35th week of 2014 patent applcation highlights part 59 |
Patent application number | Title | Published |
20140243503 | FGF21 MUTANTS AND USES THEREOF - The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions. | 2014-08-28 |
20140243504 | ANTIBODIES COMPRISING CHIMERIC CONSTANT DOMAINS - Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided. | 2014-08-28 |
20140243505 | BISPECIFIC ANTIBODY - Provided are bispecific antibodies comprised of a single-chain unit having specificity to an immune cell and a monovalent unit having specificity to a tumor cell or a microorganism. The single-chain unit includes a single-chain variable fragment (scFv) fused to an Fc fragment and the monovalent unit includes a light chain and heavy chain pair. Also provided are methods of preparing bispecific antibodies and pharmaceutical and diagnostic uses of these antibodies. | 2014-08-28 |
20140243506 | ANTAGONISTS OF IL17C FOR THE TREATMENT OF INFLAMMATORY DISORDERS - The present invention provides antagonists of IL17C for use in the treatment of an inflammatory disorder. | 2014-08-28 |
20140243507 | METHOD OF SCREENING ANTIBODIES WITH HIGH ANTIGEN SELECTIVITY - Provided is a method of screening a target-specific antibody for an antigen that undergoes structural change in a particular physiological condition. | 2014-08-28 |
20140243508 | METHOD FOR THE PURIFICATION OF ANTIBODIES - A method for the purification of immunoglobulins by ion exchange chromatography is described. The chromatographic method uses a weak ion exchange resin and a single step elution process for the purification of an immunoglobulin. Additionally a method for the determination of the salt concentration for the single step elution of an immunoglobulin from an ion exchange resin is described. | 2014-08-28 |
20140243509 | NEAR INFRARED FLUOROGEN AND FLUORESCENT ACTIVATING PROTEINS FOR IN VIVO IMAGING AND LIVE-CELL BIOSENSING - Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags. An “optical window,” farther red than most autofluorescence sources and in a region of low hemoglobin and water absorbance, lies between 650 and 900 nm. This valley of relative optical clarity is an attractive target for fluorescence-based studies within tissues, intact organs, and living organisms. Novel fluorescent tags were developed herein, based upon a genetically targeted fluorogen activating protein and cognate fluorogenic dye that yields emission with a peak at 733 nm exclusively when complexed as a “fluoromodule”. This tool improves substantially over previously described far-red/NIR fluorescent proteins in terms of brightness, wavelength, and flexibility by leveraging the flexibility of synthetic chemistry to produce novel chromophores. | 2014-08-28 |
20140243510 | METHODS FOR PURIFYING ERYTHROPOIETIN ANALOGS HAVING LOWER ISOELECTRIC POINT - The present invention relates to a method for purifying an erythropoietin analog having a low isoelectric point below 4 by adding an N-linked sugar chain with high purity. In accordance with the present invention, the erythropoietin analog having an isoelectric point below 4, which is an isoform having more sialic acid residues, can be effectively purified via three-step chromatographic processes in short time at lower cost. | 2014-08-28 |
20140243511 | Functionalized lignin and method of producing the same - In this study, commercially available softwood lignin was esterified with tall oil fatty acid (TOFA) and tested as barrier material in fiber-based packaging material. The modified lignin samples were applied with a bar coater forming an even coating on the paperboard substrate. A significant decrease in WVTR and OTR value was observed for paperboard coated with the modified lignin as well as pure TOFA used as a reference. In contrast to the TOFA coating, the modified lignin coatings exhibited a high and stable contact angle. The coating material did not affect the tensile strength of the paperboard. According to the results, the demonstration of the conversion of lignin into a value added product has been shown. Furthermore, the novel coating material shows promising properties for the development as sustainable barrier material in fiber-based packaging material to replace oil-placed barriers. | 2014-08-28 |
20140243512 | SORBENT COMPRISING AN AROMATIC RING SYSTEM ON ITS SURFACE FOR THE PURIFICATION OF ORGANIC MOLECULES - In a first embodiment the present invention relates to a sorbent comprising a porous inorganic solid support material having on its surface a film of a crosslinked polyvinylamine comprising derivatized amine groups and amine groups binding to the surface of the support material via electron donor/acceptor interactions. In a second embodiment the present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbents according to the invention for the purification of organic molecules, in particular pharmaceutical active compounds, preferably in chromatographic applications. | 2014-08-28 |
20140243513 | Methods for the Production of 3-O-Deactivated-4'-Monophosphoryl Lipid A (3D-MLA) - Herein is disclosed a method for producing lipopolysaccharide (LPS), comprising: (a) growing a culture of a deep rough mutant bacterial strain in a medium; (b) maintaining the culture in stationary phase for at least about 5 hr; (c) harvesting, cells from the culture; and (d) extracting LPS from the cells. The method allows for the production of an LPS which can be used to produce a 3-O-deacylated monophosphoryl lipid A (3D-MLA) having at least about 20 mol % of the hexaacyl congener group. | 2014-08-28 |
20140243514 | METHOD FOR THE ENRICHMENT OF REBAUDIOSIDE B AND/OR REBAUDIOSIDE D IN STEVIA-DERIVED GLYCOSIDE COMPOSITIONS USING ADSORB-DESORB CHROMATOGRAPHY WITH A MACROPOROUS NEUTRAL ADSORBENT RESIN - The invention relates to the use of adsorb/desorb chromatography to prepare enriched compositions comprising rebaudioside B and/or rebaudioside D. Compositions with enriched rebaudioside-B and/or rebaudioside-D components may be prepared from Stevia-derived glycoside compositions using an adsorb-desorb chromatography process where the stationary phase of the chromatography bed comprises a macroporous neutral adsorbent resin. | 2014-08-28 |
20140243515 | ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF - An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202. | 2014-08-28 |
20140243516 | ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF - An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202. | 2014-08-28 |
