43rd week of 2011 patent applcation highlights part 50 |
Patent application number | Title | Published |
20110263663 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF - The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. | 2011-10-27 |
20110263664 | Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer - The disclosure relates to inhibitors of Pim-1 and/or Pim-2 protein kinase, to compositions comprising one or more inhibitors of Pim-1 and/or Pim-2 protein kinase, and to methods for treating cancer. | 2011-10-27 |
20110263665 | FORMULATIONS COMPRISING AN ANTI-MICROBIAL COMPOSITION - The present invention describes a formulation comprising: (A) at least one surfactant; and (B) an anti-microbial composition that comprises (i) an anti-microbial agent with surfactant properties; (ii) a hydrophobic material and (iii) a polar solvent. | 2011-10-27 |
20110263666 | PROCESS FOR THE PREPARATION OR PURIFICATION OF OLMESARTAN MEDOXOMIL - The present invention relates to a process for the preparation and purification of olmesartan medoxomil hydrohalide salts and optionally converting them to olmesartan medoxomil. The invention also relates to products obtainable by the process of the invention, to pharmaceutical compositions comprising the products and to their use in medicine, particularly to treat hypertension. | 2011-10-27 |
20110263667 | SALTS OF ISOBUTYRIC ACID (1 R*,2R*,4R*) -2- (2- - ETHYL)-5-PHENYL-BICYCLO [2.2.2] OCT-5-EN-2-YL - The invention relates to crystalline salts of isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester, processes for the preparation thereof, pharmaceutical compositions containing said crystalline salts, and their use as medicaments, especially as calcium channel blockers. | 2011-10-27 |
20110263668 | Beta 3-Adrenoreceptor Agonists for the Treatment of Cardiac Hypertrophy and Heart Failure - The present invention relates to the field of cardiology. More specifically, the present invention relates to the use of β3 adrenoreceptor agonists to treat cardiac hypertrophy and heart failure. In a specific embodiment, a method for treating cardiac hypertrophy comprises the step of administering a therapeutically effective amount of a β3 adrenoreceptor agonist to a patient diagnosed with cardiac hypertrophy. In a more specific embodiment, the method for treating cardiac hypertrophy comprises the step of administering a therapeutically effective amount of the β3 adrenoreceptor agonist BRL 26830A to a patient diagnosed with cardiac hypertrophy. In a further embodiment, the present invention provides a method for treating a cardiovascular disease or condition associated with cardiac hypertrophy comprising the step of administering a therapeutically effective amount of a β3 adrenoreceptor agonist to a patient diagnosed with cardiac hypertrophy. | 2011-10-27 |
20110263669 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors - The invention relates to pyrrolo[2,3-a]carbazole derivatives, to a method for preparing the same, and to the use thereof as PIM kinase inhibitors. The invention can particularly be used in the pharmaceutical field. | 2011-10-27 |
20110263670 | NOVEL POLYMORPHS OF SUNITINIB AND PROCESSES FOR THEIR PREPARATION - The present invention relates to novel polymorphs of sunitinib free base designated form II and form III and to processes for their preparation. The invention also relates to their use as APIs and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising said novel polymorphs and salts, solvates and hydrates prepared according to the invention, and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer. | 2011-10-27 |
20110263671 | NOVEL SALTS OF SUNITINIB - Pharmaceutically acceptable salts of sunitinib, processes of making sunitinib salts, as well as related pharmaceuticals and methods of treating are described. | 2011-10-27 |
20110263672 | Metabolites of Wortmannin Analogs and Methods of Using the Same - Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein. | 2011-10-27 |
20110263673 | Atropisomers of (Hydroxyalkyl) Pyrrole Derivatives - The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I): wherein R | 2011-10-27 |
20110263674 | C-NITROSO-DERIVED NITROXYL DONORS - Active compounds of Formula I are described: | 2011-10-27 |
20110263675 | METHODS OF MODULATING MESENCHYMAL STEM CELL DIFFERENTIATION - The present disclosure includes compositions and methods for modulating the differentiation of cells having osteogenic differentiation potential (such as mesenchymal stem cells (MSCs)) towards the osteogenic fate, and for obtaining diagnostic and prognostic information relating to diseases and disorders characterized by defects in osteogenic differentiation. The compositions include miRNAs, rm′RNA mimics, miRNA inhibitors, and siRNAs. | 2011-10-27 |
