43rd week of 2008 patent applcation highlights part 46 |
Patent application number | Title | Published |
20080261184 | Measurement Instruction Apparatus - A multi-scaled instructional apparatus is provided in which a plurality of measurement scales are disposed on a base medium. Each of the measurements scales are longitudinally aligned such that equal units of measure are commonly aligned among all of the measurement scales. A first measurement scale is provided in which a plurality of uniquely color-coded base units of measurement are periodically disposed on the base medium. A second measurement scale, uniformly aligned and adjacent to the first measurement scale includes a plurality of color-coded subunits of measurement periodically disposed on the base medium. Each set of subunits equaling one half of each base unit and color-coded in a color shade corresponding to the color of the base unit. An elongated element is provided to receive the base medium. | 2008-10-23 |
20080261185 | SIMULATED TEACHING ENVIRONMENT - Embodiments of the disclosure may provide a method, system, and computer program configured to simulate a teaching environment for educational training. The method may include displaying an empty simulated classroom environment for an orientation period, displaying an occupied classroom environment for at least one classroom period, generating and displaying a plurality of events, both disruptive and non-disruptive during the at least one classroom period, identifying at least one of the plurality disruptive or non-disruptive events on a display, addressing the at least one identified event, scoring training performance for the simulated teaching environment based on the identifying and addressing actions, and using a score representative of the training performance to add enhancements to a subsequent teaching simulation. | 2008-10-23 |
20080261186 | Implicit attitude trainer - An automated method and computer interface for stimulating a user to develop and/or alter their implicit attitudes towards behavioural objects, such as dieting, alcohol consumption or exercising etc. The method comprising presenting a series of stimuli to the user within a test environment, each stimulus being associated with a behavioural object. The test environment may be a computer display screen, wherein the method designates a first zone within the environment as a positive behavioural association region and designates a second zone within the environment as a negative behavioural association region. The method further prompting the user to categorise each stimulus by moving the stimulus to either the first zone or the second zone, wherein positively categorising stimuli causes the user to develop improved implicit attitudes towards the behavioural objects associated with those stimuli in the first zone. The invention is particularly suited for implementation within web-browser and desktop environments. | 2008-10-23 |
20080261187 | Behavior Modification Bracelet With Quantity Indicators - A behavior modification bracelet with quantity indicator comprising a band having an outer major cylindrical surface featuring at least one metric indicia visible and at least one sliding component for marking the metric indicia. | 2008-10-23 |
20080261188 | Rosary Key - The rosary key is a one-piece, hand-held device to prompt the recitation of the rosary. Critical elements of the traditional rosary pendent are evoked by tactile design. The counting of a decade of Hail Marys is measured by the finger movement of a bead-like button through the ten “stops” of the channel. The “Our Father” or Lord's Prayer, preceding each decade, is recited while fingering a separate rotating bead. Fingering of button and bead serve to preserve the essential contemplative nature of traditional rosary use. Furthermore, the rotating bead, in independent function, prompts use as a pocket or keychain comfort/prayer object, meditative through repetitive fingering alone. | 2008-10-23 |
20080261189 | Internet Lesson System - There is provided an Internet lesson system, in which even if training person and the adviser are respectively in the remote place, lessons of motions of sports, performance or action, etc. can easily be performed through the Internet. In the Internet lesson, there is two screen tool on WEB, the system is downloaded from the Internet when necessary at any time, the adviser inputs the line tool and the voice onto two screens from backward, forward the and side and transmits, and animation with line tool and voice to PC or cellular phone of training person. | 2008-10-23 |
20080261190 | APPARATUS AND RELATED METHODS FOR THE CONTROLLED ILLUMINATION OF A CONVEX SURFACE - Illumination provided to the interior of a convex surface can be controlled using a plurality of internal barriers separating light sources such as light emitting diodes. Such controlled illumination can simulate phases of the moon using logic which can be limited to yes or no Boolean decisions, thereby minimizing the complexity of required input. | 2008-10-23 |
20080261191 | Scaffolding support for learning application programs in a computerized learning environment - A computerized learning system is provided. The computerized learning system may include a learning application program executable on a computing device. The learning application program may have a user interface configured to present a challenge to a user and receive a user response to the challenge. The user interface may feature a support system configured to present support to aid the user in responding to the challenge. To adjust the support provided to the skill level of the user, a scaffolding engine may be provided to determine a scaffolding level of the user for a skill, and the support system may be configured to adjust the support in response to the scaffolding level. In this manner, support for the user may be more appropriately tailored to the user's ability and change dynamically in accordance with the user's progress. | 2008-10-23 |
