39th week of 2012 patent applcation highlights part 48 |
Patent application number | Title | Published |
20120245010 | FORMING SHOULDER AND DEVICE FOR PRODUCING TUBULAR BAGS - In a method for producing tubular bags, a forming shoulder for shaping a packaging material web into a tubular bag having a laterally offset longitudinal seam includes a shoulder party and a prism part connected to each other along a shaping edge. Half of the shaping edge facing the incoming packing material web lies in the first and second quadrants of the cross-section of the prism part and the seam is formed in the fourth quadrant. Curvature-free surface lines in the second and fourth quadrants originating from the shaping edge approach each other with increasing distance from the prism part, and the shaping edge angle measured between the surfaces of the shoulder part and the inner face of the prism part decreases from the second to the third quadrant and increases again from the third to the fourth quadrant. | 2012-09-27 |
20120245011 | STRUCTURE OF PAPER CONVERTING MACHINE - A paper converting or rewinding machine provides a cutting or perforation section, equipped with at least one blade arranged to work in combination with a stationary knife to provide the division of the web of paper into a plurality of sheets of measured length. The blade can be integral to a fixed support, or alternatively to a cutting roller that rotates about a longitudinal rotation axis. The blade(s) can be a perforation blade, or a cutting blade, with helical shape, and mounted to a perforation roller. The stationary knife can be mounted to a fixed roller. The blade performs a cutting, or perforation, of the web into sheets working in combination with the stationary knife. The blades and the stationary knifes are long substantially as the width of the paper. In particular, the blade has at least one weakened portion of determined size. | 2012-09-27 |
20120245012 | SHEET PROCESSING APPARATUS - The sheet processing apparatus processes a sheet having an image formed thereon by an image forming apparatus. The sheet processing apparatus includes a sheet folding unit for folding the sheet having an image formed thereon, a sheet tray loaded with the sheet folded by the sheet folding unit to be taken out, and a control unit for controlling the sheet processing apparatus as a whole. The sheet tray includes a mechanism capable of adjusting an angle with a virtual plane and a detection device detecting a change of the angle with the virtual plane. The control unit prohibits ejection from the sheet folding unit to the sheet tray, based on the detection result of the detection device and the content of the folding processing by the sheet folding unit. | 2012-09-27 |
20120245013 | SPINNING DISC CENTRIFUGE ROTOR - The spinning disc centrifuge rotor includes a sample holder formed from a cylindrical disc body and a cover plate that are made from a transparent material, such as polycarbonate, preferably Lexan® (Lexan is a registered trademark of General Electric Company of Schenectady, N.Y.). The disc-shaped body has two concentric or coaxial recesses defined therein. The first recess forms a cylindrical well or sample chamber for receiving a generally cylindrical rock sample. The second recess has a larger diameter than the first recess, and is shallower, forming a fluid collection area above the sample well, the second recess forming an annular ring extending around the top edge or rim of the sample well. An O-ring snugly within the outer wall of the second recess and forms a seal between the cover plate and the floor of the second recess, preventing fluid leakage. A rotor shaft extends from the bottom face of the cylindrical disc. | 2012-09-27 |
20120245014 | APPARATUSES AND METHODS OF MANUFACTURING OILFIELD MACHINES - A centrifuge, including a bowl having a composite material, a screw conveyor rotatably mounted within the bowl, and a feed pipe mounted within the screw conveyor for feeding a drilling mud through a feed port in a wall of the screw conveyor to an annular space between the bowl and the wall of the screw conveyor. Also, a method of replacing a centrifuge component, including removing the centrifuge component and installing a new centrifuge component, where the centrifuge components include a bowl and a screw conveyor rotatably mounted within the bowl, and where the new centrifuge component includes a composite material. | 2012-09-27 |
20120245015 | OPTICAL GLASS, GLASS MATERIAL FOR PRESS MOLDING, OPTICAL ELEMENT BLANK, OPTICAL ELEMENT AND MANUFACTURING METHOD THEREOF - A fluorophosphate glass containing: P | 2012-09-27 |
20120245016 | HIGH DIELECTRIC CONSTANT COMPOSITE MATERIALS AND METHODS OF MANUFACTURE - The present invention relates to composite materials with a high dielectric constant and high dielectric strength and to methods of producing the composite materials. The composite materials have high dielectric constants at a range of high frequencies and possess robust mechanical properties and strengths, such that they may be machined to a variety of configurations. The composite materials also have high dielectric strengths for operation in high power and high energy density systems. In one embodiment, the composite material is composed of a trimodal distribution of ceramic particles, including barium titanate, barium strontium titanate (BST), or combinations thereof and a polymer binder. | 2012-09-27 |
20120245017 | Method and Electrochemical Cell for Synthesis and Treatment of Metal Monolayer Electrocatalysts Metal, Carbon, and Oxide Nanoparticles Ion Batch, or in Continuous Fashion - An apparatus and method for synthesis and treatment of electrocatalyst particles in batch or continuous fashion is provided. In one embodiment, the apparatus comprises a sonication bath and a two-compartment chamber submerged in the sonication bath. The upper and lower compartments are separated by a microporous material surface. The upper compartment comprises a cover and a working electrode (WE) connected to a Pt foil contact, with the foil contact connected to the microporous material. The upper chamber further comprises reference counter electrodes. The lower compartment comprises an electrochemical cell containing a solution of metal ions. In one embodiment, the method for synthesis of electrocatalysts comprises introducing a plurality of particles into the apparatus and applying sonication and an electrical potential to the microporous material connected to the WE. After the non-noble metal ions are deposited onto the particles, the non-noble metal ions are displaced by noble-metal ions by galvanic displacement. | 2012-09-27 |
