35th week of 2012 patent applcation highlights part 42 |
Patent application number | Title | Published |
20120220433 | OFFSET WEIGHT BARS - An offset weight bar is provided which operates with the lifter's neuro-fascial connections to increase muscle activation and recruitment of muscle groups. The offset weight bar includes a grip portion that is shaped in accordance with the neuro-fascial connections in the lifter's hands and arms. The offset weight bar also offsets the weight of the bar from the lifter's palm to a point out along the lifter's unfolded fingers. The shape of the offset weight bar operates with the offset of the weight from the palm to increase the lifter's muscle activation and muscle group recruitment in accordance with the lifter's neuro-fascial physiology. | 2012-08-30 |
20120220434 | ADJUSTABLE DUMBBELLS - A weight lifting system includes a handle unit having a handle bar, two head units attached to two end sections of the handle bar in a manner that allows the two head units to rotate about a longitudinal axis of the handle bar, two screw rods disposed through holes in the two head units into hollow sections in the handle bar, wherein the two screw rods have threads of opposite directions, two thread-engaging mechanisms fixedly disposed at the two end sections of the handle bar to fit snugly on the threads of the two screw rods, and a lock mechanism disposed in a head unit for controlling rotation of the handle bar; and a plurality pairs of weight discs, wherein each of the weight discs has a center hole configured to accommodate one of the two screw rods. | 2012-08-30 |
20120220435 | Apparatus and Method to Stretch Upper and Lower Extremities - An arm and/or leg stretching apparatus and method where one end of a steel (or other rigid material) cable can be connected to a post, tree or to anything that it can be wrapped around, and the other end fits a cuff that can be placed around the wrist or ankle so that the user can stretch by leaning or pulling against the cable. An alternate embodiment of the present invention can use a waist belt where again, the user uses his or her own weight to stretch against the cable. In the case of an arm stretch, the cuff relieves the user of having to grip something by attaching around the wrist. | 2012-08-30 |
20120220436 | Resistance Training Device and Method of Use - The present invention relates to an exercise training device and methods of use. The exercise training device comprises a harness that is worn on the exterior of the foot or shoe of a user, and an elastic resistance cord that releasably attaches to the harness, such that the connection between the elastic resistance cord and harness is positioned at the heel of the user. The exercise training device is used to improve the strength and balance of a user. For example, use of the device improves the throwing motion of a baseball pitcher. | 2012-08-30 |
20120220437 | TOOL MAGAZINE AND MACHINING CENTER - A tool magazine that can make a long tool reasonably coexist with other tools and a machining center with the tool magazine are provided. The tool magazine has a rotatable magazine main body and plural of tool holders installed on the magazine main body. Each of the tool holders moves to a tool exchange position sequentially. A part or all of the tool holders has a capability of changing between an exchange posture that holds the tool in parallel to a rotation shaft of the magazine main body and a transport posture that holds the tool along with a plane perpendicular to the rotation shaft of the magazine main body. The tool holder capable of changing postures takes the exchange posture when it locates in the tool exchange position and takes the transport posture when it leave the exchange position. The machining center has the above tool magazine. | 2012-08-30 |
20120220438 | Filter Rod Maker - A machine for making filter rods for use in the manufacture of smoking articles comprises a garniture configured to receive filter plug material and filter wrapping material and to form a wrapped elongate filter rod, the garniture comprising a tongue; the maker further comprises a rotatable object-transport member arranged to receive objects from an object store and to deliver said objects directly into the tongue such that the objects are inserted into filter plug material passing through the tongue and a cutter configured to cut the elongate filter rod, thereby forming filter rod segments having one or more objects therein. | 2012-08-30 |
20120220439 | Heat Sealing Jaw, Apparatus and Method - This invention relates to a method for sealing film layers to form a sealed portion and a notch within the sealed portion, comprising: providing film layers between sealing jaws comprising a heat sealing element, with a sealing face having a length and a protrusion extending partly along the length of its sealing face; inducing a temperature gradient along the of sealing face length, wherein the temperature proximate to the protrusion is higher than at a distance from the protrusion; closing the jaws and simultaneously clamping the film at a location adjacent to the sealing face; holding the jaws closed for a period of time; and opening the jaws to release the layers of film. | 2012-08-30 |
20120220440 | SHEET PROCESSING APPARATUS AND IMAGE FORMING SYSTEM - A sheet processing apparatus is provided with a conveying path forming member that forms a sheet conveying path having a curved portion through which a front edge of the sheet passes, a sheet conveying unit that conveys the sheet along the sheet conveying path, a sheet folding unit that folds the sheet along the folding line in the sheet conveying path, and then conveys the sheet toward a discharge direction with the folding line discharged first as a front edge, and a sheet position defining unit that defines a position of the front edge of the sheet in the curved portion of the sheet conveying path so that a target position of the folding line on the sheet coincides with a folding position of the sheet folding unit. The sheet position defining unit can adjust an inclination of the front edge of the sheet. | 2012-08-30 |
20120220441 | CONTINUOUS FLOW ULTRA-CENTRIFUGATION SYSTEMS - A continuous flow centrifuge system is provided. The system includes a rotor, a stator, a stator housing, upper and lower bearing plates, upper and lower bearings, first and second snap rings, and lip seal. The upper bearing rotatably secures a shaft of the rotor in the upper bearing plate. The first snap ring secures the upper bearing to the rotor shaft. The lip seal is over the upper bearing and forms a rotatable seal with the upper bearing plate. The second snap ring secures the lip seal to an inner diameter of the upper bearing plate. The upper and lower bearing plates are secured to the stator housing so that the rotor is operatively aligned with the stator. | 2012-08-30 |
