43rd week of 2011 patent applcation highlights part 43 |
Patent application number | Title | Published |
20110262957 | COMPOSITIONS FOR THE DETECTION OF INTRACELLULAR BACTERIAL TARGETS AND OTHER INTRACELLULAR MICORORGANISM TARGETS - Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in added form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an intracellular bacterial target) utilizing such solid supports. Further, presented herein are tablets as well as dry powders comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent), and methods of using such tablets and dry powders to detect the presence of an intracellular microorganism target (e.g., an intracellular bacterial target). | 2011-10-27 |
20110262958 | DEVICE FOR EXAMINING MYOCARDIAL TOXICITY, CHIP FOR EXAMINING MYOCARDIAL TOXICITY AND METHOD FOR EXAMINING MYOCARDIAL TOXICITY - [Problem] To provide a device and a method for examining myocardial toxicity, which can be realized in vitro in an equivalent manner as those conventionally carried out in vivo. | 2011-10-27 |
20110262959 | METHOD FOR EVALUATION OF DIFFERENTIATION ABILITY OF STEM CELL - The present invention provides a method of evaluating the possibility of a stem cell being able to differentiate into a cell that constitutes a desired tissue in a living organism, comprising the following steps of:
| 2011-10-27 |
20110262960 | MYCOBACTERIA CULTURE MEDIUM AND METHOD INCLUDING MYCOBACTERIA OF MYCOBACTERIUM TUBERCULOSIS COMPLEX - The present invention relates to a novel mycobacteria culture medium, particularly for mycobacteria of the | 2011-10-27 |
20110262961 | Diagnosis, Prevention and Treatment of Disorders Characterized by Undesirable Cell Proliferation - The present invention relates to compositions and methods for the reduction of atherosclerotic plaques and the decrease in the level of total serum cholesterol, triglycerides, serum LDL cholesterol, and serum HDL cholesterol. The present invention also relates to methods for the diagnosis, prevention and treatment of atherosclerosis and mycoplasma associated diseases. | 2011-10-27 |
20110262962 | METHOD FOR PRODUCING PEPTIDES - The present invention provides a method for producing a peptide, comprising culturing a transformant introduced with an expression vector to prepare a culture, and mixing the culture with a carboxy component and an amine component to form the peptide. The expression vector comprises a polynucleotide encoding a protein: (A) having selected deletions in the amino acid sequence of SEQ ID NO:2, (B) having a mutation of one or several amino acid residues in any protein selected from said group (A); (C) having 70% or more amino acid sequence identity to any protein selected from said group (A), (D) encoded by a polynucleotide that hybridizes under a stringent condition with a polynucleotide consisting of a nucleotide sequence complementary to a polynucleotide encoding any protein selected from said group (A), and (E) encoded by a polynucleotide having 70% or more nucleotide sequence identity to the polynucleotide encoding any protein selected from the group (A). | 2011-10-27 |
20110262963 | BIOSYNTHETICALLY GENERATED PYRROLINE-CARBOXY-LYSINE AND SITE SPECIFIC PROTEIN MODIFICATIONS VIA CHEMICAL DERIVATIZATION OF PYRROLINE-CARBOXY-LYSINE AND PYRROLYSINE RESIDUES - Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. | 2011-10-27 |
20110262964 | Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use - The present invention relates to reagentless fluorescent biosensors which comprise at least one ankyrin repeat and a fluorophore and are specific for at least one target; the method for preparing such reagentless fluorescent biosensors comprises the following steps: (a) identifying the residues (R | 2011-10-27 |
20110262965 | CELL CULTURE MEDIUM COMPRISING SMALL PEPTIDES - Cell culture media, concentrated media and feeds, methods of manufacturing cell culture media and feeds, and methods of culturing cells are provided. One or more small peptides, including dipeptides are added to the cell culture media to provide improved stability and improved conditions for culturing cells. | 2011-10-27 |
20110262966 | DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS - Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in | 2011-10-27 |
20110262967 | USE OF HSA-PRODUCING CELLS - The present invention refers to the area of cell culture technology and relates to methods for multiplying/cloning cells, preferably cell lines, which are important to the production of biopharmaceuticals. The invention further relates to methods for manufacturing proteins and to the use of cells extracted and multiplied through single cell sorting and to media compositions that enable a multiplication of single cells. Through the use of albumin-producing, preferably HSA-producing, cells as feeder cells for the conditioning of medium or as host cells, the recloning efficiency and thereby the quantity of clones obtained can be significantly increased. A combination of these approaches is also possible. Through the use of albumin-producing, preferably HSA-producing, cells, an increase in the recloning efficiency can be achieved in serum-free and/or insulin-free medium as well, and in different cell types. | 2011-10-27 |
20110262968 | ANTIBODIES THAT BIND TO PSCA PROTEINS FOR DIAGNOSIS OF CANCER - Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization. | 2011-10-27 |
20110262969 | METHOD FOR PRODUCING OPTICALLY ACTIVE, CYCLIC DEPSIPEPTIDES COMPRISING LACTIC ACID AND PHENYL LACTIC AND HAVING 24 RING ATOMS, USING FUNGUS STRAINS OF ROSELLINIA TYPE, AND FURTHER SPECIES OF XYLARIACEAE - The present invention relates to a process for the preparation of lactic- and phenyllactic-acid-containing, optically active, cyclic depsipeptides with 24 ring atoms by means of fungal strains of the genus | 2011-10-27 |
20110262970 | Enzymatic Hydrolysis Of Pretreated Lignocellulose-Containing Material With Cationic Polysaccharides - A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing a cationic polysaccharide to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of a first hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation product. The cationic polysaccharide may be a cationic starch. | 2011-10-27 |
20110262971 | Genetically Modified E. coli Strains for Producing Erythromycin - Genetically modified | 2011-10-27 |