20110263676 | SMALL INTERFERING RNA FOR GENE KNOCKDOWN OF THE SUBCUTANEOUS N-METHYL-D-ASPARTATE RECEPTOR NR1 SUBUNIT, AND IT'S APPLICATION ON PHARMACEUTICS - A small interfering RNA for gene knockdown of the N-methyl-D-aspartate receptor NR1 subunit comprises 21 to 25 ribonucleic acids, which are homologous to the RNA sequence of N-methyl-D-aspartate receptor NR1 subunit. A method of using the small interfering RNA, applying the small interfering RNA on subcutaneous tissues temporary interfere with the genetic expression of the NMDA receptor NR1 subunit in hypoderm. A use of the small interfering RNA on pharmaceutics, applying the small interfering RNA manufacture into new analgesic drugs for moderating the inflammatory pain or intolerable chronic pain, especially on clinical chronic pain and burn pain patients. An analgesic drug for skin inflammatory pain comprising: the small interfering RNA and a siRNA acceptable vehicle. | 2011-10-27 |
20110263677 | GOS2 MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA - An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of G0/G1 switch protein 2 (GOS2), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured. | 2011-10-27 |
20110263678 | INHIBITORS OF TGF-R SIGNALING FOR TREATMENT OF CNS DISORDERS - The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia,—Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration. | 2011-10-27 |
20110263679 | C12ORF48 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS - Objective methods for diagnosing a predisposition to developing pancreatic cancer and prostate cancer, particularly pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, are described herein. In one embodiment, the diagnostic method involves the step of determining an expression level of C12ORF48 using siRNAs targeting the C12ORF48 gene. The invention also features products such as siRNAs as well as to compositions containing them. The present invention further provides methods of screening for therapeutic agents useful in the treatment of C12ORF48 associated disease, such as a cancer, e.g. pancreatic cancer and prostate cancer, as well as methods of inhibiting the cell growth and treating or alleviating one or more disease symptoms. The invention also features products such as double stranded molecules, as well as vectors and compositions containing them. | 2011-10-27 |
20110263680 | REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS - The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing. The RNAi constructs may be, for instance, miRNA constructs that are miRNA modulators. | 2011-10-27 |
20110263681 | Organic Compositions to Treat Beta-ENaC-Related Diseases - The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC. | 2011-10-27 |
20110263682 | METHODS AND MEANS FOR EFFICIENT SKIPPING OF AT LEAST ONE OF THE FOLLOWING EXONS OF THE HUMAN DUCHENNE MUSCULAR DYSTROPHY GENE: 43, 46, 50-53 - The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD pre-mRNA in a patient, preferably in an isolated cell of a patient, the method comprising providing said cell and/or said patient with a molecule. The invention also relates to said molecule as such. | 2011-10-27 |
20110263683 | RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA) - The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism. | 2011-10-27 |
20110263684 | Lipid Formulated Compositions and Methods for Inhibiting Expression of Serum Amyloid A Gene - The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA. | 2011-10-27 |
20110263685 | Method for Identification of Sensitivity of a Patient to Telomerase Inhibition Therapy - The invention provides methods for determining the susceptibility of cancer patients to developing adverse reactions if treated with a telomerase inhibitor drug by measurement of telomere length in appropriate cells of the patient prior to initiation of the telomerase inhibitor treatment. | 2011-10-27 |
20110263686 | ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF - An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202. | 2011-10-27 |
20110263687 | RNA MOLECULES AND USES THEREOF - The present invention relates to substantially single-stranded isolated RNA molecules comprising 18 to 19 contiguous nucleotides that corresponds to a non-protein-coding genomic DNA sequence located between −60 and +120 nucleotides from a transcription start site in a mammalian genome. Specifically, the isolated RNA molecules have a high GC content (>60%), are nuclear specific, and may be associated with aberrant gene regulation and/or transcription in various mammalian diseases and conditions. The isolated RNA molecules, modified RNA molecules and fragments thereof may be particularly useful for the diagnosis, prognosis and treatment of diseases such as Crohn's disease, Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, myocardial infarction, diabetes, congenital developmental disorders, coronary heart disease and cancer such as breast cancer, lymphoma, leukemia, aggressive metastatic brain cancers, colorectal cancer, gastric cancer, ovarian cancer and pituitary tumors. | 2011-10-27 |
20110263688 | COFERONS AND METHODS OF MAKING AND USING THEM - A monomer useful in prepaπng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof | 2011-10-27 |
20110263689 | AKT Ligands and Polynucleotides Encoding AKT Ligands - The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate AKT activity. The ligands, homopolyligands, and heteropolyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands, homopolyligands, and heteropolyligands. | 2011-10-27 |
