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42nd week of 2012 patent applcation highlights part 45
Patent application numberTitlePublished
20120264786USE OF THIAZOLIDINEDIONES FOR THE PARTIAL INHIBITION OF ANDROGEN BINDING TO AROMATASE - A method for the treatment or prophylaxis of a disorder, wherein the disorder is affected by estrogen, comprising partially inhibiting aromatase activity or interfering with the binding of androgen to aromatase by administering a therapeutically effective amount of a thiazolidinedione to the patient. The use of rosiglitazone or pioglitazone to partially inhibit the binding of androgen to aromatase by at least 20% is preferred.2012-10-18
20120264787Respiratory Disease Treatment - There is provided a pharmaceutical composition that is adapted for pulmonary administration by inhalation, which composition comprises a glitazone, such as pioglitazone or rosiglitazone, and one or more pharmaceutically acceptable carriers and/or excipients, and wherein the glitazone content of the composition consists of at least 95% by weight of the 5R enantiomer and less than 5% by weight of the 5S enantiomer. There is also provided a use and kit.2012-10-18
20120264788ANIMAL PARASITE-CONTROL METHOD USING INSECT GROWTH REGULATORS - Methods and formulations for treating animal ectoparasites, effective against parasites such as fleas and ticks are provided. The methods comprise topically co-administering a non-mobile insect growth regulator and a mobile insect growth regulator to the animal. Parasiticidal formulations for treating animal ectoparasites are also provided, which can be safe to use and avoid the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of two insect growth regulators, a non-mobile insect growth regulator and a mobile insect growth regulator. The topical formulation can be packaged with the two insect growth regulators together or packaged to prevent mixing of the two insect growth regulators prior to administering the topical insecticide formulation to the animal.2012-10-18
20120264789POLYMORPHS OF SORAFENIB ACID ADDITION SALTS - The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib.2012-10-18
20120264790ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS - The present invention relates to compounds of the formula I,2012-10-18
20120264791FATTY ACID NIACIN CONJUGATES AND THEIR USES - The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate.2012-10-18
20120264792FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES - A compound of formula (II)2012-10-18
20120264793Pharmaceutical Use of 2',2-Bis-Thiazole Non-Nucleoside Compounds as Hepatitis C Virus Inhibitor - The present invention discloses the pharmaceutical use of a 2′,2-bis-thiazole non-nucleoside compound of formula I as an inhibitor of hepatitis C virus (HCV). The 2′,2-bis-thiazole non-nucleoside compound can inhibit the replication of HCV, and thus has an anti-HCV activity and is useful for treating hepatitis C.2012-10-18
20120264794Method for Preparing Largazole Analogs and Uses Thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.2012-10-18
20120264795COMBINATION THERAPY WITH PARP INHIBITORS - The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARD inhibitors in combination with temozolomide (TMZ).2012-10-18
20120264796METHODS FOR MODULATING CIRCADIAN RHYTHMS - This disclosure described the role of AMPK in circadian rhythms and methods of screening for agents that modulate such rhythms, compositions that are useful for modulating such rhythms and uses thereof.2012-10-18
20120264797CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING METABOLIC DISORDERS, INCLUDING OBESITY AND DIABETES - The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, hepatic disorders, and/or cardiometabolic disorders.2012-10-18
20120264798PRODRUGS OF INHIBITORS OF PLASMA KALLIKREIN - This invention provides new pharmaceutically useful compounds that are prodrugs of inhibitors of plasma kallikrein and methods and compositions for preventing or treating plasma kallikrein dependent diseases or conditions, such as diabetic macular edema or hemorrhagic stroke, by administering prodrugs of the formula:2012-10-18
20120264799INDANE-AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS - The present invention relates to indane-amine derivatives, to processes for the preparation thereof, to medicaments comprising them as well as to their use for the preparation of a medicament for the treatment of 5HT7 receptor mediated diseases or conditions.2012-10-18
20120264800KINASE INHIBITORS AND METHOD OF TREATING CANCER - The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof:2012-10-18
201202648015-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS - Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38α, and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.2012-10-18
20120264802PHOTOSENSITIZERS FOR TARGETED PHOTODYNAMIC THERAPY - The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.2012-10-18
20120264803METHOD FOR PREDICTING THERAPEUTIC EFFECTS OF CHEMOTHERAPY ON HEPATOCELLULAR CARCINOMA PATIENTS - The present invention provides a method for predicting therapeutic effects of chemotherapy on hepatocellular carcinoma patients who have been treated with transarterial embolization and an antitumor agent for treating cancer patients who have been predicted to have a high probability of obtaining sufficient therapeutic effects from such chemotherapy. The present invention also provides a method for predicting therapeutic effects of chemotherapy on hepatocellular carcinoma patients who have been treated with transarterial embolization using the expression level of PDGF-BB or IL-8 as an indicator and an antitumor agent for treating cancer patients who have been predicted to have a high probability of obtaining therapeutic effects by such prediction method.2012-10-18
