35th week of 2012 patent applcation highlights part 45 |
Patent application number | Title | Published |
20120220734 | Reversible Fluorescence Photoswitch based on Dye-Crosslinked Dendritic Nanoclusters for High-Contrast Imaging of Living Biological Systems - The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications. | 2012-08-30 |
20120220735 | HIGH MOLECULAR WEIGHT POLYESTER POLYMERS WITH REDUCED ACETALDEHYDE - Polyester compositions, especially polyethylene terephthalate homopolymer and copolymers, are disclosed containing titanium catalysts and catalyst deactivator added late in the manufacturing processing having reduced acetaldehyde generation rates. The polyester compositions are low in free acetaldehyde, making them suitable for fabrication into beverage containers for relatively tasteless beverages such as bottle water. Furthermore, the polyesters are polymerized to a high inherent viscosity in reduced processing time, without the necessity of further polymerization in the solid state, and in the absence of acetaldehyde scavengers leading to polyester polymers having reduced color. | 2012-08-30 |
20120220736 | ALDIMINES AND COMPOSITIONS COMPRISING ALDIMINE - Aldimino containing compounds obtained from a reaction of aldimines of formula (I) with a compound that bears at least one reactive group that can enter into addition reactions with an HX group of an aldimine of formula I. The compounds containing aldimine groups can be used primarily in adhesive and sealant materials, but also in coatings, and can be produced easily from readily available source materials, and have good thermal stability. The tertiary amino group thereof has a surprisingly low alkalinity and can in some cases have a catalytic effect in chemical reaction systems. | 2012-08-30 |
20120220737 | POLYCARBONATE RESIN COMPOSITION - To provide a polycarbonate resin composition having a high Abbe's number, high strength and excellent stainability. | 2012-08-30 |
20120220738 | HIGH PRESSURE LDPE FOR MEDICAL APPLICATIONS - A novel LDPE from radical, high pressure polymerization is devised. | 2012-08-30 |
20120220739 | Catalyst for the Polymerization of Olefins - The present invention relates to catalysts systems for the polymerization of ethylene and its mixtures with olefins CH | 2012-08-30 |
20120220740 | POLYMERIC ACID CATALYSTS AND USES THEREOF - Polymers useful as catalysts in non-enzymatic saccharification processes are provided. Provided are also methods for hydrolyzing cellulosic materials into monosaccharides and/or oligosaccharides using these polymeric acid catalysts. | 2012-08-30 |
20120220741 | POLYVINYLAMIDE POLYMERS CONTAINING POLYMERIZABLE FUNCTIONALITIES - The present invention relates to a polymerizable polymer formed from an N-vinyl amide monomer and containing a polymerizable functionality. In one approach, a dual functional monomer may be employed. In the case where the dual functional monomer incorporates glycidyl methacrylate, a third polymerizable monomer is also included. In a second approach, a monomer with polymerizable functionality can be grafted onto a pre-existing, suitable N-vinyl amide co-polymeric material, yielding a co-polymer comprising a polymerizable functionality. | 2012-08-30 |
20120220742 | Furan-Based Curable Compound Derived from Biomass, Solvent-Free Curable Composition, and Method for Preparing Same - The present invention relates to a furan-based curable compound derived from carbohydrate-based biomass, to a solvent-free curable composition, and to a method for preparing thereof, wherein the furan-based curable compound derived from biomass according to the present invention includes two epoxide functional groups bonded to at least one furan-based compound. The present invention may provide an environmentally friendly next-generation curable compound comprising a novel furan-based compound derived from biomass, which may be substituted for curable materials derived from oil resources, as a basic backbone, as well as a composition containing the same. According to the present invention, a curable material, which has a low contraction ratio during curing as compared to conventional radical-type curing materials, may be obtained, and a compound applied to the novel curing material may be prepared with a combination of excellent efficiency and cost-effectiveness. | 2012-08-30 |
20120220743 | Dimensionally Stable Silicone Hydrogel Contact Lenses - Dimensionally stable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): | 2012-08-30 |
20120220744 | Wettable Silicone Hydrogel Contact Lenses - Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. | 2012-08-30 |
20120220745 | PRODUCTION METHOD FOR WATER-ABSORBING RESIN POWDER | 2012-08-30 |
20120220746 | PROCESS FOR PRODUCING THERMOPLASTIC RESIN MOLDED PRODUCT AND THERMOPLASTIC RESIN PARTICLE COMPOSITION - A process for producing a thermoplastic resin molded product, comprising: a placement step of placing a thermoplastic resin particle composition | 2012-08-30 |
20120220747 | BIMODAL POLYETHYLENE COMPOSITIONS FOR BLOW MOLDING APPLICATIONS - Bimodal polyethylene compositions and methods for making the same are provided. In at least one specific embodiment, the bimodal polyethylene composition can include a high molecular weight component having a weight average molecular weight (Mw) of from about 400,000 to about 950,000. The bimodal polyethylene composition can also include a low molecular weight component having a weight average molecular weight (Mw) of from about 3,000 to about 100,000. The high molecular weight component can be present in an amount ranging from about 25 wt % to about 40 wt % of the bimodal polyethylene composition. The bimodal polyethylene composition can also have a percent die swell of less than about 80%. | 2012-08-30 |