20080261192 | SYNCHRONOUS MULTI-MEDIA RECORDING AND PLAYBACK WITH END USER CONTROL OF TIME, DATA, AND EVENT VISUALIZATION FOR PLAYBACK CONTROL OVER A NETWORK - A system and system are provided for providing synchronous multimedia recording and playback. Aspects the exemplary embodiment include in response to a training session is being conducted, synchronously recording in real-time simulator data from a simulator captured by a simulator capture tool, and video of the training session captured by a plurality of A/V sources; encoding each of the videos captured by the plurality of A/V sources as respective digital media files formatted as streaming media; and transmitting both the simulator data and the video media files from a server to a client over a network, such that when the client receives the simulator data and the stream, the respective videos are synchronously played back with the simulator data on the client | 2008-10-23 |
20080261193 | Management Information System - A management information system, computer implemented method and computer product for managing tutoring services. A networked server is provided which includes a processor, a memory coupled to the processor and a database operatively stored in the memory. The database comprises a first database component operative to maintain a plurality of tutor records, each tutor record being associated with an individual tutor and including tutoring data representing an available tutoring subject and a tutoring locality; a second database component is operative to maintain a plurality of student records, each student record being associated with an individual student and including student data representing a requested tutoring subject and a student locality. A database engine is operatively loaded into the memory and includes instructions executable by the processor to determine a suggested tutor/student allocation in dependence on a correspondence of at least the data representing a tutoring subject and locality among the tutor and student records, generate a suggested tutor/student allocation and output the suggested tutor/student allocation in a tiered order of preference of tutors and sends notices to the identified tutors. | 2008-10-23 |
20080261194 | Method and apparatus for implementing an independent learning plan (ILP) based on academic standards - A process for generating and deploying a real-time automatic independent learning plan (ILP) for a person based on academic curriculum standards. More specifically, an automated process is disclosed that includes as a first step testing and remediation for students to determine the assessment of that student's competency and mastery of certain academic disciplines, followed by the automatic generation, based on such assessment, of an ILP, which is a unique and individualized set of learning content assembled to assist the particular student in learning one or more process standards. | 2008-10-23 |
20080261195 | Written examination system and written examination device - There is provided a written examination system in which paper consumption and flowing out of examination questions in a written examination may be prevented. The written examination system according to the present invention comprises: a display device | 2008-10-23 |
20080261196 | NAPHTHALENE DIIMIDE-ZN(II) COMPLEX HAVING SELECTIVITY FOR PYROPHOSPHATE, PREPARATION METHOD THEREOF AND DETECTING METHOD OF PYROPHOSPHATE USING THE SAME - The present invention provides a novel fluorescent chemosensor including a naphthalene diimide-Zn(II) complex, which can efficiently recognize pyrophosphate (PPi) at pH 7.4. The fluorescent chemosensor exhibits a new kind of excimer fluorescence, which is selective for PPi in 100% aqueous solution. Further, since the naphthalene diimide-Zn(II) complex of the present invention does not couple with inorganic phosphate (Pi) or adenosine triphosphate (ATP) and has high selectivity for PPi, it can be usefully used to detect pyrophosphate (PPi), which serves to transfer signals and store energy in living organisms. | 2008-10-23 |
20080261197 | Nucleotide sequences of HIV-1 group (or subgroup) O retroviral antigens - An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies isolated from a serum resulting from infection by an HIV-1 type O VAU strain or an HIV-1 type (or subtype) O DUR strain. | 2008-10-23 |
20080261198 | Diagnostic Primers and Method for Detecting Avian Influenza Virus Subtype H5 and H5n1 - The present invention provides primers directed to conserved regions of the HA and NA genes of avian influenza virus subtypes H5 or H5N1, and provides a method for detecting avian influenza subtype H5 or H5N1. | 2008-10-23 |
20080261199 | RAPID DETECTION PROCESSES AND RELATED COMPOSITIONS - An improved detection method is described for an antigen such as a chemical compound, a peptide, or a nucleic acid. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can particularly be used, for example, to modify and reduce the detection time significantly in traditional Western blot, Dot blot, ELISA and Immunohistology methods. | 2008-10-23 |
20080261200 | Detection of Nucleic Acid Mutations - A method for detecting a mutation in a target nucleic acid sequence in a sample, the target nucleic acid sequence comprising a first DNA strand and optionally the complementary strand thereof, said method comprising: (a) adding a detection primer to the nucleic acid, wherein the detection primer binds to the first DNA strand at a DNA sequence that comprises the mutation site; (b) extending the detection primer to form second DNA strands that are complementary to the first DNA strand; (c) adding an amplification primer to the nucleic acid, wherein the amplification primer binds to the second DNA strand and/or to the complementary strand, at a position away from the mutation site; (d) extending the amplification primer to form third DNA strands that are complementary to the second DNA strands, and/or additional copies of the first DNA strand; (e) annealing the DNA strands by complementary base pairing, to form nucleic acid duplexes, wherein if the two strands of the duplex have a mismatched residue at the mutation site, the duplex is a heteroduplex, and. wherein if the two strands of the duplex do not have a mismatched residue at the mutation site, the duplex is a homoduplex; and (d) detecting the presence of heteroduplexes and/or homoduplexes. | 2008-10-23 |
20080261201 | Methods and compounds to alter virus infection - The invention provides a method to identify an agent that alters parvovirus transduction of mammalian cells. Also provided is a method to enhance transgene expression in a mammalian cell, as well as a method to identify an agent that alters NADPH oxidase activity in parvovirus transduced mammalian cells. | 2008-10-23 |
