43rd week of 2014 patent applcation highlights part 44 |
Patent application number | Title | Published |
20140315150 | Laboratory Implant - A method for the production of a dental implant with a post part which can be introduced into a jawbone and with a mounting part assigned thereto, on which a dental prosthetic piece can be mounted, is to allow the dental technician to perform a simple indexing of the mounting part while drawing on current procedural steps. For this purpose, the apical end of the mounting part is shaped in order to adapt the external cross-section of the mounting part to the internal cross-section of the post part. | 2014-10-23 |
20140315151 | IMPLANT STRUCTURE - An object of the present invention is to provide an implant structure assuring that substances accelerating breeding of bacteria are hard to be induced. The implant structure comprises: an artificial tooth root including an artificial tooth root main body having a distal end portion and a proximal end portion and a thread being formed at least on the distal end portion side and an induction portion for inducing a soft tissue provided on an outer periphery of the proximal end portion of the artificial tooth root main body; and a support base having a covering portion at the proximal end portion side of the support base covering the whole surface of the proximal end portion side of the induction portion, wherein the support base is provided with a step portion along its outer periphery from the covering portion toward a distal end side of the support base. | 2014-10-23 |
20140315152 | CUSTOMISED DENTAL ABUTMENT FORMED OF TWO CUSTOMISED PARTS - Disclosed is a dental prosthesis including an implant, a customised abutment, a restoration and an implant screw for securing the customised abutment to the implant, wherein the implant includes a screw bore extending from a first end of the implant for receiving at last a part of the implant screw, the customised abutment includes a through-going bore for receiving at least a part of the implant screw, the screw bore and the through-going bore are coaxially aligned along an implant axis when the implant screw is arranged in the screw and through-going bore, the abutment includes a customised abutment base and a customised abutment top where the customised abutment base and the customised abutment top defines an assembly axis along which they were assembled during manufacturing, where the implant axis is different from the assembly axis. | 2014-10-23 |
20140315153 | FABRICATION OF AN ORTHODONTIC ALIGNER FROM A NEGATIVE MOLD DESIGNED BY A COMPUTATIONAL DEVICE - Provided is a method in which a computational device generates a design of a negative mold of teeth. The negative mold of the teeth is fabricated from the design of the negative mold. An aligner is formed using the fabricated negative mold. Provided also is a negative mold of teeth for fabricating a positive model of the teeth for an aligner. The negative mold comprises a tooth surface, and an identity tracking entity coupled to the tooth surface to provide identification. | 2014-10-23 |
20140315154 | METHOD FOR DIMENSIONAL ADJUSTMENT FOR DENTAL SCAN, DIGITIZED MODEL OR RESTORATION - A method for creating a substantially accurate dental restoration from scanning a negative dental impression of a patient's teeth or a positive dental stone model of the patient's teeth includes applying a compensation rate to compensate for the shrunk or enlarged scan of the patients teeth, to the scan of the patient's teeth using the scanner to create a true dimension working file; the scan of the patient's teeth using a computer system to create a true dimension working file; or a shrunk restoration file of the restoration using a restoration fabricator. A restoration can be designed based on the scan of the patient's teeth and creating a restoration file. The restoration can be fabricated using a restoration fabricator. | 2014-10-23 |
20140315155 | MOLDED DENTAL ROOT CANAL FILLING POINTS/CONES AND PROCESS OF MAKING SAME - The present invention provides an improved root canal filling point/cone that can be manufactured precisely to result in better obturation with less micro-leakage. One aspect of the present invention is directed to a molded root canal filling point/cone. Another aspect of the present invention is directed to a thermo-pressure molding process for manufacturing root canal filing appliances (e.g., Gutta Percha points). Another aspect of the present invention is directed to the structure of the mold for undertaking thermo-injection molding. A further aspect of the present invention is directed to a production line comprising the thermo-injection process. | 2014-10-23 |
20140315156 | Sighting Apparatus and Method - A remote camera target observation system and method of use, the system generally comprising one or more remote camera/wireless transmitter units comprising a video camera connected to a first wireless transmitter that can wirelessly transmit video signals from the video camera; one or more weather meter/wireless transmitter units comprising at least of a weather meter to continuously measure environmental conditions, weather meter/wireless transmitter units wirelessly transmitting data signals of measured environmental conditions made by the weather meter; a receiver/base unit that comprises a wireless receiver that connects to a computer, the computer connects to a user interface, the wireless receiver capable of receiving video signals from the one or more remote camera/wireless transmitter units and data signals from one or more weather meter/wireless transmitter units. | 2014-10-23 |
20140315157 | STATIONARY HYDRAULICALLY ASSISTED DEVICE TO TEACH MOTORCYCLE RIDING SKILLS WHILE UNDER A CONTROLLED SUPERVISED ENVIRONMENT - Some embodiments provide a hydraulically assisted stationary motorcycle training device for teaching motorcycle riding skills in a controlled and supervised environment. In some embodiments, the stationary motorcycle training device includes a set of equipment for responding to operations of a motorcycle positioned on the stationary motorcycle training device. In some embodiments, the stationary motorcycle training device is hydraulically assisted for simulating a motorcycle riding experience to a person seated on the motorcycle. includes a set of operational motorcycle equipment for learning motorcycle riding skills | 2014-10-23 |
20140315158 | Paper Craft Tool - A paper craft tool is disclosed. The paper craft tool is formed as a single piece, having a base that is formed generally in the shaped of a triangle with a rounded bottom section, a right side having an array of notched indentions, a corresponding left side having corresponding notched indentions, a first raised support having an array of peg supports disposed thereon, and a second raised support without an array of peg supports. A marking template is provided. A method and system utilizing the paper craft tool and marking template is provided. | 2014-10-23 |
20140315159 | Banking Services Experience Center - A system for creating an interactive banking experience includes: a facility for housing the interactive banking experience; a first electronic computing device for controlling the interactive banking experience, the interactive banking experience comprising one or more banking workflow scenarios; an environmental control system for creating ambient conditions corresponding to the one or more banking workflow scenarios; and a detection system for detecting gestures and voice commands from a user, the gestures and voice commands being used to activate workflow steps in the one or more banking workflow scenarios. | 2014-10-23 |
