35th week of 2014 patent applcation highlights part 50 |
Patent application number | Title | Published |
20140242599 | MATERIALS AND METHODS FOR DETERMINING SENSITIVITY POTENTIAL OF COMPOUNDS - The invention concerns in vitro proteomic analysis of cells to determine the sensitizing potential (including allergic potential) of compounds on said cells. Several protein markers are provided that allow assays to be performed to determine whether a chemical has a sensitizing potential of contact sensitizers. | 2014-08-28 |
20140242600 | IMAGING THE HETEROGENEOUS UPTAKE OF RADIOLABELED MOLECULES IN SINGLE LIVING CELLS - A radioluminescence microscopy system and method for imaging the distribution of radiolabeled molecules in live cell cultures and tissue sections. Cells are grown and incubated with radiolabeled molecules on a scintillator plate or a scintillator plate is placed adjacent to the cells after incubation. Scintillation light produced by decay of radiolabeled molecules inside, bound to, or surrounding the cells, is recorded on an imaging device. Fluorescence microscopy of the same cells with other types of molecules of interest that are labeled with different fluorophores can be conducted concurrently and the biological activity of the labeled molecules can be correlated. | 2014-08-28 |
20140242601 | MOLECULARLY IMPRINTED POLYMER-BASED PASSIVE SENSOR - Systems and methods for the detection of one or more target molecules emitted from microbial sources are described. The systems and methods may include a molecularly imprinted polymer film; a strain sensitive surface, wherein the molecularly imprinted polymer film comprises a polymer host with one or more binding sites for one or more target molecules. The molecularly imprinted polymer film may be coated upon the strain sensitive surface. | 2014-08-28 |
20140242602 | USES OF LABELED HSP90 INHIBITORS - The disclosure provides evidence that the abundance of this particular “oncogenic HSP90” species, which is not dictated by HSP90 expression alone, predicts for sensitivity to HSP90 inhibition therapy, and thus is a biomarker for HSP90 therapy. The disclosure also provides evidence that identifying and measuring the abundance of this oncogenic HSP90 species in tumors predicts of response to HSP90 therapy. “Oncogenic HSP90” is defined herein as the HSP90 fraction that represents a cell stress specific form of chaperone complex, that is expanded and constitutively maintained in the tumor cell context, and that may execute functions necessary to maintain the malignant phenotype. Such roles are not only to regulate the folding of overexpressed (i.e. HER2), mutated (i.e. mB-Raf) or chimeric proteins (i.e. Bcr-Abl), but also to facilitate scaffolding and complex formation of molecules involved in aberrantly activated signaling complexes (i.e. STATS, BCL6). | 2014-08-28 |
20140242603 | METHODS AND APPARATUS FOR TARGET CELL MAGNETIC ENRICHMENT, ISOLATION AND BIOLOGICAL ANALYSIS - Disclosed here are methods and apparatus for target cell magnetic enrichment, isolation, and biological analysis. The target cells are labeled with magnetic nano-particles in a separate tube, container or in a device with soft magnetic collectors but not activated during the labeling period. Labeled biological samples will be used for targets enrichment and isolation using a magnetic device (permanent magnet or electromagnet). The labeled sample passes through a tube/channel within a magnetic field so the magnetic nano-particle labeled targets can be captured. Once the magnetic field is turned off, the captured targets can be released in a container. The labeling of the targets also can be performed in a device with soft magnetic collectors inside. Without magnetic activation, the device is just like a regular biological sample incubator. Thus the targets are labeled during the mixing and incubation. Once the device is placed in the magnetic field, the soft magnetic collectors are activated and the labeled target cells are isolated. After the washing process, the pure targets are released into the target collector by turning off the magnetic field with or without centrifugation. The magnet can be a permanent magnet or an electromagnet producing the magnetic field for targets to bind to the soft magnetic collectors in the device. The soft magnetic collectors can function as a magnet for capturing and releasing targets without the need of separation covers between magnet and target biological structures. The methods and apparatus improve the targets capturing sensitivity which improves the operation of the device. The methods and apparatus can be used for enrichment, isolation and material transferring. | 2014-08-28 |
20140242604 | ULTRA-FAST PATHOGEN TOXIN DETECTION ASSAY BASED ON MICROWAVE-ACCELERATED METAL-ENHANCED FLUORESCENCE - The present invention provides for a system and method to detect low levels of the anthrax protective antigen (PA) exotoxin in biological fluids, wherein the system uses a metal-enhanced fluorescence (MEF)-PA assay in combination with microwave-accelerated PA protein surface absorption. Microwave irradiation rapidly accelerates PA deposition onto the surface adjacent to deposited metallic particles and significantly speeding up the MEF-PA assay and resulting in a total assay run time of less than 40 min with an analytical sensitivity of less than 1 pg/ml PA. | 2014-08-28 |
20140242605 | Heat-Transfer Resistance Based Analysis of Bioparticles - A bio-sensing device suitable for the detection and/or characterization of target bioparticles and corresponding method is described. The bio-sensing technique is based on the impact on the heat transfer resistivity value of bioparticles binding in binding cavities of a structured substrate. By sensing temperatures and determining a heat transfer resistivity value based thereon, a characteristic of the target bioparticles can be derived. | 2014-08-28 |
