39th week of 2008 patent applcation highlights part 51 |
Patent application number | Title | Published |
20080234479 | Novel Process For Preparation of a Pharmaceutically Pure Polymorphic Form I of Olanzapine - The invention is directed to a novel method for making crystalline Form I of Olanzapine, wherein crude olanzapine is dissolved in a water-miscible solvent in which it is freely soluble, from which substantially pure polymorphic Form I of Olanzapine is recovered by precipitation. | 2008-09-25 |
20080234480 | Triphendioxazine Pigments - The invention relates to novel triphendioxazine pigments of formula (I) | 2008-09-25 |
20080234481 | Novel triazolo pyrimidine compounds - The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals. | 2008-09-25 |
20080234482 | 5,6-Dimethylthieno[2,3-Di] Pyrimidine Derivatives, the Preparation Method Thereof and the Pharmaceutical Composition Comprising the Same for Anti-Virus - Disclosed herein are 5,β-dimethylthieno[2,3-d]pyrimidine derivatives useful as antiviral agents. More particularly, disclosed are 5,β-dimethylthieno[2,3-djpyrimidine derivatives represented by Formula 1, having an excellent inhibitory effect on the proliferation of hepatitis C virus (HCV), pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the prevention and treatment of hepatitis C virus (HCV), containing, as active ingredients, these compounds. The 5,6-dimethylthieno[2,3-d]pyrimidine derivatives represented by Formula 1 have an excellent effect of inhibiting the proliferation of hepatitis C virus and also have low toxicity. Thus, these compounds are available as agents for the prevention and treatment of hepatitis C. | 2008-09-25 |
20080234483 | Fasudil-Containing Preparation and Method of Improving Stability Thereof - Fasudil-containing preparations that despite the us of a container excelling in the visibility of contents without particularly blocking of light, exhibit high stability against light; and a method of improving the stability of the preparations against light of storing the same. By regulating the pH value of aqueous solution of fasudil charged in a colorless transparent container to ≦5.5, there can be provided fasudil-containing preparations excelling in stability against light; and can be provided a method of improving the stability of the aqueous solution of fasudil against light, or storing the same. | 2008-09-25 |
20080234484 | Method for making tris (8-hydroxyquinoline) nano-crystal - A method for making a tris-(8-hydroxyquinoline) aluminum (Alq3) nano-crystals includes the steps of: (a) dissolving Alq3 powders into a solvent to form a solution A; (b) dissolving a surfactant in water to achieve a solution B; (c) uniformly mixing the solution A and the solution B to form a latex C; and (d) removing the solvent from the latex C, and subsequently, subjecting the remaining solute to centrifugal separation to form Alq3 nano-crystals. | 2008-09-25 |
20080234485 | 1-Benzyl-4-[ (5,6-Dimethoxy-1-Indanon) -2-Yl] Methylpiperidine Hydrobromide or Crystals Thereof - 1-Benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrobromide or a solvate thereof. | 2008-09-25 |
20080234486 | Novel Processes for the Production of Amorphous Rabeprazole Sodium - The invention is directed to overcome the problems associated with the formation of rabeprazole sodium, i.e. formation of (2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfonyl)-1H-benzimidazole side product which is achieved by a process for the preparation of amorphous rabeprazole salt, e.g. sodium, comprising the steps of:
| 2008-09-25 |
20080234487 | SUBSTITUTED SULFOXIDE COMPOUNDS, METHODS FOR PREPARING THE SAME AND USE THEREOF - Disclosed are an optically pure compound having formula I, its pharmaceutically acceptable salt and its pharmaceutically acceptable solvate, and a use thereof in manufacturing medicaments and pharmaceutical compositions. A process for preparing the compound defined therein is also provided. | 2008-09-25 |
20080234488 | Method of Deuteration Using Mixed Catalyst - The subject of the present invention is to provide a method for deuteration, which can obtain a compound having an aromatic ring and/or a heterocyclic ring at an improved deuteration ratio. The present invention relates to a method for deuteration of a compound having an aromatic ring and/or a heterocyclic ring, comprising reacting the compound having an aromatic ring and/or a heterocyclic ring with a heavy hydrogen source in the presence of an activated mixed catalyst of not less than two kinds of catalysts selected from among a palladium catalyst, a platinum catalyst, a rhodium catalyst, an iridium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. | 2008-09-25 |
20080234489 | Method of synthesis of the sodium salt of N-acetyl-L-cysteinylcobalamin - The invention provides a method for preparing the sodium salt of the novel thiol derivative of vitamin B | 2008-09-25 |
20080234490 | Metal Salts of 2' - (1H-Tetrazol-5Yl) -1. 1'-Biphenyl-4-Carboxaldehyde - The invention relates to a method or process for the manufacture of blood pressure lowering agents, such as valsartan, novel intermediates as well as process steps in said synthesis. The method or process leads via the novel intermediate salts of the formula IA, | 2008-09-25 |
20080234491 | PROCESS FOR PREPARATION OF CELECOXIB - There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purification of celecoxib using aromatic hydrocarbon solvents. | 2008-09-25 |
