38th week of 2008 patent applcation highlights part 44 |
Patent application number | Title | Published |
20080227071 | Method and device to encourage children to brush their teeth - A doll or other object used to remind and encourage children to brush their teeth. This could include adjustable time setting to operate at certain times of the day, physical movement of a brush over the doll's teeth, vocal reminders and encouragement to brush the teeth or movement sensor. Operation could be mechanical or electronic or a combination of the two. | 2008-09-18 |
20080227072 | Practice model - A practice model for holding training teeth on which dentistry work can be performed includes a shell into which training teeth are insertable, and a carrier plate disposed in the shell and adapted to support the training teeth. | 2008-09-18 |
20080227073 | Methods and Apparatus for Autonomous Casualty Simulation - Method and apparatus to provide simulation of a human casualty. In one embodiment an autonomous casualty simulator includes a processing module having a scenario progression controller and a physiological modeling system to receive sensor input and to control effectors. The autonomous casualty simulator can be contained in a nominal human mannequin form. | 2008-09-18 |
20080227074 | CORRELATED ELECTRONIC NOTEBOOK AND METHOD OF DOING THE SAME - An electronic notebook, method, and computer program product for providing an electronic book accessible by a user using a computing device, and providing an electronic notebook for storing at least one user generated entry. The at least one user generated entry is correlated with at least a portion of the electronic book. | 2008-09-18 |
20080227075 | METHOD AND SYSTEM FOR REDUNDANT DATA CAPTURE FROM SCANNED DOCUMENTS - Embodiments of the invention may be used to capture student markings on assessment documents. Embodiments of the invention may be used for selected response questions or constructed response questions. Embodiments of the invention may be particularly suited to process exceptional marks. | 2008-09-18 |
20080227076 | PROGRESS MONITOR AND METHOD OF DOING THE SAME - A method, computer program product, and device for monitoring student progress may include providing a lesson selection menu for a user to select a lesson and providing a quantity selection menu for the user to select a quantity of lesson material to be rendered. The selected quantity of the selected lesson may be rendered on a computing device. A user input may be received indicating user progress toward completion of the rendered quantity of the selected lesson. Additionally, the user progress toward completion of the rendered quantity of the selected lesson may be communicated to at least one third party. | 2008-09-18 |
20080227077 | GEOGRAPHIC INFORMATION SYSTEM PROVIDING ACADEMIC PERFORMANCE INDICATORS AND RELATED METHODS - A geographic information system providing academic performance indicators may include a geographic information processing method including the steps of providing past academic performance data for at least one student residing in at least one geographic location having a lifestyle segmentation profile (LSP) associated therewith, and generating an academic performance indicator for the at least one geographic location based upon the past academic performance data and the LSP. The invention also provides a geographic information processing system having a database for storing past academic performance data for at least one student residing in at least one geographic location having an LSP associated therewith, and a processor cooperating with the database for generating an academic performance indicator for the geographic location based upon the past academic performance data and the LSP. | 2008-09-18 |
20080227078 | Weighted rating process for rating a changing, subjective category - An invention used to solve the problem in rating a changing, subjective category, like a person's subjective evaluation of their experiences dating someone, tempered by the changing state of their emotions as they deal with the breakup. | 2008-09-18 |
20080227079 | Method, Apparatus and Computer Program Code for Automation of Assessment Using Rubrics - A method and apparatus is provided for facilitating the assessment of entities including persons, standards, and/or environments. Contextual information, such as that representing the assessment by a teacher for a student, can be captured by a portable ingestion device and recorded onto media for processing and mapping into rubrics. Assessments can be optionally processed for further analysis. | 2008-09-18 |
20080227080 | STUDENT ASSESSMENT SYSTEM - Input and storage devices, student assessment systems, and methods of administering an examination are disclosed herein. An input and storage device according to one embodiment includes at least one processor, provisions for inputting answer data to the processor, and computer memory coupled to the processor. Recorded within the computer memory are machine readable instructions for: storing the answer data previously input to the processor; providing the stored answer data to a reader device; storing unique identifier data that corresponds to a user; and providing the stored unique identifier data to a reader device. The instructions for providing the stored unique identifier data to a reader device may be utilized independently of the instructions for providing the stored answer data to a reader device. | 2008-09-18 |
20080227081 | PROCESS FOR DECOMPOSING HYDROGEN SULFIDE BY MEANS OF FEEDING OXYGEN - A process is provided for decomposing hydrogen sulfide in a biogas fermenter ( | 2008-09-18 |
20080227082 | METHOD OF IDENTIFYING A MHC CLASS I RESTRICTED T CELL RESPONSE - Described are peptides and polypeptides derived from the MUC-1 polypeptide which are able to activate Cytotoxic T Lymphocyte (CTL) response, analogues of such peptides and polypeptides nucleotide sequences encoding such peptides and polypeptides and therapeutic uses thereof. Moreover, indications for selecting appropriate minimal antigenic MUC-1 polypeptides with reference to the HLA-type of the patient to be treated or tested are described. | 2008-09-18 |
