38th week of 2014 patent applcation highlights part 137 |
Patent application number | Title | Published |
20140272884 | Reward Based Ranker Array for Question Answer System - Mechanisms are provided for configuring a ranker array of a question and answer (QA) system. An initial configuration of a ranker array of the QA system is generated which comprises a plurality of rankers with each ranker applying a statistical classification function to candidate answers generated by the QA system. A training question is input to the QA system to generate a training candidate answer set and the ranker array is applied to the training candidate answer set to generate, for each ranker in the ranker array, a ranked listing of candidate answers. For each ranker in the ranker array, a correctness of a corresponding ranked listing of candidate answers is determined and the ranker array is reconfigured based on results of the determined correctness of the corresponding ranked listing of candidate answers for each ranker in the ranker array. | 2014-09-18 |
20140272885 | LEARNING MODEL FOR DYNAMIC COMPONENT UTILIZATION IN A QUESTION ANSWERING SYSTEM - Mechanisms are provided in a data processing system for utilizing algorithms based on categories in a question answering system. The mechanisms capture a history of performance and correctness metrics for identifying efficiency of respective algorithms for finding answers to questions in respective question categories in a question answering system. The mechanisms determine sets of algorithms to use for respective question categories according to efficiency and correctness analysis. The mechanisms determine a question category of a given input question and execute a set of algorithms corresponding to the question category of the given input question that meet an efficiency threshold to contribute to finding a correct answer for the given input question. | 2014-09-18 |
20140272886 | System and Method for Gamefied Rapid Application Development Environment - A gamification application development system. The system has specialized game development toolbars and a suite of tools. The tools are used to create gamification of continuing education training and are adapted to be used by individuals who are not game designers. | 2014-09-18 |
20140272887 | INTERACTIVE ASYNCHRONOUS EDUCATION - A system for asynchronous education content delivery is disclosed. A data store comprises education content associated with a course of learning and sequence data specifying an order for presentation of the content. Education content comprises video recordings of lectures, questions, and model responses. The system receives students' requests for data, queries the database in order to identify the appropriate content, and transmits the content. The system may require that a student provide input in response to a recorded prompt in order to proceed with a planned course of study. The student's inputs are made available to other students and teachers for further review and critique. | 2014-09-18 |
20140272888 | Engaging a Plurality of Users in an Interactive Activity in an Educational Environment - Engaging a plurality of users in an interactive activity in an educational environment includes receiving information that corresponds to an annotation entered by a first user of a first subordinate device of a plurality of subordinate devices. A representation of the annotation entered by the first user while the first user is annotating on the first subordinate device is presented, using a processor, on an instructor device. Information is received that corresponds to an annotation entered by a second user of a second subordinate device of the plurality of subordinate devices. A representation of the annotation entered by the second user is presented on the second the instructor device using the processor while the second user is annotating on the second subordinate device and while the instructor device simultaneously presents the representation of the annotation entered by the first user on the first subordinate device. | 2014-09-18 |
20140272889 | COMPUTER IMPLEMENTED LEARNING SYSTEM AND METHODS OF USE THEREOF - A learning system including an information bus, a student information system, a content repository, a learning content management system, and a learning engine is provided. The student information system, the content repository, the learning content management system, and the learning engine each publish messages to the information bus and subscribe to messages from the information bus. The learning system may present and track the efficacy of both learning map-based course materials and traditional course materials. Methods of using a learning system and creating course learning maps are also presented. | 2014-09-18 |
20140272890 | CONFERENCING ORGANIZER - A conference mode screen is displayed on a computing device. The conference mode screen includes a list of students. A selection of a student from the list of students is received from a user. In response to the selection of the student, a list of action buttons is presented. The action buttons may correspond to actions that can be taken by a teacher during a conference with the selected student. A selection of an action button from the list of action buttons is received. The selected action button corresponds to an action taken by the teacher during the conference with the selected student. An indicator of the action is stored in association with a student identifier for the selected student and a sequence indicator. | 2014-09-18 |
20140272891 | SYSTEM AND METHOD FOR REMOTE FITNESS TRAINING - Systems, methods, and apparatus for remote education. In one aspect, the disclosed method includes the steps of recording, at an instructor device, a lesson plan, the lesson plan including at least one lesson service identifier, associating the lesson plan with at least one student, storing, in a database accessible to an application server, the lesson plan and the at least one student association of the lesson plan, receiving, at a student device associated with the lesson plan, the associated lesson plan, determining a physical location of the student device, identifying a facility service identifier associated with the physical location, comparing the lesson service identifier associated with the lesson to the facility service identifier associated with the physical location, and revising the lesson in accordance with the comparison. | 2014-09-18 |
20140272892 | ON-LINE CUSTOM COURSE BUILDER - A custom course builder computer application allowing users to search, view, preview, and select e-learning course components based on specific achievement objectives to assemble e-learning custom courses using a repository of content and assessment items. The custom courses may be used for the particular curriculum or may be shared with other schools or institutions. | 2014-09-18 |
20140272893 | COLLABORATIVE ASYNCHRONOUS ONLINE LEARNING - A system and method of e-learning involving an online asynchronous interdisciplinary project-based curriculum where students are provided with learning content relating to an interdisciplinary project and complete role-based tasks relating to the project. The students work collaboratively to complete the project thereby developing core learning skills that foster the growth of each student's social communication skills. | 2014-09-18 |