20080261202 | Tagged Polyfunctional Reagents Capable of Reversibly Binding Target Substances in a pH-dependent Manner - Polyfunctional reagents are disclosed that are capable of reversibly binding to target substances, for example nucleic acid, proteins, polypeptides, cells, cell components, microorganisms or viruses, for use in purifying or otherwise manipulating them. The reagents comprise a tagging group for manipulating and/or detecting the target substance when bound to the polyfunctional reagent. The polyfunctional reagents work by binding the target substance at a first pH and then releasing it at a second pH, usually higher than the first. Examples of tagging groups include tagging group members of a specific binding pair which is capable of binding to a specific binding partner and/or a label. | 2008-10-23 |
20080261203 | Detection of Epstein-Barr Virus - The invention provides methods to detect EBV in biological samples using real-time PCR. Primers and probes for the detection of EBV are provided by the invention. | 2008-10-23 |
20080261204 | Polynucleotide Ligation Reactions - The method of the invention is useful in quantifying the absolute or relative number of unique molecules present in a sample after carrying out an analysis procedure on the sample, and comprises the steps of: (i) attaching a unique molecular tag to substantially all of the molecules in the sample; (ii) carrying out the analysis procedure using the molecules of the sample; and (iii) on the basis of the molecular tags determining the absolute or relative number of unique molecules present in the original sample which underwent the analysis procedure. | 2008-10-23 |
20080261205 | Method for the Simultaneous Determination of Blood Group and Platelet Antigen Genotypes - RBC and platelet (Plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated Abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents. Alternatively, RBC and Plt antigens can be screened by virtue of their associated single nucleotide polymorphisms (SNPs). We developed a multiplex PCR-oligonucleotide extension assay using the GenomeLab SNPStream platform to genotype blood for a plurality of blood group antigen-associated SNPs, including but not limited to: RhD (2), RhC/c, RhE/e, S/s, K/k, Kp | 2008-10-23 |
20080261206 | Oligonucleotide for Detection of a Microorganism, Diagnostic Kits and Methods for Detection of Microorganisms Using the Oligonucleotide - The present invention relates to a method so called Bacterial Digitalcode System (BaDis) that identifies microorganism by using bacterial-specific, genus-specific and species-specific oligonucleotides from a variety of samples or specimens for detection and differential diagnosis of microorganism. Particularly, the present invention relates to bacterial-specific, genus-specific and species-specific oligonucleotides designed by the target nucleotide sequences of 23S rDNA or ITS gene, polymerase chain reaction (hereinafter, referred to as “PCR”) kits using the oligonucleotides as a primer, the microarray containing the oligonucleotides as a probe, and methods for detecting microorganism by using the oligonucleotides. Therefore, the present invention can be applied to detect the presence of microorganism and diagnose differentially all microorganism such as pathogenic bacteria of infectious diseases, bacteria inducing food poisoning, bacteria contaminating biomedical products and environmental pollutants. | 2008-10-23 |
20080261207 | Method of Measuring Cancer Susceptibility - An individual's susceptibility to cancer is assessed based on the individual's cellular response to mutagenic agents such as radiation. The level of a growth-suppressing marker is measured before and after the individual's cells are exposed to the mutagenic agent. The individual's susceptibility to cancer as a result of the mutagenic agent is correlated with the degree to which the growth-suppressing marker is induced by exposure to the agent. A method is also disclosed for assessing cancer prophylaxis effects of compounds, such as vitamins or food extracts, in individuals. Cells from an individual are incubated with at least one compound in vitro, or the compound is directly administered to the individual, after which some of the incubated cells, as well as non-incubated cells, are exposed to a mutagenic agent such as ionizing radiation. The level of the growth-suppressing marker in the cells incubated with the compound and exposed to the mutagenic agent is then compared with the level in the non-incubated cells exposed to the agent. The cancer prophylaxis effects of the compound are correlated with a higher level of the marker in the incubated cells. | 2008-10-23 |
20080261208 | 2'-Nitrobenzyl-Modified Ribonucleotides - This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided. | 2008-10-23 |
20080261209 | Electrophoretic Separation Method for Analyzing Gene Expression - The following invention relates to an improved method of quantitative or qualitative analysis of gene expression of a biological material. | 2008-10-23 |
20080261210 | Assay Method - The invention provides a cassette-based automated assay for homocysteine. | 2008-10-23 |
20080261211 | Variants in complement regulatory genes predict age-related macular degeneration - Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided. | 2008-10-23 |
20080261212 | Method of Diagnosis/Prognosis of Human Chronic Lymphocytic Leukemia Comprising the Profiling of Lpl/Adam Genes - The present invention provides methods of diagnosis and prognosis of human chronic lymphocytic leukemia (CLL) in a patient in need thereof and methods to determine IgVH mutational status. The methods of the present invention involve measuring the expression profile of two known genes: LPL and ADAM29; and comparing the ratio of their expression to diagnose the presence of CLL or to prognose the likelihood of developing CLL or the symptoms consistent with CLL. | 2008-10-23 |
20080261213 | Assay - The invention relates to a method for screening for pre-eclampsia in a mammal, such as a human, by determining the amount and quality of foetal 2,3 bisphosphoglycerate mutase (2,3 BPGM) present. Reagents and kits for carrying out the method are also provided. | 2008-10-23 |
