| 42nd week of 2008 patent applcation highlights part 47 |
| Patent application number | Title | Published |
|---|
| 20080255138 | Novel Polymorphic Form Of Imatinib Mesylate And A Process For Its Preparation - This invention discloses a novel stable crystal form of imatinib mesylate, designated by us as α | 2008-10-16 |
| 20080255139 | Use Of 4- (4-Methylpiperazin-1-Ylmethyl)-N-[4-Methyl-3-(4-(Pyridin-3-Yl)Pyrimidin-2-Ylamino)Phenyl]-Benzamide to Inhibit the Tyrosine Kinase Receptor C-Fms - This invention relates to the use of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide (also known as imatinib, gleevec, glivec, cgp57148b or STI571), or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment of c-fms-associated diseases including; choriocarcinoma, malignant histiocytosis, embryonal carcinoma, endometrial carcinoma, brain microglial tumours, sarcoidosis, microglial cell involvement in normal and variant Creutzfeld-Jacob disease, and amyotrophic lateral sclerosis. | 2008-10-16 |
| 20080255140 | Squaric Acid Derivatives as Inhibitors of Histone Deacetylase - This invention comprises the novel compounds of formula (I) | 2008-10-16 |
| 20080255141 | 2-(3-AMINOARYL) AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS - Novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles of formula (I) that selectively modulate, regulate, and/or inhibit signal transductions mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferation metabolic, allergic and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors. | 2008-10-16 |
| 20080255142 | Substituted Piperidine Derivatives as Somatostatin Sst1 Receptor Antagonists - Compound of the formula (I) wherein R | 2008-10-16 |
| 20080255143 | Inhibitors of Akt Activity - Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis. | 2008-10-16 |
| 20080255144 | Acylated Piperidines as Glycine Transporter Inhibitors - The invention provides a compound of formula (I) or a salt or solvate thereof: | 2008-10-16 |
| 20080255145 | Thiadiazole compounds and methods of use - The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders. | 2008-10-16 |
| 20080255146 | NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES - The present invention relates to a compound represented by the formula (I): | 2008-10-16 |
| 20080255147 | Heterocycles useful as modulators of ion channels - The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 2008-10-16 |
| 20080255148 | THERAPEUTIC AGENT FOR SENILE DEMENTIA - A therapeutic/preventive agent for cognitive dysfunctions, which comprises as an active ingredient an imide derivative of the following formula [1]: | 2008-10-16 |
| 20080255149 | Carboxyamine Compounds and Methods of Use Thereof - The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases. | 2008-10-16 |
| 20080255150 | Novel Compounds - The invention relates to substituted aryl acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation. | 2008-10-16 |
| 20080255151 | N-DEACETYLTHIOCOLCHICINE DERIATIVES, THEIR USE AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM - Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I | 2008-10-16 |
| 20080255152 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS - A compound of the formula (I) wherein the variables X | 2008-10-16 |
| 20080255153 | New compounds - The present invention relates to compounds of formula (I): | 2008-10-16 |
| 20080255154 | Amido Compounds And Their Use As Pharmaceuticals - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 2008-10-16 |
| 20080255155 | KINASE INHIBITORS AND USES THEREOF - This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds, compositions and methods for the inhibition of kinase activity. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions. | 2008-10-16 |
| 20080255156 | ADENOSINE A2A RECEPTOR ANTAGONISTS - Compounds having the structural formula I | 2008-10-16 |
| 20080255157 | 6-Aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents - This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. | 2008-10-16 |
| 20080255158 | Fungicidal Mixtures - The invention relates to fungicidal mixtures containing in the form of active agents: a triazolopyrimidine derivative of formula (I) and thiophanate-methyl of formula (II) in synergistically active quantity and to a method for controlling harmful fungi by means of the mixture of the compounds I and II, thereby making it possible to produce said mixtures and the products containing them. | 2008-10-16 |
| 20080255159 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS - The present invention relates to substituted xanthines of general formula | 2008-10-16 |
