35th week of 2013 patent applcation highlights part 53 |
Patent application number | Title | Published |
20130224787 | FLOW CYTOMETER METHOD AND APPARATUS - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 2013-08-29 |
20130224788 | METHOD FOR DETECTING MICROORGANISMS WITH A SPECIMEN - A process for preparing reagents for a microorganism detection test comprising: a) centrifuging medium containing a microorganism; b) filtrating the supernatant from (a); c) preparing diluted samples of the filtrate from (b); d) treating the diluted samples from (c) with an E/M field; e) detecting signals emitted from (d) using a solenoid; f) selecting samples from (e) whose signal amplitude is ≧1.5 times greater than background noise emitted by water or that present a frequency displacement towards higher values; g) placing the diluted samples from (f) into an enclosures protecting against external electromagnetic fields; h) splitting a diluted sample from (g), volume by volume, into two tubes, T | 2013-08-29 |
20130224789 | METHODS OF MONITORING AND ANALYZING METABOLIC ACTIVITY PROFILES DIAGNOSTIC AND THERAPEUTIC USES OF SAME - A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: | 2013-08-29 |
20130224790 | Chalcone Structure Fluorescence Dye For Embryonic Stem Cell Probe - The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells. | 2013-08-29 |
20130224791 | SYSTEMS AND METHODS FOR MONITORING TISSUE SAMPLE PROCESSING - A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. | 2013-08-29 |
20130224792 | Novel 7 alpha-Hydroxysteroid Dehydrogenase Knockout Mutants and Use Therefor - The invention relates to novel microbial 7α-hydroxysteroid dehydrogenase (7α-HSDH) knockout mutants and to the use thereof for producing other HSDHs having various functionalities, such as 3α-, 7β- or 12α-HSDH, and to the use of thus-produced HSDH enzymes in enzymatic reactions of cholic acid compounds, and in particular for producing ursodeoxycholic acid (UDCS). The invention relates in particular to novel methods for synthesizing UDCS. | 2013-08-29 |
20130224793 | MODIFIED T7-RELATED RNA POLYMERASES AND METHODS OF USE THEREOF - The invention relates to modified T7-related RNA polymerases and methods of use thereof. In some embodiments, the invention relates to modified T7-related RNA polymerases that transcribe RNA with reduced abortive cycling and increased efficiency compared with native T7-related RNA polymerases. | 2013-08-29 |
20130224794 | MINERAL-PEPTIDE CHELATES - The present invention provides a mineral-peptide chelate comprising a peptide consisting of 2˜18 amino acids and a mineral chelated to the peptide, wherein the peptide can be a hydrolysate obtained by hydrolyzing soybean or other protein materials with proteases, or a product obtained by hydrolyzing soybean or other protein material with proteases and fermentation. The mineral-peptide chelate of the present invention may further comprise a carrier which covers the peptide and the mineral which is chelated to the peptide. | 2013-08-29 |
20130224795 | IMMOBILIZATION METHOD OF BIOACTIVE MOLECULES USING POLYPHENOL OXIDASE - A method is provided for immobilizing a bioactive molecule onto a surface using polyphenol oxidase. In the presence of polyphenol oxidase, a bioactive molecule containing a phenol or catechol group can be simply in situ oxidized within a short time to dopa or dopaquinone which forms a coordinate bond with a metal or polymer substrate, thus immobilizing the bioactive molecule onto the surface with stability. Based on the surface immobilization of bioactive molecules using polyphenol oxidase, various bioactive molecules such as osteogenetic peptides and growth factors can be simply immobilized to medical metal or polymer substrate surfaces such as orthopedic or dental implants which can be then effectively used to induce rapid osteogenesis after being transplanted. Also, antithrombotic agents and/or entothelialization inducing agents may be immobilized to medical substrates for vascular systems, such as stents and artificial blood vessels, thus guaranteeing hemocompatibility to the medical substrates. | 2013-08-29 |
20130224796 | GENETICALLY ALTERED CILIATES AND USES THEREOF - Ciliate organisms are provided that comprise reduced proteolytic processing in granules. For example, ciliates are provided that lack detectable expression of one or more sortilin (SOR) gene product. Methods for producing such genetically altered ciliates and methods for protein production in a these organisms are also provided. | 2013-08-29 |
20130224797 | METHOD FOR PRODUCING GLYCOPROTEIN HAVING MANNOSE RESIDUE AS NON-REDUCING END OF SUGAR CHAIN - Disclosed is a method for producing a glycoprotein using mammalian cells, wherein all or part of the non-reducing ends of N-glycoside binding sugar chains are mannose residues. The method is a method for producing glycoproteins using transformant mammalian cells which are prepared by introducing thereinto a β-N-acetylglucosaminidase gene and inducing its expression. | 2013-08-29 |
20130224798 | Methods of Making Hemagglutinin Proteins - Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion. The protein portion includes at least a portion of a globular head, and at least a portion of at least one secondary structure having at least one β-sheet at a bottom of the globular head that causes the globular head to essentially retain its tertiary structure. The protein portion made by the methods of the invention lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. A nucleic acid sequence encoding the protein portion is transformed into a prokaryotic host cell. | 2013-08-29 |
20130224799 | METHOD FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS - A method is disclosed for improved isothermal amplification of nucleic acids comprising the step of release of an essential component from a matrix under predetermined conditions. Furthermore, the invention relates to a kit comprising mesophilic enzyme and a matrix with embedded essential components for isothermal amplification. A composition comprising a matrix and a mesophilic enzyme and a method for embedding a mesophilic enzyme are disclosed as well. | 2013-08-29 |
