40th week of 2012 patent applcation highlights part 63 |
Patent application number | Title | Published |
20120252999 | PRODUCTION OF CHEMICAL COMPOUNDS - Systems and methods of producing chemical compounds are disclosed. An example chemical production system includes a combustion chamber having intake ports for entry of a gas mixture. An igniter ignites the gas mixture in the intake chamber to facilitate a reaction at a high temperature and high pressure. A nozzle restricts exit of the ignited gas mixture from the combustion chamber. An expansion chamber cools the ignited gas. The expansion chamber has an exhaust where the cooled gas exits the expansion chamber. A chemical compound product is formed in the expansion chamber. | 2012-10-04 |
20120253000 | Microcapsule and Methods of Making and Using Microcapsules - An embodiment of a microcapsule includes a shell surrounding a space, a liquid within the shell, and a light absorbing material within the liquid. An embodiment of a method of making microcapsules includes forming a mixture of a light absorbing material and an organic solution. An emulsion of the mixture and an aqueous solution is then formed. A polymerization agent is added to the emulsion, which causes microcapsules to be formed. Each microcapsule includes a shell surrounding a space, a liquid within the shell, and light absorbing material within the liquid. An embodiment of a method of using microcapsules includes providing phototriggerable microcapsules within a bulk material. Each of the phototriggerable microcapsules includes a shell surrounding a space, a chemically reactive material within the shell, and a light absorbing material within the shell. At least some of the phototriggerable microcapsules are exposed to light, which causes the chemically reactive material to release from the shell and to come into contact with bulk material. | 2012-10-04 |
20120253001 | Polyurethane-Based Sealant for Insulated Glass Units - Insulated glass units are sealed with polyurethane made using a natural oil-based polyol (NOBP). In one embodiment the NOBP is made using a monol-rich monomer containing high levels of mono-hydroxy functional fatty acid methyl esters. Insulated glass sealants based on these compounds provide enhanced resistance to UV and oxidative degradation as compared to conventional products while still providing the required barrier and mechanical properties. | 2012-10-04 |
20120253002 | BRANCHED POLYCARBONATE RESIN AND PROCESS FOR PRODUCING THE SAME - The invention seeks to provide a branched polycarbonate resin having a high branching agent content, which has a good melt tension, virtually causes no drawdown and permits stable molding when it is molded in extrusion molding, blow molding, injection molding, vacuum molding, etc., and a process for producing the same. | 2012-10-04 |
20120253003 | METHOD FOR PRODUCING LIQUID CRYSTAL POLYESTER - A method is provided for producing a liquid crystal polyester including: (1) polycondensing a mixture of a compound of formula (I) with a compound of formula (II) in a polymerization tank at 260 to 350° C. to form a prepolymer, wherein a ratio of by-products to be distilled off to the theoretical amount of by-products formed when the compound of formula (I) is polycondensed with the compound of formula (II) in a stoichiometric relation is 95% or more; (2) continuously discharging the prepolymer from the polymerization tank in a molten state, solidifying the prepolymer while transferring, and continuously grinding the solidified prepolymer by a grinder provided downstream in a transfer direction to produce prepolymer particles; and (3) heat-treating the prepolymer particles in their solid state under an inert gas atmosphere, thereby subjecting them to solid phase polymerization. | 2012-10-04 |
20120253004 | PROCESS FOR REMOVING METAL SPECIES IN THE PRESENCE OF HYDROGEN AND A POROUS MATERIAL AND POLYESTER POLYMER CONTAINING REDUCED AMOUNTS OF METAL SPECIES - Provided is a composition with partially aromatic polyester polymers having an It.V. of at least 0.50 dL/g, produced in an ester exchange melt phase process, having from zero or greater than zero to less than 5 ppm titanium, from zero or greater than zero to less then 10 ppm germanium, and from zero or greater than zero to less than 20 ppm manganese. | 2012-10-04 |
20120253005 | CONDITIONING OF DOUBLE METAL CYANIDE CATALYSTS - The invention relates to a method for conditioning double metal catalysts which are used in the production of polyether polyols. The conditioning enhances the performance of the catalyst, so that lower concentrations of the DMC catalyst can be used in polyether polyol production. | 2012-10-04 |
20120253006 | TWO HELIX BINDERS - Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders. | 2012-10-04 |