| 20080255160 | MAPK/ERK KINASE INHIBITORS - Compounds of the following formula are provided for use with MEK: | 2008-10-16 |
| 20080255161 | 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS - The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like. | 2008-10-16 |
| 20080255162 | Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents - The present invention provides pyrimidines of Formula I: | 2008-10-16 |
| 20080255163 | Use of Modified Pyrimidine Compounds to Promote Stem Cell Migration and Proliferation - This invention provides cells and methods for stimulating proliferation and migration of endogenous and exogenous mammalian stem cells in vivo and in vitro. The invention provides reagents and methods for efficiently proliferating mammalian stem cells in an animal in need thereof and producing stem cells that can be re-introduced into an animal in need thereof to alleviate neurological and corporal disorders. | 2008-10-16 |
| 20080255164 | Novel 2-Aminopyrimidinone Derivatives And Their Use - This invention relates to novel compounds having the structural formula I below: (I) and to their pharmaceutically acceptable salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia. | 2008-10-16 |
| 20080255165 | Pharmaceutical Compositions of the Isolated D-Enantiomer of the Quinazolinone Derivative Halofuginone - The present invention relates to pharmaceutical compositions comprising as an active ingredient an isolated, chirally pure D-enantiomer of the quinazolinone derivative halofuginone having increased therapeutic activity and decreased side effects compared to the corresponding racemic mixtures, the composition being substantially free of the L-enantiomer and useful in the treatment of diseases and disorders associated with fibrotic conditions or cell proliferation. | 2008-10-16 |
| 20080255166 | Dithiocarbamate derivatives and their use as antibacterial agents - The invention relates to the use of dithiocarbamate derivatives for the therapeutic or prophylactic treatment of infectious diseases in mammals (humans and animals) caused by bacteria, especially diseases like tuberculosis (TB) and lepra caused by mycobacteria and infectious diseases caused by staphylococci. The invention further relates to novel dithiocarbamate derivatives of the formula (I), wherein X is a bivalent residue selected from the group consisting of formulae having excellent antibacterial activities, and to pharmaceutical preparations containing the same. | 2008-10-16 |
| 20080255167 | Novel 2-Aminopyrimidine or 2-Aminiopyridinone Derivatives and Their Use - This invention relates to novel compounds having the structural formula I below and to their pharmaceutically acceptable salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia. | 2008-10-16 |
| 20080255168 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS - Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient. Also provided are topical formulations comprising DPD, TP and/or UP inhibitors and methods of using same. | 2008-10-16 |
| 20080255169 | Sulphonamide Derivatives - The invention relates to sulphonamide derivatives of formula (I), | 2008-10-16 |
| 20080255170 | Process for the Synthesis of Rosuvastatin Calcium - Present invention represents process for the preparation of HMG-CoA reductase inhibitors, in particular rosuvastatin calcium introducing L-malic acid as the source of chirality for the side chain. | 2008-10-16 |
| 20080255171 | Combination of Nilotinib with Farnesyl Transferase Inhibitors - The invention provides a pharmaceutical combination comprising:
| 2008-10-16 |
| 20080255172 | PYRIMIDINE DERIVATIVES - A compound of the following formula: | 2008-10-16 |
| 20080255173 | Novel Specific Caspase-10 Inhibitors - The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy. | 2008-10-16 |
| 20080255174 | Hydroalcoholic Extract Of Erythrina Mulungu, Pharmaceutical Compositions And Processes For Producing These Substances - The use of molecules for cholinergic and/or serotonergic system models, revealing pharmaceutical compositions comprising 11-OH-erythravine, erythravine, erythrartine, pharmaceutically acceptable isotherals, salts, byproducts and/or solvates thereof, optionally containing other erythrina byproducts, for the treatment of anxiety disorders; processes for obtaining said pharmaceutical compositions are also revealed. | 2008-10-16 |
| 20080255175 | Anti-cancer agents, compositions and methods of treating cancers - Compounds and compositions useful in methods for treating cancer in mammals. The compounds of the invention are of the formula: | 2008-10-16 |