20140242606 | PROBE FOR iFRET AND USE THEREOF - The present invention relates to a probe for iFRET and use thereof. Specifically, the present invention relates to a novel probe for iFRET, a method for preparing the probe for iFRET, a method for searching a target protein-specific binding site or a molecule having the binding site using the probe for iFRET, and a method for imaging the target protein using the probe for iFRET. The probe for iFRET according to the present invention utilizes an amino acid in a protein as a fluorescent donor, unlike the conventional FRET method. Therefore, only one fluorescent material is used, and its emission wavelength is distinct from the intrinsic fluorescence of the protein. Thus, high specificity and sensitivity are ensured, and the quantity, activity and mechanism of various proteins can be analyzed in an easy and accurate manner. | 2014-08-28 |
20140242607 | ANTIBODY FOR DETECTING EPITHELIAL OVARIAN CANCER MARKER AND METHOD FOR DIAGNOSING EPITHELIAL OVARIAN CANCER - It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-β1,6-N-acetylglucosaminyltransferase 5B antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of a glycosyltransferase β1,6-N-acetylglucosaminyltransferase 5B as an epithelial ovarian cancer marker. The antibody recognizes, as an epitope, a part of a polypeptide of the enzyme consisting of the amino acid sequence represented by SEQ ID NO: 1. | 2014-08-28 |
20140242608 | COMPOSITION FOR DIAGNOSIS OF LUNG CANCER AND DIAGNOSIS KIT FOR LUNG CANCER - The present invention provides serum paraoxonase 1 protein as a biomarker useful for early diagnosis of lung cancer. | 2014-08-28 |
20140242609 | Diagnosis and treatment of kidney stones, methods and compositions therefor - Methods of detecting, diagnosing, monitoring and treating kidney stones are disclosed. In some embodiments, methods of detecting, diagnosing or monitoring kidney stones comprise contacting a urine sample with anti-Claudin-14 antibody, and detecting quantity of a complex comprising Claudin-14 and the antibody, wherein an increase compared to control levels is diagnostic for kidney stones. In some embodiments, methods further comprise testing a second sample at a second time point to detect increased kidney stones. In some embodiments, methods of treating kidney stone disease comprise administering an miR-9 mimic or an miR-374 mimic. In some embodiments, methods comprise administering an inhibitor of CaSR signaling. In some embodiments, methods comprise administering a HDAC inhibitor. In some embodiments methods of treating hyperparathyroidism and hypercalcemia are disclosed, comprising administering an agonist of CaSR. Methods of abrogating CaSR-mediated regulation of claudin-14, microRNAs and urinary Ca++ excretion are disclosed, comprising administering a calcineurin inhibitor. | 2014-08-28 |
20140242610 | Methods and Compositions for Cytometric Detection of Rare Target Cells in a Sample - The present disclosure provides cytometric methods for the detection of rare target cells in a sample. In certain aspects, the methods and compositions may facilitate the detection of rare target cells, such as circulating tumor cells (CTCs), in a biological sample such as blood. Aspects of the methods include contacting the sample with first and second binding members that specifically bind to a marker of the rare target cell, and cytometrically assaying the sample for the presence of cells comprising bound first and second binding members to detect the rare target cell in the sample. Also provided are systems, compositions, and kits for practicing the subject methods. | 2014-08-28 |
20140242611 | METHOD FOR DETECTING AND/OR QUANTIFYING AN ANALYTE AT THE SURFACE OF A CELL - The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein. | 2014-08-28 |
20140242612 | SYSTEM AND METHOD FOR INTEGRATION OF MOBILE DEVICE IMAGING WITH MICROCHIP ELISA - A system and method for analyzing a biomarker in a biological sample is provided. A biological sample is loaded onto a microchip and an enzyme-linked immunosorbent assay specific to the biomarker is performed on the microchip. A color image of the microchip is generated using a mobile device and a color intensity of a selected portion of the color image is determined. The color intensity is correlated with a biomarker concentration using a baseline curve calculation and the concentration of the biomarker is then reported. | 2014-08-28 |
20140242613 | RAPID IDENTIFICATION OF ORGANISMS IN BODILY FLUIDS - There is provided a lateral flow assay that can provide an indication of Gram negative (GN) or Gram positive (GP) infection (or both) within 30 minutes, and desirably in less than 15 minutes. The immediate result would signal the presence of Gram negative bacteria, Gram positive bacteria, both Gram negative and Gram positive bacteria, or no bacteria detected. The detection level would be above a specific bacterial concentration threshold that is clinically significant infection source (e.g. 10̂3 cfu/ml) versus the presence of a colonizing bacteria that is not a part of the active infection. | 2014-08-28 |
20140242614 | MAGNETIC AGGREGATING AND WASHING DEVICE FOR IN VITRO ASSAYS AND METHODS OF USE THEREOF - Provided herein are magnetic aggregating and washing devices. Further provided herein are methods using magnetic aggregation to aggregate and wash sample molecules in an in vitro assay. | 2014-08-28 |
20140242615 | Methods and Reagents for Determining Isomeric Analytes - Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined. The first measurement value represents a total amount of the first isomeric analyte and the second isomeric analyte. The second measurement value represents an amount of the second isomeric analyte only. The second measurement value is subtracted from the first measurement value to obtain a resulting value and the resulting value is equated to an amount of the first isomeric analyte in the sample. | 2014-08-28 |
20140242616 | FREE NGAL AS A BIOMARKER FOR CANCER - Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed to measuring uncomplexed NGAL levels in urine as a primary screen to determine if an individual is either at risk of developing, or has developed cancer, e.g., cancer of epithelial origin including breast and ovarian cancer. | 2014-08-28 |
