36th week of 2013 patent applcation highlights part 32 |
Patent application number | Title | Published |
20130230857 | HYBRID SELECTION USING GENOME-WIDE BAITS FOR SELECTIVE GENOME ENRICHMENT IN MIXED SAMPLES - The present invention provides methods for sequencing and genotyping of DNA useful for analysis of samples in which the target DNA represents a small portion (e.g., 10-1000-fold less) that a contaminating DNA source. Accordingly, the methods described herein are useful for sequencing or genotyping pathogen DNA, such as malaria DNA, in clinical samples taken from infected subjects. | 2013-09-05 |
20130230858 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations. | 2013-09-05 |
20130230859 | USE OF BLOOD GROUP STATUS - The present invention relates to use of the non-secretor/secretor blood group status of an individual as a criterion for need of | 2013-09-05 |
20130230860 | AUTOMATIC REAL-TIME PCR SYSTEM FOR THE VARIOUS ANALYSIS OF BIOLOGICAL SAMPLE - The present invention relates to an automatic real-time quantitative amplification system which can perform analysis of various biological samples, and more particularly to an automatic real-time quantitative amplification system in which a plurality of decks for respectively accommodating biological samples are put in a deck storing/transferring device, whereby it is possible to automatically analyze an amount or existence of a target substance containing a target nucleic acid in the biologic sample, such as a particular gene, a particular, a particular pathogenic bacterium and a particular protein, by amplifying the target nucleic acid purified by some processes of purification, purification after culture, or purification after reaction of the target substance contained in the bio-logical sample and then checking an amount of the amplified target nucleic acid. | 2013-09-05 |
20130230861 | METHOD FOR DETECTION OF IDIOPATHIC INTERSTITIAL PNEUMONIA - The present invention provides a method for detecting idiopathic interstitial pneumonia, which comprises measuring the expression level of a periostin gene or the amount of a periostin protein in a biological sample. Thereby, a method for detecting idiopathic interstitial pneumonia using a marker is provided. | 2013-09-05 |
20130230862 | METHODS TO IDENTIFY COMPOUNDS USEFUL FOR TUMOR SENSITIZATION TO DNA DAMAGE - Cdc25A is herein identified as a substrate for β-TrCP1- or β-TrCP2-mediated ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway. In particular, it has been found that interfering with β-TrCP expression or function, or increasing β-TrCP degradation, leads to accumulation of Cdc25A in a cell. Since degradation of Cdc25A is a key feature of the response to DNA damage, leading to a stall in the cell cycle during which the cell can repair the damage, Cdc25A accumulation can abolish this response, thereby sensitizing the cell to DNA damage. Described herein are assays for identifying β-TrCP inhibitors, and method of using such inhibitors for modulating Cdc25A degradation, sensitization of tumor cells, and as adjuvants in cancer therapy based on DNA damaging agents. | 2013-09-05 |
20130230863 | Target Molecules for Transcriptional Control Systems - The invention provides systems and methods for transcriptional control which employ target molecules. | 2013-09-05 |
20130230864 | METHOD FOR AND USE OF DIGITAL HOLOGRAPHIC MICROSCOPY AND IMAGING ON LABELLED CELL SAMPLES - The present invention relates to use of a digital holographic microscopy and imaging setup and a method of digital holographic microscopy and imaging for detecting molecules or structures stained or labelled to at least one cell or conjugated to antibodies which are bound either directly to said at least one cell or indirectly via another or several antibodies in a chain bound to said at least one cell. | 2013-09-05 |
20130230865 | Methods for Monitoring Methotrexate Therapy - The present invention provides methods for assessing efficacy of a methotrexate (MTX) dosing regimen in a patient. | 2013-09-05 |
20130230866 | Method for Determining Effectiveness of Medicine Containing Antibody as Component - Protein recognized by an antibody used as an active ingredient of an antibody medicine such as trastuzumab or an antibody used for targeting a target site of an active ingredient is highly accurately quantitatively determined by employing a quantitative tissue staining method of biological tissues, thereby providing a method for determining therapeutic effectiveness of a medicine containing such an antibody as a component. The effectiveness of a medicine containing an antibody as a component is determined by employing a tissue staining method comprising the steps of: labeling the antibody in the medicine containing an antibody as a component with a fluorescent material and contacting the thus fluorescence-labeled antibody with a tissue sample; obtaining a fluorescence image by irradiating, with excitation light, a tissue site contacted with the antibody; obtaining an autofluorescence image in the same field of view and at the same focus as in the fluorescence image in a close region on a shorter wavelength side or a longer wavelength side of an acquisition wavelength region of fluorescence emitted by the fluorescent material; obtaining a corrected fluorescence image by performing image processing for removing fluorescence brightness of the autofluorescence image from fluorescence brightness of the fluorescence image; counting the number of cells in the tissue site contacted with the antibody; measuring average fluorescence brightness per fluorescent particle; and calculating the number of fluorescent particles per cell. | 2013-09-05 |
20130230867 | Software Integrated Flow Cytometric Assay For Quantification Of The Human Polymorphonuclear Leukocyte FCgammaRI Receptor (CD64) - A composition for evaluating a biological condition is disclosed. The composition has (a) a sample composition comprising at least one of: i.) a bodily specimen comprising a target moiety; ii.) a positive control moiety; and iii.) a negative control moiety; (b) an antibody composition comprising at least one of: i.) at least one target antibody; ii.) at least one positive control identifying antibody; and iii.) at least one negative control identifying antibody; and (c) at least one reference composition comprising at least one of: i.) a target signal reference composition; and ii.) a reference identifier composition. | 2013-09-05 |
20130230868 | Screening process for finding samples having a functionality disorder of the GPIb-von Willebrand factor interaction - The invention relates to a screening process for determining a disordered von Willebrand factor (VWF)-GPIb interaction in a patient's sample. This comprises contacting the sample with isolated GPIbα protein, with VWF protein and with a solid phase associated with an antibody specific for said isolated GPIbα protein, and determining complex formation. | 2013-09-05 |
