43rd week of 2013 patent applcation highlights part 46 |
Patent application number | Title | Published |
20130280704 | ENHANCED DETECTION OF NON-SOMATIC CIRCULATING NUCLEIC ACIDS - Methods, equipment and software for the detection of abnormal nucleic acid or fetal nucleic acid sequences circulating in the subject's blood or other body fluids. A scan of a subject's circulating nucleic acid (CNA) is compared to the CNA Data On Normal Healthy Population or to a scan of the subject's own Somatic Nucleic Acid (SNA). Abnormal peaks are identified by subtracting out the “normal” or somatic peaks. The resultant anomalous peaks are compared to anomalous CNA data to identify the abnormalities, or the anomalous peaks of the subject's CNA are isolated, amplified, and sequenced or probed to determine the nature of the anomaly. | 2013-10-24 |
20130280705 | METHODS AND COMPOSITIONS FOR ASSESSMENT OF PULMONARY FUNCTION AND DISORDERS - The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer, and the suitability of a subject for an intervention in respect of lung cancer. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided. | 2013-10-24 |
20130280706 | Compositions and Methods for Quantifying a Nucleic Acid Sequence in a Sample - The present invention features compositions and methods for quantifying detection of a target oligonucleotide in a sample in real time. These methods are compatible with target oligonucleotides amplified using a NEAR reaction. | 2013-10-24 |
20130280707 | TOP2A INHIBITION BY TEMOZOLOMIDE AND ITS PREDICTIVE VALUE OF GBM PATIENTS SURVIVAL - The present invention provides a TOP2A inhibition by temozolomide useful for predicting glioblastoma patient's survival. Glioblastoma (GBM) is the most common, malignant primary adult brain tumor. The conventional treatments for GBM, include surgery, radiation, and chemotherapy which have only modestly improved patient survival. The patients with GBM expressing higher TOP2A transcript levels had better prognosis. More interestingly, the present invention reports that temozolomide is an inhibitor of TOP2A activity in vitro. The present invention further shows that siRNA knock down of TOP2A rendered a glioma cell line resistant to temozolomide chemotherapy. Thus it is demonstrated for the first time that temozolomide is a TOP2A inhibitor and establishes that TOP2A transcript levels determines the chemosensitivity of glioblastoma to temozolomide therapy thus explaining the very high levels of TOP2A transcript being a good prognostic indicator in GBM patients receiving temozolomide chemotherapy. | 2013-10-24 |
20130280708 | COMPOSITIONS AND METHODS FOR DETECTION OF CANDIDA SPECIES - The invention features compositions and methods for the detection of | 2013-10-24 |
20130280709 | DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample. | 2013-10-24 |
20130280710 | Fluidically Integrated Rotary Bead Beader - A system for at least one of homogenization and lysis of a sample includes one or more walls forming an enclosed chamber having an inlet and a plurality of fluidic connections. A first fluidic network is coupled to at least one of the plurality of fluidic connections and a second fluidic network is coupled to at least one of the plurality of fluidic connections. The system further includes a rotary element within the chamber, and an actuator configured to rotate the rotary element. The first fluidic network is configured to introduce at least a sample into the chamber from at least one first reservoir. The second fluidic network is configured to expel at least the sample from the chamber to at least one second reservoir. The rotary element is rotated by the actuator about an axis extending along a length of the rotary element. | 2013-10-24 |
20130280711 | Probe, and Polymorphism Detection Method Using the Same - The present invention provides a probe for detecting a V600 polymorphism in the BRAF gene, which is (P1) a fluorescently labeled oligonucleotide which has an identity of at least 80% to a base sequence having a length of 10 to 50 bases including the 228th to the 237th bases of the base sequence indicated in SEQ ID NO:1, wherein the base corresponding to the 237th base is cytosine labeled with a fluorescent dye, the oligonucleotide recognizing a polymorphism in at least one of the 228th to the 230th bases of the base sequence indicated in SEQ ID NO:1 (with the proviso that the oligonucleotide is not the one indicated in SEQ ID NO:7 or 19). | 2013-10-24 |
20130280712 | Method of Detecting Nucleic Acid Targets Using a Statistical Classifier - A method of detecting a target nucleic acid in a test sample utilizes a learning statistical classifier system to build a general linear classifier based on an amplification-dependent parameter for the target and the control nucleic acids, in order to classify the test sample as containing or not containing the target nucleic acid. | 2013-10-24 |
20130280713 | POLYNUCLEOTIDE AND USE THEREOF - A first polynucleotide including at least two complementary regions that are complementary to a target nucleic acid and have a reverse configuration, a second polynucleotide complementary to the first polynucleotide, and uses thereof, are provided. | 2013-10-24 |
20130280714 | RAPID SALMONELLA SEROTYPING ASSAY - Processes for the serotype specific detection and identification of one or more | 2013-10-24 |
20130280715 | Methods, Systems and Compositions for Nucleic Acid Analysis Using Back-Scattering Interferometry - Disclosed are methods, systems, and apparatuses for the measurement of hybridization of nucleic acid polymers or binding other biological molecular species such as proteins, enzymes, receptors, and antibodies to binding partners, by backscattering interferometry (BSI). | 2013-10-24 |
20130280716 | Ratio of apoa2 to HDLc or Equivalents thereof, Risk Markers for Cardiovascular Disease - The present disclosure provides methods and markers for characterizing a subject's, particularly a human subject's, risk of having cardiovascular disease. The present disclosure also provides methods of characterizing a subject's risk of developing cardiovascular disease. In another embodiment, the present disclosure provides methods for characterizing a subject's risk of experiencing a complication of cardiovascular disease or major adverse cardiac event within 3 months, 6 months, 1 year, 3 years, 5 years, or 10 years. In another embodiment, the present disclosure provides a method for determining whether a subject presenting with chest pain is at risk near term of experiencing a heart attack or other major adverse cardiac event. The present methods are especially useful for identifying those subjects who are in need of highly aggressive CVD therapies as well as those subjects who require no therapies targeted at inhibiting or preventing CVD or complications of CVD. | 2013-10-24 |
