35th week of 2015 patent applcation highlights part 21 |
Patent application number | Title | Published |
20150239794 | IGNITION COMPOSITIONS, AND PREPARATIONS AND USES THEREOF - An ignition composition comprising a low electron affinity material, an oxidizer and a binder. The ignition composition may be made by A1) preparing a coagulation composition by a shock-gel process using the ingredients of the ignition composition disclosed herein, which comprises: A1-a) dissolving the binder in a low-boiling-point polar solvent to provide a binder solution; A1-b) mixing the low electron affinity material and the oxidizer with the binder solution; and A1-c) adding a low-boiling-point non-polar solvent to the mixture provided by step I-b) to precipitate the binder and form the coagulation composition; and A2) converting the coagulation composition into granular composition using a suitable method. | 2015-08-27 |
20150239795 | Fluid Activated Disintegrating Metal System - An engineered composite system designed to be passive or inert under one set of conditions, but becomes active when exposed to a second set of conditions. This system can include a dissolving or disintegrating core, and a surface coating that has higher strength or which only dissolves under certain temperature and pH conditions, or in selected fluids. These reactive materials are useful for oil and gas completions and well stimulation processes, enhanced oil and gas recovery operations, as well as in defensive and mining applications requiring high energy density and good mechanical properties, but which can be stored and used for long periods of time without degradation. | 2015-08-27 |
20150239796 | ONE POT SYNTHESIS OF 18F LABELEDTRIFLUOROMETHYLATED COMPOUNDS WITH DIFLUORO(IODO)METHANE - The present invention relates to compositions and methods for the synthesis of | 2015-08-27 |
20150239797 | POLYMER PRECURSORS OF RADIOLABELED COMPOUNDS, AND METHODS OF MAKING AND USING THE SAME - One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a method of synthesizing radiolabeled compounds. | 2015-08-27 |
20150239798 | PROCESS FOR MAKING RENEWABLE SURFACTANT INTERMEDIATES AND SURFACTANTS FROM FATS AND OILS AND PRODUCTS THEREOF - The present invention relates generally to methods for producing renewable detergent compounds. More specifically, the invention relates to methods for producing detergent intermediates, including bio-linear alkylbenzene (LAB), bio-alcohols, and long chain bio-paraffins, from natural oils. | 2015-08-27 |
20150239799 | PROCESS AND CATALYST FOR CONVERSION OF ACETIC ACID TO ISOBUTENE - A process is disclosed for converting acetic acid to isobutene in the presence of a catalyst. In certain embodiments, a Zn | 2015-08-27 |
20150239800 | PROCESS AND CATALYST FOR CONVERSION OF ACETIC ACID TO ISOBUTENE AND PROPYLENE - A process is disclosed for converting acetic acid to propylene and isobutene as the principal hydrocarbon products made, in the presence of a catalyst and in the further presence of hydrogen. In certain embodiments, a Zn | 2015-08-27 |
20150239801 | Process to Make Propylene from Isobutanol by Dehydration and Subsequent Cracking - A process for conversion of isobutanol to make propylene includes dehydrating isobutanol to produce butenes. The process includes cracking the butenes to produce propylene. | 2015-08-27 |
20150239802 | HIGH TEMPERATURE REFORMING PROCESS AND CATALYST FOR USE THEREIN - A process for generating aromatics from a hydrocarbon feedstream is disclosed. The process includes the steps of (a) passing the hydrocarbon feedstream to a reformer, wherein the reformer is operated at a temperature greater than 540° C.; and (b) reforming the hydrocarbon feedstream to aromatics in the presence of a catalyst, wherein the catalyst comprises (i) a refractory inorganic oxide support, (ii) a platinum group metal, (iii) a Group IVA metal, (iv) a third metal selected from alkali metals and alkaline earth metals, and (v) a halogen. | 2015-08-27 |
20150239803 | PROCESS FOR MAKING BIOBASED ISOPRENE - Processes are described for making biobased isoprene, wherein a biobased isobutene prepared from acetic acid in the presence of a catalyst is combined with a formaldehyde source to form a reaction mixture, and the reaction mixture is reacted to yield biobased isoprene. In certain embodiments, methyl-tert-butyl ether prepared by reacting the same biobased isobutene with methanol serves as a formaldehyde source, being oxidatively cracked to produce formaldehyde as well as isobutene for being converted to the biobased isoprene. | 2015-08-27 |