20120220748 | FIVE-RING FUSED HETEROAROMATIC COMPOUNDS AND CONJUGATED POLYMERS THEREOF - Compounds having a core comprised of an aromatic ring and at least two annulated beta-substituted fused thiophene ring systems of the general formula: | 2012-08-30 |
20120220749 | COMBINATIORIAL POLYMERIC COMPOSITIONS FOR DRUG DELIVERY - The present invention is directed towards the synthesis of polymeric drug delivery compositions which would address some of the important and difficult to realize aspects of polymer based drug delivery systems by being, biocompatible, stable, capable of achieving desired drug loading, and safe from accidental release while being non-toxic, easy to fabricate and safe for the environment. | 2012-08-30 |
20120220750 | HYDROXYL-FUNCTIONAL POLYESTER RESINS - A hydroxyl-functional polyester resin composition including the reaction product of (a) a divinylarene dioxide, and (b) at least one dicarboxylic acid; a process for making the hydroxyl-functional polyester resin composition; and a curable hydroxyl-functional polyester resin composition made therefrom. The cured product made from the above curable hydroxyl-functional polyester resin composition is thermally stable and offers improved properties such as a lower viscosity and a high heat resistance compared to known cured products prepared from known epoxy resins. | 2012-08-30 |
20120220751 | Non-Fluorescent Quencher Compounds and Biomolecular Assays - Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides and polypeptides. The quencher moieties are non-fluorescent and accept energy transfer from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. | 2012-08-30 |
20120220752 | TRI-AMINO RELEASING FULVATE - A free amino acid and/or amino ion-releasing molecule useful for a wide variety of medical and cosmetic applications. The chemical name of the new molecule nino-gl ino-parabenzoate, sometimes referred to herein as TAFA. Its chemical structure is graphically depicted according to structure VIII | 2012-08-30 |
20120220753 | N-Terminal Dimerization Methods with Bis-Amindino Acid and Bis-Thioimidate Derivatives - The invention provides high-yield protein dimerization methods using highly reactive bis-thioimidates that may be used in the manufacture of a highly potent anti-cancer peptide dimers. | 2012-08-30 |
20120220754 | METHODS FOR GENERATING RADIOIMMUNOCONJUGATES - Methods for generating an Ac-225 radioconjugate comprising a monoclonal antibody (mAb) (IgG) is disclosed. The Ac-225 radioimmunoconjugate is an [Ac-225]-p-SCN-Bn-DOT AIHuM195 radioimmunoconjugate. | 2012-08-30 |
20120220755 | ORGANIC CATION TRANSPORTER POLYPEPTIDES - Novel genes significantly homologous to organic cation transporters OCT1 and OCT2 have been successfully isolated by screening a fetal gene library by random sequencing. Proteins encoded by these genes function as transporters of various organic cations. | 2012-08-30 |
20120220756 | Novel Brazzein Variant Having Higher Sweetness and Method for Preparing Multi-Variant - Novel brazzein variants having higher sweetness and the use thereof are provided. The brazzein variants or multi-variants have higher sweetness than a wild-type brazzein protein. Also, a method of preparing the brazzein variants and a food composition for enhancing a sugar content including the same are provided. The brazzein variants or multi-variants have higher sweetness at least twice that of a conventional brazzein protein, and show equivalent properties such as thermal and pH stabilities and high water solubility compared to the conventional brazzein protein. Therefore, a smaller amount of brazzein variants can be used together with a greater amount of other sweeteners such as sucrose, and can be replaced with the other sweeteners. So, the brazzein variants can be widely used as an additive in manufacture of food products. | 2012-08-30 |
20120220757 | NOVEL CARBAMYLATED EPO AND METHOD FOR ITS PRODUCTION - The present invention discloses a method for production of novel carbamylated erythropoietin and compositions comprising the novel carbamylated erythropoietin and pharmaceutical compositions comprising this and uses thereof. | 2012-08-30 |
20120220758 | ANTIBODY HAVING ACTIVITY OF INHIBITING HEPATITIS C VIRUS (HCV) INFECTION AND USE THEREOF - An object of the present invention is to provide an antibody inhibiting infection with hepatitis C virus (HCV). The present invention provides an anti-hepatitis C virus antibody that recognizes a whole or a part of the conformation of a hepatitis C virus particle as an epitope and binds thereto, so as to be able to inhibit the binding of hepatitis C virus to the surface of a host cell and to inhibit HCV infection, a humanized antibody thereof, and an inhibitory agent for infection with hepatitis C virus. | 2012-08-30 |
20120220759 | SYNTHETIC HEPARIN DISACCHARIDES - Preparation and use of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids. | 2012-08-30 |
20120220760 | COMPOSITION COMPRISING RNA DERIVED FROM LACTIC ACID BACTERIUM AS EFFECTIVE COMPONENT - A composition has an immunomodulation action, and comprises an RNA derived from a lactic acid bacterium as an effective component. Alternatively, a composition has a cytokine production-modulating action, and includes an RNA derived from a lactic acid bacterium as an effective component. | 2012-08-30 |
20120220761 | PROCESS FOR TRIPHOSPHATE OLIGONUCLEOTIDE SYNTHESIS - The present invention describes simple, efficient, and enzyme-free method of making oligonucleotides with 5′-triphosphate. This invention presents novel process for synthesizing triphosphate oligonucleotides using a diaryl phosphonate as reagent. The process of the present invention is amenable to large-scale, economic 5′-triphosphate oligonucleotide synthesis. | 2012-08-30 |
20120220762 | METHOD FOR THE MANUFACTURE OF 2-FLUORO-ARA-ADENINE - A method is described for the manufacture of pure 2-fluoro-ara-adenine of Formula (I) from 2-fluoro-ara-adenine triacetate using potassium carbonate (K | 2012-08-30 |
