| 37th week of 2008 patent applcation highlights (09-11-08/09-11-08_39) part 39 |
| Patent application number | Title | Published |
|---|
| 20080220002 | MODIFIED TRANSFERIN-ANTIBODY FUSION PROTEINS - Modified fission proteins of transferrin and therapeutic proteins or peptides, preferably antibody variable regions, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor. | 09-11-2008 |
| 20080220003 | C5a Receptor Antagonists - The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 and R22 are individually and independently selected from the group comprising H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, alkoxyl, substituted alkoxyl, aryloxy, substituted aryloxy, arylalkyloxy, substituted arylalkyloxy, acyloxy, substituted acyloxy, halogen, hydroxyl, nitro, cyano, acyl, substituted acyl, mercapto, alkylthio, substituted alkylthio, amino, substituted amino, alkylamino, substituted alkylamino, bisalkyl amino, substituted bisalkyl amino, cyclic amino, substituted cyclic amino, carbamoyl (—CONH | 09-11-2008 |
| 20080220004 | Use of VEGF inhibitors for treatment of eye disorders - Modified chimeric polypeptides with improved pharmacokinetics and improved tissue penetration are disclosed useful for treating eye disorders, including age-related macular degeneration and diabetic retinopathy. | 09-11-2008 |
| 20080220005 | Comb Polymers - The present invention provides a process for producing a comb polymer comprising the steps of: a) providing: (i) (w+z) molar equivalents of a monomer; (ii) one molar equivalent of an initiator compound of formula (IX), wherein B | 09-11-2008 |
| 20080220006 | Method for Modulating Inflammatory Responses - The present invention is a method for inhibiting T | 09-11-2008 |
| 20080220007 | EHRLICHIA CANIS GENES AND VACCINES - This invention provides the sequence of 5,299 nucleotides from the | 09-11-2008 |
| 20080220008 | Mutated Hiv Nef For Modulating Immunity - Described is the use of a mutation of at least one amino acid in the immunosuppressive domain of a HIV or SIV accessory protein, for modulating the immunosuppressive property of the protein. | 09-11-2008 |
| 20080220009 | Rodent hepatitis B virus core proteins as vaccine platforms and methods of thereof - The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations. | 09-11-2008 |
| 20080220010 | Immunogenic Compositions for Streptococcus Agalactiae - This application relates to Group B | 09-11-2008 |
| 20080220011 | Use of Flagellin in Tumor Immunotherapy - The invention provides a fusion protein comprising a flagellin adjuvant and a tumor antigen. Also provided are compositions comprising a flagellin adjuvant and a tumor antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against a tumor antigen and methods of treating a tumor in a subject. | 09-11-2008 |
| 20080220012 | Therapeutic Compositions that alter the immune response - The invention is therapeutic methods and compositions that alter the immunogenicity of the host. | 09-11-2008 |
| 20080220013 | Diagnostic Method for Brain Damage-Related Disorders - A brain damage-related disorder is diagnosed in a subject by detecting at least one polypeptide, or a variant or mutant thereof, in a sample of body fluid taken from the subject, wherein the polypeptide is one for which the level is either increased or decreased in cerebrospinal fluid from deceased patients compared to cerebrospinal fluid from healthy donors. | 09-11-2008 |
| 20080220014 | Recombinant viral-based malaria vaccines - The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different | 09-11-2008 |
| 20080220015 | METHOD OF MODULATING NEUTRALIZING ANTIBODIES FORMATION IN MAMMALS, AND USES THEREOF IN GENE THERAPY, ANIMAL TRANGENESIS AND IN FUNCTIONAL INACTIVATION OF ENDOGENOUS PROTEINS - Disclosed is a method of modulating neutralizing antibodies formation against a heterologous protein. The method may be used to induce tolerance of the immune system towards the protein, such tolerance being useful to allow long-term gene therapy or transgene expression. The method may also be used to provide an animal with a reproducible functional inactivation phenotype of an endogenous protein of the animal. | 09-11-2008 |
| 20080220016 | Method of Treating and Preventing Infectious Diseases via Creation of a Modified Viral Particle with Immunogenic Properties - The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious organism, thereby reducing the infectivity of the infectious organism. The present invention uses optimal solvent systems such that the lipid envelope around the viral particle is dissolved while the viral particle remains intact, resulting in a modified viral particle. The present invention also provides an autologous vaccine composition, comprising a lipid-containing infectious organism, treated with solvents to reduce the lipid content of the infectious organism, combined with a pharmaceutically acceptable carrier. The vaccine composition is administered to an animal or a human to provide protection against the lipid-containing infectious organism. The present invention further provides a simple, inexpensive and easy to use kit for delipidating fluids and for delipidation of lipid-containing organisms in a fluid. | 09-11-2008 |