20120220442 | OPTICAL GLASS AND CORE MATERIAL FOR OPTICAL FIBER - Provided is optical glass that does not contain lead, which is an environmental pollutant. The optical glass is ideal for the transmission of light even after being exposed to X-rays, and has a high refractive index. The optical glass comprises, by mass% in terms of oxide versus the glass total mass, 1.0% to 60.0% of an SiO | 2012-08-30 |
20120220443 | CERAMIC-BODY-FORMING BATCH MATERIALS COMPRISING SILICA, METHODS USING THE SAME AND CERAMIC BODIES MADE THEREFROM - The disclosure relates to ceramic-body-forming batch materials comprising at least one pore former and inorganic batch components comprising at least one silica source having a specified particle size distribution, methods of making ceramic bodies using the same, and ceramic bodies made in accordance with said methods. The disclosure additionally relates to methods for reducing pore size variability in ceramic bodies and/or reducing process variability in making ceramic bodies. | 2012-08-30 |
20120220444 | Ceramic Compositions for Improved Extrusion - A precursor batch composition that can be used to make porous ceramic articles is provided. The batch composition includes a polysaccharide gum. The batch composition may optionally include a linear water soluble polymer having a molecular weight of at least one million Daltons. | 2012-08-30 |
20120220445 | PROCESS FOR PRODUCING ALUMINUM TITANATE-BASED FIRED BODY, AND ALUMINUM TITANATE-BASED FIRED BODY - The present invention is a process for producing an aluminum titanate-based fired body, comprising shaping a starting material mixture containing inorganic compound source powders including an aluminum source powder and a titanium source powder, as well as an additive, degreasing the obtained shaped body at 150 to 900° C., and firing the degreased shaped body at not lower than 1300° C., wherein the inorganic compound source powders contain 1 to 5 parts by mass of particles having a particle diameter of not larger than 0.1 μm in 100 parts by mass thereof. | 2012-08-30 |
20120220446 | CARBON CATALYST, METHOD OF PRODUCING SAME, AND ELECTRODE AND BATTERY EACH UTILIZING SAME - Provided is a carbon catalyst having an improved activity. The carbon catalyst is obtained by: carbonizing raw materials containing an organic compound as a carbon source, a metal, and an electrically conductive carbon material to produce a carbonized material; impregnating the carbonized material with a metal; and subjecting the carbonized material with the metal to a heat treatment. | 2012-08-30 |
20120220447 | METHOD FOR MAKING A CATALYST COMPOSITION - A method for making a catalyst composition suitable for various purposes, such as the reduction of nitrogen oxides, is provided. The method includes combining dawsonite or a dawsonite derivative with a catalytic active element. | 2012-08-30 |
20120220448 | METHOD FOR REGENERATING A SOLID IODINE FILTER - A method for regenerating a solid filter containing iodine in the form of silver iodide and/or iodate and possibly molecular iodine physisorbed, in a solid filter containing silver in the form of nitrate. The iodine is extracted from the filter by putting the filter into contact with a basic aqueous solution containing a reducing agent. The extraction is achieved at room temperature, and then the filter is separated from this basic aqueous solution. Next, silver is extracted from the filter by putting the filter into contact with an acid aqueous solution. The filter is then separated from the acid aqueous solution. Finally, the filter is impregnated with silver by putting the filter into contact with a silver nitrate solution and then drying the filter. This method can be used in nuclear installations, notably factories for reprocessing used nuclear fuels. | 2012-08-30 |
20120220449 | PROCESS FOR VENTING A CATALYST COOLER - The process herein provide a catalyst cooler with a vent that communicates fluidizing gas to a lower chamber of a regenerator. Air that is used as fluidizing gas can then be consumed in the regenerator without promoting after burn in the upper chamber. | 2012-08-30 |
20120220450 | METHOD OF COATING CATALYST ON A SUBSTRATE - A method of coating a substrate with a catalytically active material using a polymer latex is disclosed. A slurry of catalytically active material and water is prepared, the catalytically active material containing activated carbon, and a binder is prepared that contains a polymer latex having a glass transition temperature of 10 C to 30 C. The slurry is combined with the binder to form a mixture, which can then be applied to the substrate to achieve a mixture loading of 20 to 30 weight percent on the substrate. The latex polymer binders can bind a catalytically active platinum on activated carbon powder to a cordierite honeycomb while not interfering with its catalytic activity, such as for hydrogenation. | 2012-08-30 |
20120220451 | OXIDATION CATALYST, ABSORBENT, AND MATERIAL FOR PURGING HARMFUL SUBSTANCES - An oxidation catalyst, comprising a carbon material prepared by calcining a transition metal compound and a nitrogen-containing organic substance, or a transition metal compound, a nitrogen-containing organic substance, and a carbon compound not containing nitrogen, the oxidation catalyst oxidizing at least one target substance selected from the group consisting of NO, CO, NH | 2012-08-30 |
20120220452 | ABSORBENT RESIN PARTICLES FOR WATER-STOPPING TAPE, AND WATER-STOPPING TAPE CONTAINING SAME - An object of the present invention is to provide absorbent resin particles for a water-stopping tape which are superior in absorption rate even when their average particle size is smaller or when their particle size distribution is wider. The present invention relates to absorbent resin particles for a water-stopping tape comprising a crosslinked polymer (A1) comprising a water-soluble vinyl monomer (a1) and/or a hydrolyzable vinyl monomer (a2) and a crosslinking agent (b) as essential constitutional units, wherein a hydrophobic substance (C) is present inside the absorbent resin particles in an amount of from 0.01 to 10.0% by weight relative to the weight of (A1) and (C) is present on the surface of the absorbent resin particles in an amount of from 0.001 to 1.0% by weight relative to the weight of (A1). | 2012-08-30 |