20130280717 | METHOD TO DETERMINE EMBRYO AND OOCYTE QUALITY BASED ON CERAMIDASE - The present invention relates to a method of predicting the likelihood of embryo or oocyte survival. This method involves providing a sample of an embryo, an oocyte, or surrounding liquid or cells, and screening the sample for ceramidase expression or activity. The ceramidase expression or activity obtained through said screening is then correlated to a prediction of the likelihood of embryo or oocyte survival. Also disclosed is a kit. | 2013-10-24 |
20130280718 | Methods and Compositions for Dual Extraction of Protein and Nucleic Acid - The present invention provides a method of isolating nucleic acid and protein from the same biological sample, comprising, in the following order: a) disrupting the biological sample; b) contacting the disrupted biological sample of (a) with a protein lysis buffer that lacks any component that denatures or reduces protein to produce a first lysate; c) centrifuging the first lysate of (b) to produce a first supernatant containing protein and a pellet containing nucleic acid; d) removing the first supernatant of (c), thereby isolating protein from the biological sample; e) contacting the pellet of (d) with nucleic acid lysis buffer to produce a second lysate; f) centrifuging the second lysate of (e) to produce a second supernatant containing nucleic acid; and g) removing the second supernatant of (f), thereby isolating nucleic acid from the same biological sample. | 2013-10-24 |
20130280719 | METHOD OF DERIVING PROGENITOR CELL LINE - We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew. Preferably, the method selects against somatic cells based on their inability to self-renew. Preferably, the progenitor cell line is derived or established in the absence of co-culture, preferably in the absence of feeder cells, which preferably selects against embryonic stem cells. Optionally, the method comprises (d) deriving a differentiated cell from the progenitor cell line. | 2013-10-24 |
20130280720 | TISSUE BIOMARKERS FOR INDICATION OF PROGRESSION FROM BARRETT'S ESOPHAGUS TO ESOPHAGEAL ADENOCARCINOMA - A method of diagnosing progression from Barrett's esophagus toward esophageal dysplasia can include: obtaining miRNA from a test subject having Barrett's esophagus; assaying for miRNA biomarker selected from one or more of miR-15b or miR-486-5p; and determining whether one or more of miR-15b or miR-486-5p provide an indication of progression toward esophageal dysplasia in the test subject. The method can include determining an amount of one or more of miR-15b or miR-486-5p. The method can include determining a modulation in amount of one or more of miR-15b or miR-486-5p. The method can include comparing the one or more of miR-15b or miR-486-5p with a positive control or a negative control. | 2013-10-24 |
20130280721 | METHOD FOR IDENTIFYING OLFACTORY RECEPTOR INCLUDED IN ONE OLFACTORY CELL - The present invention provides a novel method for identifying an olfactory receptor included in one olfactory cell. In the present invention, amplified is the cDNA derived from the mRNA of the one olfactory cell by a PCR method using a forward primer represented by SEQ ID: 01 and a reverse primer represented by SEQ ID: 02. Subsequently, determined is whether or not a gene sequence of the amplified cDNA is identical to one gene sequence included in gene sequences coding for olfactory receptors included in the mouse olfactory receptor group A. Finally, determined is that the olfactory receptor included in the one olfactory cell is the olfactory receptor corresponding to the one gene sequence which is identical to the gene sequence of the cDNA in the previous step, if the gene sequence of the cDNA is identical to the one gene sequence in the previous step. | 2013-10-24 |
20130280722 | METHOD FOR IDENTIFYING OLFACTORY RECEPTOR INCLUDED IN ONE OLFACTORY CELL - The present invention provides a novel method for identifying an olfactory receptor included in one olfactory cell. In the present invention, amplified is the cDNA derived from the mRNA of the one olfactory cell by a PCR method using a forward primer represented by SEQ ID: 01 and a reverse primer represented by SEQ ID: 02. Subsequently, determined is whether or not a gene sequence of the amplified cDNA is identical to one gene sequence included in gene sequences coding for olfactory receptors included in the mouse olfactory receptor group A. Finally, determined is that the olfactory receptor included in the one olfactory cell is the olfactory receptor corresponding to the one gene sequence which is identical to the gene sequence of the cDNA in the previous step, if the gene sequence of the cDNA is identical to the one gene sequence in the previous step. | 2013-10-24 |
20130280723 | METHOD FOR IDENTIFYING OLFACTORY RECEPTOR INCLUDED IN ONE OLFACTORY CELL - The present invention provides a novel method for identifying an olfactory receptor included in one olfactory cell. In the present invention, amplified is the cDNA derived from the mRNA of the one olfactory cell by a PCR method using a forward primer represented by SEQ ID: 01 and a reverse primer represented by SEQ ID: 02. Subsequently, determined is whether or not a gene sequence of the amplified cDNA is identical to one gene sequence included in gene sequences coding for olfactory receptors included in the mouse olfactory receptor group A. Finally, determined is that the olfactory receptor included in the one olfactory cell is the olfactory receptor corresponding to the one gene sequence which is identical to the gene sequence of the cDNA in the previous step, if the gene sequence of the cDNA is identical to the one gene sequence in the previous step. | 2013-10-24 |