| 20080220017 | Method of Treating and Preventing Infectious Diseases via Creation of a Modified Viral Particle with Immunogenic Properties - The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious organism, thereby reducing the infectivity of the infectious organism. The present invention uses optimal solvent systems such that the lipid envelope around the viral particle is dissolved while the viral particle remains intact, resulting in a modified viral particle. The present invention also provides an autologous vaccine composition, comprising a lipid-containing infectious organism, treated with solvents to reduce the lipid content of the infectious organism, combined with a pharmaceutically acceptable carrier. The vaccine composition is administered to an animal or a human to provide protection against the lipid-containing infectious organism. The present invention further provides a simple, inexpensive and easy to use kit for delipidating fluids and for delipidation of lipid-containing organisms in a fluid. | 09-11-2008 |
| 20080220018 | VACCINE COMPOSITION FOR VACCINATING DOGS AGAINST CANINE INFECTIOUS RESPIRATORY DISEASE(CIRD) - A vaccine composition for vaccinating dogs comprising any one or more of (a) an agent capable of raising an immune response against | 09-11-2008 |
| 20080220019 | Nucleic Acid Construct Containing Fulllength Genome of Human Hepatitis C Virus, Recombinant Fulllength Virus Genome-Replicating Cells Having the Nucleic Acid Construct Transferred Thereinto and Method of Producing Hepatitis C Virus Particle - The present invention provides a method for replicating efficiently an RNA containing fulllength HCV genomic sequence and a method for producing HCV virus particles containing fulllength HCV replicon RNA or fulllength HCV genomic RNA by using a cell culture system. Further, the present invention relates to a method for producing hepatitis C virus particles which comprises culturing a cell, into which a replicon RNA comprising a nucleotide sequence comprising a fulllength genomic RNA sequence of hepatitis C virus of the genotype 2a, at least one selectable marker gene and/or at least one reporter gene and at least one IRES sequence or the fulllength genomic RNA of hepatitis C virus of the genotype 2a is introduced, and generating virus particles in the culture medium. Still further the present invention relates also to a hepatitis C vaccine and an antibody against hepatitis C virus particles. | 09-11-2008 |
| 20080220020 | Transdermal Botulinum Toxin Compositions - Pharmaceutical compositions for transdermal administration of neurotoxins to a patient include a neurotoxin, such as a botulinum toxin, and an enhancing agent that facilitates absorption of the neurotoxin through the skin of the patient and does not eliminate the bioactivity associated with the neurotoxin. The pharmaceutical compositions are topically applied on a patient, and may be provided in a transdermal patch. | 09-11-2008 |
| 20080220021 | Topical Botulinum Toxin Compositions for the Treatment of Hyperhidrosis - The use of a topical botulinum toxin composition is disclosed for the treatment of a disorder amenable to treatment by botulinum toxin. The disorder may comprise the symptoms associated with hyperhidrosis. The topical botulinum toxin composition comprises phospholipid micelles, one or more primary stabilizers, and one or more skin penetration enhancers. | 09-11-2008 |
| 20080220022 | Salmonella Vaccine - The present invention relates to the field of vaccination against | 09-11-2008 |
| 20080220023 | ANTIFUNGAL VACCINES WITH SACCHAROMYCES CEREVISIAE - Methods and formulations for vaccinating induce in mammals that are vaccinated protective immunity against diseases caused by fungi. The vaccines include a yeast, such as | 09-11-2008 |
| 20080220024 | ANTIFUNGAL VACCINES WITH SACCHAROMYCES CEREVISIAE - Methods and formulations for vaccinating induce in mammals that are vaccinated protective immunity against diseases caused by fungi. The vaccines include a yeast, such as | 09-11-2008 |
| 20080220025 | Treating Tumors Using Implants Comprising Combinations of Allogeneic Cells - This invention provides methods and compositions for treating tumors. The cell population is made up of alloactivated lymphocytes from the patient or from one or more third-party donors that are alloactivated in a mixed lymphocyte culture. It can be placed into the tumor bed, or combined with tumor-associated antigen for administration to a distal site as a vaccine. The compositions recruit activated participation of the host Immune system, which then reacts against the tumor and provides a level of ongoing protection. Employing multiple third party donor cells confers particular advantages in terms of effectiveness, timing, and ease of use. | 09-11-2008 |
| 20080220026 | Mesoporous material compositions and methods of their use for improving the appearance of biological surfaces - The present invention relates to compositions and methods for treating and improving the aesthetic appearance of a biological surface by altering the optical properties of the biological surface, thereby resulting in a natural appearance. The compositions of the invention may be topically applied to the biological surface, including but not limited to skin, in an amount effective in improving the aesthetic and natural appearance of the biological surface. | 09-11-2008 |
| 20080220027 | Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases - Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases. | 09-11-2008 |