20140272894 | SYSTEM AND METHOD FOR MULTI-LAYERED EDUCATION BASED LOCKING OF ELECTRONIC COMPUTING DEVICES - Systems, methods and computer program products for managing multi-layer rewards and multi-device control in reward-based learning experiences for users having mobile electronic devices. These technologies require that a user complete education modules using his or her mobile electronic device before receiving a reward, such as access of certain features of the mobile electronic device, one layer at a time. A more difficult education module and a bigger reward may be associated with a higher layer. These technologies also ensure that when a user has a plurality of mobile electronic devices, the user may complete an education module on one or more of these electronic devices and the user would not receive a reward from any of these electronic devices until the user has completed the education module. | 2014-09-18 |
20140272895 | COLLABORATIVE LEARNING ENVIRONMENT - A collaborative learning environment receives an assignment from a first student user identity. In response to receiving the data representing the submission of the assignment, the collaborative learning environment sends a notification that the first student user identity has submitted the assignment to a plurality of student user identities and an instructor user identity, and makes the assignment and a comment module associated with the assignment accessible to the plurality of student user identities and the instructor user identity. The collaborative learning environment receives a comment from a second student user identity in the comment module. The collaborative learning environment receives data representing an evaluation of the assignment from the instructor user identity. After receiving the data representing the evaluation of the assignment, the collaborative learning environment sends the data representing the evaluation of the assignment to the first student user identity and to the second student user identity. | 2014-09-18 |
20140272896 | Classroom Management Application and System - A classroom management system which includes a centralized cloud infrastructure, a first user interface having a geo-locating device in communication with the centralized cloud infrastructure, and a second user communication interface in communication with the centralized cloud infrastructure to define authorized users and authorized locations. The centralized cloud infrastructure transmits an in-attendance signal for each authorized user located in the authorized location based on data received from the geo-locating device to the second user communication interface. | 2014-09-18 |
20140272897 | METHOD AND SYSTEM FOR BLENDING ASSESSMENT SCORES - A method and system for blending assessment scores for expressing the blended score as a single score while taking into account the non-compensatory nature of each assessment is disclosed. The method includes executing a test of a cognitive characteristic and a separate test of a non-cognitive characteristic. A cognitive test score and a non-cognitive test score are obtained from executing the test. The cognitive score and the non-cognitive score are blended using a non-compensatory blending scheme for outputting a blended score. | 2014-09-18 |
20140272898 | SYSTEM AND METHOD OF PROVIDING COMPOUND ANSWERS TO SURVEY QUESTIONS - Embodiments disclosed herein include systems and methods which allow for the creation of online surveys in which answers to compound questions may be efficiently gather from online survey respondents using a space-efficient user interface configuration. The space-efficient user interface configuration reduces the perceived and/or actual time and effort needed to complete the survey, and allows the user to easily review previously submitted questions. | 2014-09-18 |
20140272899 | CIVICS TESTING - Techniques for enhancing an individual's knowledge of civics topics in an interactive manner are described herein. In particular implementations, a user may interact with a computing device, such as a smart phone, tablet computer, or laptop computer, to take a test related to civics topics and to view information about others that have taken the test. For example, a user may view an average test score of others of a particular geographical region or group, a test score of an elected representative, a test score of a friend, and so on. | 2014-09-18 |
20140272900 | Synergistic Computer-Based Testing System (SCBTS) - This disclosure is drawn to methods, systems, devices and/or apparatus related to synergistic computer-based testing system. Specifically, the disclosed methods, systems, devices and/or apparatus relate to computer-based testing of one or more members of a group in a synergistic manner. In some examples, several test takers may form a group such that the group may take a test as a group. In this manner, the questions comprising the test may be completed by any test taker in the group. In some examples, some questions may be locked by a test taker such that others in the group may not provide an answer to the locked questions. | 2014-09-18 |
20140272901 | METHODS AND APPARATUS FOR PROVIDING ALTERNATIVE EDUCATIONAL CONTENT FOR PERSONALIZED LEARNING IN A CLASS SITUATION - In one example embodiment, the learning content management system includes a processor configured to determine a local level of understanding for a learning object based on a plurality of received inputs. The local level of understanding indicates a collective understanding level of the learning object by a plurality of users. Each of the plurality of received inputs indicates a level of understanding of the learning object by one of the plurality of users. The processor is further configured to determine a global level of understanding based on the determined local level of understanding. | 2014-09-18 |
20140272902 | SYSTEM AND METHOD FOR GENERATING AND DISTRIBUTING A SURVEY - A system and method for generating and distributing a survey includes an executable survey generation application. The survey generation application permits a survey designer to select at least one survey component template associated with a type of survey question from a repository pane of the survey generation application. Selection of the survey component template creates a corresponding survey component within at least one of a working pane and a review pane of the survey generation application. The survey designer may edit the survey component to include desired survey content by entering desired parameters within a data entry pane of the survey generation application. The completed survey may then be distributed to desired recipients by the survey designer activating a publish control of the survey generation application. | 2014-09-18 |