20120264804T TYPE CALCIUM CHANNEL BLOCKERS AND THE TREATMENT OF DISEASES - The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor blocks a splice variant of an α1H isoform of T type calcium channels.2012-10-18
20120264805MEDICAMENT FOR THE TREATMENT AND PREVENTION OF LIVER FAILURE - Small inhibitory RNA (siRNA) molecules, which e.g. are purified and/or isolated, as an active in a medicament, which siRNA molecules are inhibitory RNA molecules that through RNA interference (RNAi) reduce or prevent expression of the p53 upregulated modulator of apoptosis (PUMA). The siRNA molecules can be administered as a medicament to a patient suffering from an impaired liver function or from liver damage for the treatment of a functionally impaired liver, for delaying a deterioration of liver function and/or for prevention of liver failure, especially in patients who suffer from a critical impairment of damage to the liver, e.g. for delaying the complete failure of liver function.2012-10-18
20120264806OLIGOMERIC COMPOUNDS AND EXCIPIENTS - The present invention provides method of optimizing the efficacy and potency of antisense compounds. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.2012-10-18
20120264807METHOD FOR INTRODUCING SIRNA INTO CELLS BY PHOTOCHEMICAL INTERNALISATION - The present invention relates to a method for introducing an siRNA molecule into the cytosol of a cell, said method comprising i) contacting said cell with an siRNA molecule, a carrier and a photosensitising agent, and ii) irradiating the cell with light of a wavelength effective to activate the photosensitising agent, wherein said carrier comprises a cationic polyamine such as a lipopolyamine in a non-liposomal formulation, polyethyleneimine (PEI), a betacyclodextrin amine polymer, an amine group containing dendrimer, and a cationic peptide. Cells or a population of cells obtainable by the method, a composition containing an siRNA molecule and the carrier molecule, kits and therapeutic uses of the above are also provided.2012-10-18
20120264808METHODS AND COMPOSITIONS FOR MODULATING CALCIUM CHANNELS - The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) Cav1.3a calcium channels for research and therapeutic methods (e.g., treating dopaminergic diseases and conditions).2012-10-18
20120264809RNAi-Mediated Inhibition of Histamine Receptor H1-Related Conditions - RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy.2012-10-18
20120264810COMPOSITIONS AND METHODS FOR ENHANCING CELLULAR UPTAKE AND INTRACELLULAR DELIVERY OF LIPID PARTICLES - Compositions, methods and compounds useful for enhancing the uptake of a lipid particle b\ a cell are described In particular embodiments, the methods of the invention include contacting a cell with a lipid particle and a compound that binds a Na+/K+ ATPase to enhance uptake of the lipid particle b\ the cell Related compositions useful in practicing methods include lipid particles comprising a conjugated compound that enhances uptake of the lipid particles b\ the cell The methods and compositions are useful in delivering a therapeutic agent to a cell, e g for the treatment of a disease or disorder in a subject2012-10-18
20120264811Elongator Proteins and Use Thereof as DNA Demethylases - The invention provides DNA demethylases comprising Elp1, Elp2, Elp3, Elp4, Elp5 and/or Elp6. The invention also provides methods of modulating gene expression, for example, for the treatment of cancer or to modify the cellular transcription program (e.g., for regenerative medicine). Also provided are methods of identifying compounds that modulate the DNA demethylase activity of the DNA demethylases of the invention.2012-10-18
20120264812TREATMENT OF NUCLEAR RESPIRATORY FACTOR 1 (NRF1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO NRF1 - The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Nuclear Respiratory Factor 1 (NRF1), in particular, by targeting natural antisense polynucleotides of Nuclear Respiratory Factor 1 (NRF1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of NRF1.2012-10-18
20120264813siRNA Targeting Cyclin-dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CDKN1B.2012-10-18
20120264814Isolation, Cloning, Sequencing and Functional analysis of ss-casein promoter along with the regions of exon1, intron1 and exon2 using mammary gland derived cell line of Buffalo (Bubulus bubalis) - The present invention relates to a method of in vitro isolation of buffalo β-caesin promoter (buCSN2) along with the regions of exon1, intron1 and exon2 from the genomic DNA in vitro (2012-10-18
20120264815REVERSIBLE PLATELET INHIBITION - The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.2012-10-18
20120264816Sulfated Oxysterol and Oxysterol Sulfation by Hydroxysterol Sulfotransferase Promote Lipid Homeostasis and Liver Proliferation - Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.2012-10-18
20120264817SOLUBILIZED FORMULATION OF DOCETAXEL WITHOUT TWEEN 80 - Lyophilizates containing docetaxel and the use thereof in preparing concentrated liquid formulations, and ready to use formulations for injection, as well as such concentrates and ready to use formulations themselves are disclosed in which Tween surfactants are avoided so that hypersensitivity reactions to Tween surfactants can be avoided and docetaxel can be administered at higher doses and/or for longer periods of time and/or for additional treatment cycles.2012-10-18