20110262972 | Chondroitin Synthase, Method for Producing the Same and Method for Producing Saccharide Chain-Extended Chondroitin - A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human chondroitin synthase, it is possible to produce a saccharide chain having a repeating disaccharide unit of chondroitin. The DNA or part thereof may be used as a probe for hybridization for the human chondroitin synthase. | 2011-10-27 |
20110262973 | Methods and Compositions for DNA Manipulation - single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a cassette containing at least one nicking site and at least one restriction site at a predetermined distance from each other and in a predetermined orientation; or primer-dependent amplification which introduces into a polynucleotide molecule, a modified nucleotide which is excised to create a nick using a nicking agent. The methods and compositions provided can be used to manipulate a DNA sequence including introducing site specific mutations into a polynucleotide molecule and for cloning any polynucleotide molecule or set of joined polynucleotide molecules in a recipient molecule such as a vector of choice. | 2011-10-27 |
20110262974 | Novel enzymes for use in enzymatic bleaching of food products - The present invention relates to novel polypeptides according to caroase 01-05 or any functional equivalents of any of them, suitable for use in a method for preparing a food products having increased whiteness, the use of the enzyme to increase whiteness of at least part of a food product, a process for preparing a food product wherein the enzyme is used and the food product obtained. | 2011-10-27 |
20110262975 | ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST - The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof. | 2011-10-27 |
20110262976 | PRODUCTION OF R-a-LIPOIC ACID BY FERMENTATION USING GENETICALLY ENGINEERED MICROORGANISMS - This application provides systems and methods for the production of R-α-lipoic acid. Lipoic acid synthesis genes may be expressed in an acid-tolerant microorganism, such as | 2011-10-27 |
20110262977 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINE DERIVATIVE - Optically active amine derivatives are produced by acting on imine derivatives with a culture of microorganisms having the ability to stereoselectively reduce the compounds, microbial cells, or processed products thereof, followed by collecting the generated optically active amine derivatives. Optically active amine derivatives obtained in the present invention are useful as materials for pharmaceutical agents. The present invention enables, for example, production of an optically active compound represented by formula (IV): | 2011-10-27 |
20110262978 | EXPRESSION VECTOR FOR PSEUDONOCARDIA AUTOTROPHICA - An expression vector capable of expressing a foreign gene in | 2011-10-27 |
20110262979 | NOVEL COMPOSITION OF MATTER FOR USE IN PRODUCING CO-ENZYME Q10 AND A NOVEL METHOD FOR PRODUCING CO-ENZYME Q10 - The present invention provides materials and methods for the growth of microorganisms for the production of organic chemicals, for example, coenzyme Q10. | 2011-10-27 |
20110262980 | MICRO-ORGANISMS FOR THE PRODUCTION OF ACETOL OBTAINED BY A COMBINATION OF EVOLUTION AND RATIONAL DESIGN - The present invention concerns a new method combining evolution and rational design for the preparation of a strain of micro-organism for the production of acetol from a simple carbon source. The said method comprises:
| 2011-10-27 |
20110262981 | CAROTENOID FERMENTATION METHOD - The present invention provides a method for producing a carotenoid, which comprises culturing a carotenoid-producing bacterium in an amino acid-supplemented medium, and collecting the carotenoid from the resulting cultured product, wherein the amino acid is at least one selected, from the group consisting of glutamic acid, aspartic acid, glutamine, asparagine, alanine, glycine, serine, threonine, arginine, tyrosine, proline, phenylalanine and leucine, and salts thereof | 2011-10-27 |
20110262982 | ACETOLACTATE SYNTHASE HAVING 2-KETOISOVALERATE DECARBOXYLASE ACTIVITY AND USES THEREOF - Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol, and 2-phenylethanol from a suitable substrate and a recombinant acetolactate synthase having both synthase and decarboxylase activity. | 2011-10-27 |
20110262983 | METABOLICALLY ENGINEERED YEASTS FOR THE PRODUCTION OF ETHANOL AND OTHER PRODUCTS FROM XYLOSE AND CELLOBIOSE - The present invention provides yeast cells that produce high concentrations of ethanol, culture media and bioreactors comprising the yeast cells, and methods for making and using the yeast cells in efficiently producing ethanol. | 2011-10-27 |
20110262984 | METHOD FOR PRODUCING ETHANOL AND CO-PRODUCTS FROM CELLULOSIC BIOMASS - The present invention generally relates to processes for production of ethanol from cellulosic biomass. The present invention also relates to production of various co-products of preparation of ethanol from cellulosic biomass. The present invention further relates to improvements in one or more aspects of preparation of ethanol from cellulosic biomass including, for example, improved methods for cleaning biomass feedstocks, improved acid impregnation, and improved steam treatment, or “steam explosion.” | 2011-10-27 |
20110262985 | PROCESSING BIOMASS - Methods are provided for changing a molecular structure of a biomass feedstock. The methods include a screw extrusion process. | 2011-10-27 |
20110262986 | BIOLOGICAL SOLAR PANEL DEVICES, ARRAYS, METHODS AND SYSTEMS FOR THE COLLECTION OF VOLATILE ORGANIC MOLECULES - Provided herein are devices, arrays, methods, systems, and other subject matter comprising a biological solar panel device comprising: (a) a layer comprising a material is transparent or translucent to light; (b) a photosynthetic layer comprising a material that uses carbon dioxide and water in the presence of sunlight to release a volatile organic molecule, wherein the photosynthetic layer is separated from the transparent or translucent material by a gas layer; and (c) a layer that provides support for the material that releases a volatile organic molecule. | 2011-10-27 |
