| 34th week of 2010 patent applcation highlights part 45 |
| Patent application number | Title | Published |
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| 20100216613 | Multiple Layered Resistance Cables With Built In Resistance Handles And Interchangeable Hand Grips With Attachments - The instant invention describes a resistant-type device, adaptable for use in exercise, utilizing a resistance cable constructed of multiple layers of resistance and protection. The resistance cable has a resilient inner core having a plurality of elastic members arranged in a substantially parallel manner. The plurality of elastic members are interlaced together to form a unitary stretchable main body unit, a first elastic looped portion positioned at a first end, and a second elastic looped portion positioned at a second end. In addition to the inner resilient core, resistance cable also contains at least one outer member and a protective layer coaxially aligned with the inner core. The outer member length is substantially coextensive with the length of the elastic inner core unitary stretchable main body unit. The device therefore, provides for the extension of the unitary stretchable main body unit from a first resting position to a second extended position upon application of a pulling force, whereby resistance to stretching of the unitary stretchable main body unit when extended from the first resting position to the second extended position upon application of the pulling force is greater than the resistance of each of the plurality of elastic members individually. | 2010-08-26 |
| 20100216614 | PORTABLE DUAL INCLINE ADJUSTABLE RESISTANCE ABDOMINAL MUSCLE EXERCISE MACHINE - An abdominal muscle exercise machine of a push-pull type that includes an elbow sliding support plate with handle bars; a knee sliding support plate with swiveling knee cups; elastic resistance bands attached between the elbow and knee support plates and the end stabilizer bars; parallel sets of shafts at the front and rear end of the machine connected to the sliding support plates; a center rod with support legs to raise it off the ground; quick release clamps attached to the parallel shafts; and end support rods with end caps at the front and rear end of the machine. The machine has a dual incline angle for both the elbows and knees to pull and push against during exercise and may be adjusted in range of motion using quick release clamps. The machine may also be easily folded closed for storing in a compact space. | 2010-08-26 |
| 20100216615 | AB WEB SYSTEMS - The Ab Web device of the present invention may assist users in effectively working out without having to use and store cumbersome fitness equipment. This innovative item is ideal for individuals looking for a substantially simple way to flatten and strengthen their abdominals without having to lie on their back, thereby decreasing the likelihood of straining the exerciser's neck muscles. The present Ab Web device disclosed herein preferably includes roller gloves having braking mechanisms located proximate digit-tip portions, and leg roller units that may be removably coupled to the roller gloves via connection band(s). | 2010-08-26 |
| 20100216616 | Exercising Device - An exercising device includes a disc shaped member capable of rotating about a point of rotation. The exercising device also includes an elongated supporting member connected to the point of rotation of the disc shaped member. Further, the exercising device includes a braking mechanism carried by the elongated supporting member. The braking mechanism is capable of contacting the disc shaped member to apply a resistance to the rotation of the disc shaped member. Moreover, the exercising device includes a foot engaging member connected to the disc shaped member. The foot engaging member is adapted to be operated by feet of an individual. The operation of the foot engaging member by the individual against the resistance to the rotation applied by the braking mechanism exercises the individual. | 2010-08-26 |
| 20100216617 | METHOD AND APPARATUS FOR MANUFACTURING BOXES MADE OF PAPER OR CARDBOARD - A method for manufacturing boxes made of paper or cardboard, whereby the boxes have a base or a lid with a glued-on sidewall and the sidewalls are formed from a strip with a beginning, an end, and connecting tabs on a long side. First, the connecting tabs are bent by about 90°. Next, the strip beginning is placed against the lateral surface of a cylindrical matrix, whose cross section corresponds to the cross section of the box, with the aid of a patrix and attached by vacuum. Next, the matrix is rotated. In so doing, the strip is suctioned by vacuum onto the lateral surface and held in place. After application of an adhesive at the beginning or end of the strip, the beginning and end of the strip are glued together. A base along whose periphery an adhesive bead is applied is then pressed onto the connecting tabs. After the adhesive has hardened, the finished box can be removed from the matrix. | 2010-08-26 |
| 20100216618 | METHOD AND DEVICE FOR PRODUCING FILTER INSERTS - A method and a device for producing filter inserts ( | 2010-08-26 |
| 20100216619 | CREASING METHOD - A resiliently foldable product ( | 2010-08-26 |
| 20100216620 | CENTRIFUGE - The invention relates to a centrifuge, in particular a laboratory centrifuge, with a centrifuge rotor to hold material and with an electric motor, exhibiting a stator, a rotor that is associated with the stator and a fastening means for the localization of the electric motor at a stationary support and for a torque proof connection of the rotor with the centrifuge rotor, in which the centrifuge rotor features a recess on a face side that is facing the electric motor, in which the recess of the centrifuge rotor is designed such, that the electric motor can be at least partially positioned in said recess. | 2010-08-26 |
| 20100216621 | Centrifugal Separator Assembly - A centrifugal separator assembly including a polygonal separator chamber formed of planar wall sections joined with each other to provide a substantially gas tight structure and having at least four pairs of planar opposite wall sections. The chamber includes a tapered portion formed by having a first inward bending in each of the wall sections. The tapered portion extends as a discharge channel for separated particles from the separator chamber, which discharge channel is formed of first and second pairs of opposite wall sections being perpendicular to each other. In the discharge channel for separated particles, the first pair of wall sections extends into the area between the second pair of wall sections. | 2010-08-26 |
| 20100216622 | Fixed Angle Centrifuge Rotor With Helically Wound Reinforcement - A centrifuge rotor includes a rotor body having first and second axial ends and a circumferential sidewall extending therebetween. The rotor body has a plurality of wells for receiving sample containers to be processed in the rotor. The rotor further includes an elongate reinforcement extending around the circumferential sidewall of the rotor body along a helical path. At least two portions of the elongate reinforcement interlock at one or more specific points on the surface of the rotor. | 2010-08-26 |