20130224800 | Enzymes Having Alpha Amylase Activity and Methods of Making and Using them - The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at acidic, neutral and alkaline pH and increased temperature. | 2013-08-29 |
20130224801 | TREATMENT OF CELLULOSIC MATERIAL AND ENZYMES USEFUL THEREIN - The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations. | 2013-08-29 |
20130224802 | Methods of Hydrolyzing Oligomers in Hemicellulosic Liquor - The present invention relates to methods of degrading or converting biomass material enriched with hemicellulosic material into fermentable sugars. | 2013-08-29 |
20130224803 | COMPOSITE COMPONENTS FROM ANAEROBIC DIGESTED FIBROUS MATERIALS - The invention relates to composite components and methods of producing composite components. In yet another embodiment, the present invention relates to a method of producing a composite component using anaerobically digested biomass. In still yet another embodiment, the method further comprises using liquid effluent from the digester. In still yet another embodiment, the method further comprises wet-mat forming and cold pressing the anaerobically digested biomass and wet-mat drying under heat and pressure. | 2013-08-29 |
20130224804 | EXPRESSION OF STEADY STATE METABOLIC PATHWAYS - The present disclosure pertains to a method for increasing the production of a desired product having: identifying a steady state metabolic pathway for the synthesis of a desired product from a desired substrate; producing a polynucleotide encoding one or more polypeptide that participates in the steady state metabolic pathway for the synthesis of the desired product from the desired substrate; introducing the polynucleotide encoding a polypeptide into a host cell; transforming a host cell with an expression vector having an expressible polynucleotide encoding a polypeptide; and cultivating the host cell under a culture condition that induces the production of the desired product. | 2013-08-29 |
20130224805 | System and Method for Converting Cellulosic Biomass into a Sugar Solution - A process and apparatus for converting cellulosic biomass pulp into a sugar solution is provided. The process includes combining a quantity of cellulosic biomass pulp with a quantity of acid and a quantity of enzyme. The combined quantity of cellulosic biomass pulp, enzyme, and acid are placed in an enzymatic hydrolysis reactor having a predetermined temperature range and predetermined pH level, thereby producing a quantity of monomeric sugar solution. | 2013-08-29 |
20130224806 | Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family - A method for producing an L-amino acid is described using a bacterium of the Enterobacteriaceae family, wherein the bacterium contains a protein which is able to confer resistance to growth inhibition by L-cysteine. | 2013-08-29 |
20130224807 | METHODS OF PRODUCING CARBOXYLIC ACIDS - The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other α,ω-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency. | 2013-08-29 |
20130224808 | PROCESS AND APPARATUS FOR PRODUCING ETHYLENE VIA PREPARATION OF SYNGAS - A process for producing ethylene from a carbonaceous containing feedstock the process comprising the steps of a) reforming the carbonaceous containing feedstock into a first product stream comprising carbon dioxide, carbon monoxide and hydrogen; b) fermenting the first product stream with an acetogenic anaerobic bacteria to produce a second product stream comprising ethanol; c) concentrating ethanol from the second product stream into a third product stream and; d) dehydrating ethanol in the third product stream to produce ethylene. | 2013-08-29 |
20130224809 | Diterpene Synthases And Method For Producing Diterpenoids - Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof. | 2013-08-29 |
20130224810 | ENHANCED PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES BY RECOMBINANT MICROORGANISMS - The present invention provides for the improved production of fatty acid products in a recombinant microorganism or host cell engineered to express a non-native gene encoding a thioesterase and a non-native gene encoding a lysophosphatidic acid acyltransferase (LPAAT), in which the LPAAT is overexpressed in the recombinant microorganism compared to an otherwise identical microorganism that does not include the non-native LPAAT gene. The invention also provides methods of producing fatty acid products using such recombinant microorganisms. | 2013-08-29 |
20130224811 | FOUR-GENE PATHWAY FOR WAX ESTER SYNTHESIS - The invention relates to methods for producing a wax ester in recombinant host cells engineered to express a thioesterase, an acyl-CoA synthetase, an alcohol-forming fatty acyl reductase, and a wax ester synthase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, recombinant host cells expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, and systems for producing a wax ester via a pathway using these four enzymes, are also provided. | 2013-08-29 |
20130224812 | Process for Resolving Cyclopropyl Diesters - The present disclosure provides a method for the stereospecific hydrolysis of racemic 1,1-dialkyloxycarbonylcyclopropanes. | 2013-08-29 |
20130224813 | PROCESS FOR POLYLACTIC ACID PRODUCTION USING MONASCUS - A process for producing polylactic acid (PLA) comprising the steps: fermenting in a fermentation vessel a micro-organism of the genus | 2013-08-29 |
20130224814 | ANTIMICROBIAL METHOD FOR FERMENTATION PROCESSES - A system and method for controlling bacteria, especially lactic and acetic acid bacteria in the production of ethanol using an organic oxidizing compound in combination with an inorganic oxidizer is provided. Particularly, a mixture of one or more peroxy acids and one or more peroxide compounds is introduced into a fermentation mash so as to inhibit or reduce levels of bacteria that compete with yeast for the fermentation sugars. The peroxy acid and peroxide compounds largely are consumed during the fermentation process and are generally not present in the fermentation by-products, especially recovered distiller's grains. | 2013-08-29 |