20080227083 | OPTICAL DETECTOR FOR ENZYME ACTIVATION - Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first wavelength into the bodily fluid, and detects energy at second and third wavelengths emitted by the dyes in response to the energy at the first wavelength. Prior to enzymatic cleavage of the substrate, the acceptor emits energy at the third wavelength in response to energy at the second wavelength received through fluorescent resonant energy transfer (FRET) from the donor. After enzymatic cleavage of the substrate, the donor emits energy at the second wavelength. The device can determine the concentration of activated enzyme within the bodily fluid based on the relative intensities of energy, at the second and third wavelengths. | 2008-09-18 |
20080227084 | ANALYSIS OF HIV-1 CORECEPTOR USE IN THE CLINICAL CARE OF HIV-1-INFECTED PATIENTS - A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus can be shifted back to CCR5-mediated entry after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CXCR4 specific strains. The diagnostic methods can be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. | 2008-09-18 |
20080227085 | Methods and Systems for the Identification of Rna Regulatory Sequences and Compounds that Modulate their Function - The present invention is directed to a non-cell based method for identifying RNA regulatory sequences involved in translational control. The method includes: combining a translational extract; an RNA test sequence; and a reporter mRNA under suitable conditions for translation of the reporter mRNA. The method also includes measuring the effect of the test sequence on the translation of the reporter mRNA, wherein a test sequence that modifies the translation of the reporter mRNA includes an RNA regulatory element. The invention also provides methods and systems for identifying test compounds that modulate the regulatory activity of an RNA regulatory sequence. In the method, an RNA regulatory sequence, which regulates translation of a reporter mRNA, is combined with a translation extract; the reporter mRNA; and at least one test compound. The method further includes measuring the effect of the test compound on the ability of the RNA regulatory sequence to regulate the translation of the reporter mRNA. | 2008-09-18 |
20080227086 | Test System and Method for the Detection of Analytes - The invention relates to analytical test systems and analytical methods, in which molecular switches are used for the qualitative and quantitative determination of analytes in a sample, which have a broad application by means of a selection of the molecular switch suitable for the analyte. The molecular switch comprises a probe, preferably a nucleic acid or a nucleic acid derivative, coupled to a catalytic component, preferably an enzyme. The analyte induces a conformation change in the probe, which alters the accessibility for a substrate in the probe to catalytic components and the change in substrate turnover, corresponding to the change in catalytic activity, is measured. | 2008-09-18 |
20080227087 | Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx - Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant | 2008-09-18 |
20080227088 | Approaches to Identify Less Harmful Tobacco and Tobacco Products - Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained from tobacco or tobacco products induces double stranded breaks in cellular DNA, which were efficiently detected using assays that measure the presence, absence, or amount of phosphorylation of the histone, H2AX. | 2008-09-18 |
20080227089 | Method of Diagnosing and/or Predicting the Development of an Allergic Disorder - The present invention relates to methods for diagnosing an allergic disorder, predicting the development of an allergic disorder in an animal, monitoring the progress of therapy targeted at an allergic disorder, classification of the allergic disorder into one or more clinical/immunological phenotypes, and/or determining the potentional responsiveness of individual animals suffering from or at risk of an allergic disorder to particular forms of therapy. In particular, the present invention relates to a method of diagnosing and/or predicting the development of an allergic disorder in an animal, comprising the step of analysing a biological sample from the animal to determine the level of activation of one or more allergy-associated genes, in which the level of activation is diagnostic of the allergic disorder or predicative of the relative risk for the development of an allergic disorder in the animal. | 2008-09-18 |
20080227090 | METHODS, APPARATUS, AND COMPUTER PROGRAMS FOR VERIFYING THE INTEGRITY OF A PROBE - The present invention provides methods, apparatuses and computer programs for verifying the integrity of a probe by comparing the fluorescence value of a probe to a threshold value. The invention also provides for methods, apparatuses and computer programs for normalizing the fluorescence value of a probe and detecting a target nucleic acid in a sample. | 2008-09-18 |
20080227091 | QTL controlling Sclerotinia stem ROT resistance in soybean - Markers associated with | 2008-09-18 |
20080227092 | Solid-Phase Oligosaccharide Tagging: a Technique for Manipulation of Immobilized Carbohydrates - The invention relates to methods of manipulating immobilised carbohydrates by derivatisation. Depending on the nature of the derivatisation, the carbohydrate may thereby be more easily detected and/or identified or handled. In particular, the invention relates to methods of preparing a reactive sugar comprising the steps of: i) providing a sample comprising a reducing sugar; ii) providing a solid support covalently attached to a linker comprising a capture group comprising an —NH2 group, wherein said linker optionally is attached to said solid support via a spacer; iii) reacting said reducing sugar with said —NH2 group, thereby obtaining an immobilised sugar; iv) reacting free —NH2 groups with a capping agent, wherein the capping agent comprises a reactive group capable of reacting with an —NH2 group; and v) reducing C═N bonds with a reducing agent, thereby obtaining an reactive sugar of the structure SugarCH | 2008-09-18 |
