35th week of 2013 patent applcation highlights part 52 |
Patent application number | Title | Published |
20130224685 | DENTAL POSITIONING STENT, AND MANUFACTURING METHOD, USING METHOD AND COMPONENTS FOR THE SAME - A dental positioning stent for drilling an implant hole and a manufacturing method, a using method and components for the same are provided. The manufacturing method includes: slicing a tooth mold and a false tooth model along a preset slice plane; fixing two markers in the preset slice plane on two sides of the false tooth model respectively; covering the markers and the false tooth model with a shaping agent to form a positioning stent; putting the positioning stent on the teeth in a mouth to perform tomography imaging to acquire a slice image of the preset slice plane; mounting a positioning aid having a positioning hole in the positioning stent according to the slice image pasted up on the tooth mold to guide an initial drill. A dental positioning stent for tomography imaging, and a manufacturing method, a using method, and components thereof are provided. | 2013-08-29 |
20130224686 | DENTAL RETENTION SYSTEMS - Dental retention systems which facilitate the adjustment or removal of an oral appliance. e.g., a crown or bridge, from a reconfigurable abutment assembly are described. The adjustable abutment assembly may be secured to an anchoring implant bored into the bones within the mouth. The abutment assembly has a projecting abutment portion with one or more shape memory alloy compression plates or elements extending along the projecting abutment portion. Each of the plates has a length with one or more straightened portions and with at least one curved or arcuate portion. Energy may be applied to the elements such that the arcuate portion self-flattens to allow for the oral appliance to be placed thereupon while removal of the energy allows the elements to reconfigure into its curved configuration thereby locking the oral appliance to the abutment. Removal of the oral appliance may be effected by reapplication of energy to the elements. | 2013-08-29 |
20130224687 | DENTAL IMPLANT - A dental implant that facilitate insertion and can be used in all bone types. The implant includes a body having a coronal end, and an apical end opposite the coronal end. A tapered region may be adjacent the apical end. On the apical part two or more taps are provided. The first tap is a condensing tap and the second tap is a cutting tap. The implant can have at least one variable profile helical thread that extends along the tapered region. The implant can have also micro-threads below the main threads, a gradual compressing tapered core, a self drilling apical end and a narrow coronal region. | 2013-08-29 |
20130224688 | PROCESS FOR PRODUCING A DENTAL ARTICLE, ARTICLE OBTAINABLE BY THIS PROCESS AND USES THEREOF - In one aspect the present disclosure relates to a process for producing a dental article comprising at least two parts, Part A (e.g. coping) and Part B (e.g. veneer), Part A and Part B each having a 3-dim. structure and an outer and an inner surface, the outer surface of Part A having a shape which essentially corresponds to the shape of the inner surface of Part B, Part B comprising a material with a porous section and being produced with the aid of a rapid-prototyping technique, the process comprising a first heating step, wherein Part A is serving as support structure for Part B during said heating step. | 2013-08-29 |
20130224689 | IMPLANT, IMPLANT BODY, AND ABUTMENT BODY - An implant that includes an implant body in which a fitting hole portion having a taper shape is formed, and an abutment having a fitting shaft portion having a taper shape. A pressure-withstanding mechanism configured by the fitting hole portion and the fitting shaft portion and a rotation-preventing mechanism preventing rotation of the abutment with respect to the implant body are integrally formed. | 2013-08-29 |
20130224690 | MICROBEADS FOR DENTAL USE - A method for decreasing dental hypersensitivity, including sizing a plurality of non-functionalized microbeads to be between 0.01 μm to 3 μm in diameter, suspending the plurality of non-functionalized microbeads in a fluid matrix to define a dental delivery composition, introducing the dental delivery composition into an oral cavity, introducing respective non-functionalized microbeads into a dental tubule, adhering respective functionalized microbeads each other and to the dental tubule to define an aggregate, and occluding the dental tubule with the aggregate. | 2013-08-29 |
20130224691 | Dental Appliance - An appliance fabricated to improve the appearance of a patient's smile includes a plurality of simulated teeth. The interior surfaces of each of the teeth closely fits and conforms to the surface of a patient's real teeth while the outer surfaces of each of the simulated teeth has an ideal surface configuration. The dental appliance provides the patient with the appearance of a perfect set of teeth and an ideal smile without a need to alter the dental structure of the patient's teeth. | 2013-08-29 |
20130224692 | ADHESIVE COMPOSITION SUITABLE FOR DENTAL USES - A dental adhesive composition is described comprising a photocurable ionomer, radiopaque metal oxide nanoparticles, a phosphorous-containing acidic monomer, other polymerizable resin components, and a polar solvent. In a favored embodiment, the adhesive composition comprises a photocurable ionomer in an amount up to 15 wt-%; 5 wt-% to 30 wt-% of radiopaque metal oxide nanoparticles that comprise a basic surface (such as zirconia) wherein the nanoparticles comprise an organosilane surface treatment; a phosphorous-containing acidic monomer in an amount up to 10 wt-%; and 10 wt-% to 50 wt-% of solvent comprising water and at least one alcohol, ketone, or mixture thereof. | 2013-08-29 |
20130224693 | METHOD OF DETECTION OF USER CONFUSION HAVING FOLLOW-UP INSTRUCTIONS - A method is disclosed for providing instructions to a user of a vehicle wherein the vehicle includes a plurality of sensors and a display screen. Instructions related to a vehicle operation are provided to the user by using the method comprising the steps of sensing by a sensor of a signal containing information regarding a condition indicative of confusion or human trigger of confusion, transmitting the signal containing the information regarding the confusion from the sensor to a processor, and then displaying instructions to the user on the display screen within the vehicle regarding how to remedy the confusion regarding the vehicle operation. The human trigger is sensed by a sensor or a plurality of sensors and includes detection of confusion when the vehicle user is pressing multiple buttons, incorrect buttons, pressing the same button multiple times, or a lack of pressing any buttons or triggers. | 2013-08-29 |
20130224694 | Integrated System and Method for Meal Planning and Management - A computer implemented system and method For familial meal-planning decision support by analyzing user pre-defined inputs of constraints and priorities, reflecting their individual family size, nutritional concerns, tastes, as well as the user's constraints on time, budget, interest in experimentation, and variety, store preferences, etc. The software engine maps the user-defined inputs against local store sales, promotions, and/or manufacturer offers, and compiles a suggested periodic meal and shopping plan and, if accepted, shopping list by store organized by aisle or delivery order). The system is customizable and employs artificial intelligence to learn from user feedback and scoring as well as comparisons to other similar families | 2013-08-29 |