20130280724 | METHODS FOR DIAGNOSING IMPENDING DIARRHEA - The invention provides methods for diagnosing impending diarrhea in an asymptomatic animal. The methods comprise obtaining a fecal sample from the animal; identifying one or more microorganisms in the fecal sample; and diagnosing impending diarrhea in the animal based on the presence or absence of one or more of the microorganisms. | 2013-10-24 |
20130280725 | FLUIDIC DEVICES FOR BIOSPECIMEN PRESERVATION - The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant. | 2013-10-24 |
20130280726 | COMPOSITE LIQUID CELLS - A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in a carrier-liquid conduit comprising a stabilisation feature and (b) proximate to the stabilisation feature, the encapsulating liquid being immiscible with the carrier liquid, so that the discharged encapsulating liquid does not mix with the carrier liquid, floats on top of the carrier liquid, and is immobilised by the stabilisation feature; drawing a sample liquid from a sample-liquid input; and discharging the drawn sample liquid, the sample liquid being immiscible with the encapsulating liquid and with the carrier liquid, so that the sample liquid does not mix with the encapsulating liquid or with the carrier liquid. | 2013-10-24 |
20130280727 | METHODS FOR DETECTING NUCLEIC ACIDS INDICATIVE OF CANCER - The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer. | 2013-10-24 |
20130280728 | METHOD AND KIT FOR PROCESSING WAX-EMBEDDED BIOLOGICAL SAMPLES - The present invention relates to a method for processing a wax-embedded biological sample, the use of poly(organosiloxane)s for liquefying the embedding medium of a wax-embedded biological sample and a kit for processing a wax-embedded biological sample. | 2013-10-24 |
20130280729 | CANCERATION INFORMATION PROVIDING METHOD AND CANCERATION INFORMATION PROVIDING DEVICE - Provided is a canceration information providing method capable of presenting the information related to canceration of the cells with high reliability. A cell in which the amount of DNA is greater than or equal to the amount of DNA of the normal cell in the S period is extracted from a cell group of V | 2013-10-24 |
20130280730 | CANCERATION INFORMATION PROVIDING METHOD AND CANCERATION INFORMATION PROVIDING DEVICE - Provided is a canceration information providing method capable of presenting information related to canceration of cells with high reliability. A cell in which an amount of DNA is greater than or equal to an amount of DNA of a normal cell in a S period is extracted from a cell group of V | 2013-10-24 |
20130280731 | RATIONAL ENZYME MINING - A method for rational mining for induced enzymes in microbial communities is described. The method is characterized in that a community of microorganisms is provided and that the microbial populations of the community are cultivated in a container under conditions of choice, where the microorganisms are given a defined culturing medium, to eliminate matter deriving from the natural habitat and to allow the microbial community to reach a metabolic steady-state. The method is further characterized in that at least one fraction of microorganisms is taken from the container and transferred into at least two separate containers, where at least one of the fractions of microorganisms is provided with a defined medium which includes an inducing substance and/or a substance against which enzyme/enzymes is/are desired, to induce regulation of expression of the desired enzyme/enzymes, and at least one fraction is provided with a defined medium without said inducing substance and without said substance against which enzyme/enzymes is/are desired, for the purpose of comparison, and the fractions are maintained and/or cultivated. Samples of the two fractions are then withdrawn and analyzed for identification of the induced enzyme/enzymes. | 2013-10-24 |
20130280732 | DIAGNOSTIC DRUG AND DIAGNOSTIC METHOD FOR ALZHEIMER'S DISEASE - The present invention provides an agent for determining Alzheimer's disease, comprising an anti-S38AA antibody, a method of determining Alzheimer's disease in a test animal, comprising detecting an S38AA fragment in a sample collected from said animal, and a method of screening for a substance that treats or prevents Alzheimer's disease, comprising contacting a test substance with a cell permitting measurement of production of a S38AA fragment, measuring the production amount of the S38AA fragment in the cell, and comparing the production amount with that of the S38AA fragment in a control cell free of contact with the test substance, and selecting a test substance that down-regulates the production amount of the S38AA fragment as a substance capable of treating or preventing Alzheimer's disease, based on the comparison results. | 2013-10-24 |
20130280733 | Biomarkers for the Diagnosis of ALS - Methods for determining the onset of ALS in a subject are provided. One method includes analyzing a sample obtained from the subject for the presence or amount of one or more biomarkers indicative of ALS. In a preferred embodiment, the biomarkers are one or more of the following: C-reactive protein (CRP), cystatin c, plasminogen, complement C3, CysGly-transthyretin, and phosphorylated neurofilament heavy chain (pNFH). The sample is typically cerebral spinal fluid (CSF). The levels or concentrations of the biomarkers can be used to determine the onset of ALS, monitor the progression of ALS, or monitor the progression of a treatment for ALS. | 2013-10-24 |
20130280734 | BIOASSAY METHOD FOR DETECTING PHYSIOLOGICALLY ACTIVE SUBSTANCE - Provided are a procedurally simple and safe method and kit for measuring the concentration in a biological sample of a physiologically active substance which binds to a receptor that causes a change in intracellular cAMP concentration. By providing a composition including genetically-modified cells which show co-expression of a receptor that causes a change in intracellular cAMP concentration, a cyclic nucleotide-responsive calcium channel, and aequorin luminescent protein, it is possible to measure how much of a physiologically active substance which binds to said receptor is included in a biological sample. | 2013-10-24 |