20120245018 | High aspect ratio nanoscale multifunctional materials - The present invention discloses high aspect ratio multifunctional nanocomposite of CNF/polymer comprising of functionalized CNF incorporated with metal nanoparticles and phosphoric acid doped polybenzimidazole (PBI) along the inner and outer surfaces of hollow carbon nanofiber and to a process for fabrication of the same thereof. | 2012-09-27 |
20120245019 | Method and Electrochemical Cell for Synthesis of Electrocatalysts by Growing Metal Monolayers, or Bilayers and Treatment of Metal, Carbon, Oxide and Core-Shell Nanoparticles - An apparatus and method for the synthesis and treatment of electrocatalyst particles in batch or continuous fashion is provided. In one embodiment, the apparatus is comprised of a three-electrode cell which includes a cell body electrode, a reference electrode, and a counter electrode. A slurry containing non-noble metal ions and a plurality of particles is introduced into the apparatus. During operation an electrical potential is applied and the slurry is stirred. When particles in the slurry collide with the electrically conductive region of the cell body electrode the transferred charge facilitates deposition of an adlayer of the desired metal. In this manner film growth can commence on a large number of particles simultaneously. After the non-noble metal ions are deposited onto the particles, they are displaced by noble-metal ions by galvanic displacement. This process is especially suitable for forming catalytically active layers on nanoparticles for use in energy conversion devices. | 2012-09-27 |
20120245020 | ABSORBENT ARTICLES AS CARBON SINKS - An absorbent article such as, for example, a diaper, a sanitary napkin, a panty liner or a male or female incontinence article. The article includes inorganic material. The inorganic material includes carbon which is derived from atmospheric carbon dioxide. Methods for making the absorbent articles are also provided. | 2012-09-27 |
20120245021 | Polyolefins Prepared from a Metallocene and a New Single Site Catalyst Components in a Single Reactor - The present invention discloses a catalyst system based on a metallocene catalyst component and a new single site catalyst component for the production in a single reactor of improved polyolefins having a bimodal molecular weight distribution. | 2012-09-27 |
20120245022 | Processes for Making Tin-Containing Catalysts - A process for producing a catalyst comprising the steps of contacting a support with a mixed metal precursor comprising tin oxalate, a second metal precursor, a solubilizing agent such as ammonium oxalate, and water to form an impregnated support and heating the impregnated support under conditions effective to remove at least a weight majority of the water and reduce the tin from the tin oxalate and the second metal from the second metal precursor and thereby form the catalyst. | 2012-09-27 |
20120245023 | IRREGULARLY SHAPED NON-SPHERICAL SUPPORTED CATALYST, AND A PROCESS FOR HYDROCONVERSION HEAVY OIL FRACTIONS - A catalyst for hydrotreating and/or hydroconverting heavy metal-containing hydrocarbon feeds, comprises a support in the form of mainly irregular and non-spherical alumina-based agglomerates the specific shape. The catalyst is prepared by a specific order of steps: crushing, calcining, acidic autoclaving, drying, further calcining and impregnation with catalytic metals. | 2012-09-27 |
20120245024 | METHOD FOR MANUFACTURING A CATALYST SUPPORT - A method for manufacturing a catalyst support, includes, in the following order, the steps of: (a) shaping a non-sintered porous ceramic base support; (b) depositing, on at least part of the surface of the non-sintered porous ceramic base support, a suspension of ceramic powder in a solvent or a mixture of solvents so as to form an interface layer able to increase the surface area of the base support; (c) sintering the base support, at least partially coated with the suspension. This method allows to economically and rapidly manufacture catalyst supports, and especially burners for fragrance diffuser. | 2012-09-27 |
20120245025 | SULFUR CONTAINING SILICA PARTICLE - A silica-containing composition is disclosed. The composition comprises a compound having the following formula: (SiO | 2012-09-27 |
20120245026 | SPIRO FUSED 1-AMINO - PIPERDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY - Compounds of the formula (I) wherein the substituents are as defined in claim | 2012-09-27 |
20120245027 | MICROCAPSULES WITH ACETYLENE CARBAMIDE-POLYUREA POLYMERS AND FORMULATIONS THEREOF FOR CONTROLLED RELEASE - The present Invention deals with an alternative Interfacial polymerization process of microencapsulation, microcapsule's produced thereof, microencapsulated agrochemicals, pharmaceuticals, catalysts and phase transfer materials, and formulations thereof, by means of microcapsules and starting materials with the participation of acetylene carbamide derivatives in the final structure of the microcapsules' wall. | 2012-09-27 |
20120245028 | Methods for Use of Tetraalkyl Ammonium Halide Compositions as Post-emergence Higher Plant Herbicides - Tetraalkyl ammonium halides are applied to a broad range of undesirable terrestrial plants for fast and effective herbicidal activity. It is desirable to use a herbicidally effective amount of the chemical formula R | 2012-09-27 |
20120245029 | NOVEL PHOSPH(ON)ATE- AND SULF(ON)ATE-BASED PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS - This invention provides phosphate-modified nucleosides represented by the structural formula (I): wherein W is O or S, and wherein B, R | 2012-09-27 |
20120245030 | HERBICIDE COMPOSITION - The invention provides a herbicide composition having a remarkable effect on controlling weeds which comprises N-(7-fluoro-3,4-dihydro-3-oxo-4-prop-2-ynyl-2H-1,4-benzoxazin-6-yl)cyclohex-1-ene-1,2-dicarboxamide and an inert carrier, wherein the N-(7-fluoro-3,4-dihydro-3-oxo-4-prop-2-ynyl-2H-1,4-benzoxazin-6-yl)cyclohex-1-ene-1,2-dicarboxamide has a volume median diameter of 1.7 μm or less. | 2012-09-27 |