20130224695 | SYSTEM AND METHOD FOR PROVIDING FLAVOR ADVISEMENT AND ENHANCEMENT - A method and apparatus for generating a visual representation of a flavor or texture profile based on flavor or texture preferences of a user with respect to each of a plurality of flavor or texture categories or based on flavor or texture characteristic information representing flavor or texture characteristics of a product or recipe for each of a plurality of flavor or texture categories. The flavor or texture preferences of a user and the flavor or texture characteristics of a product or recipe with respect to each of a plurality of flavor or texture categories is determined by way of a method and apparatus for determining a flavor or texture profile for a user and a method and apparatus for determining a flavor or texture profile for a food element, respectively. Also described is a method and apparatus for providing food element recommendations based on flavor or texture. | 2013-08-29 |
20130224696 | SYSTEM AND METHOD FOR PROVIDING FLAVOR ADVISEMENT AND ENHANCEMENT - A method and apparatus for generating a visual representation of a flavor or texture profile based on flavor or texture preferences of a user with respect to each of a plurality of flavor or texture categories or based on flavor or texture characteristic information representing flavor or texture characteristics of a product or recipe for each of a plurality of flavor or texture categories. The flavor or texture preferences of a user and the flavor or texture characteristics of a product or recipe with respect to each of a plurality of flavor or texture categories is determined by way of a method and apparatus for determining a flavor or texture profile for a user and a method and apparatus for determining a flavor or texture profile for a food element, respectively. Also described is a method and apparatus for providing food element recommendations based on flavor or texture. | 2013-08-29 |
20130224697 | SYSTEMS AND METHODS FOR GENERATING DIAGNOSTIC ASSESSMENTS - Systems and methods are disclosed to provide educational diagnostic assessment of reading and math performance for a student by receiving a log-in from the student over a network; presenting a new concept to the student through a multimedia presentation; testing the student on the concept at a predetermined testing level; collecting test results for one or more concepts into a test result group; performing a diagnostic analysis of the test result group; and adaptively modifying the predetermined testing level based on the adaptive diagnostic analysis and repeating the process at the modified predetermined learning level for a plurality of sub-tests. | 2013-08-29 |
20130224698 | METHOD, SYSTEM AND APPARATUS FOR EVALUATION OF EMPLOYEE COMPETENCIES USING A COMPRESSION/ACCELERATION METHODOLOGY - A mechanism to evaluate the value of employee competencies across a business entity is provided. Managers provide raw interpretations of employee competencies in a variety of selected competency areas. The raw evaluations of employee competencies are weighted and stored according to an organizational utility of each competency to the business entity, arriving at an adjusted competency value for each competency. Depth of an employee's competency in a particular area is evaluated by selecting the highest adjusted competency value for an employee and then compressing that highest adjusted competency value in order to level initial assessments of an employee's strongest skill This compressed value is augmented by one or more accelerators based upon the assessments of the employee's other competencies. The result is an overall domain competency rating for the employee that can then be used for comparison against other employees in the business entity. | 2013-08-29 |
20130224699 | Predictive Performance Optimizer - A method, apparatus and program product are provided for optimizing a training regimen to achieve performance goals. Historical training data is provided. At least one training regimen is defined. A training objective is selected for at least one training regimen to optimize. The training regimen is optimized by computing an initial training regimen solution and computing a neighbor solution at a distance from the initial training regimen solution. The neighbor solution is compared to the initial training regimen solution. If the neighbor solution is determined to be a better solution than the initial training regimen solution, the initial training regimen solution is replaced with the neighbor solution. The determination occurs using: | 2013-08-29 |
20130224700 | FORCIBLE ENTRY TRAINING DOOR SYSTEM - The present invention relates generally to apparatus for training the art of forcible door entry for emergency personnel such as firefighters and, in particular, a reusable forcible entry door training prop adapted to simulate a locked door and allow individuals to conduct training in forcible entry techniques for different door types and mounting configurations (e.g., opening inward or outward, left hand opening or right band opening, steel jam or wood jams). | 2013-08-29 |
20130224701 | FORCIBLE ENTRY TRAINING DOOR SYSTEM - Apparatus for training the art of forcible door entry for emergency personnel such as firefighters and, in particular, a reusable forcible entry door training apparatus that allows individuals to simulate forcible entry of outward opening metal doors mounted in metal frames. | 2013-08-29 |
20130224702 | Test Pallet Assembly - An optimization engine builds a set of test forms, called a pallet for use in a qualification test setting. The pallet is generated using a optimization engine programmed with constraints and goals for each test form in the pallet and for the pallet in general. A test information floor is set at the cut point of the test which causes test items to be focused at the area of the test where the pass/fail decision is made. Further constraints may be programmed to maximize the item diversity, that is, to spread the use of available test items as uniformly as possible. | 2013-08-29 |
20130224703 | Test Pallet Assembly and Family Assignment - An optimization engine builds a set of test forms, called a pallet for use in a qualification test setting. The pallet is generated using a optimization engine programmed with constraints and goals for each test form in the pallet and for the pallet in general. A test information floor is set at the cut point of the test which causes test items to be focused at the area of the test where the pass/fail decision is made. The test items may be separated into families by assigning test items selected for a test form in each test generation cycle to one of several families. Because each family has unique test items compared to other families, a person re-taking a qualification test from a particular pallet may be given a test form from another family, ensuring that no item from the first administration will appear on the subsequent test. | 2013-08-29 |