| 20100216623 | CLEAN-IN-PLACE DECANTER CENTRIFUGE - A clean-in-place decanter centrifuge for processing a combined liquid and solid material to separate the solid material from the liquid. The centrifuge is designed for use in the food processing industry, particularly for dairy products, and therefore has fluid injectors for cleaning all surfaces within the centrifuge including the opposed mating surfaces which function as non-contacting seal mechanisms. The centrifuge has no metal-to-metal contact areas within the interior of the bowl and scroll assembly. In one embodiment, the outer wall of the bowl and scroll assembly comprises a plurality of drain lines located in the rear wall section of the bowl to allow essentially all liquid to drain from the bowl and scroll assembly. In another embodiment, the bowl hub comprises at least one drain line to allow lubrication oil to drain into said cavity and prevent ingress of lubrication oil into said bowl and scroll assembly. In another embodiment, the discharge housing further comprises an enclosure bound by the interior surface of the exterior wall of the discharge housing, partitions within the discharge housing, and the outer wall of the rotating bowl, said partitions being separated from the outer wall of the rotating bowl by non-contacting seals whereby fine solid material that migrates into said enclosure is removable from the discharge housing by liquid sprayed from one or more fluid injectors inserted into said enclosure. | 2010-08-26 |
| 20100216624 | GLASS COMPOSITION FOR LAMP, GLASS PART FOR LAMP, AND PROCESS FOR PRODUCING LAMP OR GLASS COMPOSITION FOR LAMP - A glass composition for lamps includes the following by weight percent: SiO | 2010-08-26 |
| 20100216625 | GLASS FOR LASER MACHINING - A glass for laser processing that is processed through laser beam irradiation, wherein the glass for laser processing has a composition that satisfies the following relationships: | 2010-08-26 |
| 20100216626 | Aluminum resistant refractory composition and method - A refractory composition for use in contact with molten aluminum and molten aluminum alloys containing a refractory aggregate, a binder, and a treatment additive comprising a source of Sr. Methods comprising contacting a refractory composition with the Sr source to improve the resistance of the refractory to molten aluminum attack are also disclosed. Preferred treatment agents comprise Sr nitrate, Sr carbonate, Sr sulfate and Sr oxide. | 2010-08-26 |
| 20100216627 | METHOD OF MAKING MIXED METAL OXIDE CERAMICS - A method of making dielectric ceramics containing mixed metal oxides is provided. The method comprises the steps of at least partially coating a metal oxide powder with a metal hydroxide or metal oxide, compacting the coated powder with one or more additional metal compounds or metal compound precursors, and directly sintering the compact in a single step. The method of the invention may be used to avoid occurrence of significant quantities of one or more undesired but thermodynamically or kinetically favored side products. The method of the invention may also be used to synthesize perovskites, in particular lead-magnesium-niobium (PMN), lead-magnesium-niobium-lead-titanium (PMN-PT) perovskites, or lead zirconate titanate (PZT). | 2010-08-26 |
| 20100216628 | ON-BOARD FUEL DESULFURIZATION UNIT - A method for regenerating at least one impurity-adsorbing sorbent bed includes passing impurity-containing fluid through the impurity-adsorbing bed. The impurity-adsorbing sorbent bed adsorbs an impurity in the impurity-containing fluid to produce a purified fluid. A portion of the purified fluid is sent back through the impurity-adsorbing sorbent bed that contains the adsorbed impurity. The impurity-adsorbing sorbent bed is exposed to microwave energy to desorb the impurity adsorbed on the impurity-adsorbing sorbent bed. | 2010-08-26 |
| 20100216629 | Method for Preparing Metalloalumino-Phosphate (MEAPO) Molecular Sieve - The present invention also relates to a method for preparing metalloaluminophosphate (MeAPO) molecular sieve said method comprising:
| 2010-08-26 |
| 20100216630 | REFORMING CATALYST - In one embodiment, a reforming catalyst can include indium, tin, and a catalytically effective amount of a group VIII element for one or more reforming reactions. Typically, at least about 25%, by mole, of the indium is an In(3+) species based on the total moles of indium after exposure for about 30 minutes in an atmosphere including about 100% hydrogen, by mole, at a temperature of about 565° C. Usually, no more than about 25%, by mole, of the tin is a Sn(4+) species based on the total moles of tin after exposure for about 30 minutes in an atmosphere including about 100% hydrogen, by mole, at a temperature of about 565° C. | 2010-08-26 |
| 20100216631 | METHOD AND APPARATUS FOR FLUID-LIQUID REACTIONS - A method and apparatus for fluid-liquid reactions including gas-liquid and liquid-liquid reactions. The method and apparatus is suitable for mixing a fluid phase species and a liquid phase species to facilitate chemical reaction between said phases. The apparatus comprises a reactor vessel with a plurality of orificed plates and flow control means which initiates and maintains uniform mixing and efficient dispersion of a fluid-liquid mixture within the reactor vessel. | 2010-08-26 |
| 20100216632 | High Stability, Self-Protecting Electrocatalyst Particles - High-stability, self-protecting particles encapsulated by a thin film of a catalytically active noble metal are described. The particles are preferably nanoparticles comprising a passivating element having at least one metal selected from the group consisting of columns IVB, VB, VIB, and VIIB of the periodic table. The nanoparticle is preferably encapsulated by a Pt shell and may be either a nanoparticle alloy or a core-shell nanoparticle. The nanoparticle alloys preferably have a core comprised of a passivating component alloyed with at least one other transition metal. The core-shell nanoparticles comprise a core of a non-noble metal surrounded by a shell of a noble metal. The material constituting the core, shell, or both the core and shell may be alloyed with one or more passivating elements. The self-protecting particles are ideal for use in corrosive environments where they exhibit improved stability compared to conventional electrocatalyst particles. | 2010-08-26 |
| 20100216633 | Oil- based thermo-neutral reforming with a multi-component catalyst - A method is provided for the thermo-neutral reforming of liquid hydrocarbon fuels which employs a Ni,Ce | 2010-08-26 |
| 20100216634 | METHOD FOR MANUFACTURING HONEYCOMB STRUCTURE - A method for manufacturing a honeycomb structure includes molding a wet mixture containing an aluminum titanate powdery material to form a honeycomb molded body. The aluminum titanate powdery material contains about 40% to about 60% by mass of Al | 2010-08-26 |