20120220453 | PESTICIDAL COMPOSTIONS AND PROCESSES RELATED THERETO - This document discloses pesticidal molecules having the following formula (“Formula One”): | 2012-08-30 |
20120220454 | SEED COATINGS, COATING COMPOSITIONS AND METHODS FOR USE - Coating compositions and methods of use, allowing for improved water and/or nutrient usage by seeds, plants, shrubs, and vegetation, among others, are disclosed. | 2012-08-30 |
20120220455 | Azolylmethyloxiranes, Their Use for Controlling Phytopathogenic Fungi and Compositions Comprising Them - The present invention relates to azolylmethyloxiranes of the general formula I | 2012-08-30 |
20120220456 | MICROCAPSULES CONTAINING MACROLIDE LACTONES ABAMECTIN, MILBEMECTIN, AVERMECTINS, MILBEMYCINS, EMAMECTINS, IVERMECTINS AND MECTINS IN GENERAL - Microencapsulated formulations of macrolide lactones (abamectin, milbemectin, milbemycins emamectin, avermectins, ivermectins) wherein the active ingredient is protected from UV-degradation, with exceptional release characteristics resembling those of an emulsion concentrate or, if desired, of long-lasting effect; further with appropriate rheological properties, and with reduced toxicity. The invention provides a unique microencapsulation process for the chemical stability and biological activity of mectins, e.g. abamectin, and provides microcapsules of mectins to be used in formulations CS, WG/CS, ZC, EC/CS and any formulation type containing microcapsules and combination with other biologically active ingredients. | 2012-08-30 |
20120220457 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME - Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo [1,2- a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds. | 2012-08-30 |
20120220458 | USE OF ABSCISIC ACID COMBINATIONS FOR THINNING - The present invention is directed to the treatment of a plant at the flowering or fruiting stage with an effective amount of abscisic acid, its analogs or derivatives and salts thereof to reduce the number of fruits that the plant sets and grows to maturity. | 2012-08-30 |
20120220459 | STABLE S-(+)-ABSCISIC ACID LIQUID AND SOLUBLE GRANULE FORMULATIONS - The present invention generally relates to stable S-(+)-abscisic acid liquid and soluble granule formulations and methods of making and using such formulations. | 2012-08-30 |
20120220460 | CONTROL OF AAD-1 MONOCOT VOLUNTEERS IN FIELDS OF DICOT CROPS - The subject invention relates in part to the control of AAD-1 monocot volunteers in fields planted with dicot crops such as soybeans or cotton. According to some embodiments of the subject invention, cyclohexanedione herbicides are selected as being an effective tool for controlling AAD-1 volunteers, as AAD genes do not impart tolerance to this class of graminicide chemistry. In addition, imidazolinone-class herbicides can be used in some preferred embodiments for selective control of conventional or herbicide-tolerant varieties of volunteer corn. AAD-1 corn comprising Event DAS-40278-9 is used in some particularly preferred embodiments. | 2012-08-30 |
20120220461 | CRYSTAL FORMS OF SULFONYLUREA COMPOUND AND METHOD FOR PRODUCING THE SAME - Crystal forms of sulfonylurea compound and method for producing the same. It has been found that a sulfonylurea compound of Formula (1): | 2012-08-30 |
20120220462 | INDUCING AGENT FOR PLANT ROOT - An inducing agent for plant root including a ketol unsaturated fatty acid having 5 to 24 carbon atoms, 1 to 6 double bonds between carbon atoms and an α ketol structure or γ ketol structure (in particular 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid is preferable), which inducing agent for plant root may be used to promote or induce the root growth even when transplanting by cutting plants for which root generation is hard such as pine, cedar, tea, chestnut, may be used even for root growth of cuttings of | 2012-08-30 |
20120220463 | Crystalline Complexes of 4-Hydroxy Benzoic Acid and Selected Pesticides - The present invention relates to crystalline complexes of 4-hydroxy benzoic acid and selected pesticides. It also relates to agriculturally useful compositions of the complexes. | 2012-08-30 |
20120220464 | USE OF SOPHOROLIPIDS AND DERIVATIVES THEREOF IN COMBINATION WITH PESTICIDES AS ADJUVANT/ADDITIVE FOR PLANT PROTECTION AND THE INDUSTRIAL NON-CROP FIELD - Use of sophorolipids as adjuvants in combination with pesticides as tank mix additive and/or as formulation additive for crop protection and for the industrial non-crop sector. | 2012-08-30 |
20120220465 | MgB2 SUPERCONDUCTIVE WIRE - The invention provides a MgB | 2012-08-30 |
20120220466 | Measurement and Monitoring of Cell Clonality - Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion. | 2012-08-30 |
20120220467 | Genetic Determinants of Prostate Cancer Risk - Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa). | 2012-08-30 |
20120220468 | TD PROBE AND ITS USES - The present invention relates to a target discriminative probe (TD probe) and its uses or applications. The TD probe is hybridized with a target nucleic acid sequence through both of the 5′-second hybridization portion and the 3′-first hybridization portion. When the TD probe is hybridized with a non-target nucleic acid sequence, both the 5′-second hybridization portion and the separation portion are not hybridized with the non-target nucleic acid sequence such that both portions form a single strand due to its low Tm value. As such, the TD probe exhibits distinctly different hybridization patterns for each of the target and the non-target nucleic acid sequence, discriminating the target nucleic acid sequence from the non-target nucleic acid sequence with much higher specificity. | 2012-08-30 |
20120220469 | TOXICITY TYPING USING LIVER STEM CELLS - This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian LSCs contacted with various chemical compositions of known and unknown toxicities, and correlating the molecular profiles with toxicities of the chemical compositions. | 2012-08-30 |
20120220470 | DIAGNOSTIC METHOD FOR DETECTING CANCER BY MEASURING AMOUNT OF A CYTOKINE LIKE IL-6 - The present invention relates to a diagnostic method for predicting the possible recurrence of tumours in cancer patients. The method comprises culturing blood cells from a patient suffering from cancer in the presence of a cytokine stimulating factor, where after the amount of induced cytokine thereby produced is determined giving an indication of the risk of recurrence of the cancer. | 2012-08-30 |