20110262987 | Solubilization of Carbonaceous Materials and Conversion to Hydrocarbons and Other Useful Products - Methods of producing useful products, such as hydrocarbons and other molecules that are useful as fuels, from carbonaceous materials, are disclosed. Such methods include obtaining a carbonaceous material, such as coal, from a deposit and treating the carbonaceous material with one or more chemicals, including acetic acid, salts of acetic acid, esters of acetic acid, hydroxides and peroxides, alone or in combination, to solubilize the material in preparation for further processing, such as bioconversion, to produce useful products, or solubilizing the carbonaceous material in a formation using the above-recited chemicals, removing the solubilized material from the formation and bioconverting it to produce useful products, or solubilizing the material using the above-recited chemicals and bioconverting at least a portion of the solubilized material in a formation followed by recovery of useful products from the formation. | 2011-10-27 |
20110262988 | METHODS AND COMPOSITIONS FOR ENHANCED BACTERIAL HYDROLYSIS OF CELLULOSIC FEEDSTOCKS - The present invention provides compositions comprising a cellulolytic bacterium and an isolated BETA-glucosidase enzyme or comprising cellulolytic bacterium that expresses a secreted recombinant BETA-glucosidase enzyme, and methods of using same for hydrolysis of cellulose and cellulosic feedstocks. | 2011-10-27 |
20110262989 | ISOLATING A TARGET ANALYTE FROM A BODY FLUID - The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a body fluid sample. In certain embodiments, methods of the invention involve introducing magnetic particles including a target-specific binding moiety to a body fluid sample in order to create a mixture, incubating the mixture to allow the particles to bind to a target, applying a magnetic field to capture target/magnetic particle complexes on a surface, and washing with a wash solution that reduces particle aggregation, thereby isolating target/magnetic particle complexes. | 2011-10-27 |
20110262990 | ACOUSTIC DEVICE AND METHODS THEREOF FOR SEPARATION AND CONCENTRATION - The invention provides a settling device comprising an acoustic wave generator and an inclined settling chamber. The angle θ between the acoustic wave direction and the inclined settling chamber is greater than 0 and less than 90°. The invention also provides a concentration method and a separation method using the device. The invention can be used to concentrate or separate particles such as inorganic particles, organic particles, and biological particles, for example, mammalian cells, bacteria, yeast, algae, and plant cells. The invention exhibits technical merits such as higher efficiency, cost-effectiveness, and large-scale production. | 2011-10-27 |
20110262991 | Living Copolymer-Protein/Peptide Hybrids for Biomedical Applications - Water soluble polymers having formula I: Y-(L | 2011-10-27 |
20110262992 | METHOD FOR STABILIZING LABELED ANTIBODY - The present invention relates to a method for stabilizing a labeled antibody in a solution, in which the labeled antibody is stabilized by allowing the labeled antibody to be present together with at least one of amino acid and a derivative thereof in the solution. | 2011-10-27 |
20110262993 | METHOD FOR PREPARING A CELLULAR CARBON MONOLITH COMPRISING A HIERARCHISED POROUS NETWORK - A carbon or ceramic monolithic materials with an M2 (macroporous/microporous) hierarchised porous structure is provided as well as method for preparing said materials using a macro/meso/microporous silica cavity. Such materials may be used, in particular for the production of hydrogen purifiers, supercapacitors or electrodes, or else for carrying out catalysed chemical reactions in a heterogeneous phase. | 2011-10-27 |
20110262994 | NOVEL REAGENTS AND METHOD FOR CONJUGATING BIOLOGICAL MOLECULES - A compound of the general formula X-[Q-W—(CH═CH) | 2011-10-27 |
20110262995 | GRG32: A Novel EPSP Synthase Gene Conferring Herbicide Resistance - Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, the present invention provides for isolated nucleic acid molecules comprising the nucleotide sequence set forth in SEQ ID NO:1 or 14, a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:2, the herbicide resistance nucleotide sequence deposited in a bacterial host as Accession Nos. NRRL B-30931, as well as variants and fragments thereof. | 2011-10-27 |
20110262996 | METHODS AND MATERIALS FOR DEGRADING PYRETHROID - Methods and compositions are provided for enzymatic detoxification of pyrethroid such as permethrin. The methods involve application of compositions of organophosphorus hydrolase OPH to surfaces or substances contaminated with pyrethroid such as permethrin. | 2011-10-27 |
20110262997 | PRODUCTION OF CELLULASE - The invention relates to a process of producing cellulase in a host cell, comprising cultivating said host cell capable of producing cellulase under conditions conducive for production of cellulase, wherein pre-treated ligno-cellulosic material is added to induce cellulase production. The invention also relates to use of pre-treated ligno-cellulosic material as inducer or carbon source in cellulase production processes. | 2011-10-27 |
20110262998 | PROCESS FOR PREPARING INCLUSION BODY-FORMING PROTEIN - A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment consisting of a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest, and a process for preparing an inclusion body-forming protein consisting of the following steps: (1) preparing an expression vector in which a nucleic acid fragment is incorporated consisting of a nucleotide sequence coding for a modified signal peptide downstream of which is bound a nucleotide sequence of a gene of a protein of interest, (2) preparing a host cell transformed with the expression vector that produces an inclusion body-forming protein, and (3) purifying the inclusion body-forming protein from culture obtained by culturing the host cell that produces the inclusion body-forming protein. The above other amino acid is selected from the group consisting of aspartic acid, glutamic acid, lysine, histidine, phenylalanine and tyrosine. | 2011-10-27 |
20110262999 | Compositions and Methods Comprising Protease Variants - The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions. | 2011-10-27 |