20140242617 | Immunoassay for Detecting Kratom, its Constituents and their Use - The invention relates to the field of drug detection and describes antibody-based components methods and kits for the detection and quantification of alkaloids of the plant kratom. The invention is underpinned by novel antibodies which specifically bind to mitragynine alkaloids found in the kratom plant and their metabolites. | 2014-08-28 |
20140242618 | Ritalinic Acid Immunoassay - The invention provides novel antibodies which specifically bind to the methylphenidate metabolite, ritalinic acid, enabling an immunoassay that can detect methyphenidate in biological samples for an extended period following its ingestion. The invention also describes novel conjugates and kits incorporating the antibodies. | 2014-08-28 |
20140242619 | EQUINE PARASITE DETECTION - The present invention provides a method of diagnosing a | 2014-08-28 |
20140242620 | METHOD OF INHIBITING NON-SPECIFIC BINDING IN STEP OF DETECTING SUBSTANCE IN BIOLOGICAL SAMPLE, AND AGENT FOR USE IN THE METHOD - The present invention provides a method of inhibiting non-specific binding in a step of detecting a substance in a biological sample. The invention provides a method of inhibiting non-specific binding in a step of detecting a substance in a biological sample, the method comprising:
| 2014-08-28 |
20140242621 | METHOD FOR DETERMINING PROTEIN S ACTIVITY - The invention relates to a method for determining the protein Ca-cofactor activity of protein S, wherein the protein Ca-cofactor activity of protein S is measured in a first reaction volume in the absence of a protein S inhibitor and in a second reaction volume in the presence of a protein S inhibitor. The protein Ca-cofactor activity of protein S is determined by calculating the quotient of the assay result of the first reaction volume and the assay result of the second reaction volume. | 2014-08-28 |
20140242622 | METHODS OF DETECTING TEST ELEMENTS HAVING DEGRADED TEST CHEMICALS AS WELL AS APPARATUSES INCORPORATING THE SAME - An analytical apparatus is disclosed for detecting at least one analyte in a sample, where in an analyte measurement at least an electrical or optical property changeable by presence of the analyte at least one test chemical of a test element is recorded, and where the analytical apparatus also can perform at least one quality measurement on the at least one test chemical such as an intrinsic luminescence, which is recorded and from the intrinsic luminescence a conclusion is drawn on a quality of the test chemical and thus the test element. Methods also are disclosed for detecting at least one analyte in a sample that include a quality measurement of the at least one test chemical of the test strip. | 2014-08-28 |
20140242623 | SIGNAL-RESPONSIVE PLASTICS - We disclose methods and compositions for preparation of stimuli-responsive plastics that are capable of responding to chemical and/or physical signals in their environment. In one embodiment the plastics consist of patterned mixtures of poly(phthalaldehyde) polymers in which each polymer contains a different end-capping group (also called a “trigger”), responsive to a different signal. Other embodiments use different polymers and different triggers. The plastics may be homogeneous in composition, but each polymer within the plastic is capable of responding to a different signal and depolymerizing once this signal reacts with the trigger. This process of depolymerization enables the plastic to alter its physical features non-linearly to external signals: i.e., the degree of change in physical form is much larger than the intensity of the initial signal. | 2014-08-28 |
20140242624 | INTACT MASS DETERMINATION OF PROTEIN CONJUGATED AGENT COMPOUNDS - The present invention provides methods and systems for the rapid determination of the intact mass of non-covalently associated antibody heavy chains (HC) and light chains (LC) which result from the attachment of drug conjugates to interchain cysteine residues. By analyzing the antibody-drug conjugate (ADC) using native desalting conditions, the intact-bivalent structure of the ADC, which ordinarily would decompose as a consequence of denaturing chromatographic conditions typically used for LCMS, is maintained. The mass of the desalted ADC is subsequently determined using desolvation and ionization ESI-MS conditions. The methods described herein provide for direct measurement of the intact mass of an ADC conjugated at interchain cysteine residues. The methods described herein also provide for the relative quantitation of the individual ADC species. | 2014-08-28 |
20140242625 | ANALYTICAL METHOD FOR FAB AND FAB' MOLECULES - A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab or Fab′ to provide isolated Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG. | 2014-08-28 |
20140242626 | NITRITE-REDUCTASE (NIRB) AS POTENTIAL ANTI-TUBERCULAR TARGET AND A METHOD TO DETECT THE SEVERITY OF TUBERCULOSIS DISEASE - The present invention discloses functional nitrite reductase as a potential drug target for anti-tubercular drug development. The present invention also relates to the development of an easy method for identification of nitrite in clinical samples as well as its correlation with the severity of the disease. Presence of active as well as dormant/latent stages of | 2014-08-28 |
20140242627 | STABILIZED FORMULATION FOR LUMINESCENT DETECTION OF LUCIFERASE AND NUCLEOSIDE PHOSPHATES - Methods, kits and compositions containing a mixture of D-luciferin and L-luciferin for light generation with luciferase are disclosed that have improved stability when stored over time. The mixture of D-luciferin and L-luciferin can be used to detect the presence or amount of ATP or of luciferase in a sample. | 2014-08-28 |