20080227093 | PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR - The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor. | 2008-09-18 |
20080227094 | METHOD OF JUDGING LYMPH NODE METASTASIS OF STOMACH CANCER - Methods of judging the lymph node metastasis of stomach cancer, apparatuses for judging the lymph node metastasis of stomach cancer and kits used therefor are disclosed. | 2008-09-18 |
20080227095 | Systems and methods of analyzing nucleic acid polymers and related components - Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed. | 2008-09-18 |
20080227096 | Assay for response to proteasome inhibitors - The invention relates to a method for predicting a response to a proteasome inhibitor in the prophylaxis or treatment of a cancer in an individual. The method comprises providing a sample of cancer cells of the cancer from the individual, and evaluating the level of at least one molecule in the cancer cells associated with the unfolded protein response of the cancer cells, to provide test data indicative of the level of activity of the unfolded protein response. The test data is used to predict the response of the cancer cells to the proteasome inhibitor. The evaluation of the level of the molecule can be utilized for determination of treatment for the cancer. | 2008-09-18 |
20080227097 | FLUORESCENT PROTEIN AND CHROMOPROTEIN - It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from | 2008-09-18 |
20080227098 | METHOD FOR DIAGNOSING CANCER OF THE PROSTATE - Methods for diagnosis and prognosis of prostate cancer are provided. The methods involve the detection of the level of expression of Claudin-1 in tissue or cell samples. Claudin-1 is underexpressed or non-expressed in the majority of prostate cancers. | 2008-09-18 |
20080227099 | COMPOSITIONS AND METHODS FOR INCREASING CHOLESTEROL EFFLUX AND RAISING HDL USING ATP BINDING CASSETTE TRANSPORTER PROTEIN ABC1 - The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising ABC1 polynucleotides, as well as to methods for producing ABC1 polypeptides. The invention also relates to antibodies that bind specifically to ABC1 polypeptides. In addition, the invention relates to methods for increasing cholesterol efflux as well as to methods for increasing ABC1 expression and activity. The present invention further relates to methods for identifying compounds that modulate the expression of ABC1 and methods for detecting the comparative level of ABC1 polypeptides and polynucleotides in a mammalian subject. The present invention also provides kits and compositions suitable for screening compounds to determine the ABC1 expression modulating activity of the compound, as well as kits and compositions suitable to determine whether a compound modulates ABC1-dependent cholesterol efflux. | 2008-09-18 |
20080227100 | METHOD FOR ESTIMATING hERG INHIBITION OF DRUG CANDIDATES USING MULTIVARIATE PROPERTY AND PHARMACOPHORE SAR - The present invention provides a computational model and methods of use thereof for predicting whether a compound is likely to inhibit K | 2008-09-18 |
20080227101 | METHODS FOR TESTING MILK - The disclosure is related generally to methods for testing mammary fluid (including milk) to establish or confirm the identity of the donor of the mammary fluid. Such methods are useful in the milk-bank business to improve safety. | 2008-09-18 |
20080227102 | Methods for Identification of Merle Gene - Animals with mutations in SILV present with the merle coat color pattern phenotype. Methods for the identification of animals that harbor a mutation in the SILV gene are described. Mutations in the SILV gene can be identified from any biological sample such as a cell or tissue that contains genomic DNA. A microsatellite marker identified using linkage disequilibrium mapping that segregates with merle is also described. | 2008-09-18 |
20080227103 | Method for identification of polynucleotides capable of cleaving target mRNA sequences - Provided are methods for identifying a polynucleotide that can reduce the level of a target mRNA. The method can be performed by providing cells that express an RNA polynucleotide that contains a target mRNA sequence, an internal ribosome entry sequence (IRES) and a sequence encoding a secreted reporter protein; introducing to the cells a test polynucleotide, and measuring activity of the secreted reporter protein. A reduction in secreted reporter protein activity relative to a control cell into which the test polynucleotide has not been introduced is indicative that the test polynucleotide is capable of reducing the level of the target mRNA in the cells. The method is adaptable for high throughput screening methods and is suited for identifying polynucleotides that can catalyze cleavage of target mRNA and/or act on target mRNA through and antisense or RNAi mechanism. | 2008-09-18 |
20080227104 | Primer, primer set, and nucleic acid amplification method and mutation detection method using the same - The present invention provides a primer that effectively can detect, for example, the double helix structure of a nucleic acid. The primer is a labeled nucleic acid containing at least one structure represented by the following formula (16), | 2008-09-18 |
20080227105 | Method for diagnosing diseases - An improved method for diagnosing autoimmune or genetic diseases is provided in this disclosure. In particular, a method to diagnose diseases affecting the tissues of organs selected from the group of spleen, brain, heart, kidney, thyroid, eye, skin, intestine, liver, pancreas, adrenal gland, prostate and lungs or from the tissues selected from the group of muscles and bones or other tissues. More specifically, the present invention provides an improved method for diagnosing diseases affecting neuromuscular junctions. | 2008-09-18 |
20080227106 | Compositions and methods for the diagnosis and treatment of tumor - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2008-09-18 |