20120220763 | Methods for Extraction and Purification of Gangliosides - Methods for purification and extraction of GM1 ganglioside from cells derived from sheep afflicted with GM1 gangliosidosis or from cells derived from human patients with GM1 gangliosidosis as stable and renewable sources of GM1. | 2012-08-30 |
20120220764 | METHOD FOR PRODUCING A CRYSTALLINE TABLETING ADDITIVE, ADDITIVE THUS OBTAINED AND USE THEREOF - A method for producing a tableting additive, which method comprises providing a spray dried tableting additive in particulate form which particles at leas partially consist of amorphous additive material and at least partially of crystalline additive material; and crystallising the amorphous additive material by subjecting the particles for a short time and under agitation to a temperature between 30 and 100° C. at a relative humidity between 60 and 25%. More in particular, the relationship between relative humidity and temperature is defined by the formula: % relative humidity=218-47*Ln(T(° C.)), wherein T(° C.) is the temperature to which the particles are subjected. | 2012-08-30 |
20120220765 | BETA-LACTAMYL PHENYLALANINE, CYSTEINE, AND SERINE VASOPRESSIN ANTAGONISTS - Substituted 2-(azetidin-2-on-1-yl)alkoxyalkylalkanoic acids and 2-(azetidin-2-on-1-yl)arylalkylalkanoic acids, and analogs and derivatives thereof are described. Methods for using the described compounds, and pharmaceutical compositions thereof, to treat disease states responsive to antagonism of one or more vasopressin receptors are also described. | 2012-08-30 |
20120220766 | TETRAHYDRO-IMIDAZO[1,5-alpha] PYRAZINE DERIVATIVES, PREPERATION PROCESS AND MEDICINAL USE THEREOF - Tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I), their preparation methods, pharmaceutical compositions containing the derivatives and uses thereof as medicaments, especially as dipeptidyl peptidase IV inhibitors, wherein the substituents of formula (I) are defined as same as the description. | 2012-08-30 |
20120220767 | AMINOTHIAZOLE DERIVATIVE - A compound represented by formula (1) or a pharmaceutically acceptable salt thereof, which has a PI3 kinase γ inhibitory effect and is useful as a prophylactic or therapeutic agent for articular rheumatism, Crohn's disease, irritable colitis, Sjoegren's syndrome, multiple sclerosis, systemic lupus erythematosus, asthma, atopic dermatitis, arteriosclerosis, organ transplant rejection, cancer, retinopathy, psoriasis, arthrosis deformans, age-related macular degeneration, type II diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hyperlipemia, etc. | 2012-08-30 |
20120220768 | PROCESS OF FORMING AN AMIDE - A process is provided for the synthesis of an amide. A primary or secondary amine and a primary alcohol, with the amine and the alcohol being either moieties of different reactants or moieties of the same molecule, are contacted in the presence of a Ruthenium (II) catalyst. The Ruthenium (II) catalyst is free of a phosphine ligand. The process is also carried out in the absence of a phosphine. Providing the Ruthenium (II) catalyst includes providing an N-heterocyclic carbene. | 2012-08-30 |
20120220769 | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE - A process for preparing 7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7H-pyrazolo-[4,3-e]-[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, intermediates useful in that process, and processes for preparing said intermediates are disclosed. | 2012-08-30 |
20120220770 | PREPARATION OF BICYCLIC GUANIDINE SALTS IN AN AQUEOUS MEDIA - Disclosed herein are bicyclic guanidine salts formed as the reaction product of reactants comprising (a) a compound having the general formula CX | 2012-08-30 |
20120220771 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES - The invention relates to a process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides and to the useful intermediate compounds of such process. The process allows to obtain the desired products in high yields and purity. The synthesis is starting from the coupling of an acetal with a beta-ketoester; the resultant compound is acetylated and then reacted with a dialkyl acetal of N,N-dimethylformamide to give an intermediate which is cyclized to 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxylic ester; the carboxylic ester is then hydrolyzed and the resultant carboxylic acid is finally condensed with an appropriate form of ammonia to give the desired carboxamide. The compounds prepared according to the process of the invention are endowed with protein kinase inhibiting activity and, more particularly, Cdc7 or Cdc7/Cdks inhibiting activity. The compounds are useful in the treatment of a variety of cancers, cell proliferative disorders and diseases associated with protein kinases. | 2012-08-30 |
20120220772 | NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE | 2012-08-30 |
20120220773 | PYRIDINE CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE - Disclosed are compounds of the formula I: | 2012-08-30 |
20120220774 | Process for Synthesizing Substituted Isoquinolines - The present disclosure generally relates to a process for synthesizing optionally substituted 1-chloro-4-methoxyisoquinolines. The present disclosure also relates to intermediates useful in this process. | 2012-08-30 |
20120220775 | ENANTIOSELECTIVE PREPARATION OF QUINOLINE DERIVATIVES - A process for preparing 8-substituted oxy-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(α-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula I or II | 2012-08-30 |