20140242628 | ANALYTICAL METHOD AND DEVICE FOR MALIC ACID - Analytical methods and devices according to the present disclosure may be used to assay the concentration of malic acid, or related species, in a sample, e.g., preparations of fruit, vegetables, juice, and/or wine. Liquid samples are combined with a reaction mixture, incubated, and a parameter characteristic of the resulting incubated mixture is measured. During the incubation, the reaction mixture generally reacts with the liquid sample to transform malic acid or related species that is present in the liquid sample. The measured parameter may be pressure, pH, an amount (e.g., volume, mass) of CO | 2014-08-28 |
20140242629 | Modulation of Angiogenesis - The invention provides methods for treating pathological conditions that can be improved by providing angiogenesis. The invention is generally directed to provide angiogenesis by administering cells that express and/or secrete one or more pro-angiogenic factors. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to express and/or secrete one or more pro-angiogenic factors. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired levels of expression and/or secretion of one or more pro-angiogenic factors. | 2014-08-28 |
20140242630 | Laser Microdissection Method and Apparatus - Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a polymer membrane which is then placed onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the biological material. In yet another variation, a sample of biological material is mounted onto a polymer membrane which is then inverted onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the polymer membrane. Then, an UV laser cuts along a cut path around the targeted portions of biological material in a closed cut path or a substantially closed cut path defining an interior and an exterior portion of the tissue sample. In a substantially closed cut path, bridges are left spanning the interior of the cut path and the exterior of the cut path. An IR laser activates at least a portion of the transfer film such that the transfer film in the vicinity of targeted portion adheres to the biological material interior to the cut path. The transfer film is then removed separating the targeted portions of biological material which are adhered to the transfer film from the remaining portion of the tissue sample. | 2014-08-28 |
20140242631 | NEW AND GREENER PROCESS TO SYNTHESIZE WATER-SOLUBLE MN2+-DOPED CDSSE(ZNS) CORE(SHELL) NANOCRYSTALS FOR RATIOMETRIC TEMPERATURE SENSING, NANOCRYSTALS, AND METHODS IMPLEMENTING NANOCRYSTALS | 2014-08-28 |
20140242632 | HYDROGEL PATTERNING AND TRANSFERRING METHOD OF CELLS, AND CELL-BASED BIOSENSOR USING SAME - Provided are a hydrogel-encapsulated cell patterning and transferring method comprising: preparing a substrate having a hydrogel-encapsulated cell patterning comprising a first cell and an alginate hydrogel; preparing an agarose hydrogel substrate comprising agarose hydrogel and any one of a second cell and a physiological active substance; and disposing the substrate having the hydrogel-encapsulated cell patterning on the agarose hydrogel substrate and transferring the cell patterning and a biosensor comprising: a first substrate having a hydrogel-encapsulated cell patterning comprising a first cell and an alginate hydrogel; and an agarose hydrogel second substrate comprising agarose hydrogel and any one of a second cell and a physiological active substance. | 2014-08-28 |
20140242633 | URINE SAMPLE ANALYZER AND SAMPLE ANALYZING METHOD - A urine analyzer capable of operating in a urine measurement mode and a body fluid measurement mode, the urine analyzer includes a specimen preparing section configured to prepare a measurement specimen and a detecting section configured to derive signals of particles in the measurement specimen supplied from the specimen preparing section. A computer and a memory including programs on a computer-readable medium that enable the computer to execute operations to control the specimen preparing section and the detecting section in the urine measurement mode and in the body fluid measurement mode. | 2014-08-28 |
20140242634 | Methods and Compositions for Hematoxylin and Eosin Staining - The present invention provide for solutions of a defined composition useful in a staining protocol, such as a hematoxylin and eosin staining protocol, when used at certain points of the staining protocol. The formulations of these defined solutions are such that carry-over of the solutions will not negatively impact, or preferably, will stabilize or favorably modify staining reagent solutions coming in contact with the solutions. In certain embodiments of the invention, solutions are buffered to maintain a specific pH that when carried-over—such as carried-over into hematoxylin—will not significantly influence the pH of the next staining reagent. | 2014-08-28 |
20140242635 | Fermentation Process for the Production of Diphtheria Toxin - The present invention relates to a fermentation process comprising a fermentation step of growing a strain of | 2014-08-28 |
20140242636 | REGULATABLE PROMOTER - A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate of at least 15% as compared to the native pGAP promoter, and c) producing and recovering the POI; and further an isolated regulatable promoter and a respective expression system. | 2014-08-28 |
20140242637 | ARTIFICIAL INTRONS - The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel artificial intron sequences. | 2014-08-28 |
20140242638 | TRANSCRIPTION UNIT AND USE THEREOF IN (YB2/0) EXPRESSION VECTORS - A transcription unit constituted by a polynucleotide including the hCMVie virus enhancer, the enhancer having the nucleotide sequence SEQ ID NO: 1, or a nucleotide acid having at least 70% sequence identity with the sequence SEQ ID NO: 1 and essentially having transcription activation properties, and the promoter region of Cyclin-Dependent Kinase 9 (CDK9), the promoter region having the nucleotide sequence SEQ ID NO: 2, or a nucleotide acid having at least 70% sequence identity with the sequence SEQ ID NO: 2 and essentially having a promoter activity. | 2014-08-28 |
