| 35th week of 2009 patent applcation highlights part 65 |
| Patent application number | Title | Published |
|---|
| 20090217395 | Promoter Mutations that Increase Amyloid Precursor Protein Expression - The present invention relates to mutations in the amyloid precursor protein (APP) promoter region, whereby the mutations cause a significant increase in APP expression. The increase in APP expression is related to Alzheimer's disease, and the mutations can be used in Alzheimer's disease diagnosis, or in the construction of transgenic animal models for studying Alzheimer's disease. | 2009-08-27 |
| 20090217396 | Inflammation models in neurodegenerative and arthritic disorders - Disclosed are compositions and methods for inducing temporally conditional mediators or inflammation and the transgenic animals produced by these compositions and method that can be used as models of inflammatory disease. | 2009-08-27 |
| 20090217397 | Cre-lox based gene knockdown constructs and methods of use thereof - The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo. | 2009-08-27 |
| 20090217398 | METHODS TO IDENTIFY FAT AND LEAN ANIMALS USING CLASS PREDICTORS - A combination comprising two or more polynucleotides that are differentially expressed in fat animals compared to lean animals or two or more proteins produced by the expression of such polynucleotides is disclosed. The combination and probes based upon the combination are used for formulating a prognosis that an animal is likely to become fat, developing a diagnosis that an animal is fat, screening substances to determine if they are useful for modulating the amount of adipose tissue on an animal, and detecting the differential expression of one or more genes differentially expressed in fat animals compared to lean animals in a sample. Methods for using class predictor gene profiles to identify fat and lean animals are also disclosed. | 2009-08-27 |
| 20090217399 | Lentiviral Vectors That Provide Improved Expression And Reduced Variegation After Transgenesis - The present invention provides new lentiviral vectors that include an anti-repressor element (ARE) and, optionally, a scaffold attachment region (SAR). The lentiviral vectors provide expression of a heterologous nucleic acid in at least 50% of the cells of multiple cell types when used for lentiviral transgenesis. In certain embodiments of the invention the heterologous nucleic acid encodes an RNAi agent such as an shRNA. The invention further provides transgenic nonhuman animals generated using a lentiviral vector that includes an ARE and optional SAR. In addition, the invention provides a variety of methods for using the vectors including for achieving gene silencing in eukaryotic cells and transgenic animals, and methods of treating disease. The invention also provides animal models of human disease in which one or more genes is functionally silenced using a lentiviral vector of the invention. | 2009-08-27 |
| 20090217400 | Enzymes, cells and methods for site specific recombination at asymmetric sites - The present invention relates to enzymes, compositions and methods for catalyzing asymmetric recombination of non-palindromic recombination sites in a cell free system, in isolated cells or in living organisms. The enzymes and methods of the invention are suitable for mediating specific recombinations between DNA sequences comprising specific recombination sites without being limited to strict palindromic symmetry within each recombination site. | 2009-08-27 |
| 20090217401 | Human Monoclonal Antibodies To Programmed Death 1(PD-1) And Methods For Treating Cancer Using Anti-PD-1 Antibodies Alone or in Combination with Other Immunotherapeutics - The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually. | 2009-08-27 |
| 20090217402 | METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF PEPTIDASES IN MACROPHAGE AND MACROPHAGE-LIKE CELLS - Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects, methods are provided for enhancing or suppressing the immune function of a host by increasing or decreasing, respectively, expression of a target peptidase in host macrophage and macrophage-like cells. Such methods for enhancing or suppressing the immune function of a host by increasing or inhibiting (suppressing or silencing) expression of a target peptidase in host macrophage and macrophage-like cells find use in methods for treating and/or preventing a number of diseases and conditions, including cancer, viral and/or bacterial infection, Alzheimer's disease, tissue transplant rejection, autoimmune diseases, and chronic inflammatory diseases. The invention also provides compositions and research tools related to these methods, including vectors for increasing or inhibiting the expression of a peptidase in macrophage and macrophage-like cells, macrophage and macrophage-like cells transfected with these vectors, genetically modified mice that over-express a target peptidase or in which expression of a target peptidase has been disrupted, and selective modulators of peptidase activity in macrophages as well as methods for identifying and using such modulators. | 2009-08-27 |
| 20090217403 | Means and methods for generating a t cell against an antigen of interest - The invention provides a method for generating a T cell comprising a T cell receptor capable of specifically binding an antigen of interest, comprising: —providing a hematopoietic stem cell and/or a precursor cell of a T cell with a nucleic acid sequence comprising at least part of a rearranged gene encoding a TCR chain, or a functional equivalent thereof; and—allowing for differentiation of said stem cell and/or precursor cell and generation of at least one T cell derived from said stem cell and/or precursor cell. | 2009-08-27 |