20130224815 | METHOD FOR PRODUCING ETHANOL USING RECOMBINANT YEAST STRAIN - This invention provides a method for improving the xylose-metabolizing ability of a yeast strain having xylose-metabolizing ability. The method comprises steps of: soaking the yeast strain having xylose-metabolizing ability in an acetic-acid-containing solution; and then, culturing the yeast strain in a xylose-containing medium to perform ethanol fermentation. | 2013-08-29 |
20130224816 | CONTINUOUS PROCESS FOR CONVERSION OF LIGNIN TO USEFUL COMPOUNDS - This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles. | 2013-08-29 |
20130224817 | Filamentous Fungi and Methods for Producing Isoprenoids - The present invention relates to the production of a isoprenoid products from a lignocellulosic feedstock. Specifically at least triple mutant of filamentous fungi having the isoprenoid pathway results in production of isoprenoid products in commercial quantities. One embodiment of the invention relates to producing the isoprenoid products at the site of the lignocellulosic feedstock to reduce costs of shipping the feedstock. | 2013-08-29 |
20130224818 | METHOD FOR PREPARING A HYDROCARBON - A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-ACP, or a fatty acyl-CoA or a mixture of any of these, to obtain a fatty aldehyde; and contacting the fatty aldehyde with at least one aldehyde decarbonylase enzyme. | 2013-08-29 |
20130224819 | METHODS AND APPARATUSES FOR PRODUCING BIOGASES - There are provided methods for producing at least one biogas comprising submitting an organic material to an anaerobic digestion process in an apparatus effective for carrying such a process so as to produce the at least one biogas, pressurizing the produced at least one biogas, and using the at least one biogas for conveying the organic material through the apparatus. Apparatuses for producing at least one biogas are also disclosed. | 2013-08-29 |
20130224820 | COMPOSITION - There is provided an anti-fouling composition comprising (i) a surface coating material; (ii) an enzyme obtained or obtainable from a marine organism; and (iii)(a) a substrate for the enzyme; and/or (b) a precursor enzyme and a precursor substrate, wherein the precursor enzyme and the precursor substrate are selected such that a substrate for the enzyme is generatable by action of the precursor enzyme on the precursor substrate; wherein the enzyme and the substrate are selected such that an anti-foulant compound is generatable by action of the enzyme on the substrate. | 2013-08-29 |
20130224821 | Light-Activated Chimeric Opsins and Methods of Using the Same - Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons. | 2013-08-29 |
20130224822 | MODIFICATION OF MICROALGAE FOR MAGNETIC PROPERTIES - Genetically engineered algae strains for biofuels and bioproduct production have improved iron utilization including iron uptake and storage, and exhibit improved growth characteristics, magnetic separation, and magnetic hysteresis induced cell lysis. Pond production algal strain embodiments with high iron scavenging capabilities limit iron availability to contaminating microorganisms and invading species. Accumulation of high iron and other paramagnetic elements content in the form of ferritin enhances the cells magnetic susceptibility improving efficiency of magnetic separation and magnetic hysteresis induced cell lysis. Several genes of the embodiments are capable of improving iron acquisition including the ferritin gene fer1, iron transport gene fea1, and iron reductase gene fre1. Other genes which improve growth in the high iron conditions permitting higher accumulation of iron include radical scavenging enzymes such as superoxide dismutase, peroxidase, catalase, glutathione peroxidase and the Ferritin like DPR/DPS genes which also bind iron and protect DNA from reactive oxygen species. | 2013-08-29 |
20130224823 | MAGNETIC GLASS PARTICLES FOR USE IN BIOGAS PLANTS, FERMENTATION AND SEPARATION PROCESSES - A method for treating an organic and/or inorganic substrate utilizing a granular material made of a solid foam as support for an active component, for example a biocatalyst such as a microorganism or an enzyme. The solid foam has a continuous phase in which magnetizable particles are embedded, such that the support with the biologically active component immobilized thereon can be separated from a mixture with a magnetic separation device. | 2013-08-29 |
20130224824 | ELECTRODE HAVING ENZYME CRYSTALS IMMOBILIZED THEREON, METHOD FOR PRODUCING ELECTRODE HAVING ENZYME CRYSTALS IMMOBILIZED THEREON, AND BIOLOGICAL FUEL CELL AND BIOSENSOR PROVIDED WITH ELECTRODE HAVING ENZYME CRYSTALS IMMOBILIZED THEREON - An objective of the present invention is to establish a technique for making it possible to immobilize an enzyme on an electrically conductive base material in a uniformly, high density, and constantly aligned orientation, for the purpose of constructing an enzyme electrode having improved electrode performance. An electrode having enzyme crystals immobilized thereon, the electrode being provided with an electrically conductive base material that can be connected to an external circuit and enzyme crystals that serve as an electrode catalyst, wherein the enzyme crystals are immobilized on the electrically conducive base material; a method for producing an electrode having enzyme crystals immobilized thereon; and a biological fuel cell and a biosensor which are provided with an electrode having enzyme crystals immobilized thereon. | 2013-08-29 |
20130224825 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 2013-08-29 |