20130224704 | Method and System for Behavior Modification and Sales Promotion - A system for behavior modification and sales promotion includes a child computer device having a computer application stored thereon in a non-transitory computer readable memory. The computer application of the child computer device includes a graphical user interface allowing for a child to interact with a fictitious character. A parent computer device is provided having a computer application stored thereon in a non-transitory computer readable memory, the computer application of the parent computer device including a graphical user interface allowing a parent to control the fictitious character with which the child interacts on the child computer device. The system also includes a system server. The parent computer device, the child computer device and system server are connected by a global communication network. | 2013-08-29 |
20130224705 | Method and System for Behavior Modification and Sales Promotion - A system for behavior modification and sales promotion includes a child computer device having a computer application stared thereon in a non-transitory compute readable memory. The computer application of the child computer device includes a graphical user interface allowing for a child to interact with a fictitious character. A parent computer device is provided having a computer application stored thereon in a non-transitory computer readable memory, the computer application of the parent computer device including a graphical user interface allowing a parent to control the fictitious character with which the child interacts on the child computer device. The system also includes a system server. The parent computer device, the child computer device and system server are connected by a global communication network. | 2013-08-29 |
20130224706 | TOY OBJECT AND TASK-CONDITIONAL REWARD - Some embodiments relate to systems and methods for encouraging performance of kind acts. A toy object, a task identifier and a code are simultaneously provided to a user. The task includes an instruction to perform a kind act. Instructions further indicate that a user is to input the code into a website upon completing the identified task. Entry of the code causes a reward (e.g., a virtual reward or physical reward) to be distributed (e.g., to the user or to another party). | 2013-08-29 |
20130224707 | Mixed Martial Arts Kick Training Device - An embodiment of the present invention contemplates a martial arts kick training device that generally includes a belt, an elongated target that extends downwardly from the belt, and a foot plate. The elongated target comprises a pad, preferably thick and wide enough to fully absorb the force of a trainee's kicks, and a metal plate to which the pad is attached. The foot plate extends integrally from the metal plate and is adapted to be stepped upon by the sparring partner while training. | 2013-08-29 |
20130224708 | Physical Training System and Method - Systems, methods, and computer-readable media for providing a physical training routine for a user are disclosed. One such method may include displaying a visual indicator indicating a movement to be completed by the user and determining whether the user completes the movement. The methods also include recording one or more characteristics of the movement and providing feedback to the user based on the one or more characteristics. | 2013-08-29 |
20130224709 | Portable Low Cost Computer Assisted Surgical Trainer and Assessment System - A system is provided for evaluating MIS procedures. The system includes a sensor configured to receive task-performance data, block components, and actuating components. The sensor, block components, and actuating components are configured to simulate a training task. The system also includes a processor. The processor is configured to determine, based on the received task-performance data, a trial task-performance metric corresponding to a trial performance of the training task. The processor is also configured to select a reference task-performance metric from a plurality of reference task-performance metrics. Each reference task-performance metric in the plurality corresponds to a respective reference performance of the training task. The processor is additionally configured to determine, based on a comparison of the trial task-performance metric to the reference task-performance metric, a task-performance classification level. The processor is further configured to cause a graphical display to provide an indication of the task-performance classification level. | 2013-08-29 |
20130224710 | ROBOTIC DEVICE FOR USE IN IMAGE-GUIDED ROBOT ASSISTED SURGICAL TRAINING - A robotic device for use in image-guided robot assisted surgical training, the robotic device comprising a manual interface structure configured to simulate handling of a surgical tool; a translational mechanism for translational motion of the manual interface structure; a rotational mechanism for rotational motion of the manual interface structure; and a spherical mechanism configured to decouple the orientation of the manual interface structure into spatial coordinates, wherein a linkage between the rotational mechanism, the rotational mechanism and the spherical mechanism, and the manual interface structure are disposed on opposing sides of an intersection of a pitch axis and a yaw axis of the spherical mechanism. | 2013-08-29 |
20130224711 | INFANT SIMULATOR - An infant simulator comprising a mannequin having a temperature sensor effective for sensing the environmental temperatures to which the mannequin is exposed, and a means effective for recording the sensed temperature. | 2013-08-29 |
20130224712 | MEDICAL TRAINING KITS AND METHODS TO SIMULATE TREATMENT OF UNCONTROLLED HEMORRHAGE - Medical training kits and methods include a simulated liquid blood which simulates mammalian whole blood and a simulated hemostatic component. The simulated liquid blood includes a gellable component, and a simulated hemostatic component includes a gelling agent. The gelling agent causes the gellable component in the simulated liquid blood to form a mass of semi-solid or solid material in response the simulated blood being brought into contact therewith to thereby simulate blood clotting. | 2013-08-29 |
20130224713 | ENHANCING KNOWLEDGE BASES USING RICH SOCIAL MEDIA - Methods and arrangements for developing knowledge bases from social media. A question is obtained from social media. Social media are consulted, and a legitimacy of the question is ascertained. All the answers to the question are harvested from the social media including the rich media that is associated with these answers, and the question is filtered out if determined not to be legitimate. | 2013-08-29 |
20130224714 | ENHANCING KNOWLEDGE BASES USING RICH SOCIAL MEDIA - Methods and arrangements for developing knowledge bases from social media. A question is obtained from social media. Social media are consulted, and a legitimacy of the question is ascertained. All the answers to the question are harvested from the social media including the rich media that is associated with these answers, and the question is filtered out if determined not to be legitimate. | 2013-08-29 |