20120264818Topical Compositions with Cannabis Extracts - Various topical compositions including heat-treating mature, dried, powdered Cannabis sativa flower and bud leaves in carriers are disclosed. Various methods for the treatment of pain and methicillin-resistant 2012-10-18
20120264819Therapeutic Uses of Urolithins - The subject invention is drawn to ellagitannin metabolites (e.g., urolithin) that find use in treating or preventing a neoplastic disease in a subject.2012-10-18
20120264820Synthetic Flavonoids and Pharmaceutical Compositions and Therapeutic Methods of Treatment of HIV infection and other pathologies - A compound, pharmaceutical composition and method for the treatment of mammals wherein the active therapeutic agent is a compound having the structure:2012-10-18
20120264821USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.2012-10-18
20120264822METHOD OF IMPROVING ANIMAL TISSUE QUALITY BY SUPPLEMENTING THE ANIMAL DIET WITH OLEIC ACID AND SELECTED TOCOLS - A novel method for improving the meat quality of an animal is provided. The method comprises feeding the animal a diet supplemented with oleic acid and selected tocols in amounts effective to improve the meat quality. The method may be practiced on non-ruminants and ruminants.2012-10-18
20120264823SUBSTITUTED HETEROARYL- AND ARYL-CYCLOPROPYLAMINE ACETAMIDES AND THEIR USE - The invention relates to compounds of Formula (I): (A′)2012-10-18
20120264824COMPOSITIONS AND METHODS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS - Methods and compositions are disclosed comprising ethyl eicosapentanoate for the treatment of non-alcoholic steatohepatitis (NASH).2012-10-18
20120264825Amino Acid Perhydrates, Process for Their Preparation and Uses thereof - The invention provides compounds which are -amino acid hydrogen peroxide solvates, wherein the side chain of the -amino acid has no basic nitrogen. A process for preparing the compounds and uses thereof are also described.2012-10-18
20120264826N-Acetyl Beta Alanine Methods of Use - Methods for increasing athletic performance, preventing paresthesia, increasing beta alanine absorption and cell membrane permeability through both passive diffusion and active transport, and increasing the half-life of beta alanine present in a blood stream in a human or animal are disclosed. Each method includes administering to the human or animal a pharmaceutically effective amount of N-Acetyl Beta Alanine or an N-Acetyl Beta Alanine composition.2012-10-18
20120264827SULFANYLAMIDE DERIVATIVES, USES THEREOF AND COMPOSITIONS COMPRISING THEM - The present invention concerns a family of sulfanilamide derivatives of formula (I) as anticonvulsant agents, where R is selected from optionally substituted C2012-10-18
20120264828POLYMORPHIC FORMS OF O-DESMETHYL-VENLAFAXINE SUCCINATE - The present invention discloses polymorphic forms of O-desmethyl-venlafaxine succinate and processes for the preparation thereof.2012-10-18
20120264829METHOD FOR ADMINISTERING AN NMDA RECEPTOR ANTAGONIST TO A SUBJECT - The invention provides methods for administering memantine to a subject. Memantine in an extended release form containing 22.5 to 30 mg memantine or a pharmaceutically acceptable salt is administered to a patient suffering from a neurological condition, such as Alzheimer's disease, Parkinson's disease or dementia. The extended release form achieves particular pharmacokinetic criteria such as change in plasma concentration of memantine over time and ratio of maximum memantine plasma concentration to mean memantine plasma concentration.2012-10-18
20120264830CHONDROITIN SULFATE-POLYCAPROLACTONE COPOLYMER, METHOD FOR PREPARING THE SAME AND APPLICATION THEREOF - A method for preparing a chondroitin sulfate-polycaprolactone copolymer includes subjecting a chondroitin sulfate component and a polycaprolactone polymer to an atom transfer radical polymerization reaction in the presence of a catalyst.2012-10-18
20120264831REBAUDIOSIDE-MOGROSIDE V BLENDS - A composition includes Mogroside V and a Rebaudioside component in a weight ratio ≧1:1 and ≦6:1, wherein the Rebaudioside component consists of one or more compounds selected from the group consisting of Rebaudioside A, Rebaudioside B and Rebaudioside D. A method of purifying a Luo Han Guo extract includes contacting the Luo Han Guo extract with activated carbon and a macroporous polymeric adsorbent resin, an ion exchange resin, or both. A composition includes a Luo Han Guo extract, wherein Mogroside V constitutes from 50 wt % to 75 wt % of the Luo Han Guo extract and the composition includes from 0 to 13 wt % in total relative to the Mogroside V of aromatic glycosides, and from 0 to 15 ppm of semi-volatile organic compounds relative to the Mogroside V.2012-10-18
20120264832Low Inflammatory Blended Oils - A low inflammatory oil composition and method for supplementing feed, nutrition and diet systems with omega-3 to omega-6 balanced oils comprised of a synergistic blend of at least two oils. The composition further comprises a synergistic blend of long chain omega-3 oil as a means to further increase the nutritional value. The composition further provides an effective increase in reducing inflammation for therapeutic, and pharmacological treatment in addition to general nutrition and diet systems.2012-10-18