| 20100216635 | REVERSE WRITE ERASABLE PAPER - An image-forming medium and methods for forming and imaging the medium are provided. The disclosed medium can be strongly colored under room illumination (or deliberate UV) and can be selectively discolored at an appropriate light wavelength to form an image. In one embodiment, the image-forming medium can include a substrate (e.g., a sheet of paper), a photochromic material incorporated with the substrate, and a photo-absorbing material incorporated with the photochromic material. Exemplary methods for using the image-forming medium to make a transient image can include first forming the image-forming medium by applying a coating solution containing photochromic material to the substrate or paper. The image-forming medium can have a medium color and can then be selectively exposed to a radiation through a mask to convert the photochromic material from a colored form to a colorless form and thus to form an image having a color contrast with its background. | 2010-08-26 |
| 20100216636 | FUNGICIDAL SUBSTANCE COMBINATIONS - The present invention relates to novel active compound combinations comprising the known fungicidally active compounds N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, metalaxyl and strobilurin (3), which are highly suitable for controlling unwanted phytopathogenic fungi. Moreover, the invention relates to a method for the curative or preventive treatment of phytopathogenic fungi on plants or useful plants, in particular to the treatment of seed, for example seed of cereals, and not least to the treated seed itself. | 2010-08-26 |
| 20100216637 | Synergistic Insecticide Mixtures - The invention relates to insecticidal mixtures comprising, as active compounds, in each case two compounds from the series of the chloronicotinyl insecticides, and to the use of these mixtures for controlling animal pests. | 2010-08-26 |
| 20100216638 | HERBICIDALLY ACTIVE BICYCLIC 1,3-DIONE COMPOUNDS - Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides. | 2010-08-26 |
| 20100216639 | GYPSUM SOIL CONDITIONER - Soil conditioning products according to the invention preferably include gypsum and organic binder. One or more of an oil, a polymeric binder, a gel, fibers and wax could also be included. The invention further includes surface materials comprising a soil and a soil conditioning product according to the invention. Other materials may be added to any of these soil conditioning products or surface materials. | 2010-08-26 |
| 20100216640 | FUNGICIDAL COMPOSITIONS - A composition suitable for control of diseases caused by phytopathogens comprising (A) a compound of Formula (I) wherein R | 2010-08-26 |
| 20100216641 | Low VOC and Stable Plant Growth Regulator Liquid and Granule Compositions - The invention relates to low VOC plant growth regulator compositions comprising less than about 25% of volatile organic compounds (VOCs). The compositions preferably comprise 6-benzyladenine (6-BA) or forchlorfenuron (CPPU). Also provided are methods of using the compositions. | 2010-08-26 |
| 20100216642 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME - There is provided a compound represented by the formula (I): | 2010-08-26 |
| 20100216643 | CONTROL OF PLANT STRESS TOLERANCE, WATER USE EFFICIENCY AND GENE EXPRESSION USING NOVEL ABA RECEPTOR PROTEINS AND SYNTHETIC AGONISTS - The present invention provides methods of regulating plant stress tolerance. | 2010-08-26 |
| 20100216644 | LIMONENE-CONTAINING HERBICIDE COMPOSITIONS, HERBICIDE CONCENTRATE FORMULATIONS AND METHODS FOR MAKING AND USING SAME - Provided are methods, kits and compositions for killing, controlling or suppressing a plant by administering to surfaces of the plant a herbicide composition comprising a herbicidally effective limonene component and an emulsifying agent in an aqueous emulsion, wherein the composition has a pH greater than 5. Also provided are methods, kits and compositions for killing, controlling or suppressing a plant, comprising administering to surfaces of the plant a herbicide composition comprising a herbicidally effective limonene component and an emulsifying agent in an aqueous emulsion, wherein the composition includes a wetting agent. Also provided are methods, kits and compositions for killing, controlling or suppressing a plant, comprising administering to surfaces of the plant a herbicide composition comprising a herbicidally effective limonene component and an emulsifying agent in an aqueous emulsion, wherein the composition has a pH greater than 5 and includes a wetting agent. | 2010-08-26 |
| 20100216645 | Superconducting connection between MgB2 superconducting wires via a compressed element made from HTS powder - A method for connecting two or more superconducting wires ( | 2010-08-26 |
| 20100216646 | METHOD OF PATTERNING OXIDE SUPERCONDUCTING FILMS - A process for preparing a superconductor article includes depositing a precursor solution onto a substrate to form a precursor film, the precursor solution comprising precursor components to a rare earth-alkaline earth metal-transition metal oxide in one or more solvents, decomposing the precursor film to form an intermediate film comprising the rare earth metal, the alkaline earth metal, and the transition metal of the first precursor solution, selectively removing portions of the intermediate film, wherein a patterned intermediate film is obtained, and treating the patterned intermediate film to form a rare earth-alkaline earth metal-transition metal oxide superconductor. | 2010-08-26 |
| 20100216647 | Method for superconducting connection between MgB2 superconducting wires via a MgB2 matrix made from a boron powder compressed element infiltrated with Mg - A method for superconductingly connecting two or more wires ( | 2010-08-26 |
| 20100216648 | SYNTHESIS OF SEQUENCE-VERIFIED NUCLEIC ACIDS - The invention relates to methods and devices for preparing synthetic nucleic acids. | 2010-08-26 |
| 20100216649 | Methods for protein interaction determination - Provided are compositions and methods for identifying pairs of interacting proteins. The pair of plasmids is adapted for use in a modified two hybrid system wherein each plasmid comprises a recombinase recognition site. The method comprises the steps of providing cDNAs encoding test polypeptides, inserting the cDNAs into the first and second plasmids, recombining the first and second plasmids to obtain recombined plasmids, isolating and digesting the recombined plasmids to obtain cDNAs encoding pairs of interacting proteins, and determining the sequence of the digested fragments to determine pairs of interacting proteins. | 2010-08-26 |