20120253007 | Synthesis of Cyclosporin H - A method of preparing purified cyclosporin H includes dissolving cyclosporin A in a first organic solvent and heating the first organic solvent in the presence of an acid catalyst; adding a base to the first organic solvent; recrystallizing cyclosporin H in a second solvent; and purifying the recrystallized cyclosporin H via chromatography to obtain purified cyclosporin H, while excluding recrystallizing the cyclosporin H in the presence of ether. In a further aspect, the method includes, after adding the base and before the recrystallizing, mixing the first organic solvent with a solvent more polar than the first organic solvent, separating the first organic solvent, and drying the first organic solvent. Cyclosporin H prepared as described herein was found to be biologically active, unlike that prepared using a previously-described method. | 2012-10-04 |
20120253008 | PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME - The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs. | 2012-10-04 |
20120253009 | THROMBOPOIETIC COMPOUNDS - The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal. | 2012-10-04 |
20120253010 | COMPOUND ACCUMULATING IN INFLAMMATORY SITE, DIAGNOSTIC AGENT CONTAINING THE COMPOUND IN LABELED STATE AND ITS PRECURSOR COMPOUND FOR LABELING - Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): | 2012-10-04 |
20120253011 | Native Chemical Ligation at Serine and Threonine Sites - A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (FIG. | 2012-10-04 |
20120253012 | METHOD FOR PREPARING LIPOPEPTIDE COMPOUND - There is provided a practical method for preparing lipopeptide compounds, which method is capable of inexpensive mass production without requiring complicated operations. The lipopeptide compound of formula (3): | 2012-10-04 |
20120253013 | Early Growth Transcription Factors and Their Therapeutic Use - The present invention comprises a nucleotide which encodes a protein, wherein the protein includes an amino acid sequence having at least 95% homology to SEQ ID NO: 1 (Egr3 DNA binding domain), for use in therapy. | 2012-10-04 |
20120253014 | PREVENTIVE AGENT FOR ATOPIC DERMATITIS - An object of the present invention is to provide a preventive agent for atopic dermatitis and food products containing the agent. The present inventors conducted extensive studies and, as the result, found that atopic dermatitis can be prevented by orally ingesting collagen. The present invention provides a preventive agent for atopic dermatitis comprising collagen and food products containing the preventive agent for atopic dermatitis. | 2012-10-04 |
20120253015 | SOY PROTEIN CONCENTRATE - In one embodiment a process for preparing a soy protein concentrate of good quality and yield from soybean white flakes without the need to screen out fines and dust from the soybeans white flakes before aqueous alcohol extraction is provided. The process includes extracting the soybean white flakes with hexane in a continuous counter current hexane extractor to remove the oil, partially stripping the hexane from the deoiled flakes under mild condition so as not to toast, cook or denature the protein, and without harsh mechanical handling, providing deoiled flakes, and delivering the flakes directly to an aqueous alcohol extractor to extract the residual hexane, sugars and other aqueous alcohol soluble material, to obtain a soy protein concentrate of good quality and yield. | 2012-10-04 |
20120253016 | ANTIBODY MOLECULES THAT BIND TO IL-6 RECEPTOR - The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions. | 2012-10-04 |
20120253017 | STEM CELL TARGETING - The present invention describes an antigen-binding construct comprising a first agent which binds to a stem cell specific marker molecule and a second agent which binds to a tissue specific marker molecule. In particular, the invention describes a construct wherein the tissue specific marker is a muscle specific marker molecule. Such a construct may be used in a pharmaceutical composition for use in muscle regeneration or heart disease. | 2012-10-04 |
20120253018 | Bovine Adeno-Associated Viral (BAAV) Vector and Uses Thereof - The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles. | 2012-10-04 |
20120253019 | NOVEL MONOCLONAL THYROID STIMULATING OR BLOCKING ANTIBODIES, PEPTIDE SEQUENCES CORRESPONDING TO THEIR VARIABLE REGIONS, AND THEIR USES IN DIAGNOSTIC, PREVENTIVE AND THERAPEUTIC MEDICINE - Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab′) | 2012-10-04 |
20120253020 | Compositions and Methods for Identifying Agents Which Modulate PTEN Function and PI-3 Kinase Pathways - Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling. | 2012-10-04 |
20120253021 | PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS - The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate. | 2012-10-04 |
20120253022 | METHOD OF REMOVING PROTEIN-BOUND DELETERIOUS SUBSTANCES DURING EXTRACORPOREAL RENAL REPLACEMENT TREATMENT - The invention is directed to a method of removing a deleterious substance bound to a protein in blood of a patient by introducing a displacer substance into the blood under conditions in which the displacer substance replaces deleterious substance bound to the protein, thereby resulting in additional unbound deleterious substance in the blood, and removing unbound deleterious substance from the blood by extracorporeal renal replacement treatment. | 2012-10-04 |