20130230869 | ANTIBODY AGAINST COLORECTAL CANCER MARKER - The purpose of the present invention is to provide a novel monoclonal antibody which binds to SLC6A6 or an extracellular domain thereof. The present invention relates to a monoclonal antibody which recognizes native SLC6A6 or a polypeptide of an extracellular domain of SLC6A6. | 2013-09-05 |
20130230871 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Interleukin-5, Interleukin-6 receptor subunit beta, Tissue factor, Sex hormone-binding globulin, Alpha-2-macroglobulin, Apolipoprotein A-I, Calcitonin, Thrombopoietin, C-reactive protein, Intercellular adhesion molecule 3, Macrophage metalloelastase, Apolipoprotein B-100, and Fibrinogen as diagnostic and prognostic biomarkers in renal injuries. | 2013-09-05 |
20130230872 | PLASMID VECTOR, METHOD FOR DETECTING GENE PROMOTER ACTIVITY, AND ASSAY KIT - According to one embodiment, a first gene encodes a reporter protein. The first gene is disposed at the downstream of the gene promoter. A second gene is disposed at the downstream of the gene promoter and encodes a replication origin-binding protein. An internal ribosome entry site is disposed between the first gene and the second gene. The transcription termination signal sequence encodes a signal for terminating the transcription of the first gene and the second gene. A replication origin sequence is recognized by the replication origin-binding protein. | 2013-09-05 |
20130230873 | METHOD FOR QUANTIFICATION OF REMNANT-LIKE LIPOPROTEIN CHOLESTEROL AND KIT FOR SAME - A method for quantifying remnant-like lipoprotein cholesterol in a sample simply and accurately without requiring separation operations, and a kit therefor are disclosed. A method for quantifying cholesterol in a remnant-like lipoprotein in a sample containing different lipoproteins including the remnant-like lipoprotein comprises a step (1) of erasing cholesterol in lipoproteins other than the remnant-like lipoprotein; and a step (2) of quantifying cholesterol in the remaining remnant-like lipoprotein. The step (1) is carried out under an action of a cholesterol esterase having a molecular weight of more than 40 kDa and not having a subunit having a molecular weight of not more than 40 kDa; and the step (2) is carried out under an action of a cholesterol esterase having a molecular weight of not more than 40 kDa or a cholesterol esterase having a subunit having a molecular weight of not more than 40 kDa. | 2013-09-05 |
20130230874 | OPTICAL ANALYSIS METHOD USING MEASUREMENT OF LIGHT OF TWO OR MORE WAVELENGTH BANDS - There is provided an optical analysis technique enabling identification of a kind of light-emitting particle corresponding to a signal on a time series light intensity data or identification of a signal corresponding to light-emitting particles other than a particle to be observed in an optical measurement using a confocal microscope or a multiphoton microscope. The inventive optical analysis technique measures simultaneously and separately intensities of lights of two or more wavelength bands from a light detection region in a sample solution containing light-emitting particles of two or more kinds to generate time series light intensity data of the respective wavelength bands; detects signals simultaneously generated on the time series light intensity data of at least two wavelength bands; and identifies the simultaneously generated signals as signals of a light-emitting particle of at least one specific kind. | 2013-09-05 |
20130230875 | Enzymatic Assays for a Droplet Actuator - A method is provided for conducting a droplet-based enzymatic assay, e.g., for diagnostic purposes. On a droplet actuator, a droplet comprising an enzyme of interest is provided along with a droplet comprising a substrate which is potentially modified in the presence of the enzyme. Droplet operations are executed to combine the enzyme and substrate droplets on the droplet actuator, thereby yielding an assay droplet on the droplet actuator. Detecting modification of the substrate by the enzyme in the assay droplet occurs on the droplet actuator. Modified substrate preparations for conducting such enzymatic assays are also provided. | 2013-09-05 |
20130230876 | METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY - Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided. | 2013-09-05 |
20130230877 | Compositions, Methods and Kits for Diagnosis of Lung Cancer - Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC) | 2013-09-05 |
20130230878 | METHOD FOR PRODUCING MONOTERPENE AND MONOTERPINOID COMPOUNDS AND USE THEREOF - In various embodiments, the present disclosure provides a method and enzyme for forming various compounds, such as monoterpenes and monoterpenoid compounds. In a specific example, the present disclosure provides a method for producing one or more of (−)-ipsdienol, (−)-ipsenol, ipsenone, and ipsdienone. The present disclosure also provides methods of using compounds formed from the disclosed method and enzyme. | 2013-09-05 |
20130230879 | OPTICAL ALIGNMENT DEFORMATION SPECTROSCOPY - A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object. | 2013-09-05 |
20130230880 | DEVICE AND METHOD FOR ANALYSIS OF BIOLOGICAL SPECIMENS - The invention relates to a device and a method for analysis of biological specimens. The device has a control unit into which a kit can be inserted that contains markers required for the analysis of a biological specimen and test records needed therefore. The markers and instructions from the test records are transferred from the kit to the control unit and from thence fed to the individual units of the device. | 2013-09-05 |
20130230881 | METHOD AND APPARATUS FOR TESTING CARDIOTOXICITY AND EVALUATING CARDIOMYOCYTES - In the present invention, a cardiomyocyte cluster is disposed on a transparent substrate, and the quality of the cardiomyocytes is evaluated from the response of the cells to a forced pulsation stimulus applied to the cardiomyocytes. The cardiomyocyte cluster is disposed on the transparent substrate, and is exposed to the flow of a liquid containing an agent in a manner so that the agent acts on the cells, which configure a network. The extent of cardiac toxicity resulting from the agent is evaluated from measuring the fluctuations obtained from a comparison of adjacent cardiomyocytes of the network. | 2013-09-05 |
20130230882 | CULTURE METHOD RELATED TO DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO BLOOD CELLS - It is an object of the present invention to provide a method for efficient differentiation into blood cells. Specifically, in the present invention, when blood cells are produced from pluripotent stem cells such as ES cells or iPS cells in vitro, the cells are cultured under a low oxygen partial pressure to increase the efficiency of differentiating the pluripotent stem cells into hematopoietic progenitor cells, erythroid progenitor cells, and the like, so as to increase the number of finally obtained, desired blood cells. | 2013-09-05 |