20140243517 | METHODS OF PRODUCING C-ARYL GLUCOSIDE SGLT2 INHIBITORS - Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents. | 2014-08-28 |
20140243518 | Method for Preparing Cationic Galactomannans - The present invention relates to a method for preparing cationic galactomannans, comprising the following steps:
| 2014-08-28 |
20140243519 | METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS - The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applica | 2014-08-28 |
20140243520 | PYRROLOPYRIDINES AS KINASE INHIBITORS - Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 2014-08-28 |
20140243521 | SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES - A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-I1, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q. | 2014-08-28 |
20140243522 | Herbicidal Benzoxazinones - The present invention relates to benzoxazinones of the general formula (I) | 2014-08-28 |
20140243523 | HUMAN EPITHELIAL CELL LINE FOR 3-D MODELIZING OF CANCER AND TREATMENT THEREOF - A cellular model is described that targets dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular model to screen for pharmacological compounds that can treat or prevent skin cancer, in particular, Basal Cell Carcinoma (BCC) lesions. | 2014-08-28 |
20140243524 | ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN - The compounds of the present invention are represented by the chemical structure found in Formula (I): | 2014-08-28 |
20140243525 | IMIDAZOLOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASE - Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases. | 2014-08-28 |
20140243526 | SELECTIVE HYDROGENATION OF ALDEHYDE WITH RU/BIDENTATE LIGANDS COMPLEXES - The present invention relates to processes for the reduction by hydrogenation, using molecular H | 2014-08-28 |
20140243527 | PURIFICATION METHODS FOR BETULONIC ACID AND BOC-LYSINATED BETULONIC ACID, AND ORGANIC SYNTHESIS OF BETULONIC ACID AMIDES WITH PIPERAZINE DERIVATIVES - The present invention provides a method of purifying betulonic acid contained the reaction product of organic synthesis of a Jones oxidation reagent and betulin extracted from the bark of a birch, a method of preparing a piperazine betulonic acid amide derivative, which is used as a chemical having an antibacterial function, using the high-purity betulonic acid obtained by the purification method and a derivative prepared by this method, a method of purifying a Boc-lysinated betulonic acid monomer ester contained in the reaction product of organic synthesis of lysine and the high-purity betulonic acid (starting material) obtained by the purification method, and a method of purifying Boc-lysinated betulonic acid contained in the reaction product of hydrolysis of the high-purity Boc-lysinated betulonic acid monomer ester. | 2014-08-28 |
20140243528 | Rosuvastatin Enantiomer Compounds - The invention discloses a method for the treatment of diseases, particularly those diseases characterized by diminished or aberrant cellular function, including AIDS, cancer, and Alzheimer's Disease. The method comprises administering a therapeutically effective amount of rosuvastatin enantiomer compounds in their (3R, 5R), (3S, 5R), or (3S, 5S) configurations, or pharmaceutically acceptable salts thereof Biologically-active rosuvastatin enantiomer compounds with (3R, 5R), (3S, 5R), and (3S, 5S) stereochemistry are also disclosed. | 2014-08-28 |
20140243529 | PROCESS FOR THE PREPARATION OF LURASIDONE HYDROCHLORIDE - Disclosed is a new and efficient process for the synthesis with high yields and purity of lurasidone hydrochloride, a medicament which is useful as a psychotropic substance. The process involves the preparation of lurasidone base in a reaction system not containing inorganic salts, followed by conversion of the latter to an addition salt with an organic carboxylic acid, which is finally converted to lurasidone hydrochloride. | 2014-08-28 |
20140243530 | Catalysis of Diketopiperazine Synthesis - Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ε-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide. | 2014-08-28 |
20140243531 | SUPERSTRUCTURES OF DIKETOPYRROLOPYRROLE DONORS AND PERYLENEDIIMIDE ACCEPTORS FORMED BY HYDROGEN-BONDING AND PI...PI STACKING - A quantitative model that describes the assembly of diketopyrrolopyrrole-based donors and a perylenediimide acceptor into chiral superstructures, as a result of both hydrogen bonding and π•••π stacking. This model provides thermodynamic parameters (ΔH° and ΔS°) for all noncovalent interactions involved in the assembly and explains the subtle supramolecular cues that convert disordered aggregates into well-defined helical assemblies. | 2014-08-28 |
20140243532 | NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES - This invention relates to novel precursors suitable for | 2014-08-28 |
20140243533 | METHOD FOR PRODUCTION OF F-18 LABELED A-BETA LIGANDS - This invention relates to improved methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives. | 2014-08-28 |
20140243534 | HALOGENATED COMPOUNDS FOR PHOTODYNAMIC THERAPY - Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications. | 2014-08-28 |
20140243535 | CRYSTALLINE GLYCOPYRROLATE TOSYLATE - Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed. | 2014-08-28 |
20140243536 | SEROTONIN REUPTAKE INHIBITORS - In one aspect, the invention relates to compounds of formula I: | 2014-08-28 |
20140243537 | PROCESS FOR THE PREPARATION OF OSELTAMIVIR AND METHYL 3-EPI-SHIKIMATE - The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (−)-methyl 3-epi-shikimate. | 2014-08-28 |
20140243538 | PRETREATED EPOXIDATION CATALYST AND A PROCESS FOR PRODUCING AN OLEFIN THEREWITH - A pretreated titanium silicalite with MFI structure (TS-1) catalyst which has been pretreated with methanol, and then optionally filtered and optionally air-dried to form a pretreated activated TS-1 catalyst. The activated TS-1 may be used in an epoxidation reaction with no additional methanol added and has equivalent activity to TS-1 used with large excesses of methanol. By removing the need for additional methanol during the reaction, the losses of epichlorohydrin from solvolysis are minimized significantly. | 2014-08-28 |
20140243539 | Process for the Production of Estetrol - The present invention relates to a process for the preparation of a compound of formula (I), hydrates or solvates thereof. | 2014-08-28 |