20080261214 | DNA polymorphisms in sterol-regulator-element binding proteins - The invention relates to DNA polymorphisms in sterol regulator element binding proteins (SREBP) that are characteristic of a higher risk of genetic diseases in humans such as hyperchlolesterolemia. The corresponding polymorphisms, especially the polymorphisms on SREBP-1 and SREBP-2 are frequently observed in Alzheimer patients (SREBP-2). They are also characterized by a specific behavior in the therapy of HIV patients with proteas inhibitors and appear to have an influence on the mortality. | 2008-10-23 |
20080261215 | Method for Evaluating the Allergen Sensitivity of an Individual - The present invention discloses a method for evaluating the allergen sensitivity of an individual and/or the clinical efficacy of an allergen immunotherapy comprising the steps: providing at least two samples selected from the group consisting of blood or fractions thereof, connective tissue, nasal, bronchial, skin or gut biopsy material from an individual subjected or intended to be subjected to an immunotherapy with at least one pure allergen or derivative thereof, wherein the samples contain cells capable of releasing mediators in response to said allergen, contacting said sample with said allergen or derivative thereof, and determining the amounts of mediators released from said sample and evaluating the allergen sensitivity of the individual prior to therapy and/or the clinical efficacy of the immunotherapy by comparing said amounts. | 2008-10-23 |
20080261216 | HERV Group II Viruses In Lymphoma And Cancer - The present invention relates to compositions and methods for cancer diagnosis and therapy, including but not limited to, cancer markers. In particular, the present invention relates to HERV-K(HML-2) target titers as diagnostic markers, and HERV-K(HML-2) therapeutic targets for HIV-related cancers, and other cancers. | 2008-10-23 |
20080261217 | Methylation Profile of Cancer - The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods of identifying methylation patterns in genes associated with specific cancers. | 2008-10-23 |
20080261218 | Detection of Biomarkers for Neuropsychiatric Disorders - Systems and methods provide a comprehensive high-throughput approach toward the sequential identification, prioritization, verification, and validation of etiologic factors in neuropsychiatric disorders, some of which can also be utilized as biomarkers for these illnesses. The systems and methods determine patterns of gene expression in various tissues from various samples under various experimental and non-experimental conditions, and uses the differences and similarities between the gene expression profiles observed under these conditions to delineate distinct gene expression profiles of risk and treatment of neuropsychiatric disorders. | 2008-10-23 |
20080261219 | Polynucleotide Primers - A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77. | 2008-10-23 |
20080261220 | Nucleic Acid Detection Assays - The present invention relates to novel methods of producing oligonucleotides. In particular, the present invention provides an efficient, safe, and automated process for the production of large quantities of oligonucleotides. | 2008-10-23 |
20080261221 | AUTOMATED VNTR GENOTYPING METHOD - The invention provides an automated VNTR genotyping method using multiple variable-number tandem repeats (VNTRs) loci based on mycobacterial interspersed repetitive units (MIRU) undergoing multiplex PGR and high throughput MEGABACE® capillary electrophoresis system. The method uses fluorescent dyes of 6-carboxytetramethylrhodamine(TAMRA), 6-carboxy fluorescein (FAM) and 6-carboxy-2′, 4, 4′, 5′, 7, 7′-hexachlorofluorescein (HEX) labeling PGR primers. The method results in an efficient VNTR genotyping with low cost, less labor-requirement and less reaction time. The method is applicable in organism analyses by VNTR genotyping, such as microorganisms, parasites, animals or plants. | 2008-10-23 |
20080261222 | Rapid and comprehensive identification of prokaryotic organisms - An improved method for rapid identification of microorganisms is disclosed, along with sequences of PCR primers optimized for this purpose. The primers are designed based on information analysis of sequences from a large number of organism to amplify certain segments of genomic DNA whose sequences are unique among different organisms. The PCR products are compared with a DNA sequence database to obtain the identity of the microorganisms. This approach provides an accurate and fast identification and taxonomic assignment of microbial species. | 2008-10-23 |
20080261223 | ARL-1 Specific Antibodies - This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides methods of making and methods of using said antibodies. | 2008-10-23 |
20080261224 | PGC-1Beta, A Novel PGC-1 Homologue and Uses Therefor - The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1β gene has been introduced or disrupted. The invention still further provides isolated PGC-1β proteins, fusion proteins, antigenic peptides and anti-PGC-1β antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided. | 2008-10-23 |
20080261225 | METHOD AND KIT FOR DETECTING A TARGET PROTEIN USING A DNA APTAMER - A method and a kit for detecting a target protein in a sample with a signal amplification strategy are provided. The signal amplification strategy is established for the aptamer-based molecular recognition of a target protein with concomitant release of single-stranded DNA (G-DNA), which binds complementarily to a single-stranded RNA comprising a fluorophore and a quencher (“F-RNA-Q”). The fluorescence-quenched RNA is then degraded by RNase H to result in a fluorescence signal, and the undamaged G-DNA is recycled to yield fluorescence amplification. | 2008-10-23 |
20080261226 | Biomarkers of neurodegenerative disease - The present invention provides biomarkers and diagnostic methods employing such biomarkers based on the discovery of genes that have a two-fold or greater difference in gene expression in the spinal cord of a pre-symptomatic mouse model of amyotrophic lateral sclerosis. Such biomarkers and diagnostic methods are useful for early detection of neural cell injury and death in acute and degenerative disease. | 2008-10-23 |