20140272903 | SYSTEM FOR IDENTIFYING ORIENTATIONS OF AN INDIVIDUAL - A system for identifying preferences of a user and demonstrating the preferences in a graphical manner, the system comprising an input apparatus to facilitate recording of answers to a plurality of groups of questions from the user, a processing apparatus to facilitate calculation of output parameters, each of the output parameters is calculated by averaging answers to each of the plurality of groups of questions and a graphical apparatus to display the output parameters of each of the user in a graphical format, wherein each of the output parameters is depicted as its affinity to two diverse poles. | 2014-09-18 |
20140272904 | COMBINING DIFFERENT TYPE COERCION COMPONENTS FOR DEFERRED TYPE EVALUATION - In a method of answering questions, a question is received, a question LAT is determined, and a candidate answer to the question is identified. Preliminary types for the candidate answer are determined using first components to produce the preliminary types. Each of the first components produces a preliminary type using different methods. A first type-score representing a degree of match between the preliminary type and the question LAT is produced. Each preliminary type and each first type-score is evaluated using second components. Each of the second components produces a second score based on a combination of the first type-score and a measure of degree that the preliminary type matches the question LAT. The second components use different methods to produce the second score. A final score representing a degree of confidence that the candidate answer matches the question LAT is calculated based on the second score. | 2014-09-18 |
20140272905 | ADAPTIVE LEARNING SYSTEMS AND ASSOCIATED PROCESSES - Adaptive learning systems and process are described herein for providing an online learning environment for delivering a course comprising a plurality of learning activities having different levels of difficulty to a user in a manner that supports user motivation. The systems and processes described herein dynamically adapt the selection of learning activities to display to the user to find/maintain a personally selected challenge for the user. Learning activities require user input and can be used to test a user's proficiency of the corresponding subject matter. The system can also support user motivation by affording a user multiple opportunities to correctly complete a learning activity as well as providing hints to the user to increase the user's chance of successfully completing a learning activity on a subsequent attempt. | 2014-09-18 |
20140272906 | MASTERY-BASED ONLINE LEARNING SYSTEM - An online learning system includes a student engine, a courses engine and a reports engine. The student engine processes identification information for students registered in an online university. The courses engine includes a competencies engine, a challenges engine and a milestones engine. The competencies engine organizes online courses into topics of study. The challenges engine provides one or more series of open-ended questions on the topics of study. The milestones engine provides a series of multiple choice questions on the topics of study. The multiple choice questions are only accessible when a percentage of the open-ended questions in each of the series of open-ended questions are answered correctly. The reports engine provides data relating to student performance. | 2014-09-18 |
20140272907 | METHOD FOR COMMUNICATING AND ASCERTAINING MATERIAL - A method for communicating and ascertaining material includes: (a) providing a plurality of assemblages, wherein an assemblage is comprised of a plurality of intelligences; (b) providing an issue and a plurality of material to the plurality of assemblages; (c) communicating and ascertaining the plurality of material between the intelligences of each plurality of assemblage to reach at least one outcome to the issue; (d) reorganizing the plurality of assemblages from a plurality of previous assemblages to a plurality of subsequent assemblages; (e) integrating the at least one outcome of each of the previous assemblages to each of the subsequent assemblages; (f) communicating and ascertaining the plurality of modified material by the intelligences of the plurality of transformed assemblages to reach at least one modified outcome to the issue; and (g) reiterating (d) through (f) until a previous modified outcome of plurality of previous assemblages and a subsequent modified outcome of a plurality of subsequent assemblages are analogous is provided. | 2014-09-18 |
20140272908 | DYNAMIC LEARNING SYSTEM AND METHOD - The invention contemplates a real time learning system and method with machine executed steps of creating a student learning profile based upon testing the student, and dynamically optimizing the learning profile based upon student responsive data to instruction. The method includes dynamically optimizing a curriculum based upon the dynamically optimized learning profile (DOLP) of the student and providing lessons or lesson guidance for the student based upon the dynamically optimized curriculum (DOC). The DOLP stores data including real time frequency curves of affect value versus success rate for multiple content delivery methods (DMs). Frequency curves of multiple DMs are compared and optimal DM amounts obtained. Affect value is a measurement of affective state based upon sensor data or determined sensor-free. Affective state may be engaged concentration, boredom, confusion, frustration, etc. A dynamically optimized teaching profile (DOTP) is contemplated. The DOLP and DOTP are based upon preliminary profiles. | 2014-09-18 |
20140272909 | Results of Question and Answer Systems - Mechanisms are provided for modifying an operation of a question answering (QA) system. An input question is received and processed to generate at least one query to be applied to a corpus of information. The at least one query is applied to the corpus of information to generate candidate answers to the input question from which a final answer is selected for output. A training engine modifies, using a machine learning technique that compares the final answer to a known correct answer for the input question, at least one of logic or configuration parameters of the QA system for at least one of the processing of the input question to generate the at least one query, applying of the at least one query to the corpus of information to generate the candidate answers, or the selecting of the final answer from the candidate answers. | 2014-09-18 |
20140272910 | SYSTEM AND METHOD FOR ENHANCED TEACHING AND LEARNING PROFICIENCY ASSESSMENT AND TRACKING - A system and method for assessing and tracking learning proficiency that includes presenting a problem for solution by a student in a workspace displayed on a student processing device and assessing a plurality of lines entered by the student in the workspace for correctness and correspondingly providing scores for each of the plurality of lines The system and method also includes modifying a plurality of assessed skill levels each based on the scores for each of the plurality of lines. | 2014-09-18 |