20140315160 | INFORMATION PROCESSING DEVICE AND STORAGE MEDIUM - There is provided an information processing device including a detection unit configured to detect a plurality of pieces of food which are eating targets from an image obtained by imaging eating of a user, and a recommendation unit configured to recommend at least the food to be subsequently ingested in real time among the plurality of pieces of food so that the user ingests the plurality of pieces of food detected by the detection unit in an order satisfying a predetermined purpose. | 2014-10-23 |
20140315161 | INFORMATION PROCESSING APPARATUS AND STORAGE MEDIUM - There is provided an information processing apparatus including a determination unit configured to determine whether a user is consuming food and drink or whether food and drink is present in a periphery of the user, and a control unit configured to carry out control to output a control signal to an adding unit that adds a lighting effect to one of the food and drink present in a real space and picked-up images of the food and drink in accordance with a determination result of the determination unit. | 2014-10-23 |
20140315162 | SYSTEM AND METHODS FOR MONITORING FOOD CONSUMPTION - The invention provides a system for monitoring food consumption of a subject, comprising: a registration system configured to receive food data comprising nutrients and/or calories contained in one or more food item served to the subject; an intake detection system configured to detect consumption of said one or more food item, thereby generating real-time food consumption data; and a tracking and analysis system configured to receive food data from said registration system and consumption data from said intake detection system, and configured to utilize said food data and said consumption data to calculate a total amount of one or more nutrient and/or calories consumed by the subject. The invention further provides methods for monitoring food consumption of a subject. | 2014-10-23 |
20140315163 | DEVICE, METHOD, AND GRAPHICAL USER INTERFACE FOR A GROUP READING ENVIRONMENT - The method includes receiving selection of text to be read in a group reading session; identifying a plurality of participants for the group reading session; and upon receiving the selection of the text and the identification of the plurality of participants, automatically, without user intervention, generating a reading plan for the group reading session, wherein the reading plan divides the text into a plurality of reading units and assigns at least one reading unit to each of the plurality of participants in accordance with a comparison between a respective difficulty level of the at least one reading unit and a respective reading ability level of the participant. | 2014-10-23 |
20140315164 | SYSTEM AND METHOD FOR IMPROVING OPERATOR PERFORMANCE - System and method for improving operator performance are provided. According to one embodiment, the method includes monitoring operation of a machine operated by an operator, analyzing performance of the operator based on the operation of the machine, rating the performance of the operator according to a plurality of skill levels, and adjusting capabilities of the machine according to the rating. Based on at least one of the analysis or the rating, the operator is provided with individualized guidance, which is configured to assist the operator to improve the performance of the operator. | 2014-10-23 |
20140315165 | SYSTEM FOR COSMETIC AND THERAPEUTIC TRAINING - Systems and methods are disclosed for an apparatus and method for practicing injection techniques through an injectable apparatus. The injectable apparatus may contain a camera that is configured to detect the intensity and color of light attenuated from a testing tool after it is injected into a simulated human or animal body parts. A training tool may be connected to a user display device to generate a display of the injection apparatus as well as the performance parameters of a trainee. | 2014-10-23 |
20140315166 | Portable device to manage and control air traffic control training system - A portable electronic device ( | 2014-10-23 |
20140315167 | METHOD AND DEVICE FOR SIMULATING AN ELECTRODE WELDING PROCESS - The invention relates to a method and a device ( | 2014-10-23 |
20140315168 | FACIAL EXPRESSION MEASUREMENT FOR ASSESSMENT, MONITORING, AND TREATMENT EVALUATION OF AFFECTIVE AND NEUROLOGICAL DISORDERS - Apparatus, methods, and articles of manufacture facilitate diagnosis of affective mental and neurological disorders. Extended facial expression responses to various stimuli are evoked or spontaneously collected, and automatically evaluated using machine learning techniques and automatic facial expression measurement (AFEM) techniques. The stimuli may include pictures, videos, tasks of various emotion-eliciting paradigms, such as a reward-punishment paradigm, an anger eliciting paradigm, a fear eliciting paradigm, and a structured interview paradigm. The extended facial expression responses, which may include facial expression responses as well head pose responses and gesture responses, are analyzed using machine learning techniques to diagnose the subject, to estimate the likelihood that the subject suffers from a specific disorder, and/or to evaluate treatment efficacy. | 2014-10-23 |
20140315169 | COMPUTER GENERATED THREE DIMENSIONAL VIRTUAL REALITY ENVIRONMENT FOR IMPROVING MEMORY - The present disclosure relates to a computer generated 3D virtual environment for improving memory (e.g. spatial, temporal, spatial-temporal, working and short-term memory). In an aspect, there is provided a computer-implemented method for generating a 3D virtual reality (VR) environment for improving spatial memory. In an embodiment, the method comprises executing at least one VR memory training module including one or more memory training tasks to be performed within a navigable three-dimensional (3D) environment; displaying a navigable 3D environment via an output to a display; and receiving an input from an interactive navigational controller. In another embodiment, the method may further comprise performing one or more scans of brain activity, whereby, the effectiveness of the at least one VR memory training module in targeting a region of the brain can be measured. The determination of which VR memory training modules to retrieve and execute may be made based on the measured effectiveness of a previous VR memory training module training session in targeting a selected region of the brain. | 2014-10-23 |
20140315170 | Apparatus, System, and Method to Promote Behavior Change Based on Mindfulness Methodologies - System, method, and article to prompt behavior change based on a mindfulness methodology are provided. Various aspects of the system include mindfulness promotion data generated and/or communicated from/to a device; a methodology module associated with software/processor to identify at least one behavior change methodology associated with the mindfulness promotion data; and an instruction module associated with a software/processor to initiate the identified at least one behavior change methodology. | 2014-10-23 |
20140315171 | Swim simulator with breathing practice function - The invention is related to a swimming teaching apparatus which provides user to make a complete swimming like action on land. The special technical features are a body rotation mechanism, arms guide, a breathing sink and a kick pad for legs, all together to perform on land swimming exercise. All strokes can be skilled with a precise instruction by the coach when the user is stationary on the invention. The invention allows user to do continuous practice of the swimming movements without be interrupted by a breathing problem, when the arms and legs are well coordinated, breathing sink then add to exercise, user can do combined actions slowly to ensure the correctness. The invention is tried to substitute the buoyancy of water as a pre-training machine for those schools which have no swimming pools can still carry out swimming courses for their students to reduce drowning incidents. | 2014-10-23 |