20130280735 | Gene Expression Control DNA Element and Associated Protein - Through screening of an expression library, a cDNA sequence has been identified that encodes a protein that interacts with human CD33, the DNA being highly homologous to a portion of the human dystrophin gene. A region of that cDNA has been identified as an important regulatory element in controlling expression, both transcription and translation, of the DNA with which it is associated. This DNA sequence element may be used as a regulatory cassette in conjunction with any suitable gene, to modify gene expression. The putative controlling DNA sequence element contains a minimum of 137 base pairs (FIG. | 2013-10-24 |
20130280736 | REAGENTS AND METHODS FOR DIAGNOSING CONDITIONS ASSOCIATED WITH HYDROXYLATED HIF 1-ALPHA - The invention relates to reagents and methods for detecting, diagnosing and screening for conditions associated with hydroxylated hypoxia inducible factor 1-α (HIF-1α). The invention also relates to novel monoclonal antibodies specific for hydroxylated HIF-1α, or binding fragments thereof, and related nucleic acids, vectors, cells and compositions, as well as methods of using the antibodies in methods of the invention. | 2013-10-24 |
20130280737 | CHEMILUMINESCENCE COMPACT IMAGING SCANNER - Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner. | 2013-10-24 |
20130280738 | DIAGNOSTICS FOR MEMBRANOUS NEPHROPATHY - The invention provides immunoassays for detecting serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R) and uses thereof for diagnosis and prognosis evaluation of idiopathic membranous nephropathy (MN). | 2013-10-24 |
20130280739 | DETERMINATION OF THE EFFICACY OF AN ANTI-MYCOBACTERIAL VACCINATION - The invention relates to methods and reagents for determining efficacy of vaccine, particularly of a tuberculosis vaccine. | 2013-10-24 |
20130280740 | Methods for Detecting Symmetrical Dimethylarginine - Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases. | 2013-10-24 |
20130280741 | METHOD AND SYSTEM OF DETECTING DIOXIN-LIKE COMPOUNDS - The invention relates to a method or a cell free system of detecting dioxin-like compounds in a test sample using a whole cell lysate derived from a cell transfected to express a fusion protein comprising an AHR fused to a reporter peptide. The method in combination with bioluminescence resonance energy transfer (BRET) technique is also provided so as to improve the sensitivity. | 2013-10-24 |
20130280742 | QUANTIFICATION AND CHARACTERIZATION OF ALLERGENS - Embodiments of the invention include methods of determining the allergen content of a composition. Embodiments of the invention may include providing a composition comprising an allergen; at least partially purifying the allergen from the composition to form an extract; and determining the amount of allergen in the extract using liquid chromatography with ultraviolet and mass spectrometric detection. | 2013-10-24 |
20130280743 | DETECTION OF SALIVA PROTEINS MODULATED SECONDARY TO DUCTAL CARCINOMA IN SITU OF THE BREAST - A method of differentiating among the presence of ductal carcinoma in situ in the breast, benign fibroadenoma of the breast, and non-cancerous breast tissue in a subject is disclosed. The method comprises: measuring the concentration of at least one protein biomarker selected from a group of forty-nine differentially expressed proteins in the saliva of persons with DCIS, or benign fibroadenoma, or in persons who are cancer-free. The resulting test data is compared to a reference panel. From the comparison the presence in the subject of either ductal carcinoma in situ of the breast, or benign fibroadenoma of the breast is determined. | 2013-10-24 |
20130280744 | ENVIRONMENTAL BIOLOGICAL ALLERGEN MEASUREMENT METHOD, AND SIMPLE KIT FOR MEASURING BIOLOGICAL ALLERGEN - It is an object of this invention to provide an environmental biological allergen measurement method capable of simple and low-cost measurement of the amount of an environmental biological allergen without using anti-allergen antibodies or a special substrate, and to provide a simple biological allergen quantification kit for carrying out the method. The object can be achieved by a biological allergen measurement method characterized in that the amount of an environmental biological allergen is measured by bringing a test substance into contact with a water-soluble gel or aqueous solution containing a substrate of the protease of the environmental biological allergen, and by quantifying the physical change of the water-soluble gel or the aqueous solution caused by the effect of the protease contained in the test substance on the substrate. | 2013-10-24 |
20130280745 | HIGH-THROUGHPUT, SENSITIVE DETECTION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE - Provided herein are methods for determining an amount of glucose-6-phosphate dehydrogenase (“G6PDH”) in a biological sample. Also provided herein are methods for detecting G6PDH deficiency, as well as diagnosing G6PDH-associated disorders, such as acute hemolytic anemia and pre-eclampsia. | 2013-10-24 |
20130280746 | PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glyccrolipid (including glyccrophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells. | 2013-10-24 |
20130280747 | CELL CULTURE APPARATUS - The invention provides a unique cell culture chamber, as well as systems for culturing and analyzing cells, methods of using the chamber, and techniques for culturing and analyzing cells. The invention also provides an apparatus for distributing cells across a substrate, comprising a chamber comprised of at least one polydimethylsiloxane (PDMS) surface, where the chamber comprises one or more wells, and each well can contain a volume of a suspension of cells in culture, and where the chamber, when placed over a substrate, provides a more uniform dispersement of cells on the substrate than when the cells are deposited on a substrate without said chamber. | 2013-10-24 |
20130280748 | METHOD AND MICROPLATE READER FOR INVESTIGATING BIOLOGICAL CELLS OR CELL CULTURES - A method for investigating biological cells or cell cultures in a microplate reader receives at least one microplate with wells containing biological cells or cell cultures by a receiving device; positions the wells with respect to measuring devices of the microplate reader and detects integral measurement signals by at least one of the measuring devices. The biological cells or cell cultures in the specific wells of the microplate(s) are transilluminated by an illumination source of the microplate reader and imaged by an imaging camera. Each of the detected integral signals is compared with the image of the biological cells or cell cultures in the corresponding wells of the microplate(s) by a processor and is related to the imaged number, adherence, confluence or morphology of these biological cells or cell cultures. | 2013-10-24 |