20130224715 | SYSTEM AND METHOD FOR OPTIMIZING LEARNING BY CORRELATING STRUCTURED KNOWLEDGE AND LEARNING TECHNIQUES WITH PHYSICAL METAPHORS IN AN EDUCATIONAL COMPUTER GAME - A system and method for optimizing learning and retention of items learned over time maps bodies of knowledge to physical metaphors in an education computer game or simulation. Entire structured curricula or curriculum frameworks are mapped to isomorphic physical metaphor hierarchies. Recommended sequences through subject matter are mapped to sequences in the physical metaphor of the game or simulation. Various algorithms for computing the Ebbinghaus “spacing effect” for reviewing items about to be forgotten by a student to optimize retention of subject matter are mapped to physical metaphors in the game or simulation. The use of a “predator-prey” computer algorithm to find students' subject matter knowledge weak points is mapped to a physical metaphor. Similarly, devices to enhance the student's learning curve, such as to induce perseverance, or raise motivation via competition, or via praise from an authority figure, are mapped to physical metaphors in the game or simulation. | 2013-08-29 |
20130224716 | CLOUD-BASED MULTIMEDIA TEACHING SYSTEM, DEVELOPMENT METHOD AND INTERACTION METHOD THEREOF - The present invention discloses a cloud-based multimedia teaching system, a development method and an interaction method thereof. In the present invention, a teacher produces a course in the Abode Flash format and uploads it from a client computer to a multimedia teaching system via the cloud; the multimedia teaching system communicates with a back-end server via a server framework in the Flash Remoting technology and establishes the course in the back-end server; the user interface of the multimedia teaching system contains a plurality of buttons linked to the courses. When a user clicks on a button of the user interface to select a course, the multimedia teaching system retrieves related data of the course from the back-end server via the server framework in the Flash Remoting technology and presents the data on the user interface thereof. | 2013-08-29 |
20130224717 | COMPUTERIZED LEARNING METHODS AND SYSTEMS FOR USE IN GROUP-LEARNING SETTINGS - A computer-implemented method enables guides to distribute learning items to a plurality of participants in a group learning setting in a controlled manner and to guide the participants through learning activities associated with the learning items. The guides and participants operate network-connected computing devices. The method includes the steps of: (a) providing a structured collection of learning items arranged in a given order on a computing device operated by a guide, each learning item being associated with a learning activity to be performed on computing devices operated by the participants; and (b) electronically distributing learning items in the structured collection to computing devices operated by the participants successively in the given order based on instructions received from the guide. | 2013-08-29 |
20130224718 | METHODS AND SYSTEMS FOR PROVIDING INFORMATION CONTENT TO USERS - Methods and system for organizing and providing informational content to users are disclosed. According to an aspect, a method may be implemented by a processor and include receiving user response to presentation of informational content associated with a first difficulty level. The method may also include associating a second difficulty level with the informational content based at least partly on the user response and the first difficulty level. Further, the method may include providing the informational content to a user based at least partly on the second difficulty level. | 2013-08-29 |
20130224719 | DIGITAL ASSIGNMENT ADMINISTRATION - A digitally administered assignment includes a workspace for a student and an internal automated grading code hidden from and not accessible by the student, the internal automated grading code configured to execute on the student's local computing device and to evaluate work performed by the student in the workspace. A method for digital assignment administration includes making an assignment with internal automated grading criteria available to a student and evaluating the assignment using the internal automated grading criteria on the student's local computing device. | 2013-08-29 |
20130224720 | METHODS AND APPARATUS FOR DYNAMIC TRAINING AND FEEDBACK - Methods and apparatus for dynamic training and feedback according to various aspects of the present invention generally comprise administering training material to a user in conjunction with one or more icons associated with a skill the training material is intended to develop, tracking the progress of a user through the training material, and representing the tracked progress using the one or more icons. The training material may be administered in conjunction with an interactive feature to facilitate collaboration. | 2013-08-29 |
20130224721 | METHOD TO GRAPHICALLY DISPLAY A VEHICLE CONDITION - A method for graphically displaying a vehicle condition within an automotive vehicle is disclosed. The method includes the steps of receiving information from a sensor on a vehicle regarding a vehicle condition. The vehicle condition is measured against a predetermined level for that specified vehicle condition. The method then determines if the vehicle condition is above the predetermined level. If the vehicle condition is above the predetermined level, the method then transmits information regarding the vehicle condition to a processor connected to a display screen. The method then proceeds to graphically display the vehicle condition on a vehicle within the vehicle by means of a graphical replication of an image replication of the actual vehicle condition in the actual vehicle being used. | 2013-08-29 |
20130224722 | SYSTEM AND METHOD OF SELECTIVELY REMOVABLE WRITING TABLETS - A system for attaching at least one writing tablet to a surface configured to receive the writing tablet, including a backing element and a tablet element. The backing element and tablet elements each comprise at least one surface with an array of touch fastening elements allowing the backing element and tablet element to be removably engageable to one another. At least one surface of the tablet element may comprise a surface allowing a user to draw or write on the surface in a dry or wet erase manner. | 2013-08-29 |
20130224723 | DISPLAY BOARD ASSEMBLY - An erasable marker board assembly includes a metal backing panel, a pre-printed poster and a transparent panel. The pre-printed poster bears unchanging information, and defines areas for additional information to be written by hand with an erasable marker. A transparent panel overlies the poster and provides a top surface upon which the additional information may be written with an erasable marker. The transparent panel may comprise a panel of glass or a panel of transparent acrylic material. A plurality of releasable fasteners secure the metal backing panel, the pre-printed poster, and the transparent panel together. | 2013-08-29 |
20130224724 | CRITICAL POINT DRYING SYSTEMS AND METHODS FOR IN SITU TISSUE PRESERVATION - Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state. | 2013-08-29 |