20140242639 | CONSTRUCTION OF BIFUNCTIONAL SHORT HAIRPIN RNA - A method for designing a bi-shRNA expression cassette encoding a bi-shRNA comprising: selecting one or more target site sequences; providing a backbone sequence comprising a first and a second stem-loop structure, inserting a first passenger strand and a second passenger strand and providing for synthesis of the bi-shRNA expression cassette. | 2014-08-28 |
20140242640 | Methods of Making Nanotechnological and Macromolecular Biomimetic Structures - The present invention is in the fields of nanotechnology and biomimetics. In particular, the present invention relates to the use of modified ribosomes to produce biomimetic structures. These biomimetic structures, also known as directed element polymers, are not produced by traditional industrial means but instead are produced by living systems comprising modified ribosomes. | 2014-08-28 |
20140242641 | METHOD FOR OBTAINING AN OPEN PHOTOTROPHIC CULTURE WITH IMPROVED STORAGE COMPOUND PRODUCTION CAPACITY - The invention is directed to a method for producing an open phototrophic culture with improved storage compound production capability. | 2014-08-28 |
20140242642 | DUAL COFACTOR SPECIFIC RIBITOL DEHYDROGENASE AND USE THEREOF - There are provided a novel ribitol dehydrogenase, a residue determining double coenzyme specificity, and a method for preparing L-ribulose using the same, and more particularly, to a ribitol dehydrogenase producing rare sugars, nucleic acid molecules encoding the same, a vector including the nucleic acid molecules, a transformant including the vector, a mutant of the ribitol dehydrogenase, and a method for preparing L-ribulose using the ribitol dehydrogenase. The ribitol dehydrogenase having double coenzyme specificity, which is derived from | 2014-08-28 |
20140242643 | The Use of Phosphoketolase for Producing Useful Metabolites - The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium. | 2014-08-28 |
20140242644 | PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF - Process for the enzymatic synthesis of the compound of formula (I): | 2014-08-28 |
20140242645 | PROCESS FOR MAKING BETA 3 AGONISTS AND INTERMEDIATES - The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions. | 2014-08-28 |
20140242646 | OXIDATION AND AMINATION OF PRIMARY ALCOHOLS - The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO—(CH | 2014-08-28 |
20140242647 | IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES - The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention. | 2014-08-28 |
20140242648 | PROTEIN HAVING ACTIVITY TO PROMOTE FATTY ACID CHAIN ELONGATION, GENE ENCODING SAME AND USE THEREOF - The present invention relates to a protein having an activity to promote fatty acid chain elongation, a polynucleotide encoding the same, etc. The present invention provides, for example, a polynucleotide containing the nucleotide sequence shown in SEQ ID NO: 1 or 4, a polynucleotide encoding a protein which consists of the amino acid sequence shown in SEQ ID NO: 2, an expression vector and a transformant, each containing such a polynucleotide, a method for preparing lipids or fatty acids by using such a transformant, or a food or the like containing lipids or fatty acids prepared by such a method. | 2014-08-28 |
20140242649 | Hybrid organic-inorganic system for producing biofuels - The present invention provides for a system for converting CO | 2014-08-28 |
20140242650 | Recominant Ralstonia Eutropha Capable of Producing Polyactic and Acid or Polylatic Acid Polymer, and Method for Producing Polyactic Acid or Polylatic Acid Copolymer Using the Same - Provided are a recombinant | 2014-08-28 |
20140242651 | ENZYMATICALLY CATALYZED METHOD OF PREPARING MONO-ACYLATED POLYOLS - The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived from | 2014-08-28 |
20140242652 | METHOD FOR PRODUCING SUCCINIC ACID - A method for producing succinic acid comprising (A) a step of converting an organic raw material to succinic acid in the presence of a microorganism or a processed product thereof in an aqueous medium and (B) a step of recovering the succinic acid, the method being characterized in that (A) the step of converting an organic raw material to succinic acid comprises:
| 2014-08-28 |
20140242653 | METHOD FOR PRODUCING PYRUVIC ACID FROM ALGINIC ACID - A method for producing pyruvic acid from polysaccharide alginic acid that is contained in large amounts in brown algae using the ability to assimilate alginic acid possessed by a lactate-dehydrogenase-gene-deficient | 2014-08-28 |
20140242654 | Butyrate Producing Clostridium species, Clostridium pharus - A clostridia bacterial species | 2014-08-28 |
20140242655 | Bioconversion Process for Producing Nylon-7, Nylon-7, 7 and Polyesters - Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters. | 2014-08-28 |
20140242656 | METHOD FOR PRODUCING ALCOHOLS AND/OR SOLVENTS FROM PAPER PULPS WITH RECYCLING OF THE NON-HYDROLYSATED PLANT MATERIAL IN A REGENERATION REACTOR - This invention describes a process for the production of alcohols and/or solvents from cellulosic or lignocellulosic biomass that comprises at least the following stages:
| 2014-08-28 |
20140242657 | PROCESS FOR THE PRODUCTION OF ALCOHOLS AND/OR SOLVENTS FROM PAPERMAKING PULPS WITH RECYCLING OF NON-HYDROLYZED VEGETATION - This invention describes a process for the production of alcohols and/or solvents from cellulosic or lignocellulosic biomass that comprises at least the following stages:
| 2014-08-28 |
20140242658 | Method for production of isoprenoid compounds - The present invention is directed to variant squalene synthase enzymes, including | 2014-08-28 |
20140242659 | METHOD FOR PRODUCING RENEWABLE FUELS - According to the present invention, organic material is converted to biogas through anaerobic digestion and the biogas is purified to yield a combustible fluid feedstock comprising methane. A fuel production facility utilizes or arranges to utilize combustible fluid feedstock to generate renewable hydrogen that is used to hydrogenate crude oil derived hydrocarbons in a process to make transportation or heating fuel. The renewable hydrogen is combined with crude oil derived hydrocarbons that have been desulfurized under conditions to hydrogenate the liquid hydrocarbon with the renewable hydrogen. The present invention enables a party to receive a renewable fuel credit for the transportation or heating fuel. | 2014-08-28 |