20130280749 | NOVEL BIOSENSORS AND THEIR USE - A FRET donor-acceptor pair for use as a biosensor, comprising at least two fluorescence proteins, wherein at least one fluorescence protein is stable with respect to a parameter to be detected by the biosensor and at least one fluorescence protein is unstable with respect to the parameter to be detected by the biosensor. | 2013-10-24 |
20130280750 | MAINTENANCE OF DIFFERENTIATED CELLS WITH LAMININS - The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phenotype of the differentiated cell. | 2013-10-24 |
20130280751 | METHOD AND PROBE FOR MONITORING OXYGEN STATUS IN LIVE MAMMALIAN CELLS - The invention is based on the use of photoluminescent probes for intracellular sensing of oxygen, especially assaying intracellular oxygen concentration. The photoluminescent probe comprises a suspension of polymeric particles having an average diameter in the 20 nm to 100 nm range, formed from an amphiphilic cationic co-polymer which is oriented in the formed particle to provide a hydrophobic core and a hydrophilic shell. The probe includes a hydrophobic oxygen-sensitive photoluminescent dye such as Pt-tetrakis(pentafluorophenyl)porphine, PtPFPP embedded in the hydrophobic core of the particle, and the co-polymer includes quaternary ammonium groups which provide hydrophilic and cationic character to the particle shell. The photoluminescent probe, which in use is provided in the form of an aqueous suspension of probe, is incubated with live mammalian cells in a suitable growth medium for a period of time to allow the probe particles passively load into the cells. Oxygen can then be sensed by detecting a photoluminescent signal of the photoluminescent probe, which can be correlated with oxygen status, for example oxygen concentration or changes in oxygen concentration/levels, using existing techniques. | 2013-10-24 |
20130280752 | LENS-FREE TOMOGRAPHIC IMAGING DEVICES AND METHODS - A system for three dimensional imaging of an object contained within a sample includes an image sensor, a sample holder configured to hold the sample, the sample holder disposed adjacent to the image sensor, and an illumination source comprising partially coherent light. The illumination source is configured to illuminate the sample through at least one of an aperture, fiber-optic cable, or optical waveguide interposed between the illumination source and the sample holder, wherein the illumination source is configured to illuminate the sample through a plurality of different angles. | 2013-10-24 |
20130280753 | IN VITRO MITOCHONDRIAL FUNCTION TEST (MFT) AND USES THEREOF - The present document describes an in vitro method for determining a level of mitochondrial function from a subject by determining a change in a labeled compound labeling a viable cell or tissue sample isolated from a subject following introduction of a volume of a solution over said viable cell or tissue sample. The comparison of the change to a normal reference is indicative of mitochondrial function in the subject. | 2013-10-24 |
20130280754 | 3D Cell Viability Assay - Cells are grown in 3D culture and topological features obtained by photomicrography are correlated to cell viability and cell cell interactions. | 2013-10-24 |
20130280755 | THERAPEUTIC METHODS FOR SOLID DELIVERY - A fluid-delivery device includes an array of needles. The needle can deposit a hollow and/or porous tube into a tissue of a subject, and the porous tube can contain one or more fluid agents. The hollow and/or porous tube can control the rate at which the agents diffuse into the tissue. The device can simultaneously deliver a plurality of porous tubes along parallel axes in a tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue; based on the evaluation, candidate agents or subjects can be selected or deselected for clinical trials or therapy. | 2013-10-24 |
20130280756 | CULTURE MEDIUM FOR MICROORGANISMS INCLUDING PARA-AMINOBENZOIC ACID AS A SELECTIVE AGENT - The field of the invention is the analysis of target microorganisms in a complex sample. The present invention more particularly relates to a culture medium for the detection of at least one target microorganism including: at least one natural or synthetic fermentation or enzymatic activity substrate, and at least one selective agent, which inhibits non-target microorganisms, constituted by para-amino benzoic acid, one of its derivatives or one of their salts, at a concentration of between 0.05 and 1 g/L. | 2013-10-24 |
20130280757 | ALGAE BIOREACTOR, SYSTEM AND PROCESS - The present disclosure provides an algae bioreactor and process. The algae bioreactor includes a container with an inlet and an outlet. An algae suspension present in the container interior moves from an inlet to an outlet along a flowpath. A light assembly, a liftwall, and a gas conduit are located in the container interior. The gas conduit extends along a length of the container and emits gas bubbles into the algae suspension. A diffuser is located on a bottom wall of the container, The flowpath, the liftwall, the gas conduit, and the diffuser produce an active flow of the algae from the container inlet to the container outlet. The container may be a deep-vessel container. | 2013-10-24 |
20130280758 | FUSION POLYPEPTIDES CAPABLE OF ACTIVATING RECEPTORS - A fusion polypeptide comprising (A) | 2013-10-24 |
20130280759 | NOVEL ANTIGEN ASSOCIATED WITH THE NEOVASCULATURE OF TUMOUR METASTASES - The invention relates to a binding member that binds the Extra Domain-A (ED-A) isoform of fibronectin for the treatment of tumour metastases. | 2013-10-24 |
20130280760 | HIGH PURITY LIPOPETIDES - The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of | 2013-10-24 |
20130280761 | ASPERGILLUS CONTAINING BETA-GLUCOSIDASE, BETA-GLUCOSIDASES AND NUCLEIC ACIDS ENCODING THE SAME - A novel microorganism is provided named | 2013-10-24 |