20140243540 | ALGAE EXTRACTION PROCESS - A method of extracting oil from algae by drying algae paste to a predetermined moisture content, contacting the algae paste with a polar solvent to make an algae-solvent solution and extracting oils from the algae paste into a solvent-oil solution, and separating extracted algae from the solvent-oil solution. An oil of whole and unhydrolyzed phospholipids, whole and unhydrolyzed glycolipids, lysolipids, and carotenoids extracted by the above method. An omega-3 fatty acid of docosahexanoic acids (DNAs) and eicosapentaenoic acids (EPAs) extracted from the above method. Isolated nutraceutical grade and pharmaceutical grade oil derived from algae and being free of toxins extracted by the above method. Isolated oil derived from algae including at least one omega-3 fatty acid of DHA and EPA at least partially in the form of whole and unhydrolyzed phospholipids and whole and unhydrolyzed glycolipids extracted by the above method. | 2014-08-28 |
20140243541 | USE OF RENEWABLE OIL IN HYDROTREATMENT PROCESS - The use of bio oil from at least one renewable source in a hydrotreatment process, in which process hydrocarbons are formed from said glyceride oil in a catalytic reaction, and the iron content of said bio oil is less than 1 w-ppm calculated as elemental iron. A bio oil intermediate including bio oil from at least one renewable source and the iron content of said bio oil is less than 1 w-ppm calculated as elemental iron. | 2014-08-28 |
20140243542 | OLEFIN METATHESIS CATALYST CONTAINING TUNGSTEN FLUORINE BONDS - A catalyst for the metathesis of olefins in general and specifically for the production of propylene from ethylene and butylene has been developed. The catalyst comprises a tungsten metal compound, which contains at least one tungsten-fluoro bond, dispersed or grafted onto a support. A specific example of the catalyst is the compound WOF(CH | 2014-08-28 |
20140243543 | IRON(II) CATALYSTS CONTAINING DIIMINO-DIPHOSPHINE TETRADENTATE LIGANDS AND THEIR SYNTHESIS - New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts. | 2014-08-28 |
20140243544 | METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS - Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided. | 2014-08-28 |
20140243545 | Methods for providing bond activation catalysts and related catalysts, systems, and methods - Described herein are catalysts for activation of an R—H bond in a R—H substrate and related catalytic matrices, compositions, methods and systems. | 2014-08-28 |
20140243546 | Processes - The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, | 2014-08-28 |
20140243547 | LINEAR (PER) FLUOROPOLYETHERS WITH -CF(CF3)COF END GROUPS AND DERIVATIVES THEREOF - The present invention relates to mono- or bi-functional (per)fluoropolyethers comprising a linear (per)fluoropolyether chain having two ends, wherein one or two ends contain —CF(CF | 2014-08-28 |
20140243548 | PREPARATION METHOD OF 1-PALMITOYL-3-ACETYLGLYCEROL, AND PREPARATION METHOD OF 1-PALMITOYL-2-LINOLEOYL-3-ACETYLGLYCEROL USING SAME - Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in high purity and high yield without a purification process using a column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in high purity and high yield using the same as a key intermediate. The method for preparing 1-palmitoyl-3-acetyl glycerol comprises the steps of: forming a reaction mixture including 1-palmitoyl-3-acetyl glycerol of the Formula 1 in the specification by reacting 1-palmitoylglycerol of the Formula 2 in the specification and an acetylating agent; and separating the optically active 1-palmitoyl-3-acetylglycerol by crystallizing the reaction mixture in a saturated hydrocarbon solvent having 5 to 7 carbon atoms. | 2014-08-28 |
20140243549 | NATURAL OIL BASED GELS, APPLICATIONS AND METHODS OF PREPARATION - The present invention relates to novel non-aqueous gels of natural oils and their derivatives and provides a novel process for the gelation of natural oils and their derivatives that does not require the addition of gellants or the irreversible heat bodying of the oil. The gels and method of the present invention are applicable to a wide range of natural oils, and the method is easily tailored to provide thermoreversible gels of any desired viscosity. The natural oil based gels of the present invention and the method of their preparation have many advantages over the prior art. The natural oil based gels provided have exemplary properties and find use in a variety of applications. | 2014-08-28 |
20140243550 | NATURAL OIL DERIVED GELLED INK VEHICLES - Novel natural oil derived ink vehicles are provided by a two step process that does not require the addition of gelants or the irreversible heat bodying or polymerization of the oil. The gelled natural oil may be used as the vehicle/carrier in the ink formulation or alternatively used as a carrier or dispersant for additives in ink formulations. The gelled ink vehicles disclosed have many advantages over ink vehicles disclosed in the prior art. | 2014-08-28 |
20140243551 | METHOD OF ISOLATING INGENOL - The present invention relates to a new method for isolating ingenol (C | 2014-08-28 |
20140243552 | EMULSIFYING AGENT FOR EMULSION POLYMERIZATION - A reactive emulsifier comprising a compound of formula (I), which makes polymerization stability satisfactory and is capable of improving the water resistance etc. of the polymer film to be obtained. | 2014-08-28 |
20140243553 | AMORPHOUS ASIATIC TROMETHAMINE SALT AND PREPARATION METHOD THEREOF - An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art. | 2014-08-28 |
20140243554 | METHOD FOR PREPARING ACRYLIC ACID FROM PROPANE AND PROPYLENE - The application concerns a process comprising: (A) contacting a gas comprising oxygen, propane and propylene with at least one catalyst under reaction conditions sufficient to at least partially convert the propylene into a final product comprising acrylic acid; (B) feeding said final product to a separation column, in which the final product is split into a liquid stream, which is rich in acrylic acid, and a gaseous by-product stream comprising propane and propylene in a volume ratio of from 99.9:0.1 to 95:5; (C) contacting the gaseous by-product stream with oxygen in the presence of a catalyst under reaction conditions sufficient to at least partially convert propane to acrylic acid. | 2014-08-28 |
20140243555 | METHOD FOR THE SYNTHESIS OF 18F-LABELLED MOLECULES - The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised. | 2014-08-28 |