| 20080220028 | ARCHAEAL POLAR LIPID AGGREGATES FOR ADMINISTRATION TO ANIMALS - The invention provides non-replicating compositions, and methods for the delivery of these compositions containing pharmaceuticals, biologically relevant molecules, and/or antigens to the host, by administration via a mucosal route such as the intranasal. This invention provides non-replicating vaccine compositions and methods for the delivery of antigens in these vaccine compositions comprising an antigen and a self-adjuvanting carrier, useful for inducing antigen-specific mucosal and systemic immune responses in the host upon immunization via a mucosal route such as intranasal. The vaccine compositions comprise multivalent cations in association with a plurality of spherical archaeal polar lipid aggregates containing aqueous compartments, the AMVAD structure, formed by the interaction of archaeosomes and antigen(s) with multivalent cations such as Ca | 09-11-2008 |
| 20080220029 | Fast-dissolving/disintegrating film preparation having high proportion of active - The invention provides a fast-dissolving or fast-disintegrating film preparation having a high proportion (i.e., at least about 40%) of active agent(s) and related methods for its preparation. In one embodiment, the active agent is a pharmaceutical and the film comprises between about 10% and about 40% pullulan as a primary or sole water-soluble polymer. | 09-11-2008 |
| 20080220030 | Nanoparticles Comprising Chitosan and Cyclodextrin - This invention relates to a system comprising nanoparticles designed for the release of biologically active molecules, where the nanoparticles comprise a) at least 40% by weight of chitosan or a derivative thereof and b) less than 60% by weight of a cyclodextrin or a derivative thereof, where both components a) and b) are mixed, without any covalent bond between them. This system allows for the efficient association of biologically active molecules, as well as their subsequent release in a suitable biological environment. | 09-11-2008 |
| 20080220031 | Dermocosmetic Preparations - The present invention relates to dermocosmetic compositions comprising a compound comprising the structural element of the formula I | 09-11-2008 |
| 20080220032 | ORAL CARE LAYER AND RELATED METHOD OF MANUFACTURE - An oral care composition including a hydrophilic, aliphatic, polyether-based thermoplastic polyurethane, a glycol polymer, and a poly(N-vinyl lactam). These components form a tacky film having a thickness of about 1 mils to about 50 mils. A whitening agent, such as a peroxide, can be absorbed into the tacky film, and adapted to desorb from the tacky film to whiten teeth to which the film is joined. A method is also provided in which the components are extruded through a twin screw extruder and output to a die to produce the film. The whitening agent can be deposited on the film and absorbed by the film to form a relatively stable oral care composition including the whitening agent. | 09-11-2008 |
| 20080220033 | Cosmetic ingredient and cosmetic composition containing the same - The invention provides a cosmetic ingredient and cosmetic compositions containing the same that exhibit skin protection/recovery properties and which are suitable for use in various cosmetic forms, such as skin care cosmetics, makeup cosmetics and skin cleansing agents. The cosmetic ingredient and cosmetic compositions containing the same include spherical sulfated cellulose or a salt thereof prepared by sulfate esterification of a part of the hydroxy groups of spherical cellulose. | 09-11-2008 |
| 20080220034 | Antiadhesive Polymers for Prevention of Adhesion of Microorganisms to Textiles and for Prevention of Laundry Odor - Textile treatment agents and/or capsules comprising a polymer having antiadhesive action against microorganisms which adhere to a textile substrate, methods of treating textile substrates therewith and the textile so treated, wherein the polymer comprises a polymeric structural element selected from the group consisting of polyesters, polysaccharides, polyethers, polyurethanes, polyureas, polyamides, and heteropolymers thereof. | 09-11-2008 |
| 20080220035 | Training spray - A composition for deterring a domestic pet from intruding upon a designated area. The composition includes a citrus oil, foaming and wetting agents in an aqueous carrier. The composition is particularly effective when applied in the form of a mist or spray deterring a cat from scratching furniture or related items. | 09-11-2008 |
| 20080220036 | Antimicrobial Packaging Material - An antimicrobial packaging material for food stuffs containing from 0.05% to 1.5% by weight of a natural essential oil. The oil can be selected from primarily linalool and/or methylchavicol, but also from one or more of citral, geraniol, methyl cinnamate, methyl eugenol, 1,8-cineole, trans-a-bergamotene, carvacrol and thymol blended with one or more polymers selected from ethylene vinyl alcohol copolymer, polyacrylates, including ethyl acrylate methyl methacrylate copolymers, lonomers, nylons and other hydrophilic polymers or polymers possessing functional groups capable of partially anchoring the additives and the blender mix is coated onto the food contact face of a food grade packaging film or incorporated into a food grade packaging film. A binding agent such as polyethylene glycol is added to the blend to improve the retention of the volatile oil in the polymer during processing. This material has no regulatory limitations and, at the referred concentrations, does not form detectable off-flavours. | 09-11-2008 |
| 20080220037 | Biphosphonic Compounds For Preventing Or Limiting Fixing Of Macromolecules, Microorganisms And Biofilm On Solid, In Particular Metal Or Mineral Surfaces - The invention concerns biphosphonic compounds of formula (I); microbiological anti-contamination compositions containing same, and their use for preventing or limiting fixing of macromolecules, micro-organisms and biofilm on solid surfaces, such as metal or mineral surfaces. | 09-11-2008 |