20080227107 | COMPOSITIONS AND METHODS FOR LABELING OF NUCLEIC ACID MOLECULES - The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic acid molecules produced in accordance with the invention are particularly suited as labeled probes for nucleic acid detection and diagnostics. | 2008-09-18 |
20080227108 | MOLECULAR IDENTIFICATION OF ASPERGILLUS SPECIES - Novel techniques for the detection of | 2008-09-18 |
20080227109 | Risk assessment for adverse drug reactions - The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS/TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB 1 and HLA-A region of the specific HLA-B haplotype can also be used for the test. | 2008-09-18 |
20080227110 | Human Genes, Sequences and Expression Products - Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides. | 2008-09-18 |
20080227111 | REAGENT KIT AND METHOD FOR MEASURING HCV ANTIBODY - A reagent kit for measuring an HCV antibody is described herein. This reagent comprises a first and second reagents. The first reagent comprises an HCV synthetic peptide antigen which has a solid phase binding site. The second reagent comprises a solid phase. On the solid phase is immobilized a binding substance and/or an HCV recombinant HCV antigen. The binding substance can bind to the solid phase binding site. | 2008-09-18 |
20080227112 | Global polyclonal antibodies, process for depleting commonly shared proteins by same, devices using same - A method for removing abundance proteins from a biological sample comprises passing the biological sample through a support. The support is coated with an avian polyclonal antibody. The avian polyclonal antibody is capable of binding to substantially all proteins in the biological sample with concentrations higher than a predetermined value. The method for removing abundance proteins from a biological sample further comprises collecting the pass-through fractions of the biological sample. | 2008-09-18 |
20080227113 | Methods, Antibodies and Kits for Detecting Cerebrospinal Fluid in a Sample - The present disclosure relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample, in particular to the analysis of the CSF protein lipocalin-type prostaglandin D2 synthase (L-PGDS). The present disclosure provides assays for the analysis of L-PGDS indicating the presence or absence of CSF in a sample. | 2008-09-18 |
20080227114 | COMPOSITIONS AND METHODS FOR MODULATING C-REL-DEPENDENT CYTOKINE PRODUCTION - The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NFκB and/or the amount of IκB. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of c-Rel but where the level of expression of NFκB and/or the amount of IκB is materially unaltered. | 2008-09-18 |
20080227115 | Inhibition of cancer metastasis - The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-α (IKKα) and the IKKα-mediated suppression of Maspin expression observed in metastatic prostate cancer cells. | 2008-09-18 |
20080227116 | Histaminase Determination - Disclosed is a method for determining histaminase (DAO; EC 1.4.3.6) activity in a sample. Said method comprises the following steps: an aqueous solution is supplied which contains a predefined amount of a diamine; the aqueous solution is mixed and incubated with the sample for a given period of time in conditions in which the diamine can be reacted with a DAO possibly present in the sample; the diamine is derivatized; the amount of derivatized diamine is determined; the predefined amount of diamine is compared to the amount of derivatized diamine; and the activity of histaminase possibly present is determined. | 2008-09-18 |
20080227117 | Peptides as Biomarkers of Copd - The present invention relates to the identification of biomarkers for the disease condition COPD. The uses of such biomarkers in diagnosis and therapy and a novel method for their identification is are also described. | 2008-09-18 |
20080227118 | Protein Immobilization Method and Quantification Method - The present invention relates to a method for immobilizing a protein in a sample, which could not easily be immobilized by the conventional immobilization method, to a solid-phase; a method for quantitative determination of protein wherein an effect of inhibitory substance coexisting in a sample prepared using the immobilization method can be reduced; and a rapid and highly precise method for detecting an abnormal PrP and a method for determining BSE using the immobilization method as compared with the conventional method. The present invention provides: “a method for immobilizing a protein to a solid-phase comprising contacting the protein with the solid-phase having hydrophobic surface in the presence of a lower alcohol, and a halogenocarboxylic acid and/or a long chain alkyl sulfate, and an immobilizing reagent solution to be used therefor; a method for quantitative determination of protein comprising contacting a protein-staining solution with the solid-phase immobilized with a protein by the immobilization method, and determining a degree of color development generated thereby; an immunoblotting method wherein the solid-phase immobilized with a protein by the immobilization method is used; and a method for detecting an abnormal PrP a method for determining BSE by using the immobilization method.” | 2008-09-18 |
20080227119 | ELISA for VEGF - The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in biological samples from animal models and human patients and can be used as a diagnostic/prognostic index. | 2008-09-18 |
20080227120 | FRET-BASED ASSAY FOR SCREENING MODULATORS OF RECEPTOR CYCLING - Automated FRET imaging of membrane-bound receptor/ligand complexes can discriminate between a clustered organization of ligand/receptor complexes that occurs during the early endocytic stages following internalization and a random distribution characteristic of late stage disassociation of ligand from the receptor. In the case of the low density lipoprotein receptor (LDL-R) and its ligand, LDL, this feature of FRET imaging forms the basis of an assay to monitor the endosomal release of cholesterol into the cell and identify compounds which alter pH in the endosome thereby inhibiting the disassociation of ligand and cholesterol from the receptor, a mechanism that is involved in regulation of plasma/serum cholesterol. | 2008-09-18 |