20140243556 | CONTINUOUS TWO STEP FLOW SYNTHESIS OF M-AMINO ACETOPHENONE - Disclosed herein is a continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at −10 to 10° C. followed by reduction to m-nitrophenone resulting in uniform output of product, said process comprising the steps of: a) Nitrating acetophenone with nitrating agent (nitration mixture or fuming nitric acid) at −10 to 10° C.; b) Isolating m-nitro acetophenone from a mixture of o and m-nitro acetophenone and c) Reducing the m-nitro to obtain m-amino acetophenone. | 2014-08-28 |
20140243557 | POLYAMINES AND PROCESS FOR PREPARATION THEREOF - The present invention relates to polyamines and to a process for preparing polyamines. | 2014-08-28 |
20140243558 | NOVEL HYDROFORMYLATION PROCESS - The present invention relates to a process for producing 4-hydroxybutyraldehyde, characterized in that allyl alcohol dissolved in polar solvents is reacted with CO and H2 in the presence of a catalytic system which is formed from a rhodium complex and a cyclobutane ligand which contains at least two trans-coordinated 1,3-dialkylphenyl-phosphinomethyl groups, with the exclusion of catalysts which contain an aliphatic, araliphatic or cycloaliphatic phosphine as ligand. In which R | 2014-08-28 |
20140243559 | PROCESS FOR PREPARING POLYETHER POLYOLS - The present invention relates to a process for preparing polyether polyols by base-catalyzed addition of alkylene oxides (epoxides) onto starter compounds which are solid at room temperature and have Zerevitinov-active hydrogen atoms, a particular feature of which is that visually clear and/or homogeneous products are obtained even in the absence of solvents. | 2014-08-28 |
20140243560 | PROCESS FOR PREPARING POLYETHER POLYOLS - The present invention relates to a process for solvent-free preparation of polyether polyols with blockwise polyether chain structure, based on starter compounds solid at room temperature. | 2014-08-28 |
20140243561 | PROCESS FOR PREPARING 2,2-DIFLUOROETHANOL - Process for preparing 2,2-difluoroethanol, comprising the following steps: reacting 1-chloro-2,2-difluoroethane with an alkali metal salt of formic acid or acetic acid in a suitable solvent to give the corresponding 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate, and transesterifying the 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate from step (i) in the presence of an alcohol and optionally of a base. | 2014-08-28 |
20140243562 | HYDROGENOLYSIS OF FURFURYL ALCOHOL TO 1,2-PENTANEDIOL - The present invention provides a process for preparing 1,2-pentanediol by reacting furfuryl alcohol with hydrogen in the presence of a catalyst system. The catalyst system contains platinum oxide or contains ruthenium supported on aluminum oxide or activated carbon. The invention also relates to the respective catalysts and processes for producing the catalyst system. | 2014-08-28 |
20140243563 | METHOD FOR THE ALKYLATION OF RESIDUAL HYDROCARBONS OBTAINED FROM PYROLYTIC PROCESSES - The invention relates to a method for the alkylation of residual hydrocarbons obtained from pyrolytic processes, in particular processes for the obtaining of synthesis gas from wet crushed coal, essentially alkene- and alkane-type waste products, in order the exploit the energy thereof in the form of alkenes, alkanes and alcohols having a high energy content. The method is essentially characterised in that the waste products obtained from the synthesis gas formation are subject to a subsequent treatment in order to transform them into other branched alkane-type products and alcoholic compounds, recovering the hydrogen and water produced in said reactions, that remain available for their subsequent use as fuel in other chemical processing plants, or to be fed back to the gasification-pyrolysis process itself, to enrich the synthesis gas obtained. | 2014-08-28 |
20140243564 | METHOD FOR INHIBITING FOULING IN BASIC WASHING SYSTEMS - Fouling in basic washing systems such as caustic scrubbers can be prevented or at least mitigated by treating the liquid washing phase used in a caustic scrubber with an additive having at least one compound selected from the group consisting of oxalyl dihydrazide, a disulfite salt, isopropyl hydroxylamine, chlorobenzhydrazide, aminobenzhydrazide, a thiosulfate salt, 4,4-dimethyl oxazolidine, a hydrosulfite salt, and mixtures thereof, particularly in the case where the liquid washing phase includes components that may undergo an aldol condensation, the products of which may cause fouling solids and/or sludges. | 2014-08-28 |
20140243565 | PROCESS FOR PRODUCING BIOHYDROCARBONS - A process for producing biohydrocarbons, comprising the steps of | 2014-08-28 |
20140243566 | METHOD AND APPARATUS FOR REDUCING AN AROMATIC CONCENTRATION IN A HYDROCARBON STREAM - Methods and apparatuses for reducing an aromatic concentration in a hydrocarbon stream are provided. In an embodiment, a method for reducing an aromatic concentration in a hydrocarbon stream includes saturating aromatics in the hydrocarbon stream to form a low aromatic hydrocarbon stream comprising no more than about 2 weight percent (wt %) aromatics. Further, the method includes passing the low aromatic hydrocarbon stream through an adsorption zone to remove aromatics therefrom to form an aromatic-depleted product stream comprising less than about 10 weight parts per million (wppm) aromatics. | 2014-08-28 |
20140243567 | Liquid Phase Alkylation Process - The present invention provides a process for producing a monoalkylated benzene comprising the step of contacting benzene with an alkylating agent in the presence of a catalyst composition under effective alkylation conditions to form said monoalkylated benzene and polyalkylated benzene, said catalyst composition comprising MCM-56 and a binder, such that the crystal/binder weight ratio in said catalyst composition is from about 20/80 to about 80/20, wherein said polyalkylated benzene comprises dialkylated benzene and trialkylated benzene, and the weight ratio of trialkylated benzene to dialkylated benzene is in the range from about 0.08 to about 0.12. | 2014-08-28 |