20120220471 | NANOANTENNA AND USES THEREOF FOR BIOSENSING - A metal nanoantenna for use in a biosensing device is disclosed. The metal nanoantenna is arranged to exhibit at least two particle plasmon resonances or surface plasmon resonances (SPRs). The nanoantenna is for use in a sensor and allows detection at low concentration of biological components. In one aspect, the nanoantenna can have an asymmetric structural configuration and spectrally separated resonances. In one aspect, there is a location in its structure providing local electromagnetic field enhancement at all of the SPRs. The metal nanoantenna can be used for background free measuring of a quantity of a biological component. | 2012-08-30 |
20120220472 | METHOD FOR INTEGRATING LARGE SCALE BIOLOGICAL DATA WITH IMAGING - There is disclosed a method of extracting large scale biological, biochemical or molecular information about an index disease, biological state, or systems from imaging by correlating the imaging features associated with said disease, state or system with corresponding large scale biological data. | 2012-08-30 |
20120220473 | METHOD OF IDENTIFYING TARGET BIOMOLECULE BY USING PROBE-BINDING FREQUENCY - An efficient and accurate method of identifying a target biomolecule in a sample by using target molecule-probe binding frequencies is disclosed. | 2012-08-30 |
20120220474 | METHODS AND COMPOSITIONS FOR DIAGNOSIS OF THYROID CONDITIONS - The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis. | 2012-08-30 |
20120220475 | DNA Methylation Changes Associated with Major Psychosis - The present invention provides a method of identifying one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia, the method comprising a) obtaining a first group of samples comprising genomic DNA from a plurality of bipolar or schizophrenic subjects and a second group of samples comprising genomic DNA from a plurality of control subjects; b) performing DNA methylation analysis to determine methylation differences in one or more DNA regions between the first group and second group of samples, wherein a methylation difference in a DNA region is indicative of an epigenetic marker associated with bipolar disease or schizophrenia. The invention also provides one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia. | 2012-08-30 |
20120220476 | BIOMARKERS FOR OVARIAN CANCER - The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject. | 2012-08-30 |
20120220477 | GENETIC MARKERS ASSOCIATED WITH RISK OF DIABETES MELLITUS - The invention relates to variants that predispose to risk of type 2 diabetes, basal cell carcinoma and breast cancer. It has been discovered that certain genetic variants confer risk of these diseases when inherited from one parent, but not the other. The invention provides methods of disease management, including diagnostic methods, utilizing such parental origin effects. | 2012-08-30 |
20120220478 | METHODS FOR ASSESSING DISEASE RISK - The invention relates to methods and biomarkers for assessing a subject's risk for a disease, such as cancer, an autoimmune disease or a neurological disease. In particular, the invention provides methods and biomarkers for creating exon copy number variation (ECNV) profiles, and determining disease risk according to the subject's ECNV profiles. | 2012-08-30 |
20120220479 | PROBES FOR SPECIFIC ANALYSIS OF NUCLEIC ACIDS - The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA; (b) rendering said fragments, including said target fragment, at least partially single-stranded, wherein the single-stranded portion includes an end portion and wherein the length of said single-stranded portion is sufficient to allow hybridisation of at least part of the single-stranded portion of said target fragment to the probe of step (c); (c) contacting the at least partially single-stranded fragments of step (b) with oligonucleotides A and B of a single target-specific nucleic acid probe, wherein: (i) oligonucleotide A is a single-stranded oligonucleotide comprising at one end a first target-specific part comprising at least 10 nucleotides complementary in sequence to at least part of said single-stranded portion of said target fragment, and comprising at the other end a second non-target-specific part which comprises a nucleotide sequence complementary to at least a portion, including one end, of oligonucleotide B of the probe, and (ii) oligonucleotide B is a single-stranded oligonucleotide which may contain or carry at least one element for detection and/or enrichment of said target fragment, and of which at least a portion, including one end, is complementary in sequence to the second non-target-specific part of oligonucleotide A, such that said target fragment becomes annealed to said probe through hybridisation to the first target-specific part of oligonucleotide A resulting in only one target-specific probe-binding event per target fragment; (d) ligating oligonucleotide B of said probe to the part of the single-stranded portion of said target fragment which is hybridised to oligonucleotide A of said probe to produce a probe-target fragment hybrid; and (e) detecting or enriching for said probe-target fragment hybrid. Kits for use in the method of the invention are also provided. | 2012-08-30 |
20120220480 | METHOD FOR THE DETECTION OF RENAL DAMAGE - The invention relates to a method for determining the presence of renal damage in an individual and also to a method for detecting one or several proteins selected from the list comprising Reg3B, fetuin B, Ras-related GTP-binding protein A serine protease inhibitor A3L, subunit 1 of COP9, gamma subunit of ATP synthase, gelsolin, ribonuclease UK114, aminoacylase 1A, alpha-enolase, keratin 5, parvalbumin alpha, ribonuclease 4 or serine protease inhibitor A3K. The renal damage may be acute renal failure. Said renal pathologies may be caused by the administration of a nephrotoxic agent, wherein the nephrotoxic agent may be an aminoglycoside antibiotic such as gentamicin, or cisplatin. The invention also provides means to differentiate the renal damage or renal failure induced by gentamicin from that induced by cisplatin, through the biochemical analysis of the urinary level of Reg3B and/or gelsolin, or fragments thereof. | 2012-08-30 |