20140315172 | SYSTEMS AND METHODS FOR INTERACTIVE SCENARIO-BASED MEDICAL INSTRUCTION - Systems and methods for providing a framework (e.g. software, hardware, firmware, etc.) allow students and health professionals to learn and practice medical principles and refine essential skills in a virtual environment. The disclosed framework allows students (users) to interact with virtual patients in various scenarios, exposing users to medical illnesses and conditions. For example, the disclosed framework allows users to identify and manage different illnesses and conditions that may not be common in their geographic location, and exposes users to patient types and ethnic groups that they may not be exposed to otherwise. | 2014-10-23 |
20140315173 | Simulation Add-On Device to Allow Anterior-Posterior and/or Anterior-Lateral Defibrillation - The present invention takes the form of a device for training a user in defibrillation technique. The device includes a non-conductive belt that encircles a chest of a typical training simulator. The device includes conductive studs disposed in the AP or AL position, and therefore allows for training of the AP or AL defibrillation technique, respectively. The device can be used in conjunction with a high-technology simulator. In such a case the conductive studs redirect simulated cardiac rhythm signals and defibrillator electricity, allowing for the simulation of defibrillation in the AP position. The device can also be used in conjunction with a low-technology simulator or a pillow to provide AP and/or AL defibrillation functionality. In such a case, a rhythm simulator is used to simulate heart rhythm and dissipate defibrillation energy. | 2014-10-23 |
20140315174 | UNIVERSAL MICROSURGICAL SIMULATOR - A microsurgical simulation system includes a display for providing a virtual simulation of images of a model of a human eye and a hand-held tool for simulating a surgical tool. The hand-held tool comprises a position and orientation sensor for supplying positional signals to a processor to indicate a position and orientation of the hand held tool and a tracking system for supplying measurement signals to the processor to indicate a linear distance between a first component and a second component of the hand-held tool. A virtual representation of the hand-held tool is presented on the display, and the appearance and positioning of the virtual representation of the hand-held tool is based on the positional signals and measurement signals supplied to the processor by the hand-held device. | 2014-10-23 |
20140315175 | SYSTEM FOR SIMULATING LUNG FUNCTION - A system for simulating a breathing lung is disclosed. The system comprises a lung model contained within an enclosure, wherein a main bronchus of the lung model is open to ambient air. In one embodiment, the system also comprises a vacuum pump connected to the enclosure, a first normally closed 2-way valve connected to the enclosure, a flow controller connected to both the vacuum pump and the enclosure, and a timer connected to the first normally closed 2-way valve. In alternative embodiments, the system comprises a first pump connected to the enclosure and a second pump connected to the enclosure, wherein the first and second pumps work independently of each other, and wherein the first pump is a vacuum pump, and the second pump is either a peristaltic pump or a piston pump. | 2014-10-23 |
20140315176 | Vascular-Access Simulation System with Receiver for an End Effector - The illustrative embodiment is a simulation system for practicing vascular-access procedures without using human subjects. The simulator includes a data-processing system and a haptics interface device. The haptics device provides the physical interface at which an end effector (e.g., medical instrument, such as a needle, catheter, etc.) is manipulated to simulate needle insertion, etc. In accordance with the illustrative embodiment, the haptics device includes a receiver. The receiver receives the end effector when it's inserted by a user into the haptics device. Sensors that are associated with the receiver monitor the motion and position of the end effector, generate signals indicative thereof, and transmit the signals to the data processing system. The signals are processed to determine the effects of manipulation of the end effector. In some embodiments, the signals are processed to determine the various resistive forces that would arise if the user were manipulating a needle/catheter through actual human anatomy. Responsive to this determination, the receiver generates forces that the user experiences as a resistance to continued advance (insertion) of the end effector. Simulated results are displayed by the computer system. | 2014-10-23 |
20140315177 | GRADING DEVICE AND METHOD OF REMOTE TEACHING - A grading device used for grading a remotely-taught lesson includes a table generating module, a detecting module, a timing module, and a grading module. The table generating module generates a relationship table. The detecting module detects start events of the interaction segments, a start event of the lesson, stop events of the interaction segments, and a stop event of the lesson. The timing module times the start times of the lesson and the interaction segments, and the stop times of the lesson and the interaction segments, and further records the times of the interaction segments. The grading module obtains weights of the interaction segments corresponding to the times of the interaction segments from the relationship table and grades the interaction segments. A grading method is also provided. | 2014-10-23 |
20140315178 | Group Formation and Notification in an On-Line Course System - An on-line course system involves an On-Line Course Content Serving Web Server (OCCSWS). The OCCSWS serves, or otherwise enables the providing of, on-line course materials such as textual materials and/or a video to a large number of remotely located students. The students view the course materials and take part in the classes remotely via the internet. The OCCSWS performs volunteered user data collection, thereby obtaining for each student items of first classification information. The OCCSWS performs behavioral user data collection, thereby obtaining for each student items of second classification information. The items of first and second classification information are used to group the students into groups. The OCCSWS then communicates, to each student, an indication of the group to which the student has been assigned. The OCCSWS facilitates the students engaging in group activities, monitors the students, and if necessary prompts the students to perform certain group activity tasks. | 2014-10-23 |
20140315179 | Educational Content and/or Dictionary Entry with Complementary Related Trivia - A fast convenient process for understanding a word or phrase displayed on a computer screen. A user selects the word and instantly triggers the display of an educational content such as a definition for the word. A complementary related trivia meant to be fun also is displayed. A pop-up space can be utilized to present the educational content and the trivia. The educational content can be dictionary entries such as parts of speech, senses, and etymologies. The educational content can be other reference materials, or literary criticisms, or historical information. The educational content can be images or moving images that convey, for example, a meaning for the selected word. The complementary trivia can be related, for example, to the selected word or to the educational content. The trivia can be presented in multiple formats. The process helps a person learn about words, and the fun trivia enlivens the educational experience. | 2014-10-23 |