20140243568 | Method for Making a Catalyst Comprising a Phosphorous Modified Zeolite and Use of Said Zeolite - A method to make a phosphorus modified zeolite can include providing a zeolite including at least one ten member ring in the structure steaming the zeolite, mixing the zeolite with one or more binders and shaping additives, and then shaping the mixture. The method can include making a ion-exchange. The shaped mixture can be steamed. Phosphorous can be introduced on the catalyst to introduce at least 0.1 wt % of phosphorus, such as be dry impregnation or chemical vapor deposition. A metal, such as calcium, can be introduced. The catalyst can be washed, calcinated, and then steamed. The steaming severity (X) can be at least about 2. The catalyst can be steamed at a temperature above 625° C., such as a temperature ranging from 700 to 800° C. The catalyst can be used in alcohol dehydration, olefin cracking, MTO processes, and alkylation of aromatics by alcohols with olefins and/or alcohols. | 2014-08-28 |
20140243569 | PROCESS AND ROTARY MACHINE TYPE REACTOR - A rotary machine type shock wave reactor suitable for thermal cracking of hydrocarbon-containing materials includes a casing, a rotor whose periphery contains an axial-flow blade cascade, and a directing rim, provided with at least two stationary vane cascades, adjoining an axial-flow rotor cascade, wherein the casing substantially encloses the periphery of the rotor and the directing rim. The cascades are configured to direct feedstock containing process stream to repeatedly pass the cascades in a helical trajectory while propagating within the duct between the inlet and exit and to generate stationary shock-waves to heat the feedstock. The axial-flow rotor cascade is configured to provide kinetic energy and add velocity to feedstock containing process stream, and the stationary vanes located downstream the rotor cascade are configured to reduce the velocity of the stream and convert kinetic energy into heat. The reactor may also process carbohydrate- and glyceride-based feedstock, and gaseous biomass matter. | 2014-08-28 |
20140243570 | Use of a Catalyst Comprising a Phosphorous Modified Zeolite in an Alcohol Dehydration Process - A catalyst can be used to convert an alcohol in a dehydration process into an olefin having the same number of carbon atoms as the alcohol. The catalyst can include a phosphorus modified zeolite made by providing a zeolite with at least one ten member ring in the structure, steaming the zeolite, mixing the zeolite with binders and shaping additives, and shaping the zeolite. An ion-exchange step can be performed, and the shaped catalyst can be steamed. Phosphorus can be introduced on the catalyst at an amount of at least 0.1 wt %, such as by dry impregnation or chemical vapor deposition. A metal can be introduced. The catalyst can be washed and/or calcinated, and steamed in an equilibration step. The steaming severity (X) can be at least about 2. The catalyst can be steamed at a temperature above 625° C., such as a temperature ranging from 700 to 800° C. | 2014-08-28 |
20140243571 | SAND SEPARATOR - An apparatus and method for separating a natural gas production stream from hydrocarbon well operations into a gas component and a sand and liquid component is described. More specifically, a sand separator comprising a cylindrical body, a production stream inlet port, a gas outlet port and a solid and liquid drain port is described. The cylindrical body has an inner cavity with an inner cone having one-way gas vents and a stationary auger wrapped around the inner cone. The production stream inlet port includes a pipe having a curved tip that directs the production stream into the body and around the inner cone and stationary auger, causing the production stream to slow down and the components to separate. | 2014-08-28 |
20140243572 | HYBRID MEMBRANE SYSTEM FOR GAS STREAMS WITH CONDENSABLE HYDROCARBONS - A gaseous component is extracted non-cryogenically from a feed gas containing condensable hydrocarbons. The feed gas is passed first through a module containing polymeric fibers useful for removing water vapor from the gas. The gas is then passed through a module containing polymeric fibers selected such that they remove some, but not all, of the carbon dioxide in the stream. The gas is then passed through a module containing polymeric fibers selected to remove at least some of the remaining carbon dioxide as well as heavy hydrocarbons, defined as C5 and heavier, from the stream. The invention is especially useful in processing raw methane taken from a well, and in producing methane which is relatively free of water vapor, carbon dioxide, and heavy hydrocarbons. | 2014-08-28 |
20140243573 | OIL QUALITY USING A MICROPOROUS HOLLOW FIBER MEMBRANE - The present invention includes methods and systems for improving oil quality of a contaminated oil mixture by removing contaminants from a contaminated oil comprising the steps of: pretreating a membrane contactor system having a first and a second surface with an hydrophobic liquid, wherein the hydrophobic liquid is contacted to at least one of the first and second surfaces; obtaining a contaminated oil that comprises oil and lipophobic contaminants; contacting the contaminated oil onto a first surface of one or more membrane contactors to coalesce the oil on the first surface; and collecting the coalesced oil from the contaminated oil on the second surface of the membrane contactor. | 2014-08-28 |
20140243574 | Helium Recovery From Natural Gas - Helium-containing natural gas is processed with three gas separation stages to produce a natural gas product and a Helium-containing gas that may be injected into the reservoir from which the Helium-containing natural gas is obtained. A permeate from the first gas separation membrane stage is compressed and fed to the second gas membrane stage. The permeate from the second gas separation membrane stage is recovered as the Helium-containing gas that may be injected into the reservoir. The non-permeate from the second gas separation membrane stage is fed to the third gas separation membrane stage. Non-permeates from the first and third gas separation stages are combined to produce a natural gas product. A permeate from the third gas separation membrane stage is combined with a non-permeate from the first gas separation membrane stage before it is compressed and fed to the second gas separation membrane stage. | 2014-08-28 |
20140243575 | METHOD OF REMOVING ASBESTOS FROM ASBESTOS-CONTAINING MATERIALS BY 99% THROUGH LOW TEMPERATURE HEAT TREATMENT - Disclosed is a method of removing asbestos from an asbestos-containing material by 99% through low temperature heat treatment. The method includes mixing an asbestos-containing material with an oxalic acid at a weight ratio in a range of 1:0.002 to 1:1 and performing heat treatment with respect to a mixture at a temperature of 90° C. to 110° C. to remove asbestos from the asbestos-containing material by 99% or more. | 2014-08-28 |