20110263000 | A THROMBIN-LIKE ENZYME OF AGKISTRODON ACUTUS - A thrombin-like enzyme isolated from Agkistrodon acutus venom, comprising an alpha subunit having the sequence of SEQ ID No. 1 and a beta subunit having the sequence of SEQ ID No. 2, which are linked by seven disulfide bonds, is provided. The hemocoagulase of | 2011-10-27 |
20110263001 | Compositions and Methods for Engineering Cells - The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells. | 2011-10-27 |
20110263002 | COMPOSITIONS AND METHODS FOR CONTINUOUS HARVESTING OF SUSPENSION GROWTH CULTURES - Embodiments herein concern compositions, methods and uses for harvesting suspension cultures or decontaminating waters. In certain embodiments, suspension microorganism cultures can comprise algal cultures. In some embodiments, harvesting suspension cultures may include using a composition capable of interacting with the culture in order to separate the culture from a liquid or media. | 2011-10-27 |
20110263003 | Microbacterial Peptide Deformylase - The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from | 2011-10-27 |
20110263004 | Method of treating biomass - Method of treating a biomass containing a fibrous structure and polysaccharides. According to the method the biomass is subjected to extractive treatment at which it is heated in aqueous phase at an absolute pressure of over 0.6 MPa and a temperature of at least 160° C. for separating polysaccharides from the mass. According to the invention, the pH of the biomass which is subjected to the extractive treatment is not actively lowered during the extraction and after the treatment the pressure is controllably reduced so as not to decompose the fibrous structure of the biomass. The polysaccharides separated from the mass are recovered as a first fraction, the fibrous structure of the biomass as a second fraction and at least one of the fractions is subjected to further processing. By means of the invention it is possible to isolate from the starting materials valuable compounds and groups of compounds by a method suitable for use on an industrial scale. | 2011-10-27 |
20110263005 | PIPETTE TIP FOR ELECTROPORATION DEVICE - Provided herein is a pipette tip ( | 2011-10-27 |
20110263006 | INTEGRATED TEST STRIP CONTAINER WITH RETAINING INSERT - A blood glucose meter for providing easy access to test strips and measuring blood glucose, a disposable and removable cartridge for providing easy access to test strips, and methods of manufacturing and utilization thereof are disclosed. The blood glucose meter for providing easy access to test strips and measuring blood glucose has a disposable and removable cartridge, a retaining member which releasably retains the test strips in a stacked configuration, and a housing. The disposable and removable cartridge has a rigid lid attached to a flexible body. | 2011-10-27 |
20110263007 | DEVICE, KIT AND METHOD FOR PULSING BIOLOGICAL SAMPLES WITH AN AGENT AND STABILISING THE SAMPLE SO PULSED - A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology. | 2011-10-27 |
20110263008 | Cell Culture Real-Time Observation System - The present invention discloses a cell culture realtime observation system comprising a plate, a culture well, an image capture device, at least one container, an evaporation device, a first micro channel, a second micro channel and a transmission unit. The culture well is disposed on the plate, and the image capture device is disposed between the plate and the culture well. The container is disposed on the plate and at a side of the culture well, and the evaporation device is disposed at the other side of the culture well. The container and the culture well are connected by the first micro channel, and the culture well and the evaporation device are connected by the second micro channel. The transmission unit is electrically connected to the image capture device. | 2011-10-27 |
20110263009 | METHOD FOR THE FILTRATION OF A BIOREACTOR LIQUID FROM A BIOREACTOR; CROSS-FLOW MEMBRANE MODULE, AND BIOREACTOR MEMBRANE SYSTEM - The invention provides a method for the filtration of a bioreactor liquid ( | 2011-10-27 |
20110263010 | INCUBATOR DEVICE AND METHOD - The invention provides an incubation device, comprising an incubator chamber ( | 2011-10-27 |
20110263011 | ANTIFOULING COATING COMPOSITION COMPRISING FUNCTIONALIZED NANOPARTICLES - Method for providing a substrate with an anti-biofouling coating the method comprising: a. obtaining a coating composition comprising nanoparticles being grafted with reactive groups and hydrophilic polymer chains and a solvent; b. applying the coating composition to the substrate; and c. optionally curing the coating composition herein the surface tension of the coating composition at 25° C. is below 40 mN/m. | 2011-10-27 |
20110263012 | SCREENING AND THERAPEUTIC METHOD FOR NSCLC TARGETING CDCA1-KNTC2 COMPLEX - The present invention is based on the observation that the co-activation of CDCA1 and KNTC2, and their cognate interactions, play significant roles in lung-cancer progression and that methods of inhibiting the complex can be used to treat non-small-cell lung cancer. | 2011-10-27 |
20110263013 | Compositions And Methods For Growing Embryonic Stem Cells - Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing human umbilical cord blood derived stem cells or secreted proteins obtained from the culture medium of human umbilical cord blood derived stem cells. | 2011-10-27 |
20110263014 | Cleavage of Nanog by Caspases Mediates the Differentiation of Embryonic Stem Cells - The present invention is based on the discovery that a caspase specifically cleaves the transcription factor, Nanog, leading to the initiation of cellular differentiation of embryonic stem (ES) cells. The present invention includes a method of inhibiting the cleavage of Nanog, thereby maintaining the pluripotency of an ES cell or preventing the differentiation of an ES cell. The present invention further provides compositions and methods for inhibiting caspase expression, activity, and/or stability. | 2011-10-27 |