| 20090217404 | Cell-based RNA interference and related methods and compositions - The invention provides, among other things, methods for performing RNA interference (RNAi) in stem cells (such as embryonic stem cells) and methods for using such stem cells in vivo. The invention also provides various animal models based on conditional/inducible, reversible, tissue-specific/spacial, and/or developmental stage-specific/temporal RNAi of certain target genes, which animal model may be useful for, e.g., drug target identification and/or validation. | 2009-08-27 |
| 20090217405 | Isolated nucleotide sequences responsible for the tomato high pigment-1 mutant phenotypes (hp-1 and hp-1w) and uses thereof - The present invention provides isolated nucleotide sequences responsible for the tomato high pigment 1 (hp-1) and high pigment 1 | 2009-08-27 |
| 20090217406 | Plant cells and plants with increased tolerance to environmental stress - This invention relates generally to transformed plant cells and plants comprising an inactivated or down-regulated gene resulting in increased tolerance and/or resistance to environmental stress as compared to non-transformed wild type cells and methods of producing such plant cells or plants. This invention further relates generally to transformed plant cells with increased tolerance and/or resistance to an environmental stress as compared to a corresponding non-transformed wild type plant cell, methods of producing, screening for and breeding such plant cells or plants and method of detecting stress in plants cells or plants. | 2009-08-27 |
| 20090217407 | INBRED BROCCOLI LINE BRM50-3906 - Inbred broccoli lines, designated BRM50-3906 are disclosed. The invention relates to the seeds of inbred broccoli lines BRM50-3906, to the plants of inbred broccoli lines BRM50-3906, and to methods for producing a broccoli plant produced by crossing the inbred line BRM50-3906 with itself or another broccoli line. The invention further relates to hybrid broccoli seeds and plants produced by crossing the inbred line BRM50-3906 with another broccoli line. | 2009-08-27 |
| 20090217408 | PLANTS AND SEED OF INBRED CORN VARIETY DS-046358 - Disclosed is the seed of an inbred corn line, designated DS-046358, a sample of which is deposited under ATCC Accession No. PTA-9052. Also disclosed are plants, or parts thereof, grown from the seed of the cultivar, plants having the morphological and physiological characteristics of inbred corn line DS-046358, and methods of using the plant or parts thereof in a corn breeding program. | 2009-08-27 |
| 20090217409 | METHODS FOR INCREASING THE FREQUENCY OF APOMIXIS EXPRESSION IN ANGIOSPERMS - The present invention is directed to the seed-to-seed perpetuation of hybrid vigor and other traits through apomixis (asexual seed formation) in flowering plants (angiosperms). More particularly, to predictable methods for producing, from sexual or facultatively-apomictic plants, progeny plants that express an increased percentage of apomictic seed set or one or more elements of apomixis. This invention uses: plant cyto-embryology procedures to identify and select a plant or group of plants that possess appropriate genetic variability for initiation times and durations of megasporogenesis (female meiosis), embryo sac formation, egg and central cell formation and maturation, fertilization, embryony and endosperm formation; plant breeding procedures to produce numerous and divergent genetically-recombined early to late generation progeny such that embryo sac formation preempts megasporogenesis and embryony preempts fertilization; and plant cyto-embryology or progeny test procedures to select segregant plants that express an increased frequency of one or more elements of apomixis. | 2009-08-27 |
| 20090217410 | Method of Constructing Transgenic Ice Plant - The present invention provides a method of transforming common ice plant by gene transfer using a microorganism belonging to the genus | 2009-08-27 |
| 20090217411 | SALT RESPONSIVE GENES USEFUL FOR GENERATING SALT RESISTANT TRANSGENIC PLANTS - The present invention relates to a transgenic plant comprising one or more plant cells transformed with exogenous nucleic acid encoding a | 2009-08-27 |
| 20090217412 | Alteration of Plant Embryo/Endosperm Size During Seed Development - Isolated nucleic acid fragments and recombinant constructs comprising such fragments useful for altering embryo/endosperm size during seed development are disclosed along with a method of controlling embryo/endosperm size during development in plants using such recombinant constructs. | 2009-08-27 |
| 20090217413 | PLANT GENETIC SEQUENCES ASSOCIATED WITH VACUOLAR PH AND USES THEREOF - The present invention relates generally to the field of plant molecular biology and agents useful in the manipulation of plant physiological or biochemical properties. More particularly, the present invention provides genetic and proteinaceous agents capable of modulating or altering the level of acidity or alkalinity in a cell, group of cells, organelle, part or reproductive portion of a plant. Even more particularly, the present invention contemplates methods and agents for modulating or altering pH levels in the vacuole of a cell, group of cells, organelle, part or reproductive portion of a plant. The present invention further provides genetically altered plants, plant parts, progeny, subsequent generations and reproductive material including flowers or flowering parts having cells exhibiting an altered vacuolar pH compared to a non-genetically altered plant. The present invention still further provides methods for modulating or altering flower color in a plant. Even more particularly, the present invention provides for down regulation of pH in a plant which results in a bluer color in the plant; especially in the flower | 2009-08-27 |