20120220776 | PROCESS FOR THE PREPARATION OF ILOPERIDONE USING A NOVEL INTERMEDIATE - The present invention provides a novel process for the preparation of iloperidone using a novel intermediate. Thus, for example, 4-(3-chloropropoxy)-3-methoxybenzaldehyde is reacted with methyl magnesium iodide in ether and the reaction mass is heated for 6 hours at reflux temperature, the resulting mass is cooled to ambient temperature and then poured into a mixture of ice, water and dilute hydrochloric acid to produce 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanol, which is then subsequently converted to iloperidone. | 2012-08-30 |
20120220777 | PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM OF LENALIDOMIDE - The present invention relates to an in-situ process for the preparation of polymorphic Form A of lenalidomide. | 2012-08-30 |
20120220778 | Process for the synthesis of naratriptan - The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR | 2012-08-30 |
20120220779 | Novel Processes - The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided. | 2012-08-30 |
20120220780 | LIGAND FOR ASYMMETRIC SYNTHESIS CATALYST, AND PROCESS FOR PRODUCTION OF ALPHA-ALKENYL CYCLIC COMPOUND USING SAME - Disclosed are: a ligand for an asymmetric synthesis catalyst; and a process for producing an α-alkenyl cyclic compound using the ligand. Specifically disclosed are: a ligand for an asymmetric synthesis catalyst, which is represented by any one of formulae (1) to (4) [wherein R | 2012-08-30 |
20120220781 | Process for preparing 1,3-disubstituted pyrazole compounds - A process for preparing 1,3-disubstituted pyrazole compounds. | 2012-08-30 |
20120220782 | SYNTHESIS OF AMINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF - The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, | 2012-08-30 |
20120220783 | SALTS OF SUNITINIB - The present invention relates to salts of sunitinib and their preparation. | 2012-08-30 |
20120220784 | PROCESS FOR REDUCTION OF ALPHA-ACYLOXY SULFIDE DERIVATIVES - The present invention provides an efficient and scalable process to prepare the compound of formula 4 by reduction of the corresponding α-acyloxy sulfides. | 2012-08-30 |
20120220785 | SULTONE COMPOUND DERIVATIVES SUBSTITUTED BY NUCLEOPHILES, IN PARTICULAR RADIONUCLIDES, AND USE THEREOF FOR MARKING MACROMOLECULES - The invention relates to polysultone derivatives used as precursors to radiolabelled macromolecules usable for medicine and in nuclear imaging. The aim of the invention is to provide novel prosthetic compounds or groupings, the synthesis of which is straightforward, easy and automatable, enabling access to economical and effective radiolabelled macromolecules. The aim is achieved by the invention, which involves compounds of formula 10 or 11. Said double-sultone derivatives are produced by opening the sultone rings using a nucleophile radical R | 2012-08-30 |
20120220786 | PROCESS FOR THE PREPARATION OF FOSAMPRENAVIR CALCIUM - The present invention relates to process for the preparation of fosamprenavir calcium. | 2012-08-30 |
20120220787 | PROCESS FOR THE PREPARATION OF 5-/6-NITROFLUORESCEIN - A process for the preparation of a mixture of 3′,6′-dihydroxy-6-nitrospiro[2-benzofuran-3,9′-xanthene]-1-one and 3′,6′-dihydroxy-5-nitrospiro[2-benzofuran-3,9′- xanthene]-1-one comprising the steps of:- (a) reacting 4-nitrophthalic acid or 4-nitrophthalic anhydride with benzene-1,3-diol in methanesulphonic acid; (b) quenching the reaction in step (a) with a solvent to precipitate product; (c) isolating the precipitate; (d) heating the precipitate in water in order to hydrolyse any methansulphonic acid ester present. | 2012-08-30 |
20120220788 | Continuous preparation of carbonates - A process for the manufacture of fluoroethylene carbonate or difluoroethylene carbonate by reaction of ethylene carbonate and F | 2012-08-30 |
20120220789 | POLYPHENOL DERIVATIVE AND METHOD FOR PRODUCING THE SAME - A novel substance exhibiting physiologically active effects is produced from a tea leaf. A novel polyphenol derivative is produced, for example, by subjecting a microbially fermented tea leaf obtained by culturing | 2012-08-30 |
20120220790 | CYCLOPARA (HETERO) ARYLENE COMPOUND AND METHOD FOR PRODUCING SAME - Provided are a cyclopara(hetero)arylene compound and a method for producing the same. More specifically, provided is a cycloparaphenylene compound represented by Formula (I): | 2012-08-30 |
20120220791 | COPOLYMERS OF EPOXY COMPOUNDS AND AMINO SILANES - A composition includes a non-crosslinked reaction product of an oxirane or oxetane compound (I) comprising at least two oxirane or oxetane groups; a compound (II) comprising silicon and one or more amino groups; and optionally a polyamine (III); and a secondary amine (IV). | 2012-08-30 |
20120220792 | PROCESS FOR PRODUCING ALDEHYDES OR KETONES BY OXIDIZING ALCOHOLS WITH OXYGEN - Provided is a process for producing aldehydes or ketones by oxidizing alcohols with oxygen, which comprises oxidizing alcohols to aldehydes or ketones in an organic solvent at room temperature with oxygen or air as an oxidant, wherein ferric nitrate (Fe(NO3)3.9H2O), 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) and an inorganic chloride are used as catalysts, the reaction time is 1-24 hours, and the molar ratio of said alcohols, 2,2,6,6-tetramethylpiperidine N-oxyl and the inorganic chloride is 100:1˜10:1˜10:1˜10. The present process has the advantages of high yield, mild reaction conditions, simple operation, convenient separation and purification, recoverable solvents, substrates used therefor being various and no pollution, and therefore it is adaptable to industrialization. | 2012-08-30 |
20120220793 | Method for Producing (Hydroxymethyl)Polysiloxanes - A method for producing (hydroxymethyl)polysiloxanes of the general formula I | 2012-08-30 |
20120220794 | PROCESS FOR HYDROGENATION OF HALOGENOALKENES WITHOUT DEHALOGENATION - The present invention relates in general to the field of organic chemistry and in particular to the preparation of halogenoalkanes. | 2012-08-30 |