20120245031 | Pesticidal Mixtures - The present invention relates to an agrochemical mixture for increasing the health of a plant comprising as active ingredients
| 2012-09-27 |
20120245032 | AGRICULTURE ACTIVES DELIVERY COMPOSITION COMPRISING BORON AND PERSULFATE ION-CROSSLINKED POLYVINYL ALCOHOL MICROCAPSULES AND METHOD OF USE THEREOF - An aqueous composition is provided having a pH of from about 2.0 to about 12.8 and comprising boron or persulfate ion-crosslinked polyvinyl alcohol microcapsules. A method of delivering an agriculture active to a substrate is further provided comprising applying to the substrate an aqueous composition comprised of agriculture active containing, boron or persulfate ion-crosslinked, polyvinyl alcohol microcapsules, as well as a method of treating a substrate to protect from pests or promote crop growth comprising applying to the substrate an aqueous treating composition comprised of agriculture active containing, boron or persulfate ion-crosslinked, polyvinyl alcohol microcapsules. | 2012-09-27 |
20120245033 | TERMINAL STRUCTURE OF SUPERCONDUCTING CABLE SYSTEM - A superconducting cable terminal connection device connecting a terminal of a superconducting cable for power transmission to an external power system, includes: an electric field relaxation shield disposed inside an insulation housing; a horizontal conductor fixed to an end portion of a core of the superconducting cable drawn into the electric field relaxation shield; an insulator which coats an outer periphery of the horizontal conductor; a vertical conductor which is drawn into the electric field relaxation shield and has a through-hole through which the horizontal conductor and the insulator pass so as to be slidable in a lengthwise direction; and a flexible electrical conduction member which electrically connects an end portion of the horizontal conductor to the vertical conductor. | 2012-09-27 |
20120245034 | LOW AC-LOSS MULTI-FILAMENT SUPERCONDUCTING WIRE MATERIAL AND MANUFACTURING METHOD THEREFOR - A low AC-loss multi-filament superconducting wire material of the invention includes an elongated base material, an intermediate layer formed on the base material; a superconducting layer formed on the intermediate layer, and a metal stabilizing layer formed on the superconducting layer, wherein a plurality of grooves extending along a long direction of the base material is formed in parallel in a width direction of the base material, and reach the intermediate layer from the metal stabilizing layer via the superconducting layer to expose the intermediate layer; and a difference δd (=d | 2012-09-27 |
20120245035 | MITIGATING THE EFFECTS OF DEFECTS IN HIGH TEMPERATURE SUPERCONDUCTOR WIRES - A method includes locating a defect in a first segment of high temperature superconducting wire. A second segment of high temperature superconducting wire is then positioned onto the first segment of high temperature superconducting wire such that the second segment of high temperature superconducting wire overlaps the defect. A path is then created such that current flows through the second segment of high temperature superconducting wire. The first segment of high temperature superconducting wire and second segment of high temperature superconducting wire are then laminated together. | 2012-09-27 |
20120245036 | SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION HOSTS - The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization. | 2012-09-27 |
20120245037 | RESTRICTION ENZYME BASED WHOLE GENOME SEQUENCING - Method for de novo whole genome sequencing based on a (sequence-based) physical map of a DNA sample clone bank based on end-sequencing tagged adapter-ligated restriction fragments, in combination with sequencing adapter-ligated restriction fragments of the DNA sample wherein the recognition sequence of the restriction enzyme used in the generation of the physical map is identical to at least part of the recognition sequence of the restriction enzyme used in the generation of the DNA sample. | 2012-09-27 |
20120245038 | THERMAL CYCLING APPARATUS AND METHOD - A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent. | 2012-09-27 |
20120245039 | Entangled Mate Sequencing - Methods and compositions are provided for performing a set of N DNA sequencing reaction cycles whereby sequence information is obtained for approximately 2*N nucleotide bases. | 2012-09-27 |
20120245040 | METHODS FOR SYNTHESIS OF ENCODED LIBRARIES - The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. | 2012-09-27 |
20120245041 | BASE-BY-BASE MUTATION SCREENING - Aspects of the present invention are drawn to screening assays for isolating polynucleotides having a sequence variation or mutation. Embodiments of the screening assays include generating a population of polynucleotide duplexes having 5′ overhang regions on one strand of the duplex (the “template” or “bottom strand”) followed by isolating polynucleotide duplexes from the mixture that have one or more mismatched base at the 3′ end of the other strand of the duplex (the “test” or “top” strand). | 2012-09-27 |
20120245042 | DEBUBBLER FOR MICROFLUIDIC SYSTEMS - Provided are robust, passive, membrane-based debubblers that are readily incorporated into microfluidic devices for rapid degassing. Also provided are methods of degassing fluid disposed within fluidic systems. | 2012-09-27 |
20120245043 | SYSTEMS AND METHODS FOR DETECTING AND IDENTIFYING CONTAMINANTS IN A GASEOUS ENVIRONMENT - A method for identifying a contaminant in an environment includes providing a sensor array, the sensor array including a plurality of sensing platforms, each of the sensing platforms including a corrodible metal. A reaction is detected on the corrodible metal on one or more of the sensing platforms to identify a reaction pattern, and the reaction pattern is compared to known reaction characteristics of the corrodible metals. Based on this comparison, the contaminant, such as a corrosive gas, can be identified. The sensing platform may include a quartz crystal microbalance or a nanostructure. In some features, at least one of the corrodible metals includes gold, and a detected reaction of the gold corrodible metal indicates the presence of adverse temperature or humidity conditions in the environment. | 2012-09-27 |
