41st week of 2010 patent applcation highlights part 36 |
Patent application number | Title | Published |
20100261161 | Method for determining the specific growth rate of a distinct cell population within a non-homogeneous system - The present invention provides a method for measuring the specific rate of ribosome synthesis for a distinct cell population, such as a distinct microbial population. For an actively growing (or non-growing) culture, the specific rate of ribosome synthesis is identical to the specific growth rate of the culture. With the method of the invention, researchers will be able to measure the specific growth rate of distinct cell populations in mixed cultures, such as biological reactor systems or environmental samples. In addition, the method of the invention provides the ability to identify members of a distinct cell population that are rapidly growing. | 2010-10-14 |
20100261162 | Methods of assaying for telomerase activity and compositions related to same - The present invention relates generally to the field of diagnostic and prognostic assays such as diagnostic assays for conditions associated with telomerase activity. More particularly, the present invention provides an assay for measuring telomerase activity as an indicator of cancer, an inflammatory disorder and/or a condition involving embryogenesis and/or requiring stem cell proliferation and agents and kits useful for same. Automated and partially automated assays permitting high throughput screening also form part of the present invention. The subject invention further contemplates methods of treatment using agents identified by the subject assay or where treatment protocols are monitored by the assay. | 2010-10-14 |
20100261163 | Method for simultaneous detection of Mycobacterium tuberculosis complex and identification of mutations in mycobacterial DNA resulting in the resistance of microorganisms to rifampicin and isoniazid on biological microarrays, set of primers, biochip, and set of oligonucleotide probes used in the method - The present invention relates to molecular biology, microbiology, and medicine and provides the method for detection of | 2010-10-14 |
20100261164 | Diagnostic detection of nucleic acids - This invention provides sensitive nucleic acid hybridization assay methods for the detection of target animal nucleic acids in a biological sample, such as acellular fluids. The methods are particularly useful in early diagnosis of animal diseases, particularly chronic illnesses. | 2010-10-14 |
20100261165 | Methods, Compositions and Kits for Use in Prognosis, Characterization and Treatment of Cancer - The present invention provides methods, compositions and kits for the prognosis, characterization and treatment of cancers. The methods, compositions and kits of the invention comprise a set of markers whose expression is correlated with estrogen receptor beta function. Therefore, the methods, compositions and kits of the invention find particular use in endocrine-related cancers such as breast cancers. | 2010-10-14 |
20100261166 | METHOD FOR SPECIFICALLY AND SENSITIVELY AMPLIFYING A TARGET SEQUENCE - The present invention aims to develop a method for amplifying only a target gene while reducing the noise from a non-target gene having a similar sequence, as well as to develop a new method of quantitation based on acquisition of the signal from the amplified sequence with high precision (in high sensitivity and specificity). | 2010-10-14 |
20100261167 | In vivo screen using chemical inducers of dimerization - A method for identifying a molecule that binds a known target in a cell from a pool of candidate molecules, comprising: (a) covalently bonding each molecule in the pool of candidate molecules to a methotrexate moiety to form a screening molecule; (b) introducing the screening molecule into a cell which expresses a first fusion-protein comprising a binding domain capable of binding methotrexate, a second fusion protein comprising the known target, and a reporter gene wherein expression of the reporter gene is conditioned on the proximity of the first fusion protein to the second fusion protein; (c) permitting the screening molecule to bind to the first fusion protein and to the second fusion protein so as to activate the expression of the reporter gene; (d) selecting which cell expresses the reporter gene; and (e) identifying the small molecule that binds the known target. | 2010-10-14 |
20100261168 | Screening for Environmental DNAs Encoding Enzymes for Synthesizing Terpenoid-Based Therapeutic Compounds Using Genetically Modified E. Coli Strains - A screening method for identifying microbial genes involved in biosynthesis of therapeutic terpenoid-based compounds using genetically modified | 2010-10-14 |
20100261169 | NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND METHODS OF USE THEREOF FOR DIAGNOSIS - The present invention relates to diagnostic markers comprising novel splice variants of known proteins and polynucleotides encoding same, useful in the qualitative and/or quantitative detection of various diseases and/or pathological conditions in a subject, and to the use of known proteins and polynucleotides encoding same for diagnosis. Particularly, the invention relates to the diagnosis of a disease in a sample of body fluid or secretion obtained from the subject, and to the diagnosis of cancer. | 2010-10-14 |
20100261170 | SCREENING METHODS AND SEQUENCES RELATING THERETO - Disclosed are screening methods and sequences related thereto. Disclosed are methods for detecting mutations in the MYH gene of an individual. Also disclosed are methods of genotyping and methods of predicting for an individual the likelihood of developing certain cancers, such as colorectal cancer. | 2010-10-14 |