20130230883 | METHODS FOR DETECTION AND CHARACTERIZATION OF ABNORMAL TISSUE AND CELLS USING AN ELECTRICAL SYSTEM - An apparatus for the diagnosis of a biological sample is disclosed. An embodiments of the apparatus includes a probe, a probe head distally connectable to the probe, the probe head further comprising a plurality of electrode elements thereby forming an electrode array where each electrode element is variably actuatable to apply an electrical signal to the biological sample; an RF signal source for applying the electrical signal to the electrode array; an electrode selector adapted and configured to switch the electrical signal from the RF signal source between the plurality of electrode elements; and a detection circuit for analyzing a dielectric property received from the biological sample. Methods and kits for diagnosing a biological sample are also disclosed. | 2013-09-05 |
20130230884 | Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation - The present invention provides reagents and methods for identifying translation enhancing elements, as well as isolated translation enhancing elements and their use in protein expression reagents and methods. | 2013-09-05 |
20130230885 | LOV-DOMAIN PROTEIN FOR PHOTOSENSITIVE DEFUNCTIONALIZATION - The present invention relates to the use of a protein comprising an LOV domain for the photosensitive defunctionalization of a molecule and to a method for the photosensitive defunctionalization of a target molecule. | 2013-09-05 |
20130230886 | Antibodies to TNF Alpha - Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids. | 2013-09-05 |
20130230887 | Synthetic Nucleic Acids for Polymerization Reactions - Compositions and methods are provided for inhibiting a polymerase from replicating non target DNA at a temperature below the amplification reaction temperature. The inhibitor is a synthetic nucleic acid which is single stranded but folds to form at least one double stranded region designed to melt at a temperature which is lower than the amplification reaction temperature, and at least one single stranded region where the single stranded region at the 5′ end contains at least one uracil or inosine and optionally a sequence at the 3′ end contains one or more derivative nucleotide or linkages. | 2013-09-05 |
20130230888 | Heterologous Expression of Fungal Cellobiohydrolase 2 Genes in Yeast - The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized cbh2 genes from the organisms | 2013-09-05 |
20130230889 | ULVAN LYASE, METHOD FOR MANUFACTURING SAME, AND USES THEREOF - The present invention notably relates to ulvan lyases, to nucleic acid sequences coding for these ulvan lyases, to vectors comprising these coding sequences, to a method of manufacturing these ulvan lyases, as well as to a method of degrading ulvans using these ulvan lyases and applicable applications to the degradation products of the ulvans. The ulvan lyases of the present invention, or ulvanolytic protein, are notably defined as proteins of 30 or 46 kD comprising the following four sequences in their peptide sequence: PNDPNLK, LLEVGNTGTFGSTGS, DLANPDNV and WNLPE. | 2013-09-05 |
20130230890 | Pseudonocardia SP. And Method For Preparing Deoxynyboquinone By Utilizing Same - The invention discloses a | 2013-09-05 |
20130230891 | PEROXISOME BIOGENESIS FACTOR PROTEIN (PEX) DISRUPTIONS FOR ALTERING POLYUNSATURATED FATTY ACIDS AND TOTAL LIPID CONTENT IN OLEAGINOUS EUKARYOTIC ORGANISMS - Methods of increasing the amount of polyunsaturated fatty acids (PUFAs) in the total lipid fraction and in the oil fraction of PUFA-producing, oleaginous eukaryotes, accomplished by modifying the activity of peroxisome biogenesis factor (Pex) proteins. Disruptions of a chromosomal Pex3 gene, Pex10p gene or Pex16p gene in a PUFA-producing, oleaginous eukaryotic strain resulted in an increased amount of PUFAs, as a percent of total fatty acids and as a percent of dry cell weight, in the total lipid fraction and in the oil fraction of the strain, as compared to the parental strain whose native Pex protein was not disrupted. | 2013-09-05 |
20130230892 | VARIANT SUCROSE TRANSPORTER POLYPEPTIDES - Variant sucrose transporter polypeptides that enable bacterial growth over a wide range of gene expression levels and sucrose concentrations are described. Additionally, recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided | 2013-09-05 |
20130230893 | RECOMBINANT BACTERIA COMPRISING NOVEL SUCROSE TRANSPORTERS - Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described. | 2013-09-05 |
20130230894 | Optimised Fermentation Media - The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of a substrate comprising CO. It more particularly relates to the addition of an inorganic sulfur source to a fermentation system such that one or more micro-organisms convert a substrate comprising CO to alcohols. In a particular embodiment, a microbial culture is provided with sodium polysulfide, wherein a substrate comprising CO is converted to products including ethanol and 2,3-butanediol. | 2013-09-05 |
20130230895 | METHOD AND DEVICE FOR UNIFORMLY TREATING ADHERENT CELLS - The invention relates to a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes | 2013-09-05 |
20130230896 | Covalently Immobilized Enzyme and Method To Make The Same - A composition of enzyme, polymer, and crosslinker forms a network of covalently bound macromolecules. The covalently immobilized enzyme preparation has enzymatic activity, and retains stable activity when dried and stored at ambient conditions. Methods for preparing an immobilized enzyme and methods for using the enzyme are disclosed. | 2013-09-05 |
20130230897 | COMPLEX OF LABELED PROBES AND WATER-SOLUBLE CARRIER - The purpose is to produce, with high reproducibility, a complex of labeled probes and a carrier, said complex being to be used for detecting and measuring a target substance to be measured with high sensitivity and high stability. The means for accomplishing the purpose is that a label is bound to a probe-water soluble carrier conjugate using specific binding of an avidin compound such as avidin, streptavidin, etc. to biotin, and the binding of the avidin compound to the probe is performed before the binding to the carrier. Namely, after conjugating the avidin compound to a substance which is capable of binding to the target substance, the conjugate is bound to a high-molecule water-soluble carrier to produce a complex of the avidinized probes and the water-soluble carrier. Then the complex of the avidinized probes and the water-soluble carrier is mixed with a biotinylated label. Thus, a stable complex of the labeled probes and the water-soluble carrier, which enables the highly sensitive detection and measurement of the target substance, can be obtained with high reproducibility via the specific binding of the avidin compound to biotin. | 2013-09-05 |
20130230898 | HYDROXYALKYL STARCH DERIVATIVES AND PROCESS FOR THEIR PREPARATION - The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidised reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group. | 2013-09-05 |