20110263690 | Methods and Compositions for use in Gene Therapy for Treatment of Hemophilia - Provided are compositions of viruses, the viruses including a recombinant adeno-associated virus vector comprising at least two adeno-associated virus inverted terminal repeats, a promoter/regulatory sequence, isolated DNA encoding a blood coagulation factor and accompanying 5′ and 3′ untranslated regions and a transcription termination sequence. | 2011-10-27 |
20110263691 | METHODS CONCERNING PPAR DELTA AND ANTAGONISTS THEREOF - Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their suitability for the treatment of inflammatory skin conditions such as psoriasis. Methyl 3-({[2-(methoxy)-4-phenyl]amino}sulfonyl)-2-thiophenecarboxylate can be administered topically for the prevention or treatment of psoriasis. | 2011-10-27 |
20110263692 | THERAPEUTIC COMPOUNDS - A compound having a structure | 2011-10-27 |
20110263693 | CELASTROL, GEDUNIN, AND DERIVATIVES THEREOF AS HSP90 INHIBITORS - Based on the discovery that celastrol and gedunin are Hsp90 inhibitors, the present invention provides novel inhibitors of Hsp90. and pharmaceutically acceptable salts, derivatives, and compositions thereof. The invention provides two classes of compounds. One class includes celastrol and its derivatives. The other class includes gedunin and its derivatives. The present invention further provides methods for treating disorders wherein Hsρ90 inhibition is desired (e.g., proliferative diseases, cancer, inflammatory diseases, fungal infections, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. Celastrol, gedunin, and derivatives thereof are particularly useful in the treatment of prostate cancer, breast cancer, ovarian cancer, lung cancer, and leukemia. | 2011-10-27 |
20110263694 | Use of Xanthone Derivatives as a Medicament for Cancer - The invention relates to xanthone derivatives of formula (IA) or (IB) and their use for manufacturing a medicament for cancer, and in particular for chemotherapeutic resistant cancer. More particularly, the invention relates to compounds and compositions comprising such xanthone derivatives for the prevention and/or treatment for chronic leukemia and, for example, for chronic lymphocytic leukemia (CLL) or B-lymphoma. | 2011-10-27 |
20110263695 | NFAT Signal Inhibitor and Hair-Growing Agent - An NFAT signal inhibitor and the like are provided. | 2011-10-27 |
20110263696 | PROANTHOCYANIDINS FROM CINNAMON AND ITS WATER SOLUBLE EXTRACT INHIBIT TAU AGGREGATION - Compositions comprising proanthocyanidin compositions (e.g. those extracted from | 2011-10-27 |
20110263697 | Methods of Reducing Oxidative Modification of a Muscle Cell Protein - The present invention is directed to methods for reducing oxidative modification of one or more proteins or other cellular constituents involved in muscle cell contraction, for reducing muscle fatigue or for increasing muscle performance. | 2011-10-27 |
20110263698 | PROANTHOCYANIDIN OF CASHEW APPLE, COMPOSITION CONTAINING PROANTHOCYANIDIN, AND APPLICATION THEREOF - This invention provides useful applications of cashew apple. This invention also provides a naturally occurring active ingredient having useful activities, such as alpha-amylase inhibitory activity, lipase inhibitory activity, and antibacterial activity against | 2011-10-27 |
20110263699 | 1-Phenyl-2-DimethylaminomethylCyclohexane Compounds and Therapies for Depressive Symptoms, Pain and Incontinence - Metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression, pain and urinary incontinence. | 2011-10-27 |
20110263700 | ANTROCIN CONTAINING PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CANCER CELLS - This subject invention is directed to a pharmaceutical composition for the inhibition of cancer cells, comprising an effective amount of a compound of formula I (Sesquiterpene lactones, antrocin) or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier. | 2011-10-27 |
20110263701 | GABAPENTIN ENACARBIL COMPOSITIONS - The present invention provides a stabilized composition comprising a non-crystalline gabapentin enacarbil and at least one crystallization-inhibiting compound. In particular, the present invention provides a stabilized composition of gabapentin enacarbil, wherein the gabapentin enacarbil is maintained in a non-crystalline form by the composition, for example, as an amorphous form. The invention also provides, among other things, methods of making the stabilized composition, or use of the stabilized composition for making a medicament. | 2011-10-27 |
20110263702 | Methods and Compositions for Improved Chromium Complexes - Complex metal-containing matrices, and especially chromium-containing matrices are produced from a water soluble preparation that is derived from an item suitable for animal (and most typically human) consumption. In particularly contemplated aspects, the water soluble preparation is an extract or filtrate of disintegrated brewer's yeast, and the so prepared complex mixture is combined with a chromium-3 | 2011-10-27 |
20110263703 | SOLID FORMS OF SELECTIVE ANDROGEN RECEPTOR MODULATORS - The present invention relates to solid forms of (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide and process for producing the same. | 2011-10-27 |