20100261171 | NUCLEIC ACID SEQUENCES FOR BIOSYNTHESIS OF NON-MCCJ25-RELATED LARIAT PEPTIDES - A nucleic acid sequence is provided, encoding at least one of a precursor of a lariat peptide, a processing factor of a lariat peptide, and an export factor of a lariat peptide, wherein the lariat peptide is a non-MccJ25 lariat peptide according to general structural formula (I) Also provided are biosynthesis systems useful for the synthesis of peptides according to formula (I), and methods of detecting and identifying nucleic acid sequences encoding the disclosed proteins. | 2010-10-14 |
20100261172 | INTERFERON ALPHA-INDUCED PHARMACODYNAMIC MARKERS - The present invention encompasses type-I IFN and IFNα-induced PD marker expression profiles, kits, and methods for identifying such IFNα-induced PD marker expression profiles. The type-I IFN and IFNα-induced PD marker expression profiles may also be used in, for example, methods of treating patients having a type-I IFN or IFNα-mediated disorder, methods of monitoring disease progression of patients receiving treatment with a therapeutic agent that binds to and modulates IFNα activity, identifying patients as candidates to receive a therapeutic that binds to and neutralizes IFNα activity, and in diagnosing or providing a prognosis to patients having IFNα-induced disorders. | 2010-10-14 |
20100261173 | Identification Of Fat And Lean Phenotypes In Chickens Using Molecular Markers - The present invention provides methods of screening chickens to determine those more likely to have a lean or fat phenotype. The invention also provides methods of screening chickens to identify a polymorphism associated with a fat or lean phenotype. | 2010-10-14 |
20100261174 | Determination of 5-ASA efficacy in CRC prevention and/or treatment by gene expression analysis - A method is disclosed for the determination of 5-ASA efficacy in preventing and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of the β-catenin pathway in presence of 5-ASA. More in details, the method comprises measuring the expression of at least one gene involved in the regulation of the β-catenin signalling pathway, such as μ-protocadherin, E-cadherin, β-catenin, Axin1, ICAT, p21 | 2010-10-14 |
20100261175 | USE OF SHORT OLIGONUCLEOTIDES FOR REAGENT REDUNDANCY EXPERIMENTS IN RNA FUNCTIONAL ANALYSIS - The present invention relates to functional analysis of miRNAs or other short non-coding RNAs involving the use of two or more sequence distinct miRNAs antagonising oligomeric compounds, which enables the reagent redundancy experiments to reduce the risk of reporting false positive effects of miRNA/ncRNA antagonists. | 2010-10-14 |
20100261176 | Methods of Tissue-Based Diagnosis - The current invention provides methods, as well as compositions useful in such methods, involving application of energy to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). Determination of tissue composition can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications. | 2010-10-14 |
20100261177 | INCREASING SPECIFICITY IN A scFV SCREEN USING DUAL BAIT REPORTERS - To increase the efficiency of the selection of antibodies of desired specificity, we create multi-bait strain(s) in which one bait is the target and one or more bait(s) are non-target. The non-target bait(s) may use one or more DNA-binding domain(s) that differ(s) from that of the target bait and thereby activate one or more different reporters from that activated by the target bait. Library hits that activate both sets of reporters are presumed to be inadequately specific and can be eliminated from further consideration. Alternatively, a non-target bait may be replaced with a second target bait, and hits selected that activate both sets of reporters. Other combinations of elements can be used. | 2010-10-14 |
20100261178 | High Throughput Assays for Inhibitors and Activators of PAQR Receptors - The subject invention provides methods of screening compounds or ligands that interact with human and/or non-human PAQR receptors or fungal osmotin receptors. These methods utilize a colorimetric assay to ascertain whether a compound binds to and activates a PAQR receptor or the osmotin receptor. | 2010-10-14 |
20100261179 | SAMPLE PREPARATION DEVICES AND ANALYZERS - The application provides sample preparation devices and analyses. The devices and analyzes allow for the rapid preparation and analysis of samples using a variety of techniques, including PCR, by even unskilled users. | 2010-10-14 |
20100261180 | RECOMBINANT PERFORIN, EXPRESSION AND USES THEREOF - The present invention relates to retroviral vectors capable of driving the expression of perforin in a cell and a method of expressing recombinant perforin in a cell. The present invention also relates to recombinant perforin polypeptides and nucleic acid molecules derived therefrom and uses thereof. Also encompassed are screening assays employing such recombinant perforin molecules, compounds identified by the screening assays and uses thereof. | 2010-10-14 |
20100261181 | LABELING AND DETECTION OF NUCLEIC ACIDS - Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling nucleic acids with an azide group. | 2010-10-14 |
20100261182 | PPM1E PROTEINS AND NUCLEIC ACIDS AS TARGETS FOR NEURODEGENERATIVE DISEASES | 2010-10-14 |
20100261183 | METHOD OF DETERMINING RISK FOR CANCER - A method of determining risk of cancer in a mammal is provided. The method includes analyzing the genomic DNA of the mammal and determining genomic CNV frequency or genomic structural variation. An increase in either CNV frequency or genomic structural variation in comparison to a baseline mean value is indicative of cancer. | 2010-10-14 |