20130280762 | METHODS FOR PRODUCING AND USING DENSIFIED BIOMASS PRODUCTS CONTAINING PRETREATED BIOMASS FIBERS - A process is provided comprising subjecting a quantity of plant biomass fibers to a pretreatment to cause at least a portion of lignin contained within each fiber to move to an outer surface of said fiber, wherein a quantity of pretreated tacky plant biomass fibers is produced; and densifying the quantity of pretreated tacky plant biomass fibers to produce one or more densified biomass particulates, wherein said biomass fibers are densified without using added binder. | 2013-10-24 |
20130280763 | ARCHEASE AS RNA LIGASE COMPLEX MEMBER - The present invention relates to the use of Archease proteins as RNA ligase enhancer, methods of ligating RNA molecules, kits for these methods and uses and transgenic cells. | 2013-10-24 |
20130280764 | METHOD OF IMPROVING THE ACTIVITY OF CELLULASE ENZYME MIXTURES IN THE SACCHARIFICATION (LIGNO)CELLULOSIC MATERIAL - The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: | 2013-10-24 |
20130280765 | Method for Transforming Iota-Carrageenan Into Alpha-Carrageenan by Means of a New Class of 4S-Iota-Carrageenan Sulfatase - A method for transforming iota-carrageenan into alpha-carrageenan by a new class of 4S-iota-carrageenan sulfatase. The invention also relates to carrageenans obtained by the conversion method. The invention can be especially applied to the agro-food, pharmaceutical and cosmetic industries. | 2013-10-24 |
20130280766 | HYBRID POLYKETIDE SYNTHASES - The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin. | 2013-10-24 |
20130280767 | HOLLOW FIBER MEMBRANE MODULE AND METHOD FOR PRODUCING CHEMICAL SUBSTANCE - A hollow fiber membrane module includes a housing, a hollow fiber membrane sealed in the housing and a sealing agent in a space between the hollow fiber membrane and the housing, wherein 1) the hollow fiber membrane is made of a polysulfone based resin; 2) a membrane surface average pore diameter is 5 nm or more and 500 nm or less; 3) a pure water permeability coefficient under 50 kPa at 25° C. is 0.05 m | 2013-10-24 |
20130280768 | PROCESS FOR PREPARING AN ENANTIOMERICALLY ENRICHED, DEUTERATED SECONDARY ALCOHOL FROM A CORRESPONDING KETONE WITHOUT REDUCING DEUTERIUM INCORPORATION - The present invention provides a process for the preparation of enantiomerically enriched, deuterated secondary alcohols of Formula 1-A by employing ketoreductases or carbonyl reductases without reducing deuterium incorporation. | 2013-10-24 |
20130280769 | INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY - The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene. | 2013-10-24 |
20130280770 | Transgenic Algae with Enhanced Oil Expression - The present invention provides transgenic algal cells that produce an increased amount of oil, methods of making transgenic algal cells, and methods of obtaining biofuel from the transgenic algal cells. | 2013-10-24 |
20130280771 | METHOD FOR PRODUCING BIODIESEL - The present disclosure is directed to the method for producing the biodiesel comprising steps of providing a biomass having an oil, obtaining a crude mixture of the biomass, and then performing a transesterification in which the crude mixture is used as a reacting material thereof to produce the biodiesel. | 2013-10-24 |
20130280772 | Reagents and Methods for Cyanobacterial Production of Bioplastics and Biomaterials - The present invention provides reagents and methods for biomaterial production from cyanobacteria. | 2013-10-24 |
20130280773 | METHOD FOR PRODUCING CHEMICAL BY CONTINUOUS FERMENTATION - A method of producing a chemical includes a fermentation step that converts a fermentation feedstock, through fermentation by culturing a microorganism or culture cells, into a fermented liquid containing the chemical, and a membrane separation step that collects the chemical, as a filtrate, from the fermented liquid with the use of two or more separation membrane modules, and returning the non-filtered liquid to the fermented liquid, wherein in the membrane separation step, timing of the filtration-stop treatment for each separation membrane module is controlled when an intermittent filtration operation including alternately repeating a filtration treatment and a filtration-stop treatment is performed with plural separation membrane modules. | 2013-10-24 |
20130280774 | DIRECT STARCH TO FERMENTABLE SUGAR AS FEEDSTOCK FOR THE PRODUCTION OF ISOPRENE, ISOPRENOID PRECURSOR MOLECULES, AND/OR ISOPRENOIDS - Provided herein are compositions and methods related to the direct conversion of the starch in a ground or fractionated grain into a fermentable sugar feedstock capable of serving as a carbon source for the industrial production of one or more products by a fermenting organism, such as isoprene, isoprenoid precursor molecules, and/or isoprenoids. Such conversions may be performed at temperatures at or below the initial gelatinization temperature of the starch present in the grain and may utilize one or more isolatable endogenous enzymes present in certain unrefined grains. | 2013-10-24 |
20130280775 | Recombinant N-propanol and Isopropanol Production - The present invention relates to methods of producing n-propanol, isopropanol, and coproducing n-propanol with isopropanol. The present invention also relates to methods for producing propylene, as well as host cells capable of n-propanol and isopropanol production. | 2013-10-24 |
20130280776 | METHODS AND SYSTEMS FOR PRODUCING ETHANOL USING RAW STARCH AND FRACTIONATION - The present invention relates to methods for producing high levels of alcohol during fermentation of plant material, and to the high alcohol beer produced. The method can include fractionating the plant material. The present invention also relates to methods for producing high protein distiller's dried grain from fermentation of plant material, and to the high protein distiller's dried grain produced. The method can include drying a co-product by ring drying, flash drying, or fluid bed drying. The present invention further relates to reduced stack emissions from drying distillation products from the production of ethanol. | 2013-10-24 |
20130280777 | DIGESTER - The present invention relates to a digester ( | 2013-10-24 |