20080234492 | Process for the Preparation of Carvedilol - A process for the preparation of carvedilol of formula (I) (I) either in enantiomeric substantially pure form, or as an enantiomeric mixture, optionally as a pharmaceutically acceptable salt thereof, which process comprises reacting 2,3-eopxypropoxy carbazole of formula (II) (II) or the R or S enantiomer thereof, with N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) (V) to yield benzyl carvedilol of formula (VI) (VI) which is debenzylated by catalytic hydrogenation to yield carvedilol of formula (I), either in enantiomeric substantially pure form, or as an enantiomeric mixture, and if desired reacting the thus formed carvedilol of formula (I) with an inorganic or organic acid to yield a pharmaceutically acceptable salt thereof, and/or, if desired, separating the enantiomers. The above process is characterised in that reaction of said 2,3-epoxypropoxy carbazole of formula (II) with said N-[2-(2-methoxy-phenoxy)ethyl]-benzylamine of formula (V) is carried out in water as the reaction medium. The present invention further provides carvedilol of formula (I) prepared by a process as described above, and pharmaceutical compositions containing the same and therapeutic uses thereof. | 2008-09-25 |
20080234493 | Process for the Preparation of 2-[N-[{S)-1-Ethoxycarbonyl-3-Phenylpropyl]-(S)-Alanyl]-(1S,3S,5S)-2-Azabicyclo[3.3.0]Oct- an-3-Carboxylic Acid - A process for preparation of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-(S)-alanyl]-(1S,3S,5S)-2- azabicyclo [3.3.0] octane-3-carboxylic acid, ie. Ramipril, involves condensation of an activated derivative of 2-[N-](S)-1-ethoxycarbonyl-3-phenylpropyl]-(S)-alanine with racemic (1R*,3R*,5R*)-2-azabicyclo[3.3.0]octane-3-carboxylic acid, and then the desired diastereoisomer (1a) is separated from the obtained diastereoisomeric mixture of 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl](S)-alanyl]-(1S,3S,5S)-2-azabicyclo[3.3.0]octane-3-carboxylic acid (1a) and 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl -alanyl]-(1R,3R,5R)-2-azabicyclo[3.3.0]octane-3-carboxylic acid (1b) by treating it with a solvent that selectively dissolves the undesired diastereoisomer (1b) while the diastereoisomer (1a) remains undissolved. | 2008-09-25 |
20080234494 | Indolylmaleimide Derivatives - A compound of formula I | 2008-09-25 |
20080234495 | Process for the Preparation of Almotriptan - The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl) 1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic acid yields hydroxy benzoic acid addition salt of Almotriptan iii) Converting Almotriptan hydroxy benzoic acid addition salt to Almotriptan and iv) Salification of Almotriptan to its pharmaceutically acceptable salts | 2008-09-25 |
20080234496 | PROCESS FOR PURIFYING PPPBP - A method for decoloring 2-phenyl-3,3-bis(4-hydroxyphenyl)phthalimidine (“p,p-PPPBP”) is disclosed. The method comprises contacting a liquid solution containing p,p-PPPBP and the common impurities o,p-PPPBP and aminophenone with activated carbon fibers. The activated carbon fibers adsorb the impurities, resulting in a purified solution of p,p-PPPBP. The activated carbon fibers can then be regenerated, such as with a methanol solution having a highly basic pH. | 2008-09-25 |
20080234497 | NOVEL PEGYLATED AMINO ACID DERIVATIVES AND THE PROCESS TO SYNTHESIZE THE SAME - The present invention is a series of novel pegylated amino acid derivatives containing branched polyethylene glycols, which are either the same or different molecular weights. Additionally, the N-pegylated lysine derivatives are enantiomerically pure. Also disclosed are oligopeptides such as Lysine-Lysine in which the free amino groups are protected as pegylated carbamates. 9-BBN complexes of lysine in which the epsilon nitrogen is functionalized as a pegylated carbamate and Bis pegylated derivatives of multifunctional heteroatom-containing amino acids such as cysteine, serine and glutamic acid are also disclosed. | 2008-09-25 |
20080234498 | Pyrovalerone Analogues and Therapeutic Uses Thereof - New compounds that bind to monoamine transporters are described. The compounds of the present invention can be racemic or pure R— or S-enantiomers. Certain preferred compounds of the present invention have a high selectively dopamine transporter versus the serotonin transporter. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | 2008-09-25 |
20080234499 | Synthesising Method and Benzoxathiepine Intermediates - The invention relates to preparing derivatives of formula (1), wherein, in particular R | 2008-09-25 |
20080234500 | Purification Process For Lactide - The present case relates to a process for the purification of lactide from a crude lactide vapour product stream which process comprises a rectification/condensation step leading to a lactide-enriched condensate. | 2008-09-25 |
20080234501 | Method for Producing 2,5-Dimethylphenyl Acetic Acid - The invention relates to a method for preparing 2,5-dimethylphenylacetic acid by converting p-xylene with chloroacetyl chloride into 2-chloro-1-(2,5-dimethylphenyl)ethanone, which is reacted with the compound of the formula (II) to give the compound of the formula (III), which is then rearranged to give a mixture of the compounds (IV) and (V), which is then hydrolyzed to 2,5-dimethylphenylacetic acid. | 2008-09-25 |
20080234502 | Production method of optically active epoxy compound, complex used for the method and production method of the complex - [Problem] To provide a production method of optically active epoxy compound, and a complex used for the production method and a production method of the complex.