20130230899 | THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS OR ARTERIOSCLEROTIC DISEASE, AND DIAGNOSTIC AGENT FOR ARTERIOSCLEROSIS OR ARTERIOSCLEROTIC DISEASE - It is intended to ameliorate arteriosclerosis or arteriosclerotic disease through a pharmacological mechanism that reduces the size of the arteriosclerotic lesion. The agent of the present invention comprises a complex comprising an antibody binding to folate receptor β (FRβ) and a cytotoxin or a cytotoxic agent conjugated with the antibody, or the antibody as an active ingredient. | 2013-09-05 |
20130230900 | MAIZE CELLULOSE SYNTHASES AND USES THEREOF - The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants comprising said nucleic acids. | 2013-09-05 |
20130230901 | PROCESS FOR MAKING RECOMBINANT ANTIDOTE TO FACTOR XA INHIBITOR - Disclosed are methods and isolated cells useful for the improved production of function fXa derivative protein that acts as a fXa inhibitor antidote. One aspect relates to an isolated cell comprising the r-Antidote polynucleotide and Furin polynucleotide. Another aspect relates to a method for preparing the cleaved two-chain r-Antidote by expressing, in a cell, the pre-processed r-Antidote polypeptide and a Furin polypeptide. | 2013-09-05 |
20130230902 | CHIMERIC ADENOVIRUSES FOR USE IN CANCER TREATMENT - The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index. | 2013-09-05 |
20130230903 | PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES - The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the | 2013-09-05 |
20130230904 | LENSED AND STRIPED FLAT PANEL PHOTOBIOREACTORS - The surface or surfaces of the walls of a closed photobioreactor are modified to generate light and dark regions. For example, the interior and/or exterior surfaces of the walls of the photobioreactor's chamber can be modified such that they form or incorporate convex and/or concave lenses. The concavity and/or convexity of the lenses redirect incident light rays so that the light is focused to specific points within the chamber, creating multiple light and dark regions within the photobioreactor. Alternatively, or in addition, a pattern of opaque material can be utilized on the walls of the chamber to generate light and dark regions. The number, location and shape of the light and dark regions are controlled by the design of the concavities and/or convexities and/or opaque patterns incorporated into the various surfaces of the photobioreactor. | 2013-09-05 |
20130230905 | Apparatus for Embedding Tissue Samples - A histology tissue embedding apparatus including a reservoir for an-embedding medium and an outlet valve connected to the reservoir through which the embedding medium is dispensable, and including trigger means which control the operation of the outlet valve, the trigger means having a rest position in which the outlet valve is closed, wherein the rest position of the trigger means in relation to the outlet valve is adjustable. | 2013-09-05 |
20130230906 | MICROFLUID CARTRIDGE FOR MOLECULAR DIAGNOSTICS - A cartridge for carrying out a method of analyzing the nucleic acids contained in a sample, includes a main body ( | 2013-09-05 |
20130230907 | HIGH-THROUGHPUT SENSORIZED BIOREACTOR FOR APPLYING HYDRODYNAMIC PRESSURE AND SHEAR STRESS STIMULI ON CELL CULTURES - A bioreactor ( | 2013-09-05 |
20130230908 | REACTION PLATE ASSEMBLY, REACTION PLATE AND NUCLEIC ACID ANALYSIS DEVICE - Provided is a technology such that, in nucleic acid analysis, a high degree of freedom in loading or unloading a reaction plate can be obtained and a sample can be efficiently analyzed. A reaction plate assembly includes a reaction plate with one or more reaction wells, a visible light transmissive cover mounted on the reaction plate and covering the reaction wells, and a visible light transmissive weight member covering the cover. The reaction wells are disposed in an arc shape along the circumference of a circle with a predetermined radius r | 2013-09-05 |
20130230909 | METHODS FOR ACCURATE SEQUENCE DATA AND MODIFIED BASE POSITION DETERMINATION - Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data using circular pair-locked molecules. In some embodiments, the methods comprise calculating scores of sequences of the nucleic acid inserts by comparing the sequences to the known sequence of the nucleic acid insert, and accepting or rejecting repeats of the sequence of the nucleic acid sample according to the scores of one or both of the sequences of the inserts immediately upstream or downstream of the repeats of the sequence of the nucleic acid sample. | 2013-09-05 |
20130230910 | Apparatus and Method for Process Challenge Devices - A process challenge device tailored to mimic the resistance of a particular product to a particular biological inactivation, disinfection, or sterilization process, and used to challenge the process, thus providing a means to validate the efficacy of the process. The process challenge device is used by subjecting the device containing indicator organisms to an inactivation or sterilization process, and culturing any surviving indicator organisms as a means to assess the efficacy of procedures for the inactivation of microorganisms. The device uses a self-containing biological indicator (SCBI) with a biological indicator and media ampule located within a plastic vial. By altering the materials and/or configuration of the SCBI a wide range of resistances to sterilant gas processes may be achieved. | 2013-09-05 |
20130230911 | POROUS STRUCTURE WITH INDEPENDENTLY CONTROLLED SURFACE PATTERNS - Disclosed herein are systems and methods for manufacturing and using a cell culture support device. The device includes a plurality of polymer layers, each with at least one flow chamber defined therethrough. The device also includes a cross channel interface between the channels of different polymer layers. The cross channel interface includes a plurality of pores and a topographical pattern that is selected independent of the plurality of pores. Furthermore, the formation of the topographical pattern preservers the pores. | 2013-09-05 |
20130230912 | BASE BODY AND METHOD FOR MANUFACTURING BASE BODY - A base body includes: a base member; a channel provided in the base member, the channel having an inner wall surface and flowing a fluid; a fine vacuum hole provided in the inner wall, the fine vacuum hole causing the channel to communicate the outside of the base member other and having an opening; and a slow flow portion disposed at a position close to the opening of the fine vacuum hole in the inner wall surface, the slow flow portion slows a flow of the fluid, wherein at least a portion that configures the fine vacuum hole in the base member is formed of a single member. | 2013-09-05 |
20130230913 | MAGNETIC PARTICLE BASED BIOSENSOR - A biosensor system and method of its use for detecting particles on the surface of an integrated circuit is disclosed. The system can include a light source and a plurality of optical sensors formed on an integrate circuit. The particles can be positioned the surface of the integrated circuit whereby the particles can cast a shadow or shadows that reduces the amount of light transmitted from the light source to the optical sensors. The surface of the integrated circuit can include one or more optical sensing areas whereby the presence of one or more particles may significantly or measurably reduce the amount of light incident on one or more optical sensor. | 2013-09-05 |