20110263015 | COMPOSITIONS AND METHODS FOR GENERATION OF PLURIPOTENT STEM CELLS - The present invention describes the use of pre-trans-splicing molecules (PTMs) to reprogram human normal and diseased somatic cells into pluripotent stem cells using spliceosome-mediated RNA trans-splicing. More specifically, the present invention describes the use of the SMaRT™ technology to repair or reprogram the newly induced diseased pluripotent stem cells. | 2011-10-27 |
20110263016 | Expansion of Embryonic Stem Cells - The present invention addresses the problem of expanding human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC) populations to clinically relevant numbers while maintaining pluripotency. In particular, the use of macrolide antibiotics and inhibitors of Rho and Rho-associated kinases is described. | 2011-10-27 |
20110263017 | TECHNIQUE FOR REGULATING REGENRATION OF TISSUE OR FAULTY OR ABNORMAL PART IN ORGAN USING NELL-1 - The object aims to form and maintain a cell, a tissue or an organ induced by differentiation. Disclosed is a composition for inducing the differentiation of a cell capable of being differentiated in a given direction to thereby produce a cell, a tissue or an organ through the further induction of the differentiation in the given direction. The composition comprises NELL-1 or a substance which can be altered so as to act as NELL-1 upon the differentiation. Also disclosed is a composition for maintaining a cell, a tissue or an organ produced by the induction of the differentiation. | 2011-10-27 |
20110263018 | CORE-SHELL STRUCTURED DELIVERY SYSTEM FOR GROWTH FACTORS, A PREPARATION METHOD THEREOF, AND USE THEREOF FOR THE DIFFERENTIATION OR PROLIFERATION OF CELLS - The present invention relates to a method of preparing a delivery system capable of loading bioactive growth factors that are essential for the differentiation and proliferation of cells and is characterized as loading at least two types of components comprising growth factors in a single carrier, whereby the release of each of the plurality of growth factors can be temporally controlled. Specifically, the method of preparing a microcapsule type growth factor delivery system according to the present invention includes: (1) preparing a polymeric microsphere comprising a first component, and then encapsulating the microspheres by electrodropping the polymer microsphere into another polymer comprising a second component, thereby manufacturing a core-shell structured, microcapsule type delivery system, or (2) encapsulating a polymer solution comprising a first component by electrodropping the polymer solution into another polymer comprising a second component, thereby manufacturing a core-shell structured microcapsule type delivery system. The present invention also provides a stem cell differentiation method involving bringing a microcapsule type delivery system loaded with multiple growth factors according to the present invention into contact with stem cells. | 2011-10-27 |
20110263019 | Method of Reseeding Adherent Cells Grown in a Hollow Fiber Bioreactor System - This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor. | 2011-10-27 |
20110263020 | MEMBRANE FOR CELL EXPANSION - A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells. | 2011-10-27 |
20110263021 | METHOD AND DEVICE FOR INDUSTRIAL BIOLAYER CULTIVATION - A compact, high-yield, bio-reactor for use as small, medium and large-scale production unit for therapeutic proteins, proteins in general and enzymes based on controlled activity of the cells or micro organisms and the production of such as high value antibodies for pharmaceutical and/or bio-diagnostic applications. | 2011-10-27 |
20110263022 | IRRADIATED MEMBRANE FOR CELL EXPANSION - A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells. | 2011-10-27 |
20110263023 | GENES FOR MODULATING COFFEE MATURATION AND METHODS FOR THEIR USE - Disclosed are isolated nucleic acids for modulating coffee maturation. Also disclosed are promoters derived from such genes. Methods for using the nucleic acids for improving quality attributes of coffee are provided. Also provided are methods for assessing the quality of plant-based agricultural products, such as coffee. | 2011-10-27 |
20110263024 | PROCESS OF CLEAN CLONING - A process of inserting a nucleic acid sequence of interest into an acceptor nucleic acid, comprising the following steps:
| 2011-10-27 |
20110263025 | BIODEGRADABLE POLYDISULFIDE AMINES FOR GENE DELIVERY - Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(N,N′-cystaminebisacrylamide-spermine), poly(N,N′-cystaminebisaciylamide-N,N′-bis(3-aminopropyl)1,3-propanediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(3-amino-propyl)ethylenediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(2-aminoethyl)-1,3-propanediamine), and poly(N,N′-cystaminebisacrylamide-triethylenetetramine). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and protected oligoamine monomers, followed by deprotection. Complexes are formed by mixing the poly(disulfide amine)s with a nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes. | 2011-10-27 |
20110263026 | Construction of Protein-Responsive shRNA/RNAi Control System Using RNP Motif - An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence complementary to a target sequence; a passenger strand which forms a duplex with the guide strand; and a linker strand which links the guide strand and the passenger strand, wherein the linker strand comprises an RNP-derived protein-binding motif sequence. The present invention also provides an RNAi control system comprising: the shRNA; and an RNP-derived protein which specifically binds to a protein-binding motif sequence in the shRNA. | 2011-10-27 |
20110263027 | Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby - Adeno-associated virus 7 sequences, vectors containing same, and methods of use are provided. | 2011-10-27 |
20110263028 | MEGANUCLEASE RECOMBINATION SYSTEM - The invention relates to a set of genetic constructs which allow the efficient and reproducible introduction of a specific nucleotide sequence at a fixed position in the genome by generating a double strand break at a specific position in the genome using a meganuclease and so stimulating a homologous recombination event at this locus between the genomic site and a transfected donor sequence. The present invention also relates to methods using these constructs and to these materials in the form of a kit. | 2011-10-27 |