20140242660 | Chimeric isoprenoid synthases and uses thereof - Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide. | 2014-08-28 |
20140242661 | PROCESS CONTROL METHOD - A process control method, the method comprising the steps of: (i) Passing a portion of a biomass containing liquid from a first reactor ( | 2014-08-28 |
20140242662 | Manipulation of Cells on a Droplet Actuator - A method of growing cells on a droplet actuator is provided. The method may include providing a droplet actuator including a cell culture droplet including a cell culture medium and one or more cells; and maintaining the droplet at a temperature suitable for causing the cells to grow in the cell culture medium on the droplet actuator. Related methods, droplet actuators, and systems are also provided. | 2014-08-28 |
20140242663 | MAGNETIC SEPARATION OF ALGAE - Described herein are methods and systems for harvesting, collecting, separating and/or dewatering algae using iron based salts combined with a magnetic field gradient to separate algae from an aqueous solution. | 2014-08-28 |
20140242664 | ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system. | 2014-08-28 |
20140242665 | Phenyl Xanthene Dyes - Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent “bar codes” for polymeric particles used in the multiplexed analysis of analytes. | 2014-08-28 |
20140242666 | VACCINE FOR SHIGELLA - Disclosed are immunogenic conjugates and therapeutic compositions that include such immunogenic conjugates. Also disclosed are methods of treating and/or inhibiting an | 2014-08-28 |
20140242667 | AMYLASE VARIANTS - The present invention relates to variants of a parent α-amylase, which parent α-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least 80% homology with one or more of these amino acid sequences; and/or displays immunological cross-reactivity with an antibody raised against an α-amylase having one of these amino acid sequences; and/or is encoded by a DNA sequence which hybridizes with the same probe as a DNA sequence encoding an α-amylase having one of these amino acid sequences; in which variant:
| 2014-08-28 |
20140242668 | POLYSACCHARIDE LYASES - The present invention relates to a variant of a mature polysaccharide lyase having a beta helix structure, wherein said variant comprises an N- and/or C-terminal truncation and consists essentially of at least 90% of the beta helix structure of the mature polysaccharide lyase. | 2014-08-28 |
20140242669 | PRODUCTION OF INFECTIOUS RNA VIRUSES IN YEAST - The method described herein provides a novel platform utilizing yeast as a biological non-host system to express and assemble whole viruses for use as attenuated or killed vaccines. | 2014-08-28 |
20140242670 | PRODUCTION OF POLIOVIRUS AT HIGH TITERS FOR VACCINE PRODUCTION - Described is a process for producing poliovirus, the process comprising: a) providing a serum-free suspension culture of cells, which are primary human retina (HER) cells that have been immortalized by expression of adenovirus E | 2014-08-28 |
20140242671 | Cell Line for Production of Adeno-associated Virus - This invention relates to a HEK293 cell line that grows under animal component-free suspension conditions. The cell line is ideal for rapid and scalable production of adeno-associated virus (AAV) and supports production of all serotypes and chimera of AAV. | 2014-08-28 |
20140242672 | Lactobacillus Mutant, Nucleotide Sequence for Lactobacillus Mutant and Primers for Nucleotide Sequence of Lactobacillus Mutant - The present invention relates to a lactobacillus mutant, a nucleotide sequence for lactobacillus mutant, and primers for nucleotide sequence of | 2014-08-28 |
20140242673 | CHEMICALLY DEFINED CULTURE MEDIUM FOR FERMENTATION TO PRODUCE SUCCINIC ACID AND APPLICATION THEREOF - This invention belongs to the technical field of industrial microorganism fermentation and relates to a type of chemical defined medium used for succinic acid production by fermentation and its application. The chemical defined medium of this invention used for succinic acid production by fermentation includes conventional compositions and critical growth factor compositions. Said critical growth factor compositions include biotin or 5-ALA, niacin, amino acid, and methionine. This formula determines four critical growth factors of succinic acid fermentation through reasonable technical means. The culture medium is free of complicated and expensive nutritious compositions such as yeast powder and peptone. Reliance on expensive vitamin by production of succinic acid through fermentation in defined medium is avoided, so that production cost of succinic acid can be greatly lowered, and subsequent separation process can be simplified, constituting a key step of industrial production of succinic acid using chemical defined medium. | 2014-08-28 |
20140242674 | PENTOSE FERMENTATION BY A RECOMBINANT MICROORGANISM - The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods. | 2014-08-28 |
20140242675 | Monascus Purpureus Mutant, Nucleotide Sequence for Monascus Purpureus Mutant and Primers for Nucleotide Sequence of Monascus Purpureus Mutant - The present invention relates to a mutant of | 2014-08-28 |
20140242676 | ARTIFICIAL LEAF-LIKE MICROPHOTOBIOREACTOR AND METHODS FOR MAKING THE SAME - Described herein are algae carbon capture systems and biomass production systems, and more specifically, algal based microphotobioreactors (μPBRs) comprising a biocompatible polymer (e.g., hydrogel) containing algae, inorganic carbon, light-frequency shifting agents (e.g., quantum dots and/or dyes of fluorescent proteins) and methods for making such μPBRs. | 2014-08-28 |