20130230914 | CULTURE CONTAINER FOR ADHERENT CELLS AND METHOD FOR PRODUCING CULTURE CONTAINER FOR ADHERENT CELLS - A culture bag for culturing adherent cells is provided without requiring a highly clean production environment and a complex production step such as a masking step. An adherent cell culture vessel that is formed of a polyolefin is configured so that part or the entirety of the inner surface of the culture vessel has a static water contact angle of 95° or more, and has an advancing contact angle and a receding contact angle that satisfy the inequality “advancing contact angle−receding contact angle>25°” when water runs down along the inner surface. | 2013-09-05 |
20130230915 | Pasting Edge Heater - An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module. | 2013-09-05 |
20130230916 | SYSTEMS AND METHODS FOR RATIONAL SELECTION OF CONTEXT SEQUENCES AND SEQUENCE TEMPLATES - Provided are systems and methods for rational selection of context sequences and sequence templates including a computer implemented method for obtaining a repository of attributes sets where the attributes sets are statistically associated with a sequence template representing two or more context sequences. | 2013-09-05 |
20130230917 | Method of Forming Dendritic Cells from Embryonic Stem Cells - This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers. | 2013-09-05 |
20130230918 | NOVEL COLLECTIN - Novel collectin related molecules i.e., a novel collectin gene comprising a nucleotide sequence set out in SEQ ID NO: 1, and a novel collectin comprising an amino acid sequence set out in SEQ ID NO: 2, which are expected to exhibit anti-bacterial, anti-viral activity or the like especially in human body, and methods in which these molecules are used are provided. | 2013-09-05 |
20130230919 | ANIMAL PROTEIN-FREE MEDIA FOR CULTIVATION OF CELLS - The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes. | 2013-09-05 |
20130230920 | METHODS AND COMPOSITIONS RELATING TO POLYPEPTIDES WITH RNASE III DOMAINS THAT MEDIATE RNA INTERFERENCE - The present invention concerns methods and compositions involving RNase III and polypeptides containing RNase III domains to generate RNA capable of triggering RNA-mediated interference (RNAi) in a cell. In some embodiments, the RNase III is from a prokaryote. RNase III activity will cleave a double-stranded RNA molecule into short RNA molecules that may trigger or mediate RNAi (siRNA). Compositions of the invention include kits that include an RNase III domain-containing polypeptide. The present invention further concerns methods using polypeptides with RNase III activity for generating RNA molecules that effect RNAi, including the generation of a number of RNA molecules to the same target. | 2013-09-05 |
20130230921 | METHODS FOR ENRICHING PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTE PROGENITOR CELLS AND CARDIOMYOCYTE CELLS BASED ON SIRPA EXPRESSION - The present invention relates to methods for enriching pluripotent stem cell-derived cardiomyocyte progenitor cells and cardiomyocyte cells based on SIRPA expression. | 2013-09-05 |
20130230922 | NEUTRAL PROTEASE (NP) AND PRODUCT BY USING NEUTRAL PROTEASE FOR TISSUE DISSOCIATION AS WELL AS METHOD FOR THE PRODUCTION THEREOF - The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a recombinant production is mixed before the beginning of a tissue dissociation with a collagenase or a collagenase enzyme preparation with an individual dosage of the quantitative proportions of neutral protease and collagenase for improving the isolation results with respect to yield, viability and integrity of the cells. | 2013-09-05 |
20130230923 | Short Interfering Ribonucleic Acid (siRNA) for Oral Administration - Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification. | 2013-09-05 |
20130230924 | Equine Amniotic Fluid-Derived Multipotent Stem Cells and a Method for Producing the Same - The present invention relates to equine amniotic fluid-derived multipotent stem cells (eAF-MSCs) and a preparation method thereof. More particularly, the present invention relates to equine amniotic fluid-derived multipotent stem cells which exhibit all negative immunological characteristics with respect to the human markers, CD19, CD20, CD28, CD31, CD34, CD38, CD41a, CD62L, CD62P and CD200, and exhibit all positive immunological characteristics with respect to the human markers, CD44, CD90 and CD105, and have the ability to differentiate into ectoderm, mesoderm or endoderm-derived cells. | 2013-09-05 |
20130230925 | MOLECULAR SWITCHES AND METHODS FOR MAKING AND USING THE SAME - The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways. Libraries comprising the switches and expression vectors and host cells for expressing the switches are also provided. | 2013-09-05 |
20130230926 | SYSTEM AND METHOD FOR TESTING ENGINE LUBRICANTS - Systems and methods for testing an engine lubricant are provided. The system includes a heated block having at least one cavity therein, at least one test cylinder receiving the engine lubricant therein, and at least one heated test piston selectively disposable into the engine lubricant of the test cylinder whereby deposits are formable on the test piston. The test cylinder is positionable in the cavity of the heated block and heatable thereby. Taxi oils and/or gases may be added to facilitate testing. | 2013-09-05 |
20130230928 | SENSOR MEMBRANES FOR REAGENT FREE IMAGING OF DISSOLVED FERROUS IRON CONCENTRATIONS - A method for measuring iron concentration that includes providing a sensor including a substrate, a ferrozine containing reagent, and a polymer covalently bonding the ferrozine containing reagent on the substrate. The sensor is inserted into an iron (Fe) containing sample. The ferrozine containing reagant reacts with iron (Fe) ions in the iron (Fe) containing sample. The optical properties of the sensor are measured after the ferrozine containing reagent reacts with the iron (Fe) ions in the iron (Fe) containing sample to determine the concentration of the iron (Fe) ions in the iron (Fe) containing sample. | 2013-09-05 |
20130230929 | AGENT FOR DETECTING HALIDE, METHOD FOR DETECTING HALIDE, AND DETECTION SENSOR - [Problems to be solved by the invention] | 2013-09-05 |
20130230930 | TREATMENT OF A SAMPLE WITH FOCUSED ACOUSTIC ENERGY - A device for treating a sample with focused acoustic energy is provided. The device transmits the generated acoustic energy from the source to the sample via a complete dry propagation path. A cartridge containing the sample is inserted into an instrument, wherein the insertion forms a dry propagation path. | 2013-09-05 |