20150239804 | PROCESS FOR XYLENES PRODUCTION - Provided is a process for producing aromatics including the steps of preparing a C | 2015-08-27 |
20150239805 | Offgas Stream Direct Contact Condenser - Methods and systems for the dehydrogenation of hydrocarbons include a direct contact condenser to remove compounds from an offgas process stream. The reduction of compounds can decrease duty on the offgas compressor by removing steam and aromatics from the offgas. The dehydrogenation reaction system can be applicable for reactions such as the dehydrogenation of ethylbenzene to produce styrene, the dehydrogenation of isoamiline to produce isoprene, or the dehydrogenation of n-pentene to produce piperylene. | 2015-08-27 |
20150239806 | POLYMERIZABLE SPIROBISINDANE MONOMERS AND POLYMERS PREPARED THEREFROM - Monomers and polymerizable compositions that can be polymerized using a free-radical polymerization reaction are provided. The monomers have two vinyl groups as well as a spirobisindane-type structure. Polymers prepared from the polymerizable compositions are also provided. The polymers can be porous. | 2015-08-27 |
20150239807 | PROCESS FOR THE PRODUCTION OF CHLORINATED PROPENES - Processes for the production of chlorinated propenes are provided. The present processes make use of 1,2-dichloropropane, a by-product in the production of chlorohydrin, as a low cost starting material, alone or in combination with 1,2,3-trichloropropane. At least one chlorination step is conducted in the gas phase. The present processes can also generate anhydrous HCI as a byproduct that can be removed from the process and used as a feedstock for other processes, providing further time and cost savings. | 2015-08-27 |
20150239808 | Process for the Preparation of Fluoroolefin Compounds - The subject of the invention is a process for the preparation of fluoroolefin compounds. It relates more particularly to a process for manufacturing a (hydro)fluoroolefin compound comprising (i) bringing at least one compound comprising from three to six carbon atoms, at least two fluorine atoms and at least one hydrogen atom, provided that at least one hydrogen atom and one fluorine atom are located on adjacent carbon atoms, into contact with potassium hydroxide in a stirred reactor, containing an aqueous reaction medium, equipped with at least one inlet for the reactants and with at least one outlet, in order to give the (hydro)fluoroolefin compound, which is separated from the reaction medium in gaseous form, and potassium fluoride, (ii) bringing the potassium fluoride formed in (i) into contact, in an aqueous medium, with calcium hydroxide in order to give potassium hydroxide and to precipitate calcium fluoride, (iii) separation of the calcium fluoride precipitated in step (ii) from the reaction medium and (iv) optionally, the reaction medium is recycled after optional adjustment of the potassium hydroxide concentration to step (i). | 2015-08-27 |
20150239809 | Method for the Production of Neopentyl Glycol - A method for preparing neopentyl glycol by addition of isobutyraldehyde and formaldehyde in the presence of a tertiary alkylamine as catalyst to give hydroxypivalaldehyde with subsequent hydrogenation at a temperature of 80 to 140° C. and at a pressure of 2 to 18 MPa in the liquid phase, is characterized in that the hydrogenation is carried out in the presence of a copper chromite catalyst comprising the activators barium and manganese. | 2015-08-27 |
20150239810 | REMOVAL OF NITROGEN-CONTAINING IMPURITIES FROM ALCOHOL COMPOSITIONS - A process for the treatment of an alcohol composition comprising nitrogen-containing contaminants, the process comprising contacting the alcohol composition in the vapour phase with an absorbent in an adsorption zone. | 2015-08-27 |
20150239811 | Process for Producing High-Yield Biodiesel Applying High Acidity Triglycerides With Generation of Glycerin 90% Free of Salts - A process is provided for producing high-yield biodiesel applying high acidity triglycerides with generation of glycerin 90% free of salts starting from fatty lower cost fatty material allied with an esterification and innovative extraction process that generates a further value, more specifically for the production of biodiesel. | 2015-08-27 |