20140315180 | AUTOMATED ESSAY EVALUATION SYSTEM - Automated essay evaluation includes receiving an essay in text form and determining, using a processor, curriculum data for the essay. The curriculum data includes evaluation criteria for the essay and specifies an instructor. A profile for the instructor including a writing preference for the instructor is retrieved. Using the processor, a plurality of queries for the essay can be generated according the curriculum data for the essay and the profile for the instructor. Using the processor executing an inference engine, a conclusion for each of the queries is determined according to confidence scores. The essay is scored according to the conclusions. | 2014-10-23 |
20140315181 | ACADEMIC INTEGRITY PROTECTION - Methods, systems, and devices for maintaining academic integrity are disclosed herein. In some embodiments, an academic integrity system can maintain user profile data and receive integrity data. The integrity data can include data identifying one or several attributes of an actual user. This integrity data can be compared to the user profile data to determine a likelihood that the alleged user is the actual user. The likelihood that the alleged user is the actual user is compared to an academic integrity criterion. The result of this comparison is used to determine whether to request additional integrity data or to confirm or deny the identity of the actual user. | 2014-10-23 |
20140315182 | MEDIA DISPLAY STAND DEVICE APPARATUS AND METHODS - The present general inventive concept relates to the display of visual media by a media display stand apparatus and related methods. The apparatus accommodates and displays visual media, while simultaneously exposing the end-user participant to the presence of eye(s) or eye-like graphical representations. By including eye(s) or eye-like graphical representations, the end-user participant is motivated and encouraged to engage in desired behavior at higher frequency rates and longer durations than would otherwise occur in the absence of such eye(s) or eye-like graphical representations. | 2014-10-23 |
20140315183 | System for Exhibiting Different Motifs for Facades of Buildings - System for exhibiting different motifs for facades of buildings of the type intended to be superimposed on a facade of a building and comprising a large exhibiting surface and lighting means; which comprises—a plurality of transparent plates which are arranged on the outside and at a distance from a facade of said building;—a modular structure which comprises: supporting brackets which are arranged at different levels, are fixed to said building at a first end and project from said facade of the building; vertical tubes which are fixed on a second end of said supporting brackets by an intermediate area and are at a distance from said facade of the building; clamps for fastening said transparent plates to said vertical tubes; maintenance walkways and cable management trays fixed to the supporting brackets and situated at different levels within the exhibiting surface;—an array of LEDs which is situated behind the transparent plates and is oriented towards said transparent plates;—a computerized unit for controlling the lighting means, and;—autonomous electrical power supply means. | 2014-10-23 |
20140315184 | Combination Magnetic Board and Dry Erase Board - A combination magnetic and dry erase board includes a magnetic retaining portion having a planar substrate having properties to attract and retain a magnet thereon and a bleach-resistant covering disposed over the substrate. A dry erase portion includes a porcelain surface. The dry erase portion is adjacent to the magnetic retaining portion. The entire board is bleach resistant and can be used in a hospital or other medical environment such that the board can be disinfected with a bleach product. | 2014-10-23 |
20140315186 | IN-VITRO DIAGNOSTICS FOR CAPRINE ARTHRITIS-ENCEPHALITIS VIRUS ANTISERA AND OTHER VIRAL INTERFERENCE RELATED AGENTS - Various postulates and methodologies in using Caprine Arthritis Encephalitis Virus and other related agents to diagnose and treat HIV/AIDS as well as other related and/or non-related diseases are declared. | 2014-10-23 |
20140315187 | Pharmaceutical Product and Method of Analysing Light Exposure of a Pharmaceutical Product - A pharmaceutical product includes a container having an exterior surface and an interior chamber, an active ingredient disposed in the interior chamber, the active ingredient having a photosensitive property that changes based on at least cumulative exposure to light having a wavelength within the range between X and Y, and a layer of photosensitive material disposed on or in the container and exposed to environmental conditions contemporaneous with the active ingredient being disposed in the interior chamber. The photosensitive material is reactive to light having a wavelength within the range between X and Y to experience a property change at a threshold of cumulative exposure to light received within the range between X and Y related to the change in the photosensitive property of the active ingredient. A photosensitive device can also be disposed along a path followed by the pharmaceutical product within a facility. | 2014-10-23 |
20140315188 | ASSESSMENT OF PML RISK AND METHODS BASED THEREON - The invention provides a method of assessing the risk of occurrence of progressive multifocal leukoencephalopathy (PML) in a subject as well as a method of stratifying a subject undergoing α | 2014-10-23 |
20140315189 | CO-BINDER ASSISTED ASSAY METHODS - The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays. | 2014-10-23 |
20140315190 | METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS - According to the present teachings, compositions, kits, and methods for protein melt analysis are provided that utilizing one or more fluorophore dyes. In some embodiments, a method comprises preparing a sample by mixing at least one protein with two or more dyes, and applying a controlled heating, while recording the fluorescence emission of the sample. The methods can be used, for example, for screening conditions for optimized protein stability, screening for ligands that bind and enhance protein stability (e.g., protein-protein interactions), screening for mutations for enhanced stability, screening crystallization conditions for protein stability, screening storage conditions for protein stability, and screening conditions in which a protein will be used (e.g., production conditions, treatment conditions, etc.) for protein stability. | 2014-10-23 |
20140315191 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS - This invention provides a process for sequencing single-stranded DNA employing modified nucleotides. | 2014-10-23 |
20140315192 | Characterizing Prostate Cancer - Methods and kits for predicting the course or aggressiveness of prostate cancer include detecting the methylation status of various genes. | 2014-10-23 |
20140315193 | Kits and Methods for Assessing Antioxidant Requirement of a Human - The invention relates to kits and methods for assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH | 2014-10-23 |
20140315194 | METHODS OF DIAGNOSING CANCER IN A PATIENT - The present disclosure relates to methods for determining the presence, activity, and/or concentrations of certain cancer biomarkers and their use in determining the presence of cancer. | 2014-10-23 |
20140315195 | METHOD FOR EXOSOMAL BIOMARKER DETECTION BY ELECTRIC FIELD-INDUCED RELEASE AND MEASUREMENT - The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules. | 2014-10-23 |
20140315197 | MULTIFUNCTIONAL PROBE-PRIMERS - Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined. The detection step makes use of a multifunctional “self-digesting” molecular probe comprising a primer polynucleotide and a probe oligonucleotide, linked in a 5′-5′ orientation. | 2014-10-23 |