20080261227 | Kinetic Pcr Assay for Quantification of Gene Amplification on Chromosome 17 - Provided is a kinetic PCR (“kPCR”) assay for determining gene copy number of a target gene located on chromosome 17. The kPCR assay uses the MMP-28 gene located at the 17q11.2-17q12 loci as a control and thus, is capable of detecting gene copy number of any gene on chromosome 17 in both singleplex and multiplex format without the need for a standard curve. The kPCR assay is useful for determining the gene copy number of the HER2/neu gene located at loci 17q12-17q21.32, which is a requirement for determining if a breast cancer patient is a candidate for anti-HER2/neu gene therapy. | 2008-10-23 |
20080261228 | PCA3 Messenger RNA Species in Benign and Malignant Prostate Tissues - This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer. | 2008-10-23 |
20080261229 | SIMULTANEOUS RAPID DETECTION OF MICROBES - The invention includes a method of simultaneously detecting the presence or absence of more than one microbe class (e.g., bacteria, yeast, and mold) in a sample. The method can include the step of applying a sample suspected of containing more than one microbe class to a growth medium, optionally fragmenting the sample, associating the sample with a labeling agent, and simultaneously detecting the presence or absence of each microbe class by detection of the labeling agent. | 2008-10-23 |
20080261230 | FERMENTIVE PRODUCTION OF ISOBUTANOL USING HIGHLY ACTIVE KETOL-ACID REDUCTOISOMERASE ENZYMES - Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol. | 2008-10-23 |
20080261231 | DIABETES GENE - The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the invention relates to germline mutations in the AGT gene and their use in the diagnosis of predisposition to diabetes. The invention also relates to the prophylaxis and/or therapy of diabetes associated with a mutation in the AGT gene. The invention further relates to the screening of drugs for diabetes therapy. Finally, the invention relates to the screening of the AGT gene for mutations, which are useful for diagnosing the predisposition to diabetes. | 2008-10-23 |
20080261232 | Use of Precursors of Enkephalins and/or Their Fragments in Medical Diagnostics - The invention relates to the diagnosis of disease based on the presence of biochemical components in human or animal body fluids, tissues and/or biomaterials. More specifically the invention relates to the use of precursors of enkephalins and/or its fragments isolated from body fluids, tissues or other biomaterials as a marker peptide for detection of a number of diseases/disorders including diseases/disorders of the central nervous system, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, Huntington's disease, ischemia including myocardiac ishcemica, schizophrenia, disease/disorders of the immune system, diseases/conditions of pain, chronic pain, migraine, tension type headache, tumor diseases/cancer including lymphoblastic leukaemia, malignant brain tumors, adenomas, in particular human pituitary adenomas, disorders of the blood brain barrier, multiple sclerosis, inflammation, chronic arthritis, infectious diseases, bacterial and viral infections, in particular infections of Gram-positive bacteria, borna diseases virus infections, peritonitis, intoxication, AIDS, stress, trauma comprising head trauma, infarction, in particular cerebral infarction, heart and cardiovascular diseases including coronary heart disease, bone and skin disorders, malaria chronic/obstructive pulmonary disease and cerebral damage. The invention further provides antibodies that bind to proenkephalin and its fragments. In accordance with the invention, a kit useful for the above mentioned diagnosis is also provided. | 2008-10-23 |
20080261233 | Assessment of Biological Activity of Hepatocyte Growth Factor (Hgf) - In the present invention the methods for recognition of biologically active hepatocyte growth factor efficient for using in therapeutic components are presented. The biological activity can be determined using: i) an in vitro model of restitution of damaged cells, and/or ii) affinity measurements or epitope mapping using SPR, with the C-met receptor, anti-HGF antibodies or polysaccharides such as dextran, and/or iii) an animal model of hair growth rates. By these methods the activity of HGF in body secretions can be evaluated as well. | 2008-10-23 |
20080261234 | Peptides and their use in assays for cardiovascular disease - A peptide having affinity for oxidised low density lipoprotein, in cyclised or multimeric form is useful in an enzyme immunosolvent assay, to detect oxLDL which is a marker of coronary heart disease. | 2008-10-23 |
20080261235 | Novel Green and Orange Fluorescent Labels and Their Uses - The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulpbonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein. | 2008-10-23 |
20080261236 | FGF21 upregulates expression of GLUT-1 in a beta Klotho-dependent manner - A method is provided to identify a modulator of βKlotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of βKlotho and an FGFR. | 2008-10-23 |
20080261237 | Inositol-Phosphate Derivatives and Method of Detecting Inositol-1-Phosphate - The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. | 2008-10-23 |
20080261238 | Method for Differentiation of Factor XIII Deficiency States in Relation to Fibrinogen Deficiency States Using Thrombelastographic Techniques - The invention relates to a method for determining a factor XIII deficiency, a method for determining a fibrinogen deficiency, and a method for differentiating between a factor XIII deficiency and a fibrinogen deficiency by means of thrombelastographic techniques. On the basis of the evaluation of the thrombelastographic parameters, a rapid and a selective substitution of factor XIII and/or of fibrinogen in deficiency states is possible. | 2008-10-23 |
20080261239 | DETECTING MOLECULAR INTERACTIONS - The present disclosure features a variety of compositions, kits, and methods that are useful for, inter alia, detecting and/or analyzing an interaction between two molecules, a target molecule and a target-specific binding agent which can be, e.g., proteins, nucleic acids, saccharides or polysaccharides, small molecules, or combinations of any of the foregoing. The compositions, kits, and methods can also be used, e.g., to detect the presence or absence of an enzymatic activity (e.g., a kinase activity, a protease activity, or a phosphatase activity) in a sample; to identify a compound that modulates an interaction between two molecules; or to identify compounds that modulate the activity of an enzyme. | 2008-10-23 |