20120220795 | METHOD FOR PRODUCING AROMATIC DIFLUOROACETIC ACID ESTER - Disclosed is a method for producing a compound having a difluoromethylene group at an even lower cost and with excellent yield. The production method of the present invention is a method for producing an aromatic difluoroacetic acid ester, which comprises reacting an iodobenzene containing an electro attracting group and an α-silyl difluoroacetic acid ester in the presence of a metal halide. | 2012-08-30 |
20120220796 | CATALYTIC DEHYDRATION OF ALCOHOLS USING NON-VOLATILE ACID CATALYSTS - A catalytic process for dehydration of an aliphatic C | 2012-08-30 |
20120220797 | PROCESS FOR OBTAINING 3, 3-DIPHENYLPROPYLAMINES - The invention relates to a process for obtaining 3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, comprising a chemoselective reduction of the acid group against the ester group in compounds of general formula (V), wherein R | 2012-08-30 |
20120220798 | METHOD FOR CARBOXYLIC ACID ESTERIFICATION - The present invention relates to a method for esterification from alcohols and carboxylic acids using a heterogeneous catalyst, wherein the esterification reaction is performed at high temperatures enabling an improvement in the compromise between selectivity, conversion, and kinetics in various types of devices for implementing the method. | 2012-08-30 |
20120220799 | NOVEL PROCESS - The present invention relates to a novel process for the preparation of γ-amino acids, such as (±)-3-(aminomethyl)-5-methyl-hexanoic acid 1, which is a key intermediate in the preparation of the potent anticonvulsant pregabalin, (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid 2. | 2012-08-30 |
20120220800 | Process and Apparatus for Manufacturing Pure Forms of Aromatic Carboxylic Acids - A process and apparatus for manufacture of aromatic carboxylic acids comprises a liquid phase oxidation of aromatic hydrocarbon feed materials and treatment of a high pressure off-gas from the liquid phase oxidation to separate water and reaction solvent and purification of impure aromatic carboxylic acid products wherein a purification liquid includes water from off-gas treatment. | 2012-08-30 |
20120220801 | ACETIC ACID PRODUCTION PROCESS - A method for determining the characteristic of one or more components in a step of an acetic acid production process using Raman spectroscopy. The process includes providing a feed stream comprising multiple components to a separations unit, one of the components being acetic acid, the separations unit separating the feed stream into two or more exit streams having a different composition from one another, and measuring a characteristic of one or more of the components by Raman spectroscopic analysis. | 2012-08-30 |
20120220802 | INSECTICIDE FOR AGRICULTURAL OR HORTICULTURAL USE AND METHOD OF USE THEREOF - Aniline derivatives represented by formula (8) and formula (9): | 2012-08-30 |
20120220803 | Process for Production of Trialkylphosphine - A production process of a trialkylphosphine according to the present invention includes: a first step of forming a trialkylphosphine by reaction of an organic metal compound and an organic phosphorous compound in an ether solvent having a difference in boiling point with the trialkylphosphine formed such that the difference in boiling point is in a range of 0° C. to 20° C.; a second step of obtaining a silver complex by absorption of a gas phase of the first step into an aqueous solution of AgI and KI; a third step of heating the silver complex obtained in the second step, in a metallic reaction vessel, at a temperature of 170° C. to 350° C. in a reduced pressure atmosphere of 1.333×10 | 2012-08-30 |
20120220804 | MANUFACTURE OF DIMETHYL ETHER FROM CRUDE METHANOL - A method of producing dimethyl ether by catalytic dehydration of crude methanol as feedstock in the gas phase includes providing the crude methanol from methanol synthesis, where the crude methanol having a total content of carbonyl compounds of not more than 100 wt-ppm, calculated, as mass equivalents of acetone. The crude methanol is evaporated, and the reaction temperature and reaction pressure are adjusted. A reactor filled with dehydration catalyst is charged with the evaporated crude methanol with a defined space velocity. A gaseous product mixture comprising dimethyl ether, non-reacted methanol and water is discharged. Cooling, partial condensation and separation of the gaseous product mixture are carried out so as to provide gaseous dimethyl ether, liquid water and methanol as products, and the methanol is recirculated. | 2012-08-30 |
20120220805 | NOVEL TRISPHENOL COMPUND - A trisphenol compound is expressed by formula (1), wherein R represents an alkyl group or alkoxyl group with 1 to 8 carbon atoms, phenyl group or hydroxyl group; R | 2012-08-30 |
20120220806 | Method For Producing Guerbet Alcohols - The invention relates to a method for the dimerization of alcohols in the context of a Guerbet reaction, in which one or more alcohols (A) having 2 to 72 C atoms and 1 to 3 OH groups per molecule are reacted in the presence of (a) a base (B), (b) a carbonyl compound (C), and (c) a hydrogenation catalyst (H) from the group of metals ruthenium, rhodium, palladium, osmium, iridium, and platinum, said metals being in the elementary form, with the proviso that the alcohols (A) have at least one primary or secondary OH group, and that a C atom that carries at least one H atom as a substituent is directly adjacent to the C atom with said primary or secondary OH group. | 2012-08-30 |