20080227121 | Inducible ligand for alpha1beta1 integrin and uses - The present invention is directed to the identification and use of agents, particularly peptides and monoclonal antibodies that disrupt the interaction between Collagen XIII and α1β1 integrin. | 2008-09-18 |
20080227122 | P2Y PURINERGIC RECEPTOR EXPRESSION FOR IDENTIFYING PRENEOPLASTIC AND NEOPLASTIC STATES - The present invention relates to methods for identifying pre-neoplastic and neoplastic states in mammals and in particular to a method for identifying pre-neoplasia and neoplasia in cells and tissues based on differential expression of P2Y purineric receptors. | 2008-09-18 |
20080227123 | Methods for Specifically Selecting Antibody-Producing Cells - Methods are provided for selecting B cells that produce a desired antibody, comprising a step of culturing B cells, which have the properties of cell death being induced under specific conditions and that cell death being suppressed by a signal generated as a result of the binding between an antigen and an antibody expressed on B cell surface (B cell antigen receptor on the B cell surface), with an antigen under conditions in which cell death is induced, and selecting antibody-producing B cells that bind with the antigen as viable cells. | 2008-09-18 |
20080227124 | Solid phases optimized for chemiluminescent detection - Solid supports for chemiluminescent assays are provided. The solid support includes a plurality of probes covalently or physically attached to the support surface and a chemiluminescent enhancing moiety incorporated onto the surface or into the bulk of the support. The solid support can be a multi-layered support including an upper probe binding layer (e.g., an azlactone polymer layer or porous functional polyamide layer) adjacent to a cationic microgel layer. The azlactone-functional polymer can be a copolymer of dimethylacrylamide and vinylazlactone crosslinked with ethylenediamine. The cationic microgel layer can be a cross-linked quaternary onium salt containing polymer. A method and a kit for conducting chemiluminescent assays using the solid supports is also provided. The kit comprises a dioxetane substrate, a biopolymer probe-enzyme complex, and a solid support. The solid support can be an azlactone functional polymer layer adjacent to a cationic microgel layer; a porous polyamide functional layer adjacent to a cationic microgel layer; or a quaternized azlactone functional polymer layer. | 2008-09-18 |
20080227125 | Secreted Polypeptide Species Reduced in Cardiovascular Disorders - The invention discloses human secreted polypeptides that circulate at a decreased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and for drug development. | 2008-09-18 |
20080227126 | OPTICAL WAVEGUIDE TYPE ANTIBODY CHIP AND METHOD OF MEASURING ANTIGEN CONCENTRATION - An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide layer formed between the optical elements, the water repellent resin film includes a reaction hole having exposed the optical waveguide layer on its bottom and a frame-shaped trench surrounding the reaction hole, a rectangular frame-shaped cell wall which is fixed in the trench of the water repellent resin film and which forms a cell capable of infusion and discharge of a specimen solution together with the reaction hole, and an antibody immobilization layer formed on the bottom of the reaction hole, the surface of the antibody immobilization layer being masked with at least a buffer agent and a salt. | 2008-09-18 |
20080227127 | Human NK3-Related Prostate Specific Gene-1 - The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers. | 2008-09-18 |
20080227128 | Resonance Energy Transfer System and Method - The present invention relates to a novel BRET system. The BRET system can be used to identify modified recognition sites within a protein insert and to identify the compounds involved in modulation of a given modification. The BRET system of the present invention can also be used in a screening method construct insert to identify candidates for drug development. | 2008-09-18 |
20080227129 | Methods of protein destabilization and uses thereof - This invention is directed towards methods of destabilizing proteins in living cells, and their use for the development of novel assays. In one embodiment, the invention comprises the use of non-cleavable multimerized ubiquitin fusion proteins to destabilize a target protein, such as a reporter moiety. In one aspect of this method the constructs also comprises a linker that operatively couples the reporter moiety to the multimerized ubiquitin fusion protein. In this embodiment, enzymatic modification of the linker results in a modulation of the coupling of the reporter protein to the multimerized ubiquitin domains resulting in a change in the stability of the reporter moiety. The level of the reporter moiety in the cell can then be used as a measure of the enzymatic activity in the cell. In another embodiment the invention provides for a generalized way of coordinately regulating the cellular concentration of a plurality of target proteins. In one aspect of this method, the target proteins are operatively coupled to a ubiquitin fusion protein via a linker containing a protease cleavage site. Cleavage of the linker by a protease results in uncoupling of the target protein from the multimerized ubiquitin construct, and results in an increase in the stability and concentration of the target protein. | 2008-09-18 |
20080227130 | Method for detecting exposure to ionizing radiation - A method for detecting exposure to ionizing radiation. An HbA1c test is performed on blood extracted from an animal at a first time, to establish a baseline glycosylated hemoglobin score, and a second HbA1c test is performed on blood extracted from the animal at a second time, to establish a test glycosylated hemoglobin score. The test and baseline scores are compared to determine any difference, and an inference is drawn as to whether the animal has or has not been exposed to ionizing radiation between the first and second times based, at least in part, on the amount of the difference. | 2008-09-18 |