20130224826 | BIOACTIVE COMPOSITION INCLUDING STABILIZED PROTEIN AND PROCESS FOR PRODUCING THE SAME - A bioactive composition includes a porous hydrogel matrix. At least one protein is immobilized in the porous hydrogel matrix forming a hydrogel protein composite that is stable in an organic solvent. A process for stabilizing a bioactive composition includes the steps of: forming hydrogel matrix pores around protein molecules and reducing water content within the hydrogel matrix pores forming a hydrogel protein composite that is stable in an organic solvent. | 2013-08-29 |
20130224827 | ENDOTHELIAL NITRIC OXIDE SYNTHASE - The activity of endothelial nitric oxide synthase (eNOS) was modulated by contact with an effective amount of a mitogen-activated protein (MAP) kinase, resulting in phosphorylation of S602, T46, and/or S58. Kinetics and stoichiometry are disclosed. The contact strongly reduced nitric oxide (NO) synthesis, and also inhibited the cytochrome c reductase activity of eNOS reductase domains. Three sites of phosphorylation were determined that matched the serine-proline (SP) and threonine-proline (TP) motifs of typical MAP kinase phosphorylation sites. | 2013-08-29 |
20130224828 | RNA-Directed Packaging of Enzymes Within Protein Particles - Protein nanoparticles encapsulate cargo proteins within an enclosure containing a protected chemical milieu. Encapsulation within such protected chemical milieu enhances the employability and performance of cargo proteins, particularly cargo enzymes, particularly within otherwise hostile chemical environments. Protein nanoparticles are assembled using shell proteins, such as viral coat proteins like Qβ, in the presence of a bifunctional polynucleotide and the selected cargo protein. The bifunctional polynucleotide includes two aptameric activities that assist the disposition and retention of cargo proteins within the protein nanoparticle. | 2013-08-29 |
20130224829 | NOVEL LIPOXYGENASE DERIVED FROM LEMNA PAUCICOSTATA - A highly active novely lypoxygenase cDNA derived from Lemna paucicostata SH strain and Lemna paucicostata 441 strain and a protein encoded by the cDNA are provided. | 2013-08-29 |
20130224830 | EGGSHELL MEMBRANE SOLUBILIZATION METHOD USING ENZYMES - The present invention addresses the problem of providing an eggshell membrane solubilization method that is capable of solving the problems associated with carrying out treatment using acids and alkalis, or problems associated with the processing methods of the conventional art that use proteases; in other words, an eggshell membrane solubilization method that is capable of solving at least one of the following problems: (1) the need for pretreatment such as pulverization, sonication or boiling; (2) the need for prolonged treatment; and (3) a low decomposition rate (approximately 20%). Eggshell membranes are efficiently solubilized by using a protease in combination with a reducing agent. | 2013-08-29 |
20130224831 | Dish Detergent Comprising Bleaching Enzymes - Described are compositions and methods that involve using bleaching enzymes in dish detergents. In some preferred embodiments, the bleaching enzyme comprises at least one laccase, while in some alternative preferred embodiments, the bleaching enzyme comprises at least one glucose oxidase suitable for use in dish detergents. In some additional preferred embodiments, the dish detergents are machine dish detergents. | 2013-08-29 |
20130224832 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e−02. | 2013-08-29 |
20130224833 | Method for Preparing and Using Cell Extract Solution for Tubulin-free Cell-free Protein Synthesis and Reagent Kit for Cell-free Protein Synthesis - A method is provided for preparing cell extract solution for cell-free protein synthesis that can effectively remove tubulin protein, a reagent kit for cell-free protein synthesis including the extract solution, and a method for synthesizing cell-free protein using the extract solution. The method for preparing cell extract solution for cell-free protein synthesis includes the steps of: obtaining an extraction treated material of cultured cells by subjecting the cultured cells to an extraction treatment using an extraction buffer; obtaining a reaction mixture by subjecting the extraction treated material to tubulin polymerization reaction and polymerizing the tubulin derived from the culture cells included in the extraction treated material; and preparing the cell extract solution for cell-free protein synthesis by subjecting the reaction mixture to removal of the polymerized tubulin and a buffer exchange. | 2013-08-29 |
20130224834 | ANTI-ANDROGENIC AGENT, SEBUM SECRETION BLOCKER, HAIR GROWTH STIMULANT, AND FOOD OR BEVERAGE - Provision of an anti-androgenic agent which has a strong anti-androgenic action, is free of side effects and very safe, and a sebum secretion blocker and a hair growth stimulant containing the anti-androgenic agent as an active ingredient. Provided are the anti-androgenic agent comprising lactoferrin, the sebum secretion blocker containing the anti-androgenic agent as an active ingredient, the hair growth stimulant containing the anti-androgenic agent as an active ingredient, and a food or drink product comprising the anti-androgenic agent containing lactoferrin as an active ingredient. | 2013-08-29 |
20130224835 | RADIOLABELLING METHODS - The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): | 2013-08-29 |
20130224836 | Adeno-Associated Virus Virion for Gene Transfer to Nervous System Cells - The present invention provides a means for transferring a therapeutic gene of interest into a nervous system cell by a highly-efficient and simpler means. More specifically, the present invention provides a recombinant vector that uses an adeno-associated virus (AAV), a method for manufacturing the recombinant vector, and a method for using the recombinant vector. More specifically, recombinant adeno-associated virus virions, which are capable of passing through the brain-brain barrier, for transferring a therapeutic genes of interest into a nervous system cell in a highly-efficient manner, a drug composition containing the recombinant adeno-associated virus virions, a method for manufacturing the recombinant adeno-associated virus virions, and a kit or the like are provided. | 2013-08-29 |