20120245044 | METHODS OF DETERMINING CHEMOTHERAPY RESPONSE IN CANCER - This disclosure provides a biomarker profile, which is linked to cancer cell chemo-resistance. The disclosure further provides methods of diagnosis and theranosis, and screening of new therapeutic agents using these biomarkers in the profile, and kits for employing these methods and compositions. | 2012-09-27 |
20120245045 | METHODS AND KITS TO IDENTIFY INVASIVE GLIOBLASTOMA - The invention encompasses methods and kits used in the detection of invasive glioblastoma based upon the expression of NHERF-1. The methods and kits also allow prediction of disease outcome as well as therapeutic outcome. | 2012-09-27 |
20120245046 | GENE EXPRESSION PROFILING FROM FFPE SAMPLES - Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and implemented as well as used to augment diagnosis and treatment of diseases. | 2012-09-27 |
20120245047 | DEVICE AND METHODS FOR MOLECULAR ANALYSIS - Systems and methods are provided for high speed sorting of objects in a continuous body of fluid. The object can be analyzed within one or more interrogation volumes that allow for simultaneous or time-correlated measurement of the object's properties. A processor can interpret the properties of the object and then measured and then direct the object to one of a plurality of downstream flow paths. In some embodiments, the sorting of the object is based on two or more properties of the object. The sorting process can be repeated to create a network of sorting events. | 2012-09-27 |
20120245048 | CELLULAR RESPONSE ASSAY FOR BIOFLUID BIOMARKER DISCOVERY AND DETECTION - The invention provides a method to detect an abnormal condition or disease state by assessing a characteristic response pattern of responder cells to indicators contained in a biological fluid of a subject. A characteristic disease-associated pattern can be obtained by determining the response pattern of responder cells to that of bodily fluids or fractions thereof from subjects known to exhibit a particular abnormal condition optionally comparing said pattern to such pattern elicited by fluids or fractions from normal subjects and identifying elements that differ. The identified elements constitute a characteristic or differential pattern which can then be used to identify the presence or stage of a disease in a test subject. | 2012-09-27 |
20120245049 | System and Method for Pixelated Fluid Assay - A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active nature of the pixel, remotely requesting from the pixel's sensor assay site an assay-result output report. The method further includes, in relation to the employing step, creating, relative to the sensor's assay site in the at least one pixel, a predetermined, pixel-specific electromagnetic field environment. | 2012-09-27 |
20120245050 | BIOMARKER FOR PREDICTING THERAPEUTIC EFFICACY OF ALLERGEN IMMUNOTHERAPY - [Problem] To provide a biomarker for predicting the therapeutic efficacy of allergen immunotherapy. | 2012-09-27 |
20120245051 | OBJECTIVE, QUANTITATIVE METHOD TO PREDICT HISTOLOGICAL SUBTYPE IN NON-SMALL CELL LUNG CANCER - The invention provides a method for determining the histotype of a non-small cell lung cancer tumor which comprises: (a) determining the levels of expression of each of thyroid transcription factor-1, cytokeratin-5, cytokeratin-13 and epidermal growth factor receptor in a sample from the non-small cell lung cancer tumor; (b) calculating a score based on the levels of expression determined in step (a); and (c) comparing the score obtained in step (b) with a predetermined reference score associated with histotypes of non-small cell lung cancer; wherein the tumor is determined to be an adenocarcinoma if the score obtained in (b) is greater than the predetermined reference score and wherein the tumor is determined to be a squamous cell carcinoma if the score obtained in (b) is less than the predetermined reference score. | 2012-09-27 |
20120245052 | SYSTEM AND METHOD FOR ANALYZING DNA MIXTURES - Provided is a method for determining the presence or absence of an individual's DNA in a sample containing DNA from two or more contributors. A panel of a plurality of single nucleotide polymorphisms (SNPs) is used. For each SNP in the panel, it is determined whether the minor allele of the SNP is present in the sample, and whether the minor allele is present in the individual's DNA. If the number of minor alleles that are present in the individual's DNA that are also present in the DNA sample is above a predetermined threshold, the individual's DNA is concluded to be present in the sample. Also provided is an array of DNA molecules for use in the method, as well as a method for estimating the number of individuals contributing to a DNA containing sample. | 2012-09-27 |
20120245053 | GENE EXPRESSION ANALYSIS METHOD USING TWO DIMENSIONAL cDNA LIBRARY - The present invention provides a method and/or means for collecting and analyzing an individual cell in a tissue, and at the same time, quantitatively monitoring the expression levels of various genes while keeping two-dimensional information in the tissue. Specifically, the present invention provides a method comprising preparing a cDNA library from mRNA while keeping two-dimensional cellular distribution information and obtaining the gene expression levels at any site or all sites at a level of single cell. More specifically, the present invention provides a method comprising preparing a cDNA library in a sheet-form from mRNA while keeping two-dimensional cellular distribution information and repeatedly using the cDNA library in the detection of the gene expression, thereby allowing measurement of the expression distribution for a number of genes at a high accuracy. | 2012-09-27 |
20120245054 | High-Throughput Assay for Sugar-Mediated Drug Transport - The invention provides a rapid, quantitative assay to directly assess the impact of a diverse range of sugars upon the sugar-mediated uptake of corresponding sugar-conjugates into various cell types. | 2012-09-27 |
20120245055 | Method for Assembly of Analyte Filter Arrays Using Biomolecules - Analyte filter arrays and methods for making an analyte filter array are provided. The arrays are formed using a dispersion of filter particles having selected moieties attached to the surface of the particles and a microarray having complementary moieties formed in an array on a substrate, such that each filter particle is attached to a selected region of the microarray. The moiety on the substrate may be RNA or DNA or other molecule. The substrate may be a surface of a detector array, a membrane that may be placed in registration with the detector array or a stamp used to transfer the filter array to a detector array. | 2012-09-27 |