20140272911 | EDUCATIONAL NETWORK BASED INTERVENTION - Methods and systems for educational intervention are disclosed. The methods can include receiving a user response and analyzing the user response and other user data to determine a user typology. The user typology can be compared with risk data that indicates the user's risk of failing to achieve a target outcome based on the identified user typology. If the user's risk of failing to achieve the target outcome exceeds a desired level, a mitigation plan can be generated and provided to the user to thereby facilitate in the attainment of the target outcome. | 2014-09-18 |
20140272912 | METHOD OF ONLINE LEARNING FOR MIDDLE SCHOOL CURRICULUM - A comprehensive electronic learning program that evaluates student's learning style preferences and assesses the student's proficiency periodically prior to and/or during an electronic learning course. The information is used to determine subsequent content and supplementary resources for the next section of the course based on the student's learning style preferences. | 2014-09-18 |
20140272913 | METHODS AND APPARATUS FOR EFFICIENT LEARNING - A learning support method is provided. First, an n-th review of each of a plurality of learned items is provided, and the n-th review comprises at least one question. Then, an (n+1)-th review of each of the plurality of learned items is provided after a period of time determined based on an n-th memory strength of each of the plurality of learned items and a memory retention threshold. The n-th memory strength of each of the plurality of learned items is determined based on answer time and an answer to each of the at least one question. | 2014-09-18 |
20140272914 | Sparse Factor Analysis for Learning Analytics and Content Analytics - A mechanism for facilitating personalized learning. A computer receives graded response data including grades that have been assigned to answers provided by learners in response to a set of questions. Output data is computed based on the graded response data using a latent factor model. The output data includes at least: an association matrix that defines a set of K concepts implicit in the set of questions, wherein K is smaller than the number of questions, wherein, for each of the K concepts, the association matrix defines the concept by specifying strengths of association between the concept and the questions; and a learner knowledge matrix including, for each learner and each of the K concepts, an extent of the learner's knowledge of the concept. The computer may display a visual representation of the association strengths in the association matrix and/or the extents in the learner knowledge matrix. | 2014-09-18 |
20140272915 | ACCELERATION SENSATION PRESENTATION APPARATUS, ACCELERATION SENSATION PRESENTATION METHOD, AND ACCELERATION SENSATION PRESENTATION SYSTEM - An acceleration sensation presentation apparatus includes: a frame to be worn on the head of a user; at least one or more weights provided to the frame; and a vibration driving unit configured to vibrate the weight to be moved. | 2014-09-18 |
20140272916 | MINIATURE UNIVERSAL DYNAMOMETER EDUCATIONAL TOOL - A miniature universal dynamometer for use in teaching and measuring horsepower of scaled down electronic vehicles and DC generators is provided. The miniature universal dynamometer relates generally to electro-mechanical vehicles that use DC energy and DC generators that produce electrical power. This miniature universal dynamometer relates specifically to vehicles that easily and quickly demonstrate to students and auto workers the design and horsepower used by the electronic vehicles in moving vehicles on various roadways. The device also utilizes a switch which allows the device to measure horsepower required to produce electrical power from a DC generator. | 2014-09-18 |
20140272917 | GLASS NON-GLARE MARKER BOARD - An improved marker board with a glass substrate, a writing surface, and a rear surface. The writing surface roll coated or screen printed with a ceramic frit that is fired into the writing surface. An opaque ink is disposed on the rear surface. The ceramic frit provides glare reduction in high light environments, while maintaining ease of erasability and avoidance of ghosting. | 2014-09-18 |
20140272918 | WHITEBOARD ASSEMBLY - A white board assembly including a wall mountable base structure upon which a frame structure constructed of a plurality of frame members that each have grooves defining a panel receiving space into which a display panel may be inserted through and removed from a slot provided by at least one of the frame members. The frame structure is affixed to the base structure in such a way that allows the frame structure to be moved between an open and closed position. A writing panel is mounted to at least one of the base structure and the frame structure in such a way that when the frame structure is in the closed position, the writing panel is concealed and the display panel is displayed. When the frame structure is in the closed position, the writing panel is displayed. | 2014-09-18 |
20140272919 | CORE BOARD - The present invention is an improved core board, being lightweight for convenient use and having dual performance with two sides capable of accepting application of inks, paint, markings, lettering, design and glues, as well as being suitable for cutting and mounting. | 2014-09-18 |
20140272920 | Administration And Monitoring Of Nitric Oxide In Ex Vivo Fluids - Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration. | 2014-09-18 |
20140272921 | METHODS AND REAGENTS FOR MAINTAINING THE VIABILITY OF CANCER CELLS IN SURGICALLY REMOVED TISSUE - A composition and method for generating reagents and the composition of these reagents for the stabilization and preservation of viability of cancer tissue which has been surgically excised and the suspension and/or termination of apoptosis (cell death) by significant modulation of cell metabolism by low molar concentrations of synergistic chemistries and hormonal growth enhancers while maintaining normal gene expression patterns of the surgically excised tissue. | 2014-09-18 |
20140272922 | ORGAN/TISSUE DISSECTION BASIN SYSTEM - A basin system is provided comprising a basin, a tissue supporting plate, a platform ring and a suspension rod, the basin system configured to permit a single clinician to effectively and accurately perform the dissection with minimal movement of the resected tissue within the basin system, wherein the platform ring and the suspension rod each comprise a plurality of grooves, permitting a clinician to secure resected tissue within the basin system and tie it down in three dimensions. | 2014-09-18 |
20140272923 | TRANSPORTER WITH A GLUCOSE SENSOR FOR DETERMINING VIABILITY OF AN ORGAN OR TISSUE - An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue with a perfusate; and a sensor operatively connected to the perfusion circuit. The sensor includes a solid support to which is attached a recognition molecule that permits detection of the target agent. The recognition molecule specifically binds to the target agent in the presence of the target agent but not significantly to other agents. The sensor also includes an enzyme that can catalyze the conversion of a substance to glucose. In the presence of the target agent the enzyme can convert the substance into glucose, which can then be detected and optionally measured by the sensor. | 2014-09-18 |