20130224837 | INOCULATION TOOL AND METHOD OF USE THEREOF - The present invention describes disposable inoculation tools designed to fit into an appropriately sized test tube with the lid closed. A method that reduces the overall number of steps required to complete inoculation and can reduce repetitive motion injuries that might result from repetitive inoculation is also disclosed. | 2013-08-29 |
20130224838 | RECOMBINANT MICROORGANISMS AND USES THEREFOR - The invention provides, inter alia, methods for the production of acetone, isopropanol and/or precursors of acetone and/or isopropanol by microbial fermentation of substrates comprising CO, genetically modified microorganisms of use in such methods, nucleic acids suitable for preparation of genetically modified microorganisms, a novel alcohol dehydrogenase and nucleic acids encoding same. | 2013-08-29 |
20130224839 | Recombinant Microorganism and Methods of Production Thereof - The invention relates to a recombinant carboxydotrophic acetogenic microorganism capable of producing one or more products by fermentation of a substrate comprising CO, wherein the microorganism has an increased tolerance to ethanol versus a parental carboxydotrophic acetogenic microorganism. The invention also provides, inter alia, methods for the production of ethanol and one or more other products from a substrate comprising CO using the recombinant carboxydotrophic acetogenic microorganism. | 2013-08-29 |
20130224840 | Fabricated Panel - The product is made, in part, of a network of interconnected mycelia cells forming a mass. In one embodiment, the mass includes one or more embedded elements, such as a panel. In another embodiment, the mass is formed over a three-dimensional lattice. The mycelia cells form hyphae that bond directly to panels made of cellulosic materials. | 2013-08-29 |
20130224841 | METHOD FOR ESTABLISHING SYNERGISM BETWEEN RENEWABLE ENERGY PRODUCTION AND FOSSIL ENERGY PRODUCTION - A method and system for synergism between a renewable energy system and a fossil energy system for the production of marketable energy forms. Fossil-energy-assisted, renewable energy production or renewable-energy-assisted, fossil energy production uses coal, hydrocarbon fuel oil, or natural gas as the fossil energy source. The renewable energy is from the cultivation of microalgae and the extraction of its oil content, production of methane, and coincidentally-produced oxygen. The products and by-products from the fossil energy production are used for the cultivation of algae and the products and by-products from algae cultivation are used to reduce the consumption of fossil energy in the energy production. The synergism is the interchange of these products and by-products such that the net marketable energy production results in maximizing the use of renewable (solar) energy, minimizing the use of fossil fuel, and minimizing emissions of carbon dioxide to the atmosphere. | 2013-08-29 |
20130224842 | PROCESS FOR CO2 ABSORPTION WITH CARBONIC ANHYDRASE ENTRAPPED IN POROUS SUPPORTS - A carbonic anhydrase bioreactor for treating a CO | 2013-08-29 |
20130224843 | EFFICIENT HAPLOID CELL SORTING FLOW CYTOMETER SYSTEMS - A flow cytometry system ( | 2013-08-29 |
20130224844 | STRUCTURED POLYDIORGANOSILOXANE POLYAMIDE CONTAINING DEVICES AND METHODS - Devices including a polydiorganosiloxane polyamide containing material having a microstructured surface are disclosed herein. Such devices can optionally include a flex circuit attached to the microstructured surface and can be useful, for example, in fluid handling applications. | 2013-08-29 |
20130224845 | FLUID INTERFACE CARTRIDGE FOR A MICROFLUIDIC CHIP - An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip. | 2013-08-29 |
20130224846 | Universal Sample Preparation System and Use in an Integrated Analysis System - The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft | 2013-08-29 |
20130224847 | OPTICAL HEADS AND SEQUENCING APPARATUSES INCLUDING THE SAME - A sequencing apparatus may include a bio-disk having reaction regions in which nucleic acids are polymerized; a stage configured to revolve around an axis, the stage including optical heads for detecting lights emitted from the plurality of reaction regions due to the polymerization of the nucleic acids; and/or a control unit configured to generate data regarding base sequences of the nucleic acids in the reaction regions based on wavelengths of the lights detected by the plurality of optical heads. An optical head may include a light emitting unit configured to emit light toward a reaction region in which nucleic acids are polymerized; a light receiving unit configured to receive the light emitted by the light emitting unit; a de-multiplexing unit configured to de-multiplex the light received by the light receiving unit; and/or a plurality of photoelectric converting units configured to convert the de-multiplexed light to electrical signals. | 2013-08-29 |
20130224848 | Device and Method for Detection and Quantification of Immunological Proteins, Pathogenic and Microbial Agents and Cells - The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD | 2013-08-29 |
20130224849 | BIOLOGICAL STERILIZATION INDICATOR - A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity. | 2013-08-29 |
20130224850 | Device and method for detecting bacterial endospores that are suspended in the atmosphere - A device that detects bacterial endospores suspended in the atmosphere is provided. The device having an aerosol concentrator, a collection vessel containing a lanthanide salt solution, an excitation energy source and an optical set-up that directs the excitation energy source to the lanthanide salt solution and collects photoluminescence generated by the lanthanide salt solution upon receipt of the excitation energy source. A system and method for detecting bacterial endospores is also disclosed. | 2013-08-29 |