20120264833PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE - Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.2012-10-18
20120264834DISODIUM SALTS, MONOHYDRATES, AND ETHANOL SOLVATES FOR DELIVERING ACTIVE AGENTS - The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.2012-10-18
20120264835METHOD FOR PRODUCING A SULFONATED POLYARYLETHER BLOCK COPOLYMER - A method of producing a sulfonated polyarylether block copolymer is provided. The method includes producing a sulfonated polyarylether block copolymer containing a hydrophobic segment having a structural unit represented by formula (5) and a hydrophilic segment having a structural unit having a sulfonic acid groups or derivative thereof incorporated into a structure represented by formula (6). A hydrophilic segment prepolymer having a sulfonic acid group in a potassium salt form and a hydrophobic segment prepolymer are block copolymerized. A proton conductor that includes the sulfonated polyarylether block copolymer is also provided.2012-10-18
20120264836EXPANDABLE THERMOPLASTIC NANOCOMPOSITE POLYMERIC COMPOSITIONS WITH AN IMPROVED THERMAL INSULATION CAPACITY - Nanocomposite compositions based on expandable thermoplastic polymers which comprise: a) a polymeric matrix produced by the polymerization of a base comprising one or more polymerizable monomers; b) 1-10% by weight, calculated with respect to the polymer (a), of an expanding agent englobed in the polymeric matrix; c) 0.004-15% by weight, calculated with respect to the polymer (a), of an athermanous filler comprising nano-scaled graphene plates with a thickness (orthogonal to the graphene sheet) not greater than 150 nm, an average dimension (length, width, or diameter) not greater than 10 micrometers and a surface area>50 m2/g.2012-10-18
20120264837Flameproof expandable polymerizates - The invention relates to flameproof expandable polymerizates, wherein a flame retardant system consisting of a combination of at least one phosphorus compound as a flame retardant and at least one sulfur compound as an additional flame retardant or synergist is contained.2012-10-18
20120264838INSULATING MATERIALS COMPRISING POLYSILAZANE, METHODS OF FORMING SUCH INSULATING MATERIALS, AND PRECURSOR FORMULATIONS COMPRISING POLYSILAZANE - Methods of forming an insulating material comprising combining a polysilazane, a cross-linking compound, and a gas-generating compound to form a reaction mixture, and curing the reaction mixture to form a modified polysilazane. The gas-generating compound may be water, an alcohol, an amine, or combinations thereof The cross-linking compound may be an isocyanate, an epoxy resin, or combinations thereof The insulating material may include a matrix comprising one of a reaction product of a polysilazane and an isocyanate and a reaction product of a polysilazane and an epoxy resin. The matrix also comprises a plurality of interconnected pores produced from one of reaction of the polysilazane and the isocyanate and from reaction of the polysilazane and the epoxy resin. A precursor formulation that comprises a polysilazane, a cross-linking compound, and a gas-generating compound is also disclosed.2012-10-18
20120264839FLAME RETARDANT BLENDS FOR FLEXIBLE POLYURETHANE FOAMS - A flame retardant blend comprises the following components: (a) at least one diester diol of a ring-brominated aromatic compound; (b) at least one alkylated triphenylphosphate; and (c) at least one hindered phenolic anti-oxidant in which the phenolic ring is substituted by at least one alkanoic alkyl ester group in which the alkanoic acid moiety has from about 2 to about 4 carbon atoms and the alkyl group has about 6 to about 16 carbon atoms. The proportions by weight of components (a) and (b) in the blend are in the range of about 30:70 to about 70:30 and the proportion by weight of component (c) to the sum of components (a) and (b) is in the range of about 0.1:100 to 1:100.2012-10-18
20120264840METHOD TO FORM A POLYURETHANE MATERIAL - A method to form a urethane material, the method comprises blending and reacting at least one isocyanate, at least one isocyanate reactive compound and a metallized polyhedral oligomeric silsesquioxane to provide said urethane material, the metallized polyhedral oligomeric silsesquioxane is a dimeric structure with general formula2012-10-18
20120264841PROCESS FOR PRODUCING RIGID POLYURETHANE FOAMS - A process for producing a rigid polyurethane foam by reacting an organic polyisocyanate with a polyol component containing a compound with at least two hydrogen atoms which are reactive toward isocyanate groups in the presence of a blowing agent, a catalyst, and optionally auxiliaries and additives, wherein the polyol component contains, by weight: 20 to 60 parts of a polyether alcohol having a functionality of 3.5 to 5.5 and a hydroxyl number of from 400 to 550 mg KOH/g; 1 to 20 parts of a polyether alcohol based on an aliphatic amine and having a functionality of 3.5 to 4.5 and a hydroxyl number of 450 to 900 mg KOH/g; 10 to 30 parts of a polyether alcohol and/or aromatic polyester alcohol having functionalities of 1.5 to 3 and a hydroxyl number of from 150 to 450 mg KOH/g; and optionally 1 to 5 parts of water.2012-10-18