20120245056 | COMPOSITIONS AND METHODS FOR THE SAME ASSEMBLY OF POLYNUCLEOTIDES - The present invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides. The methods of the invention utilize circular nucleic acid vectors that comprise a DNA segment D flanked by an annealable linker sequence, annealable linker sequence pairs LA and LB, or annealable linker sequence/primer binding segment pairs LA and PB or PA and LB. Restriction endonuclease digestion of a plurality of vectors containing the DNA segments to be assembled generates a plurality of DNA fragments comprising the elements PA-D-LB, LA-D-LB, and LA-D-PB or D-LB, LA-D-LB, and LA-D. The sequences of annealable linker sequences LA and LB provide complementary termini to the DNA fragments, which are utilized in host cell mediated homologous recombination or together with promer binding segments PA and PB in a polymerase cycling assembly reaction for the ordered assembly of the various DNA segments into one or more assembled polynucleotides. | 2012-09-27 |
20120245057 | WHOLE PROTEOME TILING MICROARRAYS - The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm | 2012-09-27 |
20120245058 | Graphene-Containing Fluids for Oil and Gas Exploration and Production - A base fluid may contain graphene nanoparticles where the base fluid may include an oil-based fluid, a water-based fluid, and combinations thereof. The oil-based fluid may be a brine-in-oil emulsion, or a water-in-oil emulsion, and the water-based fluid may be an oil-in-water emulsion, or an oil-in-brine emulsion; and combinations thereof. The addition of graphene nanoparticles to the base fluid may improve one or more properties of the fluid, which may include the flow assurance properties of the fluid, the fluid loss control properties of the fluid, the rheological properties of the fluid, the stability of the fluid, the lubricity of the fluid, the electrical properties of the fluid, the viscosity of the fluid, the thermal properties of the fluid, and combinations thereof. The fluid may be a drilling fluid, a completion fluid, a production fluid, and/or a servicing fluid. | 2012-09-27 |
20120245059 | USE OF HIGH RATIO AQUEOUS ALKALI SILICATES IN DRILLING FLUIDS - An improved drilling and completion fluid can be used in subterranean drilling for oil and gas. Sodium silicate and potassium silicate-based drilling fluids are commonly used drilling fluids with the notable attributes of exceptional shale stabilization characteristics coupled with exceptional environmental performance Environmental and wellbore stabilization characteristics are improved by using high ratio aqueous silicates wherein ratio is defined as the molar ratio of SiO | 2012-09-27 |
20120245060 | CROSS-LINKERS FOR HYDRAULIC FRACTURING FLUID - A method of forming a wellbore fluid, the method including introducing a hydratable polymer and introducing a crosslinker comprised of at least a silica material, the crosslinker having a dimension of from about 5 nm to about 100 nm. | 2012-09-27 |
20120245061 | ENHANCING DRAG REDUCTION PROPERTIES OF SLICK WATER SYSTEMS - Novel slick water fracturing fluid compositions are disclosed, where the compositions including with slick water fracturing compositions including a partially hydrolyzed polyacrylamide polymer system within invert emulsion and an effective amount of a friction reducer booster system, where the effective amount is sufficient to reduce a drag friction of the composition by an additional amount of at least 5% in the first 30 seconds of evaluation in high salinity and low temperature environments. | 2012-09-27 |
20120245062 | USE OF HIGH RATIO AQUEOUS ALKALI SILICATES FOR PROFILE MODIFICATION, WATER CONTROL AND STABILIZATION - Soluble silicates are commonly used to block and strengthen permeable zones in subterranean formations. These applications include conformance for oil field, grouting for the construction industry and water shut-off for mining. It was discovered that set times and set properties could be improved by using novel, high ratio alkali silicates. Ratio being defined as the mol ratio of SiO | 2012-09-27 |
20120245063 | FUNCTIONALIZED MONOMERS AND POLYMERS - This invention relates to a composition, comprising: an unsaturated functionalized monomer of from about 5 to about 30 carbon atoms, which is: (a) polymerized to form a functionalized polymer; (b) copolymerized with a comonomer to form a functionalized copolymer; or (c) reacted with an enophilic reagent to form a polyfunctionalized monomer. The polyfunctionalized monomer may be polymerized to form a polyfunctionalized polymer which may be further reacted with one or more additional reagents. The invention relates to lubricants, functional fluids, fuels, dispersants, detergents and polymeric resins. | 2012-09-27 |
20120245064 | DRY LUBRICANT FOR CONVEYING CONTAINERS - The passage of a container along a conveyor is lubricated by applying to the container or conveyor a mixture of a water-miscible silicone material and a water-miscible lubricant. The mixture can be applied in relatively low amounts, to provide thin, substantially non-dripping lubricating films. In contrast to dilute aqueous lubricants, the lubricants of the invention provide drier lubrication of the conveyors and containers, a cleaner conveyor line and reduced lubricant usage, thereby reducing waste, cleanup and disposal problems. | 2012-09-27 |
20120245065 | Lubricating Composition Containing an Antiwear Agent - The invention provides a method of lubricating an aluminium-alloy surface of an internal combustion engine comprising supplying to the aluminium-alloy surface a lubricating composition comprising an oil of lubricating viscosity and an alkali or alkaline earth metal phenate detergent. The phenate disclosed herein may further provide antiwear performance on the aluminium-alloy surface. | 2012-09-27 |
20120245066 | Novel Lubricity Enhancing Additives, a Method for Producing the Same and use Thereof - The invention relates to novel lubricity enhancing additives, to a method for producing the same, and to the use thereof. | 2012-09-27 |