20140315198 | DACH1 AS A BIOMARKER FOR DIABETES - The present invention provides a method for assessing the presence and risk of developing type 2 diabetes or cardiovascular disease in a subject by detecting sequence variation in DACH1 (Dachshund homolog 1) gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating type 2 diabetes or cardiovascular disease in patients who have been tested and shown to have the pertinent genetic variations. | 2014-10-23 |
20140315199 | GENE FUSIONS AND GENE VARIANTS ASSOCIATED WITH CANCER - The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same. | 2014-10-23 |
20140315200 | DETERMINING FETAL GENOMES FOR MULTIPLE FETUS PREGNANCIES - Techniques are provided for determining inheritance of maternal and paternal haplotypes in preganncies with multiple fetuses. Maternal inheritance can be determined at loci where the mother is heterozygous and the paternally inherited alleles are known (e.g., the father is homozygous). Two types of loci may be used, where one type has the paternal allele appear on a first maternal haplotype, and another type has the paternal allele appear on a second maternal haplotype. Paternal inheritance can be determined from loci where the father is heterozygous and the maother is homozygous. Amounts of different alleles at each locus can be measured. A comparison of the amounts (e.g., using a fractional concentration of each allele and cutoffs) can be used to determine the haplotype inheritance. A haplotype can be linked to a condition of interest. | 2014-10-23 |
20140315201 | METHOD FOR HIGH-THROUGHPUT SCREENING OF TRANSGENIC PLANTS - The invention relates to a method for quantifying levels of expression and/or quantifying copy number of a heterologous polynucleotide in a transgenic plant using quantitative or real-time polymerase chain reaction (QPCR or real-time PCR), wherein the real-time PCR is performed using a primer set specific to a heterologous terminator sequence operably linked to the heterologous polynucleotide. | 2014-10-23 |
20140315202 | METHOD FOR ASSEMBLING MULTIPLE TARGET LOCI TO SINGLE NUCLEIC ACID SEQUENCE - A method for assembling multiple target loci to a single assembled nucleic acid sequence involves assembling the multiple target loci to a single assembled nucleic acid sequence through two polymerase chain reactions (PCRs). A pair of primers for a primary amplification include a target-specific sequence and a 5′-flanking assembly spacer sequence. A primary amplified product amplified by the pair of primers for a primary amplification is assembled to a single shortened nucleic acid sequence in a convenient and easy manner through a set of primers for a secondary amplification, thus enabling the simultaneous detection of multiple target loci. Accordingly, the method and a kit of the present invention may simultaneously detect and analyze multiple variabilities in DNA sequences of a sample, thus remarkably reducing sequencing costs for detecting variabilities, and providing a critical approach and means for achieving the concept of customized medicine. | 2014-10-23 |
20140315203 | DNA METHYLATION IN COLORECTAL AND BREAST CANCER DIAGNOSTIC METHODS - The present invention relates generally to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset or predisposition to the onset of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset and/or progression of a large intestine or breast neoplasm, such as an adenoma or adenocarcinoma. The DNA methylation status of the present invention is useful in a range of applications including, but not limited to, those relating to the diagnosis and/or monitoring of colorectal or breast neoplasms, such as colorectal or breast adenocarcinomas. Accordingly, in a related aspect the present invention is directed to a method of screening for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in DNA methylation of one or more nucleic acid molecules. The nucleic acid molecules used for diagnostics in the present invention are sequences from LOC 100526820, subsequently named CAHM (colorectal adenocarcinoma hypermethylated). | 2014-10-23 |
20140315204 | Immunohistochemistry Detection Method - The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (THC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats. The invention is also compatible with many different types of targets, probes, and detectable labels. | 2014-10-23 |
20140315205 | TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS - Disclosed are composition and methods for treating immune disorders. Also disclosed are diagnosis methods and prognosis methods. | 2014-10-23 |
20140315206 | Scanning System and Method for Imaging and Sequencing - A scanning detection system is provided wherein emissions from locations in a flow cell are detected. In some embodiments, the system can comprise an excitation source, a photocleavage source, and modulating optics configured to cause an excitation beam generated by the excitation source to irradiate a first group of the fixed locations and to cause a photocleavage beam generated by the photocleavage source to irradiate a second group of the fixed locations, which is separate and apart from the first group of fixed locations. Methods of detecting sequencing reactions using such a system are also provided. | 2014-10-23 |
20140315207 | MOLECULAR BEACON BASED ASSAY FOR THE DETECTION OF BIOMARKERS FOR BREAST CANCER METASTASIS - The invention encompasses molecular beacon (MB) probes for monitoring the presence of human breast cancer biomarkers and for the analysis of breast cancer metastasis. The molecular beacon is an oligonucleotide probe which sensitively and specifically identifies biomarker mRNA in samples, in the presence of serum, in minimal time using fluorescence detection. The molecular beacons may be comprised in kits for the detection/quantitation of cancer biomarkers in clinical samples. The invention provides improvements in simplicity, accuracy, and speed over current methods, which could allow for improved patient treatment and prognoses. | 2014-10-23 |
20140315208 | METHOD FOR PREDICTING RISK OF PORENCEPHALY OR CEREBRAL HEMORRHAGE - As a result of intensive screening on mutations of the COL4A2 gene in 35 Japanese patients with porencephaly, it was found that the COL4A2 gene is a causative gene for familial and sporadic porencephalies. Since an identical heterozygous mutation of the COL4A2 gene was found in both a porencephaly patient and healthy individuals, this pathogenic mutation is considered to be dominantly inherited with incomplete penetrance. It can be predicted that a living body having a COL4A2 gene mutation has a high risk of occurrence of porencephaly and/or cerebral hemorrhage. | 2014-10-23 |
20140315209 | MOLECULAR ASSAY FOR THE AMPLIFICATION AND DETECTION OF KPC GENES RESPONSIBLE FOR HIGH-LEVEL RESISTANCE TO CARBAPENEM IN GRAM NEGATIVE BACTERIA - Methods and kits useful for the detection and identification of carbapenem-resistant pathogens harboring carbapenemase-encoding nucleic acids. Said methods comprise PCR amplification of a target region of the beta-lactamase encoding | 2014-10-23 |
20140315210 | METHODS RELATING TO IDIOPATHIC PULMONARY FIBROSIS (IPF) - The invention concerns methods of classifying patients having idiopathic pulmonary fibrosis (IPF) and of determining a preferred therapy for the treatment of IPF based on the presence or absence of the C1234T polymorphism in the toll-like receptor 3 (TLR3) gene of such patients. | 2014-10-23 |
20140315211 | METHODS FOR SUPPRESSION PCR - Provided herein are approaches for the detection, identification, and/or selective amplification of specific target species or target variants of nucleic acid sequences, even within an excess of unwanted similar sequences or variants. These approaches include methods, assays, and kits for suppression PCR that require, in part, DNA polymerase that lacks 5′-3′ exonuclease activity, and a PCR primer, termed a forward selective primer or a nunchaku primer. The methods, assays, and kits provided herein are useful for a wide variety of applications, including cancer screening assays and kits, personalized screening assays, SNP (single nucleotide polymorphism) genotyping and identification, and downstream applications such as next generation high-throughput genomic sequencing and library construction. | 2014-10-23 |