20110263704 | Methods of Using Cycloalkylmethylamines - The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications. | 2011-10-27 |
20110263705 | TRANSDERMAL DELIVERY OF KETOPROFEN POLAR DERIVATES - A topical or transdermal composition including a polar derivative of ketoprofen and a pharmaceutically acceptable topical or transdermal carrier, wherein the polar derivative of ketoprofen comprises a polarity that is greater than that of ketoprofen. | 2011-10-27 |
20110263706 | METHOD FOR ENHANCING THE DNA REPAIR PROCESS, TREATING DISORDERS ASSOCIATED WITH THE DNA REPAIR PROCESS, ENHANCING ANTITUMOR RESPONSE AND TREATING DISORDERS ASSOCIATED WITH ANTI-TUMOR RESPONSE IN MAMMALS BY ADMINISTERING PRUIFIED QUINIC ACID AND/OR CARBOXY ALKYL ESTER - The disclosure provides a method for isolating the bioactive component of the water-soluble extract of | 2011-10-27 |
20110263707 | MOSQUITO REPELLENT - The present invention relates to a mosquito repellent comprises at least one or more selected from the group consisting of neric acid and derivatives thereof in an effective amount to repel mosquito. | 2011-10-27 |
20110263708 | Over-production of dihomo linolenic acid by a mutant strain of parietochloris incisa - The present invention is primarily directed to a mutant strain of | 2011-10-27 |
20110263709 | METHOD FOR OBTAINING POLYUNSATURATED FATTY ACID-CONTAINING COMPOSITIONS FROM MICROBIAL BIOMASS - A method is disclosed for obtaining a refined lipid composition comprising at least one polyunsaturated fatty acid from a microbial biomass, wherein the refined lipid composition comprises at least one polyunsaturated fatty acid and is enriched in triacylglycerols relative to the oil composition of the microbial biomass. | 2011-10-27 |
20110263710 | Transepithelial methods of using gamma aminobutyric acid compositions for pain relief - Disclosed are methods for alleviating, relieving, inhibiting, and eliminating acute or chronic pain in a patient suffering from such pain by contacting epithelial tissue of the patient with exogenous GABA (gamma-amino butyric acid). | 2011-10-27 |
20110263711 | 1-(2-FLUOROBIPHENYL-4-YL)-ALKYL CARBOXYLIC ACID DERIVATIVES FOR THE THERAPY OF TRANSTHYRETIN AMYLOIDOSIS - Derivatives of 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid are capable of stabilizing the tetrameric native state of transthyretin for the prophylaxis and treatment of amyloidosis. | 2011-10-27 |
20110263712 | PROCESS FOR THE PREPARATION OF VORINOSTAT - The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient vorinostat. In particular it relates to a process for preparing vorinostat substantially free from impurities, involving suberic acid, aniline and hydroxylamine as starting materials. | 2011-10-27 |
20110263713 | POLYMORPHS - The present invention relates to crystalline forms of the active pharmaceutical ingredient vorinostat, processes for their preparation and their use in pharmaceutical compositions. Formula (I). | 2011-10-27 |
20110263714 | Reverse Vesicle - The reverse vesicle composition of the present invention includes (A) a sphingosine represented by formula (1) (wherein R | 2011-10-27 |
20110263715 | Local Anesthetic Emulsion Compositions and Methods of Making and Using the Same - Local anesthetic emulsion compositions are provided. The local anesthetic emulsion compositions may include: an oily phase comprising a eutectic mixture of a local anesthetic and an acyclic amide; a surfactant; and an aqueous phase. Also provided are methods of making and using the emulsions. | 2011-10-27 |
20110263716 | COLCHINE COMPOSITIONS AND METHODS - Stable ultrapure colchicine compositions comprising ultrapure colchicine and a pharmaceutically acceptable excipient are described. The compositions can be tablets. Methods for preparing such compositions and methods of use are also disclosed. Methods of treating gout flares with colchicine compositions are also disclosed. | 2011-10-27 |
20110263717 | Ophthalmic Compositions with Biguanide and PEG-Glycerol Esters - Ophthalmic compositions that comprise 0.1 ppm to 2 ppm of poly(hexamethylene biguanide); and 0.005 wt. % to 0.3 wt. % of a PEG-glycerol ester of general formula I | 2011-10-27 |
20110263718 | PROCESS FOR THE PREPARATION OF O-DESMETHYLVENLAFAXINE - The present invention provides a convenient and efficient process for the preparation of O-desmethylvenlafaxine (ODV) or a salt thereof, comprising the reaction of venlafaxine, or a salt thereof, with a thiourea or a mixture of thioureas. | 2011-10-27 |
20110263719 | POLYMORPHIC FORM OF RASAGILINE MESYLATE - The present invention relates to a novel crystalline form of rasagiline mesylate and a pure form of rasagiline mesylate and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said forms and use of said compositions in the treatment of patients suffering from Parkinson's Disease, dementia, Alzheimer's Disease, depression, hyperactive syndrome, stroke, brain ischemia, neurotrauma, schizophrenia and multiple sclerosis. | 2011-10-27 |
20110263720 | SYNTHESIS OF ALPHA-TOCOPHEROLQUINONE DERIVATIVES, AND METHODS OF USING THE SAME - The present invention is directed to a method of synthesizing a compound of Formula I: | 2011-10-27 |