20150239812 | PROCESS FOR MAKING BIOBASED FUEL ADDITIVES - Wholly biobased MTBE and ETBE fuel additive materials are described, together with fuel compositions including such additives and processes for making the wholly biobased MTBE and ETBE using isobutene prepared from acetic acid in the presence of a Zn | 2015-08-27 |
20150239813 | Process for production of DME from crude methanol - The invention provides a process for the production of purified dimethylether (DME). Methanol is dehydrated to provide a first DME-containing product. The first DME-containing product is purified in a two-stage process. The invention also provides an apparatus arranged to carry out said process. | 2015-08-27 |
20150239814 | PROCESS FOR PHOTOCATALYTIC ACCEPTOR-FREE DEHYDROGENATION OF ALKANES AND ALCOHOLS - A process for photocatalytic acceptor-free dehydrogenation of alkanes and alcohols, in which an alkane or an alcohol is irradiated in the presence of a rhodium complex containing organic phosphorus(III) compounds as ligands as a catalyst, and in the presence of at least one Lewis base is provided. | 2015-08-27 |
20150239815 | METHOD FOR PREPARING ACROLEIN FROM GLYCEROL - The disclosure concerns a method for preparing acrolein from glycerol, according to which a dehydration of the glycerol is carried out in the presence of a catalyst MWOA, wherein MWO represents a mixture of simple oxides and/or mixed oxides of tungsten and at least one metal M selected among zirconium, silicon, titanium, aluminium and yttrium, and A represents one or several Lewis base(s), one said Lewis base being of the formula B(R1)p(R2)q(R3)r, wherein B is an element selected among C, S, P, O, N and halides, R1, R2 and R3 represent, independently of each other, H, a C1-C6 alkyl group, O, OH or OR wherein R represents a C1-C6 alkyl group, and the sum of p, q and r varies from 0 to 4. | 2015-08-27 |
20150239816 | METHOD FOR PREPARATION OF 2-(2,3-DIMETHYLPHENYL)-1-PROPANAL WITH CHLOROACETONE - The invention discloses a method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal starting from 1-bromo 2,3-dimethylbenzene and chloroacetone, its use in perfumes and its use for the preparation of medetomidine. | 2015-08-27 |
20150239817 | PROCESS FOR THE MANUFACTURE OF ALKENONES - A process for the manufacture of an alkenone comprising the steps of: (a) providing a halogenated precursor of the alkenone and (b) subjecting at least a fraction of the halogenated precursor of step (a) to a thermolysis reaction to form a reaction mixture comprising the alkenone and a hydrogen halide wherein the hydrogen halide is removed from the reaction mixture by cyclonic separation is described. | 2015-08-27 |
20150239818 | TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS WITH REDOX-ACTIVE THERAPEUTICS - Methods of treating or suppressing pervasive developmental disorders (PDDs) including; autistic disorder, Asperger's syndrome, childhood disintegrative disorder (CDD), Rett's disorder, and PDD-not otherwise specified (PDD-NOS) or attention deficit/hyperactivity disorder (ADHD) comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds as disclosed herein. | 2015-08-27 |
20150239819 | METHOD FOR MANUFACTURING METAL PRECURSOR AND METHOD FOR MANUFACTURING METAL INK BY USING METAL PRECURSOR - A method of preparing a metal precursor and a method of preparing a metal ink using the same are provided. The method of preparing a metal precursor and the method of preparing a metal ink using the same can be useful in facilitating separation and purification of a precursor from impurities formed during precursor synthesis by allowing a metal precursor to form a suboligomeric aggregate as the metal precursor is synthesized using a fatty acid having a substituent at an α position, and also enhancing solubility, enabling low-temperature sintering and improving coating film physical properties and electrical properties of the final metal ink. | 2015-08-27 |
20150239820 | System and Method for Separating Lipid Based Products from Biomass - Methods and systems for the production and isolation of fatty acid methyl esters (FAMEs) from a lipid source are described. The method includes extracting a lipid from a lipid source and transesterifying the lipid into a FAME. The method may also include fractionating the FAME from the system. A method of selectively transesterifying a lipid into a FAME is also described. | 2015-08-27 |