20130224851 | SYSTEM, APPARATUSES AND DEVICES FOR PRETREATING CELLS - The present invention provides a system and apparatuses/devices capable of automatically performing the processes of cell treatment preparatory to flow cytometry and similar cytological studies in a fully automated and streamlined manner. The system and apparatuses/devices are being adapted for preparation and (pre)processing of cell samples, e.g. blood and/or bone marrow samples. | 2013-08-29 |
20130224852 | HIGH SOLIDS ENZYME REACTOR OR MIXER AND METHOD - A reactor apparatus including: an internal mixing chamber including a first chamber section having a cross-sectional area expanding from a biomass inlet to the internal mixing chamber to the a second chamber section; the second chamber section having a substantially uniform internal cross-sectional area from the opposite end of the first chamber section to a discharge end of the mixing chamber; the biomass inlet is coupled to a source of pre-treated biomass external to the reactor vessel, and a rotating mixing device in the internal mixing chamber and coaxial with an axis of the first chamber section. | 2013-08-29 |
20130224853 | Solar Biofactory, Photobioreactors, Passive Thermal Regulation Systems And Methods for Producing Products - The invention described herein relates to photobioreactors, methods, assembly and use of such apparatus for culturing light-capturing organisms in a cost-effective manner. Various embodiments provide for a passive thermal regulation system employing selected microorganisms in a photobioreactor apparatus and methods for biological production of various fuel and chemical products from these organisms. Additional embodiments provide a solar biofactory system capable of culturing light capturing organisms to an areal productivity of 3.3 g/m2/hr. Further embodiments are directed to a photobioreactor capable of culturing light capturing organisms to an OD | 2013-08-29 |
20130224854 | ANTI-SINGLE-CHAIN TYPE IV COLLAGEN POLYPEPTIDE ANTIBODY, PHARMACEUTICAL DRUG, DIAGNOSTIC, PREVENTIVE, OR THERAPEUTIC DRUG FOR TUMOUR CONTAINING THE ANTIBODY - A monoclonal antibody, wherein the monoclonal antibody specifically binds to a single-chain type IV collagen polypeptide, and wherein the monoclonal antibody is obtained by a hybridoma line of Anti NK-Antigen monoclonal antibody #141 having Accession No: FERM BP-11300. | 2013-08-29 |
20130224855 | CULTURE MEDIUM FOR EUKARYOTIC CELLS - The invention pertains to the use of amino acid derivatives selected from N-acetyl amino acids, γ-glutamyl amino acids, pyroglutamyl amino acids, glutamate-containing or proline-containing dipeptides, oxo-aminoacids, homo-aminoacids, and glycyl-glycine, as a growth- and production promoting ingredient, in culture media for culturing eukaryotic cells. The invention further pertains to culture media containing these amino acid derivatives at levels of at least 0.001 mg/l. | 2013-08-29 |
20130224856 | LARGE-SCALE PROPAGATION AND MAINTENANCE METHOD OF EMBRYOID BODIES GENERATED FROM STEM CELLS - The present invention relates to a large-scale propagation and maintenance method of embryoid bodies generated from stem cells. More particularly, the present invention relates to a large-scale propagation and maintenance method of embryoid bodies retaining their intrinsic characteristics for a long period of time, comprising the step of continuously subculturing embryoid bodies that are primarily produced from embryonic stem cells or from induced pluripotent stem cells. According to the method of the present invention, after preparation of embryoid bodies from a limited number of stem cells, large-scale production and maintenance of embryoid bodies can be realized by a simple mechanical subculturing method without the continuous supply of stem cells. | 2013-08-29 |
20130224857 | METHOD OF DIFFERENTIATING STEM CELLS - The present disclosure provides methods of generating germ layers from stem cells comprising culturing the stem cells in a culture media having osmolality ranges that promote the generation of specific germ layer progenitor cells. The present disclosure also includes a method to generate different cell lineages from the germ layers as well as to detect them by immunological methods. The present disclosure further provides methods for the generation, isolation, cultivation and propagation of committed progenitor cells and for the production of differentiated cells from the three germ layers. The present disclosure also provides culture media and kits for use in inducing the three germ layers. | 2013-08-29 |
20130224858 | ADIPOSE-DERIVED STEM CELLS AND LATTICES - The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures. | 2013-08-29 |
20130224859 | DNA ORIGAMI DEVICES - Provided herein are DNA origami devices useful in the targeted delivery of biologically active entities to specific cell populations. | 2013-08-29 |
20130224860 | THREE-DIMENSIONAL FIBROUS SCAFFOLDS FOR CELL CULTURE - Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein. | 2013-08-29 |
20130224861 | METHOD FOR MANUFACTURING CELL CULTURE SUBSTRATE - A method for manufacturing a cell culture substrate obtained by forming a coating layer of a polymer on the surface of a substrate, wherein the polymer is formed by polymerizing a monomer component containing a nitrogen atom-containing monomer represented by formula (I): | 2013-08-29 |
20130224862 | COATINGS AND CULTURE MEDIA FOR PROMOTING NEUROGENESIS IN ADIPOSE TISSUE DERIVED STEM CELLS - Provided herein are coatings for stem cell cultureware comprising poly-L-ornithine and bovine fibronectin and methods for preparing coated stem cultureware comprising contacting cultureware with poly-L-ornithine and contacting the cultureware with bovine fibronectin. Also provided are stem cell culture media comprising epidermal growth factor, beta-fibroblast growth factor and N2 supplement. | 2013-08-29 |