20110263721 | ARYL DI-SUBSTITUTED PROPENONE COMPOUNDS - Compounds of formula (I): | 2011-10-27 |
20110263722 | Well Defined stars with segmented arms - The present invention relates to the preparation and use of well defined star macromolecules wherein the composition of the arms are selected to induce self assembly when the multi-arm segmented star macromolecules are dispersed in a liquid. The self assembled star macromolecules modify the rheology of the dispersing media. When targeting use in aqueous based systems the inner shell of the star macromolecules comprise non-ionizable monomer units. Compositions comprising the self assemblable star macromolecules are suitable for use as rheology modifiers in a number of applications including cosmetic and personal care compositions. | 2011-10-27 |
20110263723 | Pigment Composition Comprising Anthocyanic Vacuolar Inclusions - The invention provides a pigment composition comprising anthocyanic vacuolar inclusions or “AVIs” from a plant, and an acceptable carrier. The invention also provides methods for colouring products with the pigment composition, and products comprising the pigment composition or AVIs. | 2011-10-27 |
20110263724 | THREADS OF HYALURONIC ACID AND/OR DERIVATIVES, THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF - The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc. | 2011-10-27 |
20110263725 | Alpha-branched Alkenoic Acids and the Use of Alpha-branched Alkanoic and Alkenoic Acids as a Fragrance - The present invention refers to alpha branched alkanoic and alkenoic acids of formula (I) | 2011-10-27 |
20110263726 | PROCESS FOR SELECTIVE OXIDATIVE DEHYDROGENATION OF A HYDROGEN-CONTAINING CO MIXED GAS - A process for selective oxidative dehydrogenation of a hydrogen-containing CO mixed gas, comprising contacting a hydrogen-containing CO mixed gas raw material with at least one catalyst entity having an increased activity gradient disposed in a reactor under at least one reaction condition chosen from a reaction temperature ranging from 100 to 300° C., a volume space velocity ranging from 100 to 10000 h | 2011-10-27 |
20110263727 | POLYMERIC MEDIUM - A PBI compound includes imidazole nitrogens at least a portion of which are substituted with a moiety containing a carbonyl group, the substituted imidazole nitrogens being bonded to carbon of the carbonyl group. At least 85% of the nitrogens may be substituted. The carbonyl-containing moiety may include RCO—, where R is alkoxy or haloalkyl. The PBI compound may exhibit a first temperature marking an onset of weight loss corresponding to reversion of the substituted PBI that is less than a second temperature marking an onset of decomposition of an otherwise identical PBI compound without the substituted moiety. The PBI compound may be included in separatory media. A substituted PBI synthesis method may include providing a parent PBI in a less than 5 wt % solvent solution. Substituting may use more than 5 equivalents in relation to the imidazole nitrogens to be substituted. | 2011-10-27 |
20110263728 | RECYCLED LATEX FOAM MATERIAL AND ITS PREPARATION METHOD - A recycled latex foam material is prepared by mixing polyurethane with recycled waste latex grains to cause a polymerization reaction and then feeding the polymerized recycled waste latex foam grains and polyurethane mixture into a mold for molding into a finished product. The method of the invention is environmentally friendly and practical for making latex foam pads of different hardnesses and densities for different application purposes by using different grain sizes of recycled waste latex grains with polyurethane. The finished product has comfort wearing, breathing, anti-slip, anti-bacterial and cost-saving characteristics. | 2011-10-27 |
20110263729 | Fiber or Foil from Polymers with High Tg and Process for their Manufacture - A process for the manufacture of a fiber or foil comprising at least one optionally functionalized polymer with a high Tg selected from the group consisting of poly(aryl ether sulfone) (PAES), poly(aryl ether ketone) (PAEK) and aromatic polyimide, comprising the steps of (aa) providing a solution comprising at least 45 wt. % of the polymer, and at least 20 wt. % of at least one halogen-free organic solvent (S1) for the polymer, both wt % based upon the weight of the solution; (bb) pushing the solution through a nozzle; and (cc) introducing the solution into a coagulation bath comprising: (cc1) at least one liquid (L1) in which the polymer is insoluble, and optionally (cc2) at least one organic solvent (S2) for the polymer, identical to or different from the organic solvent (S1), to form a fiber or foil. A fiber or foil obtained by this process as well as to fibers or foils with specific porosity features and/or mechanical properties. | 2011-10-27 |