20120245067 | SMALL PARTICLE SIZE OIL IN WATER LUBRICANT FLUID - An oil in water lubricant fluid for use in steel cold rolling, comprising an oil in water emulsion having a particle size of 1 μm or less, consisting of an oil phase and water, where the oil phase includes about 5 wt % to about 40 wt % of at least one polymeric surfactant, about 25 wt % to about 95 wt % base oil, about 0.2 wt % to about | 2012-09-27 |
20120245068 | LUBRICANT COMPOSITION HAVING IMPROVED NON-NEWTONIAN VISCOMETRICS - A lubricant composition having improved non-Newtonian viscometrics includes at least 85 weight percent of a base oil and 1 to 15 weight percent of a lubricant additive. The additive itself includes 10 to 80 weight percent of a diluent oil and 30 to 80 weight percent of a random co-polymeric viscosity index improver. The viscosity index improver is the free-radical polymerization product of at least 5 to 15 weight percent methyl methacrylate and 5 to 95 weight percent of a C | 2012-09-27 |
20120245069 | ALDIMINE CLEANING COMPOSITION FOR REACTIVE POLYURETHANE COMPOSITIONS - Methods of using an aldimine of formula (I) as cleaning agent or ingredient of a cleaning agent composition for reactive polyurethane compositions, especially for reactive polyurethane hot melt adhesives. It has been found that such cleaning agents can greatly reduce the quantity of wastes and in particular mixtures of blocked and nonblocked reactive polyurethane compositions can be used without problem for gluing, without the gluing being negatively influenced in its properties, especially its thermal stability. | 2012-09-27 |
20120245070 | Use Of Branched Alkyl(Oligo)Glycosides In Cleaning Agents - Disclosed is the use of alkyl(oligo)glycosides based on selected branched fatty alcohols as hydrotropic agents, preferably for use in cleaning agents, in particular agents for automatic dish washing. | 2012-09-27 |
20120245071 | LAUNDRY STAIN AND SOIL PRETREATMENT DEVICES - A laundry stain and soil pretreatment sheet including a water soluble or water dispersible carrier layer, preferably polyvinyl alcohol, a removable separator layer, and a layer of cleaning agent composition therebetween. The separator layer is removed, the composition layer is adhered to a stain on clothing, and the clothing is laundered. The carrier layer dissolves or disperses during the laundering. The separator layer can be water soluble or water dispersible. Depressions can be provided in the carrier layer to hold the layer of cleaning agent composition. Without the separator layer, a sheet of the carrier layer can be folded over to hold the cleaning agent composition. | 2012-09-27 |
20120245072 | SPRAY-DRIED LAUNDRY DETERGENT PARTICLES - Spray-dried laundry detergent particles including: (a) organic anionic detersive surfactant; (b) water-soluble inorganic salt selected from the group consisting of sodium carbonate and/or sodium sulphate; (c) essentially no zeolite builder; (d) essentially no phosphate builder; (e) essentially no bleach; (f) essentially no clay: (g) essentially no non-ionic detersive surfactant; and (h) other detergent ingredients, wherein from 5 wt % to 25 wt % of the particles are small particles having a particle size of less than 250 micrometers, wherein from 75 wt % to 95 wt % of the particles are large particles having a particle size of 250 micrometers or greater, wherein the ratio of (i) the organic carbon to inorganic carbon weight ratio of the small particles to (ii) the organic carbon to inorganic carbon weight ratio of the large particles is in the range of from 1.00 to 1.25, and wherein the water-soluble inorganic salt has a volume average particle size in the range of from 10 micrometers to 50 micrometers. | 2012-09-27 |
20120245073 | SPRAY-DRIED LAUNDRY DETERGENT PARTICLES - Spray-dried laundry detergent particles wherein from 5 wt % to 25 wt % of the particles are small particles having a particle size of less than 250 micrometers, wherein from 75 wt % to 95 wt % of the particles are large particles having a particle size of 250 micrometers or greater, wherein the ratio of the organic carbon content of the small particles in weight percent to the organic carbon content of the large particles in weight percent is in the range of from 1.00 to 1.20, and wherein the water-soluble inorganic salt has a volume average particle size in the range of from 10 micrometers to 50 micrometers. | 2012-09-27 |
20120245074 | ENHANCED MELTING POINT RINSE AID SOLID COMPOSITIONS WITH SYNERGISTIC PRESERVATIVE - The invention includes a GRAS preservative system including sodium bisulfate and a combination of specific organic acids that act in a synergistic capacity. The preservative further has the benefit of a higher melting point of approximately 110° or higher making it particularly suited for solid wash applications. According to the invention it has surprisingly been found that a combination of sodium bisulfate, sorbic acid, and benzoic acid produced better preservative properties than other organic acid combinations or each acid by itself. | 2012-09-27 |
20120245075 | High Performance Fragrance Formulation - A method of formulating a high performance fragrance formulation by selecting an effective amount of fragrance ingredients selected from the group consisting of aroma chemicals and essential oils defined according to the following algorithm: | 2012-09-27 |
20120245076 | COMPOSITIONS AND METHODS FOR DELIVERING RNAI USING APOE - This invention relates to the use of lipoproteins with oligonucleotides, both single and double stranded, and their use in delivering dsRNA for RNA interference. More specifically, the present invention relates to composititons containing oligonucleotides and alipoprotein E, which enables tissue-specific delivery and reduction of target expression. | 2012-09-27 |
20120245077 | PROKINETICIN 1 RECEPTOR - The present invention relates to methods of monitoring the biological activity of the PK1 receptor. | 2012-09-27 |
20120245078 | MEANS AND METHODS FOR TREATING ISCHEMIC CONDITIONS - The present invention relates to a combination of (a) at least one glucocorticoid; and (ba) at least one proteasome inhibitor and/or (bb) at least one nucleic acid encoding a glucocorticoid receptor, said glucocorticoid receptor being resistant to proteasomal degradation, for use in the treatment or prevention of ischemic disorders of the central nervous system. Furthermore provided is at least one proteasome inhibitor and/or at least one nucleic acid encoding a glucocorticoid receptor, said glucocorticoid receptor being resistant to proteasomal degradation, for use in treating or preventing glucocorticoid resistance in ischemic disorders of the central nervous system. | 2012-09-27 |