20100261184 | Micro-Chamber Plate, Manufacturing Method Thereof - The present invention relates to a micro-chamber plate and a manufacturing method of the same, more precisely a micro-chamber plate facilitating real-time measurement and analysis of fluorescence obtained from the reaction of multiple reaction solutions containing primers or probes selectively binding to each corresponding gene without cross-contamination in order to analyze biological samples containing numbers of genes and a manufacturing method of the same. | 2010-10-14 |
20100261185 | LABELED ENZYME COMPOSITIONS, METHODS AND SYSTEMS - Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are labeled polymerase conjugates including a polymerase linked to one or more labels, wherein the conjugate has polymerase activity. Such conjugates can exhibit enhanced biological activity and/or superior detectability as compared to conventional labeled polymerases. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing. | 2010-10-14 |
20100261186 | POLYMORPHISM IDENTIFICATION METHOD - The present invention is to provide a method for identifying a polymorphism with high sensitivity and high accuracy. The method of the present invention includes: performing a nucleic acid chain extension reaction and identifying the polymorphism of the nucleic acid contained in a test nucleic acid sample. The extension reaction is conducted with use of: a nucleic acid in a test nucleic acid sample as a template, a type I detection primer which hybridizes with a region including the polymorphic site of a nucleic acid whose polymorphic site nucleotide sequence consists of a first nucleotide sequence, and a polymerase having no strand displacement activity. The reaction is conducted with the presence of an inhibitory oligonucleotide which contains a nucleotide sequence complementary to the sequence of a region including the polymorphic site of a nucleic acid whose polymorphic site nucleotide sequence consisting of a second nucleotide sequence. | 2010-10-14 |
20100261187 | GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 2010-10-14 |
20100261188 | NON-INVASIVE PRENATAL GENETIC SCREEN - The present invention provides methods and kits useful for genetic testing or screening of fetuses using nucleic acid samples isolated from cervical mucus samples of fetus hosts. | 2010-10-14 |
20100261189 | System and method for detection of HLA Variants - A method for detecting one or more HLA sequence types is described that comprises the steps of: amplifying a plurality of first amplicons from a double stranded nucleic acid sample, wherein the first amplicons are amplified with a plurality of pairs of nucleic acid primers that define exons 2 and 3 of both strands of HLA loci from the group consisting of HLA-A, HLA-B, and HLA-C; amplifying the first amplicons to produce a plurality of populations of second amplicons, wherein each population of second amplicons is clonally amplified from one of the first amplicons; sequencing the plurality of populations of second amplicons to generate a nucleic acid sequence composition for each of the plurality of second amplicons; and detecting variation in the sequence composition from one or more of the second amplicons for one or more of the HLA loci. | 2010-10-14 |
20100261190 | Mammalian Genes; Related Reagents and Methods - Purified genes encoding proteins from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided. | 2010-10-14 |
20100261191 | STABLE CELL LINES EXPRESSING HERG - A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided. | 2010-10-14 |
20100261192 | CLONING OF CYTOCHROME P450 GENES FROM NICOTIANA - The present invention relates to p450 enzymes and nucleic acid sequences encoding p450 enzymes in | 2010-10-14 |
20100261193 | Valve Structure for Consistent Valve Operation of a Miniaturized Fluid Delivery and Analysis System - A valve structure of a fluid delivery and analysis system having an upper substrate, a lower substrate and an intermediate layer with at least one opening and at least one open cavity having a first touch point between the upper substrate and the intermediate layer and a second touch point between the lower substrate and the intermediate layer where the first touch point and the second touch point are offset to create a torque so that when intermediate layer is compressed between the upper substrate and the lower substrate that the torque deforms the intermediate rubber layer in the direction of the opening for better sealing. | 2010-10-14 |
20100261194 | NEUTROKINE-ALPHA ANTIBODIES AND METHODS OF USE THEREOF - The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody. | 2010-10-14 |
20100261195 | RAPID ANTEMORTEM DETECTION OF INFECTIOUS AGENTS - Methods for detection of the presence or absence of PrP | 2010-10-14 |
20100261196 | METHODS OF IDENTIFYING SMALL MOLECULES FOR RENEWALS, SURVIVAL AND MIGRATION OF CARDIAC PROGENITORS - The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor. | 2010-10-14 |
20100261197 | Method, System, and Compositions for Cell Counting and Analysis - The present invention provides a low cost imaged-based system for detecting, measuring and/or counting labeled features of biological samples, particularly blood specimens. In one aspect, the invention includes a system for imaging multiple features of a specimen that includes one or more light sources capable of successively generating illumination beams each having a distinct wavelength band and a plurality of differentially excitable labels capable of labeling a specimen comprising multiple features, such that each different feature is labeled with a different differentially excitable label. System of the invention may further include a controller operationally associated with the one or more light sources for successively directing illumination beams onto the specimen so that each of the different differentially excitable labels is successively caused to emit an optical signal within the same wavelength band, an optical system capable of collecting such emitted optical signals and forming successive images corresponding to the labeled features of the specimen on a light-responsive surface to form successive sets of image data thereof, and a disposable cuvette for collection and optical analysis of non-red blood cells. | 2010-10-14 |