20120264842PROCESS FOR PRODUCING RIGID POLYURETHANE FOAMS - A process for producing a rigid polyurethane foam by reacting (a) an organic polyisocyanate with (b) a compound having at least two hydrogen atoms that are reactive toward isocyanate groups, in the presence of (c) a blowing agent, (d) a catalyst and, optionally, (e) an auxiliary or additive. Component (b) contains: one or more high-functionality polyether alcohols having functionalities of 3.5 to 5.5 and a hydroxyl number of 400 to 550 mg KOH/g; one or more polyether alcohols based on aromatic and/or aliphatic amines and having functionalities of 3.5 to 4.5 and a hydroxyl number of 350 to 500 mg KOH/g; one or more polyether alcohols having functionalities of 2 to 4 and a hydroxyl number of 150 to 450 mg KOH/g; one or more low molecular weight chain extenders and/or crosslinkers having functionalities of 2 to 3 and a molecular weight of less than 400 g/mol; and optionally water.2012-10-18
20120264843COMPOSITION CONTAINING SPECIFIC CARBAMATE TYPE COMPOUNDS SUITABLE FOR PRODUCING POLYURETHANE FOAMS - Compositions suitable for producing polyurethane foams which include at least an isocyanate component, a polyol component, a catalyst catalyzing formation of a urethane or isocyanurate bond, and at least one compound containing at least one structural element of formula (I)2012-10-18
20120264844POLYPHOSPHONATE AND COPOLYPHOSPHONATE ADDITIVE MIXTURES - Disclosed are polymer compositions including polycarbonates, polyphosphonates, copoly(phosphonate carbonate)s, and organic salts and/or silicone containing compounds that exhibit a superior combination of properties compared to prior art.2012-10-18
20120264845RADIATION CURABLE INK COMPOSITION - A radiation curable ink composition has improved adhesion towards rigid recording media, good jetting behaviour and no or minimal health and safety risks. The radiation curable ink has a viscosity of 30 mPa·s, or less, at 50° C., has at least two monofunctional monomers, the two monofunctional monomers including a first monomer selected from an N-vinyl amide and a second monofunctional monomer being isobornyl acrylate, a difunctional acrylate monomer being propoxylated (or ethoxylated) neopentyl glycol di acrylate (SR 9003), at least one multifunctional monomer selected from the group consisting of a trifunctional acrylate monomer, a tetrafunctional acrylate monomer, a pentafunctional acrylate monomer, a trifunctional epoxide monomer, a tetrafunctional epoxide monomer, a pentafunctional epoxide monomer, a trifunctional oxetane monomer, a tetrafunctional oxetane monomer, a pentafunctional oxetane monomer, a trifunctional vinylether monomer, a tetrafunctional vinylether monomer and a pentafunctional vinylether monomer, the ink further includes at least one photoinitiator and a colorant.2012-10-18
20120264846Adhesive Compositions for Medical Use: Single Additive as Both the Thickening Agent and the Accelerator - The present invention relates to compositions of cyanoacrylate monomer, a method of improving the viscosity and the curing speed with a single additive and a process of providing sterilized cyanoacrylate adhesive compositions for application in the medical field.2012-10-18
20120264847NOVEL FOULING CONTROL COATING COMPOSITIONS - The present application discloses a fouling control coating composition comprising a polysiloxane-based binder system, 0.01-20% by dry weight of one or more hydrophilic-modified polysiloxanes, and one or more biocides. The hydrophilic-modified polysiloxane may be a poly(oxyalkylene)-modified polysiloxane, e.g. a polysiloxane having grafted thereto poly(oxyalkylene) chains and/or having incorporated in the backbone thereof poly(oxyalkylene) chains. The poly(oxyalkylene) may e.g. be selected from polyoxyethylene, polyoxypropylene and poly(oxyethylene-co-oxypropylene) (polyethylene glycols/polypropylene glycols). The application further discloses a marine structure comprising on at least a part of the outer surface thereof an outermost coating prepared from the coating composition. Moreover, the application discloses the use of the combination of non-reactive hydrophilic-modified polysiloxanes and biocides, wherein the weight ratio between the hydrophilic-modified polysiloxanes and the biocides is in the range 1:0.2 to 1:6, for improving the antifouling properties of a polysiloxane based coating composition.2012-10-18
20120264848POLYMER EMULSION FOR PAVEMENT SEALING - A pavement sealing composition and method of application of the sealant to pavement to form a thin coating which protects the pavement, particularly asphalt from the harmful effects of oxidation, water, ice and snow as well as fluids spilled onto the pavement surface from automobiles and aircraft. Preferably, the coating is formed of a polymer based emulsion.2012-10-18
20120264849METHOD FOR PREPARING A MASTERBATCH OF DIENE ELASTOMER AND SILICA - The invention relates to a method for preparing a silica/diene elastomer masterbatch, comprising the following successive steps: 2012-10-18
20120264850FRICTION ELEMENT FOR SYNCHRONIZING DEVICE - A friction element for a synchronizing device as well as an apparatus for producing a friction element for a synchronizing device are disclosed.2012-10-18
20120264851ARGILLACEOUS GYPSUM - Additives selected from primary, secondary, and tertiary alkyl amines and quaternary alkyl ammonium compounds are added to argillaceous gypsum compositions comprising comb polymers to improve the workability thereof. Argillaceous gypsum compositions, dispersing agents, a method for producing argillaceous gypsum compositions, and molded parts that can be produced from the gypsum compositions are also described.2012-10-18