| 20100216650 | METHOD OF PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE, APPARATUS FOR PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE, AND PROGRAM FOR PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE - The object of the present invention is to provide a method of predicting a higher-order structure of a nucleic acid sequence typified by a G quartet structure, and an apparatus and a program that execute the method. The method according to the present invention relates to a method of predicting a nucleic acid higher-order structure that predicts a higher-order structure of a nucleic acid sequence, the method, including the steps of: extracting bases capable of forming a higher-order structure as a higher-order structure candidate from said nucleic acid sequence; extracting bases capable of forming a stem structure as a stem structure candidate from said nucleic acid sequence; and searching an optimal combinatorial structure based on the higher-order structure candidate and the stem structure candidate. | 2010-08-26 |
| 20100216651 | VIRAL POLYHEDRA COMPLEXES AND METHODS OF USE - Cypoviruses and baculoviruses are notoriously difficult to eradicate because the virus particles are embedded in micron-sized protein crystals called polyhedra. The remarkable stability of polyhedra means that like bacterial spores these insect viruses remain infectious for years in soil. Although these unique in vivo protein crystals have been extensively characterized since the early 1900s, their atomic organization remains elusive. Here we describe the 2 crystal structure of both recombinant and infectious silkworm cypovirus polyhedra determined using 5-12 micron crystals purified from insect cells. These are the smallest crystals yet used for de novo X-ray protein structure determination. It was found that polyhedra are made of trimers of the viral polyhedrin protein and contain nucleotides. Although the shape of these building blocks is reminiscent of some capsid trimers, polyhedrin has a new fold and has evolved to assemble in vivo into 3-D cubic crystals rather than icosahedral shells. The polyhedrin trimers are extensively cross-linked in polyhedra by non-covalent interactions and pack with an exquisite molecular complementarity similar to that of antigen-antibody complexes. The resulting ultra-stable and sealed crystals shield the virus particles from environmental damage. The structure suggests that polyhedra can serve as the basis for the development of robust and versatile nanoparticles for biotechnological applications such as in cell culture systems, microarrays and biopesticides. | 2010-08-26 |
| 20100216652 | Low Level Fluorescence Detection at the Light Microscopic Level - The present invention discloses methods of removing unwanted fluorescence from a sample by photobleaching said sample to enhance detection of proteins and fragments thereof, polynucleotides and fragments thereof, and biomolecules and fragments thereof in a sample by contacting said proteins, polynucleotides and biomolecules with a fluorescent reporter, wherein said fluorescent reported comprises a fluorescent semiconductor crystal or SCN, wherein said SCN further comprises a targeting moiety. | 2010-08-26 |
| 20100216653 | USE OF POLYMORPHISMS IN THE TMEM132D GENE IN THE PREDICTION AND TREATMENT OF ANXIETY DISORDERS - The present invention relates to methods, compositions, kits and reagents for the diagnosis and treatment of anxiety disorders. | 2010-08-26 |
| 20100216654 | BIOMARKERS OF PROSTATE CANCER AND USES THEREOF - The present invention includes biomolecules and use of these biomolecules for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate. In an embodiment, the present invention provides methods for detecting biomolecules within a biological sample as well as a database comprising of mass profiles of biomolecules specific for healthy subjects, subjects having a non-malignant disease of the prostate and subjects having prostate cancer. The invention further includes kits for differential diagnosis of prostate cancer and/or non-malignant disease of the prostate in a biological sample. | 2010-08-26 |
| 20100216655 | SEQUENCE VARIANTS FOR INFERRING HUMAN PIGMENTATION PATTERNS - The present invention discloses variants that are predictive of human pigmentation patterns. The invention furthermore relates to variants that are useful for determining risk of skin cancer, including melanoma and basal cell carcinoma. The disclosed variants can be utilized for the determination of the natural pigmentation patterns of a human individual, and for determining a susceptibility to melanoma and basal cell carcinoma, from a sample of genetic material. Methods and kits including the variants described are useful in e.g. forensic testing and diagnostic applications. | 2010-08-26 |
| 20100216656 | METHODS OF ENZYMATIC DISCRIMINATION ENHANCEMENT AND SURFACE-BOUND DOUBLE-STRANDED DNA - Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nuclease treatment to improve the quality of hybridization signals on high density oligonucleotide arrays. In another embodiment, the present invention provides methods of using ligation reactions to improve the quality of hybridization signals on high density oligonucleotide arrays. In yet another embodiment, the present invention provides libraries of unimolecular or intermolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific interactions between the double-stranded oligonucleotides, and peptides, proteins, drugs and RNA. In a related aspect, the present invention provides libraries of conformationally restricted probes on a solid support. The probes are restricted in their movement and flexibility using double-stranded oligonucleotides as scaffolding. The probes are also useful in various screening procedures associated with drug discovery and diagnosis. The present invention further provides methods for the preparation and screening of the above libraries. | 2010-08-26 |
| 20100216657 | PCR-FREE SAMPLE PREPARATION AND DETECTION SYSTEMS FOR HIGH SPEED BIOLOGIC ANALYSIS AND IDENTIFICATION - Provided herein are biologic sample preparation and analysis systems that are rapid, portable, robust detection system for multiplexed detection of bio-threats, and which can be ruggedized to operate in harsh environments. A new method of detection called Combinatorial Probe Analysis (CPA), which provides an exponential increase in detection reliability, has been incorporated into these systems. This type of analysis greatly reduces false positives and false negatives; in addition it is reusable and eliminates special storage requirements for reagents. Specific technical advancements in the optimization of hybridization assays for nucleic acid detection on porous polymer monoliths (PPM) are also disclosed. Performing rapid and complete solubilization of viruses, vegetative bacteria and bacterial spores with an ultra high temperature solubilization protocol is also described. The systems provided herein provides the ability to perform rapid highly multiplexed analysis of a variety of bioagents, including bacteria viruses, and protein biotoxins. The systems and assays described herein are perform completely automated sample preparation and analysis, in a time frame of five minutes or less. The assay is simple in design allowing users in personal protective equipment to easily operate the system. The disclosed systems are robust, simple to use, and address the goals of the first responder community. | 2010-08-26 |