20100261198 | METHODS OF DETECTION OF FACTOR XIA AND TISSUE FACTOR - The invention provides compositions and methods for the detection of Factor XIa or Tissue Factor (TF) activity in a sample using an antibody based clotting time prolongation assay. The invention provides methods for detection of FXIa or TF activity in a sample using a fluorogenic substrate. Further provided herein is a correlation between elevated levels of FXIa and/or TF with inflammation, acute coronary syndrome (ACS), myocardial infarction, coronary artery disease (CAD), heart failure, aortic stenosis, stroke, or transient ischemic attack. The frequency of FXIa and TF activity was substantially lower in individuals with stable coronary artery disease and no history of myocardial infarction. No FXIa or TF activity was observed in healthy individuals. | 2010-10-14 |
20100261199 | Assay for the detection of phosphorylated PTH - Antibodies for a variant of intact parathyroid hormone (PTH) or its fragments which have at position 17 the amino acid serine which is phosphorylated [p(17) PTH] and methods of producing the same. The invention further includes various immunoassay methods which use the described antibody alone or in combination with other antibodies to determine the circulating levels of p(17) intact PTH (1-84) or fragments thereof in biological fluids. Such antibodies and immunoassays can be used in conjunction with other antibodies to detect all biologically active forms of hPTH present in biological fluids. | 2010-10-14 |
20100261200 | Glycoprotein VI and Uses Thereof - The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 2010-10-14 |
20100261201 | ASSAY FOR MONITORING ACTIVITY OF FRIZZLED RECEPTORS - The present invention relates to cell free assays for measuring receptor activity, especially for measuring a constitutive or a non-constitutive activity of frizzled receptors and uses thereof. The present invention further concerns a method for measuring a constitutive or non-constitutive activity of a frizzled receptor and a method for obtaining an active frizzled receptor ligand. | 2010-10-14 |
20100261202 | METHOD FOR EFFICIENT PRODUCTION OF MONOCYTE-DERIVED MULTIPOTENT CELL (MOMC) - It is to provide a practical method for producing efficiently a large amount of MOMC, which is a multipotent cell which is very suitable for cell transplantation for organ regeneration. It was found that by culturing peripheral blood monocytes in vitro on fibronectin in the presence of SDF-1, MOMC can be produced more efficiently, and the present invention has been completed. Specifically, it is a method for producing MOMC by culturing in vitro peripheral blood monocytes expressing CD14 on fibronectin, wherein the in vitro culture is performed in the presence of SDF-1. | 2010-10-14 |
20100261203 | Methods and kits for screening transplant recipients and candidates - Methods and kits are provided for determining of immunoglobulin isotypes and subclasses in a subject. In general the subject is a human who is a transplant candidate recipient or recipient, has allergies, or has an autoimmune disease. The method involves analyzing a sample of a body fluid of a transplant candidate or recipient, allergy patient or autoimmune disease sufferer and correlating the relative amounts of each immunoglobulin isotype and subtype, such that the distribution of isotypes and subtypes is an indication of success of the transplant in the candidate and recipient or the prognosis of the autoimmune disease. | 2010-10-14 |
20100261204 | Composite Profiles of Cell Antigens and Target Signal Transduction Proteins for Analysis and Clinical Management of Hematologic Cancers - The present invention is directed to methods for establishing a composite marker profile for a sample derived from an individual suspected having a neoplastic condition. A composite marker profile of the invention allows for identification of prognostically and therapeutically relevant subgroups of neoplastic conditions and prediction of the clinical course of an individual. The methods of the invention provide tools useful in choosing a therapy for an individual afflicted with a neoplastic condition, including methods for assigning a risk group, methods of predicting an increased risk of relapse, methods of predicting an increased risk of developing secondary complications, methods of choosing a therapy for an individual, methods of determining the efficacy of a therapy in an individual, and methods of determining the prognosis for an individual. In particular, the method of the present invention discloses a method for establishing a composite marker profile that can serve as a prognostic indicator to predict whether the course of a neoplastic condition in a individual will be aggressive or indolent, thereby aiding the clinician in managing the patient and evaluating the modality of treatment to be used. In particular embodiments disclosed herein, the methods of the invention are directed to establishing a composite marker profile for a leukemia selected from the group consisting of Chronic Lymphocytic Leukemia (CLL), Acute Myelogenous Leukemia (AML), Chronic Myelogenous Leukemia (CML), and Acute Lymphocytic Leukemia (ALL). | 2010-10-14 |