20130224863 | RATIONALLY-DESIGNED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN DNASE HYPERSENSITIVE REGIONS OF THE HUMAN GENOME - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 2013-08-29 |
20130224864 | FILAMENTOUS FUNGI HAVING AN ALTERED VISCOSITY PHENOTYPE - Described are compositions and methods relating variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications. | 2013-08-29 |
20130224865 | ANTI-MICROBIAL BIOTHERAPEUTIC AGENTS: ALTERNATIVES TO CONVENTIONAL PHARMACEUTICAL ANTIBIOTICS - Novel antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill targeted pathogenic bacteria, but are not harmful to donor bacteria. Two types of lethal transmissible plasmids are disclosed. One type kills recipient bacteria by unchecked (“runaway”) replication in the recipient cells and is prevented from occurring in donor cells. Another type kills recipient bacteria by expressing a gene that produces a product detrimental or lethal to recipient bacterial cells, that gene being prevented from expression in donor cells. | 2013-08-29 |
20130224866 | MEDICAL FLUID ACCESS DEVICE WITH ANTISEPTIC INDICATOR - A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent. The indicator includes a substrate and a microporous layer disposed on the substrate. The microporous layer is made from a polymer material having an index of refraction from about 1.25 to about 1.6 and is configured to change from a substantially opaque state to a substantially transparent state upon exposure to an antiseptic solution. The microporous layer resumes the substantially opaque state after a period of time. | 2013-08-29 |
20130224867 | METHOD AND SYSTEM FOR DETECTING CORROSION OF AN INSULATED CORROSION PRONE OBJECT - Corrosion Under Insulation (CUI) of an insulated iron or other corrosion prone object ( | 2013-08-29 |
20130224868 | Closure with Septum Strip - A closure is described for a container containing a reagent. The closure includes a cover. The cover includes at least two through bore holes. The closure further includes a strip which includes a base and at least two septa. The base is of a stiff material and the septa is of a flexible material. The septa are attached to one surface of the base. Each septum includes a pre-slit bottom and a barrel forming the sides of the septum. The outer diameter of each septum barrel is larger than the inner diameter of the through bore hole such that a pressure is exerted on the septum when the septum is press fitted into the through bore hole. | 2013-08-29 |
20130224869 | IMAGING SYSTEM AND ASSOCIATED METHOD FOR DETECTION OF PROTEIN CONTAMINATION - An imaging system ( | 2013-08-29 |
20130224870 | FLUORESCENCE LABELING REAGENTS AND USES THEREOF - Solid phase fluorescent labeling reagents (SPR) are described that simultaneously capture and label analytes, and then efficiently release the labeled-analytes under mild conditions (SCaLER). | 2013-08-29 |
20130224871 | Novel Amine-Substituted Tricyclic Fluorescent Dyes - The present invention relates to polycyclic compounds of the general formula (I) which are distinguished by an amine substituent NR | 2013-08-29 |
20130224872 | Apparatus and Methods for Detecting Propellant Degradation in Solid Propellant Fuel - The present disclosure relates to a gas sensor, including: a gas collecting chamber including: (a) a nanoporous wall including alumina, on a portion of the gas collecting chamber in the near vicinity of the solid propellant fuel; a micro pump attached to the gas collecting chamber; and a gas analysis device connected to the gas collecting chamber. The gas analysis device measures both type and concentration of gases collected in the gas collecting chamber via the nanoporous wall, the gases measured being selected from the group consisting of CO, CO | 2013-08-29 |
20130224873 | METHOD AND DEVICE FOR THE DETECTION OF SULPHUR CONTAINING SPECIES - A method is provided for detecting sulphur-containing species (such as thiophosphorous esters, in particular phosphorylating agents), in which a suspected sulphur-containing species is brought into contact with a tetrazolium compound in the presence of base, typically at a pH of at least 8. A device, kit and tetrazolium compounds for use in such a method are also disclosed. | 2013-08-29 |
20130224874 | Phosphorescent Molecules for Measuring Oxygen and Imaging Methods - Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a “next generation” of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing. Additional methods are provided for structurally modifying the dendrimer used to encapsulate the porphyrin phosphor to provide internal quenching of singlet oxygen molecules formed during oxygen measurements. | 2013-08-29 |
20130224875 | TIME-TEMPERATURE INDICATING DEVICE - The present invention is generally in the field of measuring and indicating techniques and relates to a time-temperature indicating device and methods of manufacturing and reading this device. More specifically, the time-temperature indicator (TTI) device comprises at least one active reactant being at least a part of a component that is configured to be either an electrical component or transformable into an electrical component, said at least one active reactant being selected to be affectable by a chemical and/or physical reaction effecting a change in at least an electrical property of said electrical component at a rate that is time-temperature dependent. | 2013-08-29 |
20130224876 | A METHOD AND DEVICE FOR DETECTING ALKYLATING AGENTS - A method is provided for detecting alkylating agents, the method comprising bringing together a first solvent, one or more surfactants, a base, a reagent comprising a nucleophilic nitrogen atom, and a suspected alkylating agent. A device suitable for putting said method into effect is also provided. | 2013-08-29 |