| 20080255176 | QUINOLINE DERIVATIVES - The present invention relates to novel benzo[g]quinoline derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them. | 2008-10-16 |
| 20080255177 | ANTI-TUMOR ACTIVITY OF CCI-779 IN PAPILLARY RENAL CELL CANCER - This invention provides the method or use of CCI-779 in the treatment of papillary renal cell carcinoma. | 2008-10-16 |
| 20080255178 | Azaadamantane Ester and Carbamate Derivatives and Methods of Use Thereof - The invention relates to compounds that are substituted azaadamantane ester and carbamate derivatives, compositions comprising such compounds, and methods of using such compounds and compositions. | 2008-10-16 |
| 20080255179 | Acetamide and Carboxamide Derivatives of Azaadamantane and Methods of Use Thereof - The invention relates to compounds that are acetamide and carboxamide derivatives of azaadamantane, compositions comprising such compounds, and methods of using such compounds and compositions. | 2008-10-16 |
| 20080255180 | 4-Substituted Azaadamantane Derivatives and Methods of Use Thereof - The invention relates to compounds that are 4-substituted azaadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions. | 2008-10-16 |
| 20080255181 | Methods for treating podocyte-related disorders - The present invention relates to methods for treating or preventing podocyte-related diseases and disorders using compounds that modulate the calcium sensing receptor or pharmaceutical compositions comprising thereof. | 2008-10-16 |
| 20080255182 | Certain chemical entities, compositions, and methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 2008-10-16 |
| 20080255183 | N-[HETEROARYLCARBONYL]-3-THIENYL-L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS - The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to a5b1 antagonists that also exhibit appropriate selectivity profile(s) against other integrins. | 2008-10-16 |
| 20080255184 | Thienopyridine B-Raf Kinase Inhibitors - The present invention provides thienopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents. | 2008-10-16 |
| 20080255185 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY - Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression. | 2008-10-16 |
| 20080255186 | Pyrazolo[3,4-B]Pyridine Compound, and Its Use as a Pde4 Inhibitor - The invention provides N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-3-methyl-5-isoxazolecarboxamide | 2008-10-16 |
| 20080255187 | 5-HT4 RECEPTOR AGONIST COMPOUNDS - The invention provides novel quinolinone-carboxamide 5-HT | 2008-10-16 |
| 20080255188 | Muscarinic Receptor Antagonists - This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. | 2008-10-16 |
| 20080255189 | HEPATITIS C VIRUS INHIBITORS - A compound of the following formula: | 2008-10-16 |
| 20080255190 | 8-Cyanoquinolonecarboxylic Acid Derivative - To provide a quinolone antibacterial drug and a therapeutic agent for infectious diseases, which exhibit potent antibacterial activity on Gram-positive and Gram-negative bacteria and which is highly safe. | 2008-10-16 |
| 20080255191 | BENZYLIMIDAZOLYL SUBSTITUTED 2-QUINOLINE AND QUINAZOLINE DERIVATIVES FOR USE AS FARNESYL TRANSFERASE INHIBITORS - This invention comprises the novel compounds of formula (I) | 2008-10-16 |
| 20080255192 | Methods and Compositions for Selectin Inhibition - The present teachings relate to novel compounds of formula I: | 2008-10-16 |
| 20080255193 | Pharmaceutical Composition - A novel pharmaceutical composition comprising the NK | 2008-10-16 |
| 20080255194 | 1,2-Benzisoxazol-3-yl Compounds - This invention relates to novel 1,2-benzisoxazol-3-yl compounds, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an antagonist of both dopamine and serotonin receptors. | 2008-10-16 |
| 20080255195 | Compounds Which Have Activity at M1 Receptor and Their Uses in Medicine - Compounds of formula (I) and salts are provided: | 2008-10-16 |
| 20080255196 | Pesticide Thiazolyloxy Substituted Phenylamidine Derivatives - The present invention relates to aryloxy substituted phenylamidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions (I). | 2008-10-16 |
| 20080255197 | CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS - The present invention relates to compounds that bind to chemokine receptors, and having the formula | 2008-10-16 |
| 20080255198 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR - The present invention relates to compounds of formula (I) | 2008-10-16 |