| 20100216658 | Modified Nucleic Acid Nanoarrays and Uses Therefor - The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use. | 2010-08-26 |
| 20100216659 | METHODS AND COMPOSITIONS FOR INDENTIFYING BINDING PARTNERS FROM LIBRARIES OF BIOMOLECULES - The present invention provides methods for identifying cognate binding pairs from two libraries of biomolecules (e.g., polypeptides). The methods typically involve displaying a first library of candidate biomolecules (e.g., receptors or epitopes) on a first replicable genetic package (e.g., a cell surface display platform) and displaying a second library of candidate biomolecules (e.g., ligands) on a second replicable genetic package (e.g., a phage display platform), contacting the first library with the second library, and then selecting members of the first library to which a member of the second library is bound. Also provided in the invention are compositions and kits for carrying out the methods of the invention. | 2010-08-26 |
| 20100216660 | NOVEL METHODS FOR FUNCTIONAL ANALYSIS OF HIGH-THROUGHPUT EXPERIMENTAL DATA AND GENE GROUPS IDENTIFIED THEREFROM - The present invention relates generally to groups of genes that can be used to diagnose and differentiate between types of specific diseases such as breast cancer. The groups of genes can be further used to develop diagnostic kits for the specific diseases. The diagnostic kits can also differentiate between sub-categories of a disease to help identify the appropriate treatment regimen for a patient. | 2010-08-26 |
| 20100216661 | Diagnostic Assay - The present invention relates to mimotopes of blood group antigens, methods for identifying mimotopes of blood group antigens and methods for identifying antibodies to blood group antigens using said mimotopes. | 2010-08-26 |
| 20100216662 | Inhibition of Placenta Growth Factor (PLGF) Mediated Metastasis and/or Angiogenesis - The present invention concerns methods and compositions for inhibiting angiogenesis and/or tumor growth, survival and/or metastasis. In particular embodiments, the methods and compositions may concern ligands against placenta growth factor (P1GF), such as BP-1, BP-2, BP-3 or BP-4. Some methods may comprise administering one or more P1GF ligands, alone or in combination with one or more other agents, such as chemotherapeutic agents, other anti-angiogenic agents, immunotherapeutic agents or radioimmunotherapeutic agents to a subject. The P1GF ligands are effective to inhibit angiogenesis, tumor cell motility, tumor metastasis, tumor growth and/or tumor survival. In certain embodiments, P1GF ligands may be administered to subjects to ameliorate other angiogenesis related conditions, such as macular degeneration. In some embodiments, P1GF expression levels may be determined by any known method to select those patients most likely to respond to P1GF targeted therapies. | 2010-08-26 |
| 20100216663 | NOVEL PROTEINS WITH TARGETED BINDING - Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention. | 2010-08-26 |
| 20100216664 | Method - The present invention relates, in one aspect, to a method for determining the severity of a disease attributed to at least one genetic mutation in one or more of the genes encoding haemoglobin polypeptide chains, comprising the steps of: (a) providing a sample from said subject; and (b) determining the presence of one or more diagnostic markers:
| 2010-08-26 |
| 20100216665 | DETECTION OF IMMOBILIZED NUCLEIC ACID - The present invention provides methods for determining the presence of immobilized nucleic acid employing unsymmetrical cyanine dyes that are derivatives of thiazole orange, a staining solution and select fluorogenic compounds that are characterized as being essentially non-genotoxic. The methods comprise immobilizing nucleic acid, single or double stranded DNA, RNA or a combination thereof, on a solid or semi solid support, contacting the immobilized nucleic acid with an unsymmetrical cyanine dye compound and then illuminating the immobilized nucleic acid with an appropriate wavelength whereby the presence of the nucleic acid is determined. The cyanine dye compounds are typically present in an aqueous staining solution comprising the dye compound and a tris acetate or tris borate buffer wherein the solution facilitates the contact of the dye compound and the immobilized nucleic acid. Typically the solid or semi-solid support is selected from the group consisting of a polymeric gel, a membrane, an array, a glass bead, a glass slide, and a polymeric microparticle. Preferably, the polymeric gel is agarose or polyacrylamide. The methods employing the non-genotoxic compounds represent an improvement over commonly used methods employing ethidium bromide wherein the present methods retain the advantages of ethidium bromide, ease of use and low cost, but without the disadvantageous, known mutagen requiring special handling and waste procedures. | 2010-08-26 |
| 20100216666 | METHOD OF PERFORMING A BIOLOGICAL ASSAY - The present invention relates to a method of pooling samples to be analyzed for a categorical variable, wherein the analysis involves a quantitative measurement of an analyte, said method of pooling samples comprising providing a pool of n samples wherein the amount of individual samples in the pool is such that the analytes in the samples are present in a molar ratio of x | 2010-08-26 |
| 20100216667 | METHOD FOR DETERMINING COMPATIBILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT WITH MATERIALS - Disclosed is a system or matrix approach for determining compatibility of a pharmaceutically active substance, such as small molecule drug candidate, therapeutic proteins, peptides, vaccines or RNAi, with materials used in the research and development of pharmaceuticals, including plastics, polymers, resins, rubbers, elastomers, glass and steel. | 2010-08-26 |
| 20100216668 | PROBE ARRAY SUBSTRATE AND METHOD FOR PRODUCING THE SAME, AND PROBE ARRAY AND METHOD FOR PRODUCING THE SAME - A probe array substrate suitable for forming a probe array that has high packing density, that can hold sufficient amounts of probe molecules, and that has little variation in the amounts of probe molecules. A plurality of arrayed probe-holding portions are defined by recesses, and isolating grooves are formed between the adjacent probe-holding portions to prevent probe solutions introduced into the probe-holding portions from spreading to adjacent probe-holding portions. Inner surfaces of the probe-holding portions are made hydrophilic, whereas inner surfaces of the isolating grooves are made hydrophobic. Liquid-introducing protrusions are formed in the probe-holding portions. | 2010-08-26 |
| 20100216669 | Capillary-Channel Probes For Liquid Pickup, Transportation And Dispense Using Stressy Metal - Fluidic conduits, which can be used in microarraying systems, dip pen nanolithography systems, fluidic circuits, and microfluidic systems, are disclosed that use channel spring probes that include at least one capillary channel. Formed from spring beams (e.g., stressy metal beams) that curve away from the substrate when released, channels can either be integrated into the spring beams or formed on the spring beams. Capillary forces produced by the narrow channels allow liquid to be gathered, held, and dispensed by the channel spring probes. Because the channel spring beams can be produced using conventional semiconductor processes, significant design flexibility and cost efficiencies can be achieved. | 2010-08-26 |