20130224726 | METHOD AND APPARATUS FOR CALIBRATING A FLOW CYTOMETER - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 2013-08-29 |
20130224727 | SYSTEMS AND METHODS FOR SORTING PARTICLES - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 2013-08-29 |
20130224728 | METHOD FOR THE PRODUCTION OF 2-BUTANOL - A method for the production of 2-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product. | 2013-08-29 |
20130224729 | Biodetection Methods and Compositions - Diagnostic methods and compositions for detecting biological material are provided. | 2013-08-29 |
20130224730 | PEPTIDE LIGANDS - A method of solid phase selection of peptide ligands for target proteins is presented. 15-20mers or greater are addressed in a microarray, and the target protein and optional competitor bound thereto and binding compared. A specific signal for the target protein indicates that a peptide has strong affinity for the target. Ligands can be coupled to solid supports and used for affinity purification of the target proteins as well as detection and modulation of target proteins. Specific peptide ligands for immuno-purifying norovirus. | 2013-08-29 |
20130224731 | ACOUSTIC RADIATION FOR EJECTING AND MONITORING PATHOGENIC FLUIDS - The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used. | 2013-08-29 |
20130224732 | METHOD FOR AMPLIFYING VARIATION OF FREQUENCY OF SIGNAL IN PIEZOELECTRICAL BIOSENSOR - Provided is a method for amplifying a frequency variation of a detected signal in a biosensor that is used for detecting a biomolecule by measuring a change in frequency of an oscillating signal, the change being caused by pressure a biomolecule applies to a piezoelectric substance. The method for amplifying a frequency variation of a detected signal comprises the steps of: (a) applying a sample to a probe being fixed to an upper portion of a substrate of the biosensor to allow a biomolecule in the sample to be bound to the probe; (b) applying protein tagged with a metal particle to the biosensor to allow the protein and the biomolecule to be bound with each other; and (c) applying a metal enhancer to the biosensor to allow the metal enhancer to be bound to the metal particle having been bound to the protein. | 2013-08-29 |
20130224733 | METHOD AND APPARATUS FOR SORTING PARTICLES - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 2013-08-29 |
20130224735 | Fluorescent Chemical Compounds Having High Selectivity for Double Stranded DNA, and Methods for Their Use - Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA. | 2013-08-29 |
20130224736 | MICROFLUIDIC DEVICE AND METHOD FOR PROCESSING OF MACROMOLECULES - A microfluidic device and method for enzymatic processing of ultra-long macromolecules is accomplished using a microfluidic device a reaction chamber with a first manifold, a second manifold, and a plurality of reaction channels. Each reaction channel extends from the first manifold to the second manifold. First inlet and outlet channels fill the reaction channels via the manifolds with one or more macromolecule containers suspended in a first carrier fluid. The first inlet and outlet channels are configured such that a flow is guided through the reaction channels, and an enzymatic reagent is fed to the reaction chamber essentially without displacing the macromolecule containers trapped in the reaction channels. The second set of inlets and outlets are configured such that a flow established from the second inlet to the second outlet is guided through at least one of the manifolds and bypasses the reaction channels. | 2013-08-29 |
20130224737 | Method For Determining The Production Of Reactive Oxygen Species In A Cellular Population - The invention relates to a method for determining the production of reactive oxygen species in a cellular population. The invention also relates to a method for determining the need for an antioxidant treatment of a male subject, and to a method for identifying a substance that can reduce the reactive oxygen species in a cellular population. | 2013-08-29 |
20130224738 | DETECTING DNA METHYLATION OF BCL2, CDKN2A AND NID2 GENES TO PREDICT BLADDER CANCER IN HUMANS - The present invention provides a method of detecting DNA methylation of a plurality of genes consisting of CDKN2A, BCL2 and NID2 in a urine sample from a human. Methods and compositions are provided herein for detecting and diagnosing bladder cancer by obtaining a urine sample from a human subject suspected of bladder cancer, followed by detecting DNA methylation of CDKN2A, BCL2 AND NID2 in urine samples from the individual. The present method permits specific detection of DNA methylation of the selected gene promoters in urine as a biomarker for bladder cancer in humans. | 2013-08-29 |
20130224739 | GENETIC MARKERS FOR RISK MANAGEMENT OF VASCULAR DISEASE - Certain genetic markers have been found to be useful for risk management of vascular conditions, including abdominal aortic aneurysm, myocardial infarction, peripheral arterial disease and venous thromboembolism. The invention provides diagnostic applications using such markers, including methods of determining a susceptibility of vascular conditions. | 2013-08-29 |
20130224740 | ANALYTICAL METHODS FOR CELL FREE NUCLEIC ACIDS AND APPLICATIONS - The present invention is directed to an in vitro method of detecting cell free nucleic acids, preferably cell free DNA (cfDNA) in a body fluid sample from an individual or a patient, wherein the method comprises the step of accurately and sensitively determining the concentration of cell free nucleic acid in the sample and/or determining the concentration or amount of said cell free nucleic acid of a size range and/or the index of integrity or size fraction ratio (SFR) of said cell free nucleic acid and/or the determination of the presence of genetic polymorphisms (such as known Single Nucleotide Polymorphisms (SNPs) or mutations). The invention encompasses also a method to discriminate body fluid individuals where cfDNA are highly released by comparing the size profile obtained for at least one of three size ranges of cfDNA. The invention also encompasses a method for analysing cell nucleic acids in individuals for the diagnosis, prognosis or for assessing the evolution of a physiological state, such as the progression of a tumor or metastatic cancer, for monitoring the efficacy of a cancer treatment in a patient or for theragnostic purposes implementing the analysis of these biomarkers. | 2013-08-29 |
20130224741 | Molecular Method for the Identification of Mating Type Genes of Truffles Species - The invention concerns a method for determining the | 2013-08-29 |
20130224742 | METHOD FOR DETECTING AND/OR QUANTIFYING HUMAN DNA - The present invention relates to a method, kit and use of various nucleic acid sequences for deleting and/or quantifying one or more nucleic acids of a genome in a sample. Wherein the nucleic acid is amplified and the locus that is amplified is a multi copy locus within the genome, the multicopy locus has copies on at least two different chromosomes and the amplification product is detected and/or quantified. | 2013-08-29 |
20130224743 | Method for accurately counting starting molecules - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 2013-08-29 |