20080227131 | Signalling Assay and Cell Line - The invention relates to a sensor for indicating the transduction and inhibition of stress signals through the p38-MAPK pathway in living cells. The sensor comprises a reporter gene product and an isoform of p38 Mitogen Activated Protein Kinase (MAPK). The invention also provides plasmid and viral vectors containing nucleic acids encoding the sensor for the transfection of living cells. Stable cell lines expressing the sensor can be used in a live-cell or fixed-cell assay to measure activation or modulation of the pathway. | 2008-09-18 |
20080227132 | Hydrolase Enzymes and Their Use in Kinetic Resolution - The invention relates to hydrolases and to polypeptides having hydrolase activity. In addition, the invention relates to the use of these hydrolase enzymes in kinetic resolution. | 2008-09-18 |
20080227133 | KpnI Restriction Endonucleases with Reduced Star Activity - Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of modifications to restriction endonucleases with significant sequence identity with KpnI are provided and reduced star activity demonstrated. | 2008-09-18 |
20080227134 | Glyoxylate assays and their use of inden tifying natural amidated compounds - Methods for detecting and assaying for glyoxylate, include enzyme-based assays and/or assays for hydrogen peroxide following liberation of hydrogen peroxide from glyoxylate, are disclosed. In some embodiments, the invention is directed to methods for assaying for glyoxylate produced by the reaction of peptidylglycine alpha-amidating monooxygenase (PAM). The subject invention also concerns methods for assaying for the enzyme peptidylglycine alpha-amidating monooxygenase and/or its substrates. The detection of glyoxylate is indicative of the presence of PAM and/or its substrates. The subject invention also concerns methods for screening for peptide hormones, amidated fatty acids, any N-acyl-glycine or N-aryl-glycine conjugated molecule, and generally compounds having a glycine reside in free acid form and attached to a carbonyl group. | 2008-09-18 |
20080227135 | Autoimmune Conditions and NADPH Oxidase Defects - The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing arthritis conditions that are accompanied by an NADPH oxidase deficiency, methods and materials involved in treating, preventing, or delaying the onset of arthritis conditions that are accompanied by an NADPH oxidase deficiency, and methods and materials involved in identifying agonists and antagonists of NADPH oxidase activity. | 2008-09-18 |
20080227136 | Cell culture improvements - The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture. | 2008-09-18 |
20080227137 | METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS - A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1 | 2008-09-18 |
20080227138 | Methods to Increase or Decrease Bone Density - The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis. | 2008-09-18 |
20080227139 | SYSTEM, METHOD AND APPLICATIONS INVOLVING IDENTIFICATION OF BIOLOGICAL CIRCUITS SUCH AS NEUROLOGICAL CHARACTERISTICS - Various aspects are directed to systems and methods for assessing neural activity of a neural region having multiple subfields. In certain embodiments, a method includes evoking a cellular electrical response in at least one subfield due to neural activity in the neural region, capturing image data of the electrical response at a level sufficiently detailed in space and time to differentiate between polarization-based events of two respective portions of the subfield, and then assessing neural activity by correlating space and time information, from the captured data, for the two respective portions of the sub-field. Other more specific aspects of the invention involve different preparation and neural stimulation approaches which can vary depending on the application. | 2008-09-18 |
20080227140 | TRP/HIS Exchange and Kynurenine Induced TRP Transport - The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression. | 2008-09-18 |
20080227141 | PROCESS FOR PRODUCING ISOPRENOID COMPOUNDS BY MICROORGANISMS AND A METHOD FOR SCREENING COMPOUNDS WITH ANTIBIOTIC OR WEEDING ACTIVITY - The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway. | 2008-09-18 |
20080227142 | Invasive chemometry - The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest. | 2008-09-18 |
20080227143 | STABILIZED HEMATOXYLIN - A stabilized hematoxylin composition is disclosed that includes one or both of a host compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process without undue degradation prior to use of the composition to stain a biological sample. Methods of using and making the stabilized composition also are disclosed. | 2008-09-18 |
20080227144 | Tissue sample support and orientation device - Disclosed is a tissue sample support and orientation device comprising: (i) a base member formed of one or more materials which can be sectioned in a microtome and which is resistant to histological stains and to degradation from chemicals used to fix and process tissue; and (ii) a plurality of support members arranged on the base member in a predetermined spaced relationship, each of the support members having a stem portion and a head portion and formed of one or more materials which can be sectioned in a microtome and which is resistant to histological stains and to degradation from chemicals used to fix and process tissue, wherein the stem portion has a proximal end attached to the base member and a distal end attached to the head portion, and further wherein the head portion is dimensioned to engage and retain a tissue sample during processing thereof. | 2008-09-18 |
20080227145 | Filamentous Fungal Mutants With Improved Homologous Recombination Efficiency - The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for NHR, wherein said polynucleotide has a region of homology with said pre-determined site, comprising steering an integration pathway towards HR. The present invention also relates to a mutant filamentous fungus originating from a parent cell, said mutant having an HR pathway with elevated efficiency and/or an NHR pathway with a lowered efficiency and/or a NHR/HR ratio with decreased efficiency as compared to said HR and/or NHR efficiency and/or NHR/HR ratio of said parent cell under the same conditions. | 2008-09-18 |