| 20080220038 | Nematicidal Compositions and Methods of Using Them - There is disclosed method of killing nematodes comprising the step of applying an effective amount of a nematicidal composition comprising a terpene component and compositions suitable for use in the method. The terpene component is preferably in association with water, either as a solution or a suspension. An excipient may also be included, which is suitably hollow glucan particles which encapsulate the terpene component. | 09-11-2008 |
| 20080220039 | Thin Film Medical Devices Manufactured on Application Specific Core Shapes - A method for creating three-dimensional, unitary, thin film medical devices for implantation within a human subject is provided, along with a method for creating pores within such thin film devices. Using known sputtering methods, a film material is implanted on a core or combination of cores having an advanced threedimensional geometry, then the core is removed from the finished thin film device. The core may be provided with raised features at portions which are to be removed from the thin film device. Once the film has formed on the core, the portions of the film overlying the raised portions may be removed using mechanical means, such as grinding. Additionally, a kit can be provided having a plurality of the described thin film devices which may be used together for advanced surgical procedures. | 09-11-2008 |
| 20080220040 | Nitric Oxide Donating Medical Devices and Methods of Making Same - Disclosed are implantable medical devices comprising nitric oxide (NO) donating polymers comprising polymer backbones having at least one cyclic amine disposed thereon. Methods are further disclosed for providing nitric oxide-donating polymers. | 09-11-2008 |
| 20080220041 | Medical devices having improved performance - In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block. | 09-11-2008 |
| 20080220042 | Biomolecule-linked biomimetic scaffolds - The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer are aligned, and a molecule is covalently attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human. | 09-11-2008 |
| 20080220043 | Repair of larynx, trachea, and other fibrocartilaginous tissues - Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal. | 09-11-2008 |
| 20080220044 | CANCELLOUS CONSTRUCT WITH SUPPORT RING FOR REPAIR OF OSTEOCHONDRAL DEFECTS - The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section. | 09-11-2008 |
| 20080220045 | Self-setting polymeric cyanoacrylate composites - Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration. | 09-11-2008 |
| 20080220046 | Terpolymers for Controlled Release of Bioactive Agents From Implantable Medical Devices - Disclosed herein are implantable medical devices comprising controlled release terpolymers and at least one drug releasable from said terpolymers coating. The terpolymers of the present invention are comprised of acrylate and/or vinyl monomers. | 09-11-2008 |
| 20080220047 | Low-swelling biocompatible hydrogels - Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column. | 09-11-2008 |
| 20080220048 | Nitric Oxide-Releasing Biodegradable Polymers Useful as Medical Devices and Coatings Therefore - Nitric Oxide (NO)-releasing polymers useful as implantable medical devices and coatings therefore are provided. Specifically the implantable medical devices and/or coatings comprise NO-releasing biodegradable polymers derived from [1,4]oxazepan-7-one and its derivatives. The medical devices and coatings of the present invention can also be used for in situ controlled release delivery of additional bioactive agents and are useful for treating or preventing medical conditions such as restenosis, aneurysms and vulnerable plaque. | 09-11-2008 |
| 20080220049 | Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins - The present disclosure relates to novel sustained-release intraocular drug delivery systems and improvements in the treatment of retinopathies. In particular, fibronectin scaffold domain proteins that selectively inhibit VEGFR-2 are contemplated. | 09-11-2008 |
| 20080220050 | Compositions For Gingival Retraction And Other Methods - At least one clay, at least one glass filler, and at least one astringent agent are formulated with water into a paste for injection in dental and medical applications. In one embodiment, the paste is used to treat and/or widen a gingival sulcus. The paste is readily rinsed off the surface to which it is applied using water. | 09-11-2008 |
| 20080220051 | Powdery Sterol Compositions Containing Colloid-Forming Agents - Compositions in powder form of sterols, stanols, and esters thereof, and natural macromolecular colloid formers are disclosed. A process of making the compositions is also disclosed. The suitability of incorporation of the compositions in powder form in food products, for example beverages and milk products, is also disclosed. | 09-11-2008 |
| 20080220052 | Body weight gain inhibitor - The invention provides a body weight gain inhibitor, a fat amount gain inhibitor, a medicament for prevention and/or treatment of obesity, a food composition having inhibitory effect on body weight gain and a food composition having inhibitory effect on fat amount gain, each containing ε-polylysine or a salt thereof. In another aspect of the invention, the described compositions are useful for inhibiting body weight gain, inhibiting fat amount gain and preventing and/or treating obesity. | 09-11-2008 |