20130224744 | INTEGRATED DEVICE FOR REAL TIME QUANTITATIVE PCR - A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method. | 2013-08-29 |
20130224745 | COMPOSITIONS AND METHODS FOR DETECTION OF PROPIONIBACTERIUM ACNES NUCLEIC ACID - Methods for amplifying and detecting | 2013-08-29 |
20130224746 | DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS - The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference. | 2013-08-29 |
20130224747 | Pathogenecity Islands of Pseudomonas Aeruginosa - Disclosed are | 2013-08-29 |
20130224748 | METHODS AND COMPOSITIONS FOR DETECTING ENDOMETRIAL OR OVARIAN CANCER - Some embodiments of the present invention relate to methods and compositions for assessing the absence, presence, progression, or stage of cancer. In particular, methods and compositions for detecting endometrial cancer or ovarian cancer are provided. | 2013-08-29 |
20130224749 | COMPOSITION AND METHOD FOR SEQUENCING NUCLEIC ACID - A composition for sequencing DNA is provided and comprises a nuclease and a nuclease-resistant sequencing primer. A method of preparing DNA for sequencing and a method of sequencing DNA are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the nuclease-resistant sequencing primer is essentially non-degraded. | 2013-08-29 |
20130224750 | METHODS AND SYSTEMS FOR DNA ISOLATION ON A MICROFLUIDIC DEVICE - The present invention relates to methods and systems for the isolation of DNA on a microfluidic device and the subsequent analysis of the DNA on the microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for the isolation of DNA from patient samples on a microfluidic device and use of the DNA for performing amplification reactions, such as PCR, and detection, such as thermal melt analysis, on the microfluidic | 2013-08-29 |
20130224751 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 2013-08-29 |
20130224752 | METHOD FOR EARLY DETERMINATION OF RECURRENCE AFTER THERAPY FOR PROSTATE CANCER - This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have early stage biochemical reoccurrence (ES-BCR) or stable disease. | 2013-08-29 |
20130224753 | GENETIC TESTING METHOD AND TESTING APPARATUS - A genetic testing method and an apparatus therefor are provided, in which temperatures of a plurality of reaction tubes are independently controlled using a thermostat, a temperature detecting device, and a heating and cooling device provided on each of the reaction tubes, the reaction tubes each accommodate an amplification liquid and a component necessary for amplification, temperature is controlled at individual positions to hold the reaction tubes and at a predetermined temperature set at the individual positions according to an analysis and testing protocol predetermined at individual positions of the reaction tubes, a controlled temperature value is monitored in a reaction tube unit and a corrected value of controlled temperature is computed and stored on a reaction tube unit, a temperature of the reaction tube is controlled based on the computed value, and light emission of the amplification liquid accommodated in the reaction tube is measured. | 2013-08-29 |
20130224754 | METHOD FOR THE SELECTION OF COMPOUNDS USEFUL FOR THE TREATMENT OF PSYCHIATRIC AND NEURODEGENERATIVE DISEASES - The present invention concerns a method for the identification of specific compounds which modulate brain-derived neurotrophic factor, which can be used as drugs for the treatment of neurological and neuropsychiatric diseases and which are suitable for the treatment of deleterious effects caused to the nervous system by abuse of illegal or legal drugs. | 2013-08-29 |
20130224755 | METHOD FOR DETECTING DNA ADDUCTS IN SALIVA - A method of detecting DNA adducts in saliva is disclosed herein. The method comprises the following steps: providing a salivary DNA; adding at least one isotope-labeled internal standard and a plurality of enzymes into the salivary DNA to hydrolyze the salivary DNA into a plurality of nucleosides; extracting the plurality of nucleosides by using a solid-phase extraction column; and detecting and quantifying at least one DNA adduct in the plurality of extracted nucleosides by utilizing a stable isotope dilution nano-flow liquid chromatography-nanospray ionization tandem mass spectrometry (LC-NSI/MS/MS). | 2013-08-29 |
20130224756 | OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL - The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell. | 2013-08-29 |
20130224757 | INDUCED SPORULATION SCREENING METHOD - The present invention relates to a method of screening for an improved enzyme variant, said method comprising the steps of: (i) providing a recombinant host cell capable of sporulating comprising a polynucleotide encoding a sporulation factor and a polynucleotide encoding an enzyme variant which are operably linked to an inducible promoter; (ii) culturing the host cell under conditions suitable to induce the formation of spores; (iii) culturing the spores obtained in step (ii) in a medium containing a substrate for the enzyme variant; and (iv) determining the activity of the enzyme variant. | 2013-08-29 |
20130224758 | USE OF SIGNAL ENHANCING COMPOUNDS IN ELECTROCHEMILUMINESCENCE DETECTION - The application provides methods for the detection of an analyte in a sample by electrochemiluminescence using certain reagent compositions. Reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the reagent compositions are disclosed. In particular, the application relates to the use of novel combinations of compounds, which can be used in said measurements to provide improved ECL assay performance. | 2013-08-29 |
20130224759 | METHODS, DEVICES, KITS AND COMPOSITIONS FOR DETECTING ROUNDWORM - Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a mammalian sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated. | 2013-08-29 |
20130224760 | Zinc-Responsive Peptides, and Methods of Use Thereof - Described herein are compounds and methods useful in the detection of, e.g., Zn | 2013-08-29 |
20130224761 | NON COVALENT MOLECULAR STRUCTURE, COMPRISING A PORPHYRIN BASED GLYCOCONJUGATE, DEVICE COMPRISING THE SAME AND ITS USE FOR DETECTION OF LECTIN - The present invention relates to a non covalent molecular structure comprising a carbon nanostructure and a porphyrin based glycoconjugate (I) which is linked to the said carbon nanostructure by a non covalent link, the said glycoconjugate (I) having the formula (I): wherein M is a metal selected in the group comprising Fe, Ni, Zn, Cu, Mn, Cr or Co, B is a group which is present on at least one of the four phenyl group (C | 2013-08-29 |
20130224762 | MAGNETIC CELL DETECTION - Specific labeling of cells enables magnetic cell detection. The cell type to be detected is labeled, magnetic labels being bound to epitopes of a first cell-specific epitope type via antibodies of a first antibody type. Additionally, second/further magnetic labels are bound to epitopes of a second cell-specific epitope type on the cells via antibodies of a second antibody type, or the magnetic labels are bound to the antibodies of the first antibody type via antibodies of another antibody type and the antibodies of the first antibody type are bound to the epitopes of the first cell-specific epitope type on the cells. | 2013-08-29 |