20080227146 | Immortalized Avian Cell Lines For Virus Production - The present invention relates to immortalized avian cell lines suitable for production of biologicals or viruses for vaccination. In particular, the cell lines are derived from primary cells which are transformed with at least two viral or cellular genes, one of which causes cell cycle progression whereas the other interferes with innate protective mechanisms of the cell induced by dysregulated replication. The invention moreover relates to the production of said immortalized cell lines and their use for producing biologicals or viruses for vaccination. | 2008-09-18 |
20080227147 | Fungal Cell Wall Degrading Enzyme - A novel fungal enzyme having lysozyme activity has been isolated. The invention further relates to a fungal polypeptide having lysozyme activity and belonging to the GH25 family, wherein the enzyme is selected from the group consisting of (a) a polypeptide comprising an amino acid sequence, which has at least 80% identity with amino acids 1 to 233 of SEQ ID NO:2; (b) a polypeptide comprising an amino acid sequence, which has at least 80% identity with the polypeptide encoded by the lysozyme encoding part of the nucleotide sequence inserted into a plasmid present in strain DSM 16084; (c) a polypeptide which is encoded by a nucleotide sequence which hybridizes under high stringency conditions with a polynucleotide probe consisting of the complementary strand of nucleotides 84 to 782 of SEQ ID NO:1; or (d) a fragment of (a), (b) or (c) that has lysozyme activity. | 2008-09-18 |
20080227148 | Aspergillus Promotors for Expressing a Gene in a Fungal Cell - The present invention relates to isolated promoter DNA sequences, to DNA constructs, vectors, and host cells comprising these promoters in operative association with coding sequences. The present invention also relates to methods for expressing a gene and/or producing a biological compound using the new promoters isolated. The present invention also relates to methods for altering the transcription level and/or regulation of an endogenous gene using the new promoter of the invention. | 2008-09-18 |
20080227149 | Interferon-Alpha Polypeptides and Conjugates - The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids. | 2008-09-18 |
20080227150 | OVEREXPRESSION OF PHYTASE GENES IN YEAST SYSTEMS - The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a heterologous phytase and the vectors used to produce the phytase are also provided. | 2008-09-18 |
20080227151 | Method for simultaneous production of multiple proteins; vectors and cells for use therein - Described is the production of proteins in a host cell. Even more specifically, described are methods for improving expression of two or more proteins in a cells or host cell. The methods are suited for production of, for example, recombinant antibodies that can be used in pharmaceutical preparations or as diagnostic tools. In certain embodiments, provided are methods for obtaining a cell that expresses two or more proteins comprising providing the cell with two or more protein expression units encoding two or more proteins, characterized in that at least two of the protein expression units comprise at least one STAR sequence. | 2008-09-18 |
20080227152 | In vivo incorporation of unnatural amino acids - The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. | 2008-09-18 |
20080227153 | Site specific incorporation of keto amino acids into proteins - Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs. | 2008-09-18 |
20080227154 | Protein Expression - Disclosed is chimeric polynucleotides adopted for providing high-yield expression and secretion of recombinant polypeptides. The chimeric polynucleotide of the invention includes a functional secretion signal peptide derived from | 2008-09-18 |
20080227155 | PEGYLATED SOLUBLE GP130-DIMERS USEFUL AS A MEDICAMENT - A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described. | 2008-09-18 |
20080227156 | NUCLEIC ACIDS ENCODING NEUTRALIZING GDF8 EPITOPE-BASED PEPTIDES AND FUSION PROTEINS - The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new peptides and/or fusion proteins, antibodies that specifically bind to the new peptides of GDF8, and methods of treating animals in order to modulate the activity of GDF8, employing vaccines or antibodies according to the invention. | 2008-09-18 |
20080227157 | Nucleic acids encoding fusion proteins based on ribosome-inactivating proteins of the mistletoe Viscum Album - The invention relates to nucleic acid molecules which encode fusion proteins which contain as components at least one effector module, a processing module and a targeting module. The nucleic acid molecules according to the invention preferably also encode a modulator module and/or an affinity module. The invention furthermore relates to vectors containing these nucleic acid molecules, hosts transformed with the vectors according to the invention, fusion proteins encoded by nucleic acids according to the invention or produced by the hosts according to the invention as well as to medicaments containing the polypeptides or vectors according to the invention. The invention thus also concerns corresponding processes, uses and kits. | 2008-09-18 |
20080227158 | NOVEL POLYPEPTIDE, NOVEL DNA AND NOVEL ANTIBODY - The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present invention, using the transformant; an antibody which recognizes the polypeptide; a ligand for the polypeptide of the present invention; a compound inhibiting specific binding between the polypeptide and ligand of the present invention; a compound enhancing the expression of an aging-suppressing gene encoding the aging-suppressing polypeptide of the present invention; an oligonucleotide comprising a sequence of 10 to 50 nucleotides in the nucleotide sequence of the DNA; and a therapeutic agent for a syndrome resembling premature aging, a therapeutic agent for adult diseases or an aging-suppressing agent, using the same. | 2008-09-18 |