20140272924 | TRANSPLANTATION AND GROWTH OF HUMAN FETAL ORGANS IN NON-HUMAN ANIMAL HOSTS - Embodiments described herein relate generally to devices, systems and methods for transplanting and growing human fetal organs within non-human animal hosts. In some embodiments, a method for transplanting an organ from a human fetus in a non-human animal host includes fluidically coupling the fetal organ to the blood circulation system of an immunocompromised non-human animal host such that the organ receives arterial blood flow from the non-human animal host. The blood pressure of the arterial blood flow entering the fetal organ is controlled to be compatible with the blood pressure of the organ from the human fetus. In some embodiments, the blood pressure of the blood flow to the fetal organ is controlled using a blood flow control device that includes an inflatable cuff in pressure contact with a blood vessel of the non-human animal host. | 2014-09-18 |
20140272925 | Plasma Separation Apparatus, Method and System - A blood fractionating apparatus that enables aseptic fractionation and storing of fractionated blood components, comprises a centrifuge tube including three chambers separated by constricted sealable passages, an open operative upper end chamber, a closed operative lower end chamber and a middle chamber defined between the upper end chamber and the lower end chamber and connected by means of the sealable passages. A stopper with a flapper valve is provided at the opening of the upper end chamber to control flow of fluid to and from the chambers. This apparatus enables separating the chambers to obtain a hermetically sealed operative lower chamber containing the corpuscle component and a hermetically sealed middle chamber containing the plasma component that can be stored at ambient temperature. | 2014-09-18 |
20140272926 | SULFUR MANAGEMENT FOR PROCESSES AND CONTROL SYSTEMS FOR THE EFFICIENT ANAEROBIC CONERSION OF HYDROGEN AND CARBON OXIDES TO ALCOHOLS - High conversion efficiency processes are disclosed for the anaerobic bioconversion of syngas to alcohol by microorganisms having metabolic processes that utilize sulfur in limited amounts. The processes remove hydrogen sulfide from the gas leaving the bioreactor assembly by forming sulfur compounds that are beneficial to the microorganisms. The sulfur compounds can be returned to the bioreactor assembly to meet a portion of microorganism sulfur demand. | 2014-09-18 |
20140272927 | METHODS, DEVICES, AND SYSTEMS FOR PROCESSING MULTIPLE ASSAYS BACKGROUND - Methods, devices, and systems for performing polymerase chain reaction (PCR) amplification and melt data acquisition according to a single slug approach in which a single slug in a microfluidic channel fills an entire thermal zone of the microfluidic channel, and the thermal zone used for both PCR temperature cycling and melt data acquisition. A detector may be configured to detect fluorescence from the thermal zone during the PCR temperature cycling for real-time PCR and/or during temperature ramping in the melt data acquisition. Slug position control may be achieved by detecting leading or trailing edges in a slug build target zone into which a slug passes after passing through the thermal zone. The single slug approach may break coupling between one or more events of the PCR amplification and melt data acquisition and enable events to be independently optimized. | 2014-09-18 |
20140272928 | SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES - Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity. | 2014-09-18 |
20140272929 | METHODS AND SYSTEMS FOR IMPROVED CAVITATION EFFICIENCY AND DENSITY, CANCER CELL DESTRUCTION, AND/OR CAUSING A TARGET OBJECT TO BE A CAVITATION NUCLEUS - A method of causing an object to act as a cavitation nucleus comprising the steps of providing a sound energy source capable of generating a sound energy over a plurality of frequency ranges, providing a target object contained in a liquid, coupling the sound energy source to the liquid, determining a specific frequency range, within the frequency ranges, that resonates the target object, and exposing the target object to sound energy at the specific frequency range to cause the target object to act as a cavitation nucleus. | 2014-09-18 |
20140272930 | Compositions And Methods For Determining Resistance To Inhibitors Of Virus Entry Using Recombinant Virus Assays - The invention provides a method for determining whether a human immunodeficiency virus is resistance to a viral entry inhibitor. The methods are particularly useful for determining resistance to inhibitors that act by a non-competitive mechanism. In certain aspects, the methods comprise determining whether an HIV population is resistant to an HIV entry inhibitor, comprising determining a log-sigmoid inhibition curve comprising data points for entry of the HIV population in the presence of varying concentrations of the HIV entry inhibitor, wherein if the entry of the HIV population cannot be completely inhibited by the HIV entry inhibitor, the HIV population is resistant to the HIV entry inhibitor. | 2014-09-18 |
20140272931 | HCV CORE LIPID BINDING DOMAIN MONOCLONAL ANTIBODIES - The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection. | 2014-09-18 |
20140272932 | HCV NS3 RECOMBINANT ANTIGENS AND MUTANTS THEREOF FOR IMPROVED ANTIBODY DETECTION - The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of HCV antibodies. More specifically, the present invention describes specific NS3 antigens that can be used for the detection of anti-HCV antibodies. | 2014-09-18 |
20140272933 | HCV ANTIGEN-ANTIBODY COMBINATION ASSAY AND METHODS AND COMPOSITIONS FOR USE THEREIN - The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a test sample. | 2014-09-18 |
20140272934 | DENDRIMERIC DYE-CONTAINING OLIGONUCLEOTIDE PROBES AND METHODS OF PREPARATION AND USES THEREOF - The invention provides novel oligonucleotide probes that have dendrimeric dyes useful for detecting and analyzing biological samples, and compositions and methods thereof. The dendrimeric dye-containing oligonucleotide probes are useful for high sensitivity fluorescence in situ hybridization (FISH) of nucleic acids such as DNA and RNA. | 2014-09-18 |
20140272935 | MIXING OF FLUIDS IN FLUIDIC SYSTEMS - Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active to components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids. | 2014-09-18 |
20140272936 | ADULTERATION TESTING OF HUMAN MILK - The present invention provides a method for screening human milk for an adulterant, e.g., non-human milk and infant formula, as well as methods of making human milk compositions free of an adulterant, e.g., human milk fortifiers and standardized human milk formulations. | 2014-09-18 |
20140272937 | Low Resource Processor Using Surface Tension Valves for Extracting, Concentrating, and Detecting Whole Cells - Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of whole cells. | 2014-09-18 |
20140272938 | DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION - Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens. | 2014-09-18 |
20140272939 | ASSAY METHODS - The present invention is directed to methods for improving assay specificity and performance in binding assays. | 2014-09-18 |