20120220481 | BILAYERS - A method for producing a bilayer, the method comprising: (a) providing a hydrated support and a hydrophilic body immersed in a hydrophobic medium; wherein a first monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrophilic body and a second monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrated support; and (b) bringing the first monolayer into contact with the second monolayer to form a bilayer of amphipathic molecules, wherein at least part of a cell membrane, comprising cell membrane constituents, is provided in or on the hydrated support and/or in the hydrophilic body, and such that constituents of the cell membrane incorporate into the bilayer during or after the bilayer formation. A bilayer produced by the method of the invention, and uses of the bilayer. | 2012-08-30 |
20120220482 | COMPOSITIONS AND METHODS FOR SCREENING PEPTOID LIBRARIES - Certain embodiments are directed to methods for screening synthetic libraries and characterizing the resultant hits that combines many of the attractive features of bead library screening and microarray-based analysis in a seamless fashion. | 2012-08-30 |
20120220483 | METHODS FOR FRAGMENTATION AND LABELING OF NUCLEIC ACIDS - The invention provides methods, compositions, and kits for fragmentation and labeling of nucleic acids. More particularly, the invention relates to methods for fragmentation of nucleic acids to produce fragments with 3′ end hydroxyl groups within a desired size range. In methods of the invention, nucleic acids are fragmented at abasic sites to produce fragments with blocked 3′ ends. The 3′ ends are unblocked to produce polynucleotide fragments with hydroxyl groups at their 3′ ends. Methods, kits, and compositions for carrying out fragmentation of a polynucleotide template in a single reaction mixture to yield fragments with 3′-hydroxyl ends within the desired size range are disclosed. | 2012-08-30 |
20120220484 | TISSUE REJECTION - This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection. | 2012-08-30 |
20120220485 | PROBE SET AND METHOD FOR IDENTIFYING HLA ALLELE - Provided is a probe set that is useful for identifying each allele of HLA individually, and a method of identification of an allele of HLA by the use thereof for each type. | 2012-08-30 |
20120220486 | METHODS AND APPARATUS FOR BINDING ASSAYS - The present teachings relate to methods, systems, and apparatus for low cost label-free assay detection. The present teachings, in a variety of embodiments, employ opposing forces to detect signals which depend on the number of charges on and/or the size of a particle. The particle, which can be subjected to opposing forces, can have specific capture probes at its surface. As analytes of interest are captured by the particle, the number of charges on the particle surface and/or the size of the particle is changed. A particle parameter or kinematic property such as the position, velocity, acceleration or force of/on the particle can be measured, and results obtained relating, for example, to the present, absence, quantity, and such, of one or more analytes of interest. Various embodiments are described for efficient, high throughput assays of samples potentially including one or more analytes of interest, such as bioanalytes. As well, various embodiments are described wherein binding assays can be carried out without the need or use of extrinsic labels. A number of embodiments provide, for example, methods, systems, and apparatus for detecting analytes (such as nucleic acids, proteins, cells and other entities, particulates, and the like) in one or more samples. Also described are: detection of a single copy of a target biomolecule, such as DNA, captured onto a trapped (e.g., tethered) bead; protocols for fabricating encoded bead arrays for multiplex assays; and methods, systems and apparatus for efficient and specific capture of pathogen biomolecular markers onto bead-bound capture probes, as well as detection and measurement of such capture events. | 2012-08-30 |
20120220487 | Determination of 17q Gain in Neuroblastoma Patients by Analysis of Circulating DNA - Methods for diagnosis of neuroblastoma comprising determining whether there is a gain of genetic material from chromosome arm segment 17q21-qter in the circulating DNA of a human subject. | 2012-08-30 |
20120220488 | HEART AGING BIOMARKERS AND METHODS OF USE - The invention provides a set of robust biomarkers of aging in the heart comprising several genes involved in the Wnt signaling pathway. These genes have been found to be down-regulated in aged versus young heart tissue. Methods of using those biomarkers to monitor heart aging and to identify nutrients and dietary regimens for retarding heart aging are disclosed. Methods for the modulation of the genes themselves to retard heart aging are also disclosed. | 2012-08-30 |
20120220489 | CALIBRATION REAGENT AND USES THEREOF - The present invention provides a calibration reagent comprising a peptide conjugated to a protein carrier via a linker, wherein said peptide comprises an epitope of interest and the use thereof. | 2012-08-30 |
20120220490 | METHOD AND COMPOSITIONS FOR DETECTING BOTULINUM NEUROTOXIN - The present invention provides a molecular construct capable of fluorescent resonance energy transfer (FRET), comprising a linker peptide, and donor and acceptor fluorophore moieties, where the linker peptide is a substrate of a botulinum neurotoxin selected from the group consisting of synaptobrevin, syntaxin and SNAP-25, or a fragment thereof capable being cleaved by the botulinum neurotoxin, and separates the donor and acceptor fluorophores by a distance of not more than 10 nm, and where emission spectrum of the donor fluorophore moiety overlaps with the excitation spectrum of the acceptor fluorophore moiety; or where the emission spectra of the fluorophores are detectably different. Also provided are isolated nucleic acid expressing the construct, kits comprising said construct and cell lines comprising said nucleic acid. Further provided are methods of detecting a BoNT using the above described construct via FRET, and methods for detecting a BoNT using surface plasmon resonance imaging. | 2012-08-30 |
20120220491 | RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE - Analytes in a sample are resolved by retentate chromatography in a procedure involving adsorbing the analytes on a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery. | 2012-08-30 |