20130230931 | TARGET SUBSTANCE DETECTING APPARATUS, AND TARGET SUBSTANCE DETECTING METHOD - A target substance detecting apparatus includes a photonic crystal biosensor configured to include a photonic crystal, which has a reflection surface including concave portions and convex portions formed regularly on its surface, covered by a metal film, and reflecting light irradiated to the reflection surface; an optical detecting unit configured to irradiate parallel light to the reflection surface, and to detect reflected light of the parallel light reflected on the reflection surface; and a processing unit configured to obtain a wavelength at an extreme value of the reflected light detected by the optical detecting unit, and to detect at least whether the target substance is present or not based upon a shift of the obtained wavelength at the extreme value. | 2013-09-05 |
20130230932 | THROUGH-SUBSTRATE VIA (TSV) TESTING - Various embodiments comprise apparatuses and methods for testing and repairing through-substrate vias in a stack of interconnected dice. In various embodiments, an apparatus is provided that includes a number of through-substrate vias to couple to one or more devices, at least one redundant through-substrate via to allow a repair of the apparatus, and a pair of pull-up devices coupled to the through-substrate vias and the redundant through-substrate via to provide a high-data value to the first end of the respective through-substrate vias. A test register is coupled the second end of each of the through-substrate vias and the redundant through-substrate via to store a received version of the high-data value. A comparator compares the high-data value with the received version of the high-data value to test the through-substrate vias for short-circuit connections. | 2013-09-05 |
20130230933 | METHODS FOR FABRICATING THIN FILM SOLAR CELLS - A method for fabricating a thin-film solar cell. The method includes rolling a flexible substrate prepared with a metalized surface out of a roll to move linearly with a speed. The method further includes forming a back-electrode film overlying the metalized surface moving with the speed. Additionally, the method includes forming a stack of films comprising at least copper, gallium, and indium overlying the back-electrode film and forming a Se-alloy layer overlying the stack of films. Furthermore, the method includes depositing a Se—Na bearing film overlying the Se-alloy layer from a vacuum evaporator having at least two sources. Moreover, the method includes performing a thickness measurement in real time for the back-electrode film, the stack of films, and the Se-alloy layer on the flexible substrate moving with the speed to control the Se-alloy layer in a thickness of 10-100 nm corresponding to the Se—Na film in a thickness of 1-3 microns. | 2013-09-05 |
20130230934 | SYSTEM AND METHOD FOR MINIATURIZATION OF SYNTHETIC JETS - A micro-electromechanical (MEM) synthetic jet actuator includes a semiconductor substrate having a cavity extending therethrough, such that a first opening is formed in a first surface of the semiconductor substrate and such that a second opening is formed in a second surface of the semiconductor substrate. A first flexible membrane is formed on at least a portion of the front surface of the semiconductor substrate and extends over the first opening. The first flexible membrane also includes an orifice formed therein aligned with the first opening. The MEM synthetic jet actuator also includes a second flexible membrane that is formed on at least a portion of the second surface of the semiconductor substrate and that extends over the second opening, and a pair of actuator elements coupled to the flexible membranes and aligned with the cavity to selectively cause displacement of the first and second flexible membranes. | 2013-09-05 |
20130230935 | LED DEVICE WITH IMPROVED THERMAL PERFORMANCE - An apparatus includes a wafer with a number of openings therein. For each opening, an LED device is coupled to a conductive carrier and the wafer in a manner so that each of the coupled LED device and a portion of the conductive carrier at least partially fill the opening. A method of fabricating an LED device includes forming a number of openings in a wafer. The method also includes coupling light-emitting diode (LED) devices to conductive carriers. The LED devices with conductive carriers at least partially fill each of the openings. | 2013-09-05 |
20130230936 | SEMICONDUCTOR LIGHT EMITTING DEVICE, ITS MANUFACTURING METHOD, SEMICONDUCTOR DEVICE AND ITS MANUFACTURING METHOD - A semiconductor light emitting device made of nitride III-V compound semiconductors including an active layer made of a first nitride III-V compound semiconductor containing In and Ga, such as InGaN; an intermediate layer made of a second nitride III-V compound semiconductor containing In and Ga and different from the first nitride III-V compound semiconductor, such as InGaN; and a cap layer made of a third nitride III-V compound semiconductor containing Al and Ga, such as p-type AlGaN, which are deposited in sequential contact. | 2013-09-05 |
20130230937 | METHOD FOR MANUFACTURING PERPENDICULAR LED - A method for manufacturing a perpendicular LED for preventing bending of a wafer while reducing the time required for manufacturing to improve the mass production yield of perpendicular LEDs includes: growing an LED compound semiconductor structure on a sapphire substrate; forming an adhesive layer which is stacked on the LED compound semiconductor structure in the order of a first solder layer, a heat-emitting layer, and a second solder layer; forming a conductive substrate on the adhesive layer; coupling the first solder layer and the second solder layer by means of the heat which is generated from reacting the heat-emitting layer; and removing the sapphire substrate. | 2013-09-05 |
20130230938 | NITRIDE SEMICONDUCTOR LIGHT EMITTING DEVICE AND FABRICATION METHOD THEREOF - The present invention relates to a GaN based nitride based light emitting device improved in Electrostatic Discharge (ESD) tolerance (withstanding property) and a method for fabricating the same including a substrate and a V-shaped distortion structure made of an n-type nitride semiconductor layer, an active layer and a p-type nitride semiconductor layer on the substrate and formed with reference to the n-type nitride semiconductor layer. | 2013-09-05 |
20130230939 | HIGH ASPECT RATIO MEMS DEVICES AND METHODS FOR FORMING THE SAME - An HF vapor etch etches high aspect ratio openings to form MEMS devices and other tightly-packed semiconductor devices with 0.2 μm air gaps between structures. The HF vapor etch etches oxide plugs and gaps with void portions and oxide liner portions and further etches oxide layers that are buried beneath silicon and other structures and is ideally suited to release cantilevers and other MEMS devices. The HF vapor etches at room temperature and atmospheric pressure in one embodiment. A process sequence is provided that forms MEMS devices including cantilevers and lateral, in-plane electrodes that are stationary and vibration resistant. | 2013-09-05 |