20120253023 | HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES - The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes. | 2012-10-04 |
20120253024 | METHOD AND SYSTEM FOR POLYPEPTIDE PURIFICATION - The present invention provides a method and automated system for the purification of polypeptides including the direct filtration of solutions containing the polypeptides after purification. | 2012-10-04 |
20120253025 | AZO COMPOUND AND METHOD OF PREPARING THE AZO COMPOUND - An azo compound having the following formula (I): | 2012-10-04 |
20120253026 | Expanding the Eukaryotic Genetic Code - This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided. | 2012-10-04 |
20120253027 | DETECTION OF MUTATIONS IN A GENE ASSOCIATED WTIH RESISTANCE TO VIRAL INFECTION, OAS1 - A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided. | 2012-10-04 |
20120253028 | METHOD FOR DEBLOCKING OF LABELED OLIGONUCLEOTIDES - The invention relates to a process for deblocking substantially a blocked, detectably labeled oligonucleotide by contacting the blocked detectably labeled oligonucleotide with an effective amount of a nucleophilic amino compound under conditions that result in substantial deblocking of the oligonucleotide, thereby giving the substantially deblocked oligonucleotide. | 2012-10-04 |
20120253029 | PROCESS FOR THE PREPARATION OF HIGHLY O-SULFATED EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE AND INTERMEDIATES THEREIN - A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives. | 2012-10-04 |
20120253030 | PROCESS FOR MANUFACTURING LOW-FIBRILLATING CELLULOSIC FIBER - A process for manufacturing low-fibrillating cellulosic fibers by a dry-jet-wet spinning process is provided. The cellulose is treated with a specific ionic liquid based solvent to produce the said fibers with fibrillating index less than or equal to (3). | 2012-10-04 |
20120253031 | PROCESS FOR MANUFACTURING LOW-FIBRILLATING CELLULOSIC FIBER - The present invention provides a process for producing low fibrillating cellulose fibers by a dry-jet-wet spinning process wherein cellulose is treated with a solvent containing imidazolium ionic salt in a spinneret maintained at a temperature of 100-120° C. and the spun fibers drawn to the coagulation bath containing ionic salt with the draw ratio less than 5, to produce fibers with fibrillating index less than or equal to 3. | 2012-10-04 |
20120253032 | NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids with short lipid chains that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo while decreasing inflammatory toxicities. | 2012-10-04 |
20120253033 | METHODS FOR SYNTHESIZING METAL MESOPORPHYRINS - Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. In embodiments, a metal mesoporphyrin compound may be formed directly from hemin without isolation of any intermediates. | 2012-10-04 |
20120253034 | PYRROLO[2,1-C][1,4]BENZODIAZEPINE LINKED IMIDAZO[1,5-A]PYRIDINE CONJUGATES AS POTENTIAL ANTITUMOUR AGENTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a compound of general formula 7, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine linked imidazo[1,5-a]pyridine conjugates attached through a piperazine moiety and different alkane spacers of general formula 7 | 2012-10-04 |
20120253035 | 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS - The present invention relates to 1,4 Oxazepines of formula I | 2012-10-04 |
20120253036 | AGENT FOR TREATING FIBROMYALGIA - An agent for treating fibromyalgia containing a 5-HT | 2012-10-04 |
20120253037 | METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE - Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine. | 2012-10-04 |
20120253038 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF - Efficient processes for the synthesis of pharmaceutically useful compounds such as (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate (Formula IX) using cyanomethoxybenzyl halides of Formula III, where X=Halogens e.g., Cl, F, Br, I; G=Any electron donating or electron withdrawing substituent. | 2012-10-04 |
20120253039 | Methods of Treating or Preventing Autoimmune Diseases with 2,4-Pyrimidinediamine Compounds - The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms. | 2012-10-04 |
20120253040 | OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY - Disclosed is a compound which is useful as an endothelial lipase inhibitor. | 2012-10-04 |
20120253041 | NEW PHENYLALANINE DERIVATIVES - Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin. | 2012-10-04 |
20120253042 | USE OF RUTHENIUM COMPLEXES FOR FORMATION AND/OR HYDROGENATION OF AMIDES AND RELATED CARBOXYLIC ACID DERIVATIVES - A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular hydrogen. Primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only byproduct) in high yields and high turnover numbers. Also disclosed are processes for hydrogenation of amides to alcohols and amines; hydrogenation of organic carbonates to alcohols; hydrogenation of carbamates or urea derivatives to alcohols and amines; amidation of esters; acylation of alcohols using esters; coupling of alcohols with water and a base to form carboxylic acids; dehydrogenation of beta-amino alcohols to form pyrazines and cyclic dipeptides; and dehydrogenation of secondary alcohols to ketones. These reactions are catalyzed by a Ruthenium complex which is based on a dearomatized PNN-type ligand of formula A1 or precursors thereof of formulae A2 or A3. | 2012-10-04 |