20120220807 | a-OLEFIN / VINYL PYRROLIDINONE COPOLYMERS AS ASPHALTENE DISPERSANTS - An additive comprising, dissolved in a solvent, an asphaltene dispersant selected from the group consisting of α-olefin/vinyl pyrrolidinone copolymers. The copolymer can comprise at least one α-olefin selected from the group consisting of mono-α-olefins, at least one α-olefin selected from the group consisting of linear α-olefins and/or at least one α-olefin is selected from the group consisting of 1-hexadecene, 1-octadecene, 1-eicosene, 1-docosene, 1-tetracosene, 1-hexacosene, 1-octacosene and 1-triacontene. The additive can comprise a copolymer of 2-pyrrolidinone, 1-ethenyl monomer. The copolymer can have a Hansen Solubility Parameter (HSP), δ, of greater than 16, 17 or 18 MPa | 2012-08-30 |
20120220808 | METHOD FOR MANUFACTURING OLEFINS - The present invention relates to a process for producing an olefin, including the step of subjecting an aliphatic primary alcohol having 12 to 24 carbon atoms to liquid phase dehydration reaction in the presence of a solid acid catalyst, wherein among a total acid content of the solid acid catalyst as measured by an ammonia temperature-programmed desorption (NH | 2012-08-30 |
20120220809 | Disposal and Decontamination of Radioactive Polyvinyl Alcohol Products - Methods and apparatus for decontaminating disposable protective products prepared from polyvinyl alcohol (PVA), used in a nuclear power plant, to less than minimum detectable activity (MDA) are disclosed. In the disclosed methods and apparatus, solid protective products made of PVA, generated from a nuclear power plant, are dissolved into a liquid, and then are decontaminated to less than MDA. The PVA solution decontaminated in this way is concentrated to an appropriate concentration or dried, and finally is subjected to self-disposal. This can fundamentally block the generation amount of combustible waste amounting to 50% or more of low and intermediate level waste of nuclear power plants, thereby considerably contributing to a reduction of the operating expenses of the nuclear power plants. The present invention further relates to methods and apparatus for self-disposing disposable protective products manufactured by conventional polyvinyl alcohol (PVA) through pyrolysis/catalytic oxidation of a PVA solution generated by concentration, and treating the decontaminated PVA solution within a plant. The PVA protective products are dissolved/concentrated/oxidized in water to remove firstly organic matter, and then PVA materials in the PVA solution are completely oxidized into CO | 2012-08-30 |
20120220810 | Method for optimal paint residue stabilization - This invention provides an optimal method for stabilization of heavy metal bearing paint residue subject to acid and water leaching tests or leach conditions by addition of environmental safe, worker safe, and multi-media compatible stabilizing agents to the blast media, thus allowing for paint residue stabilization outside of or within an OSHA containment building or collection device, such that leaching of heavy metals such as lead are inhibited to desired levels. The resultant stabilized paint residue and spent blast media mixture is suitable for on-site reuse, off-site reuse, or disposal as RCRA non-hazardous waste. | 2012-08-30 |
20120220811 | Radiation Treatment Method For Use With A Radiation Treatment Bra - A method for radiation treatment includes adjusting a plurality of adjustable elements on a radiation treatment bra to establish a reference breast geometry and aligning the patient to a radiation treatment machine by projecting a light field through windows provided in the radiation treatment bra during a radiation treatment planning session. To begin actual radiation treatment, the reference breast geometry is reestablished by repeating the original adjustments of the adjustable elements, as necessary. Alignment is re-established by viewing tattoos through the windows in conjunction with the light field. | 2012-08-30 |
20120220812 | ULTRASOUND NEUROMODULATION FOR STROKE MITIGATION AND REHABILITATION - Disclosed are methods and systems and methods for neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke. The neuromodulation can produce acute effects or result in Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, pulse duration, frequency, firing pattern, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. The invention can be applied for mitigating the effects of stroke and/or in stroke rehabilitation. | 2012-08-30 |
20120220813 | DEVICES AND METHODS FOR APPLYING ENERGY TO A MUSCULAR LAYER - A device for delivering energy to a muscle may include a housing and at least one energy conduit associated with the housing. The at least one energy conduit may be configured to facilitate transfer of energy from an energy source that may be configured to provide energy to muscle within an organ. The device may further include a plurality of needles connected to the at least one energy conduit. Each needle may be configured to pierce tissue. The plurality of needles may include at least one needle configured to deliver energy through an energy emitting portion. The at least one needle may be sized so that when inserted into a wall of the organ, the energy emitting portion may be located within a muscle layer, and such that a majority of energy delivered via the at least one needle may be substantially confined to the muscle layer. | 2012-08-30 |
20120220814 | Personal item with energy enhancement arrangement - A personal item includes a body being carried by a user and a plurality of different energy elements secured in the body. The energy elements are selected from a group consisting of hologram element, germanium, and titanium, for generating a particular magnetic force which helps rebalance and restore natural energy pathways of the user. So, when the user carries the body, the energy elements are held close enough to the user in order to react positively with the user's energy field. Therefore, the personal item of the present invention is able to improve the blood circulation, recovery time, flexibility, strength, balance, healing and energy as well as contributing to an overall sense of health and well being among its users. | 2012-08-30 |