| 20100216670 | WATER-BASED FLUID FOR PREVENTING THE FORMATION OF W/O EMULSIONS OR FOR RESOLVING W/O EMULSIONS ALREADY FORMED IN POROUS MATRICES - The invention relates to a water-based fluid for applications in the oil field, comprising non-ionic surfactants, stable at temperatures ranging from 10 to 90° C., having an HLB ranging from 8 to 20 and soluble in water, with a saline content ranging from 0 to 60% by weight, and possibly salts. The fluid can be conveniently used as completion fluid for preventing the formation of inverse W/O emulsions or as a remedial fluid for resolving emulsions already formed in oil wells in which oil-based mud has been used. | 2010-08-26 |
| 20100216671 | MICROEMULSIONS TO CONVERT OBM FILTER CAKES TO WBM FILTER CAKES HAVING FILTRATION CONTROL - Single phase microemulsions improve the removal of filter cakes formed during drilling with oil-based muds (OBMs). The single phase microemulsion removes oil and solids from the deposited filter cake. Optionally, an acid capable of solubilizing the filter cake bridging particles may also be used with the microemulsion. In one non-limiting embodiment the acid may be a polyamino carboxylic acid. Skin damage removal from internal and external filter cake deposition can be reduced. In another optional embodiment, the single phase microemulsion may contain a filtration control additive for delaying the filter cake removal, destruction or conversion. | 2010-08-26 |
| 20100216672 | Treatment fluids comprising relative permeability modifiers and methods of use - Treatment fluids for and methods of treating subterranean formations are provided. In certain embodiments, a method is provided comprising providing a treatment fluid comprising a relative permeability modifier, a delayed filter cake breaker, and a carrier fluid, contacting at least a portion of a filter cake in a subterranean formation with the treatment fluid, and removing at least a portion of the filter cake. | 2010-08-26 |
| 20100216673 | Methods and Compositions of Controlling the Rheology of a Diutan-Containing Well Treatment Fluid at High Temperatures - The invention provides a method for treating a subterranean formation penetrated by a wellbore, the method comprising the steps of formulating a treatment fluid and introducing the treatment fluid through the wellbore. The treatment fluid comprises water; diutan; and a sufficient amount of salt to increase the density of the treatment fluid to at least 8.5 lb/gal, wherein at least 50% by weight of the salt is selected from the group consisting of: bromide salts, non-bromide salts having a higher salting-in effect than bromide according to the Hofmeister series as measured by the salt's effect on the cloud point of poly(ethylene oxide) that has a molecular weight of 4×10 | 2010-08-26 |
| 20100216674 | MULTICOMPONENT VISCOELASTIC SURFACTANT FLUID AND METHOD OF USING AS A FRACTURING FLUID - There is a viscoelastic fluid. The fluid has one or more cationic surfactants selected from the group consisting of certain quaternary salts, certain amines, and combinations thereof; one or more anionic polymers/anionic surfactants; one or more of certain zwitterionic/amphoteric surfactants; and water. There is also a method of fracturing a subterranean formation. The viscoelastic fluid is pumped through a wellbore and into a subterranean formation at a pressure sufficient to fracture the formation. There is also a method for gravel packing a subterranean formation. | 2010-08-26 |
| 20100216675 | Method for the control of hydroperoxide-induced oxidation in formulated lubricating oils by use of ionic liquids as additives - The resistance to oxidation of a lubricating oil is enhanced by the addition to the lubricating oil of an additive amount of an ionic liquid. | 2010-08-26 |
| 20100216676 | LUBRICATING OIL COMPOSITION - A lubricating oil composition includes: a lubricating base oil; and an imide compound, an amide compound and an aliphatic amine compound mixed with the lubricating base oil. A content of the imide compound is 300 to 1000 ppm by mass of the total amount of the composition in terms of nitrogen. A content of the amide compound is 380 to 1300 ppm by mass of the total amount of the composition in terms of nitrogen. A content of the aliphatic amine compound is 35 to 360 ppm by mass of the total amount of the composition in terms of nitrogen. | 2010-08-26 |
| 20100216677 | METHODS FOR PRESERVING TECHNICAL PRODUCTS SUCH AS FUELS AND LUBRICANTS WITH A MICROBICIDAL COMPOSITION - Methods for preserving technical products such as fuels and lubricants with a microbicidal composition. The composition is made up of at least one formaldehyde donor compound and at least one antioxidant. The antioxidant is either a gallic ester, a phenol derivative, a L-ascorbic acid, including salts and derivatives thereof, a tocopherol or one of its associated derivatives. | 2010-08-26 |
| 20100216678 | Lubricant compositions containing glycerol tri-esters - A lubricant composition comprising a Group I-IV or Group VI lube base stock and a glycerol tri-ester of the formula: | 2010-08-26 |
| 20100216679 | FABRIC CONDITIONERS - The invention provides a fabric conditioner composition comprising: a) a photo-bleach, which is preferably a singlet oxygen photo-bleach and present at a level of 0.00001 to 0.05 wt %, suitable photo-bleaches are water-soluble phthalocyanine compound and/or a xanthines; b) a quaternary ammonium fabric conditioner, other than 1,2 bis[hardened tallowoyloxy]-3-thrimethylammoniumpropane chloride, and typically of the 2HT or TEA-quat type, and, c) perfume and/or pro-fragrance. Where pro-fragrance is present it preferably comprises a compound with at least two C═C double-bonds is preferably a lipid, and preferably a plant oil. Suitable lipids include olive oil, palm oil, canola oil, squalene, sunflower seed oil, wheat germ oil, almond oil, coconut oil, grape seed oil, rapeseed oil, castor oil, corn oil, cottonseed oil, safflower oil, groundnut oil, poppy seed oil, palm kernel oil, rice bran oil, sesame oil, soybean oil, pumpkin seed oil. jojoba oil and mustard seed oil. Use of a composition can improve the freshness of laundered articles and improve the perfume longevity of laundered articles. | 2010-08-26 |
| 20100216680 | CLEANING COMPOSITIONS, METHODS AND MATERIALS FOR REDUCING NUCLEIC ACID CONTAMINATION - The present invention relates to methods using cleaning compositions for the reduction of nucleic acid contamination. More particularly, the present invention relates to cationic compositions that bind to, and can remove, extraneous nucleic acids, polynucleotides, and DNA from the surface of a substrate. Preferably, the cationic compositions include a substance with a molecular weight of 500 Da or more. The present invention finds utility as a surface decontamination agent in PCR and other related DNA amplification techniques. | 2010-08-26 |