20110263730 | METHOD AND APPARATUS FOR PRODUCING POLYMER PARTICLES - Provided are: a manufacturing method for polymer particles, including: mixing a polymer solution, which is obtained by dissolving a polymer in a good solvent, and a polymer non-solvent, which is a non-solvent for the polymer and has compatibility with the good solvent, in a continuous or intermittent manner; and allowing a mixed solution of the polymer solution and the polymer non-solvent to flow down through a tubular body provided substantially vertically, thereby completing the precipitation of polymer particles; and a manufacturing apparatus for polymer particles. The manufacturing method enables the manufacture of polymer particles which have a relatively narrow particle diameter distribution even when the polymer particles are kept in a dispersion solution state. | 2011-10-27 |
20110263731 | EXPANDABLE PHENOLIC RESIN COMPOSITION, PHENOLIC RESIN FOAM, AND METHOD FOR PRODUCING THE PHENOLIC RESIN FOAM - There is provided an expandable phenolic resin composition comprising: a phenolic resin; an acid curing catalyst for the resin; a foaming agent; and a surfactant, wherein the foaming agent comprises a hydrocarbon-based foaming agent; and the surfactant is a polyoxyethylene alkyl ether having an alkyl ether moiety having 14 to 22 carbon atoms, and the content of the surfactant is 0.01 to 10 parts by weight relative to 100 parts by weight of the phenolic resin. | 2011-10-27 |
20110263732 | Polylactic Acid Foam Composition - A foam precursor mixture of polylactic acid (PLA) resin having a D-lactic acid content that is about 3 mole % or less; nucleating agent; chain extender; and hydrocarbon blowing agent is provided. The foaming mixture is substantially free of a crosslinking agent. The foam premixture can be used to prepare PLA foams having improved heat resistance, lower densities, smaller cells, and higher cell counts. PLA foams in accordance with the invention may be useful for preparing thermoformed articles such as trays. PLA foamed articles may be prepared that exhibit heat resistance above a temperature of about 49° C. or more, and in particular, a heat resistance at 5 minutes of exposure in excess of about 74° C. | 2011-10-27 |
20110263733 | METHOD OF MODIFYING GLOSS WITH SILICA ADDITIVES AND RELATED PRODUCTS AND USES - The present invention relates to methods of modulating the gloss of moulded plastics products, such as articles in the automotive industry e.g. for the interior of automobiles, as well as the use of certain additives for that purpose and related invention embodiments. The modulating comprises adding at least one silica additive to a polymer composition used as polymer substrate for the moulded articles. | 2011-10-27 |
20110263734 | Blowing agents formed from nanoparticles of carbonates - The present invention relates to the preparation and use of a blowing agent in the form of of nanoparticles of an inorganic carbonate, and an acid. The acid is capable of being liquefied by heating to be reactive with the carbonate to release carbon dioxide that is useful as a blowing agent in all types of organic foams. The blowing agent, optionally pelletized in a suitable polymer carrier, is useful as a heat-activated blowing agent additive in polymer compositions. | 2011-10-27 |
20110263735 | LIGHTWEIGHT MICROCELLULAR POLYAMIDE SHAPED ARTICLES - Optionally reinforced, lightweight microcellular polyamide shaped articles, e.g., automotive body or interior parts, are produced by injection molding a polyamide matrix in the presence of a fluid in the supercritical state. | 2011-10-27 |
20110263736 | PROCESS FOR PRODUCING RIGID POLYURETHANE FOAMS - The invention relates to a process for producing rigid polyurethane foams by reacting
| 2011-10-27 |
20110263737 | PROCESS FOR PRODUCING RIGID POLYURETHANE FOAMS - The invention relates to a process for producing polyurethanes by reacting
| 2011-10-27 |
20110263738 | EXPANSION MOLDED BODY AND METHOD FOR PRODUCING EXPANSION MOLDED BODY - A foamed article comprising a polyolefin resin composition (I) comprising a polyvinyl alcohol fiber (A), a polyolefin resin (B), and an unsaturated carboxylic acid-modified polyolefin resin and/or an unsaturated carboxylic acid derivative-modified polyolefin resin (C);
| 2011-10-27 |
20110263739 | HARDENABLE TWO PART ACRYLIC COMPOSITION - A hardenable two part acrylic composition, a polymer component of the two part hardenable composition and a method of producing a polymer component of the two part composition are disclosed. The hardenable two part acrylic composition includes an acrylic polymer composition first part and an acrylic monomer composition second part. The acrylic polymer composition first part includes a first type of acrylic polymer particles wherein each first type of acrylic polymer particle is formed of a network of coalesced emulsion polymerized acrylic microparticles or is microporous. The acrylic polymer composition may include emulsion polymerised acrylic polymer particles of particle size between 10 and 2000 nm and includes the use of acrylic polymer particles formed of a network of coalesced emulsion polymerized acrylic microparticles as a dough time reduction agent in a hardenable two part acrylic composition. | 2011-10-27 |