20140243576 | PARTICLE ACCELERATOR AND MEDICAL EQUIPMENT - One embodiment of a particle accelerator includes: a particle source from which a particle beam is extracted with a beam pulse width of not greater than 2 μsec; a linear accelerator for accelerating the particle beam extracted from the particle source; a synchrotron for receiving the particle beam transported thereto from the linear accelerator and causing the particle beam to circulate in order to accelerate it until it gets to a predetermined energy level; a bump electromagnet for shifting the circulating path of the particle beam each time it makes a full turn; and a control unit for controlling the extent of magnetic excitation of the bump electromagnet and for controlling the timing of magnetic excitation of the bump electromagnet according to the pulse timing of the particle source. | 2014-08-28 |
20140243577 | Combined Organ and Hematopoietic Cells For Transplantation Tolerance of HLA Mismatched Grafts - Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance. | 2014-08-28 |
20140243578 | RADIOWAVE TREATMENT FOR CANCER - A method of treating cancer in an adult subject comprising an electromagnetic (EM) radiation treatment step of administering to the subject an effective dose of EM radiation of a frequency in the range of 430-440 MHz (UHF) within a period of ≦45 minutes, the EM radiation being provided by a UHF emitter defining an exposure region, wherein for the duration of the period the subject is reclined upon a horizontal or substantially horizontal surface, and wherein the surface and UHF emitter are arranged for relative movement such that the exposure region passes, continually or periodically, between a first position and at least a second position on the subject. The method may further comprise an auxiliary treatment step such as X-ray therapy or treatment with certain chemical agents such as oxidised glutathione (GSSG) and/or a precursor thereof (eg glutathione (GSH)) in combination with a non-toxic oxidising agent, and S-methyl-L-cysteine sulphoxide (SMCO) | 2014-08-28 |
20140243579 | DUAL-ENERGY IMAGE SUPPRESSION METHOD - An imaging process capable of selectively enhancing visualization of soft tissues, for example, a tumor. The imaging process includes producing a hard tissue-enhanced image of a body containing both soft and hard tissues, wherein the hard tissue-enhanced image contains images of the hard tissues that are enhanced relative to the soft tissues. A radiographic image of the body and the soft and hard tissues thereof are then obtained, after which a weighted subtraction algorithm is performed between the radiographic image and the hard tissue-enhanced image to produce a soft tissue-enhanced image in which imaging of the soft tissues is enhanced relative to the hard tissues. The hard tissue-enhanced image may be produced by obtaining first and second initial radiographic images of the body including the soft and hard tissues, and then performing a weighted subtraction algorithm on the first and second initial radiographic images to produce the hard tissue-enhanced image. | 2014-08-28 |
20140243580 | ENDORECTAL BALLOON WITH GAS RELEASE LUMEN - A rectal balloon apparatus comprises a shaft having a fluid passageway extending therethrough. A rectal gas relieving lumen may be positioned with a central shaft for removal of rectal gas. The gas releasing lumen can also or in the alternative be provided along an outer surface of the balloon. A motion detecting sensor and a radiation detecting sensor may be positioned with the balloon, the shaft, and/or the rectal gas release lumen. | 2014-08-28 |
20140243581 | METHODS OF TREATING DNA DAMAGE - The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e., prevent or slow the aging process in all species. The treatment includes administering to the patient a pharmaceutical composition that includes carbon monoxide. | 2014-08-28 |
20140243582 | Inclined Beamline Motion Mechanism - A radiotherapy particle emitter positioning device is provided. The positioning device includes first and second arcuate support frames, a mounting carriage and a drive arrangement. The first and second arcuate support frames each include a drive track arrangement defining an arcuate carriage guide path. The mounting carriage is configured for supporting the radiotherapy particle emitter. The mounting carriage is mounted to and supported by the support frames. The mounting carriage is connectable to the drive track arrangements and moveable along the carriage guide path. The mounting carriage also includes the drive arrangement. The drive arrangement engages the drive track arrangements for driving the mounting carriage along the drive track arrangements and the carriage guide path. | 2014-08-28 |
20140243583 | METHOD FOR PREVENTING THE ONSET AND PROGRESSION OF MYOPIA - The present invention relates to ophthalmology, and is designated to prevent onset and progression of myopia. The treatment course, comprising eye exposure with magnetic field, transscleral low-energy laser radiation with wavelength of 1.3 microns, and additional optical—reflectory eye trainings, is conducted. The entire treatment course is 5 procedures every other day. initial badminton trainings are performed for 2 months three times a week for 2 hours. During the treatment course trainings are performed 2 times a week on days free of the treatment. on completing the treatment course trainings are performed 2-3 times a week for 1 year. The method makes it possible to reduce the length of the treatment and decrease the number of procedures—sessions of functional treatment of myopia with increasing and prolonging efficiency of prevention and treatment of myopia with increasing positive psychological attitude to the treatment of child. | 2014-08-28 |
20140243585 | SCREENING OF OOCYTE DONOR CANDIDATES BASED ON THE FMR1 GENE - Method of selecting oocyte donor candidates for oocyte donation. A number of triple CGG repeats on each allele of the isolated FMR1 gene is measured by using an assay, and an oocyte donor is selected for oocyte donation only if both alleles of the isolated FMR1 gene have more than 26 CGG repeats. | 2014-08-28 |