| 2008-09-25 |
20080234503 | Purification of Mupirocin - A method for purification of the antibiotic mupirocin (pseudomonic acid A) which comprises: a) Causing or allowing precipitation of mupirocin from an aqueous solution thereof; b) Recovering the precipitate; c) Dissolving the recovered precipitate in an organic solvent. | 2008-09-25 |
20080234504 | Processes for preparation of 9-haloacetamidominocyclines - The present invention provides substantially pure intermediates, 9-haloacetomidominocyclines, and process of preparing them that are useful for the preparation of glycylcyclines, specifically Tigecycline. | 2008-09-25 |
20080234505 | Exemestane and Its Intermediates and Methods of Making the Same - A method is provided for preparing an aromatase inhibitor of formula (I) wherein each of R | 2008-09-25 |
20080234506 | PROCESS FOR THE PREPARATION OF FLUOROTETRAENE - There is provided a process for preparing 21-acetyloxy-6-alpha-fluoro-pregna-1,4,9(11),16-tetraene-3,20-dione compound of Formula I, which comprises reacting 21-acetyloxy-pregna-1,3,5,9(11),16-pentaene-3-oxo acetate with a fluorinating agent. | 2008-09-25 |
20080234507 | Encapsulated liposomes and methods of making same - Encapsulated liposomes containing active components are disclosed. Methods of making the encapsulated liposomes are also disclosed. Applications in which the encapsulated liposomes may be used are additionally disclosed. | 2008-09-25 |
20080234508 | Process for the Preparation of N(5)-Ethylglutamine - Disclosed relates to a process for preparing N(5)-ethylglutamines economically without a specific purification process via a simplified and safe process, in which glutamic acid derivatives, represented by formula 1, protected by phthaloyl groups react with ethylamine to cause an amidation and a deprotection reaction in turn under the same reaction condition, thus preparing N(5)-ethylglutamines. | 2008-09-25 |
20080234509 | Stereoregular polymer and monomer thereof and process for production of both - An ester derivant having a crystal structure in which the molecules in two adjacent molecule planes are antiparallel is created from a carboxylic acid having carbon-carbon double bond and a compound having a functional group that can react to a carboxyl group of the carboxylic acid. The crystal of the ester derivant is then subjected to light irradiation or heating. | 2008-09-25 |
20080234510 | Method of Obtaining Polyoxygenated Organic Compounds - The invention relates to a method of obtaining polyoxygenated organic compounds. The inventive method is characterized in that it comprises the oxidation reaction of a diether, preferably an acetal, with an oxygen source, in the presence of: one or more radical initiating agents, one or more additives that generate a basic reaction medium, and one or more catalysts. | 2008-09-25 |
20080234511 | Process for Preparing Vinyl Acetate with Utilization of the Heat Reaction - Vinyl acetate is prepared by | 2008-09-25 |
20080234512 | Integrated process for producing carbonylation acetic acid, acetic anhydride, or coproduction of each from a methyl acetate by-product stream - The present invention is directed to using methyl acetate from a vinyl acetate-based or a vinyl-or ethylene-alcohol based polymer or copolymer process directly for use in a methanol carbonylation production process to produce acetic acid, acetic anhydride, or a coproduction of each. | 2008-09-25 |
20080234513 | Oxide Catalyst for Oxidation or Ammoxidation - Disclosed is an oxide catalyst for use in catalytic oxidation or ammoxidation of propane or isobutane in the gaseous phase, which comprises a composition represented by the Mo | 2008-09-25 |
20080234514 | Methods for the preparation, formulation and use of lithium valproate - The present invention relates to methods for preparing lithium valproate and administering this compound to a subject in need of treatment with lithium and/or valproate. Pharmaceutical compositions are also provided that are useful therapies for the treatment of neurological, immunological, and viral-mediated disorders in warm-blooded mammals. | 2008-09-25 |
20080234515 | Process for making a (meth)acrylamide monomer - A method for making a (meth)acrylamide monomer, comprises reacting a (meth)acrylate ester with an amino-functional compound in an organic solvent in the presence of a transesterification catalyst. | 2008-09-25 |
20080234516 | Processes for preparing solid states of O-desmethylvenlafaxine succinate - Provided are processes for the preparation of amorphous O-desmethylvenlafaxine and for the preparation of crystalline forms I, II, III, and IV of O-desmethylvenlafaxine. | 2008-09-25 |
20080234517 | ALKYLATION OF N'-PHENYL-N-ALKYLPHENYLENEDIAMINES IN IONIC LIQUID AND N'-PHENYL-N-ALKYL(ALKYLPHENYLENE) DIAMINES PRODUCED THEREBY - A process for alkylation of a N′-phenyl-N-alkyl-p-phenylenediamine of specified formula in an ionic liquid unexpectedly produces a N′-phenyl-N-alkyl(alkylphenylene)diamine of a second specified formula. The use of an inorganic liquid permits convenient separation of the alkylated reaction product from the reaction mixture. | 2008-09-25 |
20080234518 | Process for producing aromatic amines - Aromatic amines are produced by adiabatic hydrogenation of nitroaromatic compounds in the gas phase on one or more fixed catalysts. The nitroaromatic reactant is passed over the catalyst under pressure and at elevated temperature with hydrogen, water, optionally nitrogen and substantially in the absence of the aromatic amine produced from the nitroaromatic. | 2008-09-25 |
20080234519 | Process For the Manufacture of Aminopolyalkylenephosphonic Acid Compounds - A beneficial method for the manufacture of amino polyalkylene phosphonic acids, under substantial absence of hydrohalogenic acid, is disclosed. The method, in essence, is based on reacting narrowly defined ratios of phosphorous acid, an amino, a formaldehyde in presence of specific ranges of an acid catalyst having a pKa equal or inferior to 3.1. The inventive method is capable of yielding economically and quality operational/capacity advantages, in particular significantly reduced one-step cycle duration under exclusion, of corrosion disadvantages and also is environmentally friendly without requiring, in that respect, anything more than nominal capital expenditures. | 2008-09-25 |
20080234520 | PROCESS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES - Novel processes for preparing arylsulfur pentafluorides are disclosed. Processes include reacting at least one aryl sulfur compound with a halogen and a fluoro salt to form an arylsulfur halotetrafluoride. The arylsulfur halotetrafluoride is reacted with a fluoride source to form a target arylsulfur pentafluoride. | 2008-09-25 |
20080234521 | CRYSTAL FORMS OF ASTAXANTHIN - Mixtures of specific crystal forms of astaxanthin and the individual crystal forms designated crystal Form I and II and disclosed together with methods for preparing said crystal Forms. Methods for preparing nutritional dosage forms including the disclosed astaxanthin crystal forms for the life science industry are also disclosed. | 2008-09-25 |