20130224763 | BIOLOGICAL MOLECULE DETECTING APPARATUS AND BIOLOGICAL MOLECULE DETECTING METHOD - A biological molecule detecting apparatus capable of highly sensitive measurements is provided. A laser was emitted onto a solution, to impart external force onto free molecules and binding molecules within the solution. The external force inhibited Brownian motion of the free molecules and the binding molecules. The concentration of a detection target substance which is associated the binding molecules can be measured with high sensitivity, by measuring the Brownian motion of the free molecules and the binding molecules within the solution irradiated with the laser. | 2013-08-29 |
20130224764 | BIOLOGICAL MOLECULE DETECTING APPARATUS AND BIOLOGICAL MOLECULE DETECTING METHOD - A biological molecule detecting apparatus capable of highly sensitive measurements is provided. The emission direction of an orientation controlling light beam was periodically switched, to periodically switch the orientation direction of binding molecules | 2013-08-29 |
20130224765 | NANO-POROUS MEMBRANE BASED SENSORS - Sensors include nano-porous alumina membranes that are sensitized by immobilization of antibodies in the nano-pores. The nano-membranes can be sensitized to respond to a single target compound, or different portions of the nano-membrane can be differently sensitized. Capture of the target compound can be detected based on a spectral signature associated with electrical conductance in the nano-pores. | 2013-08-29 |
20130224766 | VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) PROTEIN AND GENE, MUTANTS THEREOF, AND USES THEREOF - Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors: polynucleotides encoding the polypeptides: vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides. Methods of inhibiting endothelial cell proliferation are also provided. | 2013-08-29 |
20130224767 | IMMUNOCHROMATOGRAPHIC ASSAY METHOD AND APPARATUS - In an immunochromatographic assay method for performing an assay related to a specimen by reacting a reagent held by a carrier and the specimen with each other, and by obtaining an image signal by imaging a reagent portion by a camera, and by measuring, based on the image signal, the color-developed state of the reagent, a morphological opening-operation is applied to the image signal by using a structuring element the size of which is less than or equal to a signal-change-width of the reagent portion that has developed color, and a morphological opening-operation is applied to the image signal by using a structuring element the size of which is larger than the signal-change-width of the reagent portion that has developed color. The color-developed state is measured based on a difference signal obtained by performing a subtraction between the image signals to which the opening-operations have been applied respectively. | 2013-08-29 |
20130224768 | IMMUNOCHROMATOGRAPHIC ASSAY METHOD AND APPARATUS - In an immunochromatographic assay method for assaying a specimen by reacting a reagent held by a carrier and the specimen with each other, and by obtaining an image signal by imaging a reagent portion that has been reacted, and by measuring, based on the image signal, the color-developed state of the reagent caused by the reaction, the carrier holds reagents in such a manner that they do not extend continuously for the full length of the carrier in any one of two-dimensional directions along the surface of the carrier. A morphological opening operation is applied to the image signal, with respect to each of the two-dimensional directions, by using a structuring element the size of which is less than or equal to a signal change width of the reagent portion that has developed color, and the color-developed state is measured based on the image signal after the opening operation. | 2013-08-29 |
20130224769 | METHODS OF USING CHEMOKINE PANEC-1 ANTIBODIES - The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2-encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein. | 2013-08-29 |
20130224770 | Antibody Diluent Buffer - The compositions described include an antibody diluent buffer that minimizes the amount of antibody required for immunoassays and further improves the performance of antibody-based assays. The claimed antibody diluent buffer comprises a high-molecular weight neutral polymer and an antibody that specifically binds to an antigen of interest, wherein the antibody remains in solution in the presence of the polymer. Methods for the use of the antibody diluent buffer to detect an antigen, even trace amounts of an antigen, in an antibody-based assay are also disclosed herein. | 2013-08-29 |
20130224771 | ANTI-MULLERIAN HORMONE DETECTION IN WHOLE BLOOD - The present invention provides methods, kits, compositions, and devices for detecting Anti-Mullerian hormone (AMH) in whole blood samples. In certain embodiments, the methods, kits, compositions, and devices employ immunoassays that generate a colorimetric or fluorescent signal (e.g., using antibodies conjugated to gold nanoparticles or fluorescent particles) where the signal generated is proportional to the approximate concentration of AMH in a whole blood sample. In particular embodiments, the present invention provides quantitative or semi-quantitative lateral flow immunoassay devices and kits for detecting AMH at home (e.g., in order for women to estimate their ovarian age or diagnose polycystic ovarian syndrome). | 2013-08-29 |
20130224772 | METHOD FOR DETECTING ANTI-HE4 ANTIBODIES AND METHODS OF DIAGNOSIS AND/OR PROGNOSIS OF CONDITIONS ASSOCIATED WITH HE4-EXPRESSING CELLS - The present invention features, inter alia, compositions and methods related to the detection of HE4-expressing tumor cells in a subject. The methods include detection of anti-HE4 antibodies in a biological sample obtained from the subject. The methods are useful for diagnosis and monitoring the efficacy of treatments for cancers in which HE4 is expressed, for example, ovarian cancer. | 2013-08-29 |
20130224773 | Method for Rapid Growth, Detection and Identification of Live Microorganisms Immobilized on Permeable Membranes by Antibodies - A method is provided for rapid growth, detection and identification of one or more live target microorganisms grown on a nutrient-rich medium. Grown microcolonies of the one or more live microorganisms attach to permeable membrane having immobilized antibodies thereon specific for the one or more live target microorganisms. The permeable membrane is contacted with at least one type of antibody-enzyme conjugate specific to antigens of the one or more live target microorganisms. Non-specific cells are washed from the permeable membrane and the membrane is stained to allow coloration and subsequent identification of the one or more live targeted microorganisms. The entire method allows for the rapid growth, detection and identification of live microorganisms in about 5 hours or less. | 2013-08-29 |
20130224774 | METHODS AND MATERIALS FOR AMPLIFICATION OF A SIGNAL IN AN IMMUNOASSAY - Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the signal amplifying molecule within its matrix and may also have antibodies affixed to its surface for molecular recognition. Ultrafine particles are also provided having a matrix component that includes a signal amplifying molecule and at least one antibody specific for the antigen or biomaterial. The ultrafine particles of the present disclosure may be used in assays for the detection, including quantification, of one or more antigens present in a biological sample. | 2013-08-29 |