| 20080220053 | Process for the Preparation of Two and Three Dimensional Polymer Scaffolds - A process for the preparation of polymer scaffolds containing a pharmacologically and/or biologically active protein molecule involving the following steps: neutralisation of the scaffold with a basic substance or a buffer solution; drying the scaffold; imbibition of the scaffold with a predefined quantity of a pharmacologically and/or biologically active protein molecule. | 09-11-2008 |
| 20080220054 | MODULATION OF DRUG RELEASE RATE FROM ELECTROSPUN FIBERS - Disclosed are co-electrospun polymeric fibers comprising polymers comprising pharmaceutically active agents and/or biologically active agents and capable of release at a combined release rate. Also disclosed are processes for preparing polymeric fibers capable of release at a combined release rate. Also disclosed are processes of modulating delivery rate of pharmaceutically active agents and/or biologically active agents. Also disclosed are processes of delivering pharmaceutically active agents and/or biologically active agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-11-2008 |
| 20080220055 | Therapeutic composition with enhanced endothelium targeting - A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed. | 09-11-2008 |
| 20080220056 | Treatment for liver disease - The present invention is based on the finding that the artificial induction of hepatic stellate cell (HSC) apoptosis in vivo can promote the resolution of liver fibrosis. Thus, the present invention provides methods for treating liver disease in a subject involving administration of an inducer of apoptosis which is capable of selectively inducing hepatic stellate cell apoptosis in the liver of the subject or of an agent which is capable of giving rise to such an inducer in the subject. In addition, the invention provides methods for treating liver fibrosis in a subject comprising the selective delivery of an inducer of apoptosis specifically to the hepatic stellate cells of the subject or of an agent which is capable of giving rise to an inducer of hepatic stellate cell apoptosis. | 09-11-2008 |
| 20080220057 | THERAPEUTIC COMPOUNDS AND METHODS OF USE - Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. | 09-11-2008 |
| 20080220058 | Method and composition for improving hair growth - A method and composition for improving human hair, having a composition of neutraceuticals that include | 09-11-2008 |
| 20080220059 | Pharmaceutical preparation of
N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide - The invention relates to a pharmaceutical preparation for oral administration comprising N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide or its hydrates and/or solvates, as well as an acid, a method for its production as well as the use of this preparation for the treatment and/or prophylaxis of diseases which are caused by herpes viruses, in particular diseases which are caused herpes simplex viruses. | 09-11-2008 |
| 20080220060 | Gastroretentive Formulations and Manufacturing Process Thereof - The present invention concerns gastroretentive formulation comprising an active substance granulated with a mixture of a weak gelling agent, a strong gelling agent, and a gas generating agent and process for manufacturing said formulation. | 09-11-2008 |
| 20080220061 | System for manufacturing controlled release dosage forms, such as zero-order release profile dosage form manufactured by three-dimensional printing - The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms. | 09-11-2008 |
| 20080220062 | Sustained release of agents for localized pain management - The invention relates to the treatment of localized pain by providing sustained release of an agent suitable for treating pain, methods for preparing and administering the agent, and methods of formulating and administering the agent as a pharmaceutical preparation. The agent can be locally administered to reduce systemic concentrations of the agent. | 09-11-2008 |
| 20080220063 | Biologic-Chemical Fungicide Compositions and Methods of Use - The present invention is directed to biologic-chemical fungicide compositions (BCFs) that include one or more chemical fungicides, and microorganisms including gram-positive and/or gram-negative bacteria and yeast. Any chemical fungicide or combination of fungicides can be used. The BCFs typically also include an optional nutrient component in an amount sufficient to support the growth and replication of the microorganisms. If the BCF is applied to soil rich in nutrients, or if the crops would support the growth of the microorganisms in the BCFs, then the nutrients can be left out. Compositions having a biologic component of microorganisms in addition to one or more chemical fungicides are significantly more effective than chemical fungicides applied without microorganisms. The invention is also directed to chemical-free biologic fungicides that contain microorganisms with suppressive activity against pathogenic fungi, and nutrients. | 09-11-2008 |
| 20080220064 | EXTENDED RELEASE MATRIX FORMULATIONS OF MORPHINE - The present invention provides extended-release matrix formulations comprising a therapeutically effective amount of morphine or salt thereof, one or more hydrophilic controlled release polymers and one or more pharmaceutically acceptable excipients. The formulations provide extended release of morphine or salt thereof over a specified period of time after oral administration in humans or animals. | 09-11-2008 |
| 20080220065 | Compositions for treating foot odor and methods of use thereof - A composition and method of use thereof for treating foot odor caused by microbial organisms, wherein cupric polyatomic salt is utilized as the active ingredient, preferably in combination with a dispersal agent, and wherein healthy tissue is promoted and foot odor is eliminated. | 09-11-2008 |