20130280778 | REDUCTION OF CARBON DIOXIDE EMISSION DURING ISOPRENE PRODUCTION BY FERMENTATION - The present invention provides methods for increasing the amount of isoprene produced by cultured cells with only a minimal increase in carbon dioxide emitted, thereby resulting in process having a greater yield of isoprene relative to carbon dioxide. In addition, the present invention provides compositions that include the cultured cells or isoprene produced there from. | 2013-10-24 |
20130280779 | METHOD AND PLANT FOR THE METHANATION OF BIOMASS - A method for the methanation of biomass and the energetic use of the biogas obtained in a plant featuring at least one fermenter operating in a batch process, the fermenter is filled with biomass, a loading opening is closed in an airtight manner, methane-rich biogas produced in a fermentation phase is fed into a first gas storage unit, at least intermittently, during the flushing of the fermenter with flushing air, mixed gas with low methane content is fed into a second gas storage unit, at least intermittently, the loading opening is opened and the fermentation residue is removed from the fermenter. The energetic use of gas stored in the second gas storage unit is carried out such that gas removed from this gas storage unit is mixed with the biogas removed from the first gas storage unit before the mixed gas produced in this way is subsequently used energetically. | 2013-10-24 |
20130280780 | Methods and Compositions for Targeting Heterologous Integral Membrane Proteins to the Cyanobacterial Plasma Membrane - This disclosure pertains to the functional localization of heterologous integral plasma membrane proteins (HIPMPs) lacking cleavable signal sequences into the plasma membrane (PM) of cyanobacterial hosts, e.g., JCC138 ( | 2013-10-24 |
20130280781 | A CONTAMINANT REDUCING AMIDE FUNCTIONALIZED ORDERED MESOPOROUS CARBON CONJUGATE - The present invention provides a series of new and improved compounds/materials as vehicles to delivery degradative enzymes to remove/remedy environmental pollutants. The inventive material comprises a series of amide-functionalized ordered mesoporous carbon (AFOMC), which utilizes chemical conjugation techniques for the tethering of enzymes to the surface of the synthesized AFOMC. The delivery mechanism may be utilized to express a wide variety of toxin-degrading enzymes for removal/remediation of organic pollutants. | 2013-10-24 |
20130280782 | PROTEIN-BASED CONJUGATES AND SELF-ASSEMBLED NANOSTRUCTURES - The present disclosure provides protein-containing compositions, methods and uses thereof. A conjugate comprises a globular protein conjugated with a polymer that preserves the folded and functional structure of a protein. In some embodiments, a fusion protein comprises a globular protein conjugated with an elastin-mimic polymer (EMP). Also disclosed is an assembled solid-state or gel-state nanostructure comprising a plurality of conjugates, wherein each comprises a globular protein conjugated with a polymer that preserving the folded and functional structure of a protein. In certain embodiments, provided compositions and methods further comprise an additive. | 2013-10-24 |
20130280783 | POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD - Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol. | 2013-10-24 |
20130280784 | ESCHERICHIA COLI EXPRESSION SYSTEM FOR PRODUCING MATURE HUMAN TYROSINASE AND A PRODUCING METHOD THEREOF | 2013-10-24 |
20130280785 | METHOD OF PRODUCING AND PURIFYING SOLUBLE RECOMBINANT COQ5 PROTEIN AND SOLUBLE RECOMBINANT COQ5 PROTEIN THEREOF - The present invention relates to a producing and purifying method of soluble recombinant COQ5 protein, which is expressed in soluble form by | 2013-10-24 |
20130280786 | ENZYMES AND USES THEREOF - The present invention relates to novel enzymes and the uses thereof. The invention also relates to methods of producing such enzymes, coding nucleic acid molecules, recombinant cells and methods of transforming biomass from such materials. The invention is particularly suited to degrade biomass and/or to improve biomass degradation, and to produce bioenergy products or recombinant proteins. This invention also relates to various applications of the enzymes in the field of paper industry, textile industry as well as in the chemical and medical fields. | 2013-10-24 |
20130280787 | EXTRACTION OF NUCLEIC ACIDS FROM WAX-EMBEDDED SAMPLES - The present invention relates to a method for extracting nucleic acids from a wax-embedded sample, the use of particular solvents for removing wax from a wax-embedded sample in a method for extracting, isolating and/or purifying nucleic acids from a crosslinked wax-embedded sample as well as to a kit for extracting, isolating and/or purifying nucleic acids from a wax-embedded sample. | 2013-10-24 |
20130280788 | CHROMATOGRAPHY METHOD - The present invention is directed to a continuous affinity chromatography method and to an apparatus to be used in such method. The method allows the use of high operational velocity while maintaining high binding capacities. | 2013-10-24 |
20130280789 | ISOLATION, IDENTIFICATION AND CHARACTERISATION OF STRAINS WITH PROBIOTIC ACTIVITY, FROM FAECES OF INFANTS FED EXCLUSIVELY WITH BREAST MILK - The invention relates to probiotic micro-organisms isolated from feces of children exclusively fed with breast milk. Said microorganisms are used in the food or pharmaceutical industry, especially for use in infant formula milk, due to their probiotic properties which have beneficial effects on the health of those ingesting them. Said microorganisms consist of | 2013-10-24 |
20130280790 | ISOLATION, IDENTIFICATION AND CHARACTERISATION OF STRAINS WITH PROBIOTIC ACTIVITY, FROM FAECES OF INFANTS FED EXCLUSIVELY WITH BREAST MILK - The invention relates to probiotic micro-organisms isolated from faeces of children exclusively fed with breast milk. Said microorganisms are used in the food or pharmaceutical industry, especially for use in infant formula milk, due to their probiotic properties which have beneficial effects on the health of those ingesting them. Said microorganisms consist of | 2013-10-24 |
20130280791 | Method for Making Dehydrated Mycelium Elements and Product Made Thereby - A living hydrated mycelium composite containing at least one of a combination of mycelium and fibers, mycelium and particles, and mycelium, particles and fibers is processed with a nutrient material to promote mycelia tissue growth; thereafter dehydrated to a moisture content of less than 50% by weight to deactivate the further growth of mycelia tissue; and then stored. The stored dehydrated mycelium composite is further processed by rehydrating to reactivate the mycelium and to initiate growth of at least one fruiting body. | 2013-10-24 |