20080227159 | Compositions and Methods Using Split Polymerases - The invention relates to compositions and methods utilizing split polymerase enzymes composed of at least two discrete polypeptides that stably associate to form a single polymerase. The invention further relates to nucleic acid constructs for expressing the split polymerases of the invention, and methods for using the split polymerases of the invention. The enzymes of the invention are useful in many applications calling for the detectable labeling of nucleic acids and are particularly useful in quantitative PCR (QPCR) and DNA sequencing applications. | 2008-09-18 |
20080227160 | Circular DNA vectors for synthesis of RNA and DNA - The present invention provides methods for synthesis and therapeutic use of DNA and RNA oligonucleotides and analogs. RNA oligonucleotides are synthesized using a small, circular DNA template which lacks an RNA polymerase promoter sequence. The RNA synthesis is performed by combining a circular single-stranded oligonucleotide template with an effective RNA polymerase and at least two types of ribonucleotide triphosphate to form an RNA oligonucleotide multimer comprising multiple copies of the desired RNA oligonucleotide sequence. Preferably, the RNA oligonucleotide multimer is cleaved to produce RNA oligonucleotides having well-defined ends. Preferred RNA oligonucleotide multimers contain ribozymes capable of both cis (autolytic) and trans cleavage. | 2008-09-18 |
20080227161 | METHODS FOR PRODUCING A HYDROLYSATE AND ETHANOL FROM LIGNOCELLULOSIC MATERIALS - A method for producing a hydrolysate from lignocellulosic materials generally includes fiberizing the lignocellulosic materials, separating the lignocellulosic materials into at least a first portion and a second portion, wherein at least the first portion includes lignin, treating the first portion to deactivate at least a portion of the lignin in the first portion, re-combining the first and second portions after treating the first portion, and hydrolyzing the lignocellulosic materials with enzymes to produce a hydrolysate. | 2008-09-18 |
20080227162 | Biomass pretreatment - A method for lignocellulose conversion to sugar with improvements in yield and rate of sugar production has been developed by using ionic liquid pretreatment. This new pretreatment strategy substantially improves the efficiency (in terms of yield and reaction rates) of saccharification of lignocellulosic biomass. Cellulose and hemicellulose, when hydrolyzed into their sugars, can be converted into ethanol fuel through well established fermentation technologies. These sugars also form the feedstocks for production of variety of chemicals and polymers. The complex structure of biomass requires proper pretreatment to enable efficient saccharification of cellulose and hemicellulose components to their constituent sugars. Current pretreatment approaches suffer from slow reaction rates of cellulose hydrolysis (by using the enzyme cellulase) and low yields. | 2008-09-18 |
20080227163 | Production of L-ribose and other rare sugars - The invention provides methods and compositions for the production of | 2008-09-18 |
20080227164 | Process For Producing Mycophenolic Acid Using Penicillium Arenicola Bicc 7673 - The present invention discloses the manufacture of MPA by fermentation under optimal fermentation parameters using a new strain of | 2008-09-18 |
20080227165 | Process for producing conjugated fatty acid and food/drink produced by the process - A conjugated fatty acid such as the cis-9, trans-11 isomer of conjugated linoleic acid having high bioactivities is selectively and efficiently produced by conjugating an unsaturated fatty acid having at least two double bonds with the use of viral cells, dead cells or a cell extract of at least one bacterium selected from the group consisting of | 2008-09-18 |
20080227166 | Fermentation Processes - The present invention provides an improved process for producing a fermentation product in a fermentation medium, including ethanol, which process include a fermentation step, comprising subjecting the fermentation medium to at least one surfactant and at least one carbohydrate-source generating enzyme. | 2008-09-18 |
20080227167 | PROCESS FOR IMMOBILIZED NANO-SIZED METAL PARTICLES - The present invention provides a new process using biological method for the preparation of immobilized nano-particles of metals. Fungi are used to efficiently prepare immobilized nano-particles of various metals ions such as Au, Ag, Pd, Pt, Ni, Rh and Ru from their aqueous solutions. | 2008-09-18 |
20080227168 | METHODS AND MATERIALS FOR EXTRA AND INTRACELLULAR DELIVERY OF CARBON NANOTUBES - The present invention includes compositions and methods to deliver carbon nanostructures that include agents for delivery to cells, wherein the carbon nanostructure and the agent are made soluble by coating the carbon nanostructure with one or more polymers, e.g., low band gap conductive polymers. | 2008-09-18 |
20080227169 | SURFACE-BOUND FLUORINATED ESTERS FOR AMINE CAPTURE - A method for immobilizing an amino-containing material to a substrate is described. The method involves providing a tethering compound with two reactive groups: a substrate reactive group and a fluoroalkoxycarbonyl group. The method further involves preparing a substrate-attached tethering group by reacting the substrate reactive group of the tethering compound with a complementary functional group on the surface of a substrate. The substrate-attached tethering group has a fluoroalkoxycarbonyl group that can be reacted with an amino-containing material to form an immobilization group that connects the amino-containing material to the substrate. | 2008-09-18 |
20080227170 | Use of Pit Emulsions in Biocatalytic Reactions - Oil-in-water emulsions produced by the phase inversion temperature process, with droplet sizes of 50 to 400 nm, for use as the reaction medium for biocatalytic reactions. | 2008-09-18 |