20120264852POLYMERIC MATERIALS INCLUDING A GLYCOSAMINOGLYCAN NETWORKED WITH A POLYOLEFIN-CONTAINING POLYMER - The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.2012-10-18
20120264853METHOD OF MANUFACTURING A LAYER - A method of manufacturing a separate and continuous layer being essentially uncured. The method includes applying a powder mix including fibres and a thermosetting binder on a carrier, forming a powder mix layer, wherein the powder mix is connected together such that the powder mix layer is obtained and wherein the powder mix layer is essentially uncured, and releasing the powder mix layer from the carrier. Also, a layer and a method for manufacturing a building panel.2012-10-18
20120264854PROCESS FOR PRODUCING AQUEOUS DISPERSIONS OF ALIPHATIC POLYCARBONATES - Processes for producing aqueous dispersions of aliphatic polycarbonates are described herein. A solution of the aliphatic polycarbonate in at least one aprotic, organic solvent comprising at least 50% by volume ethyl acetate based on the total amount of the organic solvent is provided. The aliphatic polycarbonate solution is emulsified in an aqueous emulsification medium in the presence of at least one surface-active substance to produce an aqueous emulsion of the aliphatic polycarbonate solution. The apriotic, organic solvent is removed from the emulsion by vaporization.2012-10-18
20120264855CELLULOSE ESTER FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE - A cellulose ester film includes: a cellulose ester and at least one polyester, in which a number average molecular weight of the polyester is 2,500 or less and a ratio of components having a molecular weight of 500 or less in the polyester is less than 8%.2012-10-18
20120264856FLAME-RETARDANT THERMOPLASTIC MOLDING COMPOSITION - The invention relates to a thermoplastic molding composition free from halogens and from rare earth metals. The composition contains a polyalkylene terephthalate; a polyolefin selected from the group of polyethylene, polypropylene, polypropylene copolymers and mixtures of these; a flame retardant selected from the group of nitrogen-containing compounds, phosphorus-containing compounds and mixtures of thereof; and a reinforcing agent; and optionally another additive. The invention further relates to the use of the thermoplastic molding composition of the invention for producing fibers, foils or moldings, and also to fibers, foils or moldings which contain the thermoplastic molding composition of the invention. The invention further relates to the use of the thermoplastic molding composition as coating means.2012-10-18
20120264857PROCESS FOR PREPARING STABLE PHOTORESIST COMPOSITIONS - A composition of matter consisting of a stable solution containing a polymer derived from a solution of a polymer containing trace metals, the derived method comprising the steps of: 2012-10-18
20120264858COATING AGENT FOR THE PRODUCTION OF HIGH-IMPACT LAYERS - The invention relates to an aqueous coating composition comprising at least one liquid-crystalline aqueous preparation (WZ) in fractions of 1% to 99% by weight, based on the aqueous basecoat material, at least one film-forming polymer (FP), and a crosslinking agent (V).2012-10-18
20120264859COPOLYMER DISPERSION FOR WATER WHITENING RESISTANT COATINGS - The present invention provides an aqueous copolymer dispersion comprising a copolymer and a polyamine, the copolymer comprises, as copolymerized units, at least one nonionic monomer selected from (meth)acrylate C2012-10-18
20120264860Water-Soluble Product - Products which decompose when exposed to water are disclosed. The products comprise polyvinyl alcohol, talc, polyethylene glycol, and one or more of fiberglass and a titanium complex. The hardness or softness of the products may be varied by varying the relative amounts of talc, fiberglass, and titanium complex used therein. The products may be formed into items such as golf tees, stakes for ground-anchored structures, pellets for firearms, survey stakes and flags.2012-10-18
20120264861POWDER REDISPERSIBLE IN WATER, PROCESS FOR PRODUCTION THEREOF AND USE THEREOF - The present invention relates to a process for the production of powders redispersible in water comprising an organic component and a water-soluble organic polymeric protective colloid. The organic component is dispersed and stabilized with the protective colloid in water to form a stable dispersion which is dried to form the powder redispersible in water. The organic component comprises abietic acid, sylvic acid, neoabietic acid, levopinaric acid, pimaric acid, isopimaric acid and/or palustric acid and/or their derivatives. The water-soluble organic polymeric protective colloid comprises synthetic protective colloids and naturally and/or synthetically produced biopolymer which can be synthetically modified. The obtained powder reduces efflorescence in hydraulically set systems.2012-10-18
20120264862THERMAL TRANSFER IMAGE-RECEIVING SHEETS - The present invention relates to a thermal transfer image-receiving sheet including a dye receiving layer formed of a resin composition for thermal transfer image-receiving sheets, wherein said resin composition includes a resin composition (A) containing a graft polymer (A0) which contains a main chain segment (A1) formed of a polyester resin obtained by polycondensing an alcohol component containing an alkyleneoxide adduct of 2,2-bis-hydroxyphenyl)propane in an amount of 50 mol % or more with a carboxylic acid component, and a side chain segment (A2) formed of an addition polymer-based resin, and has a glass transition temperature of 50° C. or higher; and a resin composition (B) containing a resin (BO) and having a glass transition temperature lower by from 10 to 80° C. than the glass transition temperature of the resin composition (A), and to a process for producing the thermal transfer image-receiving sheet.2012-10-18