20130224877 | LUMINESCENCE REFERENCE STANDARDS - The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis. | 2013-08-29 |
20130224878 | BIOCHIP WELL, SEALED WELL ASSEMBLY, CARTRIDGE THEREFOR, AND APPARATUS AND METHODS FOR OPENING SEALED WELLS - A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells. | 2013-08-29 |
20130224879 | SYSTEMS AND METHODS FOR A DNA-BASED THERMOMETER - DNA-based temperature sensor for measuring temperature through a transition of one or more strands of DNA from a coupled configuration to a decoupled configuration at a temperature threshold, and a fluorescent dye adapted to emit fluorescence when the DNA is in the coupled configuration, includes a receptacle adapted to receive the DNA and the fluorescent dye in a solution, an imaging device adapted to acquire an image of fluorescence emitted from the solution, the image having a plurality of regions, and a processor adapted to determine a plurality of fluorescence levels corresponding to each of the plurality of regions of the image and to generate a temperature map based on the determined fluorescence levels. A method for measuring temperature and a DNA-based temperature sensing solution are also provided. | 2013-08-29 |
20130224880 | REAGENTS AND METHODS FOR DETECTING PROTEIN CROTONYLATION - The invention provides an isolated peptide comprising a crotonylation site, a Kcr-specific affinity reagent that specifically binds to the peptide, and a method for detecting protein crotonylation in a sample using the reagent. | 2013-08-29 |
20130224881 | POLYROTAXANES AND USES THEREOF - A polyrotaxane containing an affinity binding group has been designed and prepared. The polyrotaxane of the invention can be used for characterization and determination of the three-dimensional structures of biological molecules, such as proteins. | 2013-08-29 |
20130224882 | Assay for the Detection of the Phenylpiperazine Family - The current invention describes novel immunogens which are used in the production of novel antibodies with unique binding properties in that they cross-react with a variety of phenylpiperazine derivatives. These antibodies enable methods and kits to detect and/or determine phenylpiperazine derivatives (for example mCPP, TFMPP and MeOPP) in an in vitro sample which are advantageous over currently available analytical methods in terms of cost, ease of use, speed and sensitivity. | 2013-08-29 |
20130224883 | Method for recognizing interferences in in vitro diagnostic assays - The present invention is in the field of in vitro diagnostics and relates to a method for recognizing interfering disruptive factors, such as heterophile antibodies or rheumatoid factors for example, in a sample. | 2013-08-29 |
20130224884 | DEVICE AND METHOD FOR IMMUNOASSAYS - A device for performing a test to determine the presence or the absence of at least one analyte in a liquid sample includes: a support and a matrix, fixed on the support. The matrix includes: a liquid sample application zone, a marking zone and at least one reaction zone. The one reaction zone includes: a test results display zone having at least a second immobilized binding partner which is able to bind to at least one analyte, and a monitoring zone downstream of the results display zone or parallel with the results display zone which allows monitoring of the correct functioning of the device and which includes at least one analogue of the at least one analyte which is able to bind to at least a first marked binding partner. The liquid sample application zone, marking zone and reaction zone are in fluid communication. | 2013-08-29 |
20130224885 | BLUE-COLORED GOLD NANOPARTICLES FOR IMMUNOLOGICAL MEASUREMENT, PROCESS FOR PRODUCTION OF SAME, AND MEASUREMENT METHOD USING SAME - Gold nanoparticles which comprises organic buffer containing a piperazine ring, gold, and an organic acid having reducing properties and which shows a blue color by visually view when it is dispersed as a colloidal solution, can be produced easily by conducting a nucleus formation step by reacting organic acid containing a piperazine ring with a solution of a first gold salt to form nucleus gold nanoparticles and a growth step by simultaneously adding and reacting a solution of a second gold salt and an organic acid having reducing properties with a solution of the nucleus gold nanoparticle to grow the nucleus gold nanoparticles. The produced gold nanoparticles can be used as labeling particles in an immunological measurement method. | 2013-08-29 |
20130224886 | FLOW RATE MEASUREMENT APPARATUS, ANTIGEN CONCENTRATION MEASUREMENT APPARATUS, FLOW CELL, FLOW RATE MEASUREMENT METHOD, AND ANTIGEN CONCENTRATION MEASUREMENT METHOD - A flow rate measurement apparatus includes a light oscillator; a thin metallic film which causes surface plasmon resonance by light output from the light oscillator; a focusing unit which fixes the thin metallic film and converts the output light of the light oscillator into incident light having a plurality of incident angles to focus the incident light at a location of a focal line in a straight line shape on the thin metallic film; a measurement part having antibody fixed areas to which an antibody is fixed and reference areas to which an antibody is not fixed, the antibody fixed areas and the reference areas being alternately arranged at a location along the focal line location on the thin metallic film; a light receiver which receives reflected light, at the focal line location, of the output light by surface plasmon resonance occurring at the focal line location, at each of the plurality of incident light angles; an SPR angle calculator which obtains a temporal change of an SPR angle in each of the antibody fixed areas and the reference areas in the measurement part; and a flow rate operation unit which calculates the flow rate of the sample flowing in the flow cell based on the temporal change of the SPR angle obtained by the SPR angle calculator. | 2013-08-29 |