| 20080255199 | Compounds Useful for the Synthesis of S- and R-Omeprazole and a Process for Their Preparation - The present invention relates to an improved method for the synthesis of the (S)- or (R)-enantiomer of omeprazole, characterized in that 2-[[(4-X-3,5-dimethylpyridin-2-yl)methyl]thio]-5-methoxy-1H-benzimidazole or 2-[[(4-X-3,5-dimethyl-1-ox-idopyridin-2-yl) methyl]thio]-5-methoxy-1H-benzimidazole, wherein X is a leaving group, is oxidized into the corresponding sulphoxide which is obtained as a crystalline compound. Recrystallisation of the thus obtained sulphoxide results in a compound of enhanced chemical and optical purity, which is subsequently transformed into the (S)- or (R)-enantiomer of omeprazole. | 2008-10-16 |
| 20080255200 | SUBSTITUTED BENZIMIDAZOLES - Disclosed herein are substituted benzimidazole-based proton pump modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 2008-10-16 |
| 20080255201 | PPAR ACTIVE COMPOUNDS - Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ. | 2008-10-16 |
| 20080255202 | Phenylthioacetic Acid Derivatives and Use Thereof - The present application relates to novel phenylthioacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis. | 2008-10-16 |
| 20080255203 | HETEROCYCLIC COMPOUNDS AND THEIR METHODS OF USE - The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof. | 2008-10-16 |
| 20080255204 | Agrochemical Formulation for Improving the Action and Plant Compatibility of Crop Protection Agents - The present invention relates to novel agrochemical formulations for treating plants, which formulations comprise, as cosolvent, propylene carbonate, and, if appropriate, further additives, to a process for preparing these formulations and to their use for treating plants and/or their habitat and for increasing the efficacy and plant compatibility of crop protection agents. | 2008-10-16 |
| 20080255205 | Multi-cyclic compounds and methods of use - The present invention relates to compounds of Formulas I and II, | 2008-10-16 |
| 20080255206 | Rxr Agonists and Antagonists, Alone or in Combination with Ppar Ligands, in the Treatment of Metabolic and Cardiovascular Diseases - The present invention relates to the use of one or more retinoid agonists and/or antagonists comprising retinoids with selective Retinoid X Receptor (RXR) agonistic or antagonistic activity alone or in combination with one or more peroxisome proliferator activated receptor (PPAR) ligands for the manufacture of a medicament for the (preferably oral or topical) treatment (this term including prevention/prophylaxis and/or therapy) of one or more manifestations of metabolic syndrome (also known as syndrome X), also called diseases hereinafter, especially from one or more manifestations thereof selected from the group consisting of diabetes type II, obesity, dyslipidemia, hypertension and polyneuropathy, each of which can also be linked with a high risk of cardiovascular diseases. Corresponding methods, the compounds and combinations for use in the treatment of the mentioned diseases and comparable invention embodiments are also described. | 2008-10-16 |
| 20080255207 | 5-Thioxo-1,5-Dihydro-2H-Pyrrol-2-One Derivatives As Liver X Receptor Modulators - The present invention relates to certain novel compounds of the Formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α(NR1H3) and/or β(NR1H2) and in treating clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them. | 2008-10-16 |
| 20080255208 | Fungicide Pyridinyloxy Substituted Phenylamidine Derivatives - The present invention relates to 2,5-di-substituted-4-pyridinyloxy-substituted-phenyl-amidine derivatives, notably to 2,5-dialkyl-4-pyridinyloxy-substituted-phenyl-amidine derivatives, of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions (I). | 2008-10-16 |
| 20080255209 | Combination of a NSAID and a PDE-4 inhibitor - The invention relates to the combined use of a PDE4 inhibitor and a conventional NSAID in the treatment of an inflammatory disease and/or an inflammation-associated disorder while minimizing gastrointestinal side effects, such as gastric erosions and ulcer, which are frequently associated with the use of conventional NSAIDs. A preferred PDE 4 inhibitor for this combination is roflumilast or a derivative thereof. A preferred conventional NSAID for this combination is diclofenac or a derivative thereof. | 2008-10-16 |
| 20080255210 | OXADIAZOLINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX - The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. | 2008-10-16 |
| 20080255211 | Oxadiazole Compounds - A compound of formula (I): | 2008-10-16 |