20110263029 | Methods And Kits For The Determining The Presence Or Absence Of Ergot Alkaloids - The present invention is directed to methods and kits for the determining the presence or absence of ergot alkaloids in sample which use chromatographic instrumentation and columns operating at a pressure of 4,000 to 15,000 psi and columns with 1-3 micron particle size to produce results by mass spectroscopy in approximately four minutes. | 2011-10-27 |
20110263030 | CENTRIFUGAL MICRO-FLUIDIC DEVICE AND METHOD FOR DETECTING ANALYTES FROM LIQUID SPECIMEN - A centrifugal micro-fluidic device detecting analytes in a liquid specimen and a method of detection of analytes from a liquid specimen using the micro-fluidic device are provided. Reaction efficiency is increased using a repetitive flow of the liquid specimen induced by an alternating combination of capillary force and centrifugal force, thereby enhancing detection sensitivity. | 2011-10-27 |
20110263031 | Process, Portable Equipment and Device for In Vitro, One-Step Photometric Determination of Hemoglobin Concentration in a Diluted Blood Sample - A process, portable equipment and device for in vitro photometric determination of hemoglobin concentration in diluted blood. The present invention allows its use in field anemias prospection programs. The present invention has a light source ( | 2011-10-27 |
20110263032 | Testing Mechanical Hardware for Wear and a Composition - The present invention discloses a method and composition for testing the wear on mechanical hardware. During the testing method a metal oxidant is applied the mechanical hardware being tested which deposits onto the mechanical and can be visually detected. One of the properties of the metal oxidant is that it is a substantially non-flow or non-drip medium that can be applied in situ with reduced risk to surrounding hardware. | 2011-10-27 |
20110263033 | Apparatus And Methods For Performing Photoreactions And Analytical Methods And Devices To Detect Photo-Reacting Compounds - Embodiments of the present invention are directed to devices and methods for performing photoreactions of photo-reacting compounds in solution. The invention features a vessel and a light source. The vessel has at least one wall defining a chamber. The chamber, for performing photoreactions, has a chamber volume, a first window, an inlet and an outlet. The inlet and outlet are in fluid communication with a source of photo-reacting compounds in solution. The first window is transparent to light transmission and is placed in optical communication with a light source to receive photons. The chamber is for receiving a solution over time to define a dwell time. The solution potentially has one or more photo-reactive compounds having a concentration. The device further comprises a light source, in optical communication with the first window, for emitting photons which photons are received by the first window and transmitted into the chamber. | 2011-10-27 |
20110263034 | METHOD AND DEVICE FOR FAST SULFUR CHARACTERIZATION AND QUANTIFICATION IN SEDIMENTARY ROCKS AND PETROLEUM PRODUCTS - The invention relates to a method and to a device for sulfur characterization and quantification in a sample of sedimentary rocks or of petroleum products wherein the following stages are carried out: heating said sample in a pyrolysis oven ( | 2011-10-27 |
20110263035 | DETERMINING OXYGEN CONCENTRATION IN ULLAGE USING CATALYTIC OXIDATION - A system for measuring the oxygen concentration of a gas includes a catalytic reactor, first and second temperature sensors and a control unit. The catalytic reactor includes a combustion catalyst that supports the catalytic combustion of hydrocarbon fuel vapor in a gas stream. The first temperature sensor is located upstream of the catalytic reactor for sensing an upstream temperature of the gas stream, and the second temperature sensor is located downstream of the catalytic reactor for sensing a downstream temperature of the gas stream. The control unit compares the upstream temperature and the downstream temperature to determine the oxygen concentration of the gas stream. | 2011-10-27 |
20110263036 | AMORPHOUS THIN FILM FOR SENSING - An apparatus and method for low-power sensing, for example, sensing of chemical or biochemical analytes in a gas or liquid phase are disclosed. One aspect relates to the use of a thin continuous film without grain boundaries as a sensing layer in devices for sensing a predetermined analyte and to low power devices having such sensing layer. The sensing layer has a surface exposed to the analyte. The electrical impedance of the sensing layer changes upon adsorption of the predetermined analyte on the exposed surface of the sensing layer. The sensing layer may have a thickness in the range between about 1 nm and 100 nm, such as between about 1 nm and 30 nm. The sensing layer may be an amorphous layer. | 2011-10-27 |
20110263037 | POLYMERIC MATERIALS INCORPORATING CORE-SHELL SILICA NANOPARTICLES - Fibers, fabrics and textiles in which core-shell silica nanoparticles are incorporated are provided. The fibers, fabrics and textiles can be polymeric materials or natural cellulose-based or protein-based materials in which core-shell silica nanoparticles are incorporated. A variety of polymeric and natural materials can be employed, such as cellulose acetate, nylon, rayon, modacrylic, olefin, acrylic, polyester, polylactic acid, polylactic-co-glycolic acid (PLGA), polyurethane, aramid, wool, cotton, ramie, milk protein, soy protein, bamboo, etc. The core-shell silica nanoparticles can incorporate sensing, magnetic, thermal, electrical, chemical or RFID properties that can be imparted to the materials and that allow the materials to sense one or more conditions of interest, making them ideal for in situ sensing, treatment, or security applications. | 2011-10-27 |
20110263038 | PUNCH SAMPLING APPARATUS AND METHOD - A punching apparatus ( | 2011-10-27 |