20120220815 | Pump-Inflow-Cannula, A Pump-Outflow-Cannula And A Blood Managing System - The invention relates to a pump-inflow-cannula ( | 2012-08-30 |
20120220816 | HEART ASSIST DEVICES, SYSTEMS AND METHODS - An apparatus and method for use in assisting a human heart are disclosed. The apparatus comprises an aortic compression means which may be fully implanatable, a fluid reservoir and a pump means adapted to pump a fluid from the reservoir to the aortic compression means so as to actuate the aortic compression means at least partly in counterpulsation with the patient's heart. In addition, the device is adapted to be wholly positioned within the right chest cavity of the patient. The aortic compression means of the device may be curved along its length so as to substantially replicate the curve of the ascending aorta. | 2012-08-30 |
20120220817 | FULL NEONATAL CRITICAL CARE EQUIPMENT - Equipment for the comprehensive care of high-risk newborns that ventilates, incubates, monitors and facilitates medical procedures. The equipment is comprised of: a thermal ring ( | 2012-08-30 |
20120220818 | Middle Ear Implant for Otosclerosis - A middle ear transducer arrangement is described for engaging a round window membrane of a patient cochlea. A mechanical transducer is surgically implantable into a fixed position in the round window niche of the patient cochlea adjacent to the round window membrane. A drive face on the outer surface of the transducer has a diameter less than half the diameter of the round window membrane. The fixed position of the transducer engages the drive face against a side section of the round window membrane without engaging the center point to generate an acoustic stimulation signal for perception as sound. | 2012-08-30 |
20120220819 | Stroller Mat - The invention provides a mat providing a surface for creating movement within a stroller having wheels rolled over the mat, where the mat has an upper and lower surface, the upper surface comprising a texture surface and spaced vertical extensions elevated over the textured surface, and where the mat is produced of a non-shock absorbing material. | 2012-08-30 |
20120220821 | Laminar Flow Endoscope - A laminar flow endoscopic instrument for laminar transmission of irrigation fluid between an incision towards a zone of visualization associated with a surgical site, the endoscopic portal comprising an osteoendoscopic cylinder having an outer contact surface encircling an inner visual surface and extending between a proximal handle end and a distal endoscopic end with a directional surface extending therefrom and providing laminar flow of irrigation fluid. | 2012-08-30 |
20120220822 | HAND-HELD ENDOSCOPIC DEVICE WITH A ROTATION CONTROL - The present invention is a hand-held endoscopic device with a rotation control, having a mainframe, a flexible cable, and a tube module. Moreover, the tube module includes a probe, a image capturing element and a sheath; besides, the second front end of the sheath has an opening which includes a mirror to allow the user to rotate the opening of the sheath in accordance with the situation, so that the image capturing element can reflect the light through the mirror to capture the image from different perspectives. | 2012-08-30 |
20120220823 | ENDOSCOPE APPARATUS CAPABLE OF PROVIDING NARROW BAND IMAGING AND IMAGE PROCESSING METHOD OF THE ENDOSCOPE APPARATUS - An endoscope apparatus and image processing method of an endoscope apparatus are provided. In one respect, an endoscope apparatus includes an illumination unit for selectively providing light in a plurality of wavelength bands and white light, a sensing unit for receiving light reflected from a body cavity, and an image processing unit for generating additional synthesized images. | 2012-08-30 |
20120220824 | ENDOSCOPE APPARATUS - An endoscope apparatus includes a light source unit, an imaging element, a density calculating section, and an image processing section, wherein the image processing section changes frequency processing conditions with respect to the captured image such that the detection and enhancement degree of the structure and components of the living body in the subject are changed according to at least the density of each pixel of the captured image. | 2012-08-30 |
20120220825 | ENDOSCOPE HAVING SIGNAL CABLE - An endoscope has a section of an elongated tube for entry in a body cavity. An end shell is disposed at a distal end of the elongated tube. An imaging window area is formed in the end shell. A lens barrel is secured to the end shell, and aligned with the imaging window area. An imaging device photoelectrically detects object light from the lens barrel. A circuit board has the imaging device mounted thereon. A signal cable has a cover material, and plural filaments covered by the cover material, and connected to the circuit board. A cable retaining device partially retains the cover material fixedly. A tip portion is formed at a distal end of the cable retaining device. A coupling device keeps the tip portion laterally movable on the end shell, to prevent stress in the cable retaining device from exertion to the end shell. | 2012-08-30 |
20120220826 | ENDOSCOPE APPARATUS - In an endoscope apparatus in which an imaging element and a circuit board to which the imaging element is connected are provided inside a distal end of an insertion part, disconnection between the circuit board and a signal wiring line is prevented. In an endoscope apparatus including an insertion part to be inserted into the body, an imaging element, a circuit board electrically connected to the imaging element and arranged parallel to the longitudinal direction of the insertion part, and a signal wiring line electrically connected to the circuit board and extending in the longitudinal direction are provided within the insertion part, and a connecting portion between the circuit board and the signal wiring line is provided with a easing member that eases a force applied to the connecting portion. | 2012-08-30 |
