYSTEMS, DEVICES, AND METHODS FOR MINIMALLY INVASIVE PELVIC SURGERY - The invention, in various embodiments, provides systems, devices, and methods for treating urinary incontinence.2011-11-03
20110270016SELF-ADJUSTING GASTRIC BAND - A self-adjusting gastric band comprises an inflatable portion that includes a fluid such as saline. A reservoir is spaced from the inflatable portion according to a distance related to a wavelength of a peristaltic wave that propagates through the esophageal-gastric junction. A pressure-relief valve is coupled between the inflatable portion and the reservoir and allows an amount of the fluid to pass from the inflatable portion to the reservoir when a first force generates an increased pressure in the inflatable portion. The amount of fluid is released to allow the large bolus to pass through the esophageal-gastric junction. A contracted portion of the peristaltic wave is proximate the reservoir when an expanded portion of the wave is proximate the inflatable portion of the self-adjusting gastric band, to facilitate allowing the amount of the fluid to enter the reservoir.2011-11-03
20110270017SELF-ADJUSTING GASTRIC BAND HAVING VARIOUS COMPLIANT COMPONENTS - A self-adjusting gastric band is automatically adjustable without complicated fluid control mechanisms, flow rate limiting devices, and/or valves. The self-adjusting gastric band may automatically adjust to allow a large bolus of food to pass through a constriction in the patient's stomach formed by the gastric band. The self-adjusting gastric band comprises an inflatable portion that is disposable about an esophageal-gastric junction of the patient. A first compliant portion is coupled to the inflatable portion. The first compliant portion automatically relaxes the constriction formed by the self-adjusting gastric band and allows the large bolus to pass through the constriction. After the bolus passes through the constriction, the self-adjusting gastric band automatically returns to its previous state.2011-11-03
20110270018SELF-ADJUSTING MECHANICAL GASTRIC BAND - A self-adjusting gastric band applies a substantially constant force to a patient's fundus in order to facilitate weight control. The self-adjusting gastric band is capable of automatically relaxing and contracting in response to changes in the patient's fundus or in response to a large bolus passing through the patient's fundus that is constricted by the gastric band. The self-adjusting gastric band is automatically adjustable without hydraulic fluid and without external physician intervention. The self-adjusting gastric band comprises a movable member and a biasing mechanism coupled to the movable member to facilitate applying the substantially constant force against the fundus as the fundus changes size, shape and/or position.2011-11-03
20110270019IMPLANTABLE DEVICE TO PROTECT TUBING FROM PUNCTURE - An implantable device used in a gastric band system includes an access port, a tube coupled to the access port, and a shielding device covering a portion of the tube. The shielding device is positioned adjacent to the access port and covers the end of the tube coupled to the access port. The shielding device is made from a puncture resistant material, to protect the tube from puncture by a misplaced syringe needle inserted by a physician.2011-11-03
20110270020Linear tension internal organ supports and method for using the same - Compact and efficient linear tension internal organ supports and methods of maneuvering the organ supports so as to manipulate (i.e., lift, suspend or displace) an internal organ or soft tissue within the general operating field within the abdominal cavity of a patient undergoing surgery. In certain preferred embodiments, an internal organ support is attached directly to the organ or tissue to be manipulated or to the abdominal wall within the abdominal cavity. In other preferred embodiments, a displacement force is applied to an internal organ support from a location outside the patient's abdomen by way of linear tension lines attached to the organ support and removed from the abdominal cavity through a small exit incision made through the abdominal wall. By virtue of the internal organ supports and methods herein disclosed, only a single, small entry incision need be made so that only a small scar or no visible scar at all will remain on the patient's abdominal skin after the internal organ supports have been removed from the abdominal cavity following the surgery.2011-11-03