20140242677 | PHOTOBIOREACTOR - A method of operating a closed photobioreactor for cultivation of phototrophic microorganisms. The photobioreactor comprises a culture liquid and is partially or completely surrounded by water of a water body. A density difference between the culture liquid and the surrounding water is provided so that the position of the photobioreactor in the water body is controlled. A closed photobioreactor for cultivation of phototrophic microorganisms. The photobioreactor is adapted to comprise a culture liquid and to be partially or completely surrounded by water of a water body. The photobioreactor comprises means for determining the density difference between the culture liquid and the surrounding water. | 2014-08-28 |
20140242678 | APPARATUS AND METHOD FOR A LYSIS OF A SAMPLE, IN PARTICULAR FOR AN AUTOMATED AND/OR CONTROLLED LYSIS OF A SAMPLE - The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc ( | 2014-08-28 |
20140242679 | Method for Producing Hypoallergenic Peanut Products - A peanut food product with reduced levels of allergenic proteins such as Ala h1/h2/h3 is produced by initiating the germination process in raw peanuts, holding the peanuts in moist conditions to initiate germination and then treating with bromelain. | 2014-08-28 |
20140242680 | EMISSIONS CONTROL OF SPENT AIR FROM CUMENE OXIDATION - Methods and systems for removing volatile organic compounds from spent air are provided. The method can include oxidizing cumene in the presence of an oxidant to produce an oxidized product containing methanol and a spent air, separating the spent air from the oxidized product, contacting the spent air with an absorbent, an adsorbent, or a mixture thereof to remove at least a portion of any impurities in the spent air to produce a first purified air, and contacting the first purified air with a biological material to produce a treated air. | 2014-08-28 |
20140242681 | PHOTOBIOREACTOR - A photobioreactor system may include a one or more fluidly connectable tubes for growing or producing microorganisms or biomass such as microalgae. The system may include either a single tube loop or an array of tubes. A first fluid may be held in the tube or tubes, and an inlet port may be provided for introducing a second fluid into the tube or tubes. The tube or tubes may be arranged vertically so that the second fluid rises through the tube or tubes. An outlet port may be provided at the top of the tube or tubes to remove the second fluid. The second fluid may be recirculated through the system via inlet and outlet lines as well as a pump and a replaceable reservoir for holding the second fluid. Where there is an array of tubes, a single inlet and outlet line may be sued for each tube. | 2014-08-28 |
20140242682 | Salivary Diagnostic Systems - Salivary diagnostic systems are provided for improved disease diagnosis and overall health care. Salivary diagnostic systems are provided for the plurality of steps required in salivary diagnostic processes. The salivary diagnostic systems are interchangeably coupled by various methods and steps and include a collection system, a filter system, an evaluation system, and a reporting system. One or more salivary diagnostic systems are comprised in at least one salivary diagnostic device. Salivary diagnostic devices include a toothbrush, an implement, and a stand-alone system. The systems provide for the collection, filtration, and evaluation of saliva samples and the reporting of diagnostic data derived from the evaluation of saliva samples. | 2014-08-28 |
20140242683 | APPARATUS FOR SELECTIVE EXCITATION OF MICROPARTICLES - Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an interference pattern generation module that splits a first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams. | 2014-08-28 |
20140242684 | SYSTEM FOR HYDROLYZING A CELLULOSIC FEEDSTOCK SLURRY USING ONE OR MORE UNMIXED AND MIXED REACTORS - Provided is a system for hydrolyzing a cellulosic feedstock slurry. The system comprises one or more unmixed reactors for receiving and partially hydrolyzing the cellulosic feedstock slurry so as to produce a mixture of partially hydrolyzed slurry. The unmixed reactors may be plug flow reactors. One or more mixed reactors are downstream of the unmixed reactors for continuing the hydrolysis of the mixture of the partially hydrolyzed slurry. The one or more unmixed and mixed reactors may be connected in series, parallel or a combination thereof. | 2014-08-28 |
20140242685 | INLET VALVE FOR CHAMBER SYSTEMS AND SAMPLE CONTAINERS, AND CHAMBER SYSTEMS AND SAMPLE CONTAINERS WITH SUCH INLET VALVES - An inlet valve charges an inner chamber of a system or sample container with liquid and has a first pipetting axis, an inlet opening, it supplies liquid by a laboratory pipette that is automatically reclosed and also has a valve body with a blocking element, a pressing part and a throat, a valve space enclosing the valve body at least partly near the throat, a spring mechanism and a sealing element. The throat connects the blocking element to the pressing part and has an open passage region which opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body can be brought to an open position by pressing the pressing part against the spring mechanism. | 2014-08-28 |
20140242686 | TRASH COMPOSTING APPARATUS - A system for decomposing materials includes a main container and a drum container housed within the main container. The drum container includes a central longitudinal axis about which the drum container rotates. The drum container also includes at least one partition extending transverse to the central longitudinal axis of the drum container dividing the drum container into a first compartment and a second compartment. The partition includes a central aperture in alignment with the central longitudinal axis allowing for the passage of decomposing material between the first compartment and the second compartment as decomposing material rises to a level exceeding the distance from an outer wall of the drum container thereof to a circumferential edge of the central aperture. A venting pipe radially extends within the drum container. | 2014-08-28 |