20080234522 | Method for vapor phase catalytic oxidation - An object of the present invention is to provide a method for vapor phase catalytic oxidation which is almost free of variations in reaction states in respective reaction tubes of the fixed bed multi-tube heat-exchanger type reactor. | 2008-09-25 |
20080234523 | Process for making isooctenes from aqueous 2-butanol - The present invention relates to a catalytic process for making isooctenes using a reactant comprising 2-butanol and water. The isooctenes so produced are useful for the production of fuel additives. | 2008-09-25 |
20080234524 | Process for the liquid phase selective hydroxylation of benzene - The present invention provides an improved process for the liquid phase selective hydroxylation of benzene. The process provides a direct single step selective liquid phase hydroxylation of benzene to phenol using environment friendly green oxidant, hydrogen peroxide, and vanadyl pyrophosphate as the catalyst under mild reaction conditions. The process provides benzene conversion of 30-70% and selectivity for phenol of up to 100%. | 2008-09-25 |
20080234525 | Sulfonate Catalyst and Method of Producing Alcohol Compound Using the Same - A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol. | 2008-09-25 |
20080234526 | Trityl chloride recovery - Methods of recovering a triarylmethyl halide from a sucrose derivatization process include the steps of
| 2008-09-25 |
20080234527 | Method for Producing Hydrogen and System Therefor - The present invention provides a hydrogen production method capable of producing hydrogen with good efficiency while solving problems such as separation, lower-temperature reaction and heat supply in production of hydrogen by dehydrogenation reaction of raw material oil. Within a reaction tube of a double-tube structure comprising an inner tube composed of a hydrogen separating membrane, a metallic outer tube having a plurality of internal fins, and a metal oxide layer and further a catalyst supported on the fins, hydrocarbon having cyclohexane ring is dehydrogenated to produce hydrogen and aromatic hydrocarbon, and selective membrane separating operation of hydrogen is performed within the reaction system while conducting the dehydrogenation to remove mainly the hydrogen on a permeating side and obtain mainly the aromatic hydrocarbon on a non-permeating side. The other method comprises absorbing at least part of the resulting hydrogen flow to a hydrogen absorbing (storing) alloy to make the pressure on the hydrogen permeating side of the hydrogen separating membrane lower than that on the non-permeating side. | 2008-09-25 |
20080234528 | Catalytic isobutane alkylation - A novel catalytic reactor is provided for controlling the contact of a limiting reactant with a catalyst surface. A first flow vessel defines an interior surface and an exterior surface, and the interior surface has a catalyst deposited on at least a portion thereof. A second flow vessel is positioned within the first flow vessel and the second flow vessel defines a porous surface designed to deliver a fluid uniformly to at least a portion of the interior surface of the first flow vessel. | 2008-09-25 |
20080234529 | Treatment of Elemental Mercury - The invention concerns a method for the stabilisation and disposal of elemental mercury, the method comprising treating the elemental mercury with a cementitious particulate filler material which additionally comprises an immobilisation treatment. In a preferred embodiment, the immobilisation treatment comprises an amalgamation treatment prior to the treatment with a cementitious particulate filler material. Preferably, the amalgamation is carried out using copper powder and dilute nitric acid and the cementitious particulate filler material comprises a mixture of Ordinary Portland Cement and Blast Furnace Slag. The method of the invention is carried out conveniently and rapidly, and the end product, after allowing to cure, is non-toxic, insoluble in water, easily handled, and immediately suitable for disposal. The method is particularly applicable to the safe disposal of elemental mercury which is contaminated with radioactive materials. | 2008-09-25 |
20080234530 | Atmospheric Pressure Plasma Treatment of Gaseous Effluents - The invention relates to a method for the conversion of a gas or gas mixture and, in particular, a fluorinated gaseous effluent. According to the invention, at least one bond between two atoms of at least one molecule of the gas or gas mixture is broken under the influence of an electric and/or magnetic field to which the gas or gas mixture is subjected. The gas or gas mixture stream is injected through the electric and/or magnetic field in a non-rectilinear manner in order to increase the distance travelled by the gas molecules through the field and, in this way, increase the effectiveness of the conversion of the gas or gas mixture molecules. | 2008-09-25 |
20080234531 | BI-POLAR TREATMENT FACILITY FOR TREATING TARGET CELLS WITH BOTH POSITIVE AND NEGATIVE IONS - A system for treating target cells with both positive and negative ions comprises a bi-polar beam delivery system configured to create and deliver both positive ion beams and negative ion beams. The bi-polar beam delivery system comprises a bi-polar accelerator configured to accelerate positive and negative ions in the same direction making such a bi-polar bema delivery system practical. | 2008-09-25 |
20080234532 | FIDUCIAL MARKER - A fiducial marker which is visible to a wide range of imaging techniques, comprises a radiopaque material, such as barium sulphate or a metal wire, encapsulated in a biocompatible polymeric material, for example a polyaryletherketone such as polyetheretherketone. | 2008-09-25 |
20080234533 | System for evaluating an environment - An environmental evaluation device and system enables determination of the ambit and orientation of an environment and the favorability of the environment for an individual according to principles of feng shui. | 2008-09-25 |
20080234534 | Magnetic Therapeutic Appliance and Method for Operating Same - The invention relates to a therapeutic appliance for treating a patient with an electric field or a magnetic field. In known therapeutic appliances, resistance losses in the coils needed for the magnetic field lead to undesired warming of the therapeutic appliance. According to the invention, the energy of the coil ( | 2008-09-25 |
20080234535 | Device and method for thrombosis and pulmonary embolism - This disclosure describes novel therapeutic devices and methods for thrombosis or pulmonary embolism at physiological temperature that are based upon electromagnetic pulsed energy sources of Near Infrared (NIR) and Far Infrared (FIR) that pulsed radiations are exposed to the human body for prevention and treatment. The pulsed sources may work in the devices in coincidental, uncoincidental or sequential modes with variable pulse durations, variable pulse repetitions or variable pulse intensities, and the modes or pulse properties are selected accordingly to thrombosis or pulmonary embolism conditions. | 2008-09-25 |
20080234537 | Extracardiac Blood Flow Amplification Device - Apparatus ( | 2008-09-25 |