20110263039 | LIQUID CONTAINER WITH VARIABLE EXTRACTION CHIMNEY - A liquid container having a top opening, a base, and an extraction chimney which extends into the container and which is in alignment with the top opening is presented. The extraction chimney is intended for the withdrawal of liquid by a liquid-withdrawal element that is introduced into the liquid container through the extraction chimney. The extraction chimney has a liquid-permeable zone in its bottom region, adjacent to the liquid container base. The liquid permeability of the liquid-permeable zone of the extraction chimney can be adjusted between a setting for minimal liquid permeability and a setting for greater liquid permeability. The extraction chimney can be adjusted while the extraction chimney remains in the liquid container. | 2011-10-27 |
20110263040 | DEVICES AND METHODS FOR REDUCING MATRIX EFFECTS - Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding matrix interfering agents present in the bioanalytical sample, wherein the device further comprises filtering means for removing precipitated protein particles. The filtering means is a size exclusion filter or a polymeric or inorganic monolith having a maximum pore size less than or equal to the diameter of the particles to be removed from the sample, and can be integral with the sorbent or associated with the sorbent. The sorbent is characterized by sufficient selectivity between the matrix interfering agents and analytes of interest to provide retention of the matrix interfering agents while providing elution of the analytes of interest (e.g., a reversed phase or a polar modified reversed phase). Typical devices incorporating these features include luer syringe filters, individual filter cartridges, multiwell plates, pipette tips, or inline columns for multiple or single use. | 2011-10-27 |
20110263041 | COMPOSITION FOR MEASURING THE BINDING AFFINITY BETWEEN NUCLEIC ACID AND TEST SUBSTANCE, AND USE THEREOF - In one embodiment of the present invention, a composition is disclosed for measuring a binding affinity between a nucleic acid and a test substance, which contains an organic fluorescent substance capable of binding to an RNA and which emits fluorescence having an intensity greater while the organic fluorescent substance is liberated from an RNA than while the organic fluorescent substance is bound to an RNA. This enables a highly accurate and easy measurement of a binding affinity between a test substance and a nucleic acid, and allows various substances to be examined as a test substance. | 2011-10-27 |
20110263042 | ASSAY METHOD FOR ANTIBODIES AGAINST CYCLIC CITRULLINATED PEPTIDE - The present invention relates to method for assaying anti-cyclic citrullinated peptide antibodies in a clinical sample, said method comprising contacting said sample with at least one homogeneous reagent comprising at least one specific binder for anti-CCP antibodies, whereby to form a solution or suspension of an anti-CCP-binding partner complex in a homogeneous sample mixture and detecting the presence or level of said anti-CCP-binding partner complex in a homogeneous liquid-phase. The invention also relates to a method for the assessment of the existence of; risk of; potential for; or propensity to RA in a subject. | 2011-10-27 |
20110263043 | Scanning Analyzer for Single Molecule Detection and Methods of Use - The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples. | 2011-10-27 |
20110263044 | DEVICE AND METHOD FOR THE AUTOMATIC DETECTION OF BIOLOGICAL PARTICLES - An apparatus and a method for automatic detection of particles, in particular, biological particles such as micro-organisms. The apparatus has a device for binding the particles to separating particles which can be bound selectively to the particles. The apparatus further includes a separating device for extraction of the separating particles with bound particles from a collecting fluid, and a detection unit for detecting a number and/or concentration of the particles separated in this manner. The device for binding the particles to the separating particles includes a collecting device for collecting a collecting fluid including the separating particles and the particles that are provided by a particle-fluid mixture. | 2011-10-27 |
20110263045 | Method of Detection of Nucleic Acids With a Specific Sequence Composition - This invention is a novel method for detecting and localizing specific nucleic acid sequences in a sample with a high degree of sensitivity and specificity. The method and novel compositions used in the method involve the use of Probe Nucleic Acids, the production of nucleic acid binding regions and the use of nucleic acid Target Binding Assemblies to detect and localize specific Target Nucleic Acids. The detection and localization of the Target Nucleic Acid is accomplished even in the presence of nucleic acids which have similar sequences. The method provides for a high degree of amplification of the signal produced by each specific binding event. In particular, methods and compositions are presented for the detection of HIV and HPV nucleic acid in samples. These methods and compositions find use in diagnosis of disease, genetic monitoring, forensics, and analysis of nucleic acid mixtures. Some of the novel compositions used in the detection method are useful in preventing or treating pathogenic conditions. | 2011-10-27 |
20110263046 | Methods of identification of novel ligands for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (NR1F3) activity - The invention relates to modulators for the orphan nuclear receptor RORgamma and methods for identification and screening of novel modulators for RORgamma activity as well as methods for treating RORgamma mediated diseases with novel RORgamma modulators identified by such methods. | 2011-10-27 |
20110263047 | PEPTIDE TAG AND USES THEREOF - The present invention provides a novel peptide tag, uses of the same and methods and systems for the purification of proteins. In particular, the invention provides the use of a beta-lactam (β-lactam) binding protein or fragment, analogue, homologue, variant or derivative thereof, as a tag or label. | 2011-10-27 |
20110263048 | INSOLUBLE CARRIER FOR USE IN ANTI-PHOSPHOLIPID ANTIBODY MEASUREMENT REAGENT, ANTI-PHOSPHOLIPID ANTIBODY MEASUREMENT REAGENT, AND METHOD FOR MEASURING ANTI-PHOSPHOLIPID ANTIBODY - The present invention has an object to provide an insoluble carrier for an antiphospholipid antibody detection reagent having a high reactivity. The present invention also has an object to provide an antiphospholipid antibody detection reagent, and a method of detecting an antiphospholipid antibody. The present invention directs to an insoluble carrier for an antiphospholipid antibody detection reagent, having a zeta potential of lower than −45 mV in the case that the insoluble carrier is suspended in a 20 mmol/L aqueous sodium phosphate solution with a pH of 7.4 so that the resulting suspension has a solids concentration of 0.1%. | 2011-10-27 |