20140315212 | ALPHA TOXIN DETECTION OF GPI ANCHORED PROTEINS - The present invention relates to a method for the purification, concentration and identification of glycosylphosphatidylinositol anchored proteins (GPI-APs) from a biological sample (cells, tissues and/or blood/serum) in a patient or subject, including a human patient or subject. A new method to separate GPI-anchored glycoproteins, a class of glycoproteins found in all animal cells and fluids including serum, from other glycoproteins and proteins for the purpose of identifying potential biomarkers for various diseases, including cancer, especially breast cancer, vaginal cancer, endometrial cancer, uterine cancer, cervical cancer, pancreatic cancer and prostate cancer. The method uses the alpha-toxin from | 2014-10-23 |
20140315213 | SYSTEM FOR DETECTING RARE CELLS - This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide. | 2014-10-23 |
20140315214 | CHAPERONE INTERACTION ASSAYS AND USES THEREOF - In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein activity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some aspects, the invention provides methods for identifying and/or characterizing compounds and/or for assessing compound specificity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some embodiments, a client protein is a kinase. In some embodiments, a compound is a kinase inhibitor. In some aspects, the invention provides methods of profiling kinase inhibitor specificity. In some aspects, the invention provides assay systems and/or reagents useful for performing one or more of the inventive methods. In some aspects, the invention provides newly identified targets of a variety of kinase inhibitors. In some aspect, the invention provides methods of inhibiting kinases identified herein as targets of certain kinase inhibitors. In some aspects, the invention provides methods of treating a disease, e.g., cancer, by inhibiting one or more kinase(s) newly identified as targets of certain kinase inhibitors. | 2014-10-23 |
20140315215 | THERMOSTABLE ASSAY REAGENTS - There is provided a single-chain fusion protein comprising: (i) a thermostable kinase and (ii) a single-domain antibody or single-domain antibody fragment. There is also provided a method of preparing a single-domain antibody or single-domain antibody fragment, the method comprising: (i) expressing the single-domain antibody or antibody fragment as a single-chain fusion protein with a thermostable kinase, in a host cell such as | 2014-10-23 |
20140315216 | Immunoassay Test Slide - An immunoassay test slide for use in a dry chemistry analytical instrument includes a slide housing or case formed from two matable sections—a slide cover piece and a slide bottom piece. The slide housing defines an interior cavity in which is situated a sheet-like porous carrier matrix. The slide cover piece has an opening formed through the thickness thereof to expose a central portion of the fluid flow matrix so that a precise volume of fluid sample of blood, serum or the like, preferably pre-mixed with a conjugate reagent, and precise volumes of a wash reagent and a substrate (detector reagent), may be deposited on the matrix through the cover opening by a metering device of the analytical instrument. The bottom piece of the immunoassay test slide is transparent, and the slide is moved by a transport mechanism of the analytical instrument over a reflectometer or a fluorometer for performing reflectance or fluorescence measurements. | 2014-10-23 |
20140315218 | NEW METHOD FOR EVALUATION OF TARGET IN HISTOLOGICAL SAMPLE - The present invention lies in the field of visualization and quantification of immobilized targets in samples using immunochemical means. In particular, the invention relates to a method and reagents for detection, visualization and quantification of a molecular target in immunostained histological samples using particular compositions of the target specific binding agent. Methods and compositions of the invention are suitable for any assay that uses a target visualization system in histological samples based on detection of the target by the target specific binding agent. The methods and compositions are useful for evaluation of targets that are biomarkers of diseases in medical diagnostic. | 2014-10-23 |
20140315219 | Rapid Enzyme-Linked Immunosorbant Assay for Detection and Identification of Pathogens and Determination of Antimicrobial Susceptibility - The present invention provides a rapid, highly sensitive and specific enzyme-linked immunosorbent assay (ELISA), referred to as N-Assay, a device, and a kit, for detection and identification of microorganisms in a sample, in thirty minutes or less, with little or no interference from non-target microorganisms. The present invention also provides for simultaneous determination of antimicrobial susceptibility of microorganism in the N-Assay. | 2014-10-23 |
20140315220 | CELLULAR RECOGNITION CONJUGATES AND METHODS OF USE FOR THE HISTOLOGICAL ANALYSIS OF CANCER TISSUE USING MALDI-MS IMAGING - Disclosed are conjugates that can bind to one or more site on cancer cell surface, for example, surface proteins, compound specific receptors and carbohydrates that comprise the surface of specific cell types. The disclosed conjugates can thereby serve as indicators identifying the presence of cancerous tissue. | 2014-10-23 |
20140315221 | DEVICES AND METHODS FOR THE DETECTION OF STREP A - The present disclosure relates to devices and methods for rapidly detecting streptococcus bacteria. An illustrative device includes a first elongate handle connected to a first edible portion and a second elongate handle connected to a second edible portion. The first and second elongate handles are connected by a banding material. The first and second edible portions are inserted into the mouth of an individual for receiving a saliva sample. | 2014-10-23 |
20140315222 | METHOD FOR MEASURING SIALIC ACID IN IMMUNOGLOBULIN G AND IMMUNOGLOBULIN G ANTI-DOUBLE-STRANDED DNA ANTIBODIES - A method for measuring the amount of sialic acid in immunoglobulin G and immunoglobulin G anti-ds DNA antibodies is disclosed. The method for measuring the amount of sialic acid in immunoglobulin G in the present invention uses culture fluid, blood, plasma, or serum to directly measure the amount of sialic acid in immunoglobulin G. Also, using a mouse monoclonal antibody immunoglobulin G as a standard, which is diluted from 1000 ng/ml to 15.625 ng/ml in phosphate buffered saline (PBS), produces good results. The method for measuring the amount of sialic acid in immunoglobulin G anti-ds DNA antibodies has never been done and the present invention produces good results as well. | 2014-10-23 |
20140315223 | Method of Simultaneous Detection of Heparin-Induced Immunoglobulins Types G, A, and M - The invention provides a method for detecting heparin-induced antibodies comprising a) binding a PF4-heparin antigen to a solid surface; b) incubating the bound PF4-heparin with a sample comprising heparin-induced antibodies to be detected; c) contacting the sample with at least two labeled secondary antibodies, wherein the secondary antibodies bind to heparin-induced antibodies present in the sample; d) detecting the presence of the labeled secondary antibodies using flow cytometry or a suitable method, wherein the heparin-induced antibodies bound to the secondary antibodies are identified. In one embodiment, the at least two secondary antibodies are anti-human antibodies which specifically bind to heparin-induced antibodies and are selected from the group consisting of Ig, IgG, IgA, and IgM. | 2014-10-23 |