20130280792 | PROCESSING EQUIPMENT FOR ORGANIC WASTE - A facility for complex processing of organic waste. The facility includes a waste preparation module, which includes waste separation, waste mixing and biotunnel. The facility further includes a module for waste pyrolysis and gasification, including a reactor for pyrolysis and partial gasification connected to a gasification reactor. The reactor for pyrolysis and partial gasification and the reactor for gasification contain melts of salts. Further, the reactors are connected with a gas storage tank which is connected with a reactor for power and heat generation. | 2013-10-24 |
20130280793 | CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES - The invention relates to methods for producing lipids such as fatty acid products in recombinant host cells engineered to express a non-native gene encoding a dehydrogenase. The recombinant microorganisms are able to proliferate at a higher rate as compared with microorganisms that do not express a non-native dehydrogenase gene, and cultures of microorganisms that are engineered for lipid production and that express a non-native dehydrogenase produce more lipid than cultures of control microorganisms that do not include a non-native dehydrogenase gene. | 2013-10-24 |
20130280794 | STORAGE-STABLE LIQUID WASHING OR CLEANING AGENT CONTAINING PROTEASE AND CELLULASE - According to the invention, storage stability in terms of cellulolytic activity is to be improved in a liquid washing or cleaning agent which comprises a protease and cellulase. This is achieved by the use of a protease which comprises an amino acid sequence which is at least 80% identical to the amino acid sequence specified in SEQ ID NO. 1 and which has the amino acid glutamic acid (E) or aspartic acid (D) or the amino acid asparagine (N) or glutamine (Q) or the amino acid alanine (A) or glycine (G) or serine (S) at position 99 in the count according to SEQ ID NO. 1. | 2013-10-24 |
20130280795 | SAMPLING AND TESTING DEVICE FOR THE HUMAN OR ANIMAL BODY - A test device comprises first and second indicia portions. The first indicia portion is configured to indicate the presence or absence of at least one medical condition based on identification of at least one biological entity in the biological sample. The second indicia portion is configured to display all or part of a code when the first indicia portion provides an indication of the presence of the medical condition, the code being substantially unique to the test device. The test device is employed in a medication dispensing system. | 2013-10-24 |
20130280796 | POROUS MEMBRANE WAVEGUIDE SENSORS AND SENSING SYSTEMS THEREFROM FOR DETECTING BIOLOGICAL OR CHEMICAL TARGETS - A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size <2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler. | 2013-10-24 |
20130280797 | MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING - A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein. | 2013-10-24 |
20130280798 | DISTANCE MEASUREMENT SYSTEM AND OPTICAL RESOLUTION IMPROVEMENT APPARATUS - A distance measurement system includes: an irradiating means for irradiating two coherent electromagnetic waves having frequencies different from each other to an object under measurement in a partially displacing manner while having a same area; an electromagnetic wave detecting means for detecting electromagnetic waves from at least two or more areas on the object under measurement with a boundary line being interposed therebetween to extend in a direction substantially perpendicular to the displacement direction; a signal generating means for generating a difference signal or a summation signal of respective outputs of the electromagnetic waves detected in the electromagnetic wave detecting means at symmetrical positions with respect to the boundary line; and a measuring means for obtaining a phase difference or intensity difference of the difference signal or summation signal to obtain measurement values. | 2013-10-24 |
20130280799 | METHOD FOR THE EFFECTIVE DELIVERY OF PHOTONIC ENERGY TO CULTURES IN A FLUID MEDIUM - A method of preventing bio-filming during the delivery of photonic energy to a culture or set of organisms in a fluid culture medium, the method including introducing a fluid energy-transfer medium into the fluid culture medium through an interface; and distributing light into the fluid energy-transfer medium as it is introduced into the fluid culture medium. | 2013-10-24 |
20130280800 | Filter Test Strip - A filter test strip to filter and test a specimen in liquid includes a test element and a specimen filter assembly which is located on the test element and includes a filter cotton holding layer, a filter cotton layer and a cotton bonding layer. | 2013-10-24 |
20130280801 | FLOWABLE TISSUE MATRICES - Disclosed herein are flowable tissue matrix compositions comprising small pieces of partially or completely decellularized tissue suspended in a gelatinized tissue or gelatin gel comprising partially or completely decellularized tissue or synthetic gelatin. The flowable tissue matrix compositions can contain factors that promote or enhance native cell migration, proliferation, and/or revascularization after implantation into a subject. Also disclosed are methods of making and using the flowable tissue matrix compositions. The compositions can be implanted into a tissue in need of repair, regeneration, healing, treatment, and/or alteration, and can promote or enhance native cell migration, proliferation, and/or revascularization. | 2013-10-24 |
20130280802 | AGENTS AND METHODS FOR INHIBITING HUMAN PLURIPOTENT STEM CELL GROWTH - The present invention relates to compositions and methods for inhibiting or suppressing undifferentiated or pluripotent stem cell growth and proliferation in a differentiated or differentiating cell population or culture. | 2013-10-24 |
20130280803 | DEFINED CELL CULTURING SURFACES AND METHODS OF USE - In one aspect, there is provided a cell culturing substrate including: | 2013-10-24 |