20120245079 | Treatment of Diseases Caused by Bacterial Exotoxins - Provided are high affinity T cell receptor variable regions that are useful for treating diseases caused by superantigens including atopic dermatitis, pneumonia and delayed wound healing. The variable regions contain mutants that result in high affinity binding to the superantigen. | 2012-09-27 |
20120245080 | MINERAL SALT-SULFONIC ACID COMPOSITIONS AND METHODS OF USE - The present disclosure generally relates to the medical use of compositions comprising a mineral salt and a sulfonic acid for prevention and/or treatment of one or more mucosal diseases, disorders, or conditions or one or more dermal diseases, disorders, or conditions. | 2012-09-27 |
20120245081 | FAS PEPTIDE MIMETICS AND USES THEREOF - Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide mimetics. Exocyclic anti-Fas peptide mimetics were identified that block Fas receptor-ligand interactions, and modulate Fas biological activity both in vitro and in vivo. The mimetics are useful, e.g., for treating Fas-related pathologies. | 2012-09-27 |
20120245082 | Novel Antimicrobial Activity of Chicken NK-2 Peptide Against Apicomplexan Protozoa - NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like | 2012-09-27 |
20120245083 | Derivatives of CGRP - Acylated CGRP compounds with a linker have prolonged action and are valuable as medicaments. | 2012-09-27 |
20120245084 | FORMULATIONS OF DILUTED AMINO ACID SEGMENTS AND METHODS FOR MAKING SAME - A formulation of a diluted amino acid segment is prepared by mixing an amino acid segment and a diluting agent to form a mixture. The mixture is serially diluted to produce a diluted formulation. The amino acid segment includes a peptide sequence that is the same as a portion of a longer peptide sequence found in a naturally occurring material. A homeopathic remedy can be prepared using the formulation. | 2012-09-27 |
20120245085 | Pharmaceutical Solution of Non Covalently Bound Albumin and Acylated Insulin - If albumin is added to a pharmaceutical formulation containing acylated insulin described in WO 2009/022005 and WO 2009/022013, the acylated insulin can be kept in solution after subcutaneous injection. | 2012-09-27 |
20120245086 | WNT10-Derived Peptide and Use Thereof - The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder using the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics. | 2012-09-27 |
20120245087 | NOVEL TISSUE PROTECTIVE ERYTHROPOIETIN RECEPTOR (NEPOR) AND METHODS OF USE - There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumour allows EPO to impinge on the survival of associated cells thereby enhancing tumour progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumour as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin. Furthermore, by disclosing the molecular compositions of NEPOR species, there are disclosed methods for rationally identifying/designing NEPOR modulating therapeutics. Methods also are provided for treating neurological insults such as stroke (via enhancement of NEPOR activity) and cancer (via down-regulation of cyto-protective signaling from NEPOR). | 2012-09-27 |
20120245088 | COMPOSITIONS COMPRISING IGF1 AGONISTS AND USES THEREOF - Pharmaceutical compositions and methods for improving functional capacity of tissues and organs in both healthy and pathologic disease states for: reducing unwanted cosmetic effects of aging on the skin to reduce wrinkles, to increase collagen and water content, thicken and increase skin volume and to maintain a youthful appearance to age and sun damaged skin, to treat diseases of skin and tissues caused by ischemia of venous congestion and arterial insufficiency, to accelerate healing of tendons, ligaments, joints, cartilage, nerves, bones or neuromuscular injuries or diseases, to improve and restore the functional capacity of specific tissues and organs of the body, and to treat hair loss comprising an effective amount of an insulin-like growth factor selected from the group consisting of IGF-1 (Somatmedin-C) and analogue LR3 IGF1 in admixture with a pharmaceutically-acceptable diluent or carrier. | 2012-09-27 |
20120245089 | USE OF THE SPARC MICROENVIRONMENT SIGNATURE IN THE TREATMENT OF CANCER - The invention provides multiparametric anti-SPARC antibody-based techniques for predicting the response to therapy, including chemotherapy, radiotherapy, surgical therapy and combination therapies | 2012-09-27 |
20120245090 | METHOD FOR SCREENING AN AGENT BEING USEFUL FOR THE TREATMENT OF DRY EYE AND / OR CORNEAL AND CONJUNCTIVAL LESION AND PHARMACEUTICAL COMPOSITION OBTAINED BY THE METHOD - The present invention provides a method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to the report of the International Dry Eye WorkShop (DEWS Report) (2007) and a pharmaceutical composition comprising the agent. The present invention further provides a method for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to DEWS Report (2007) using the agent. | 2012-09-27 |
20120245091 | POLYPEPTIDE OR FUSED PROTEIN THEREOF INHIBITING THE EXTRAVASATION OF WHITE BLOOD CELLS OR THE GROWTH AND/OR METASTASIS OF CANCER CELLS - The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX (or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer. | 2012-09-27 |
20120245092 | POLYPEPTIDES HAVING MODULATORY EFFECTS ON CELLS - The present invention relates to peptides and polypeptides having the sequence SAVTFAVCAL or variants thereof, capable of binding to Calcineurin and/or to NS5A-TP2 and to their use in therapy, as well as to nucleic acid sequences and vectors encoding these peptides and polypeptides, and to cells comprising said polypeptides, nucleic acid sequences or vectors. The invention further relates to the use of the peptides, polypeptides or their derivatives to bring about phenotypic changes in mammalian cells, particularly to up-regulate calcineurin activity. The invention finally relates to a method for intracellular identification of substances which bind to calcineurin and which modulate the physiological effects of calcineurin. | 2012-09-27 |