20080234538 | Device and Method for Thermotherapy - A thermotherapy device, in particular for babies, has a lying surface limited by longitudinal sides, a head side and a foot side. The thermotherapy device ensures a simple and safe access of a new-born without producing a detrimental psychological effect on parents. For this purpose, an upwardly oriented feeding device for supplying a hot and humid air is advantageously embodied in three parts, namely, a lateral feed pipe in each longitudinal part and/or a feed pipe in each foot side, a suction device for sucking supplied air is arranged above the lying surface, the suction device is arranged above the head side, in particular above the head area of the lying surface in such a way that the supplied air is sucked only above said head side and/or the head area. | 2008-09-25 |
20080234539 | SOFT TISSUE PLACEMENT OF IMPLANTABLE MICROPHONE - Provided herein are systems and methods where an implantable microphone of an implantable hearing system is positioned at a location spaced from the surface of the patient's skull. More specifically, the microphone is mounted to soft tissue of the patient to at least partially isolate the microphone from skull-borne vibrations. Accordingly, by utilizing a soft tissue mount, the microphone may be made more sensitive to ambient sounds with reduced concern to amplification of non-ambient vibrations caused by skull-borne vibrations including, for example, transducer feedback, talking and/or chewing. The system will further include an auditory stimulation device that is located proximate to the skull of the patient and which is operative to stimulate an auditory component of the patient in accordance with an output signal generated by the microphone. A subcutaneously routed signal wire may extend between the implanted microphone and the auditory stimulation device. | 2008-09-25 |
20080234540 | Osteochondral Implant Procedure - A surgical procedure according to which a moldable material is positioned over a defect and over an area of the anatomy surrounding the defect so that the moldable material takes the shape of the area. After the moldable material forms a mold, a graft is placed on the mold; and cut to conform to a dimension of the defect. | 2008-09-25 |
20080234541 | SYSTEMS AND METHODS OF PROMOTING ENDOTHELIALIZATION OF A HYBRID CAROTID BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in die specimen holder. Embodiments of methods can promote endothelialization of a hybrid carotid bypass vascular graft by placing the hybrid carotid bypass vascular graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid vascular graft. | 2008-09-25 |
20080234542 | SYSTEMS AND METHODS OF COATING A HYBRID LOWER LIMB ARTERY BYPASS VASCULAR GRAFT IN A MAMMAL - Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid graft with a confluent monolayer of endothelial cells by immobilizing stem cells on a hybrid lower limb artery bypass vascular graft, placing the hybrid graft in a system embodiment according to the invention under conditions effective to promote the stem cells to form a confluent monolayer on the surface of the hybrid vascular graft and in an environment to promote the stem cells to differentiate into endothelial cells. | 2008-09-25 |
20080234543 | SURGICAL DEVICES AND METHOD FOR VAGINAL PROLAPSE REPAIR - In accordance with at least one exemplary embodiment, a vaginal prolapse repair procedure can use a perirectal pass in placing an anterior graph arm. For example, the superficial straps of an anterior graft can be place via the transobturator path. The deep straps can be placed via perirectal passes. An exemplary anterior graft can include deep straps that extend from the body of the anterior graft at an angle between about 25 and 60 degrees. Also, an exemplary anterior graft can have a biologic or an absorbable, synthetic strip for providing a window in the implanted graft. An exemplary trocar sheath can be extended and can have a side entry port for cooperating with a trocar. Also, exemplary graspers or retrieval portions of exemplary sheaths can have a reversible locking/mating mechanism for coupling graft arms. Moreover, an exemplary trocar can be provided. | 2008-09-25 |
20080234544 | Displaying images interior and exterior to a body lumen of a patient - A medical system includes a display monitor, a catheter, non-light-obtained image data of a patient, and a computer. The catheter has a distal end insertable into a body lumen of the patient. The catheter is adapted to provide light-obtained image data. The computer is adapted to create a first image representation of the patient interior to the body lumen using at least the light-obtained image data indexed to a reference coordinate system, to create a second image representation of the patient exterior to the lumen using at least the non-light-obtained image data indexed to the reference coordinate system, and to display on the monitor a registered overlay image of the first and second image representations. A storage medium contains a program readable by a computer which instructs the computer to perform the previously described steps. A method for visualizing a position of a catheter within a patient performs the above-described steps. | 2008-09-25 |
20080234545 | Instrument for Fine-Mechanical or Surgical Applications - The invention relates to an instrument for high-precision or surgical applications of a minimally invasive nature, comprising a distally positioned directable head, a shaft upon which the head is positioned, and a proximally positioned handgrip for operating the head, wherein a ring of cables comprising longitudinally extending cables connects to the head, wherein each cable of the ring of cables is disposed such that at least a part of both sides is in direct contact with another cable of the ring of cables, and wherein the cables are fixedly secured in the radial direction. | 2008-09-25 |
20080234546 | IN VIVO OBSERVATION DEVICE - This in vivo device is provided with a capsular casing and a foreign object removing device. The capsular casing is taken into a living body. The foreign object removing device removes a foreign object between a surface of a body tissue and the casing. | 2008-09-25 |
20080234547 | Deflectable Autoclavable Endoscope - An endoscope has a shaft housing a lighting and an image transmission system and said endoscope being designed to be autoclavable. The shaft has a distal end portion which is made deflectable. An outer part is provided which is attached to said shaft. The outer part has a deflector mechanism for deflecting said deflectable distal end portion of said shaft and said outer part can be attached to said shaft by being releasably mounted laterally onto said shaft. | 2008-09-25 |
20080234548 | Narrow band in-vivo imaging device - An in-vivo imaging device for capturing one or more narrow band images of the gastrointestinal tract, or other body lumens or cavities of a patient, using one or more narrow band illumination sources and an imager having an array of light sensitive elements. | 2008-09-25 |