20150239821 | PROCESS FOR HYDROGENATION OF OLEFINIC OR ACETYLENIC BONDS - The present invention relates to a process for hydrogenation of olefinic or acetylenic bonds. Further, the present invention relates to a process for selective hydrogenation of olefinic or acetylenic bonds and/including triglycerides using modified metal supported on solid acidic metal oxide catalyst and the process for the preparation thereof. The present invention provides a process for hydrogenation of olefinic or acetylenic bonds using metal supported on solid acid metal oxide based catalyst, at moderate conditions. The present invention also relates to the preparation of metal supported on solid acid metal oxide based catalyst for hydrogenation reactions under mild conditions. | 2015-08-27 |
20150239822 | LIQUID 1,3/1,4-ALKOXYLATED CYCLOHEXANEDIMETHANOL BASED DIACRYLATES - Disclosed herein are compounds of formula (I): wherein n, R | 2015-08-27 |
20150239823 | ALICYCLIC DICARBOXYLIC ACID ESTER COMPOUND AND MANUFACTURING METHOD THEREOF - The alicyclic dicarboxylic acid ester compound of the present invention is represented by the following formula (1): | 2015-08-27 |
20150239824 | BRANCHED OR MACROCYCLIC POLYAMINES AND USES THEREOF - The present invention relates to synthetic polyamines and their polyammonium derivatives and their use as a pharmacological or biological research tool or as a therapeutic agent. | 2015-08-27 |
20150239825 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 2015-08-27 |
20150239826 | CARBON-BASED FLUORESCENT TRACERS AS OIL RESERVOIR NANO-AGENTS - The present invention relates to carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs. The carbon-based fluorescent nano-agents may be used in the analysis of the porosity of a formation. The nanoagents are suitable for injection into a petroleum reservoir and may be recovered from the reservoir for the determination of hydrocarbon flow rates and retention times. | 2015-08-27 |
20150239827 | ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS - The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. (Formula I) | 2015-08-27 |
20150239828 | METHODS AND SYSTEMS FOR PURIFYING AN ACETONITRILE WASTE STREAM AND METHODS FOR SYNTHESIZING OLIGONUCLEOTIDES USING PURIFIED ACETONITRILE WASTE STREAMS - Methods and systems for purifying an acetonitrile waste stream and methods for synthesizing an oligonucleotide using a purified acetonitrile waste stream are provided. An exemplary method for purifying an acetonitrile waste stream includes providing an acetonitrile waste stream and fractionating the acetonitrile waste stream to produce a single overhead fraction. The method includes condensing the single overhead fraction to produce a condensed single overhead fraction and contacting the condensed single overhead fraction with an adsorbent to produce an acetonitrile stream that comprises an amount of at least one impurity that is reduced relative to the acetonitrile waste stream. | 2015-08-27 |
20150239829 | SULFONAMIDE AND SULFINAMIDE PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES - The present invention provides compounds and pharmaceutical compositions for treating neurological diseases such as multiple sclerosis. | 2015-08-27 |
20150239830 | CLASS II HMG-COA REDUCTASE INHIBITORS AND METHODS OF USE - Disclosed are compositions and methods for treating bacterial infections. | 2015-08-27 |
20150239831 | INHIBITORS OF CENTRAL NERVOUS SYSTEM VASOACTIVE INHIBITORY PEPTIDE RECEPTOR 2 - The present invention relates to compounds that inhibit VIPR | 2015-08-27 |
20150239832 | ANALOGS AND PRODRUGS OF LOOP DIURETICS, INCLUDING BUMETANIDE, FUROSEMIDE AND PIRETANIDE; COMPOSITIONS AND METHODS OF USE - Novel analogs and prodrugs of the loop diuretics bumetanide, furosemide and piretanide are described. Pharmaceutical compositions containing loop diuretic analogs and prodrugs are also described. These analogs and prodrugs are particularly useful for the treatment and/or prophylaxis of conditions that involve the NKCC cotransporter family (NKCC1 and NKCC2), or the KCC cotransporter family (KCC1, KCC2, KCC3, KCC4), or GABAa receptors. Such conditions include, but are not limited to anxiety disorders, epilepsy, migraine, non-epileptic seizures, sleep disorders, obesity, eating disorders, autism, depression, edema, glaucoma, stroke, ischemia, neuropathic pain, addictive disorders, schizophrenia, psychosis, and tinnitus. | 2015-08-27 |
20150239833 | COMPOSITION, SYNTHESIS, AND USE OF NEW ARYLSULFONYL ISONITRILES - This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions. | 2015-08-27 |