20110270021ELECTRONICALLY ENHANCED ACCESS PORT FOR A FLUID FILLED IMPLANT - The present invention provides for an access port configured to detect its tilt within the body to facilitate a physician's access thereto. The access port can include a tilt detector to detect tilt datum, and a display screen to display the tilt of the access port. In addition, the tilt detector and the display screen can indicate whether the access port is flipped or not. The tilt detector can include an accelerometer to aid in determining the tilt of the access port.2011-11-03
20110270022BIOCOMPATIBLE AND BIOSTABLE IMPLANTABLE MEDICAL DEVICE - The present invention is related to a biocompatible and biostable implantable medical device. The present invention can include an implantable medical device including an electro-mechanical component. The electro-mechanical component can be coated with various novel and nonobvious coating combinations designed to promote biocompatibility and biostability. One layer of the coating combinations can be a tie layer. Another layer of the coating combinations can be a layer formed on top of the tie layer, and having biocompatible and biostable properties.2011-11-03
20110270023IMPLANTABLE DEVICE TO PROTECT TUBING FROM PUNCTURE - An implantable device used in a gastric band system includes an access port, a tube coupled to the access port, and a shielding device covering a portion of the tube. The shielding device is positioned adjacent to the access port and covers the end of the tube coupled to the access port. The shielding device is made from a puncture resistant material, to protect the tube from puncture by a misplaced syringe needle inserted by a physician.2011-11-03
20110270024SELF-ADJUSTING GASTRIC BAND HAVING VARIOUS COMPLIANT COMPONENTS - In some embodiments, the present invention generally provides self-adjusting gastric banding systems for the treatment of obesity and obesity related conditions, as well as systems for allowing the automatic self-adjustment of gastric bands when a patient swallows a large bolus. In some embodiments, the present invention generally provides for gastric banding systems having a satiety booster, for example, to increase satiety levels when a patient desires to curb appetite at a particular time. In some embodiments, the present invention may provide for gastric banding systems that allow for both the automatic self-adjustment of gastric bands when a patient swallows a large bolus and an incorporated satiety booster for increasing satiety levels when a patient desires to curb appetite at a particular time.2011-11-03
20110270025REMOTELY POWERED REMOTELY ADJUSTABLE GASTRIC BAND SYSTEM - A remotely adjustable remotely power gastric band system may include a control device, an implant electronic device, and an implantable gastric band. The control device may telemetrically power and communicate with the implant electronic device, which may be used for adjusting the diameter of the implantable gastric band. The implant electronic device may store the gastric band adjustment history records of a patient and regulate the power received from the control device. To improve transmission efficiency, the implant electronic device may adopt a double modulation scheme for communicating with the control device. Furthermore, the implant electronic device may detect and resolve motor blockage issues related to the implantable gastric band.2011-11-03
20110270026DELIVERING PELVIC FLOOR REPAIR IMPLANTS - A medical device for the delivery of pelvic floor repair implants within a pelvic region of a body includes a handle, an elongated shaft member, and a head. A method of delivering a pelvic floor repair implant in a transvaginal implant procedure includes inserting and deploying at least a portion of the medical device into a pelvic region of a body.2011-11-03
20110270027METHOD AND SYSTEM FOR DETERMINING THE PRESSURE OF A FLUID IN A SYRINGE, AN ACCESS PORT, A CATHETER, AND A GASTRIC BAND - A method and system for determining pressure in a syringe, and more specifically to a syringe pressure accessory which can be connected to a syringe to determine pressure in a syringe and a gastric band. The syringe pressure accessory can detect a pressure of a syringe and/or a gastric band and digitally display the pressure. The syringe pressure accessory can include a durable unit and a disposable unit. The disposable unit can be disposed of after a single use, while the durable unit can be reused with multiple disposable units. The syringe pressure accessory can also include a syringe attachment unit and one or more display units for a caretaker or a patient. The display unit can be wirelessly connected to the syringe attachment unit to display a pressure chart or the results of various analysis of the pressure data. Markers can be added to the pressure chart.2011-11-03