| 20100216681 | CLEANING COMPOSITION AND CLEANING METHOD FOR LIQUID CRYSTALLINE POLYESTER PRODUCTION DEVICE USING THE SAME - The present invention provides a cleaning composition used for cleaning a device for producing a liquid crystalline polyester, the composition comprising (A) glycols, (B) amines and (C) a compound selected from the group consisting of cyclic esters, amides and sulfoxides, wherein the content of the component (B) is 5 to 40% by weight and the content of the component (C) is 5 to 30% by weight, both being with respect to the total weight of the cleaning composition. | 2010-08-26 |
| 20100216682 | Methods for Improving Multiple Protein Properties - The present invention provides efficient methods for obtaining a protein with one or more beneficial attributes in industrial, consumer or pharmaceutical applications. In some preferred embodiments, the present invention provides methods for producing superior enzymes for a given application through screening an abbreviated set of candidate enzymes. | 2010-08-26 |
| 20100216683 | Cleaning Product - Liquid, aqueous washing or cleaning product formulation, comprising a) at least one washing- or cleaning-active enzyme; b) 1,2-propylene glycol; and c) nonionic surfactant of the general formula R | 2010-08-26 |
| 20100216684 | PERFUME PARTICLES - The invention relates to a process for the manufacture of core-shell perfume particles by emulsion polymerisation and to the products obtainable by such a process. The core of the particles comprises a perfume and the shell (which preferably comprises an aminoplast polymer) also comprises a non-ionic deposition aid (such as locust bean gum) which is substantive to textiles. The process of the invention is characterised in that, during the emulsion polymerisation step, the solids content of the polymerisation mixture does not fall below 25% wt. The particles obtained by the process are suitable for inclusion in laundry products and show significantly improved deposition and retention onto fabrics being laundered as compared with particles formed at lower solids levels. | 2010-08-26 |
| 20100216685 | Array of Self-Adhering Articles and Merchandise Display System for Identifying Product Types to Users - An array of self-adhesive cleaning products, the array having a first self-adhesive cleaning product, the product being a gel, and a second self-adhesive cleaning product, the second product being a solid. | 2010-08-26 |
| 20100216686 | CLEANING AGENT - The present invention herein provide a cleaning agent which comprises (A) an aqueous solution or an aqueous dispersion containing a linear poly(meth)acrylamide having an average molecular weight of not less than 5×10 | 2010-08-26 |
| 20100216687 | FABRIC CONDITIONERS - Compositions comprising unsaturated fatty chains have reduced or eliminated base off-odour with the incorporation of a photobleach. | 2010-08-26 |
| 20100216688 | PEPTIDOMIMETIC MACROCYCLES - The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides. | 2010-08-26 |
| 20100216689 | CYTOTOXIC T CELL ACTIVATOR COMPRISING EP4 AGONIST - Disclosed is a substance which has a low molecular weight, can be applied in a simpler manner, and has an immunopotentiating activity against cancer and/or a microorganism-mediated infectious disease. | 2010-08-26 |
| 20100216690 | Pegylated Single-Chain Insulin - The present invention is related to a single-chain insulin comprising the B- and the A-chain of human insulin or analogues thereof connected by a connecting peptide having from 3-35 amino acid residues, wherein the single-chain insulin comprises at least one PEG group attached to at least one lysine residue in the single-chain insulin molecule and/or to the B1 N terminal amino acid residue. The PEGylated single-chain insulins may comprise up to 4 PEG groups which may be the same or different. | 2010-08-26 |
| 20100216691 | Protease Stabilized, Pegylated Insulin Analogues - Novel PEGylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H. The PEGylation is at B29K. | 2010-08-26 |
| 20100216692 | Acidic Insulin Preparations Having Improved Stability - The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and combinations thereof; a surfactant or combinations of two or more surfactants; optionally a preservative or combinations of two or more preservatives; and optionally an isotonicizing agent, buffers or further excipients or combinations thereof, the pharmaceutical formulation having a pH in the acidic range. | 2010-08-26 |
| 20100216693 | COMPOSITIONS AND METHODS OF TREATING DIABETES - The invention features compositions comprising insulin and C-peptide and methods for treating diabetes, using such compositions. The invention further features compositions comprising insulin analogues and C-peptide and the uses thereof for treating diabetes. | 2010-08-26 |
| 20100216694 | ANTIDIABETIC TRICYCLIC COMPOUNDS - Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. | 2010-08-26 |
| 20100216695 | SECOND GENERATION LOW OXYGEN AFFINITY PEGYLATED HEMOGLOBINS AS OXYGEN-CARRYING PLASMA EXPANDERS - Provided are hemoglobins having at least two chemical modifications that lower oxygen affinity, hemoglobins chemically modified by the addition of glyceraldehyde-3-phosphate, and hemoglobins having at least two specific chemical modifications. PEGylated versions of these hemoglobins are also provided, as are certain tetraPEGylated and diPEGylated hemoglobins. Methods of modifying a hemoglobin are additionally provided, as are methods of making a hemoglobin. Pharmaceutical compositions and blood substitutes using these hemoglobins are further provided, as are methods of treating a subject using these pharmaceutical compositions and blood substitutes. | 2010-08-26 |
| 20100216696 | Compounds and methods for treating cancer - The present invention provides a method of treating cancer involving administering an insulin-like growth factor-1 receptor (IGF-1 receptor) agonist and an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an IGF-1-receptor ligand coupled to an anti-cancer chemotherapeutic agent. Also provided are compounds for treating cancer comprising an insulin-receptor ligand coupled to an anti-cancer chemotherapeutic agent. | 2010-08-26 |
| 20100216697 | PHARMACEUTICAL COMPOSITION, SUBSTRATE COMPRISING A PHARMACEUTICAL COMPOSITION, AND USE OF A PHARMACEUTICAL COMPOSITION - The invention relates to the use of a pharmaceutical composition for the local treatment or prevention of a tissue infection at an infection site, the pharmaceutical composition comprising at least two different antibiotics of group A or pharmaceutically acceptable derivatives thereof, or an antibiotic of group A and at least one antibiotic of group B or pharmaceutically acceptable derivatives thereof. Group A comprises primarily intracellular active antibiotics working as inhibitor of bacterial RNA polymerase; as inhibitor of gyrase; or as inhibitor of bacterial protein synthesis. Group B comprises primarily extracellular active antibiotics working as inhibitor of bacterial cell wall synthesis; or inhibitor of bacterial protein synthesis; or by direct destabilisation or rupture of the bacterial cell wall. | 2010-08-26 |