20120220827 | SHAPE MEMORY ARTHROSCOPIC CAMERA - A surgical instrument includes an elongated tubular member having a proximal end and a distal end. At least a portion of the elongated tubular member is resiliently deformable from an at-rest configuration. The elongated tubular member includes a camera assembly disposed therein. An outer shaft defining a lumen extending therethrough is positioned annularly about the elongated tubular member. At least one of the outer shaft and the elongated tubular member is moveable with respect to the other between a substantially overlapping position wherein the elongated tubular member is deformed to conform to the shape of the outer shaft, and a displaced position wherein at least a portion of the elongated tubular member extends distally from a distal end of the outer shaft. In the displaced position, the portion of the elongated tubular member extending from the outer shaft returns, or reforms back to the at-rest configuration. | 2012-08-30 |
20120220828 | IMAGE PICKUP APPARATUS FOR ENDOSCOPE - An image pickup apparatus for an endoscope includes: an image pickup device unit including an image pickup device; a lens unit including a moving lens; an actuator apparatus for an endoscope, the actuator apparatus including a first elastic member having an urging force that makes a moving lens frame be arranged at a first observation position, a second elastic member making the moving lens frame be arranged at a second observation position, and a shape memory alloy wire having a property of extending/contracting due to an applied current; a driving force transmitting wire arranged on a distal end side of the shape memory alloy wire; a pressing member, upon receipt of an elastic force from the second elastic member, pressing the moving lens frame to the second observation position; and a fixing portion that fixes the driving force transmitting wire and the shape memory alloy. | 2012-08-30 |
20120220829 | INSERTION ASSISTING DEVICE AND ENDOSCOPE APPARATUS - An insertion assisting device | 2012-08-30 |
20120220830 | JOINT ARRANGEMENT - An actuatable joint is disclosed having a transmission member, for example a ring gear, associated with a member of a joint and rotatable about a longitudinal axis through the member. In particular a two degree of freedom actuatable joint is disclosed comprising tendon driven joint arrangements having a transmission member disposed around or inside a body of the joint arrangement, to provide transmission of a force from a driving means to two tendons actuating a rotational degree of freedom of the joint arrangement. Further disclosed is a segmented device, for example an endoscope, comprising a plurality of such joints, for example to define a flexible and steerable conduit for an instrument. | 2012-08-30 |
20120220831 | SURGICAL TOOL HAVING POSITIVELY POSITIONABLE TENDON-ACTUATED MULTI-DISK WRIST JOINT - The present invention is directed to a tool having a wrist mechanism that provides pitch and yaw rotation in such a way that the tool has no singularity in roll, pitch, and yaw. A positively positionable multi-disk wrist mechanism includes a plurality of disks or vertebrae stacked in series. Each vertebra is configured to rotate in pitch or in yaw with respect to each neighboring vertebra. Actuation cables are used to manipulate and control movement of the vertebrae. In specific embodiments, some of the cables are distal cables that extend from a proximal vertebra through one or more intermediate vertebrae to a distal vertebra, while the remaining cables are medial cables that extend from the proximal vertebra to one or more of the intermediate vertebrae. The cables are actuated by a pivoted plate cable actuator mechanism. | 2012-08-30 |
20120220832 | ENDOSCOPE BENDING DEVICE - An endoscope bending device includes an operation wire which includes a wire proximal end movably provided in an inner peripheral groove of a pulley, and a wire distal end connected to a bending section, the operation wire extending into an endoscope insertion section after being wound around an outer peripheral groove or the inner peripheral groove in a neutral condition in which the bending section is not bent. The endoscope bending device includes a slack absorbing portion which is configured to absorb the slack of the operation wire by moving the wire proximal end of the operation wire in the inner peripheral groove in a direction opposite to a discharging direction of the operation wire during the operation of discharging the operation wire from the neutral condition. | 2012-08-30 |
20120220833 | HINGED TISSUE SUPPORT DEVICE - A tissue support device is provided for managing access through tissue. The tissue support device engages the tissue proximate an opening in the tissue and biases the tissue support device to bring the engaged tissue together. | 2012-08-30 |
20120220834 | STRAP BASED PHYSIOLOGICAL INFORMATION MONITORING SYSTEM HAVING AN ELECTRICAL CIRCUIT/S COVERING CASE WITH LOOP/S AND SENSOR BASES WITH LOOP/S - Present innovation describes a physiological information monitoring strap capable of monitoring at least one physiological information parameter such as ECG, heart rate, heart rate variability, skin temperature or respiration information. The system comprises of casing for the electronics with loop holes for the strap to be connected to the casing. Also the system is consists of sensor bases with loop holes so that the strap to be connected to the sensor bases. The electrical communications between the sensors of the sensor bases and the electrical circuits in the casing is done via wires or cables. | 2012-08-30 |