20130224775 | Apparatus and Methods for Analyte Measurement Immunoassay - The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments. | 2013-08-29 |
20130224776 | PCan065 Antibody Compositions and Methods of Use - The invention provides isolated anti-PCan065 antibodies that bind to PCan065. The invention also encompasses compositions comprising an anti-PCan065 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PCan065 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PCan065 antibodies. The invention encompasses a method of producing the anti-PCan065 antibodies. Other aspects of the invention are a method of killing an PCan065-expressing cancer cell, comprising contacting the cancer cell with an anti-PCan065 antibody and a method of alleviating or treating an PCan065-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PCan065 antibody to the mammal. | 2013-08-29 |
20130224777 | Screening method for finding samples having antiphospholipid antibodies - The present invention is in the field of coagulation diagnostics and relates to a screening process for finding samples containing antiphospholipid antibodies (lupus anticoagulants), wherein the platelet aggregation-stimulating action of said antiphospholipid antibodies is determined in vitro. | 2013-08-29 |
20130224778 | Methods for Determination of Ethanol Consumption - The present invention discloses a method for assessment of previous ethanol exposure comprising the steps of: (i) obtaining a sample from the body of a subject; (ii) quantitatively determining the level of one or several bio-precursors of PEth (Formula I) and the level of the corresponding one or several PEth-homologues (Formula II) in the sample; and (iii) obtaining a ratio between the level of one or several bio-precursors of PEth and the level of the corresponding one or several PEth-homologues; wherein the subject is a human or animal. Additional related methods are also disclosed. | 2013-08-29 |
20130224779 | METHOD FOR LARGE SCALE PREPARATION OF THE ACTIVE DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE WITHOUT FUSION PROTEIN - The present invention relates to methods for identifying inhibitors or activators of protein tyrosine phosphatase (PTP). In some examples, the methods utilize a PTP active domain with high activity and stability expressed without help of a fusion protein, by using computer based protein structure prediction technique. PTP prepared by the disclosed method may also be used as an antigen protein for the construction of a selective antibody and as a protein for the studies of PTP structure and functions. | 2013-08-29 |
20130224780 | LIQUID CRYSTAL DEVICE FOR SCREENING CLEANERS OF BIOFOULING OR FOR VALIDATING CLEANING PROCESSES - Methods and devices for assaying the effectiveness of a cleaning composition in removing a protein or a biofilm from a surface are disclosed. Such methods include the steps of providing one or more proteins at an interface between an aqueous phase and a liquid crystal phase or at the surface of a liquid crystal, contacting the interface or liquid crystal surface with a cleaning composition, and observing the orientational ordering of the liquid crystal at the interface or liquid crystal surface. A continuous change in the orientational ordering of the liquid crystal at the interface or liquid crystal surface indicates that the proteins are being removed from the interface, and the rate of change in orientational ordering, the extent of the change in orientational ordering, or both, are correlated with the effectiveness of the cleaning composition. Because the ability of cleaning agents to remove proteins from the interface or liquid crystal surface is correlated with the state and concentration of the protein that is being removed, similar methods and devices can be used to assay the effectiveness of a putative protein stabilizing agent or to assay the optimal concentration of a protein for preventing the unfolding of the protein. | 2013-08-29 |
20130224781 | DIAGNOSTIC APPARATUS AND DIAGNOSTIC METHOD USING THE SAME - Provided is a diagnostic apparatus. The diagnostic apparatus includes a microfluidic chip including first and second measurement parts for respectively measuring an amount of hemoglobin and an active degree of an enzyme within a blood sample. The second measurement part of the microfluidic chip analyzes the active degree of the enzyme within the blood sample using voltammetry. | 2013-08-29 |
20130224782 | NEUROGENESIS SCREENING METHOD AND SYSTEM USING ADIPOSE TISSUE DERIVED STEM CELLS - Provided herein are methods for identifying a neurogenesis-modulating compound, comprising: culturing adipose-derived stem cells (ADSCs) in the presence of a candidate compound; and determining the extent of neurogenesis in the ADSCs and systems for identifying a neurogenesis modulating compound. Also provided are methods of promoting neurogenesis in ADSCs. | 2013-08-29 |
20130224783 | METHOD FOR DETECTION OF LIPOSOLUBLE VITAMINS - The invention relates to a method for analysis of liposoluble vitamins of biological materials. It is proposed to perform reagent storage, sample application and conducting of the measuring in one reaction vessel and to correct interfering ingredients during the photometric evaluation. | 2013-08-29 |
20130224784 | METHOD FOR ASSESSING THE EFFICACY OF A TR1 CELL THERAPY IN A SUBJECT - A method for assessing whether a patient subjected to an antigen-specific Tr1 cell therapy is responding to the treatment, includes: determining in vitro the antigen-specific proliferation of T cells contained in a cell sample from the patient; and comparing the antigen-specific proliferation to a standard reference, thereby determining whether the patient is responding or not to the treatment. | 2013-08-29 |
20130224785 | METHOD AND DEVICE FOR DESORPTION IONIZATION - The invention relates to method and apparatus for production of gaseous ions from components of a condensed phase sample and analysis thereof, wherein one or more liquid jet(s) is/are directed to the surface of the sample to be investigated, where the impact of the liquid jet on the sample surface produces droplets carrying sample particles which are turned into gaseous ions via the evaporation of liquid or, if desired, by a subsequent ionization after the evaporation and the obtained sample particles are analyzed by a known method. | 2013-08-29 |
20130224786 | FLOW CYTOMETER APPARATUS AND METHOD - A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation. The flow cytometry units share an integrated platform comprising at least one of the following: (1) a common supply of particles; (2) a common housing; (3) a common processor for controlling operation of the units; (4) a common processor for receiving and processing information from the units; and (5) a common fluid delivery system. The integrated platform can include a common source of electromagnetic radiation. A method of the invention comprises using a plurality of flow cytometry units sharing the integrated platform to perform a flow kilometric operation, such as analyzing or sorting particles. | 2013-08-29 |