20120253043 | NOVEL LIGANDS FOR SENSITIZING DYES OF DYE-SENSITIZED SOLAR CELLS - The present invention provides new bi- and polypyridine ligands of ruthenium dyes. The invention also provides solar cells, in particular dye-sensitized solar cells comprising the dyes. | 2012-10-04 |
20120253044 | Boron Compounds and Uses Thereof - Organoboron compounds are described that upon exposure to light absorb light and isomerize and form a dark-colored isomer. The dark-colored isomer converts back to the colorless isomer upon removal of light, or exposure to oxygen or heat. Such compounds can be added into polymeric matrices such as films. These compounds are suitable for UV-blocking, UV-detecting, and for oxygen-sensing applications. Uses include UV-blocking windows, sunglasses, and as indicators in packaging such as food packaging. | 2012-10-04 |
20120253045 | Sulfur Containing Heterocycle-Fused Naphthalene Tetracarboxylic Acid Diimide Derivatives, Preparation Method And Use Thereof - Sulfur containing heterocycle-fused naphthalenetetracarboxylic acid diimide derivatives represented by formula (I) are disclosed, | 2012-10-04 |
20120253046 | PALONOSETRON METABOLITES - Provided are metabolites of palonosetron that can be used in treating animals, particularly humans, of the formula (I): or a pharmaceutically acceptable salt or prodrug thereof; wherein R | 2012-10-04 |
20120253047 | PROCESS FOR THE PREPARATION OF (R)-PRAMIPEXOLE - The invention relates to a novel process for the preparation of (R)-2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole, or a salt thereof. | 2012-10-04 |
20120253048 | RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE - Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases. | 2012-10-04 |
20120253049 | NOVEL HYDROGEN SULFATE SALT - The present invention relates to Compound 1 hydrogen sulfate salt and solvates, crystalline forms and amorphous forms thereof, and to processes for their preparation. | 2012-10-04 |
20120253050 | SYNTHESIS OF 8-AMINO BORON DIPYRROMETHENES HAVING BLUE FLUORESCENCE - A family of six 8-amino boron dipyrromethenes having Formulas 1, 2, 3, 4, 6, and 7 has been prepared. The presence of the amine group alters the emission properties of the boron dipyrromethene, such that these compounds are characterized by unexpected blue fluorescence, providing for potential use as lasers. The compound having formula 1 has very high quantum yield. The 8-amino boron dipyrromethenes are prepared in a straightforward, high yield synthesis by substituting an amine group for the thiomethyl group at the 8 position in 8-thiomethyl boron dipyrromethene. The compounds having Formulas 6 and 7 may be used to incorporate peptides and proteins, thus providing biomolecules marked with fluorescent fragments. | 2012-10-04 |
20120253051 | PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF - The present invention relates to an improved process for the preparation of Ropinirole and pharmaceutical acceptable salts or derivatives thereof, in particular to a process for large scale production of Ropinirole and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds. | 2012-10-04 |
20120253052 | METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF PORPHYRINS - A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: | 2012-10-04 |
20120253053 | POLYOXYALKYLENE-MODIFIED LIPID AND METHOD FOR PRODUCING THE SAME - Provided are a thiol-reactive polyoxyalkylene-modified lipid which can be used to chemically modify bioactive substances and which can be used for drug delivery systems such as liposomes and a method for producing the same. The polyoxyalkylene-modified lipid is represented by the following formula (1): | 2012-10-04 |
20120253054 | METHODS FOR PRODUCING OXIDIZED CYCLIC PHENOL SULFIDES - A method for producing an oxidized cyclic phenol sulfide which comprises the step of oxidizing a cyclic phenol sulfide of the following formula (1) as a raw material: | 2012-10-04 |
20120253055 | PROCESS FOR PREPARING DIVINYLARENE DIOXIDES - A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene; (b) at least one peroxycarboximidic acid; (c) at least one solvent; and (d) at least one basic compound, under conditions to form a reaction mixture containing a divinylarene dioxide product; and then separating the divinylarene dioxide product from the other reaction mixture components to obtain a purified divinylarene dioxide product. | 2012-10-04 |
20120253056 | OLEAGINOUS COMPOUNDS FROM BIOMASS - Disclosed herein are methods and processes for the recovery of oleaginous compounds from biomass and in particular biomass comprises photosynthetic microorganisms. Also disclosure are oleaginous compounds obtained using the disclosed methods. | 2012-10-04 |