20130230940 | ETCH-RESISTANT COMPOSITION AND ITS APPLICATION - An etch-resistant composition is provided. The etch-resistant composition comprises a polymer and a first organic solvent. The polymer is prepared by copolymerizing a polymerization unit comprising styrene-based monomer(s) and acrylate-based monomer(s), and has a weight average molecular weight of at least about 35,000. Based on the total weight of the etch-resistant composition, the amount of the polymer is about 20.0 to about 60.0 wt % and the amount of the solvent is about 40.0 to about 80.0 wt %. The etch-resistant composition can be used for preparing a selective emitter of a solar cell. | 2013-09-05 |
20130230941 | Implanting Method for Forming Photodiode - An implanting method for forming a photodiode comprises providing a substrate with a first conductivity, growing an epitaxial layer on the substrate, implanting ions with a second conductivity in the epitaxial layer from a front side of the substrate and implanting ions with the first conductivity in the epitaxial layer from the front side of the substrate to form a photo active region adjacent to the front side and a photo inactive region underneath the photo active region. By employing the implanting method, an average doping density of the photo active region is approximately ten times more than an average doping density of the photo inactive region. | 2013-09-05 |
20130230942 | Organic Photovoltaic Device with Ferroelectric Dipole and Method of Making Same - A method of fabricating an organic photovoltaic device. The method includes providing a first electrode which by applying a layer of conductive material onto a transparent substrate. The conductive material forms the first electrode. The method also includes placing an active layer of organic photovoltaic material on top of the first electrode. The active layer is configured to convert photonic energy into electrical energy. Placing an active layer of organic photovoltaic material includes placing an active layer of organic photovoltaic material having ferroelectric dipoles dispersed therein. The method further includes applying a second electrode on top of the active layer of organic photovoltaic material. | 2013-09-05 |
20130230943 | SOLAR CELL DEVICE AND SOLAR CELL DEVICE MANUFACTURING METHOD - A solar cell device is formed of an insulating layer provided metal substrate and a photoelectric conversion circuit, which includes a photoelectric conversion layer, an upper electrode, and a lower electrode, formed on the substrate. The substrate is constituted by a metal substrate and a porous Al anodized film. The metal substrate is formed of a base material of a metal having a higher rigidity, a high heat resistance, and a smaller linear thermal expansion coefficient than Al and an Al material integrated by pressure bonding to at least one surface thereof, and the porous Al anodized film is formed on a surface of the Al material. | 2013-09-05 |
20130230944 | DOPING AN ABSORBER LAYER OF A PHOTOVOLTAIC DEVICE VIA DIFFUSION FROM A WINDOW LAYER - Methods for doping an absorbent layer of a p-n heterojunction in a thin film photovoltaic device are provided. The method can include depositing a window layer on a transparent substrate, where the window layer includes at least one dopant (e.g., copper). A p-n heterojunction can be formed on the window layer, with the p-n heterojunction including a photovoltaic material (e.g., cadmium telluride) in an absorber layer. The dopant can then be diffused from the window layer into the absorber layer (e.g., via annealing). | 2013-09-05 |
20130230945 | METHOD AND APPARATUS FOR FORMING A TRANSPARENT CONDUCTIVE OXIDE USING HYDROGEN - A method and apparatus for forming a crystalline cadmium stannate layer of a photovoltaic device by heating an amorphous layer in the presence of hydrogen gas. | 2013-09-05 |
20130230946 | BACKSIDE MOLD PROCESS FOR ULTRA THIN SUBSTRATE AND PACKAGE ON PACKAGE ASSEMBLY - In some embodiments, selective electroless plating for electronic substrates is presented. In this regard, a method is introduced including receiving a coreless substrate strip, forming a stiffening mold on a backside of the coreless substrate strip adjacent to sites where solder balls are to be attached, and attaching solder balls to the backside of the coreless substrate strip amongst the stiffening mold. Other embodiments are also disclosed and claimed. | 2013-09-05 |
20130230947 | FABRICATION METHOD OF PACKAGE STRUCTURE HAVING EMBEDDED SEMICONDUCTOR COMPONENT - A package structure having an embedded semiconductor component, includes: a chip having an active surface with electrode pads and an inactive surface opposite to the active surface; a first insulating protection layer having a chip mounting area for the chip to be mounted thereon via the active surface thereof; a plurality of connection columns disposed in the first insulating protection layer at positions corresponding to the electrode pads and electrically connected to the electrode pads via solder bumps; an encapsulant formed on one surface of the first insulating protection layer having the chip mounted thereon for encapsulating the chip; and a built-up structure formed on the other surface of the first insulating protection layer and the connection columns. Due to the bending resistance of the encapsulant, the warpage of the built-up structure is prevented. | 2013-09-05 |
20130230948 | MULTIPLE STEP IMPLANT PROCESS FOR FORMING SOURCE/DRAIN REGIONS ON SEMICONDUCTOR DEVICES - Disclosed herein is a multiple step implantation process to form source/drain regions in semiconductor devices. In one example, the method involves performing an extension implant process to form extension implant regions in a semiconducting substrate comprising a buried insulation layer, forming a patterned mask layer above the substrate and performing at least two source/drain ion implant processes through the patterned mask layer to form doped source/drain implant regions in the substrate, wherein one of the at least two source/drain ion implant processes is performed with a dopant dose that is less than a dopant dose used in another of the at least two source/drain ion implant processes. In further embodiments, one of the at least two source/drain ion implant processes is performed at an implant energy level that is greater than an implant energy level used in another of the at least two source/drain ion implantation processes. | 2013-09-05 |
20130230949 | EMBEDDED DRAM FOR EXTREMELY THIN SEMICONDUCTOR-ON-INSULATOR - A node dielectric and a conductive trench fill region filling a deep trench are recessed to a depth that is substantially coplanar with a top surface of a semiconductor-on-insulator (SOI) layer. A shallow trench isolation portion is formed on one side of an upper portion of the deep trench, while the other side of the upper portion of the deep trench provides an exposed surface of a semiconductor material of the conductive fill region. A selective epitaxy process is performed to deposit a raised source region and a raised strap region. The raised source region is formed directly on a planar source region within the SOI layer, and the raised strap region is formed directly on the conductive fill region. The raised strap region contacts the raised source region to provide an electrically conductive path between the planar source region and the conductive fill region. | 2013-09-05 |