20120264863POLYMERIC DEFOAMER ADDITIVE - The present invention relates to a cost-effective and environmentally friendly polymeric defoamer formulation for use in various industrial applications that does not contain oil, EBS or free silicone.2012-10-18
20120264864MODIFIED POLYAMIDE COMPOSITION CONTAINING AT LEAST ONE PHENOLIC COMPOUND - The use of a phenolic compound for producing a modified polyamide having enhanced mechanical properties is described. A polyamide composition including at least such phenolic compound and optionally reinforcing or filler loads is also described. The composition is preferably a composition for molding, for example in the form of granules or powder, that can be used for the production of articles by injection-molding.2012-10-18
20120264865NARROW PARTICLE SIZE DISTRIBUTION CALCIUM CARBONATE AND METHODS OF MAKING SAME - Calcium carbonate particles having very narrow particle sizes with a controlled D2012-10-18
20120264866ACID MODIFIED NATURAL FILLER TO INITIALIZE THE BETA-NUCLEATION OF POLYPROPYLENE - The present invention relates to a composition for beta-nucleation of polypropylene, comprising: (a) a particulate mineral solid support, comprising a compound of a IUPAC Group 2 metal, and (b) on the surface of the particulate solid support (b1) a salt of a dicarboxylic acid, wherein the dicarboxylic acid has from 7 to 10 carbon atoms, and (b2) a dispersing and/or grinding agent.2012-10-18
20120264867PROCEDURE FOR MANUFACTURE OF AQUEOUS SUSPENSIONS OF CALCIUM CARBONATE AND SUSPENSIONS OBTAINED, AND THEIR USES - The object of the invention consist of a process for the manufacture of aqueous suspensions of calcium carbonate using an acrylic polymer with an average by weight molecular weight of between 8,000 g/mole and 15,000 g/mole and a molar content of less than 20% of polymeric chains of molecular weight less than 3,000 g/mole. It also concerns the aqueous suspensions obtained, possibly dried, and their uses in the paper, paint, plastics and mastics industry.2012-10-18
20120264868Reflectors for Light-Emitting Diode Assemblies Containing a White Pigment - Polymer compositions are described containing a white pigment for increasing the reflectance properties of the resulting material. In this regard, the material is well suited for being used as a reflector, such as a reflector for light-emitting diode assemblies. In accordance with the present disclosure, the white pigment comprises chalk resistance particles. The particles can also display a basic pH when placed in distilled water.2012-10-18
20120264869Thermoplastic Resin Composition and Molded Product Using the Same - Provided are a thermoplastic resin composition including a thermoplastic resin and a metal particle obtained by punching that has a ratio of thickness relative to long diameter of about 1:7 to about 1:1, and a molded product using the same.2012-10-18
20120264870COMPOSITIONS USEFUL FOR PREPARING COMPOSITES AND COMPOSITES PRODUCED THEREWITH - A composite prepared using a thermosettable epoxy resin composition having, as components: (1) an epoxy resin; (2) an epoxidized cycloaliphatic dicyclopentadiene phenolic resin; (3) an optional epoxidized bisphenol-A novolac resin; (4) an optional oligomeric butadiene; (5) an optional organic solvent; and (6) an alkylphenol novolac resin, the alkylphenol novolac resin serving as a curing agent. The composite so prepared may have good physical properties and superior a electrical properties as compared to conventional composites, such as laminates. The prepregs used to make the laminates may have a better surface appearance as well.2012-10-18
20120264871Silicone-Based Impact Modifier Including a Graft Copolymer Having a Core-Shell Structure and Thermoplastic Resin Composition Including the Same - A silicone-based impact modifier including a core-shell graft copolymer is disclosed. The silicone-based impact modifier includes a core made of a silicone-based rubber and alkyl acrylate and a shell made from an inorganic acrylate compound. Also disclosed is a thermoplastic resin composition including the silicone-based impact modifier.2012-10-18
20120264872LCST POLYMERS - The invention relates to LCST polymers and their preparation and use.2012-10-18
20120264873SUGAR MIXTURES AND METHODS FOR PRODUCTION AND USE THEREOF - A sugar mixture comprising: monosaccharides; oligosaccharides in a ratio ≧0.06 to total saccharides; disaccharides in a ratio to total saccharides ≧0.05; pentose in a ratio to total saccharides ≧0.05; at least one alpha-bonded di-glucose; and at least one beta-bonded di-glucose. Also disclosed are methods to make and/or use such mixtures.2012-10-18
20120264874DISPERSION AND AQUEOUS COATING COMPOSITION COMPRISING THE DISPERSION - The present invention relates to a dispersion comprising an acryl-modified cellulose ester derivative (D) dispersed in an aqueous medium, wherein a hydrophobic acrylic resin (B) and a hydrophilic acrylic resin (C) are grafted onto a cellulose ester derivative (A) in the acryl-modified cellulose ester derivative (D). The dispersion has excellent long-term storage stability, and aqueous coating compositions comprising the dispersion can form coating films with excellent coating workability, solvent resistance, chemical resistance, water resistance, and excellent curability.2012-10-18