20140272940 | METHODS FOR DETECTION OF MULTIPLE TARGET NUCLEIC ACIDS - The present disclosure, in some embodiments, relates to compositions and methods for detection of multiple target nucleic acid sequences by a single nucleic acid amplification based assay (e.g. PCR). Compositions comprising two or more primers are described for multiple target nucleic acid detection. Methods for differential detection of microorganisms (including strains/serovars/subtypes thereof) and cell types comprise a single step method to detect a signature of target nucleic acid sequences comprising: two, three or more target nucleic acids that are uniquely present in a microorganism/strain/serovar/subtype and/or cell and absent in other closely related organisms/cells. Embodiments relate to methods of diagnosis of diseases or conditions that can be detected by detecting the presence of two or more nucleic acid target markers. | 2014-09-18 |
20140272941 | ROTATABLE FLUID SAMPLE COLLECTION DEVICE - A sample collection device for a fluid sample includes: a body including a capillary channel having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; an air vent located in the vicinity of the second end and in fluid communication with the capillary channel; a barrier positioned within the capillary channel to prevent flow of the fluid by capillary action thereacross; and features on opposing sides of the body to form an axis of rotation, which is substantially perpendicular to the overall direction of the capillary channel from the first end to the second end. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a sample manipulation device to bring the first end into position with the sample manipulation device. | 2014-09-18 |
20140272942 | Methods of Detecting Influenza Virus - Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method including measuring the enzymatic activity of neuraminidase (NA) in the sample under one or more differentiating conditions selected from the group consisting of pH, binding to anti-NanA antibody, size exclusion, hemagglutinin (HA) binding, chemical inhibition, and combinations thereof. | 2014-09-18 |
20140272943 | RAPID AND HIGHLY FIELDABLE VIRAL DIAGNOSTIC - The present invention relates to a rapid, highly fieldable, nearly reagentless diagnostic to identify active RNA viral replication in a live, infected cells, and more particularly in leukocytes and tissue samples (including biopsies and nasal swabs) using an array of a plurality of vertically-aligned nanostructures that impale the cells and introduce a DNA reporter construct that is expressed and amplified in the presence of active viral replication. | 2014-09-18 |
20140272944 | ONE-STEP PROCEDURE FOR THE PURIFICATION OF NUCLEIC ACIDS - The present invention is a new and non-obvious method for the improved and simplified purification of nucleic acids. | 2014-09-18 |
20140272945 | METHOD FOR MANUFACTURING MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE USING TWO KINDS OF PARTICLE, AND MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE MANUFACTURED BY MEANS OF SAME - Disclosed herein are a method for manufacturing a multi-functional bio-material conjugate used as a biosensor for detecting microorganisms, and the like, and a multi-functional bio-material conjugate manufactured by means of the same. The method for manufacturing a multi-functional bio-material conjugate includes: (a) coating a first nanoparticle having magnetic or fluorescent characteristics with protein; (b) manufacturing a conjugate by adsorbing a second nanoparticle having metallic characteristics onto the first nanoparticle coated with protein; and (c) manufacturing the multi-functional bio-material conjugate by adsorbing a bio-material onto the conjugate. The method for manufacturing a multi-functional bio-material conjugate according to the present invention may prevent precipitation of the nanoparticles, easily immobilize the bio-material, and manufacture a bio-material conjugate having multiple functions, by using two kinds of the particles. In addition, the multi-functional bio-material conjugate manufactured by the present method may be used to detect microorganisms at up to a concentration of 10 | 2014-09-18 |
20140272946 | Methods and Systems For DNA-Based Detection And Reporting - Methods, systems, and devices for the detection and notification of chemical, biological, radiological, nuclear, and/or explosive agent. The detection and notification system uses aptamers bound to a catalyst that is activated when the aptamer binds to the agent. The activated catalyst acts on a substrate to create a signal that is detected, indicating the presence of the agent. For example, the system can be a glove worn by a user that includes a catalyst/substrate pair that, in the presence of the target agent, produces a colorimetric and/or fluorescent signal in a time-efficient manner. | 2014-09-18 |
20140272947 | METHODS AND COMPOSITIONS FOR SCREENING MODULATORS OF ONCOGENE-INDUCED SENESCENCE - A high-throughput method for identifying a compound or biomolecule that modulates cell senescence involves simultaneously measuring in a cell population exposed to the test compound or biomolecule, the expression of a senescence marker and cell number, wherein each well contains a single test compound; and determining from said simultaneous measurements whether the test compound increases or decreases cell senescence. In various embodiments, the method is useful is identifying compounds that delay the aging process of normal healthy cells, or identifying a compound useful as a tumor suppressor or identifying a compound useful in the treatment of cancer. | 2014-09-18 |
20140272948 | HIERARCHICAL ASSEMBLY OF OPTICAL MAPS - The invention generally relates to optical maps and particularly to computationally tractable methods of assembling large numbers of single molecule maps by dividing the maps into smaller groups of maps within which all of the maps are similar to one another by some metric. For each group, all of the maps are assembled into contigs. The resulting contigs are then assembled into one or more genome assemblies. By dividing the maps into groups, a number of comparison operations required for assembly is reduced and, since each group of maps can be assembled into a contig in a discrete operation, the overall assembly operation can be parallelized. | 2014-09-18 |
20140272949 | Methods for Fully Segregating Recombinant Marine Cyanobacteria - Methods and compositions are provided for the full segregation of recombinant marine cyanobacteria. | 2014-09-18 |
20140272950 | METHOD AND SYSTEM TO PREDICT SSRI RESPONSE - The present inventions relates to methods and assays to predict the response of an individual to an SSRI treatment and to a method to improve medical treatment of a disorder, which is responsive to treatment with a selective serotonin reuptake inhibitor (SSRI). | 2014-09-18 |
20140272951 | METHODS OF IDENTIFYING MUTATIONS IN NUCLEIC ACID - The present invention provides methods of identifying mutations in nucleic acid. Also provided herein are methods of identifying subjects having Hirschsprung disease risk and diagnostic markers for Hirschsprung disease. | 2014-09-18 |