20110263049 | WAFER EDGE INSPECTION - Wafer edge inspection approaches are disclosed wherein an imaging device captures at least one image of an edge of a wafer. The at least one image can be analyzed in order to identify an edge bead removal line. An illumination system having a diffuser can further be used in capturing images. | 2011-10-27 |
20110263050 | LOW POWER RF TUNING USING OPTICAL AND NON-REFLECTED POWER METHODS - Aspects of the present invention include methods for controlling a plasma in a substrate processing system. One embodiment provides controlling a first set of wavelength intensities of reflected electromagnetic radiation reflected from the plasma within a chamber before processing a first set of one or more substrates, associating the first set of wavelength intensities of reflected electromagnetic radiation to an RF power within the processing system, adjusting a matching circuit based on the first set of wavelength intensities of reflected electromagnetic radiation, processing the first set of one or more substrates in the substrate processing system, controlling a second set of wavelength intensities of reflected electromagnetic radiation reflected from the plasma within the chamber, and associating the second set of wavelength intensities of reflected electromagnetic radiation to the RF power within the processing system. | 2011-10-27 |
20110263051 | INTERLEAF FOR LEADFRAME IDENTIFICATION - A method of making an IC device includes providing a stack of leadframe sheets each including a plurality of leadframes and an interleaf member interposed between adjacent ones of the leadframe sheets. The interleaf members include indicia that identifies the leadframes sheets. The stack of leadframe sheets is loaded onto an assembly machine. A first interleaf member is removed from the first leadframe sheet. The first leadframe sheet is transferred onto a mounting surface of the assembly machine. Semiconductor die are attached to leadframes on the first leadframe sheet. The method can include reading the indicia from the first interleaf member to determine a part number and lead finish for the first leadframe sheet, verifying the part number for the first leadframe sheet by comparing to a build list, and transferring the first leadframe sheet onto a mounting surface of the assembly machine only if the part number is verified. | 2011-10-27 |
20110263052 | METHOD OF REMOVING CONTAMINATIONS - A method of removing contaminations includes providing a wafer, performing an inspection or a measuring step to the wafer, and performing a baking step to re-vaporize and remove contaminations from the wafer after the inspection or measuring step. | 2011-10-27 |
20110263053 | METHOD FOR MANUFACTURING PIXEL STRUCTURE - A pixel structure including a scan line, a data line, an active device, a shielding electrode, and a pixel electrode is provided on a substrate. The data line includes an upper conductive wire and a bottom conductive wire. The upper conductive wire is disposed over and across the scan line. The bottom conductive wire is electrically connected to the upper conductive wire. The active device is electrically connected to the scan line and the upper conductive wire. The shielding electrode is disposed over the bottom conductive wire. The pixel electrode disposed over the shielding electrode is electrically connected to the active device. In addition, parts of the pixel electrode and parts of the shielding electrode form a storage capacitor. | 2011-10-27 |
20110263054 | BOND PAD ISOLATION AND CURRENT CONFINEMENT IN AN LED USING ION IMPLANTATION - An improved method of creating LEDs is disclosed. Rather than using a dielectric coating to separate the bond pads from the top surface of the LED, this region of the LED is implanted with ions to increase its resistivity to minimize current flow therethrough. In another embodiment, a plurality of LEDs are produced on a single substrate by implanting ions in the regions between the LEDs and then etching a trench, where the trench is narrower than the implanted regions and positioned within these regions. This results in a trench where both sides have current confinement capabilities to reduce leakage. | 2011-10-27 |
20110263055 | IN-PLANE SWITCHING MODE LIQUID CRYSTAL DISPLAY DEVICE - An in-plane switching mode liquid crystal display device includes first and second substrates facing each other, a gate line and a data line arranged on the first substrate crossing each other and defining a pixel region, a switching device at a crossing of the gate line and the data line, a common electrode and a pixel electrode alternately disposed in the pixel region, at least one of the common electrode and the pixel electrode including a multi-layer having a conductor layer and a reflectance reducing layer, and a liquid crystal layer formed between the first and second substrates. | 2011-10-27 |
20110263056 | Method of manufacturing a laser diode with improved light-emitting characteristics - The method of the invention is intended for manufacturing a laser diode with improved light-emitting characteristics. The method consists of providing certain components of a laser diode such as a wide-aperture lasing medium that has an active emitting layer with a first end and a second end, a DPH-mode reorganizer that contains a core and a plurality of nanogrooves made in the core and arranged in a pattern that accomplishes a given function and locally changes the refractive index of the core. The method further includes the steps of forming a semitransparent mirror on the second end of the active lasing medium and aligning the first end of the active emitting layer with the core of the DPH-mode reorganizer, thus forming a resonator of the laser diode. In the resonator, the light applied from the laser-active medium bounces back and forth between the DPH-mode reorganizer and the partially reflecting mirror, thereby enhancing stimulated emission. | 2011-10-27 |