20140242687 | PHOTOBIOREACTOR - A photobioreactor system may include a one or more fluidly connectable tubes for growing or producing microorganisms or biomass such as microalgae. The system may include either a single tube loop or an array of tubes. A first fluid may be held in the tube or tubes, and an inlet port may be provided for introducing a second fluid into the tube or tubes. The tube or tubes may be arranged vertically so that the second fluid rises through the tube or tubes. An outlet port may be provided at the top of the tube or tubes to remove the second fluid. The second fluid may be recirculated through the system via inlet and outlet lines as well as a pump and a replaceable reservoir for holding the second fluid. Where there is an array of tubes, a single inlet and outlet line may be sued for each tube. | 2014-08-28 |
20140242688 | PHOTOBIOREACTOR - Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of the cultivation support. Devices for the large scale and continuous cultivation of photosynthetic microorganisms incorporating photobioreactors and methods of use are disclosed. Also disclosed are methods of producing fermentable sugar from photosynthetic microorganisms using a photobioreactor of the invention. | 2014-08-28 |
20140242689 | VORTEX BIOREACTOR - The invention relates biotechnology. The vortex bioreactor comprises a cylindrical tank with a lid, a device for agitating a medium, said device being located in the tank and consisting of a bladed wheel secured horizontally on a vertical shaft in the upper portion of the tank and a horizontal annular baffle mounted in the tank with a gap relative to the cylindrical walls of the tank and having a central axial orifice. The horizontal annular baffle is situated on a vertical rod that is capable of rotating. A mechanism for adjusting the position of the horizontal annular baffle on the rod is disposed on the vertical rod. A tube or telescopic tube is disposed inside the cylindrical tank and is joined to the axial orifice of the horizontal annular baffle. Said tube is affixed to the baffle from below and is disposed around the rod. The top surface of the horizontal annular baffle is provided with radial channels that are positioned from the axial orifice to the edge of the annular baffle with a downwards incline toward the bottom of the cylindrical tank. | 2014-08-28 |
20140242690 | CYSTIC FIBROSIS TREATMENT - The present invention relates to medicaments for the treatment of cystic fibrosis. Also provided are methods of preparing such medicaments so that they can be used in a treatment regime for cystic fibrosis. The present invention also provides a kit of parts including the medicament of the invention, as well as treatment regimes for cystic fibrosis. | 2014-08-28 |
20140242691 | Neural Progenitor Cell Populations - This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. The differentiated cell populations or the neural progenitors can be generated in large quantities for use in drug screening and the treatment of neurological disorders. | 2014-08-28 |
20140242692 | MAMMALIAN GENES INVOLVED IN TOXICITY AND INFECTION - The present invention relates to cellular proteins that are involved in toxicity and infection or are otherwise associated with the life cycle of one or more pathogens. | 2014-08-28 |
20140242693 | Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells - The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. | 2014-08-28 |
20140242694 | COMPOSITION CONTAINING COMPLEX CYTOKINES DERIVED FROM EBV-INFECTED B CELLS FOR INDUCING THE MATURATION OF DENDRITIC CELLS - A composition for deriving the maturation of dendritic cells includes complex cytokines generated by the simulation, the expression of which is induced on EBV-infected B cells. The dendritic cell maturation process, which conventionally takes approximately 7 days, can be shortened to 2 days, thereby producing dendritic cells in a more economically advantageous and effective manner. | 2014-08-28 |
20140242695 | PROTEIN-INDUCED PLURIPOTENT CELL TECHNOLOGY AND USES THEREOF - A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof. | 2014-08-28 |
20140242696 | Thermally Induced Gelation Of Collagen Hydrogel And Method Of Thermally Inducing Gelling A Collagen Hydrogel - The present invention relates to collagen hydrogels. Particularly, the invention relates to hydrogels comprising a telopeptide collagen (“telo-collagen”) and an atelopeptide collagen (“atelo-collagen”); hydrogels comprising collagen and chitosan; methods of making the hydrogels; methods of reducing gelation of a hydrogel mixture at room temperature; methods of reducing compaction of cells; and methods of culturing cells on such hydrogels. | 2014-08-28 |
20140242697 | Thermally Induced Gelation Of Collagen Hydrogel And Method Of Thermally Inducing Gelling A Collagen Hydrogel - The present invention relates to collagen hydrogels. Particularly, the invention relates to hydrogels comprising a telopeptide collagen (“telo-collagen”) and an atelopeptide collagen (“atelo-collagen”); hydrogels comprising collagen and chitosan; methods of making the hydrogels; methods of reducing gelation of a hydrogel mixture at room temperature; methods of reducing compaction of cells; and methods of culturing cells on such hydrogels. | 2014-08-28 |
20140242698 | MEDICAL RECORDS STORAGE SYSTEM - Electronic medical records have to evolve from the isolated hospital systems or insurance company owned storage data silos based on a binary code accessed by patients through portals to the patient themselves becoming the data silo with portals to which all hospital systems or insurance companies send data for storage and future access. Transfer processes for binary or non-binary data systems facilitate data into patient centered servers, which combine source of origination codes. Combining the patient specific genome sequence with binary data generates a 3D data set which has more information than each data set alone. The patient's binary code represents the externally expressed DNA sequence. From this combination, future medical events can be predicted. Also, the system enables bidirectional data transfer so that health systems no longer need to maintain expensive data silos which are incomplete. | 2014-08-28 |