20140272952 | MULTI-PRIMER AMPLIFICATION METHOD FOR BARCODING OF TARGET NUCLEIC ACIDS - In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines. | 2014-09-18 |
20140272953 | EGFR Mutation Blood Testing - Improved methods of assessing status of a solid tumor cancer in a subject involving detection of tumor-associated mutations in the subject's blood. | 2014-09-18 |
20140272954 | METHODS AND SYSTEMS FOR ELECTRONIC KARYOTYPING - Embodiments of the present invention relate to a method for producing patterns of sequence specific markers on a chromosomal segment. By comparing these patterns to those produced on a reference chromosome, various genetic abnormalities can be detected. | 2014-09-18 |
20140272955 | NUCLEIC ACID TARGET IDENTIFICATION BY STRUCUTRE BASED PROBE CLEAVAGE - The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying cleavage fragments from probes, bound to target nucleic acids, are produced during PCR by the 5′-nuclease activity of the polymerase. The identity of the targets can be determined by identifying the unique cleavage fragments. | 2014-09-18 |
20140272956 | METHOD FOR AMPLIFICATION AND ASSAY OF RNA FUSION GENE VARIANTS, METHOD OF DISTINGUISHING SAME AND RELATED PRIMERS, PROBES, AND KITS - Method for amplification, alone or in further combination with detection or detection and quantitation, of RNA from fusion gene variants, method of distinguishing same, and oligonucleotide primers and probes and kits for use in the methods. | 2014-09-18 |
20140272957 | METHODS AND KITS FOR DIAGNOSING, PROGNOSTICATING RISK/OUTCOME, AND/OR TREATING BREAST CANCER - Methods and kits for diagnosing, prognosticating risk of, and selecting and/or administering a therapy for breast cancer based upon detection of methylated glucocorticoid receptor gene or measurement of glucocorticoid receptor and BRCA1 gene expression levels are provided. | 2014-09-18 |
20140272958 | NANOFLUIDIC DEVICES FOR THE RAPID MAPPING OF WHOLE GENOMES AND RELATED SYSTEMS AND METHODS OF ANALYSIS - Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule. | 2014-09-18 |
20140272959 | Methods of Hybridizing Probes to Genomic DNA - The present invention relates to methods of hybridizing nucleic acid probes to genomic DNA. | 2014-09-18 |
20140272960 | Methods of Identifying Homologous Genes Using FISH - The present invention relates to methods of hybridizing nucleic acid probes to genomic DNA. | 2014-09-18 |
20140272961 | METHODS AND COMPOSITIONS FOR DETECTING MUTATIONS IN THE HUMAN PI3KCA (PIK3CA) GENE - The invention comprises reagents and methods for detecting cancer-associated mutations in the human PI3KCA (PIK3CA) gene and assessing the patients based thereon. | 2014-09-18 |
20140272962 | MATERIALS AND METHODS FOR ASSESSMENT OF COLORECTAL ADENOMA - Methods of assessing colorectal adenoma, probes, and a kit. | 2014-09-18 |
20140272963 | CELL PREPARATIONS AND CELL SUPPORTS AND THEIR USE IN THERANOSIS - A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support. | 2014-09-18 |
20140272964 | Blue Fluorescent Protein and Methods of Use Thereof - This invention provides methods of making and using a fluorescent probe from the Sandercyanin protein as set forth in SEQ ID NO: 1 or SEQ ID NO: 2. In one embodiment, the invention provides a method of creating a fluorescent probe, comprising the steps of attaching a Sandercyanin moiety to a probe, wherein the probe is specific to a desired target. | 2014-09-18 |
20140272965 | SYSTEM AND METHOD FOR CAPTURING AND ANALYZING CELLS - A system and method for capturing and analyzing cells comprising: a fluid delivery module; a reservoir configured to receive a biological sample including a target cell population and at least one fluid from the fluid delivery module; a manifold configured to receive and distribute the biological sample and at least one fluid from the reservoir into a cell capture device; a waste chamber configured to couple to the manifold; and a pump configured to couple to the waste chamber. In embodiments of the system configured to promote further purification of captured cells, the system can further comprise a magnet that enables further separation of captured cells from undesired sample materials. The system can additionally further comprise a heater configured to heat at least one fluid and/or biological sample, and a cell capture device configured to couple to the manifold, in order to facilitate capture of the target cell population. | 2014-09-18 |
20140272966 | METHODS OF DIAGNOSING INCREASED RISK OF DEVELOPING MRSA - A method for diagnosing increased risk of developing Methicillin-resistant | 2014-09-18 |
20140272967 | SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS - The present disclosure relates to systems and methods for nucleic acid isolation. In particular, the present disclosure provides systems and methods for isolating low molecular weight circulating nucleic acids from bodily fluids (e.g., plasma). | 2014-09-18 |
20140272968 | SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS - The present disclosure relates to systems and methods for nucleic acid isolation. In particular, the present disclosure provides systems and methods for isolating low molecular weight circulating nucleic acids from bodily fluids (e.g., plasma). | 2014-09-18 |
20140272969 | CELL PREPARATIONS AND CELL SUPPORTS AND THEIR USE IN THERANOSIS - A method of preparing cells from a patient specimen comprising a tissue or a clump of cells; a method of in situ hybridization (ISH) or immunohistochemistry (IHC); a method of theranosing a patient's response to an active agent that targets the tyrosine kinase pathway; an improvement of a method of theranosis comprising the method of ISH or IHC; a cell support on the surface of which are cells, which have been contacted with detectably labeled probes with the method of ISH or IHC; and a kit comprising (a) a cell support and/or at least one probe for ISH or IHC, and (b) instructions for carrying out the method of ISH or IHC on a cell support. | 2014-09-18 |
20140272970 | METHOD FOR QUANTIFYING 5-HYDROXYMETHYLCYTOSINE - Provided herein are methods for detecting and quantifying 5-hydroxymethylated cytosine bases in a DNA molecule. | 2014-09-18 |
20140272971 | UNHEATED EXTRACTION OF GENOMIC DNA IN AN AUTOMATED LABORATORY SYSTEM - A method for analyzing genomic DNA includes introducing a plurality of samples comprising human cells into individual vessels in each of a plurality of multi-vessel well plates. At least a subset of the human cells in the plurality of samples is lysed without the use of heat. DNA in the at least a subset of lysed human cells is isolated with the use of a plurality of paramagnetic beads. The isolated DNA is analyzed to identify one or more single nucleotide polymorphisms (SNPs), wherein the lysing, isolating, and analyzing steps are performed substantially in parallel for each of the plurality of samples. | 2014-09-18 |
20140272972 | ENHANCED DNA SENSING VIA CATALYTIC AGGREGATION OF GOLD NANOPARTICLES BY DNA HYBRIDIZATION CHAIN REACTION - The present invention provides compositions and methods for colorimetric detection schemes for detecting a variety of biomolecules. The compositions and methods employ DNA hybridization chain reaction for catalytic aggregation of gold nanoparticles. In this catalytic aggregation scheme, a single target DNA strand triggers the formation of multiple inter-particle linkages in contrast to the single linkage formed in conventional direct aggregation schemes. | 2014-09-18 |