20100261205 | MICROCHIPS, KITS, AND METHODS FOR IMMUNOASSAYS - An objective of the present invention is to provide immunoassay microchips in which microstructures of beads having a sufficient reaction area were constructed within microchannels while suppressing flow path resistance, and to provide simple and highly-sensitive immunoassay methods for microsamples. The objective was achieved by immunoassay microchips comprising microchannels with microstructures arranged in at least a portion of the microchannels, the microstructures retaining microbeads uniformly dispersed in photo-cured hydrophilic resins, and the microbeads having a primary antibody immobilized on their surfaces, and by immunoassay methods using the microchips. | 2010-10-14 |
20100261206 | Peptide fragments reacting specifically with antibodies against highly pathogenic newcastle disease virus and uses thereof - We disclose synthetic peptide fragments comprising amino acid sequences of specific antigen sites of pathogenic Newcastle disease virus in birds, and more particularly synthetic peptide fragments that comprise polybasic amino acid sequences at the cleavage site of the F protein of pathogenic Newcastle disease virus and that induce humoral immune responses in hosts while reacting only with antibodies to pathogenic Newcastle disease virus and are useful to differentiate infected individuals from vaccinated individuals. | 2010-10-14 |
20100261207 | NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT - The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention. | 2010-10-14 |
20100261208 | ELISPOT METHOD HAVING TWO FILTER SYSTEMS - An ELISPOT method for in vitro diagnosis and/or in vitro therapy monitoring of infections and/or infectious diseases comprising incubating eukaryotic cells with an antigen, measuring the number of immunocompetent cells which secrete at least two different cytokines as a reaction to the antigen, and in measuring the immunocompetent cells, visualizing the cells with the aid of at least two different dyes and at least two different filter sets, the filter sets comprising narrowband filters. | 2010-10-14 |
20100261209 | BIOMARKERS FOR LIVER DISEASES AND METHOD FOR USING THE SAME - Biomarkers for liver diseases and method for using the same are provided. For detecting liver cirrhosis and liver cancer, the biomarkers are selected from any one of the amino acid sequences with SEQ ID NO:1 to SEQ ID NO:24 or derivatives or fragments or variants or the combination thereof or the antibodies against the amino acid sequences. Then the biomarkers are further developed into detection kits, such that by detecting the existence of autoantibodies or autoantigens in screened specimens, liver diseases are detected with higher accuracy and sensitivity. | 2010-10-14 |
20100261210 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PROSTATE CANCER - A method of treating prostate cancer is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of MCP-1 or of an effector thereof, thereby treating the prostate cancer in the subject. | 2010-10-14 |
20100261211 | METHOD AND APPARATUS FOR MONITORING SPATIAL FIBRIN CLOT FORMATION - The present invention relates to a method, a special designed cuvette ( | 2010-10-14 |
20100261212 | KINETICS OF MOLECULAR RECOGNITION MEDIATED NANOPARTICLE SELF-ASSEMBLY - A method of multiple protein biomarker detection, comprising providing at quantum dot-antibody conjugates that have an affinity for at least two different protein biomarkers; contacting the conjugates with a sample from a subject; allowing the proteins to bridge the antibodies, forming protein biomarker/quantum dot-antibody conjugate agglomerates; detecting the presence of the biomarkers by excitation of the agglomerates. | 2010-10-14 |
20100261213 | METHOD FOR LARGE SCALE PREPARATION OF THE ACTIVE DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE WITHOUT FUSION PROTEIN - The present invention relates to protein tyrosine phosphatase (PTP) and a method for preparing the same, precisely, a method for expressing PTP active domain with high activity and stability without help of a fusion protein, by using computer based protein structure prediction technique. PTP prepared by the method of the present invention can be effectively used as a protein for high efficiency drug screening for the development of a novel drug, as an antigen protein for the construction of a selective antibody and as a protein for the studies of PTP structure and functions. | 2010-10-14 |
20100261214 | Method for Determining ACE2 Activity - The present invention relates to a method of determining ACE2 activity, comprising the following steps: providing ACE2-binding units immobilized on a solid carrier and specific for a part of ACE2 which is not involved in the catalytic activity of ACE2; contacting the immobilized ACE2-binding units with a sample which potentially includes the ACE2, wherein the ACE2 is bound by the ACE2-binding unit; removing the non-binding portions of the sample from the ACE2 bound to the ACE2-binding units; adding a substrate of the ACE2 which is reacted by the ACE2 activity, with the reaction providing a signal; and measuring the change in the signal during a specific period of time, wherein the change can be correlated with the ACE2 activity. | 2010-10-14 |
20100261215 | NON-INVASIVE METHOD FOR COLLECTING BIOLOGICAL DATA FOR ESTABLISHING A DIAGNOSIS OF A CUTANEOUS PATHOLOGY - A non-invasive method for collecting biological data useful for establishing a diagnosis or a prognosis of a particular cutaneous pathology in a patient, includes:
| 2010-10-14 |
20100261216 | STABILITY TESTING OF ANTIBODIES - Antibodies are biological macromolecules which may be subject to modification and degradation processes. A new LC/MS-based method for separating and characterizing antibody-specific degradation products is described in the present application which comprises an enzymatic digestion step to cleave the heavy chain using the enzyme IdeS. | 2010-10-14 |
20100261217 | Secreted and transmembrane polypeptides and nucleic acids encoding the same - The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 2010-10-14 |