20110263740 | EXPANDABLE POLYURETHANE COMPOSITION AND MANUFACTURING METHOD OF POLYURETHANE FOAM - An expandable polyurethane composition contains (A) a polyisocyanate, (B) an active hydrogen containing compound containing (B1) a polyol and (B2) water, and (C) a cross-linking agent composition. The cross-linking agent composition (C) contains a cross-linking agent (C1) and a carboxylic acid (C2). The cross-linking agent (C1) can be selected from an alkanolamine (a) represented by an expression: H | 2011-10-27 |
20110263741 | SOFT POLYURETHANE FOAM WITH LOW RESILIENCE AND THE PREPARATION METHOD THEREOF - A novel flexible, low resilience polyurethane foam based on a reaction product of isocyanate-reactive component with isocyanate component is disclosed. The flexible, low resilience polyurethane foam is prepared by reacting (a) an isocyanate component substantially free of aromatic isocyanates having isocyanate group attached directly to aromatic ring, (b) an isocyanate-reactive mixture, (c) catalyst, and (d) optionally, one or more substance selected from the group consisting of water, surfactant, cross-linker, and additive. The flexible, low resilience polyurethane foam produced according to the present method has an isocyanate index of from 75 to 105, a density ranging from 16 to 160 kilogram per cubic meter, and ball resilience of less than 15%. | 2011-10-27 |
20110263742 | PROCESS FOR PREPARING POLYETHER ALCOHOLS - The invention relates to a process for preparing polyether alcohols by reacting a) aromatic amines with b) alkylene oxides in the presence of c) a catalyst, wherein the alkylene oxide b) comprises at least 90% by weight, based on the weight of the component b), of propylene oxide and an amine is used as catalyst c). | 2011-10-27 |
20110263743 | NOVEL CATALYSTS FOR REACTION BETWEEN AN ISOCYANATE AND AN ALCOHOL - Catalysts, which are not tin-based, are described for use in a reaction between an isocyanate and an alcohol, which is a key step for preparing polyurethane polymers. | 2011-10-27 |
20110263744 | Novel weather-resistant polyurethane casting compounds, a process for preparation thereof and use thereof - The invention concerns novel weather-resistant polyurethane casting compounds, a process for preparation thereof and use thereof in the building sector. | 2011-10-27 |
20110263745 | Flame Retardant Combinations For Polyesters And Flame Retarded Polyester Moulding Compositions Therefrom - Disclosed are new compositions consisting of mixtures of flame retardants for thermoplastic polyesters based on a phosphinate salt, phosphonate oligomers, polymers or copolymers and a melamine derivative. The compositions exhibit an excellent combination of processing characteristics, thermal and mechanical properties, and are flame retardant. Further disclosed are articles of manufacture produced from these materials, such as fibers, films, coated substrates, moldings, foams, fiber-reinforced articles, or any combination thereof. | 2011-10-27 |
20110263746 | THERMALLY EXPANDABLE MICROCAPSULE AND FOAM-MOLDED ARTICLE - The present invention has its object to provide a thermally expandable microcapsule, which shows excellent heat resistance and a high expansion ratio and thereby can be suitably used for molding processes involving high shearing force, such as kneading molding, calender molding, extrusion molding, and injection molding. The present invention also has its object to provide a foamed product using the thermally expandable microcapsule. The present invention relates to a thermally expandable microcapsule, which comprises: a shell made of a polymer; and a volatile expansion agent as a core agent encapsulated in the shell, the storage elastic modulus (E′) of the shell at a temperature of 200° C. and a frequency of 10 Hz being 1×10 | 2011-10-27 |
20110263747 | MULTIFUNCTIONAL ENCODED PARTICLES FOR HIGH-THROUGHPUT ANALYSIS - Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region. | 2011-10-27 |
20110263748 | PROCESS FOR PRODUCING CROSSLINKED ORGANIC POLYMERS - The invention relates to a process for producing crosslinked organic polymers by reacting a polymer with a crosslinking agent from the group of the substituted cyanurates and isocyanurates, and also to novel compounds from the said group. | 2011-10-27 |
20110263749 | USE OF CSH SUSPENSIONS IN WELL CEMENTING - The use of a setting accelerator composition for inorganic binders which comprises at least one water-soluble comb polymer suitable as a superplasticizer for hydraulic binders and calcium silicate hydrate particles in the development, exploitation and completion of underground mineral oil and natural gas deposits and in deep wells is proposed. | 2011-10-27 |
20110263750 | Tire with a Tread Comprising an SNBR Elastomer - The present invention relates to a tyre having a tread comprising a rubber composition that comprises at least:
| 2011-10-27 |
20110263751 | Highly Hydrophobic Coatings - The invention relates to a suspension comprising: fine-particulate particles in an amount of 0.01-50 wt %, wherein the particles have a fractal mass dimension D | 2011-10-27 |