20120264875METHOD FOR PREPARING A MASTERBATCH OF NATURAL RUBBER AND SILICA - The invention relates to a method for preparing a silica/natural rubber masterbatch, comprising the following successive steps: 2012-10-18
20120264876PROTECTIVE COATINGS FOR HIGH STRENGTH STEELS - A process for coating a metallic surface of an aircraft. The process includes applying to the metallic surface a composition that polymerizes to form a polyurea having a tensile strength of more than 3500 psi and at least 700% elongation. The polyurea can be formed from an A-side and a B-side, where the weight percents of components for the A-side are: from about 30 to about 65 percent of polyisocyanate; from about 15 to about 70 percent of a polytetramethylene ether glycol; diluent, from 0 to about 20 percent; where the weight percents of components for the B-side are: from 35 to about 40 percent of one or more aromatic diamines; from about 20 to about 70 percent of one or more amine terminated polyether polyols.2012-10-18
20120264877PROCESS FOR PRODUCING ULTRAFINE POWDERS BASED ON POLYAMIDES, ULTRAFINE POLYAMIDE POWDERS AND THEIR USE - Process for preparing ultrafine powders based on polyamides by contacting polyamides having a relative solution viscosity η2012-10-18
20120264878BINDER FOR SECONDARY BATTERY ELECTRODES - A binder for secondary battery electrodes contains a copolymer latex obtained by emulsion polymerization of a monomer composition containing 12.0 to 39.5 wt % of an aliphatic conjugated diene-based monomer, 1.5 to 8.5 wt % of an unsaturated carboxylic acid alkyl ester monomer, 0.1 to 10.0 wt % of an ethylene-based unsaturated carboxylic acid monomer, and 42.0 to 86.4 wt % of a monomer that is copolymerizable therewith, wherein 50 to 100 wt % of the copolymer latex is toluene-insoluble.2012-10-18
20120264879PRODUCING COATINGS BASED ON LCST POLYMERS - This invention relates to a process for producing coatings based on an LCST polymer and to formed articles obtainable by the process.2012-10-18
20120264880Block Copolymer with Simultaneous Electric and Ionic Conduction for Use in Lithium ION Batteries - Redox reactions that occur at the electrodes of batteries require transport of both ions and electrons to the active centers. Reported is the synthesis of a block copolymer that exhibits simultaneous electronic and ionic conduction, A combination of Grignard metathesis polymerization and click reaction was used successively to synthesize the block copolymer containing regioregular poly(3-hexylthiophene) (P3HT) and poly(ethylene oxide) (PEO) segments. The P3HT-PEO/LiTFSI mixture was then used to make a lithium battery cathode with LiFePO2012-10-18
20120264881HETEROTRIFUNCTIONAL MOLECULES AND METHODS FOR THE SYNTHESIS OF DENDRIMERIC MATERIALS - In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.2012-10-18
20120264882Thermoplastic Resin Composition and Molded Product Using Same - Provided are a thermoplastic resin composition that includes (A) about 60 to about 95 wt % of a base resin including (A-1) polyalkyl(meth)acrylate resin and (A-2) a vinyl-based copolymer; and (B) about 5 to about 40 wt % of a core-shell structured copolymer including a polymer of at least two compounds selected from an aromatic vinyl compound, a vinyl cyanide compound, and an acrylic-based compound, grafted on a rubbery polymer, and a molded product using the same.2012-10-18
20120264883SOFT POLYOLEFIN COMPOSITIONS WITH IMPROVED PROCESSABILITY - Soft polyolefin composition with improved processability comprising from 8 to 45% by weight of a polypropylene component (A), from 45 to 82% by weight of a polyolefin component (B), and from 5 to 25% by weight of a butene-1 (co)polymer (C) having a flexural modulus of 60 MPa or less.2012-10-18
20120264884Amphiphobic Surfaces from Block Copolymers - Provided are amphiphobic block copolymers, methods for preparing amphiphobic block copolymers, and applications thereof. Amphiphobic block copolymers can be used to prepare amphiphobic coatings on material surfaces, such as glass, printing paper or fabric. Amphiphobic block copolymers can also be used to coat particles, e.g., silica nanoparticles, which are then used to coat material surfaces. Such coated particles and uses thereof are also provided herein.2012-10-18
20120264885Hydrophobically and Cationically Modified Relative Permeability Modifiers and Associated Methods - Methods comprising providing a relative permeability modifier that comprises a hydrophilic polymer backbone with a hydrophobic modification and incorporating at least one cationic compound onto the hydrophilic polymer backbone. The hydrophilic polymer is one or more of: a polyacrylamide; a polyvinylamine; a poly(vinylamine/vinyl alcohol); an alkyl acrylate polymer; cellulose; chitosan; a polyamide; a polyetheramine; a polyhydroxyetheramine; a polylysine; a polysulfone; a gum; or a starch. The hydrophobic modification is achieved either by reacting the hydrophilic polymer with a hydrophobic compound or by a polymerization reaction product of a hydrophilic monomer and a hydrophobically modified hydrophilic monomer. The hydrophobic compound has an alkyl chain length from 4 to 22 carbons and is one or more of: an alkyl acrylate; an alkyl methacrylate; an alkyl acrylamide; an alkyl methacrylamide; or an alkyl dimethylammoniumethyl methacrylate halide.2012-10-18