20110270028BIOCOMPATIBLE AND BIOSTABLE IMPLANTABLE MEDICAL DEVICE - The present invention is related to a biocompatible and biostable implantable medical device. The present invention can include an implantable medical device including an electro-mechanical component. The electro-mechanical component can be coated with various novel and nonobvious coating combinations designed to promote biocompatibility and biostability.2011-11-03
20110270029GASTRIC BAND WITH ELECTRICAL STIMULATION - A gastric band system including a functional electrical stimulation component is provided. Stimulation electrodes on the gastric band may be used to stimulate the vagal nerve and/or splanchnic nerve, which can inhibit the patient's appetite. The gastric band may have an inflatable member for adjusting a stoma size. The stimulation electrodes may be mounted on the inflatable member. The system may include a controller including a pressure sensor for monitoring the hydraulic pressure within the inflatable inner member and for controlling the stimulation component.2011-11-03
20110270030HYDRAULIC GASTRIC BAND WITH COLLAPSIBLE RESERVOIR - A self-regulating gastric band apparatus for adjusting stoma size. The apparatus includes an adjustable gastric band with an expandable inner ring. A band adjustment assembly includes a sensor for sensing fluid pressure in the inner ring and a pump assembly connected to the inner ring and to a controller for adjusting the volume of the fluid in the band based on the sensed fluid pressure. A memory stores an operating range of a target fluid pressure, and the pump assembly maintains the sensed band pressure within the operating range. An elongated fluid reservoir extends along part of a fill tube. An expandable fluid reservoir stores a volume of the fluid for adjusting the volume of fluid in the lumen. A protective outer sheath is provided around the exterior of an expandable fluid reservoir in both a first, deflated state, and a second, inflated state of the reservoir.2011-11-03
20110270031SYSTEM AND METHOD FOR AIRWAY MANIPULATION - Methods and devices are disclosed for manipulating the airway, such as to treat obstructive sleep apnea. An implant is positioned within the body with respect to the airway. The spatial orientation of the airway is manipulated, directly or indirectly, to affect the configuration of the airway. In general, the implant is manipulated to displace the trachea in an inferior direction, resist superior displacement of the trachea and/or to alter the tracheal wall tension. The implant restrains the trachea in the manipulated configuration.2011-11-03
20110270032TRACTAL ERECTILE DEVICE - A tractal erectile device is disclosed. In one embodiment, the device includes a hollow vessel having a first opening for receiving an organ, and a second opening for releasing fluid from within the vessel. The hollow vessel may include: an integral smooth lip portion surrounding the first opening for receiving an organ; an elongated cylindrical portion connected to the lip portion, an hour-glass portion connected to the elongated portion, and an ellipsoid shaped end portion including the second opening for releasing fluid from within the vessel.2011-11-03
20110270033INTERCHANGEABLE ATTACHMENT CONNECTOR SYSTEMS - The present invention relates to an interchangeable attachment connector system, characterized in that said system comprises: (a) a connector member, wherein said connector member comprises a shaft, said shaft having an engagement end and a distal end, wherein at least a portion of the shaft includes male threads; and (b) an interchangeable attachment capable of being removably engaged to the shaft of the connector member, the interchangeable attachment comprising a body, wherein said body includes two axial ends, an entry opening located in one of said axial ends and an axial bore extending from the entry opening, wherein said bore includes an entry opening and internal walls having female threads complementary to the male threads on the shaft of the connector member, wherein the shaft and the interchangeable attachment can be pushed together for engagement by inserting the engagement end of the shaft through the entry opening, and wherein engagement between the male threads and the female threads on the shaft and the interchangeable attachment prevent relative longitudinal pull-out motion between the engaged shaft of the connector member and interchangeable attachment while allowing relative rotational motion for disengagement of the interchangeable attachment from the shaft of the connector member. In aspects of the invention the interchangeable attachment comprises an interchangeable sexual aid device.2011-11-03