20080261240 | METHOD - A method for attenuating a microorganism which comprises inhibiting in the microorganism a metabolic pathway essential for viability, by promoting use of the substrate of the pathway in a different metabolic pathway which is non-essential to the microorganism whereby the substrate is unavailable to the essential pathway and the micro organism is attenuated. | 2008-10-23 |
20080261241 | Targeted ubiquitination of proteins and screening methods using a new class of ubiquitin ligase proteins - Members of the IpaH superfamily constitute a novel class of E3 ubiquitin ligases which are useful for engineering products which modulate trafficking and destruction of target proteins inside a cell and useful targets for identifying new antimicrobial molecules which modulate, especially inhibit, E3 ligases. | 2008-10-23 |
20080261242 | Highly Sensitive System and Methods for Analysis of Troponin - The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin. | 2008-10-23 |
20080261243 | Detection of Elevated Levels of Her-2/Neu Protein on Circulating Cancer Cells and Treatment - The expression of Her-2/neu protein on circulating cancer cells in a blood sample is detected by isolating the cancer cells from the blood sample and then performing on the isolated cancer cells a sensitive Her-2/neu immunoassay. A positive result indicates the expression of Her-2/neu on cancer cells in the blood sample. This method can be used to identify cancer patients who are likely to benefit from treatment with an anticancer agent that targets Her-2/neu, such as trastuzumab (HERCEPTIN). | 2008-10-23 |
20080261244 | Compositions And Methods For Treating And Diagnosing Pancreatic Cancer - The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors. | 2008-10-23 |
20080261245 | ANTIBODIES, INCLUDING FV MOLECULES, AND IMMUNOCONJUGATES HAVING HIGH BINDING AFFINITY FOR MESOTHELIN AND METHODS FOR THEIR USE - Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin. | 2008-10-23 |
20080261246 | TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER AND POSTOPERATIVE MARKER FOR MINIMAL RESIDUAL DISEASE OR RECURRENT DISEASE IN PATIENTS WITH A PRIOR HISTORY OF CANCER - The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent cancer after being treated for the primary cancer by determining a parameter representing the post-operative TIMP-1 concentration in body fluid samples from the individual. In addition, the invention describes the additive effect of combined post-operative measurements of plasma TIMP-1 and serum CEA. | 2008-10-23 |
20080261247 | Method of detecting red cell antigen-antibody reactions - A process for the detection of antibodies in a test sample by carrying out the following steps:
| 2008-10-23 |
20080261248 | Method of detecting red cell antigen-antibody reactions - A process for the detection of antibodies in a test sample by carrying out the following steps:
| 2008-10-23 |
20080261249 | Detecting and Quantifying Host Cell Proteins in Recombinant Protein Products - A single-step immunoassay method, kit, and reagents for detecting and quantifying contaminant host cell proteins in a recombinant protein sample are described. The method includes the step of adding to immobilized medium comprising a capture reagent including anti-host cell protein antibodies, both the recombinant protein sample and a detection reagent comprising anti-host cell protein antibodies and a detectable moeity. The recombinant protein sample and two reagents are added simultaneously. This single-step format provides greater interaction between the capture antibody, the contaminant host cell proteins that may be present in the recombinant protein sample, and the detection antibody. By providing the opportunity for both antibodies and HCPs to interact at the same time, the one step format allows the formation of the “capture antibody-HCP-detection antibody” complex with all possible HCPs present. Thus, the HCP assay sensitivity is significantly improved, and the possibility of a false negative is significantly reduced. In addition, the one step format shortens the assay turnaround time and provides a convenient tool for measuring the HCP in the product during the course of the entire purification procedure. Quality control of the process is increased and the protein purification efficiency during process development can be measured. | 2008-10-23 |
20080261250 | Methods for Assessing the Risk for Development of Cardiovascular Disease - The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation product. Measuring the quantity of one or more HDL oxidation products present in the blood is useful in evaluating risk for developing or evaluating the severity of a disease or evaluating response to treatment for such a disease as, for instance, cardiovascular disease. | 2008-10-23 |
20080261251 | Monoclonal Antibodies, Hybridomas, Improved Method for Determining the Protein Ptx3 and Kit for Said Determination - Method for determining the level of PTX3 protein in a sample of a biological fluid; hybridoma capable of producing a rat anti-PTX3 monoclonal antibody where said hybridoma is selected from the group comprising MNB10 and Pen-3; specific anti-PTX3 rat monoclonal antibody selected from the monoclonal antibodies produced by the hybridomas MNB10 and Pen-3; kit for determining the level of PTX3 protein in a biological fluid wherein the said kit includes a rat anti-PTX3 monoclonal antibody. | 2008-10-23 |
20080261252 | Soluble Interleukin-1 Receptor Accessory Molecule - The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists. | 2008-10-23 |
20080261253 | Methods and kits for the diagnosis of galactosemia - Provided are methods for the detection and diagnosis of galactosemia. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of galactosemia. At least two new biomarkers for galactosemia are thus disclosed, Eotaxin and MCP-1. Altogether the concentrations these markers, individually, or in combinations with any of Alpha-2 Macroglobulin, Apolipoprotein H, Cancer Antigen 125, Leptin, TNF RII, Alpha-Fetoprotein, IgM, MIP-1 alpha, Ferritin, and IgE provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from galactosemia. Kits containing reagents to assist in the analysis of fluid samples are also described. | 2008-10-23 |