20140243586 | METHODS AND SYSTEMS FOR MAGNETICALLY SUSPENDING TISSUE STRUCTURES - A system for magnetically suspending tissue includes a grasper placement tool, a tissue grasper, a magnetic coupling element, and a tether which secures the magnetic coupling element to the tissue grasper. The grasper placement tool is used to simultaneously introduce both the tissue grasper and the magnetic coupling element to a body cavity. The grasper then releases the magnetic coupling element and engages a target tissue structure. The tissue grasper is then detached from the placement tool and a conventional laparoscopic or other grasper is used to engage the magnetic coupling element to an external magnet. | 2014-08-28 |
20140243587 | METHODS AND SYSTEMS FOR MAGNETICALLY SUSPENDING TISSUE STRUCTURES - A system for magnetically suspending tissue includes a grasper placement tool, a tissue grasper, a magnetic coupling element, and a tether which secures the magnetic coupling element to the tissue grasper. The grasper placement tool is used to simultaneously introduce both the tissue grasper and the magnetic coupling element to a body cavity. The grasper then releases the magnetic coupling element and engages a target tissue structure. The tissue grasper is then detached from the placement tool and a conventional laparoscopic or other grasper is used to engage the magnetic coupling element to an external magnet. | 2014-08-28 |
20140243588 | IMPLANTABLE STOMA RING - The present invention relates to a ring ( | 2014-08-28 |
20140243592 | MECHANICAL STRUCTURE OF ARTICULATED SHEATH - A sheath apparatus includes, a plurality of node rings configured to be tilted with respect to each other, each node ring defining a substantially cylindrical wall and having at least one hole passing through said cylindrical wall, the plurality of node rings being arranged next to each other along a linear axis such that consecutive node rings contact each other at a contact plane; a manipulating wire going through the holes in said stacked node rings; and a position restoring component configured to restore said stacked node rings from a tilted position to an original position, wherein said position restoring component is located inside or outside of the stacked node rings. | 2014-08-28 |
20140243593 | Implantable Electrical Stimulation Leads - An implantable electrical stimulation lead for the treatment of biological conditions includes a lead body with an electrical connector at one end and a pair of monopolar branches at the other end. The lead body has a length ranging from 390 mm to 490 mm to allow for implantation from an incision site further removed from the final positioning site of the electrodes. The branches have lengths ranging from 50 mm to 120 mm for the both branches. These lengths facilitate successful laparoscopic implantation at sites with confined anatomy, such as, near the gastroesophageal junction. The branches include needles and sutures at their ends for suturing anchors positioned on the branches to surrounding tissue. The needles have curves designed to facilitate maneuvering in confined anatomy. A separate lead includes a suture loop connecting the ends of the first and second branches rather than needles. The loop is used to pull the lead through the working channel of an endoscope. The anchors on the lead are porous and allow for the ingrowth of surrounding tissue for fixing the branches in place. | 2014-08-28 |
20140243594 | MEDICAL DEVICE ACTUATION SYSTEMS AND RELATED METHODS OF USE - A medical system including an endoscope having a proximal end, a distal end, and a lumen extending therebetween is disclosed. The endoscope includes a port configured to provide access to the lumen. In addition, the system may include an actuation member slidably disposed through the lumen such that a proximal end of the actuation member extends through the port, and a distal end of the actuation member is operably coupled to an end-effector. The system may further include an actuation handle removably secured to the actuation member. In one embodiment, a portion of the end-effector has dimensions larger than a maximum dimension of the lumen. | 2014-08-28 |
20140243595 | ELECTRONIC ENDOSCOPE AND METHOD OF MANUFACTURING ELECTRONIC ENDOSCOPE - The electronic endoscope includes: an image pickup element that receives incident light; a circuit board on which the image pickup element and a drive circuit component for the image pickup element are mounted; a plurality of internal signal lines electrically connected to the circuit board; an airtight structure including an airtight container and an airtight terminal through which a plurality of terminal pins penetrate, the airtight structure airtightly sealing therein the image pickup element, the circuit board, and the plurality of internal signal lines; and a signal line cable including a plurality of signal lines, the signal line cable being placed outside of the airtight structure. The electronic endoscope further includes a pipe-shaped electrically conductive member that electrically connects each of the plurality of signal lines of the signal line cable and each of the plurality of terminal pins placed outside of the airtight structure. | 2014-08-28 |
20140243596 | ENDOSCOPE SYSTEM AND CONTROL METHOD THEREOF - Disclosed herein are an endoscope system and a control method thereof. The control method includes acquiring plural omnidirectional images of the surroundings of an endoscope using a stereo omnidirectional camera mounted on the endoscope, calculating distances between the endoscope and an object around the endoscope using the acquired plural omnidirectional images, and executing an operation to avoid collision between the endoscope and the object around the endoscope based on the calculated distances, thus facilitating safe operation of the endoscope. | 2014-08-28 |
20140243597 | SYSTEM FOR PERFORMING A MINIMALLY INVASIVE SURGICAL PROCEDURE - A surgical system for performing a surgical procedure includes an ex-vivo positioning mechanism and an in-vivo instrument magnetically attracted to the ex-vivo positioning mechanism. The in-vivo instrument can be positioned within a patient by moving the ex-vivo positioning mechanism. In addition, the surgical system includes a percutaneous member introducible into the patient independent from the ex-vivo positioning mechanism, the percutaneous member comprising a connector at a distal end thereof, wherein the connector is selectively couplable to the in-vivo instrument within the patient. | 2014-08-28 |