| 20080220066 | Anti-Viral Topical Gel Formulations Containing a Diuretic Such as Furosemide and/or a Cardiac Glycoside Such as Digoxin - An anti-viral topical gel formulation comprising at least one loop diuretic and/or cardiac glycoside in a gel carrier medium, said formulation capable of transdermal delivery of the said diuretic and/or glycoside. | 09-11-2008 |
| 20080220067 | ANTIMICROBIAL ADHESIVE SYSTEM - An adhesive composition having dispersed therein a broad spectrum antimicrobial agent for use in medical applications, such as an adhesive for surgical drapes, wound dressings and tapes, is provided. The adhesive is composed of acrylic polymers, tackifiers and a preferred antimicrobial agent, diiodomethyl-p-tolylsulfone. The subject adhesive composition may be formulated as either an essentially solventless hot melt, or as a solvent based system wherein an emulsion of the antimicrobial agent and the removal of excess solvent is avoided. | 09-11-2008 |
| 20080220068 | TREATMENT AND PREVENTION OF EXCESSIVE SCARRING - A pharmaceutical composition comprised of a hydration agent and an anesthetic can be used to treat excessive scarring conditions, such as keloid and hypertrophic scars. | 09-11-2008 |
| 20080220069 | Long Acting Injectable Crystal Formulations of Estradiol Metabolites and Methods of Using Same - The present invention provides sustained release formulations of estradiol metabolites whereby the in vivo pharmacokinetics are manipulated by a method selected from the group consisting of chemical modification, crystal packing formation, particle size or a combination thereof. Such compositions are useful in the long-term treatment of a wide variety of diseases. | 09-11-2008 |
| 20080220070 | Controlled release system and manufacturing method thereof - A controlled release system and manufacturing method thereof. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere. | 09-11-2008 |
| 20080220071 | Aqueous Suspensions of Poorly Water-Soluble and Water-Insoluble Active Ingredients and Drying Powder Produced Therefrom - Aqueous suspensions comprising: (a) at least one sparingly water-soluble or water-insoluble active agent in the form of nanoparticulate particles; (b) at least one whey component selected from the group consisting of whey proteins, whey protein hydrolysates, and mixtures thereof; and (c) at least one sucrose fatty acid ester having an HLB value of 10 to 18; processes for preparing such aqueous suspensions; powders and oil-miscible compositions prepared therefrom and uses therefore. | 09-11-2008 |
| 20080220072 | BIOLOGIC MODULATIONS WITH NANOPARTICLES - Certain aspects of the invention relate to the use of small particles in biological systems, including the delivery of biologically active agents to cells or tissues using nanoparticles of less than about 200 nm in approximate diameter. Embodiments include collection of particles having a bioactive component, a surfactant molecule, a biocompatible polymer, and a cell recognition component, wherein the cell recognition component has a binding affinity for a cell recognition target. Compositions and methods of use are also set forth, including the use of antisense directed against Protein Kinase CK2, CK2alpha, CK2 alpha′, and CK2 beta. | 09-11-2008 |
| 20080220073 | The Treatment of Respiratory Diseases - A pharmaceutical composition for pulmonary delivery comprises glycopyrrolate in a controlled release formulation, wherein, on administration, the glycopyrrolate exerts its pharmacological effect over a period greater than 12 hours. | 09-11-2008 |
| 20080220074 | GAMMA RADIATION STERILIZED NANOPARTICULATE DOCETAXEL COMPOSITIONS AND METHODS OF MAKING SAME - Nanoparticulate compositions comprising docetaxel or a salt, derivative, conjugate or analogue thereof, wherein the compositions are terminally sterilized via gamma radiation, are described, as well as methods of making and using such compositions. | 09-11-2008 |
| 20080220075 | Nanoparticulate compositions of angiogenesis inhibitors - Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions. | 09-11-2008 |
| 20080220076 | Active Agent Formulations, Methods of Making, and Methods of Use - Active agent compositions comprising active agent particles having an effective average particle size of less than 2000 nm, wherein the compositions comprise a particle sequestrant are disclosed. Compositions having an effective average particle size of less than 2000 nm, wherein the compositions comprise no added surfactants, phospholipids, or combinations thereof, are also disclosed. | 09-11-2008 |
| 20080220077 | MICROSPHERES FOR ACTIVE EMBOLIZATION - The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions. | 09-11-2008 |
| 20080220078 | Pharmaceutical Formulations - A pharmaceutical formulation for delivery in aerosol or spray form, comprising a liquefied propellant gas, a solid particulate pharmaceutically active agent and a dispersing agent, wherein the dispersing agent is fused to the surface of particles of the pharmaceutically active agent. | 09-11-2008 |
| 20080220079 | SUSTAINED RELEASE COMPOSITIONS USING WAX-LIKE MATERIALS - Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising said pellets and methods for preparing and using such pellets and dosage forms are also provided. | 09-11-2008 |