20130230950 | MASK AND METHOD OF MANUFACTURING ARRAY SUBSTRATE USING THE SAME - A mask includes: a substrate that includes a central area and a peripheral area disposed around the central area; and lenses disposed in rows and columns, in the central area and the peripheral area. The lenses of opposing sides of the peripheral area may be disposed in different rows or columns. For a given amount of input light, the lenses of the peripheral area may focus less light on a substrate than the lenses of the central area. The mask may be disposed over the substrate in different positions, and then the substrate may be irradiated through the mask, while the mask is in each of the positions. The peripheral portion of the mask may be disposed over the same area of the substrate, while the mask is in different ones of the positions. | 2013-09-05 |
20130230951 | ASYMMETRICALLY RECESSED HIGH-POWER AND HIGH-GAIN ULTRA-SHORT GATE HEMT DEVICE - A high-power and high-gain ultra-short gate HEMT device has exceptional gain and an exceptionally high breakdown voltage provided by an increased width asymmetric recess for the gate electrode, by a composite channel layer including a thin indium arsenide layer embedded in the indium gallium arsenide channel layer and by double doping through the use of an additional silicon doping spike. The improved transistor has an exceptional 14 dB gain at 110 GHz and exhibits an exceptionally high 3.5-4 V breakdown voltage, thus to provide high gain, high-power and ultra-high frequency in an ultra-short gate device. | 2013-09-05 |
20130230952 | INTEGRATED CIRCUIT DEVICE AND METHOD OF MANUFACTURING SAME - An integrated circuit device and method for manufacturing the integrated circuit device is disclosed. The disclosed method provides improved protection for the bottom portion of the gate structure. In some embodiments, the method achieves improved protection for gate structure bottom by forming a recess on either side of the gate structure and placing spacers on the side walls of the gate structure, so that the spacers protect the portion of the gate structure below the gate dielectric layer. | 2013-09-05 |
20130230953 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - According to one embodiment, a method for manufacturing a semiconductor device, includes preparing a structure body. In the structure body, a fin extending in a first direction is formed on an upper surface of a semiconductor substrate, a lower-side mask member is provided on the fin, and an upper-side mask member that is wider than the fin and the lower-side mask member is provided on the lower-side mask member. The method includes implanting an impurity into the semiconductor substrate with the upper-side mask member and the lower-side mask member as a mask, removing the upper-side mask member, forming a gate insulator film on a side surface of the fin, forming a conductive film that covers the fin and the lower-side mask member, forming a mask for gate having a pattern extending in a second direction, and removing selectively the conductive film to form a gate electrode. | 2013-09-05 |
20130230954 | TUNNELING FIELD-EFFECT TRANSISTOR WITH DIRECT TUNNELING FOR ENHANCED TUNNELING CURRENT - Horizontal and vertical tunneling field-effect transistors (TFETs) having an abrupt junction between source and drain regions increases probability of direct tunneling of carriers (e.g., electrons and holes). The increased probability allows a higher achievable on current in TFETs having the abrupt junction. The abrupt junction may be formed by placement of a dielectric layer or a dielectric layer and a semiconductor layer in a current path between the source and drain regions. The dielectric layer may be a low permittivity oxide such as silicon oxide, lanthanum oxide, zirconium oxide, or aluminum oxide. | 2013-09-05 |
20130230955 | METHOD FOR FABRICATING A VERTICAL TRANSISTOR - A method for fabricating a vertical transistor comprises steps: forming a plurality of first trenches in a substrate; sequentially epitaxially growing a first polarity layer and a channel layer inside the first trenches, and forming a first retard layer on the channel layer; etching the first retard layer and the channel layer along the direction vertical to the first trenches to form a plurality of pillars; respectively forming a gate on a first sidewall and a second sidewall of each pillar; removing the first retard layer on the pillar; and epitaxially growing a second polarity layer on the pillar. The present invention is characterized by using an epitaxial method to form the first polarity layer, the channel layer and the second polarity layer and has the advantage of uniform ion concentration distribution. Therefore, the present invention can fabricate a high-quality vertical transistor. | 2013-09-05 |
20130230956 | Trench Electrode Arrangement - A method includes forming a trench extending from a first surface of a semiconductor body into the semiconductor body such that a first trench section and at least one second trench section adjoin the first trench section, wherein the first trench section is wider than the second trench section. A first electrode is formed, in the at least one second trench section, and dielectrically insulated from semiconductor regions of the semiconductor body by a first dielectric layer. An inter-electrode dielectric layer is formed, in the at least one second trench section, on the first electrode. A second electrode is formed, in the at least one second trench section on the inter-electrode dielectric layer, and in the first trench section, such that the second electrode at least in the first trench section is dielectrically insulated from the semiconductor body by a second dielectric layer. | 2013-09-05 |
20130230957 | Methods of Forming Field Effect Transistors on Substrates - The invention includes methods of forming field effect transistors. In one implementation, the invention encompasses a method of forming a field effect transistor on a substrate, where the field effect transistor comprises a pair of conductively doped source/drain regions, a channel region received intermediate the pair of source/drain regions, and a transistor gate received operably proximate the channel region. Such implementation includes conducting a dopant activation anneal of the pair of source/drain regions prior to depositing material from which a conductive portion of the transistor gate is made. Other aspects and implementations are contemplated. | 2013-09-05 |
20130230958 | Multiple-Gate Semiconductor Device and Method - A system and method for manufacturing multiple-gate semiconductor devices is disclosed. An embodiment comprises multiple fins, wherein intra-fin isolation regions extend into the substrate less than inter-fin isolation regions. Regions of the multiple fins not covered by the gate stack are removed and source/drain regions are formed from the substrate so as to avoid the formation of voids between the fins in the source/drain region. | 2013-09-05 |