20120220492 | Viral Vectors with Improved Properties - Methods to improve the tropism or other features of a virus are disclosed. Such methods can be used to prepare, e.g., DNA or plasmid libraries of variants of a gene encoding a viral capsid or envelope protein having a randomly inserted restriction site, libraries of viral clones with such variant genes with a randomly inserted restriction site or polypeptide sequence targeting a receptor expressed by a specific type of mammalian cells. Described are also methods to prepare mosaic viruses, i.e., viral particles wherein copies of one or more capsid or envelope proteins originate from different sources. These methods can be used to prepare mosaic viruses of a specific mixture of wild-type and mutant proteins, or of different types of mutant proteins. | 2012-08-30 |
20120220493 | BIOMARKER FOR DIAGNOSIS, PREDICTION AND/OR PROGNOSIS OF ACUTE HEART FAILURE AND USES THEREOF - The application discloses MCAM as a new biomarker for acute heart failure; methods for predicting, diagnosing, prognosticating and/or monitoring acute heart failure based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods. | 2012-08-30 |
20120220494 | COMPOSITIONS AND METHODS FOR MOLECULAR LABELING - The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR. | 2012-08-30 |
20120220495 | ARRAYS OF MICROPARTICLES AND METHODS OF PREPARATION THEREOF - This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays. | 2012-08-30 |
20120220496 | siRNA Targeting Catenin, Beta-1 (CTNNB1) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CTNNB1. | 2012-08-30 |
20120220497 | Methods and Microfluidic Devices for the Manipulation of Droplets in High Fidelity Polynucleotide Assembly - Methods and devices are provided for manipulating droplets on a support using surface tension properties, moving the droplets along a predetermined path and merging two droplets together enabling a number of chemical reactions. Disclosed are methods for controlling the droplets volumes. Disclosed are methods and devices for synthesizing at least one oligonucleotide having a predefined sequence. Disclosed are methods and devices for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different oligonucleotides having a predefined sequence. In exemplary embodiments, the methods involve synthesis and/or amplification of different oligonucleotides immobilized on a solid support, release of synthesized/amplified oligonucleotides in solution to form droplets, recognition and removal of error-containing oligonucleotides, moving or combining two droplets to allow hybridization and/or ligation between two different oligonucleotides, and further chain extension reaction following hybridization and/or ligation to hierarchically generate desired length of polynucleotide products. | 2012-08-30 |
20120220498 | FLUORESCENCE ANALYZING METHOD, FLUORESCENCE ANALYZING APPARATUS AND IMAGE DETECTING METHOD - A fluorescence analyzing method includes the steps of irradiating a board, to which oligonucleotide is fixed, with light for fluorescence measurement; focusing produced fluorescence to form an image; and detecting the fluorescence with a two-dimensional sensor. Here, the board is provided with plural regions to which the oligonucleotide is fixed, and the plural regions are spaced apart from one another on the board substantially equidistantly in the vertical and horizontal directions. A fluorescent image is detected in a condition where the following equation is satisfied: | 2012-08-30 |
20120220499 | Treatment Process For Inhibiting Top Of Line Corrosion Of Pipes Used In The Petroleum Industry - The subject-matter of the present invention is multifunctional corrosion inhibitors for protecting from top of line corrosion and bottom line corrosion for pipes used in particular in the petroleum industry. | 2012-08-30 |
20120220500 | Process for Removal of Hydrogen Sulfide in Downhole Oilfield Applications - A method and system remove hydrogen sulfide from a hydrocarbon containing fluid. In an embodiment, the method for removing hydrogen sulfide from a hydrocarbon containing fluid includes contacting a methylmorpholine-N-oxide solution with the hydrocarbon containing fluid. The method also includes allowing the methylmorpholine-N-oxide to react with the hydrogen sulfide to remove the hydrogen sulfide. | 2012-08-30 |
20120220501 | NON-AQUEOUS, ACID SOLUBLE, HIGH-DENSITY COMPLETION FLUIDS AND PROCESS - Disclosed herein is a method comprising displacing a first oil-based fluid present in an open hole interval of a wellbore with a second fluid; and contacting the second fluid with an acidic indigenous formation fluid to produce a third fluid wherein the second fluid an aqueous fluid dispersed as a discontinuous phase within an oleaginous fluid, and an amine surfactant, wherein the amine surfactant is selected such that contacting the second fluid with indigenous fluid protonates at least a portion of the amine surfactant in the second fluid to produce the third fluid comprising an emulsion comprising the oleaginous fluid reversibly dispersed as a discontinuous phase within the aqueous fluid. A system for treating a subterranean well and a fluid are also disclosed. | 2012-08-30 |
20120220502 | COMPOSITIONS COMPRISING ALKYLALKOXYSULFONATES FOR THE PRODUCTION OF HIGH TEMPERATURE STABLE FOAMS - The present invention is directed to the use of alkylalkoxysulfonates for the production of foams, which are stable at high temperatures, e.g. up to about 250° C. Furthermore, the invention relates to a method for producing of high temperature stable foams by using a foamable aqueous composition comprising at least one linear alkylalkoxysulfonate. | 2012-08-30 |
20120220503 | COMPOSITION AND METHOD FOR TREATING WELL BORE IN A SUBTERRANEAN FORMATION WITH CROSSLINKERS POLYMER FLUIDS - The concentrate solution for the crosslinking of polymers comprises water, polyol, a viscosifying agent, a first borate ion in solution, and a crosslinking agent able to release a second borate ion, wherein the second borate ion is not in solution. | 2012-08-30 |
20120220504 | Consolidating Agent Emulsions and Associated Methods - Consolidation fluids comprising: an aqueous base fluid comprising a hardening agent; an emulsified resin having an aqueous external phase and an organic internal phase; a silane coupling agent; and a surfactant. The consolidation fluid itself may be emulsified and further comprise an emulsifying agent. The consolidation fluid may also be foamed in some cases. | 2012-08-30 |
20120220505 | Farm Tractor Lubricating Composition with Good Water Tolerance - A lubricant of (a) an oil of lubricating viscosity; (b) a block copolymer of (i) a hydrophobic first block of C | 2012-08-30 |
20120220506 | Star Polymer and Lubricating Composition Thereof - The present invention relates to a lubricating composition containing an oil of lubricating viscosity and a star polymer that has at least two inner blocks, at least one of which is in turn bonded to one or more outer blocks. The invention further relates to methods of lubricating a mechanical device with the lubricating composition. | 2012-08-30 |