20120253057 | Continuous Production Of Bioderived Esters Via Supercritical Solvent Processing Using Solid Heterogeneous Catalysts - A method for the continuous production of ester based organic compounds from renewable natural products via supercritical solvent processing in the presence of heterogeneous nano-structured catalysts. Fatty acid triglycerides may therefore be transesterified using heterogeneous nano-structured catalysts in the presence of supercritical alcohols to provide alkyl ester compounds and glycerine. | 2012-10-04 |
20120253058 | Manufacture of difluoroethylene carbonate, trifluoroethylene carbonate and tetrafluoroethylene carbonate - Difluoroethylene carbonate, trifluoroethylene and tetrafluoroethylene carbonate are produced by the reaction between elemental fluorine and ethylene carbonate or fluorinated ethylene carbonates with a lower degree of fluorination. | 2012-10-04 |
20120253059 | Hydroformylation Of Butenes - Mixed butene streams containing butene-1 and isobutylene and optionally butene-2 are hydroformylated under conditions that hydroformylates all the monomers to yield a mixture of valeraldehydes. Higher temperatures and/or longer residence times and/or higher partial pressure of carbon monoxide than in conventional processes are used to ensure hydroformylation of all the monomers. | 2012-10-04 |
20120253060 | METHOD FOR PRODUCING LIQUID CRYSTAL POLYESTER - Disclosed is a method for producing a liquid crystal polyester, which includes the steps of: | 2012-10-04 |
20120253061 | 3D IMAGE DISPLAY APPARATUS, METHOD OF MANUFACTURING THE SAME, PHASE DIFFERENCE PLATE, 3D IMAGE DISPLAY SYSTEM, AND ADHESIVE COMPOSITION FOR 3D IMAGE DISPLAY APPARATUS - A 3D image display apparatus has an image display panel portion that is driven based on image signals, and a phase difference plate that is disposed on an observation side of the image display panel portion and has at least a patterned optically anisotropic layer, in which the image display panel portion and the phase difference plate are adhered to each other through an adhesive composition having a glass transition temperature of room temperature or lower, and at least one of surfaces adhered through the adhesive composition is a film including a cellulose derivative. | 2012-10-04 |
20120253062 | METHOD FOR PRODUCING ALKYL 5-METHYL-5-HEXENOATE - A decarboxylation reaction of a (3-methyl-3-butenyl)malonic acid dialkyl ester, carried out by heating in the presence of water and a base, produces an alkyl 5-methyl-5-hexenoate. The decarboxylation reaction produces the alkyl 5-methyl-5-hexenoate inexpensively and effectively. The base can optionally be a tertiary amine compound or a heterocyclic amine compound. Producing the alkyl 5-methyl-5-hexenoate can optionally further include removing an alcohol. | 2012-10-04 |
20120253063 | PROCESS FOR PREPARING ISOCYANATES - Process for preparing aromatic isocyanates by reacting the corresponding formamides with an oxygen-comprising gas over noble metal catalysts at temperatures of from 300 to 600° C. and a contact time of from 1 to 1000 ms, wherein:
| 2012-10-04 |
20120253064 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE - To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds. | 2012-10-04 |
20120253065 | MANNICH CONDENSATION PRODUCTS USEFUL AS SEQUESTERING AGENTS - The present invention is directed to Mannich condensation product sequestering agents or mixtures of Mannich condensation product sequestering agents for use in fuels and lubricating oils. The present invention is also directed to a process for preparing the Mannich condensation product sequestering agents. The present invention is also directed to a product formed by combining, under reaction conditions, a polyisobutyl-substituted hydroxyaromatic compound, an aldehyde, an amino acid or ester thereof, and an alkali metal base to form the Mannich condensation product sequestering agent. The present invention is also directed to a lubricating oil composition, a lubricating oil concentrate, a fuel composition, and a fuel concentrate having the Mannich condensation product sequestering agents of the present invention. | 2012-10-04 |
20120253066 | PROCESS FOR THE PREPARATION OF CILASTATIN SODIUM - The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I), having mesityl oxide content less than 2000 ppm and more than 1 ppm. (Formula I) (I) | 2012-10-04 |
20120253067 | Catalyst System and Process for Converting Glycerol to Lactic Acid - A process for producing lactic acid from glycerol using a reaction mixture comprising glycerol, a dehydrogenation catalyst (preferably a copper-based catalyst), an alkaline component, and water. | 2012-10-04 |
20120253068 | PROCESS FOR PRODUCING METHIONINE - Provided is a process for producing methionine, which involves:
| 2012-10-04 |
20120253069 | METHOD FOR SEPARATION AND PURIFICATION OF LONG-CHAIN DIACIDS - A method for the separation and purification of at least one long-chain diacid, comprising:
| 2012-10-04 |