20100261218 | METHODS FOR PRODUCING SECONDARY METABOLITES - The invention relates to methods for producing secondary metabolites using transformed | 2010-10-14 |
20100261219 | TEST METHOD OF BIOAVAILABILITY AND BIOEQUIVALENCE FOR XENOBIOTICS USING GENETIC PROFILING - Disclosed is a test method of bioavailability or bioequivalence for xenobiotics, comprising selection of test subjects (human or animal) based on the genetic information for metabolic enzymes or transporters that influence pharmacodynamics or pharmacokinetics for xenobiotics, and testing bioavailability or bioequivalence of the same. | 2010-10-14 |
20100261220 | Biological system and assay for identifying modulators of tubulin ligases - is used as a host cell in a biological assay for identification of modulators of tubulin ligases. | 2010-10-14 |
20100261221 | METHOD TO PREDICT OR DIAGNOSE A GASTROINTESTINAL DISORDER OR DISEASE - The disclosure provides methods and compositions useful for identifying a subject's predisposition to a gastrointestinal disease or disorder. | 2010-10-14 |
20100261222 | CELL CULTURE MEASURING SYSTEM AND METHOD FOR COMPARATIVE INVESTIGATIONS ON CELL CULTURES - The invention relates to a cell culture measuring system and to a method for comparative investigations on cell cultures. It is the object of the invention to propose possibilities with which comparative investigations can be carried out on cell cultures under the same conditions on cells which are influenced by a test liquid and on cells which are not influenced by test liquid. In a cell culture measuring system in accordance with the invention, cell cultures are cultivated on a cell culture carrier within a flow passage. An inflow and an outflow for a liquid culture medium and at least two sensors are present. In addition, at least one further inflow for a test liquid is arranged in the flow direction of the culture medium between the inflow for the culture medium and the outflow of the flow passage so that the test liquid flowing through the flow passage by displacement of the culture medium only flows around and/or over some of the cells present on the cell culture carrier. In addition, at least one sensor is arranged in the region of the cells not influenced by test liquid and at least one further sensor is arranged in the region of cells influenced by test liquid. | 2010-10-14 |
20100261223 | DEVICE FOR DETECTING COMPONENTS IN A FLUID - A device and a method for detecting components in blood, in particular for determining the concentration of components in blood or water is provided. Moreover, a use of a device and/or a method for determining components in blood is provided and a kit including the device and a fluorescence standard. | 2010-10-14 |
20100261224 | DISCOVERY AND VALIDATION OF CANCER BIOMARKERS USING A PROTEIN ANALYSIS METHODOLOGY TO ANALYZE SPECIMENS - Methods are provided for the analysis, including the serial analysis, of very small samples of tissue. The methods utilize a nanofluidic proteomic immunoassay (NIA) to quantify total and low-abundance protein isoforms in a small amount of lysate. NIA detection accurately measure oncoprotein expression and activation in limited clinical specimens, including isoforms that differ in post-translational modifications, such as phosphorylation, and the like. The NIA detection method combines isoelectric protein focusing and antibody detection in a nanofluidic system. | 2010-10-14 |
20100261225 | APPARATUS AND METHOD FOR ANALYZING BACTERIA - An apparatus for analyzing bacteria is described that includes an analytic sample preparation section for preparing an analytic sample by treating a specimen so as to generate a morphological difference between Gram-negative bacteria and Gram-positive bacteria, a detector for detecting optical information from each particle contained in the analytic sample and an analyzing section for detecting Gram-positive bacteria contained on the basis of the detected optical information. A method for analyzing bacteria is also described. | 2010-10-14 |
20100261226 | UNIVERSAL BIOREACTORS AND METHODS OF USE - Bioreactors suitable for housing a predetermined volume of culture medium comprising a plurality of containers of approximately equal internal volume in which the culture medium resides, wherein the predetermined volume of culture medium is retained in approximately equal amounts within each of the plurality of containers during operation of the bioreactor, and wherein the internal volume of each container is selected so that the amount of culture medium in each container exceeds 50 vol. % of the container internal volume during operation of the bioreactor, and related methods of use. | 2010-10-14 |
20100261227 | Production of Proteins Using Transposon-Based Vectors - Novel compositions for the in vitro or in vivo production of specific proteins are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes for the protein of interest, and the transposon-based vectors comprising these components. Also provided are methods of making these compositions and methods of using these compositions for the production of desired proteins in vivo or in transfected cells in vitro. | 2010-10-14 |
20100261228 | MULTIPLEXED SITES FOR POLYMER SYNTHESIS - Disclosed herein are methods, devices, and other components for synthesizing polymers. In some embodiments, numerous sites can be multiplexed together to allow for effective nucleic acid synthesis. | 2010-10-14 |