20140315224 | DETECTION DEVICE, DETECTION STRIP, AND DETECTION SYSTEM - A detection device applied for detecting body fluids includes a substrate and a plurality of anti-growth factor antibodies. The substrate includes at least one reaction portion. The reaction portion includes a fiber-based material. Anti-growth factor antibodies are disposed on the fiber-based material. The present invention further provides a detection strip and a detection system for detecting body fluids. The present invention is advantageous for easy operation, lower amount of reagents and rapid analysis. | 2014-10-23 |
20140315225 | METHODS AND COMPOSITIONS FOR DETECTING THE PRESENCE OF ONE OR MORE AUTOANTIBODIES - This disclosure describes methods and compositions for immunohistochemically detecting the presence of a SRP autoantibody in a biological sample. | 2014-10-23 |
20140315226 | Device And Method For Detecting Substances Present In Biological Or Chemical Samples - The present invention relates to a device and a method for detecting substances which are present in biological or chemical samples, each substance producing an optically detectable signal upon reaction with a reagent. The device further comprises a sample carrier with at least two receptacles for receiving samples and is characterized in that at least part of the receptacle is equipped to receive at least 2 reagents each, and in that a camera for recording an image which shows at least one receptacle filled with at least two reagents for the detection of different substances, and an evaluation device for evaluating the samples which device is designed such as to evaluate each image by analyzing the signals in the image. Said method comprises the following steps: Introducing at least two reagents into one receptacle of a sample carrier, and optionally immobilizing the reagents, adding the sample to the receptacle, recording an image by means of a camera such that the image shows the receptacle which is loaded with at least two reagents, and evaluating the image by analyzing the color spectrum of the samples in the image. | 2014-10-23 |
20140315227 | THERAPEUTIC AGENT FOR PRETERM DELIVERY OR ABORTION USING PLASMINOGEN ACTIVATOR INHIBITOR-1 - The present invention relates to a method for diagnosing the degree of risk for preterm delivery or miscarriage, comprising measuring plasminogen activator inhibitor activity or level in plasma. Specifically, the present invention relates to: a method for diagnosing the degree of risk for preterm delivery or miscarriage, wherein when the plasminogen activator inhibitor activity or level is lower than those of normal pregnant woman, the degree of risk for preterm delivery or miscarriage is determined to be high; a kit for the diagnosis of the degree of risk for preterm delivery or miscarriage; and a pharmaceutical composition for the prevention of preterm delivery or miscarriage, comprising plasminogen activator inhibitor-1. | 2014-10-23 |
20140315228 | APPARATUS AND METHOD FOR ANALYZING BLOOD CLOTTING - Systems, apparatuses and methods include evaluation the clotting time or strength of clotting in the presence of various clot-affecting reagents to obtain a profile of clot analysis for determination of bleeding complications. The various reagents may be included in a single cartridge for use in a blood clotting analysis device. | 2014-10-23 |
20140315229 | TESTING SYSTEM ARRANGEMENT AND METHOD FOR TESTING - This invention relates to a testing system arrangement for assessing the level of a biochemical marker, comprising a disposable device ( | 2014-10-23 |
20140315230 | PROCESS FOR RAPIDLY SCREENING ENZYME AND ENZYME MIXTURES FOR THE HYDROLYSIS OF LIGNO-CELLULOSIC BIOMASS - The invention is to a novel method for evaluating the hydrolysis conversion of a enzyme or enzyme mixture relative to a specific ligno-cellulosic biomass. The method evaluates the hydrolysis conversion of a enzyme or enzyme mixture relative to a specific ligno-cellulosic biomass by preparing a pretreated ligno-cellulosic biomass suspension, a buffer solution and an enzyme or enzyme mixture solution; dispensing a portion of one or more of the three components into a plurality of test vials, subjecting one or more of the plurality of test vials to varying incubation periods, reducing the rate of incubation at the end of each incubation period, and analyzing the resulting samples for dissolved sugars to determine the rate of reaction. | 2014-10-23 |
20140315231 | QUANTIFICATION OF TRANSTHYRETIN AND ITS ISOFORMS - The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods. | 2014-10-23 |
20140315232 | METHOD FOR DOSING THE CONTROL CAPACITY OF C1INH - The present invention relates to a method for dosing the control capacity of plasma serpin (SERine Protease INhibitor) C1 inhibitor (C1Inh) on the basis of a patient blood sample. The invention also relates to a kit specially designed for said dosing. | 2014-10-23 |
20140315233 | BUFFERED HISTOLOGY AND CYTOLOGY STAINS - A composition for use in staining histological and cytological tissue and cell samples which includes a buffer component in a staining solution. Specifically, the invention relates to stains and methods of producing stains for histological and cytological microscopic evaluation of tissue and cells. The buffer component is adjusted to a pH range below the isoelectric point (IEP) necessary to charge the protein or protein moiety of interest. The composition of a dye and solvent with a buffer component is particularly useful in obtaining controlled staining specificity of tissue elements or components, increasing reproducibility of the staining results, and increasing shelf-life of the staining reagent. | 2014-10-23 |
20140315234 | METHOD TO GENERATE DOPAMINERGIC NEURONS FROM MOUSE AND HUMAN CELLS - The present invention relates to a method for reprogramming a differentiated non neuronal cell into a dopaminergic neuron comprising the step of inducing the expression in the differentiated non neuronal cell of at least the protein encoded by the Mash1 human gene or orthologues thereof and the protein encoded by the Nurr1 human gene or orthologues thereof, expression vectors, reprogrammed dopaminergic neuron and uses thereof. | 2014-10-23 |
20140315235 | Coated Fiber Scaffold for Three Dimensional Cell Culture of Neural Cells - The invention relates to a biocompatible scaffold for three dimensional cultivation of cells, said scaffold comprise one or more fibers randomly oriented to form a scaffold with open spaces for cultured cells. The one or more fibers are also coated with a bio-active coating and have a diameter of 100-3000 nm. | 2014-10-23 |
20140315236 | Method and Apparatus for the Processing and/or Analysis and/or Selection of Particles, in Particular, Biological Particles - Methods and apparatus are described for the processing (for example washing, incubation, etc.) of particles in which the particles suspended in a first fluid are introduced under laminar flow conditions into at least one first microchamber or first region of the same, in which a second fluid is introduced under laminar flow conditions into at least one second region of the microchamber or of a second microchamber, in such a way as not to mix with the first fluid, and in which at least one field of force acting on the particles is activated in the microchamber(s), to provoke a shift of the particles alone in a predetermined direction and to transfer the same in suspension into the second fluid; an apparatus is preferably used including at least three microchambers n microchambers arranged in sequence with each other in one direction and each connected with the microchamber immediately before it and after it with two orifices offset from each other in a direction perpendicular to the direction of sequence of the microchambers. | 2014-10-23 |