20080261254 | Procedure for the determination of the reaction lag phase in an analyte-dependent reaction - The invention is in the field of analytical technique and relates to an improved procedure for determining the concentration or activity of an analyte, an analyte-dependent detection reaction being set in motion and the reaction kinetics determined being evaluated. The procedure makes possible an individual determination of the lag phase of the reaction kinetics for each measurement. | 2008-10-23 |
20080261255 | Proteins, Sensors, and Methods of Characterizing Analytes Using the Same - A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used in methods for characterizing samples and may also be used in sensors. | 2008-10-23 |
20080261256 | Methods of assaying receptor activity and constructs useful in such methods - Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described. | 2008-10-23 |
20080261257 | Fluorescent Proteins and Related Methods and Compounds - The invention includes fusion polypeptides including a first fluorescent protein, e.g., a FRET donor protein, a second fluorescent protein, e.g., a FRET acceptor protein, and, linked to at least one of the fluorescent (e.g., FRET donor or FRET acceptor) proteins, an Fc-region of an immunoglobulin. The polypeptide can be immobilized with respect to a surface via the Fc-region even in the absence of antibodies to either the FRET donor protein or FRET acceptor protein, and can be used as a calibration standard for fluorescence resonance energy transfer includes a polypeptide. | 2008-10-23 |
20080261258 | Immune Cell Biosensors and Methods of Using Same - The present invention relates to immunological cells that are useful in detecting changes in physiological states, which provide for methods of diagnosing diseases or monitoring the course of patient therapy. Also provided are arrays of antigen presenting cell-specific markers for detecting changes in physiological states, and methods of detecting such changes. | 2008-10-23 |
20080261259 | Culture Media For Expansion and Differentiation of Epidermal Cells and Uses Thereof For In Vitro Growth of Hair Follicles - The invention is directed to a chemically defined animal cell culture media, and methods for preparing such a medium, wherein the media are suitable for culturing epidermal cells, preferably human epidermal cells, including cells of the hair follicle. The invention further provides for methods of culturing epidermal cells, hair follicles, and skin explants in the media as well as uses of the cell cultures and explant cultures in screening assays. | 2008-10-23 |
20080261260 | USE OF GELSOLIN TO TREAT INFECTIONS - The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression. | 2008-10-23 |
20080261261 | System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma - A system/analyzer-unit and method/platform—using information obtained from at least one, adapted for a plurality of, magnetoelastic sensor elements in contact with one or more samples comprising blood from a patient—for automatically quantifying one or more parameters of the patient's blood. Information obtained from emissions measured from each of the sensor elements is uniquely processed to determine a quantification about the patient's blood, such as, quantifying platelet aggregation to determine platelet contribution toward clot formation; quantifying fibrin network contribution toward clot formation; quantifying platelet-fibrin clot interactions; quantifying kinetics of thrombin clot generation; quantifying platelet-fibrin clot strength; and so on. Structural aspects of the analyzer-unit include: a cartridge having at least one bay within which a sensor element is positioned; each bay in fluid communication with both (a) an entry port for injecting a first blood sample composed of blood taken from the patient (human or other mammal), and (b) a gas vent through which air displaced by injecting the first blood sample into the bay. | 2008-10-23 |
20080261262 | Lysis/Resealing Process and Device for Incorporating an Active Ingredient, in Particular Asparaginase or Inositol Hexaphosphate, in Erythrocytes - Lysis/resealing process for preparing erythrocytes which contain an active ingredient (e.g. aspariginase or inositol hexaphosphate), the process comprising the following steps: (1) placing a globular concentrate in suspension in an isotonic solution having a haematocrit level which is equal to or greater than 65%, with refrigeration at from +1 to +8° C., (2) measuring the osmotic fragility based on a sample of erythrocytes from that same globular concentrate, preferably on a sample of the suspension obtained in step (1), (3) lysis and internalisation procedure of the active ingredient, inside the same chamber, at a temperature which is constantly maintained at from +1 to +8° C., comprising allowing the erythrocyte suspension having a haematocrit level which is equal to or greater than 65% and a hypotonic lysis solution which is refrigerated at from +1 to +8° C. to circulate in a dialysis cartridge; the lysis parameters being adjusted in accordance with the osmotic fragility previously measured; and (4) resealing procedure carried out in a second chamber at a temperature of from +30 to +40° C. by means of a hypertonic solution. | 2008-10-23 |
20080261263 | In Vitro Evaluation of Micro-Organisms and Their Antimicrobial Agent Susceptibilities - A method of identifying a micro-organism and determining the susceptibility of the micro-organism to an antimicrobial agent by inserting a sample of the micro-organism in a primary culture container and allowing the micro-organism to multiply. The primary culture is then divided into a plurality of secondary cultures and the metabolic volatile or semi-volatile compounds (VCs) in the headspace above the cultures are analysed by SIFT-MS to ascertain whether micro-organisms exist in the culture and determine the type of micro-organism. The secondary cultures are then divided into a number of tertiary cultures and an antimicrobial agent is introduced whereupon the VCs in the headspace above the tertiary cultures are analysed by SIFT-MS to determine the susceptibility of the micro-organism to the antimicrobial agent at various concentrations of the antimicrobial agent. | 2008-10-23 |
20080261264 | Culture Medium for Detecting of Clostridium Perfringens - The invention relates to a culture medium for the detection of | 2008-10-23 |