| 20080220080 | Multiparticulate Pharmaceutical form Comprising Pellets with a Substance Having a Modular Effect in Relation to Active Ingredient Release - The invention relates to a multiparticulate pharmaceutical form, comprising pellets with a multilayer structure for controlled active ingredient release, comprising a) a core layer comprising a substance having a modulating effect, b) an inner controlling layer which influences the delivery of the substance having a modulating effect, consisting of pharmaceutically usable polymers, waxes, resins and/or proteins, c) an active ingredient layer comprising an active pharmaceutical ingredient and, where appropriate, a substance having a modulating effect, d) an outer controlling layer comprising at least 60% by weight of one or a mixture of a plurality of (meth)acrylate copolymers where the layers may additionally and in a manner known per se comprise pharmaceutically usual excipients, where the outer controlling layer d) has a thickness from 20 to less than 55 μm and contains 0.1 to 10% by weight of glycerol monostearate, where the multiparticulate pharmaceutical form contains 20 to 60% by weight of the pellets, which are compressed in mixture with 80 to 40% by weight of an outer phase which consists from 50 to 100% by weight of a cellulose or a derivate of cellulose and optionally 0 to 50% by weight of further pharmaceutical excipients. | 09-11-2008 |
| 20080220081 | Water-Dispersible Xanthan Gum Containing Composition - One aspect of the present invention relates to a readily water-dispersible particulate composition comprising by weight of dry matter at least 10% of xanthan gum and not more than 60% of starch, said composition being characterised in that the xanthan gum present in the composition can be dispersed completely within 2 minutes in distilled water of 25° C. at a concentration of 0.7% based on the dry weight of xanthan. The particulate xanthan gum compositions of the present invention exhibit unique viscosity enhancing properties that are dependent on the electrolyte levels of the aqueous environment in which they are applied. The favourable properties of the xanthan compositions according to the invention can be realised without resorting to chemical modification of the xanthan gum. The xanthan compositions according to the present invention can be applied advantageously in e.g. food products and oil drilling fluids. | 09-11-2008 |
| 20080220082 | Compositions and methods for treating or preventing hair loss and processes for making the same - The present invention relates to composition useful in growing hair. The compositions are particularly suited for re-growing hair in subjects who have experienced hair loss due to any cause. The compositions comprise essentially the lipoidic fraction of mammalian bone marrow. Methods of using the compositions and processes of preparing the lipoidic fraction for the compositions are also disclosed. | 09-11-2008 |
| 20080220083 | Pharmaceutical Agent Comprising Blood Components <10 Kda And Their Use For Prophylaxis And Treatment Of Defects Of The Immune System - The invention relates to a composition of proteins, peptides and/or peptide components, a pharmaceutical agent comprising said composition, a method for the production of said composition and the use thereof in the prophylaxis or therapy of persons, animals and/or patients with pathogenic modifications and/or cellular immunodeficiencies, especially cancer, septicemia or allergic reactions, in connection with a cytostatic agent therapy, chemotherapy and/or radiotherapy. | 09-11-2008 |
| 20080220084 | COMBINATION THERAPY FOR ALLEVIATING PAIN-RELATED CONDITIONS - The present invention provides compositions and methods for alleviating physical discomfort and/or pain-related conditions in a subject, comprising one or more ingredients that improve blood circulation, one or more ingredients that reduce pain and one or more ingredients that enhance bone health. The ingredients are selected from synthetic compounds, natural products, natural ingredients, extracts from natural ingredients, or combinations thereof. The compositions of the invention are particularly useful in alleviating musculoskeletal pain and nerve related pain. | 09-11-2008 |
| 20080220085 | PRODUCTION OF NEURAL PROTECTIVE AND REGENERATIVE FACTORS FROM STEM CELLS AND TREATMENT OF NERVOUS SYSTEM CONDITIONS THEREWITH - A method for producing stem cell conditioned media for treatment of neurological insults is provided herein. By providing for the culture of adipose stem cells, and collecting the supernatants thereof, the supernatants have been shown to effect biological activity in preventing neural death when the supernatants are administered to a patient that has or is about to be subjected to a neural insult. | 09-11-2008 |
| 20080220086 | Injectable Composite Material Suitable for Use as a Bone Substitute - The invention relates to a new injectable composite material suitable for use as a bone substitute. The composite material according to the invention comprises a reactive ceramic phase based on tricalcium phosphate and an organic phase comprising a polyvinyl alcohol hydrogel. By varying the concentration of the two phases it is possible to modulate the mechanical and injectability properties of the material. | 09-11-2008 |
| 20080220087 | COLON CLEANSING COMPOSITION AND METHOD - A composition and method for cleansing a colon prior to endoscopic procedure. More particularly, a combination of bisacodyl, metoclopramide, sodium, and/or a phosphorus containing composition administered in sequential doses for preparing a colon prior to colonoscopy. | 09-11-2008 |