20110263752 | AQUEOUS INK FOR INKJET RECORDING - The present invention provides [1] a water dispersion for ink-jet printing containing chain-like particles each containing anionic organic pigment particles and a cationic polymer, wherein the ratio of organic pigment primary particles forming the chain-like particles to all the pigment primary particles contained in the water dispersion is 10% by number or more; [2] a water-based ink for ink-jet printing containing the water dispersion; [3] a method for producing a water dispersion for ink-jet printing as described above in [1]; and [4] a water-based ink for ink-jet printing containing a water dispersion produced through the method. The water dispersion and water-based ink for ink-jet printing of the present invention realize excellent optical density. | 2011-10-27 |
20110263753 | WATER DISPERSIBLE EPOXY URETHANE COMPOUNDS AND COATING COMPOSITIONS - The invention relates to novel aqueous coating compositions containing epoxy urethane (glycidyl carbamate) functional resin. An aqueous coating composition comprises a polyfunctional oligomer having at least two epoxy urethane functional groups and a polyalkylene oxide chain, an optional surfactant, and water. The aqueous coating compositions of the invention can be dispersed in water with or without added surfactants to form a dispersion containing no volatile organic solvent. The invention provides a method for making aqueous coating compositions containing epoxy urethane functional resin as well. Water-dispersible epoxy urethane compounds of the aqueous coating compositions are also provided. | 2011-10-27 |
20110263754 | METALLIC COMPOUNDS IN NON-BROMINATED FLAME RETARDANT EPOXY RESINS - A composition comprising a) an epoxy resin; b) a hardener; and c) a stabilizer comprising a metal-containing compound, the metal-containing compound comprising a metal selected from the Group 11-13 metals and combinations thereof, and wherein said composition contains a non-halogen flame retardant is disclosed. | 2011-10-27 |
20110263755 | USE OF SURFACTANT IN THE PREPARATION OF MODIFIED SULFUR AND SULFUR CEMENT - Use of a non-ionic surfactant in the preparation of modified sulfur and/or modified sulfur cement that may or may not be modified sulfur concrete. | 2011-10-27 |
20110263756 | MOLDING MATERIAL CONTAINING UNSATURATED POLYESTER RESIN AND MICROFIBRILLATED PLANT FIBER - The present invention relates to a molding material comprising an unsaturated polyester resin and microfibrillated plant fibers, the microfibrillated plant fibers comprising cellulose and hemicellulose, and having a specific surface area of 5 to 20 m | 2011-10-27 |
20110263757 | DURABLE THERMOSET BINDER COMPOSITIONS FROM 5-CARBON REDUCING SUGARS AND USE AS WOOD BINDERS - The present invention provides thermosetting aqueous binder compositions of (i) one or more diprimary diamine, e.g. lysine, or poly(primary amine), e.g. polyethylenimine and tris(2-aminoethyl)amine, and (ii) one or more 5-carbon reducing sugar, such as xylose. The binders are at least substantially formaldehyde free and cure rapidly at temperatures sufficiently low and with sufficiently little swelling to enable one to provide wood or woody material containing articles, such as particle board, oriented strand board and bamboo boards or articles. | 2011-10-27 |
20110263758 | Composites Made of Thermoplastic Polymers, Residual Oil, and Cellulosic Fibers - A method is disclosed for recycling polymer containers contaminated with oil, for example used HDPE motor oil containers, in an energy efficient manner, that does not require a costly washing step. The commercial value of the polymers is preserved by converting the contaminated polymers into value-added products. Composites are made from discarded motor oil containers, the residual motor oil therein, cellulosic fibers, and blending agents or other additives. In one embodiment, the process uses the residual oil to advantage as a fiber blending agent, or to make polymer types in a blend more compatible with one another. | 2011-10-27 |
20110263759 | INK EXTENDERS AND INKS UTILIZING ORGANIC BASED RESINS - An extender for flexographic and other ink compositions and inks using such extender where potato starch serves as the ink carrier and an emulsion resin. The use of potato starch provides for a readily available, cost effective, substantial and environmentally friendly alternative to petroleum and soy based resins. | 2011-10-27 |
20110263760 | ALKYLPHENOL FREE - LIQUID POLYMERIC PHOSPHITE POLYMER STABILIZERS - An alkylphenol-free liquid polymeric phosphite is described of general Structure IV illustrated below | 2011-10-27 |
20110263761 | RUBBER-METAL COMPOSITE AND PNEUMATIC TIRE USING THE SAME - The present technology provides a rubber-metal composite having high water resistant adhesion strength and a pneumatic tire using the same by providing a rubber-metal composite having metal reinforcing cords embedded in a rubber composition including from 0.05 to 10 parts by mass of a benzothiazole anticorrosive and/or a benzotriazole anticorrosive per 100 parts of a diene rubber. The present technology also provides a pneumatic tire using the rubber-metal composite. | 2011-10-27 |
20110263762 | POLYLACTIC ACID COMPOSITION AND MOLDED ARTICLE THEREOF - A composition comprising polylactic acid and having excellent heat stability, especially moist heat stability, and a molded article thereof. | 2011-10-27 |