| 20100216698 | LIQUID FORMULATIONS OF G-CSF - Provided are pharmaceutical liquid formulations of G-CSF, which are stable over a long time period and substantially free of excipients, as well as ready-to-use syringes containing such formulations and corresponding kits. | 2010-08-26 |
| 20100216699 | SEMI-SYNTHETIC GLYCOPEPTIDES HAVING ANTIBACTERIAL ACTIVITY - Semi-synthetic glycopeptides having antibacterial activity are described. Also described are processes of preparing such semi-synthetic glycopeptides by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or the monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in mild acidic medium to give the amino acid-4 monosaccharide; protection of the amino groups in the molecule; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Also included are the process of conversion of the amide group in amino acid-3 on these scaffolds to various acylureas, acylamide, acylsulfonamide, acylsulfonylurea derivatives and aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction procedures. Further provided herein are pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, including bacterial infections. | 2010-08-26 |
| 20100216700 | METHODS OF TREATING OCULAR DISORDERS - This invention is directed to treatments of ocular disorders using emulsions and molecular dispersions in the form of a gel comprising a hydrophobic ocular agent. | 2010-08-26 |
| 20100216701 | Protein Kinase C Inhibitors for Prevention of Insulin Resistance and Type 2 Diabetes - The present invention provides peptides and peptide analogs capable of inhibiting the activity of protein kinase C. The invention discloses use of such peptides and analogs for preparation of pharmaceutical compositions and methods for prevention, delay, suppression or treatment of type 2 diabetes using such compositions. | 2010-08-26 |
| 20100216702 | VEGF ANALOGS AND METHODS OF USE - Modified VEGF proteins that inhibit VEGF-mediated activation or proliferation of endothelial cells are disclosed. The analogs may be used to inhibit VEGF-mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases, and skin disorders. | 2010-08-26 |
| 20100216703 | Inhibitors of PDE4 and Methods of Use - The inventors have succeeded in discovering that the p75 neurotrophin receptor (p75NTR) is directly involved in the degradation of cAMP via interaction of its intracellular domain with phosphodiesterase 4A4/5 (PDE4A4/5). Provided herein are methods and compositions for the treatment of conditions of PDE4A4/5 and p75NTR expression (such as pulmonary disease and nerve regeneration) by blocking the interaction of PDE4A4/5 and p75NTR, as well as methods for the screening of agents useful in such applications. | 2010-08-26 |
| 20100216704 | NOVEL GENES AND PROTEINS THAT HOME TO DEVELOPING MICROVESSELS - Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia. | 2010-08-26 |
| 20100216705 | HUMAN GROWTH HORMONE FORMULATIONS - Formulations containing complexed human growth hormone crystals are described. Also described are needleless injection systems for crystalline proteins. | 2010-08-26 |
| 20100216706 | Ghrelin Protects Substantia Nigra Dopamine Neurons - A method of treating neurodegeneration of substantia nigra pars compacta (SNpc) dopamine neurons and compositions therefor are provided. | 2010-08-26 |
| 20100216707 | COSMETIC USE OF APOLIPOPROTEIN D TYPE PROTEINS - The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation. The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis. | 2010-08-26 |
| 20100216708 | Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses - A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications. | 2010-08-26 |
| 20100216709 | SYSTEMIC INSULIN-LIKE GROWTH FACTOR-1 THERAPY REDUCES DIABETIC PERIPHERAL NEUROPATHY AND IMPROVES RENAL FUNCTION IN DIABETIC NEPHROPATHY - The present invention provides methods of treatment of patients suffering from the complications of blood sugar disorders: diabetic peripheral neuropathy and diabetic nephropathy by administration of IGF-1 via protein therapy or gene therapy. It relates to methods of treating an individual having a diabetic disorder or a hyperglycemic disorder, comprising administering to the individual an effective amount of a DNA vector expressing IGF-1Eb or IGF-1Ec in vivo or an effective amount of at the IGF-1Eb or IGF-1Ec protein in the early hyperalgesia stage or in patients that have advanced to the hyposensitivity stage. Treatment at the early hyperalgesia stage prevents subsequent hyposensitivity with increases or maintenance of sensory nerve function. IGF-1Eb or IGF-1Ec treatment also increases muscle mass and improves overall mobility, which indicates a treatment-related improvement in motor function. Treatment with IGF-1Eb or IGF-1Ec at the hyposensitivity stage reverses hyposensitivity and improves muscle mass and overall health. Systemic IGF-1 provides a therapeutic modality for treating hyposensitivity associated with DPN. In addition, IGF-1Eb or IGF-1Ec provides a therapeutic modality for treating diabetic nephropathy. IGF-1Eb or IGF-1Ec improves renal function as evidenced by a modulation in serum albumin concentration and a reduction in urine volume and protein levels. IGF-1Eb or IGF-1Ec also reduces diabetic glomerulosclerosis. | 2010-08-26 |
| 20100216710 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS - This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on neuronal regeneration and repair and to identify agents which will block or promote the inhibitory effects on neuronal outgrowth are provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of myelin on neural regeneration by affecting arginase activity or putrescine and derivative polyamine levels in a neuron. Methods for regulating and for promoting (or repressing) neuronal growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with conditions, disorders or diseases, comprising the step of administering at least one of the compositions according to this invention, are provided. | 2010-08-26 |
| 20100216711 | Protease-Stable, Cell Wall-Lysing Enzymes - The present invention relates to a modified polypeptide with a biological activity to lyse cell walls of bacteria, wherein the polypeptide has no caspase, clostripain, enterokinase, factor Xa, granzyme B, | 2010-08-26 |
| 20100216712 | NUCLEIC ACID CODIFYING FOR A UTROPHIN TRANSCRIPTION SPECIFIC REGULATING PROTEIN, PROTEIN CODIFIED THEREBY AND USES THEREOF - The present invention relates to a nucleic acid molecule comprising a nucleotide sequence codifying for a protein characterized in having at least four zinc finger domains and in modulating the transcription of the utrophin gene by binding to a nucleotidic sequence comprised in a utrophin gene untranscribed regulatory sequence. Protein codified thereby and uses thereof. | 2010-08-26 |