20120220507 | 2,5-FURAN DICARBOXYLATE DERIVATIVES, AND USE THEREOF AS PLASTICIZERS - The invention relates to mixtures of isononyl furan-2,5-dicarboxylate of formula (I), methods for producing said mixtures of isononyl furan-2,5-dicarboxylate of formula (I), compositions containing mixtures of isononyl furan-2,5-dicarboxylate of formula (I), uses of the mixtures of isononyl furan-2,5-dicarboxylate of formula (I) as plasticizers, and uses of the aforementioned compositions containing isononyl furan-2,5-dicarboxylate of formula (I). | 2012-08-30 |
20120220508 | Lubricant Compositions - Suggested is a method for enhancing energy efficiency of engines by applying to said engines a lubricant composition containing (A) carboxylic esters derived from the reaction of mono-, di- and/or poly alcohols with mono- and/or dicarboxylic acids, together with an additive blend (B) comprising at least two different additives (a) and (b) together, whereby compound (a) is selected from dithiophosphates, and compound (b) is selected from alkylated phosphorothionates, on condition that the total amount of the additive blend (B) is below 0.1 wt %, calculated on the weight of the whole composition. | 2012-08-30 |
20120220509 | Oil Recovery Method - The invention relates to a method for the recovery of oil from an aqueous solution containing oil and solids, as well as to the use of products obtained by this method. The method of the invention comprises at least the following steps of: Adjusting the oil- and solids-containing aqueous solution to a pH which is acidic, separating an oil- and solids-containing fraction from the acidic aqueous solution with an separation agent which is hydrophilic or assumes a hydrophilic character in response to water, recovering the oil- and solids-containing fraction separated by means of said separation agent, extracting oil away from the solids with a water-insoluble extraction agent, and recovering the oil-containing water-insoluble extraction agent. | 2012-08-30 |
20120220510 | Non-Migrating Colorants In Multi-Phase Personal Cleansing Compositions - A multi-phase personal cleansing composition comprising: (a) a structured aqueous cleansing phase comprising a surfactant and water; and (b) at least one additional, non-lamellar aqueous phase; wherein at least one of said structured aqueous cleansing phase and said additional aqueous phase comprises at least one non-migrating colorant, said non-migrating colorant comprising a c Log P value of at least about 2; and wherein said structured aqueous cleansing phase and said additional aqueous phase are packaged in physical contact with one another. | 2012-08-30 |
20120220511 | PRINTING PRESS CLEANING COMPOSITIONS - Disclose herein are compositions of matter comprising at least one hydrocarbon solvent in between 1-50%, at least one surfactant in between 1-50%, and/or at least one aromatic solvent in between 1-75%. In addition, disclosed herein is a method of cleaning rollers, plates, or blankets of a printing machine with a cleaning mixture, the method comprising contacting the rollers or blankets with the cleaning mixture, wherein the cleaning mixture comprises a hydrocarbon solvent, an aromatic solvent, a methylated siloxane, and a surfactant. | 2012-08-30 |
20120220512 | POT AND PAN SOAKING COMPOSITION - A soaking composition including an alkalinity source, a metal protector, a surfactant, water, a threshold agent, a binding agent, and a polymer blend that functions as a binding agent and a hard water modifier. The polymer blend includes a polymaleic acid, a polycarboxylic acid and a sodium polyacrylate. | 2012-08-30 |
20120220513 | Polypeptides Having Detergency Enhancing Effect - The present invention relates to the use of glycosyl hydrolase family 61 polypeptides as enhancers of enzyme benefits in detergents as well as a detergent composition comprising glycosyl hydrolase family 61 polypeptides in combination with detergency enzymes. | 2012-08-30 |
20120220514 | CAPSULES AND COMPOSITIONS COMPRISING THE SAME - A seamless capsule comprises at least one core and a shell layer. The capsule can further comprise an intermediate layer which surrounds the core(s) and is surrounded by the shell layer. The shell layer comprises a material selected from the group consisting of water-soluble polymers, water-dispersible polymer, hydrogels. The shell layer can further comprise a disintegration aid. | 2012-08-30 |
20120220515 | CAPSULES AND COMPOSITIONS COMPRISING THE SAME - A seamless capsule comprises at least one core and a shell layer. The capsule can further comprise an intermediate layer which surrounds the core(s) and is surrounded by the shell layer. The shell layer comprises a material selected from the group consisting of water-soluble polymers, water-dispersible polymer, hydrogels. The shell layer can further comprise a disintegration aid. | 2012-08-30 |
20120220516 | Bar Soap Comprising Pyrithione Sources - A bar soap comprising a pyrithione source, a soap surfactant, and a pH adjusting agent selected from a group consisting of ammonia solution, triethanolamine, diethanolamine, monoethanolamine, potassium hydroxide, sodium hydroxide, soluble carbonate salts, and combinations thereof, wherein the bar soap attains a pH of greater than or equal to 10.7. A process of inhibiting the formation of a discoloration in a bar soap comprising pyrithione sources by adding pH adjusting agent to attain a pH of greater than or equal to 10.7. A process of inhibiting the formation of a discoloration in a bar soap caused by dissolved ferric ions and/or cupric ions and pyrithione sources in the bar, comprising the step of adding from about 0.3% to about 20% soluble carbonate salt during manufacturing of the bar soap. | 2012-08-30 |
20120220517 | Glycopegylation Methods and Proteins/Peptides Produced by the Methods - The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide. | 2012-08-30 |
20120220518 | THERAPEUTIC AGENT DELIVERY SYSTEM AND METHOD - A therapeutic agent delivery system includes a therapeutic agent delivery platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of being implanted in a tissue being treated. The platform includes a substrate and at least one host molecule coupled to the substrate. The therapeutic guest agent is capable of reversibly coupling with the host molecule when administered to the tissue being treated. The reversible coupling is defined by the binding affinity between the host molecule and the therapeutic guest agent. The therapeutic guest agent is delivered at a rate determined by the affinity release rate between the host molecule and the therapeutic guest agent. The degradation rate of the therapeutic guest agent may be slower than the affinity release rate between the host molecule and the therapeutic guest agent. | 2012-08-30 |