20150239834 | SYMMETRIC IONIZABLE CATIONIC LIPID FOR RNA DELIVERY - What are described are compounds of formulas II, III, and IV. The compound of formula II | 2015-08-27 |
20150239835 | COMPOSITION, SYNTHESIS, AND USE OF A NEW CLASS OF ISONITRILES - This invention relates to novel isonitriles, including arylthio isonitriles, and methods for their preparation. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions. | 2015-08-27 |
20150239836 | ALKOXY COMPOUNDS FOR DISEASE TREATMENT - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. | 2015-08-27 |
20150239837 | Factor D Inhibitors Useful for Treating Inflammatory Disorders - Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer. | 2015-08-27 |
20150239838 | Compounds for Treatment of Complement Mediated Disorders - Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer. | 2015-08-27 |
20150239839 | PROCESS FOR PHOTOCATALYTIC ACCEPTOR-FREE DEHYDROGENATION OF HYDROCARBAZOLES AND HYDROINDOLES - A process for the photocatalytic acceptor-free dehydrogenation of hydrocarbazoles and hydroindoles is provided, wherein a hydrocarbazole or hydroindole is irradiated in the presence of a catalyst that is a rhodium complex containing organic phosphorus(III) compounds as ligands. | 2015-08-27 |
20150239840 | COMPOUNDS USEFUL FOR PRODUCING AN OPTICALLY ACTIVE DIAZABICYCLOOCTANE COMPOUND - A compound of the following compound (B): | 2015-08-27 |
20150239841 | PROCESS AND CATALYST FOR THE PRODUCTION OF PYRIDINE AND ALKYL DERIVATIVES THEREOF - A process for increasing the overall yield of pyridine or its alkyl pyridine derivatives during a base synthesis reaction is disclosed. The process comprises reacting a C | 2015-08-27 |
20150239842 | BENZAMIDE AND HETEROBENZAMIDE COMPOUNDS - This invention relates to compounds of general formula (I), in which R | 2015-08-27 |
20150239843 | METHODS OF ISOLATING (4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYL)BORONATES AND METHODS OF USING THE SAME - Methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate include adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas or carbon dioxide solid (dry ice) and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid. The precipitated solid may be removed from the mixture. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronates to produce methyl-4-amino-3-chloro-6-(4-chloro-2-fluoro-3-substituted-phenyl)pyridine-2-carboxylates are also disclosed. A 4-chloro-2-fluoro-3-substituted-phenylboronate produced by one of the methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate is also disclosed, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronate may be obtained at a yield of greater than or equal to about 90%. | 2015-08-27 |
20150239844 | QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS - The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. For example, the compounds of the present invention are useful in the treatment of metabolic disorders. | 2015-08-27 |
20150239845 | QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS - The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. For example, the compounds of the present invention are useful in the treatment of metabolic disorders. | 2015-08-27 |
20150239846 | METHOD FOR THE PREPARATION OF PERFLUOROALKYL CONTAINING PYRAZOLES CARBOXYLATES - The present invention pertains to a novel process for the preparation of Fluoroalkylpyrazole- or Bisperfluoroalkypyrazole carboxylates comprising a cyclization of Perfluoroalkyl ketoesters with hydrazines. | 2015-08-27 |
20150239847 | HETEROCYCLIC COMPOUNDS AS PESTICIDES - The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel heterocyclic compounds, to processes for their preparation and to intermediates for preparing the heterocyclic compounds. | 2015-08-27 |
20150239848 | ENZALUTAMIDE POLYMORPHIC FORMS AND ITS PREPARATION - The present application relates to crystalline and amorphous forms of Enzalutamide. The present application further relates to amorphous solid dispersions of Enzalutamide with pharmaceutically acceptable carriers. The present application also relates to a process for the preparation of Form R1 of Enzalutamide. | 2015-08-27 |
20150239849 | INHIBITORS OF BETA-SECRETASE - The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | 2015-08-27 |
20150239850 | QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS - Compounds of the formula I | 2015-08-27 |