| 20080255212 | OXADIAZOLONES AND DERIVATIVES THEREOF AS PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) DELTA AGONISTS - The invention relates to oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing peroxisome proliferator activator receptor (PPAR) delta agonist activity comprising compounds of formula I, | 2008-10-16 |
| 20080255213 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS - Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides having a structure | 2008-10-16 |
| 20080255214 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS - The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed. | 2008-10-16 |
| 20080255215 | Combinations of Alkylalkanolamines and Alkylbisalkanolamines for Antimicrobial Compositions - An antimicrobial composition includes an effective amount of a biocide, and a biocide enhancer consisting of one or more compounds according to formula (I) and one or more compounds according to formula (II): | 2008-10-16 |
| 20080255216 | Diaryltriazoles as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 - 2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11&bgr;-hydroxysteroid dehydrogenase Type 1 enzyme (11&bgr;-HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity, insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11&bgr;-HSD-1. | 2008-10-16 |
| 20080255217 | PREVENTIVE OR THERAPEUTIC AGENT FOR CARDIAC DYSFUNCTION OR MYOCARDIAL INJURY CAUSED BY ISCHEMIA OR ISCHEMIA REPERFUSION - Disclosed herein is at least a method of preventing or treating cardiac dysfunction or myocardial injury caused by ischemia or ischemia reperfusion | 2008-10-16 |
| 20080255218 | Melanin-Concentrating Hormone Receptor Antagonists and Methods of Use - This invention relates generally to N-benzylamino cyclic thioureas, pharmaceutical compositions containing them, and their use as antagonists of melanin-concentrating hormone receptor (MCH receptor). | 2008-10-16 |
| 20080255219 | RUMEN PROTECTED ESSENTIAL AMINO ACIDS - Use of essential amino acid imines and compositions containing them as a source of rumen protected essential amino acids for ruminant animals. Preferred are histidine and methionine. | 2008-10-16 |
| 20080255220 | Therapeutic Substituted Gamma Lactams - Disclosed herein is a compound comprising | 2008-10-16 |
| 20080255221 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS - The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed. | 2008-10-16 |
| 20080255222 | PHARMACEUTICALLY ACTIVE BENZSULFONAMIDE DERIVATIVES AS INHIBITORS OF PROTEIN JUNKINASES - The present invention relates to benzsulfonamide derivatives of formula I and methods of use thereof. The benzsulfonamide derivatives of the present invention are efficient modulators of the JNK pathway. In particular the benzsulfonamide derivatives of the present invention are selective inhibitors of JNK 2 and 3. | 2008-10-16 |
| 20080255223 | Treatment and Prevention of Benign Pigmented Moles (Naevi) Using Artemisinine and the Derivatives Thereof - A method of treating a benign pigmented mole or a dermatomycosis. The method comprises locally applying to a subject in need thereof artemisinine and/or one or more structurally related compounds. Also disclosed is a plaster which comprises a topical formulation comprising artemisinine and/or one or more structurally related compounds. | 2008-10-16 |
| 20080255224 | PHARMACOLOGICAL TREATMENT OF PSORIASIS - The present invention relates generally to the prevention and treatment of psoriasis and psoriatic-related skin conditions via administration of a cannabinoid agonist, especially nabinone, either alone or in combination with other agents that possess anti-psoriatic pharmacological activity. | 2008-10-16 |
| 20080255225 | Botanical Extract Composition - The invention relates to a kit comprising: a first composition comprising leaves of Melissa Officinalis, or parts thereof; a second composition comprising Eleutherococcus senticosus, or parts thereof; a third composition comprising Avena sativa, or parts thereof; a fourth composition comprising Ballota Nigra, or parts thereof; a third composition comprising the roots of Glycyrrhiza glabra/gan cao, or parts thereof; and a sixth composition comprising roots of Uncaria Tomentosa, or parts thereof. The invention further relates to a kit for use as a medicament, to a kit for use in the treatment of disorders in mammals, like humans, horses, cows, pigs and pets, to a kit for use in the treatment of lupus, multiple sclerosis, rheumatoid arthritis, rheumatism, osteoporosis, asthma in humans or tale and mane eczema in horses, and to the use of the kit for the treatment of lupus, multiple sclerosis, rheumatoid arthritis, rheumatism, osteoporosis, asthma in humans or tale and mane eczema in horses. | 2008-10-16 |