20120220519 | Peptide Aptamers that Bind to the Rep Proteins of ssDNA Viruses - Polypeptides and fusion proteins that bind to eukaryotic viruses, in particular, eukaryotic single-stranded DNA (ssDNA) viruses are provided. The polypeptides and fusion proteins bind to the replication initiation proteins (Rep) of ssDNA viruses and optionally inhibit viral replication and/or viral infection. The virus can be a plant pathogen or animal pathogen. Consensus sequences used to identify polypeptides that bind to eukaryotic viruses are also provided. | 2012-08-30 |
20120220520 | BIOAVAILABLE COMBINATIONS FOR HCV TREATMENT - The present invention relates to the combination comprising an HCV NS3/4a protease inhibitor and a compound of formula (II). The combination is useful to improve the bioavailability of the HCV NS3/4a protease inhibitor. As such, the combination is useful for treating conditions associated with the Hepatitis C virus in patients. Pharmaceutical compositions and kits comprising this combination, and processes for preparing the combination and the pharmaceutical formulations are also provided. | 2012-08-30 |
20120220521 | MODIFIED PEPTIDES HAVING TOXIN-ENHANCING EFFECTS - This invention relates in part to modifying BtBooster (BtB) peptides, in part to increase their stability in insect midgut digestive juices. Some preferred embodiments of BtB have removed proteinase cleavage sites resulting in increased stability of the modified BtB in the insect gut, while retaining the ability to enhance B.t. proteins for improved insect control. In some preferred embodiments, the protease-stable BtB is used in combination with B.t. spores and/or crystals comprising a Cry protein. Also reported herein is the significant and increased enhancement of Bt toxins against relatively Bt-tolerant insects ( | 2012-08-30 |
20120220522 | ESTER INSULIN - Compositions and methods related to ester insulin or derivatives thereof are provided. The compositions include Glu | 2012-08-30 |
20120220523 | USE OF A CORN PEPTIDI HYDROLYZATE AS AN ACTIVE AGENT STIMULATING HAIR GROWTH - The invention relates to the use of a composition comprising at least one corn ( | 2012-08-30 |
20120220524 | ASSAYS FOR CANCER PATIENT MONITORING BASED ON LEVELS OF ANALYTE COMPONENTS OF THE PLASMINOGEN ACTIVATOR SYSTEM IN BODY FLUID SAMPLES - The present invention describes methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of cancer treatment, in a cancer patient by measuring the levels of one or more analytes of the plasminogen activator (uPA) system, namely, uPA, PAI-1 and the complex of uPA:PAI-1, in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment. An increase or elevation in the levels of one or more of the PA system analytes in the cancer patient compared with the levels one or more of the respective PA system analytes in normal control individuals serves as an indicator of cancer advancement or progression. | 2012-08-30 |
20120220525 | Stablized Melanocortin Ligands - Compositions and methods are disclosed for a non-naturally occurring melanocortin ligand comprised of a melanocortin analog coupled to a degradation-resistant C-terminal extension and, optionally, an N-terminal extension, to produce a stable melanocortin ligand having diminished or abolished cardiovascular activity while retaining desired melanocortin regulatory activity. | 2012-08-30 |
20120220526 | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and other Disorders - The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer. | 2012-08-30 |
20120220527 | METHODS AND MATERIALS FOR REDUCING PLATELET COUNTS AND/OR PLATELET ADHESION - This document relates to methods and materials for treating diseases or disorders associated with elevated platelet counts (e.g., essential thrombocythemia, secondary thrombocytosis, congenital amegakaryocytic thrombocytopenia, sepsis, or asplenism) as well as methods and materials for treating diseases or disorders associated with elevated platelet adhesion to collagen (e.g., acute coronary syndromes, angina pectoris, chronic atherosclerosis, diabetes, or hypertension). | 2012-08-30 |
20120220528 | SYSTEMS AND METHODS FOR THERAPY OF KIDNEY DISEASE AND/OR HEART FAILURE USING CHIMERIC NATRIURETIC PEPTIDES - Medical systems and methods for treating kidney disease alone, heart failure alone, kidney disease with concomitant heart failure, or cardiorenal syndrome are described. The systems and methods are based on delivery of a chimeric natriuretic peptide to a patient. Methods for increasing peptide levels include direct peptide delivery via either an external or implantable programmable pump. | 2012-08-30 |
20120220529 | NITRIC OXIDE-BLOCKED CROSS-LINKED TETRAMERIC HEMOGLOBIN - The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the hemoglobin has a reduced ability to bind with nitric oxide. Preferably, the hemoglobin is deoxygenated, endotoxin free, and stroma free. The present invention also includes method of preparation, process of preparation and the method of use including supplementing blood volume in mammals and treating disorders in mammals where oxygen delivery agents are of benefit. | 2012-08-30 |
20120220530 | ALBUMIN VARIANTS - The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin. | 2012-08-30 |
20120220531 | SURFACTANT PROTEIN D FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH LUNG INJURY - Surfactant protein D (SP-D) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (BPD). | 2012-08-30 |
20120220532 | METHOD FOR IDENTIFYING A SUBJECT AT RISK OF DEVELOPING HEART FAILURE BY DETERMINING THE LEVEL OF GALECTIN-3 OR THROMBOSPONDIN-2 - The present invention relates to a method for identifying a subject at risk of developing hypertensive end organ damage, such as and in particular heart failure, comprising: a) obtaining a biological sample of said subject; b) determining the level of at least one non-myocytal marker in said sample; c) comparing the level of said marker to a standard level; and d) determining whether the level of the marker is indicative of a risk for developing hypertensive end organ damage. The non-myocytical marker preferably is galectin-3 or thrombospondin-2. | 2012-08-30 |