20120253070 | SURFACE MODIFIED MATERIAL, SULFONIMIDE COMPOUND FOR SURFACE MODIFICATION, AND FUEL CELL - There are provided a surface modified material comprising a base material, and one or more kinds of sulfonimide compound groups bonded onto the surface of the base material via one or more linking groups -A-Y′— (A is a direct bond or an organic group. Y′ is a bonding site with the base material.); the sulfonimide compound group comprising, in its molecular structure, one or more linking groups -A—Y′— and two or more sulfonimide groups; as well as a fuel cell using the surface modified material for a catalyst layer. There is also provided a sulfonimide compound for surface modification comprising one or more reactive end groups -A-Y (A is a direct bond or an organic group. Y is a reactive functional group.) and two or more sulfonimide groups. | 2012-10-04 |
20120253071 | Sterilization of biodegradable hydrogels - The present invention relates to a terminal sterilization process for biodegradable PEG-based insoluble hydrogels using irradiation. The presence of a protective solvent ensures that the hydrogel remains intact with functionally preserved three-dimensional and physicochemical properties. | 2012-10-04 |
20120253072 | PROCESS FOR THE PREPARATION OF AROMATIC FORMAMIDES - The invention relates to a process for the preparation of formamides by reacting aromatic amines with a formic acid ester in the presence of a catalyst, wherein the catalyst is a phosphorus-containing acid or a Lewis-acidic metal salt. | 2012-10-04 |
20120253073 | METHOD FOR PRODUCING OXIME - There is provided a method for producing an oxime compound, which is characterized by the steps of: | 2012-10-04 |
20120253074 | PROCESS FOR THE PREPARATION OF O-DESMETHYL-VENLAFAXINE AND SALTS THEREOF - The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV) and the pharmaceutically acceptable salts thereof, wherein it comprises (i) provision of spiro-venlafaxine compound as intermediate; (ii) conversion of spiro-venlafaxine intermediate into ODV free base in a one-pot process; and (iii) optionally conversion ODV free base into pharmaceutically acceptable salts. The present invention further relates to novel processes for the preparation of crystalline salts of OD V-succinate and ODV-oxalate. | 2012-10-04 |
20120253075 | METHOD FOR PRODUCING CARBON NANOMATERIALS AND/OR CARBON MICROMATERIALS AND CORRESPONDING MATERIAL - The present invention relates to a method for producing carbon nanomaterials and/or carbon micromaterials, in particular multi-wall carbon nanotubes. The method is characterized according to the invention in that at least one molecule that has a reactive group in terminal position is bound to the surface of the material. In addition, the invention also relates to a correspondingly modified material. | 2012-10-04 |
20120253076 | METHOD FOR PURIFYING COMPOUNDS CONTAINING AMINO GROUPS - Method for purifying compounds (I) containing amino groups from a polar phase A, where
| 2012-10-04 |
20120253077 | METHOD FOR DISTILLING MIXTURES COMPRISING ETHYLENEDIAMINE, N-METHYLETHYLENEDIAMINE, AND WATER, AND MIXTURES OF ETHYLENEDIAMINE AND N-METHYLETHYLENE-DIAMINE HAVING A LOW CONTENT OF N-METHYLETHYLENEDIAMINE OBTAINABLE THEREBY - The present invention relates to a mixture of ethylenediamine (EDA) and N-methyl-ethylenediamine (Me-EDA) with a low content of Me-EDA, which comprises at least 99.5% by weight of ethylenediamine, and wherein the concentration of N-methylethylenediamine is in the range from 0.005 to 0.15% by weight. | 2012-10-04 |
20120253078 | Agent for Improving Carcass Performance in Finishing Hogs - A food supplement for finishing hogs containing astaxanthin is described. | 2012-10-04 |
20120253079 | Use Of Steam To Reduce Coking And/Or Metal Dusting - The invention is directed towards the reduction of coke formation in furnaces. | 2012-10-04 |
20120253080 | Controlling the Normal:ISO Aldehyde Ratio in a Mixed Ligand Hydroformylation Process by Controlling the Olefin Partial Pressure - Control of an in-series, multiple, e.g., two, reaction zone, hydroformylation process for producing normal (N) and iso (I) aldehydes at a N:I ratio, the process comprising contacting an olefinically unsaturated compound, e.g., propylene, with carbon monoxide, hydrogen and a catalyst comprising (A) a transition metal, e.g., rhodium, (B) an organobisphosphite, and (C) an organomonophosphite ligand, the contacting conducted in first and subsequent reaction zones and at hydroformylation conditions comprising an olefinically unsaturated compound partial pressure in each zone, the control exercised by decreasing the olefinically unsaturated compound partial pressure in the first reaction zone to decrease the N:I ratio or increasing the olefinically unsaturated compound partial pressure in the first reaction zone to increase the N:I ratio. | 2012-10-04 |
20120253081 | Controlling the Normal:ISO Aldehyde Ratio in a Mixed Ligand Hydroformylation Process by Conrolling the Syngas Partial Pressure - A method of controlling a hydroformylation process for producing normal (N) and iso (I) aldehydes at a N:I ratio, the process comprising contacting an olefinically unsaturated compound, e.g., propylene, with synthesis gas and a catalyst comprising a transition metal, e.g., rhodium, and an organopolyphosphite and an organomonophosphite ligand, the contacting conducted at hydroformylation conditions comprising a synthesis gas partial pressure, the method comprising increasing the synthesis gas partial pressure in the first reaction zone to decrease the N:I ratio or decreasing the synthesis gas partial pressure in the first reaction zone to increase the N:I ratio. | 2012-10-04 |