20140272973 | Nucleic Acid-Based Authentication and Identification Codes - The present disclosure relates to nucleic-acid based product authentication and identification by determining authentication codes comprising target nucleic acids using oligonucleotide probes associated with samples. The presence of the authentication code is determined using detection methods, such as flow cytometric methods, capable of particle discrimination based on the light scattering or fluorescence properties of the particle. Target-correlated fluorescence signal, originating from a target nucleic acid hybridized to labeled complementary oligonucleotides is determined as an indicator of the presence of the authentication code. In some embodiments, an intercalating dye is used to determine the presence of target nucleotide/oligonucleotide heterodimers and identify an authentication code. | 2014-09-18 |
20140272974 | NOVEL RETROELEMENT FOUND IN MOLLUSKS - This invention relates to a novel retroelement, named “Steamer”, found in mollusks, more specifically | 2014-09-18 |
20140272975 | DIAGNOSTIC METHOD - The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising:
| 2014-09-18 |
20140272976 | METHODS OF SCREENING FOR BINDING INTERACTION USING SETS OF MICROPARTICLES AND UNIQUE PROBES - The present invention relates to methods for screening for binding interactions using multiple sets of microparticles, wherein said set has the same identifiable characteristic and wherein one of more sets comprise subsets of microparticles and said subset presents at least one unique probe that acts as a binding partner for a target molecule in a biological sample. In particular, the invention provides for methods of detecting tissue-typing antigens in donor tissue or recipient tissue using these multiple sets of microparticles. | 2014-09-18 |
20140272977 | MOLECULAR TARGETS AND METHODS FOR FORMULATION SCREENING AND PRESERVATIVE EFFICACY TESTING - Methods and kits are disclosed for distinguishing viable from nonviable microbial cells. The methods and kits are useful in the screening of cell culture formulations and the testing of preservative efficacy. The methods involve the amplification and quantitation of microbe-specific DNA from precursor rRNA or Elongation Factor 3 mRNA in treated versus nontreated test samples using the reverse transcription polymerase chain reaction. | 2014-09-18 |
20140272978 | Method for detecting variation of gene for non-diagnostic purpose based on fluorescence quenching and probe thereof - A method for detecting variation of gene based on fluorescence quenching quantification comprises: performing single base extension at a specific site of a gene to be detected with marked probes and marked dideoxyribonucleotide triphosphate; detecting fluorescence quenching values, and determining SNP of the gene to be detected. The present invention also provides an oligonucleotide probe for the method. | 2014-09-18 |
20140272979 | FETAL CHROMOSOMAL ANEUPLOIDY DIAGNOSIS - The invention relates to prenatal detection methods using non-invasive techniques. In particular, it relates to prenatal diagnosis of a fetal chromosomal aneuploidy by detecting fetal and maternal nucleic acids in a maternal biological sample. More particularly, the invention applies multiplex PCR to amplify selected fractions of the respective chromosomes of maternal and fetal chromosomes. Respective amounts of suspected aneuploid chromosomal regions and reference chromosomes are determined from massive sequencing analysis followed by a statistical analysis to detect a particular aneuploidy. | 2014-09-18 |
20140272980 | SYSTEMS AND METHODS TO CONTROL DISSOLVED GAS - A method of sensing nucleotide reactions includes flowing at least one nucleotide solution from a container of at least two containers of a sensor system. The sensor system includes a sensor sensitive to a byproduct of nucleotide incorporation. Each container of the at least two containers includes a different nucleotide solution. The sensor system enters an idle mode after flowing. The method further includes cycling the at least two containers through at least two cycles. Each cycle includes depressurizing the at least two containers for a first period and pressurizing the at least two containers for a second period. The method also includes pressurizing the at least two containers when the sensor system enters an active mode. | 2014-09-18 |
20140272981 | MICROFLUIDIC DEVICE - Microfluidic devices of the present disclosure relate to quick and inexpensive microfluidic manipulation/handling. A number of channels may be provided for supply of fluid ingredients to a number of cavities. A separating material may provide fluid separation between a number of cavities, such as corresponding cavities of a reaction chamber. Once the cavities are supplied with fluid ingredient, channels connecting the cavities may be sealed off; that is, the cavities may be subject to fluid isolation. In some embodiments, a sealing material may be compressed so as to deform into the channels obstructing fluid flow. The separating material may be manipulated so that the initial fluid separation between cavities is removed. Removal of this fluid separation subsequently permits mixing of fluid ingredient(s) contained within previously separated cavities. In some embodiments, the fluid separation may be removed by heating or dissolving portions of the separating material. When appropriate, contents within reaction chambers may be subject to further processing (e.g., thermal cycling, various analyses). | 2014-09-18 |
20140272982 | MICROFLUIDIC DEVICE - Microfluidic devices of the present disclosure relate to quick and inexpensive microfluidic manipulation/handling. A number of channels may be supplied with fluid ingredient(s). In some embodiments, a number of protrusions as well as a sealing material may be disposed adjacent to the channels. When the channels are supplied with fluid ingredient(s), the channels may be partitioned into a number of separate cavities that are fluidly isolated from one another. For instance, a sealing material may be compressed so as to deform into the channels, obstructing fluid flow. In some embodiments, the channels supply fluid ingredients to a number of pre-formed cavities. Once the cavities are supplied with fluid ingredient, channels connecting the cavities may be sealed off; that is, the cavities may be subject to fluid isolation. When appropriate, contents within reaction chambers may be subject to further processing (e.g., thermal cycling, various analyses). | 2014-09-18 |
20140272983 | SOLID MATRIX FOR THE STORAGE OF BIOLOGICAL SAMPLES - The present invention relates to a method for storage and subsequent lysis of a sample in which the sample is immobilized on a solid support. The solid matrix is embedded with a low concentration of both a chaotropic salt and a surfactant which act synergistically to efficiently store and lyse a biological sample. | 2014-09-18 |