| 20090217414 | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement - Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources. Polypeptides encoded by the polynucleotide sequences are also provided. The disclosed polynucleotides and polypeptides find use in production of transgenic plants to produce plants having improved properties. | 2009-08-27 |
| 20090217415 | Polynucleotide Encoding a Maize Herbicide Resistance Gene and Methods for Use - This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently select the best lines for breeding strategies by avoiding sensitive lines. | 2009-08-27 |
| 20090217416 | Genetic marker linked to gene locus involved in barley resistance to yellow mosaic disease and use thereof - Through creation of a detailed linkage map of barley and QTL analysis thereof, there have been found five genetic markers linked to gene locus involved in barley resistance to yellow mosaic disease and situated on barley 1H chromosome, two genetic markers linked to gene locus involved in barley resistance to yellow mosaic disease and situated on barley 2H chromosome barley resistance to yellow mosaic disease, five genetic markers linked to gene locus involved in barley resistance to yellow mosaic disease and situated on barley 3H chromosome, four genetic markers linked to gene locus involved in barley resistance to yellow mosaic disease and situated on barley 4H chromosome, and two genetic markers linked to gene locus involved in barley resistance to yellow mosaic disease and situated on barley 5H chromosome. | 2009-08-27 |
| 20090217417 | Combination of lipid metabolism proteins and uses thereof - Described herein are inventions in the field of genetic engineering of plants, including combinations of nucleic acid molecules encoding LMPs to improve agronomic, horticultural, and quality traits. This invention relates generally to the combination of nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to LMP nucleic acid sequences encoding lipid metabolism proteins (LMP) and the use of these combinations of these sequences, their order and direction in the combination, and the regulatory elements used to control expression and transcript termination in these combinations in transgenic plants. In particular, the invention is directed to methods for manipulating fatty acid-related compounds and for increasing oil level and altering the fatty acid composition in plants and seeds. The invention further relates to methods of using these novel combinations of polypeptides to stimulate plant growth and/or to increase yield and/or composition of seed storage compounds. | 2009-08-27 |
| 20090217418 | Means and methods of controlling plant seed germination - A method of controlling germination of seed is provided in which a nucleic acid encoding a protein which causes inhibition of germination is transformed into a plant, operably linked with a promoter that expresses during germination. The protein is one in which a restoring substance can be applied to the seed and restores germination. Also provided is an amylase germination preferred promoter. | 2009-08-27 |
| 20090217419 | EXPRESSION CASSETTES FOR VASCULAR TISSUE-PREFERENTIAL EXPRESSION IN PLANTS - The present invention relates to expression cassettes comprising transcription regulating sequences with vascular tissue-preferential or vascular tissue-specific expression profiles in plants obtainable from | 2009-08-27 |
| 20090217420 | Method for transformation using mutant acetolactate synthase gene - Transformed cells are efficiently selected using a mutant ALS gene having high specificity to PC herbicides. The transformation method comprises the steps of: transforming a host cell with a recombination vector containing a gene of interest and a gene coding for a mutant acetolactate synthase having mutation of glycine corresponds to position 95 of the amino acid sequence of a wild-type acetolactate synthase derived from rice to alanine; culturing the transformed cell obtained in the former step in the presence of a pyrimidinyl carboxy herbicide; and wherein the gene coding for the mutant acetolactate synthase is used as a selection marker. | 2009-08-27 |
| 20090217421 | Engineering Resistance to Pierce's Disease by Expression of a Xyella Fastidiosa Heca-Like Hemagglutinin Protein - (Xj), a Gram-negative, xylem-limited bacterium, is the causal agent of several economically important plant diseases, including Pierce's disease (PD) and Citrus Variegated Chlorosis (CVC). Identified is a HccA-like hemagglutinin gene in | 2009-08-27 |
| 20090217422 | Nematode resistant grape rootstock '9407-14' - Rootstock ‘9407-14’ is a cross of L6-1 ( | 2009-08-27 |
| 20090217423 | CE43-67B INSECTICIDAL COTTON - The present application relates an insect resistant transgenic cotton plant. In particular, it relates to a specific event, designated CE43-67B. The application also relates to polynucleotides which are characteristic of the CE43-67B event, plants comprising said polynucleotides, and methods of detecting the CE43-67B event. | 2009-08-27 |