20120253082 | METHOD OF PRODUCING DIOL OR TRIOL - A method for producing a diol or triol, which has a step of removing impurities contained in a diol- or triol-containing solution, is provided. In the method, a diol- or triol-containing solution is filtered through a nanofiltration membrane having a polyamide-containing functional layer. The diol- or triol-containing solution is then collected from the permeate flow of the nanofiltration membrane. | 2012-10-04 |
20120253083 | METHOD FOR PRODUCING DECANOLS BY MEANS OF HYDROGENATING DECENALS - The present invention relates to a method for producing at least one decanol by means of hydrogenating at least one decenal, wherein a first hydrogenation is carried out in the liquid phase on a solid first catalyst, wherein the first catalyst contains copper and nickel. The aim of the invention is to provide a method of the type mentioned above, according to which decenals can be hydrogenated into decanols in high yields even after long operating periods. The content of non-reacted decenals in the hydrogenation discharge in particular should be less than 1500 ppm. Said aim is achieved by carrying out the hydrogenation in two steps, which is to say in a first step in a known manner using a catalyst comprising copper, nickel and optionally chromium and/or barium oxide, and subsequently in a second step using a different catalyst that must be free of copper, chromium and nickel. | 2012-10-04 |
20120253084 | VENT SCRUBBERS FOR USE IN PRODUCTION OF ETHANOL - A process for producing ethanol comprising the steps of hydrogenating an acetic acid feed stream to form a crude ethanol product and separating at least a portion of the crude ethanol product to form an ethanol stream and at least one vent stream. The vent stream comprises non-condensable gases at least one volatile organic. The process further comprises the step of scrubbing the vent stream with at least two different solvents to recover the volatile organics. The vent stream may also comprise entrained ethanol, which may also be recovered. | 2012-10-04 |
20120253085 | Ethanol Production from Acetic Acid Utilizing a Molybdenum Carbide Catalyst - A process for the selective and direct formation of ethanol from acetic acid comprising contacting a feed stream containing acetic acid and hydrogen in vapor form at an elevated temperature with a hydrogenation catalyst comprising molybdenum carbide and one or more promoter metals selected from the group consisting of copper, iron, cobalt, nickel, ruthenium, rhodium, palladium, osmium, iridium, platinum, titanium, zinc, chromium, rhenium, potassium, tin and tungsten on a catalyst support | 2012-10-04 |
20120253086 | METHOD OF PRODUCING BUTANOL - A method of producing butanol, which has a step of removing impurities contained in a butanol-containing solution, is provided. In the method, a butanol-containing solution is filtered through a nanofiltration membrane. Then the butanol-containing solution is collected from the permeate flow of the nanofiltration membrane. | 2012-10-04 |
20120253087 | Catalytic Isomerisation of Linear Olefinic Hydrocarbons - Gallium-niobium oxide catalysts are disclosed herein for converting linear olefinic hydrocarbons to branched olefinic hydrocarbons through isomerisation, the latter being capable for use fuel for their desirable properties. | 2012-10-04 |
20120253088 | METHODS AND COMPOSITIONS FOR PRODUCING OLEFINS - Compositions and methods for producing olefins are described herein. The olefins can be used to produced biofuels. | 2012-10-04 |
20120253089 | PROCESS FOR THE CONVERSION OF LOWER ALKANES TO AROMATIC HYDROCARBONS - The present invention provides a process for producing aromatic hydrocarbons which comprises: (a) alternately contacting a lower alkane feed with an aromatization catalyst under aromatization reaction conditions in a reactor for a short period of time, preferably 30 minutes or less, to produce aromatic reaction products and then contacting the aromatization catalyst with a hydrogen-containing gas at elevated temperature for a short period of time, preferably 10 minutes or less, (b) repeating the cycle of step (a) at least one time, (c) regenerating the aromatization catalyst by contacting it with an oxygen-containing gas at elevated temperature and (d) repeating steps (a) through (c) at least one time. | 2012-10-04 |
20120253090 | SPHERICAL ZEOLITIC CATALYST FOR CONVERTING METHANOL INTO OLEFINS - A catalyst containing a pentasil-type alumosilicates and a binder, in the form of spheres having an average diameter between 0.3 and 7 mm, wherein the BET surface area of the catalyst ranges from 300 to 600 m | 2012-10-04 |