20080234549 | Laryngoscope blade - A laryngoscope blade comprising a blade portion, a base portion and an optic light pipe, the blade portion including a proximal end and a distal end provided with an optic window, the base portion including two base halves mounted to each other and to the proximal end of the blade portion, one of the base halves providing a resilient cantilever latch pin and the other of the base halves providing a rigid hook, the light pipe including a proximal end mounted between the two base halves and a distal end extending through the optic window. | 2008-09-25 |
20080234550 | Minimally Traumatic Portal - A less invasive access port for use in minimally invasive surgery allows for manipulation of the viewing angle into the working site in a transverse plane. According to one exemplary embodiment, the less invasive access port is designed to minimize the need for muscle retraction. Additionally, the less invasive access portal provides sufficient light, irrigation, suction and space for sundry medical instruments. According to one exemplary embodiment, a less invasive access port device includes a retractor assembly having four retractor blades secured in various positions by pins placed within slots on the retractor blades. A cannula includes integrated interfaces for light, irrigation and suction. A housing forms a collar around a top of the cannula and houses the light, irrigation and suction mechanisms. Instruments and implants may be passed through the cannula and into the working space created by the retractor assembly. Visualization of the working site can be attained under direct vision. | 2008-09-25 |
20080234551 | Gasless Laparoscopic Retractor Structure - Abdominal annular pack structure for gasless laparotory operation comprises an annular ring, a plurality of hooks and adjusting devices, a fixation ring and a stationary pole with an adjusting rod. The stationary pole is erected on one side of the operation table to settle the adjusting rod thereon in position. The adjusting rod is provided with a clamp at its one end for clutching the fixation ring in position. The fixation ring is disposed to encircle the annular ring surrounding the wound open on the patient belly part. Each adjusting device is connected respectively to its corresponding hook with a pulling string so as to apply a variable tensile force to the annular ring thereby able to adjust the size and shape of the wound. With this structure, the surgical operation may be carried out securely and perfectly without filling the gas (CO | 2008-09-25 |
20080234552 | BMI Ruler - A device for measuring the Body Mass Index (BMI) of an adult, providing a measure of weight for height. The device allows for an easy and quick determination of BMI or the adult weight status. The device consists of a hand held slide ruler instrument on which a combination of an adult's weight and height immediately indicates the corresponding BMI. Using this device, an adult over 18 years old can determine how much weight he/she would need to lose or gain in order to achieve normal weight, as specified by the current US government guidelines. | 2008-09-25 |
20080234553 | NON-INVASIVE HUMAN-HEALTH-MEASUREMENT SYSTEM AND METHOD - Methods and hand-held devices non-invasively measure a health parameter in an individual or a plurality of individuals. Plural hand-held devices may be provided to plural individuals. Each device may compute a score based on the assayed health parameter in the individual. A server on a computer network may receive the scores and determine a pattern based on the scores. The hand-held devices may be further configured to receive additional data from the individuals regarding activities that may affect the individuals' scores. The server may receive the additional data from the devices and determine additional patterns. | 2008-09-25 |
20080234554 | Computer-Aided System for Limb Lengthening - An apparatus for lengthening of extremities includes at least two supporting rings, a plurality of spikes mounted in each of the at least two supporting rings by spike-fixating elements, the at least two supporting rings connected with one another by threaded rods, which are displaced into rectilinear movement by automated drives connected with a portable block for power supply and control. Each automated drive includes a screw pair composed of a threaded rod and a threaded insert mounted via two bearings that are spaced from one another, and movable through a reducer with a stepper motor. The portable block is provided with elements for controlling a speed and a direction of movement of each of the automated drives, and a unit is provided for calculation and indication of displacement supplied by each of the automated drives. | 2008-09-25 |
20080234555 | PATIENT CARE SYSTEM - A patient care system includes a support, with a lower portion and an upper portion, and a controller. The upper portion is removably mounted to the lower portion wherein the upper portion may be removed from the lower portion. The lower portion of the support is adapted for being supported on a floor or ground surface. The upper portion is also adapted to mount to a fixture when removed from the lower portion and further includes an input connector for coupling to a monitoring device. The controller is in communication with the input connector, which is adapted for coupling the controller with a monitoring device for receiving data from the monitoring device for one of (1) storing, (2) monitoring, and (3) analyzing the received data. | 2008-09-25 |
20080234556 | METHOD AND APPARATUS FOR SENSING RESPIRATORY ACTIVITIES USING SENSOR IN LYMPHATIC SYSTEM - A respiratory monitoring system includes an implantable lymphatic sensor configured to be placed in a lymphatic vessel, such as the thoracic duct or a vessel branching from the thoracic duct, near the diaphragm. The implantable lymphatic sensor senses a signal indicative of respiratory activities. Examples of the signal include a diaphragmatic activity signal indicative of movement of the diaphragm and a transthoracic impedance signal indicative of pulmonary volume. In one embodiment, the respiratory monitoring system is incorporated into a cardiac rhythm management system that controls cardiac therapy delivery using the signal sensed by the implantable lymphatic sensor. | 2008-09-25 |
20080234557 | Mobile radio transmission unit - The invention relates to a mobile radio transmission unit for transferring data to a control and/or signal processing unit. According to the invention, provision is made for a mobile radio transmission unit for transferring data to a control or a signal processing unit, comprising a sensor arrangement for determining at least one component of a surrounding magnetic field. The sensor arrangement is connected to a monitoring entity which, from the at least one component, ascertains a variable that characterizes the surrounding magnetic field and prevents a transmission by an antenna of the radio transmission unit if the characteristic variable is below a threshold value. | 2008-09-25 |