| 20080255226 | STABILIZED ANTHOCYANIN COMPOSITIONS - The invention describes stabile anthocyanin compositions, methods to prepare such compositions and also methods of use of such compositions to treat various afflictions. The present invention describes unique compositions of an anthocyanin and a stabilizing compound such that the combination of the two components provides that the anthocyanin does not readily undergo degradation, such as oxidation, pH instability, etc. | 2008-10-16 |
| 20080255227 | NOVEL COMPOSITION AND METHOD FOR STABILIZING THE SAME - Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride. | 2008-10-16 |
| 20080255228 | Ascorbic Acid Complexes for Skin Care Including Treatment of Dark Skin & Wrinkles - This invention relates to certain complexes of ascorbic acid and its derivatives with certain aryl alkyl ketones; said complexes having being formed via a kinetically-controlled process, and having general chemical formula (I) in FIG. | 2008-10-16 |
| 20080255229 | Parenteral solution containing amiodarone in NNDMA (N,N,-Dimethylacetamide) - Disclosed herein are parenteral solutions containing 3-diethylaminoethoxy benzoyl-benzofurans, such as amiodarone, in a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of cardiac arrhythmias both supraventricular, ventricular as well as, the condition of cardiac arrest. | 2008-10-16 |
| 20080255230 | THERAPEUTIC FLUOROETHYLCYANO GUANIDINES - Disclosed herein is compound having a formula | 2008-10-16 |
| 20080255231 | POLYMORPHS OF RIVASTIGMINE HYDROGENTARTRATE - A crystalline rivastigmine hydrogentartrate of Form II and an amorphous rivastigmine hydrogentartrate of Form III. | 2008-10-16 |
| 20080255232 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation - Compounds useful in the treatment of disorders characterized by deposits of amyloid aggregates are herein described together with pharmaceutical compounds containing the same. In particular the compounds of the present invention are those having the Formula (I) as reported below, where the radicals have the meaning indicated in the description. | 2008-10-16 |
| 20080255233 | Isomeric mixtures of dinitro-octylphenyl esters and synergistic fungicidal mixtures therefrom - The present invention relates to an isomeric composition comprising isomers of dinitro-octylphenyl esters, wherein the 2,6-dinitro-4-(1-propylpentyl)phenyl ester isomer is present in an amount of less than 0.1 weight percent, based on the total weight of the isomeric composition and to synergistic fungicidal mixtures therefrom. | 2008-10-16 |
| 20080255234 | RUMEN PROTECTED LYSINE - Use of lysine imines and compositions containing them as a source of rumen protected lysine for ruminant animals. | 2008-10-16 |
| 20080255235 | Infusion and Injection Solution of Levodopa - An infusion or injection solution of Levodopa containing at least 10 mg/mL of Levodopa, or at least 5 mg/mL of Levodopa together with at least 0.5 mg/mL of at least one inhibitor of a Levodopa-metabolising enzyme is disclosed. The solution further contains a buffer, a physiologically acceptable sugar, such as glucose, a physiologically acceptable acid, such as hydrochloric acid, and optionally a stabilizer, and has a pH of lower than or equal to 6. There are also described a disposable syringe containing an infusion or injection solution of Levodopa, optionally together with a Levodopa-metabolising enzyme, and an infusion pump cassette containing an infusion or injection solution of Levodopa optionally together with a Levodopa-metabolising enzyme. | 2008-10-16 |
| 20080255236 | Methods and Composition Comprising 2-[(3-Chlorophenyl)Amino] Phenylacetic Acid for Alzheimer's Disease - The present invention is directed to a method of preventing or arresting the progression of Alzheimer's disease by administering to a patient having Alzheimer's disease a composition comprising an amount of 2-[(3-chlorophenyl)amino]phenylacetic acid, or a pharmaceutically acceptable salt thereof, sufficient to elicit a prophylactic or therapeutic effect. In some embodiments, the composition is administered orally, transdermally, intravenously, intrathecally, or by suppository. In some embodiments, the composition comprises a pharmaceutically acceptable carrier. | 2008-10-16 |
| 20080255237 | Pesticidal Composition - A pesticidal preparation comprises a pesticidal composition consisting essentially of a mixture of garlic oil and allyl isothiocyanates (AITCs) in the weight ratio of from 95:5 to 60:40. It is especially effective as a pesticide, especially against nematodes commonly found in the soil. | 2008-10-16 |