| 20080220088 | Composition for Treating Wounds and Burns - The invention discloses the use of a liquid composition, capable of promoting the growth of tissue cells at the site of a wound, a process that promotes regeneration of tissue and wound healing. More particularly, the present invention relates to the use of a liquid composition comprising a component (a) selected from the salts consisting of cations A | 09-11-2008 |
| 20080220089 | Medical agent for preventing or treating diseases resulting from one of inflammation and remodeling, and method for preventing or treating the diseases - An object of the present invention is to provide a medical agent that has an excellent effect on the diseases resulting from one of inflammation and remodeling and that can prevent or treat them in response to various mechanisms of onset and development of the diseases. Thus, the present invention relates to a medical agent for preventing or treating diseases resulting from one of inflammation and remodeling in blood vessel, including nanobubbles. | 09-11-2008 |
| 20080220090 | Anti tumor compositions and methods of use - An anti-cancer composition having biocompatible materials, which can selectively exploit chemical variations between normal cells and cancer cells to inhibit or prevent the proliferation of cancerous cells and methods of use. | 09-11-2008 |
| 20080220091 | REDUCTION OF REACTIVE OXYGEN SPECIES IN CHRONIC WOUND MANAGEMENT - Reactive oxygen species associated with a wound are modulated through treatment of the wound with a solution of metal ions selected from the group consisting of potassium ions, zinc ions, calcium ions and rubidium ions, at a pH of between about 5 and about 7. Preferably, citric acid is employed to adjust the pH of the solution. Application of the extract to a wound exhibiting superoxide anions has been found to be effective in the treatment of these wounds through the reduction of the level of superoxide anions. Moreover, treatment of partial thickness excision wounds as well as contact burn wounds with the present composition has been found to improve epithelialization of these wounds. In addition to the antioxidant activity of the present invention, treatment of the wound employing the present composition produces inhibitory effects on ROS production by human PMNs and on human complement activation, and therefore, is further beneficial in chronic wound management. | 09-11-2008 |
| 20080220092 | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like - Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, plant extracts, botanicals, nutraceuticals, cosmeceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures. | 09-11-2008 |
| 20080220093 | METHODS FOR PRODUCTION OF THE OXIDIZED GLUTATHIONE COMPOSITE WITH CIS-DIAMMINEDICHLOROPLATINUM AND PHARMACEUTICAL COMPOSITIONS BASED THEREOF REGULATING METABOLISM, PROLIFERATION, DIFFERENTIATION AND APOPTOTIC MECHANISMS FOR NORMAL AND TRANSFORMED CELLS - The present invention relates to a composite for the treatment of a variety of medical conditions, the composite comprising an oxidized gluthathione-based compound, which has a disulfide bond, and a metal material, in particular where the metal is either platinum or palladium. The oxidized glutathione-based compound and metal material can be present in a ratio of 3000 to 1 and preferably 1000 to 1. The oxidized glutathione-based compound can be oxidized glutathione itself or salts or derivatives. A feature of the invention is that the composite has a more stabilized disulfide bond than the oxidized glutathione-based compound itself. Methods for preparing the composite are provided, such methods being beneficial in that the composite is provided in high yields and at high purity. Methods for treating various medical conditions with the composites of the present invention are also disclosed. | 09-11-2008 |
| 20080220094 | Compositions and methods for the treatment and/or prevention of osteoporosis - The invention of this application relates to compositions and methods for the treatment and/or prevention of osteoporosis; improving and/or enhancing bone formation; and prevention and/or reducing bone mineral density loss. More particularly, the invention relates to a composition comprising vitamin K, in any form and betacryptoxanthin. A further aspect of this invention is a composition comprising vitamin K, in any form, betacryptoxanthin, and/or vitamin D and/or calcium. | 09-11-2008 |
| 20080220095 | Red blood cells loaded with s-nitrosothiol and uses therefor - Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO | 09-11-2008 |
| 20080220096 | CYNARA SCOLYMUS EXTRACTS AND COMPOSITIONS CONTAINING THEM - The present invention relates to a | 09-11-2008 |
| 20080220097 | FORMULATIONS CONTAINING CYNARA SCOLYMUS AND PHASEOLUS VULGARIS EXTRACTS WHICH ARE USEFUL IN THE TREATMENT OF OBESITY - The present invention relates to a | 09-11-2008 |
| 20080220098 | FORMULATIONS OF ALPHA-AMYLASE INHIBITORS WITH ALPHA-GLUCOSIDASE INNHIBITORS USEFUL IN THE TREATMENT OF DIABETES AND OBESITY - This invention relates to the combination of α-amylase inhibitors prepared from | 09-11-2008 |
| 20080220099 | Nutritional composition - A dietary supplement for dogs is disclosed. The composition is a blend of methyl sulfonyl methane, glucosamine sulfate, chondroitin sulfate, ascorbic acid, phylloquinone, yucca powder and stabilized rice bran. The composition may be added to a variety of meat products for dogs, preferably beef and/or beef by-products. | 09-11-2008 |
| 20080220100 | Fermented panax notoginseng solution with anti-cancer effects and manufacture method thereof - This invention relates to a fermented | 09-11-2008 |
| 20080220101 | COMPOSITIONS OF EXTRACTS OF ALOE FOR ORAL ADMINISTRATION - Compositions containing extracts of | 09-11-2008 |