20080234558 | METHODS AND SYSTEMS FOR PERFORMING A CLINICAL ASSESSMENT - The invention provides method and systems for performing clinical assessment of a patient that includes determining of a base clinical assessment for the patient by generating information on a clinical rating scale. At least one objective signal is recorded, and each objective signal involves an indicator corresponding to the state of the patient or the state of the patient's environment. Each objective signal is analyzed for generating a corresponding rating on the clinical rating scale. The clinical assessment of the patient may be provided by combining the information from the base clinical assessment with the information generated from analysis of each objective signal. In an embodiment, the clinical assessment may be based exclusively on information generated by analysis of each objective signal. The methods for performing clinical assessment of a patient may also be provided as computer program products having computer readable instructions embodied therein. | 2008-09-25 |
20080234559 | Analyte Meter Protectors and Methods - Analyte meter protectors, meters that include the same, and methods. | 2008-09-25 |
20080234560 | Optical measurement instrument for living body semiconductor laser installation for living body light measuring device - A living body measuring instrument having a sub-mount on which plural light-emitting devices oscillating at different wavelengths are mounted in proximity, one optical output monitoring device that detects the optical outputs of these light-emitting devices and a light source mounted on the same heat sink which are housed in one can-package, a light-receiving device that detects a signal from a living body, and a circuit that separates the optical output signals from the light-emitting devices, wherein at least one light-emitting device has a light-emitting layer including a In | 2008-09-25 |
20080234561 | System for in-vivo measurement of an analyte concentration - Human or animal body fluids can be measured in-vivo to determine analyte concentrations, such as glucose. The measurement system comprises an exchangeable sensor for in-vivo placement, a data carrier with calibration data for the sensor, a housing having a first chamber for receiving a sterile sensor and a second chamber for receiving a data carrier, and a base station that couples to the housing for transmitting measurement signals to an evaluation unit. Replacement sterile sensors can be packaged in a sterile package and the data carrier associated with the replacement sensor can be packaged in a non-sterile package. | 2008-09-25 |
20080234562 | Continuous analyte monitor with multi-point self-calibration - Analyte monitors and their methods of use. The analyte monitors include multiple calibration fluids which may have different known concentrations of an analyte, such as glucose. The analyte monitors may also include sensing or washing fluids. The analyte monitors are configured to be calibrated with the multiple calibration fluids to potentially provide a more accurate determination of analyte concentrations. The analyte monitors can be adapted to be self-calibrating with the multiple calibration fluids. | 2008-09-25 |
20080234563 | Device for and Method of Delivery and Removal of Substances in and From a Tissue or Vessel - The invention relates to a device ( | 2008-09-25 |
20080234564 | Electrophysiology therapy catheter - A mapping catheter is positioned in a heart chamber, and active electrode sites are activated to impose an electric field within the chamber. The blood volume and wall motion modulates the electric field, which is detected by passive electrode sites on the preferred catheter. Electrophysiology measurements, as well as geometry measurements, are taken from the passive electrodes and used to display a map of intrinsic heart activity. | 2008-09-25 |
20080234565 | Ambulatory Physiological Monitor Having A Patient-Activated Emergency Alert Cancellation Feature - An ambulatory physiological monitor ( | 2008-09-25 |
20080234566 | Recognizing a real world fiducial in a patient image data - Medical apparatus is described including a fiducial component and a position sensor. The component is recognizable as at least a part of a fiducial when appearing in image data of a patient. The component is attachable to the patient. The sensor is attachable to the component at a predetermined location and orientation on the component or is capable of being positioned adjacent the fiducial component without attachment thereto at a predetermined location and orientation. A storage medium is described containing a program which instructs the computer to recognize a predetermined shape of each of at least one portion of a position sensor as at least a part of a real-world fiducial in image data of a patient. The position sensor is adapted to provide position data. Medical apparatus which includes the position sensor and the storage medium is also described. | 2008-09-25 |
20080234567 | APPARATUS AND METHOD FOR PROVIDING A NONINVASIVE DIAGNOSIS OF INTERNAL BLEEDING - Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data. | 2008-09-25 |
20080234568 | BIOLOGICAL INFORMATION MONITORING APPARATUS - A biological information monitoring apparatus highly precisely observes a clothed subject who is taking any desired posture. The apparatus acquires information on positional displacements of the surface of a living body, by generating a high-frequency electromagnetic wave to radiate it into air, detecting the electromagnetic wave scattered by the surface of the living body, computationally determining the changes with time of the positional displacements of the surface of the living body from the state of propagation of said electromagnetic wave and computationally determining characteristic quantities of vibrations of the living body such as the pulse or the respiration from the changes with time as biological information. | 2008-09-25 |
20080234569 | Mri Probe for Prostate Imaging - A rectal probe adapted for ultrasound and magnetic resonance imaging of the prostate, comprising: a) an ultrasound imaging probe; b) an MRI probe comprising a first magnetic field source for creating a static magnetic field in an MRI imaging region outside the rectal probe, a second magnetic field source for creating a time-varying magnetic field which excites nuclei in the MRI imaging region, and a receiver for receiving NMR signals from the excited nuclei and generating MRI imaging data indicative thereof; and c) a link joining the ultrasound probe and the MRI probe. | 2008-09-25 |
20080234570 | System For Guiding a Medical Instrument in a Patient Body - The present invention relates to a medical system comprising a medical instrument to be guided in a patient body, ultrasound acquisition means using an ultrasound probe for acquiring a 3D ultrasound data set and X-ray acquisition means for acquiring a 2D X-Ray image, which comprises a projection of said medical instrument. The system in accordance with the invention further comprises means for localizing said ultrasound probe within a referential of said X-Ray acquisition means, means for providing a first localization of said medical instrument within a referential of the ultrasound acquisition means, means for converting said first ultrasound localization into a first X-Ray localization within the referential of said X-Ray acquisition means, means for providing a second X-Ray localization of the projection of said medical instrument in the two-dimensional X-ray image, means for mapping said 3D ultrasound data set with said 2D X-ray image in accordance with a transformation, which minimizes a distance between a projection of said first X-Ray localization on said 2D X-Ray image and said second X-Ray localization and means for generating and displaying a bi-modal representation of said medical instrument, in which said 2D X-ray image and said mapped 3D ultrasound data are combined. | 2008-09-25 |