20140315237 | CAPTURING OF CELL FLUID AND ANALYSIS OF ITS COMPONENTS UNDER OBSERVATION OF CELLS AND INSTRUMENTS FOR THE CELL FLUID CAPTURING AND THE ANALYSIS - A method captures cellular components from a single cell and performs mass spectrometry on the components. The method includes inserting a nanospray ionization capillary tip into a specific region of the cell under observation with a microscope. The nanospray ionization capillary tip can include a filament in the interior. The method further includes capturing the cellular components of the specific region of the cell into the opening of the nanospray ionization capillary tip and keeping the components at the nanospray ionization capillary tip, supplying an ionization supporting solvent from a back-end of the nanospray ionization capillary tip, applying an electric field between a sample inlet of a mass spectrometer and the nanospray ionization capillary tip, whereby nanospray ionization to the cellular components is implemented, and performing the mass spectrometry on the cellular components captured at the nanospray ionization capillary tip. | 2014-10-23 |
20140315238 | SHEATH FLUID SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES - Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. | 2014-10-23 |
20140315239 | Tool and Method for Validating Operational Performance of a Photoluminescence Based Analytical Instrument - A reference vessel and a method of validating operational integrity of an analytical instrument using the reference vessel. The reference vessel has certain design features that render it particularly suited for interrogation by a specific analytical instrument, and is equipped with a surrogate probe that generates a perceptible signal of known value when interrogated by that instrument regardless of the actual value of the variable in communication with the surrogate probe. | 2014-10-23 |
20140315240 | RAPID MEASUREMENT OF FORMED BLOOD COMPONENT SEDIMENTATION RATE FROM SMALL SAMPLE VOLUMES - Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data. | 2014-10-23 |
20140315241 | MICROSENSOR - The present invention relates to a miniature device for detecting, identifying and/or quantifying microorganisms in a sample. The device comprises a surface for contact with a sample to be analysed, said surface defining a pore and said pore comprising means for reporting the presence of a microorganism. The reporting means may comprise a solid or semi-solid substrate, a metabolic indicator; and a media and/or nutrients that support or encourage microbial growth. | 2014-10-23 |
20140315242 | Microfluidic Chamber Assembly for Mastitis Assay - The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to use the device to observe leukocytes in a mono-layer for the purpose of disease detection, cell counts or the like. | 2014-10-23 |
20140315243 | PROCESSES FOR PRODUCING FERMENTATION PRODUCTS - The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase, a thermostable protease, and optionally a carbohydrate-source generating enzyme and/or pullulanase, are present and/or added during liquefaction. The invention also relates to compositions suitable for use in a process of the invention. | 2014-10-23 |
20140315244 | NOVEL FUNGAL STRAIN BEAUVERIA SP. MTCC 5184 AND A PROCESS FOR THE PREPARATION OF ENZYMES THEREFROM - A fungal strain | 2014-10-23 |
20140315245 | EXPRESSION OF BIOLOGICALLY ACTIVE PROTEINS IN A BACTERIAL CELL-FREE SYNTHESIS SYSTEM USING BACTERIAL CELLS TRANSFORMED TO EXHIBIT ELEVATED LEVELS OF CHAPERONE EXPRESSION - The present disclosure describes methods and systems for improving the expression of a properly folded, biologically active protein of interest in a cell free synthesis system. The methods and systems use a bacterial cell free extract having an active oxidative phosphorylation system, and include an exogenous protein chaperone. The exogenous protein chaperone can be expressed by the bacteria used to prepare the cell free extract. The exogenous protein chaperone can be a protein disulfide isomerase and/or a peptidyl-prolyl cis-trans isomerase. The inventors discovered that the combination of a protein disulfide isomerase and a peptidyl-prolyl cis-trans isomerase produces a synergistic increase in the amount of properly folded, biologically active protein of interest. | 2014-10-23 |
20140315246 | COMPOSITE SUGAR CHAIN HYDROLASE - The present invention provides a novel endo-β-N-acetylglucosaminidase (Endo-Om) using a transformant produced by cloning an endo-β-N-acetylglucosaminidase (Endo-Om) gene originated from a methylotrophic yeast | 2014-10-23 |
20140315247 | Expression Cassette, Use of the Expression Cassette, Expression Vector, Prokaryotic Host Cell Comprising Expression Vector, Bacterial Strain and a Method for Producing a Polypeptide - The subject matters of invention relate to expression cassette, use of the expression cassette, expression vector, prokaryotic host cell harbouring expression vector, bacterial strain, and method for producing a polypeptide. In more detail, the invention relate to stable expression of recombinant polypeptides, in systems with no need of using antibiotics. Particularly, stable expression of recombinant proteins obtained with the use of very efficient T7 polymerase/promoter system. | 2014-10-23 |
20140315248 | PROTEIN PRODUCTION METHOD USING TRANSFORMED PLANT CELLS - An object of this invention is to produce a protein by efficiently culturing plant cells while escaping mRNA translational repression in cultured plant cells under stress caused by lack of conditions essentially required for the growth (e.g., nutrient-starvation stress and hypoxic stress). This invention provides a method for escaping translational repression of a protein encoded by mRNA, the repression being induced by stress due to absence of conditions required for the growth, the method comprising the step of culturing a plant cell transformed with a recombinant DNA molecule encoding mRNA containing 5′ UTR defined in (a) or (b) below, the culturing being carried out under stress due to absence of conditions required for the growth: (a) 5′ UTR having a base sequence of SEQ ID NO: 1, 2, 3, 4, 5, or 6; or (b) 5′ UTR having the base sequence of the 5′ UTR of (a) in which one or more bases are replaced, deleted, or added, and which escapes translational repression induced by stress due to absence of conditions required for the growth. | 2014-10-23 |
20140315249 | INDUCIBLE EUKARYOTIC EXPRESSION SYSTEM - Compositions and methods for the inducible expression of genes in eukaryotic cells are provided. Expression of a nucleotide sequence of interest encoding a protein of interest is controlled by a regulatory fusion protein that consists of a transcription blocking domain and a ligand-binding domain. When a cognate ligand for the ligand-binding domain is present, transcription of the nucleotide sequence of interest is blocked. Upon removal of the cognate ligand, the nucleotide sequence of interest is transcribed. The method is useful for large scale bioreactor production of a desired protein of interest in eukaryotic cells. | 2014-10-23 |
20140315250 | HUMANIZED ANTIBODIES AGAINST TL1A - Disclosed are humanized antibodies that bind specifically to TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function. | 2014-10-23 |
20140315251 | Interleukin-31 Monoclonal Antibody - An isolated antibody that specifically binds to at least one of canine Interleukin-31 (IL-31) or feline IL-31 is provided. Such antibodies can be in the form of diagnostic and/or veterinary compositions useful for treating a pruritic and/or allergic condition in dogs or cats. | 2014-10-23 |
20140315252 | CD40L EXPRESSING MAMMALIAN CELLS AND THEIR USE - Herein is reported a co-cultivation system for co-cultivating a pool of rabbit B-cells or single deposited rabbit B-cells wherein cells CD40L expressing CHO cells are used as feeder in the presence of IL-2 and IL-21. | 2014-10-23 |