20150239851 | ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS - Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: R | 2015-08-27 |
20150239852 | PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE - The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme. | 2015-08-27 |
20150239853 | METHOD FOR PRODUCING BIARYL COMPOUND - The invention provides a production method of a biaryl compound of the formula [3] or a salt thereof, including reacting a 2-phenylazole derivative of the formula [1] or a salt thereof, with a benzene derivative of the formula [2] or a salt thereof in the presence of a metal catalyst, a base, and one or more of (a) a monocarboxylic acid metal salt, (b) a dicarboxylic acid metal salt, (c) a sulfonic acid metal salt, and (d) a phosphate or phosphoric amide metal salt represented by R | 2015-08-27 |
20150239854 | DEPROTECTION METHOD FOR TETRAZOLE COMPOUND - The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers. | 2015-08-27 |
20150239855 | Method for Producing Oxazole Compound - An object of the present invention is to provide a novel method for producing an oxazole compound. The invention relates to a method for producing a compound represented by formula (1): wherein R | 2015-08-27 |
20150239856 | 4-(5-Amino-6-Hydroxybenzoxazol-2-YL) Ammonium Benzoate and Preparation Method and Use Thereof - Disclosed in the present invention are 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate shown in formula (I) and the preparation method and use thereof. The preparation method comprises: fully reacting 4-(5-amino-6-hydroxybenzoxazol-2-yl)benzoic acid shown in formula (II) or 4-(5-amino-6-hydroxybenzoxazol-2-yl)carboxamide benzoate, as a raw material, with ammonia in an aqueous solvent, and directly heating the obtained reaction liquid to remove excess ammonia, so as to obtain 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate. The mass of the 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate (ABAA) prepared in the present invention can reach a polymer grade (where the purity is above 99.5%, the content of metal ions is below 200 ppm, and containing no DMF polymerization inhibition impurities), and the 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate can be used as an AB type monomer for preparing PBO and modified PBO fibres, the resulting PBO having an intrinsic viscosity n of up to 38/dl/g, and the method has such features as ABAA being highly soluble in PPA, a fast polymerization speed, a short time of 2-4 h, a low temperature of 150° C., a high molecular weight of the polymer, fibres of excellent tensile property, being easy to industrialize, etc. | 2015-08-27 |
20150239857 | (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS - The present invention relates to (thio)morpholine derivatives of the formula (I), wherein R1 is selected from cyano, (2-4C)alkynyl, (1-4C)alkyl, (3-6C)cycloalkyl, (4-6C)cycloalkenyl, (6-8C)bicycloalkyl, (8-10C)bicyclic group, each optionally substituted with (1-4C)alkyl, phenyl, biphenyl, naphthyl, each optionally substituted with one or more substituents independently selected from halogen, (1-4C)alkyl optionally substituted with one or more fluoro atoms, (2-4C)alkynyl, (1-4C)alkoxy optionally substituted with one or more fluoro atoms, amino, di(1-4C)alkylamino, —SO | 2015-08-27 |
20150239858 | METHOD FOR PRODUCING GLYCIDOL BY SUCCESSIVE CATALYTIC REACTIONS - Disclosed is a method for producing glycidol by successive catalytic reactions. The method includes a series of reactions for the preparation of glycerol carbonate from glycerol and the decarboxylation of the glycerol carbonate. Specifically, the method includes i) reacting glycerol with a dialkyl carbonate to prepare glycerol carbonate, and ii) subjecting the glycerol carbonate to decarboxylation wherein a base is added as a catalyst in step i) and is allowed to react with an acid to form a metal salt after step i), and the salt is used as a catalyst in step ii). According to the method, inexpensive and easy-to-purchase acid and base catalysts can be used to produce glycidol from glycerol, a by-product of biodiesel production, as a starting material in high yield with high selectivity in a convenient, simple, and environmentally friendly way. In addition, the method eliminates the need to separate the base catalyst. | 2015-08-27 |
20150239859 | PERIPHERALLY-ACTING CANNABINOID RECEPTOR AGONISTS FOR CHRONIC PAIN - Peripherally acting cannabinoid agonist compounds, pharmaceutical compositions, and methods of using them are presented. | 2015-08-27 |