20120245093 | Neuronal Viability Factor and Use Thereof - This invention relates to methods and compositions for detection and treatment of neurodegenerative diseases. In particular, the invention relates to polypeptides that can protect against neuron degeneration, nucleic acid molecules that encode such polypeptides, and antibodies that recognize said polypeptides. | 2012-09-27 |
20120245094 | COMPOUNDS, COMPOSITIONS AND USE - A peptide comprising a unit of formula (I) and having a molecular weight of less than 2000 wherein each X is independently an organic group, e.g. a C | 2012-09-27 |
20120245095 | BIGLYCAN AND RELATED THERAPEUTICS AND METHODS OF USE - The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders. | 2012-09-27 |
20120245096 | TARGETED DELIVERY OF BOTULINUM TOXIN FOR THE TREATMENT AND PREVENTION OF TRIGEMINAL AUTONOMIC CEPHALGIAS, MIGRAINE AND VASCULAR CONDITIONS - Botulinum toxin, among other presynaptic neurotoxins is used for the treatment and prevention of migraine and other headaches associated with vascular disorders. Presynaptic neurotoxins are delivered focally, targeting the nerve endings of the trigeminal nerve, the occipital nerve and the intranasal terminals of the parasympathetic fibers originating in the Sphenopalatine ganglion. The administration preferably targets the extracranial nerve endings of the trigeminal nerve in the temporal area, the extracranial occipital nerve endings in the occipital area, and the intranasal terminals of the trigeminal nerve and parasympathetic fibers originating in the Sphenopalatine ganglion. The delivery is carried out by way of injection or topically. | 2012-09-27 |
20120245097 | USE OF PEDF-DERIVED POLYPEPTIDES FOR PROMOTING STEM CELLS PROLIFERATION AND WOUND HEALING - Disclosed herein is a synthetic peptide, which has an amino acid sequence that has 20-39 amino acid residues. The synthetic peptide has at least 80% amino acid sequence identity to SEQ ID NO: 1, and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 11-30 of SEQ ID NO: 1. Also disclosed herein are compositions containing the synthetic peptide and applications thereof. According to various embodiments of the present disclosure, the synthetic peptide is useful in promoting stem cells proliferation or wound healing. | 2012-09-27 |
20120245098 | Topical Palmitoyl Glutathione Formulations - A topical composition for application to aging skin, comprising an effective amount of S-acyl glutathione derivative of formula (I) | 2012-09-27 |
20120245099 | APOPTOSIS INDUCER - The present invention provides an apoptosis-inducing agent capable of inducing apoptosis in various cells including tumor cells and other cells in a simple manner, etc. The apoptosis-inducing agent of the present invention comprises a peptide shown in (a) or (b) below, a derivative thereof, or a salt of the peptide or the derivative: (a) a peptide which comprises an amino acid sequence represented by the formula: C—X-D-X—X—X—X—Y—X—C—X—C (SEQ ID NO: 1)(I); or (b) a peptide which comprises an amino acid sequence with deletion, substitution or addition of one or several amino acids in the amino acid sequence represented by formula (I) and which has apoptosis-inducing activity. | 2012-09-27 |
20120245100 | PLASMID FOR EXPRESSION OF TRANSGENES IN PLANTS - A plasmid for use in transferring a chicken anemia virus apoptin coding sequence into a plant includes a binary vector suitable for transferring DNA from | 2012-09-27 |
20120245101 | SYNTHETIC APOLIPOPROTEIN E MIMICKING POLYPEPTIDES AND METHODS OF USE - The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical peptide, or a modified version thereof. Such peptides enhance low density lipoprotein (LDL) and very low density lipoprotein (VLDL) binding to and degradation by fibroblast or HepG2 cells. Also provided are possible applications of the synthetic peptides in lowering human plasma LDL/VLDL cholesterol levels, thus inhibiting atherosclerosis. The present invention also relates to synthetic peptides that can improve HDL function and/or exert anti-inflammatory properties. | 2012-09-27 |
20120245102 | PARTIAL PEPTIDE OF LACRITIN - The invention provides a polypeptide containing an amino acid sequence, which is a particular partial sequence of lacritin and is characterized by gyro-modification of N-terminal glutamine. The polypeptide promotes adhesion between a cell and extracellular matrix and is stable in aqueous solution. | 2012-09-27 |
20120245103 | Silk Proteins - The present invention provides silk proteins, as well as nucleic acids encoding these proteins. The present invention also provides recombinant cells and/or organisms which synthesize silk proteins. Silk proteins of the invention can be used for a variety of purposes such as in the manufacture of personal care products, plastics, textiles, and biomedical products. | 2012-09-27 |
20120245104 | NOVEL RETRO-INVERSO LEPTIN PEPTIDE ANTAGONISTS - Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence. Further disclosed are truncations, modifications and retro-inversions of the peptides of the present invention. | 2012-09-27 |
20120245105 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR CONTRIBUTING TO THE TREATMENT OF SOLID TUMORS - Methods, compositions and articles of manufacture for contributing to the treatment of a solid cancerous tumor are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ET | 2012-09-27 |
20120245106 | MODIFIED LYSINE-MIMETIC COMPOUNDS - Lysine mimetic compounds having useful pharmacological activity such as antiarrhythmic activity and desirable bioavailability properties are disclosed. | 2012-09-27 |
20120245107 | METHODS OF REDUCING THE PROLIFERATION AND VIABLILITY OF MICROBIAL AGENTS - The invention relates to formulations of an antimicrobial agent, a lipid, and optionally a surfactant, and uses thereof for reducing the proliferation and viability of microbial agents. | 2012-09-27 |
20120245108 | METHOD OF MODULATING COMPLEMENT FACTOR B (CFB) EXPRESSION IN CELLS - The present invention relates to a method of modulating complement factor B (CFB) expression in cells, comprising administering an effective amount of tannic acid to the cells. This method can be applied in treating or prophylaxis of the disease, disorder or medical condition associated to complement factor B (CFB) expression. | 2012-09-27 |
20120245109 | ANTITHROMBOTIC DUAL INHIBITORS COMPRISING A BIOTIN RESIDUE - The present invention relates compounds of the formula (I) | 2012-09-27 |