20120253091 | METHOD FOR MAKING HYDROCARBONS BY USING A LIPID DERIVED FROM A BIOLOGICAL ORGANISIM AND HYDROTALCITE - The present invention relates to a method in which a catalytic reaction is used in order to produce hydrocarbons from renewable starting material derived from biological organisms such as vegetable lipids, animal lipids, and lipids extracted from macroalgae and microalgae, and more specifically relates to a method for selectively making a hydrocarbon, which is suitable for making gasoline or diesel, by removing the oxygen contained in the starting material without consuming hydrogen. In the present invention, the production takes place by bringing the starting material into contact with hydrotalcite, which constitutes a catalyst, thereby removing oxygen via a decarboxylation or decarbonylation reaction; and the starting material is one or more such material selected from triglycerides, fatty acids, and fatty acid derivatives obtained from a renewable source of supply originating from a biological organism. | 2012-10-04 |
20120253092 | METHOD AND SYSTEM FOR REMOVAL OF FOULANT PRECURSORS FROM A RECYCLE STREAM OF AN OLEFINS CONVERSION PROCESS - A post fractionation process for removing heavy hydrocarbons from the C | 2012-10-04 |
20120253093 | METHOD OF ALKYLATION USING CATALYST ON CERAMIC FOAM SUPPORT - This invention relates to an alkylation catalyst, a method for preparing the alkylation catalyst, and a method for alkylating olefins and paraffins. The alkylation catalyst includes a foam catalyst support wherein active catalyst particles have been appended to the surface of the foam support. | 2012-10-04 |
20120253094 | STABILIZING HAZARDOUS WASTES USING WASTE BYPRODUCTS - A method of disposing of two or more waste materials, including at least one hazardous waste material, which method includes the steps of: obtaining a waste byproduct; producing a reagent from the waste byproduct which reagent includes one or more contaminates; obtaining a waste material containing one or more hazardous heavy metals; treating the hazardous heavy metal containing waste material with the reagent from step b) to stabilize the hazardous heavy metal containing waste material; and disposing of the stabilized hazardous heavy metal containing waste material. According to one embodiment the waste byproduct is gypsum. The gypsum can be obtained from a flue gas desulfurization process. According to another embodiment the waste byproduct is a calcium carbonate containing byproduct which is reacted with acid tar to produce calcium sulfide. The calcium carbonate containing byproduct can come from a Solvay process. | 2012-10-04 |
20120253095 | CREATING A COMPENSATOR FROM SOLID PARTICULATES - A patient-specific compensator is created from solid particulates on-site at a radiation treatment facility and then used there at that facility in conjunction with a radiation therapy machine to deliver radiation therapy to a cancer patient. After use, the compensator can be broken down into loose solid particulates at the facility, and another compensator can be created on-site at the facility from those particulates and used in the radiation treatment of a different cancer patient at the facility. | 2012-10-04 |
20120253096 | RADIATION THERAPY APPARATUS AND CONTROL METHOD - According to one embodiment, a radiation therapy apparatus includes a radiation irradiation device, a detector included in a PET scanner, a control unit, and a PET image reconstruction unit. The radiation irradiation device emits a therapeutic radiation. The detector counts light derived from gamma rays, and is provided with a gap portion through which the therapeutic radiation passes on a plane of rotation about the body axis of a subject. The control unit controls the radiation irradiation device and the detector so as to rotate in synchronization with each other in a state capable of emitting the therapeutic radiation to the gap portion. The PET image reconstruction unit reconstructs a PET image based on position information at the time of counting of the detector that nearly coincidentally counts pair annihilation gamma rays in a state where the control unit performs rotation control. | 2012-10-04 |
20120253097 | DEVICE SYSTEM AND METHOD FOR TISSUE DISPLACEMENT OR SEPARATION - A tissue displacement/separation device is provided. The device includes a bladder which is expandable between a first tissue and a second tissue of a body. The bladder has an expanded shape which is selected capable of displacing or separating the first tissue from the second tissue in a manner suitable for protecting the first tissue from an effect of a treatment applied to the second tissue. | 2012-10-04 |
20120253098 | PULSED ELECTROMAGNETIC ENERGY TREATMENT APPARATUS AND METHOD - An apparatus and method for the treatment of chronic wounds using electromagnetic energy. The apparatus includes a generator and at least one applicator. The generator can produce electromagnetic energy and the applicator can apply the electromagnetic energy produced by the generator. A detector is disposed on the applicator that can measure the field strength of the electromagnetic energy applied. | 2012-10-04 |