20150239860 | PROCESS FOR PREPARING MORPHINE COMPOUNDS - The present application relates to processes for the preparation of morphine compounds utilizing a novel intramolecular [4+2] cycloaddition reaction. | 2015-08-27 |
20150239861 | CONDENSATION PRODUCT OF THEANINE DERIVATIVE AND CARBOXYLIC ACID COUMARIN DERIVATIVE, ITS INTERMEDIATE, PREPARATION METHOD AND USE THEREOF - The present invention relates to a compound as represented by formula (I), which is a condensation product of a theanine derivative and a carboxylic acid coumarin derivative, compounds as represented by formula (II) and formula (III), both of which are intermediates of the condensation product, a method for preparing these compounds, a pharmaceutical composition comprising the compounds, and a use thereof in preparing a medicament for prevention and treatment of tumors, inflammation, cardiovascular diseases, immune deficiency diseases and the like. | 2015-08-27 |
20150239862 | PROCESS FOR THE PREPARATION OF VILANTEROL AND INTERMEDIATES THEREOF - An improved process for the preparation of vilanterol and pharmaceutically acceptable salts thereof is disclosed. More specifically the improved process for preparing intermediates for the preparation of vilanterol is disclosed. | 2015-08-27 |
20150239863 | METHOD FOR PRODUCING LACTIDE DIRECTLY FROM LACTIC ACID AND A CATALYST USED THEREIN - The present invention provides a method for directly producing lactide by subjecting lactic acid to a dehydration reaction in the presence of a catalyst comprising a tin compound, preferably, a tin (IV) compound, wherein lactide can be produced directly or by one step from lactic acid, without going through the step of producing or separating lactic acid oligomer. The method of the present invention has advantages of causing no loss of lactic acid, having a high conversion ratio to lactic acid and a high selectivity to optically pure lactide, and maintaining a long life time of the catalyst. Further, since lactic acid oligomer is not or hardly generated and the selectivity of meso-lactide is low, the method also has an advantage that the cost for removing or purifying this can be saved. | 2015-08-27 |
20150239864 | 3H-1,2-DITHIOCYCLOPENTENE-3-THIOKETONE COMPOUNDS AND APPLICATION THEREOF - The present invention relates to the field of medicaments, and in particular relates to 3H-1,2-dithiocyclopentene-3-thione compounds and application thereof. 3H-1,2-dithiocyclopentene-3-thione compounds disclosed by the invention have new structures shown in formula I or formula II. Proved by experiments, 3H-1,2-dithiocyclopentene-3-thione compounds can directly protect neurons in a cellular model, and can significantly restrain excessive inflammatory responses of brain inflammatory cells; and by using 3H-1,2-dithiocyclopentene-3-thione, focal ischemic cerebral infarct volumes of mice can be remarkably reduced in an animal model. Therefore, the invention provides the application of 3H-1,2-dithiocyclopentene-3-thione compounds and pharmaceutically acceptable salts thereof in the preparation of medicaments for preventing or treating cerebral apoplexy diseases. | 2015-08-27 |
20150239865 | QUINOLONE COMPOUND - The present invention provides a compound represented by the formula (I) | 2015-08-27 |
20150239866 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS - Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer. | 2015-08-27 |
20150239867 | Process for the Preparation of Voriconazole and Analogues Thereof - The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein, by reacting a compound of formula: (Formula XIII) (XIII) with a compound of formula: (Formula XIV and XV) (XIV) (XV) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates. | 2015-08-27 |
20150239868 | Alkyne Compounds for Treatment of Complement Mediated Disorders - Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R | 2015-08-27 |
20150239869 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HDAC6 SELECTIVE INHIBITORS - The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the treatment of various diseases, disorders, or conditions related to HDAC6. | 2015-08-27 |
20150239870 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS - The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds. | 2015-08-27 |