20080234571 | Method and Apparatus For Generating Multiple Studies - Information indicative of multiple regions of the anatomy of a patient ( | 2008-09-25 |
20080234572 | FIDUCIAL MARKER WITH ABSORBABLE CONNECTING SLEEVE AND ABSORBABLE SPACER FOR IMAGING LOCALIZATION - A fiducial marker for use in the body of a living being to enable the localization of targeted internal tissue. The implant is in the form of an elongated, e.g., rod-like, spacer located between pair of end members, e.g., gold cylinders, and held together by an elongated sleeve, e.g., a heat-shrinkable sleeve. When so connected portions of the end members are exposed, i.e., extend beyond the ends of the sleeve. The outer surface of the exposed portions of each of the end members is textured, e.g., grooved, to provide resistance to migration when the marker is implanted. The spacer and the sleeve are each be formed of an absorbable material. | 2008-09-25 |
20080234573 | SYSTEM AND METHODS FOR DETERMINING THE ORIENTATION AND POSITION OF A BONE-IMPLANTED ANCHOR - In another aspect, the present invention relates to a method for determining the position and orientation of an anchor attached to the skull of a patient from a topographic image of the anchor acquired therefrom. In one embodiment, the method includes the steps of simulating an image of the anchor that matches the acquired topographic image of the anchor, determining the position and orientation of the anchor from the simulated image of the anchor, and determining the position and orientation of the anchor in the acquired topographic image of the anchor from the position and orientation of the anchor determined from the simulated image of the anchor. The simulating step comprises the step of modeling the anchor with an object that has a geometric shape simpler than that of the anchor. | 2008-09-25 |
20080234574 | Tissue Detection and Ablation Apparatus and Apparatus and Method For Actuating a Tuner - The present invention relates to an apparatus for classifying and/or ablating tissue. By directing microwave radiation through a probe ( | 2008-09-25 |
20080234575 | Method and device for making correction information available - The invention relates to a method and a device for making correction information for correcting a guidance direction of an instrument. Based on a current position of the tip of the instrument and the current guidance direction of the instrument and the position of a target point in an object, a first straight line indicating the current guidance direction and a second straight line defined by the tip of the instrument and the target point in the object are determined. The second straight line intersects the first straight line and indicates the desired guidance direction. Based on the position of the first and second straight lines relative to one another, a digital item of correction information is specified, wherein the correction image has a correction diagram located in a plane in the perspective of the current guidance direction of the instrument. | 2008-09-25 |
20080234576 | SYSTEM AND METHOD TO TRACK MOVEMENT OF A TOOL IN PERCUTANEOUS REPLACEMENT OF A HEART VALVE - A system and method to track movement of a tool in percutaneous replacement of a heart valve of a subject is provided. The system includes an imaging system, a navigation system operable to track movement of the tool through the patient and to illustrate a representation of a position the tool in spatial relation relative to images acquired by the imaging system, and a controller. The controller is operable to identify one of a series of pathways to move the tool through a patient in percutaneous replacement of the heart valve, to identify a sequence of models illustrative of the one of the plurality of pathways, to detect the position of the tool within a threshold of one of the models in the sequence, and to generate display including a representation of the tool superimposed relative to the model within the threshold. | 2008-09-25 |
20080234577 | Diagnostic Ultrasound System with Articulating Flat Panel Display - An ultrasonic diagnostic imaging system includes a flat panel display for viewing images produced by the ultrasound system. The flat panel display is mounted to the ultrasound system by an articulating arm assembly having a lower arm with a fixed elevation pivotally connected to the ultrasound system and an upper arm pivotally connected to the lower arm at one end and pivotally connected to the flat panel display at the other end. The upper arm includes a 4-bar linkage which enables the flat panel display to be raised and lowered, and a pneumatic piston which provides a counter-weight to the weight of the flat panel display. | 2008-09-25 |
20080234578 | Multi-modality mammography reconstruction method and system - A method, system, and software are provided for joint reconstruction of three-dimensional images using multiple imaging modalities. In an exemplary embodiment, the present approach includes providing a first dataset acquired via a first imaging technique or a first image generated from the first dataset, providing a second dataset acquired via a second imaging technique or a second image generated from the second dataset, and generating a volumetric dataset by extracting information from the first and second datasets or images. The first imaging technique may have better resolution than the second imaging technique in a first direction, and the second imaging technique may have better resolution than the first imaging technique in a second direction. There is provided a system and one or more tangible, machine readable media for performing the act of generating the volumetric dataset by extracting information from the first and second datasets or images. | 2008-09-25 |
20080234579 | Interactive Ultrasound-Based Depth Measurement For Medical Applications - A device for determining the internal structure of a bone along a path directed into the bone (or other tissue) is disclosed. The device comprises a nozzle fluidically connected to a liquid reservoir for providing a liquid jet directed at the bone in the direction of the path; an ultrasonic transducer for generating ultrasonic waves through the liquid jet and for detecting echoes of the ultrasonic waves caused by changes in the acoustical impedance in the bone characterizing changes in the structure of the bone along the path; and an analyzer for interpreting the echoes into meaningful information relating to the location of the structural changes along the path. | 2008-09-25 |