20100261229 | SYSTEM AND METHOD FOR PREPARING AND USING BULK EMULSION - An emulsion generation apparatus and method for forming an emulsion are provided wherein a customized impeller design is adapted to form an emulsion with a desired droplet size that defines a desired volume. The emulsion generation apparatus provides improved uniformity in emulsion preparation and may be used to create large or small volume emulsions rapidly and reproducibly. A system and method are also provided for large volume sample amplification adaptable for use with conventional PCR-based reactions as well as emulsion-based PCR reactions and other reactions. For applications involving emulsion-based PCR amplification, the system and method provide improved uniformity in emulsion amplification and can be used to amplify large or small volume emulsions rapidly and reproducibly. | 2010-10-14 |
20100261230 | SYSTEM COMPRISING DUAL-SIDED THERMAL CYCLER AND EMULSION PCR IN POUCH - A system and method are provided for large volume sample amplification adaptable for use with conventional PCR-based reactions as well as emulsion-based PCR reactions. A sample is retained in a pouch or flexible bag which permits bulk PCR amplification with efficient heat-transfer properties. For applications involving emulsion-based PCR amplification, the system and method provide improved uniformity in emulsion amplification and can be used to amplify large or small volume emulsions rapidly and reproducibly. | 2010-10-14 |
20100261231 | Dinucleotide MRNA CAP Analogs - Novel cap analogs which are easily synthesized, resulting in high levels of capping efficiency and transcription and improved translation efficiencies are provided. Such caps are methylated at the N7 position of one or both guanosines of the dinucleotide cap as well as at the 3′ position on the ribose ring. Substituent groups on the ribose ring also result in the cap being incorporated in the forward orientation. Also provided are methods useful for preparing capped analogs and using mRNA species containing such analogs are also contemplated herein, as well as kits containing the novel cap analogs. | 2010-10-14 |
20100261232 | MUTANT ALPHA-AMYLASES - Novel variant α-amylase enzymes are disclosed in which the residues corresponding to R179 and G180 in | 2010-10-14 |
20100261233 | L-LYSINE-PRODUCING CORYNEBACTERIA AND PROCESS FOR THE PREPARATION OF L-LYSINE - L-lysine-producing strains of | 2010-10-14 |
20100261234 | PROCESS FOR PRODUCING GLUTAMATE DERIVATIVES - The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same. | 2010-10-14 |
20100261235 | CONTINUOUS PRODUCTION OF BIODIESEL FUEL BY ENZYMATIC METHOD - A method for continuously producing a fatty acid ester of the present invention comprises (a) mixing and agitating an oil and fat starting material and a lower alcohol, and supplying a mixture to one of the catalyst reaction tubes filled with a lipase; (b) producing a fatty acid ester and glycerin in the catalyst reaction tube; (c) introducing an outflowing liquid from the catalyst reaction tube into a glycerin separation tank, thereby collecting the glycerin; (d) adding a lower alcohol to a separated liquid obtained by separating the glycerin from the outflowing liquid, mixing and agitating an obtained material, and supplying a mixture to a following catalyst reaction tube; (e) repeating the steps (b) to (d) until supply to a last catalyst reaction tube is performed; and (f) collecting a fatty acid ester from the separated liquid obtained from the last catalyst reaction tube. According to the method of the present invention, the concentration of a lower alcohol can be strictly controlled and by product glycerin can be automatically removed. | 2010-10-14 |
20100261236 | Genetically Stable Plasmid Expressing PDH and FDH Enzymes - Bi-cistronic plasmids used for the expression of formate dehydrogenase (FDH) and modified phenylalanine dehydrogenase (PDHmod) are provided. | 2010-10-14 |
20100261237 | FERMENTATIVE PRODUCTION OF ACETONE FROM RENEWABLE RESOURCES BY MEANS OF NOVEL METABOLIC PATHWAY - The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO | 2010-10-14 |
20100261238 | METHOD FOR PRODUCING SCYLLO-INOSITOL - It is intended to provide a novel NAD | 2010-10-14 |
20100261239 | METABOLICALLY ENGINEERED MICROORGANISM USEFUL FOR THE PRODUCTION OF 1,2-PROPANEDIOL - Microorganism useful for the production of 1,2-propanediol from a carbon source, wherein said microorganism is characterized by:
| 2010-10-14 |
20100261240 | METHOD OF PURIFYING ALCOHOL FROM A FERMENTATION BROTH - Method for purifying an alcohol, notably 1,3-propanediol, from a fermentation broth. | 2010-10-14 |
20100261241 | METHODS FOR THE PRODUCTION OF N-BUTANOL - Embodiments of the present invention include methods for the production of four carbon alcohols, specifically n-butanol, by a consolidated bioprocessing approach for the conversion of cellulosic material to the desired end product. According to some embodiments, recombinant microbial host cells are provided, preferably | 2010-10-14 |
20100261242 | STATIC SOLID STATE BIOREACTOR AND METHOD FOR USING SAME - A static solid state bioreactor and method of using same. The bioreactor comprises a vessel having an upper end and a lower end, the upper end having a sealable opening. A gas distribution system in communication with the upper end and the lower end of the vessel. A liquid distribution system in communication with the upper end of the vessel. A liquid recovery system in communication with the lower end of the vessel. A material removal system disposed at the lower end of the vessel for removing biomass from the vessel. | 2010-10-14 |
20100261243 | SYSTEM FOR RECYCLING WATER TO FACILITATE THE PRODUCTION OF ETHANOL - A system for the production of ethanol is disclosed. The system comprises a system for recycling water in an ethanol production process. The system may comprise: a water supply that supplies water to the ethanol production process, a cooling tower system that supplies water to the ethanol production process, and a treatment system that supplies water to the ethanol production process. The treatment system may be a reverse osmosis system that supplies a retentate stream to the ethanol production process. | 2010-10-14 |