20150239871 | PROCESS FOR THE PREPARATION OF VILAZODONE HYDROCHLORIDE AND ITS AMORPHOUS FORM - The present invention relates to an improved process for the preparation of vilazodone hydrochloride and a process for preparation of novel pure amorphous form of vilazodone hydrochloride. | 2015-08-27 |
20150239872 | ALKYLPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES - This invention relates to alkylpyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy. | 2015-08-27 |
20150239873 | SUBSTITUTED CARBAMATE COMPOUNDS - The invention is concerned with the compounds of formula (I): | 2015-08-27 |
20150239874 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 2015-08-27 |
20150239875 | SUBSTITUTED PYRIDONES AND PYRAZINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY - Substituted 2-pyridones and pyrazinones of formula 1 | 2015-08-27 |
20150239876 | SALTS OF HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE - The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases. | 2015-08-27 |
20150239877 | CRYSTALLINE FORMS OF DIHYDROPYRIMIDINE DERIVATIVES - The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed herein, which may be used for preventing, managing, treating or lessening the severity of a viral disease in a patient, especially hepatitis B infection or a disease caused by hepatitis B infection. | 2015-08-27 |
20150239878 | Novel Compounds for Imaging Tau Proteins That Accumulate In Brain - The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. | 2015-08-27 |
20150239879 | KETONE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE - The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament. | 2015-08-27 |
20150239880 | LIGHT EMITTING MATERIAL, COMPOUND, AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME - To provide a material useful as a light emitting material of an organic light emitting device. A light emitting material comprising a compound represented by the general formula (1) wherein X represents O, S, N—R | 2015-08-27 |
20150239881 | HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS - Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active. | 2015-08-27 |
20150239882 | NOVEL MONOHYDRATE OF AZAADAMANTANE DERIVATIVES - The invention relates to a crystalline monohydrate of (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.1 | 2015-08-27 |
20150239883 | NEW COMPOUNDS - The invention relates to new pyridopyrazine and naphthyridine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. | 2015-08-27 |
20150239884 | INHIBITOR COMPOUNDS - The present invention relates to compounds of formula I | 2015-08-27 |
20150239885 | PI3K AND/OR MTOR INHIBITOR - The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, a stereoisomer or a solvate thereof, wherein R | 2015-08-27 |
20150239886 | SUBSTITUTED FUSED TRICYCLIC COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF - The present invention relates to substituted fused tricyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. | 2015-08-27 |
20150239887 | PROCESS FOR THE PREPARATION OF DIPEPTIDYLPEPTIDASE INHIBITORS - Provided is a process for the preparation of linagliptin of Formula I, comprising deprotecting a compound of Formula II wherein R | 2015-08-27 |
20150239888 | MODULATORS OF TOLL-LIKE RECEPTOR 7 - The present application includes a compound of Formula I or II: | 2015-08-27 |
20150239889 | PYRAZOLOPYRIMIDINE COMPOUND - Provided is a pyrazolopyrimidine compound represented by formula (I) having an HIF-PHD inhibitory effect, or a pharmaceutically acceptable salt thereof. | 2015-08-27 |
20150239890 | CRYSTAL OF N-[2-(AMINO)-2-METHYLPROPYL]-2-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-- 6-CARBOXAMIDE - An object is to provide a crystal of anagliptin, which has a high purity and is excellent in stability, low in hygroscopicity, and has a characteristic of easily dissolving into water, and a method for producing the crystal. An anagliptin crystal showing a powder X-ray diffraction pattern substantially the same as in FIG. | 2015-08-27 |
20150239891 | SUBSTITUTED PYRROLOPYRIMIDINYLAMINO-BENZOTHIAZOLONES AS MKNK KINASE INHIBITORS - The present invention relates to substituted pyrrolopyrimidinylamino-benzothiazolone compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients. | 2015-08-27 |
20150239892 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases - This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases. | 2015-08-27 |
20150239893 | Amide Compounds for Treatment of Complement Mediated Disorders - Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R | 2015-08-27 |