20080261265 | Histological staining composition and methods related thereto - Embodiments of the invention relate to a method for histological staining, the method comprises immersing a tissue sample in a staining solution sufficient to impregnate the tissue sample, dehydrating the tissue sample, embedding the tissue sample, cutting the tissue sample, developing the tissue sample, fixing the tissue sample and mounting the tissue sample. The staining solution comprises about 2.0×10 | 2008-10-23 |
20080261266 | METHODS AND COMPOSITIONS FOR A MICROEMULSION-BASED TISSUE TREATMENT - The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of intermediary alcohol dehydration or alcohol rehydration compositions. | 2008-10-23 |
20080261267 | Cellulases from Rumen - The invention provides polypeptides coding for new cellulases from rumen, particularly from rumen ecosystem. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding the polypeptides of the invention, vectors and host cells containing said nucleic acids, a method for producing the polypeptides and the use of the polypeptides according to the present invention for various industrial purposes and medical treatments. | 2008-10-23 |
20080261268 | 5-Substituted Hydantoin Racemase, Dna Encoding the Same, Recombinant Dna, Transformed Cell, and Process for Production of Optically Active N-Carbamylamino Acid or Optically Active Amino Acid - Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin racemase isolated and purified from | 2008-10-23 |
20080261269 | ALLELES OF THE OXYR GENE FROM CORYNEFORM BACTERIA - The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles. | 2008-10-23 |
20080261270 | Soluble ErbB3 Receptor Isoforms - The present invention discloses a system and method using isoforms of the human ErbB3 receptor as negative regulators of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses a system and method of one such isoform, p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to ErbB2/3 heterodimers on the cell surface of breast carcinoma cells. The present invention also uses p85-sErbB3 to inhibit heregulin-induced phosphorylation of ErbB2, ErbB3, and ErbB4 in cells and uses p85-sErbB3 as a negative regulator of heregulin-stimulated signal transduction and as a block for cell growth. The present invention is also directed to nucleic acids and expression vectors encoding p85-sErbB3, host cells harboring such expression vectors, and methods of preparing the protein. The present invention discloses a system and method of therapeutic applications in human malignancies associated with heregulin-mediated cell growth such as breast and prostate cancer. | 2008-10-23 |
20080261271 | EXPRESSION OF HIV POLYPEPTIDES AND PRODUCTION OF VIRUS-LIKE PARTICLES - The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered. | 2008-10-23 |
20080261272 | FUNGAL CELL WALL SYNTHESIS GENE - A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved. | 2008-10-23 |
20080261273 | PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITORS - The present invention relates to processes for producing compounds by using a protein derived from a microorganism belonging to the genus | 2008-10-23 |
20080261274 | Restoration of Cholesterol Independence and Its Use as a Selectable Marker in Ns0 Cell Culture - Gene complementation is used to restore cholesterol independence in NS lineage murine myeloma cells, such as NSO and NS 1, yielding a selectable system for recombinant production of polynucleotides and polypeptides. | 2008-10-23 |
20080261275 | Cdna Production from Cells After Laser Microdissection - The present invention provides a new procedure for the synthesis of CDNA from single cells after microdissection. It has the advantage that it is cost-efficient and can be carried out quickly with only few steps, even by less skilled laboratory employees. For the first time, the time-consuming and risky step of RNA isolation is omitted during cDNA synthesis from single cells by performing lysis and cDNA synthesis in the same reaction tube and in one buffer solution, which provides reliable and contamination-free results. The buffer is composed of NP40, carrier-RNA and Super RNAsin, as well as dNTPs and cDNA synthesis primers. | 2008-10-23 |
20080261276 | Micro-Fluidic Device Based Upon Active Matrix Principles - A micro-fluidic device ( | 2008-10-23 |
20080261277 | pRNA chimera - A circularly permuted chimeric pRNA molecule carrying a stabilized biologically active RNA, such as a ribozyme. | 2008-10-23 |
20080261278 | METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA BELONGING TO THE GENUS ESCHERICHIA - There is provided a method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine using a bacterium belonging to the genus | 2008-10-23 |
20080261279 | METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA BELONGING TO THE GENUS ESCHERICHIA - A method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine is provided using | 2008-10-23 |
20080261280 | Manipulation of Genes of the Mevalonate and Isoprenoid Pathways to Create Novel Traits in Transgenic Organisms - Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants and microalgae, and (3) create a novel selection system and/or targeting sites for mediating the insertion of genetic material into plant and microalgae plastids. The specific polynucleotides to be used, solely or in any combination thereof, are publicly available from GeneBank and contain open reading frames having sequences that upon expression will produce active proteins with the following enzyme activities: (a) acetoacetyl CoA thiolase (EC 2.3.1.9), (b) 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase (EC 4.1.3.5), (c) HMG-CoA reductase (EC 1.1.1.34), (d) mevalonate kinase (EC 2.7.1.36), (e) phosphomevalonate kinase (EC 2.7.4.2), (f) mevalonate diphosphate decarboxylase (EC 4.1.1.33), (g) isopentenyl diphosphate (IPP) isomerase (EC 5.3.3.2), and (h) phytoene synthase (EC 2.5.1.32). | 2008-10-23 |
20080261281 | Novel Carbonyl Reductase, Gene Thereof and Method of Using the Same - The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus | 2008-10-23 |
20080261282 | Fermentation Process for Preparing Coenzyme Q10 by the Recombinant Agrobacterium tumefaciens - The present invention relates to a transformed | 2008-10-23 |
20080261283 | Biooxidation capabilities of Candida sp - A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing | 2008-10-23 |