20100261244 | METHOD FOR IMMOBILIZING BIO-MATERIAL ON TITANIUM DIOXIDE NANOPARTICLES AND TITANIUM DIOXIDE NANOPARTICLES IMMOBILIZED BY BIO-MATERIAL - There is provided a method for immobilizing a bio-material on a surface of titanium dioxide nanoparticles (TiO | 2010-10-14 |
20100261245 | LONG ACTING FORMULATION OF BIOPHARMACEUTICAL - The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation. | 2010-10-14 |
20100261246 | METHOD FOR INHIBITING TELOMERASE REACTION - An object of the present invention is to provide a method for inhibiting a DNA extension reaction by telomerase. | 2010-10-14 |
20100261247 | Active surface coupled polymerases - Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided. | 2010-10-14 |
20100261248 | Pharmaceutical Composition Comprising An Immunoglobulin FC Region as a Carrier - Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs. | 2010-10-14 |
20100261249 | RECOMBINANT C-TERMINAL ALPHA-AMIDATING ENZYME DERIVATIVE - Disclosed are: a recombinant C-terminal α-amidated enzyme derivative which lacks the formation of at least one disulfide bond among five disulfide bonds occurring in a C-terminal α-amidated enzyme derived from | 2010-10-14 |
20100261250 | Cyanide-Tolerant Nitrile Hydratases - Disclosed herein are cyanide-tolerant nitrile hydratases especially from | 2010-10-14 |
20100261251 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE - Two novel microorganisms, | 2010-10-14 |
20100261252 | METHODS OF ENHANCING YIELD OF ACTIVE IGA PROTEASE - The present disclosure relates in general to methods for recombinantly producing soluble, active IgA proteases (e.g., IgA1 proteases) in host cells (e.g., bacterial cells), and methods for using IgA proteases (e.g., IgA1 proteases) produced by the methods to treat IgA deposition disorders (e.g., IgA nephropathy). | 2010-10-14 |
20100261253 | Glucuronyl C5-Epimerase, DNA encoding the same and uses thereof - The invention is directed to a novel purified mouse C5-epimerase, fragments thereof, nucleic acids encoding the same and the recombinant production thereof. The invention is also directed to fragments of such epimerase, especially N-terminal fragments that are useful in fusion protein constructs to enhance the activity of recombinantly-produced heterologous epimerase enzymes. | 2010-10-14 |
20100261254 | BACULOVIRAL VECTORS COMPRISING REPEATED CODING SEQUENCES WITH DIFFERENTIAL CODON BIASES - The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors. | 2010-10-14 |
20100261255 | PROCESS, ADAPTED MICROBES, COMPOSITION AND APPARATUS FOR PURIFICATION OF INDUSTRIAL BRINE - Process for purifying brine including providing an aqueous brine solution comprising one or more inorganic salts, one or more organic compounds, and optionally one or more microbial nutrients other than microbial nutrients comprised in the one or more inorganic salts and the one or more organic compounds and conducting at least one unit operation for removing organic compounds from the aqueous brine solution provided in step (1) to obtain a first purified brine solution, wherein the at least one unit operation comprises contacting the aqueous brine solution with living microbes capable of oxidizing the organic compounds in the presence of oxygen. | 2010-10-14 |
20100261256 | NOVEL PROMOTER NUCLEIC ACID MOLECULE DERIVED FROM CORYNEBACTERIUM GLUTAMICUM, RECOMBINANT VECTOR COMPRISING THE PROMOTER, HOST CELL COMPRISING THE RECOMBINANT VECTOR AND METHOD OF EXPRESSING GENE USING THE HOST CELL - Provided are a novel promoter nucleic acid molecule having a nucleotide sequence of SEQ ID NO: 1 or 2 derived from | 2010-10-14 |
20100261257 | METHOD OF PRODUCTION OF L-AMINO ACIDS - An isolated polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, with the L-aspartic acid at position 5 of the amino acid sequence replaced by another proteinogenic amino acid, and possesses citrate synthase activity. In addition, a vector comprises the polynucleotide and a bacterium comprises the vector. An isolated polynucleotide comprises a nucleotide sequence comprising, from position 1 to 39, the nucleotide sequence corresponding to position 1 to 39 of SEQ ID NO: 11, from position 40 to 105, a nucleotide sequence encoding the amino acid sequence of SEQ ID NO: 12, with each proteinogenic amino acid except L-aspartic acid being present at position 5. A method of producing an L-amino acids is also described. | 2010-10-14 |
20100261258 | MODIFIED BACTERIOCINS AND METHODS FOR THEIR USE - Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of | 2010-10-14 |
20100261259 | Expression of Genes from Gram Negative Bacteria in Fungi - The present invention provides a method for the recombinant expression of polypeptides originating from gram negative bacteria, in a fungal host suitable for industrial production. In a first aspect the present invention relates to a method for recombinant expression of a polypeptide from a gram negative bacterium in a fungal host cell, comprising the steps: i) providing a nucleic acid sequence encoding the polypeptide, said nucleic acid sequence comprising a first nucleic acid sequence encoding a fungal signal peptide and a second nucleic acid sequence encoding the polypeptide, having at least one modified codon, wherein the modification does not change the amino acid encoded by said codon and the nucleic acid sequence of said codon is different compared to the corresponding codon in the wild type nucleic acid sequence present in the said gram negative bacterium; ii) expressing the modified nucleic acid sequence in the fungal host. | 2010-10-14 |
20100261260 | PHOTOBIOREACTOR AND METHOD FOR PROCESSING POLLUTED AIR - A photobioreactor ( | 2010-10-14 |