20140243598 | OPTICAL PROBE DELIVERY AND RETRIEVAL SYSTEMS AND METHODS - Optical probe delivery and retrieval systems and methods are disclosed. The optical probe includes a dissolvable capsule that contains micro-components that are substantially smaller than the size of the capsule. The capsule is allowed to dissolve in the stomach after imaging data is collected in the esophagus. Thus, only the optical fiber tether and the relatively small micro-components attached thereto need be retrieved. Delivery devices that facilitate comfortable delivery and retrieval of the optical probe are also disclosed. | 2014-08-28 |
20140243599 | SURGICAL TOOL INTRODUCER - A tool introducer is configured for introduction in an elongated body including a straight tube, wherein the tube encloses a tube lumen opened at its distal end with a tube opening. The tool introducer includes locking means to selectively lock or unlock an interchangeable surgical tool to the tube from displacing axially and/or rotationally in the tube lumen, the locking means being configured such that, at the locking, a tool connector of the tool projects towards the tube opening and is distanced therefrom by at least 3 cm. A method includes positioning the surgical tool introducer such that a distal portion thereof projects in a body cavity, manipulating and/or extending the tool introducer to reach and engage an elongated shaft introduced percutaneously into the body cavity; and inserting the elongated shaft into the tube lumen via the tube opening and connecting the tool to the elongated shaft. | 2014-08-28 |
20140243600 | OXYGEN MASK ADAPTABLE FOR UPPER GASTROINTESTINAL (UGI) ENDOSCOPY PROCEDURES PROVIDING ENHANCED OXYGEN CONCENTRATION TO MAINTAIN PATIENT OXYGENATION - An oxygen mask adaptable for upper gastrointestinal (UGI) endoscopy procedures providing enhanced oxygen concentration to maintain patient oxygenation. An oxygen mask in accordance with the present invention provides an aperture of sufficient dimensions to enable substantially unimpeded placement and manipulation of an endoscope during an endoscopic procedure while an overlying closure is in an open position and yet may also be closed to cover the aperture when the procedure is not being performed. | 2014-08-28 |
20140243601 | Flexible Access Assembly - A cannula assembly includes a cannula and an obturator. The cannula includes an elongated shaft dimensioned to access tissue. The elongated shaft has a lumen extending therethrough. The elongated shaft includes a first shaft segment having a first pre-determined configuration and a second shaft segment having a second pre-determined configuration different from the first pre-determined configuration. The obturator includes an elongated body adapted for insertion through the lumen of the elongated shaft. The elongated body includes a first body segment having a configuration in general accordance with the first pre-determined configuration of the first shaft segment and a second body segment selectively adaptable to conform to the second pre-determined configuration of the second shaft segment upon insertion through the lumen of the elongated shaft. | 2014-08-28 |
20140243602 | MINIMALLY INVASIVE RETRACTOR SCREW AND METHODS OF USE - A device, system and method for orthopedic spine surgery using a novel screw-based retractor, disclosed herein, that allows for access to the spine through a minimally or less invasive approach. The retractor device is designed as an integrally formed part of the tulip of a pedicle screw assembly with opposed arms of the retractor spread apart to open the wound proximally. The arms are removed by separating the arms from the tulip and pulling it out of the wound. The retractor device is intended to be made of a stiff material, sterile packaged and disposable after one use. A system and method for using the retractor and performing a minimally invasive spine surgical procedure are also disclosed. | 2014-08-28 |
20140243603 | ACCESS ASSEMBLY INSERTION DEVICE - An improved access assembly is provided. The access assembly includes an inflatable port and an inflation cannula operably connected to the inflatable port to provide inflation fluid to the inflatable port. The inflatable port may be tapered in a first configuration to facilitate insertion through tissue. The inflation port defines a substantially hour-glass shape when in a second configuration to create a seal within an opening in the tissue. | 2014-08-28 |
20140243604 | Surgical Access Tube - Implementations of the present disclosure provide an access tube including a wall structure and an optional handle extending from the wall structure. Selectively weakened areas facilitate selective resection of the wall structure to reveal windows that accommodate lateral intrusions by surrounding anatomical structures and/or provide increased access to an intervertebral disc. For example, a first distal weakened portion is configured to form a first window to afford lateral intrusion of a spinous process. A second distal weakened portion is configured to form a second window to afford lateral intrusion of facet. A proximal weakened portion is configured to afford additional angular access on a proximal end of the tube. | 2014-08-28 |
20140243605 | MINIMALLY INVASIVE RETRACTOR AND METHODS OF USE - A device, system and method for orthopedic spine surgery using a novel screw-based retractor, disclosed herein, that allows for access to the spine through a minimally or less invasive approach. The retractor device is designed to be coupled to a pedicle screw and then to have opposed arms of the retractor spread apart to open the wound proximally. The retractor is removed by pulling it out of the wound whereby the retractor is deformed to pass over the pedicle screw head. The retractor is intended to be made of a stiff plastic material, sterile packaged and disposable after one use. A system and method for using the retractor and performing a minimally invasive spine surgical procedure are also disclosed. | 2014-08-28 |
20140243606 | Retraction of the Left Atrial Appendage - A clamp is provided for attachment to the left atrial appendage (LAA). The clamp can be locked in a closed position so as to remain in place on the LAA. After being attached to the LAA, the clamp can be moved to a desired position such that the LAA can be retracted to a desired extent. The clamp can be held in any desired position, preferably by being connected to a thoracic retractor that is being used to retract the patient's sternum or ribs. A movable member is connected between the clamp and a stationary portion of the retractor. By locking the movable member in a fixed position relative to the stationary portion, the clamp can be maintained in a desired position and the LAA can be retracted as desired. | 2014-08-28 |