| 20090217424 | CONSTITUTIVE PROMOTERS FROM POPLAR AND USES THEREOF - The present invention relates to nucleic acid molecules corresponding to regulatory portions of genes whose expression is constitutive. The invention also relates to compositions and methods of using the same to regulate the expression, in a constitutive manner, of genes and/or any kind of nucleotide sequences in a plant. Nucleic acid molecules and its compositions include novel nucleotide sequences for constitutive promoter identified in and isolated from poplar ( | 2009-08-27 |
| 20090217425 | Driving apparatus - A driving apparatus is provided with: a stage structure on which a medium having a small recording domain is mounted; and a facing structure which is provided with at least one small action structure, which faces the medium, for performing a predetermined action to the medium, and which is displaced relatively on a predetermined flat surface with respect to the stage structure, the facing structure comprising a facing-side position detecting unit for detecting a relative reference position of the facing structure with respect to the stage structure, the stage structure comprising a stage-side position detecting unit for detecting a relative reference position of the facing structure with respect to the stage structure. | 2009-08-27 |
| 20090217426 | SCANNING MEASUREMENT INSTRUMENT - A scanning measurement instrument is capable of simultaneously achieving both higher accuracy and higher speed in autonomous scanning measurement. The instrument includes a path information holding unit for holding information about the path of the center position of a tip of a scanning probe at past tip center positions with respect to the current tip center position curing autonomous scanning measurement performed with the scanning probe; a path reference direction setting unit for setting an approximate straight line direction of the path as a pith reference direction; a traveling direction setting unit for setting the path reference direction as a traveling direction; a movement control unit for controlling a moving unit such that the scanning probe is moved in the traveling direction; and a normal direction setting unit for setting the normal direction of a measurement surface according to the traveling directior. | 2009-08-27 |
| 20090217427 | Actinidia chinensis plant named 'S600' - A new and distinct | 2009-08-27 |
| 20090217428 | Actinidia chinensis plant named 'W45' - A new and distinct | 2009-08-27 |
| 20090217429 | Actinidia chinensis plant named 'Y118' - A new and distinct | 2009-08-27 |
| 20090217430 | Actinidia chinensis plant named 'X60' - A new and distinct | 2009-08-27 |
| 20090217431 | Actinidia chinensis plant named 'Y368' - A new and distinct | 2009-08-27 |
| 20090217432 | Catena malbec 'Clone 16' - A special Malbec grapevine clone from Mendoza Argentina, herewith denominated Catena Malbec ‘Clone 16’ which shows a unique vineyard and winemaking profile from the rest of the Malbec grapevine population in Mendoza, Argentina. This Malbec grapevine clone is characterized by its small cluster size and medium cluster weight; very compact cluster form; very small berry size and weight; medium vigor; medium to high level of millendrage (shot berries); very high level of polyphenol and tannin; very high aromatic intensity and mid palate flavor depth. | 2009-08-27 |
| 20090217433 | Catena malbec 'Clone 13' - A distinct Malbec grape variety from Mendoza Argentina, herewith denominated ‘Catena Malbec Clone 13’ which shows a unique vineyard and winemaking profile from the rest of the Malbec grapevine population in Mendoza, Argentina. This Malbec grape variety is characterized by its medium cluster size and weight; compact cluster form; medium berry size and weight; medium vigor; low level of millendrage (shot berries); medium-high level of polyphenols and tannins; high aromatic intensity and excellent mid-palate flavor depth. | 2009-08-27 |
| 20090217434 | Catena malbec 'Clone 17' - A distinct Malbec grape variety from Mendoza Argentina, herewith denominated ‘Catena Malbec Clone 17’ which shows a unique vineyard and winemaking profile from the rest of the Malbec grapevine population in Mendoza, Argentina. This Malbec grape variety is characterized by its very low cluster size and weight; loose cluster form; medium berry size and weight; medium to high vigor; medium to high level of millendrage (shot berries); very high level of polyphenols; a low level of tannins, and high color intensity. | 2009-08-27 |
| 20090217435 | Catena malbec 'Clone 15' - A distinct Malbec grape variety from Mendoza Argentina, herewith denominated ‘Catena Malbec Clone 15’ which shows a unique vineyard and winemaking profile from the rest of the Malbec grapevine population in Mendoza, Argentina. This Malbec grape variety is characterized by its medium cluster size and very low cluster weight; loose cluster form; very small berry size and weight; very low vigor; extremely low level of millendrage (shot berries); medium to low level of polyphenols and tannins; very high level of color intensity and flavor complexity. | 2009-08-27 |
| 20090217436 | STRAWBERRY PLANT NAMED 'VALOR' - This invention relates to a new and distinct variety of strawberry plant named ‘VALOR’. This new strawberry plant named ‘VALOR’ is primarily adapted to the growing conditions of the central coast of California, and is primarily characterized by its medium plant size; medium to large fruit; red to dark red fruit color; strong fruit skin firmness; medium to dark green foliage; good fruit flavor; medium sized foliage and short fruiting trusses. | 2009-08-27 |
