33rd week of 2013 patent applcation highlights part 57 |
Patent application number | Title | Published |
20130211075 | AMIDE DERIVATIVE AND USE THEREOF - The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) | 2013-08-15 |
20130211076 | Method for preparing substituted N-(3-amino-quinoxalin-2-yl)-sulfonamides and their intermediates N-(3-chloro-quinoxalin-2-yl)-sulfonamides - The present invention provides a new synthesis for preparing N-(3-amino-quinoxalin-2-yl)-sulfonamides of general formulae (I) or (I′) and intermediates sulfonamides of formula (II) or (II′): | 2013-08-15 |
20130211077 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES - The invention is directed to a process for the preparation of a cyclic carbamate starting with o-aminobenzyl alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C | 2013-08-15 |
20130211078 | PREPARATION OF METHIONINE OR SELENOMETHIONINE FROM HOMOSERINE VIA A CARBAMATE INTERMEDIATE - Provided herein are processes for the production of methionine or selenomethionine from homoserine. In particular, the processes proceed via the production of carbamate intermediates. | 2013-08-15 |
20130211079 | SUBSTITUTED HETEROCYCLES AS THERAPEUTIC AGENTS FOR TREATING CANCER - MDM2 and MDM4 proteins prevent apoptosis of cancer cells by negatively regulating the transcription factor p53. Compounds according to Formula I | 2013-08-15 |
20130211080 | PROCESS FOR THE MANUFACTURE OF TMHQ - The present invention is directed to a process for the manufacture of 2,3,5-trimethyl-hydro-p-benzoquinone comprising the following steps: a) hydrogenating 2,6-dimethyl-p-benzoquinone with hydrogen in the presence of a hydrogenation catalyst in an organic solvent to obtain 2,6-dimethyl-hydro-p-benzoquinone; b) reacting 2,6-dimethyl-hydro-p-benzoquinone with a secondary amine and formal-dehyde in an organic solvent to obtain 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone; c) reacting 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone with hydrogen in the presence of a hydrogenolysis catalyst in an organic solvent to obtain 2,3,5-trimethylhydro-p-benzoquinone; wherein the organic solvent in all steps a), b) and c) is independently selected from the group consisting of methyl tert.-butyl ether, ethyl tert.-butyl ether, tert.-amyl ether, methoxycyclopentane and any mixtures thereof. Preferably the organic solvent used in all steps a), b) and c) is the same. | 2013-08-15 |
20130211081 | METHOD FOR STEREOSELECTIVE SYNTHESIS OF BICYCLIC HETEROCYCLIC COMPOUNDS - The invention relates to a method for the stereoselective preparation of a compound of formula (5), optionally in the form of the tautomers thereof, | 2013-08-15 |
20130211082 | Synthesis of Cyclopentaquinazolines - A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4-[N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801). | 2013-08-15 |
20130211083 | PROCESS FOR THE PREPARATION OF ANAGRELIDE AND ANALOGUES THEREOF - The present invention relates to a novel process for producing anagrelide, 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin 2(3H)-one, or certain analogues thereof. The process of the invention also provides improved processes for producing key intermediates required for the synthesis of anagrelide or certain analogues thereof. | 2013-08-15 |
20130211084 | FREE CRYSTAL OF TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE - To provide a crystal of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90. The present invention provides a crystal of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a medicament comprising the same, an anticancer agent comprising the same, and the like. | 2013-08-15 |
20130211085 | PROCESS FOR THE PREPARATION OF ENANTIOMERIC FORMS OF 2,3-DIAMINOPROPIONIC ACID DERIVATIVES - The disclosure relates to a process for the preparation of the enantiomeric forms of 2,3-diaminopropionic acid derivatives of formula I, | 2013-08-15 |
20130211086 | PURIFICATION OF POSACONAZOLE AND OF POSACONAZOLE INTERMEDIATES - The present invention relates to a process for the preparation of a hydrogen chloride (HCl) salt of a compound of formula (I) wherein Y | 2013-08-15 |
20130211087 | 7-AZA-SPIRO[3,5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - The present invention is directed to 7-aza-spiro[3.5]nonane-7-carboxylate derivatives of the Formula I. The compounds of the invention are inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The invention also relates to processes for the preparation of compounds of the Formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them. | 2013-08-15 |
20130211088 | FLUORINATED PERYLENE-BASED SEMICONDUCTING MATERIALS - The present invention provides a compound of formula | 2013-08-15 |
20130211089 | INDENOPYRIDINE DERIVATIVES - Disclosed is a compound of formula (I) | 2013-08-15 |
20130211090 | METHOD FOR THE PRODUCTION OF 5-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE - The present invention relates to a process for preparing 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile of the formula (I) | 2013-08-15 |
20130211091 | CRYSTALLINE FORMS OF MARAVIROC PHOSPHATE AND PROCESS FOR MARAVIROC AMORPHOUS FORM - The present invention provides novel crystalline forms of maraviroc phosphate, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides novel process for the preparation of maraviroc amorphous form and pharmaceutical composition comprising it. | 2013-08-15 |
20130211092 | SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS - The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases. | 2013-08-15 |
20130211093 | Process for the Preparation of 1-Hydroxy-6-Substituted Pyridones - Disclosed herein is a cost effective and environmentally friendly process to prepare 1-hydroxy-6-substituted pyridones from 2,6-dichloropyridine. The process includes the steps of (a) reacting 2,6-dichloropyridine with hydrogen peroxide in the presence of trifluoroacetic acid at a first temperature to produce a first intermediate containing (1) trifluoroacetic acid and (2) 2,6-dichloropyridine N-oxide and/or salts thereof; (b) adding sulfuric acid to the first intermediate to provide a second intermediate; (c) removing trifluoroacetic acid from the second intermediate to provide a composition containing 2,6-dichloropyridine N-oxide and/or salts thereof which is essentially free of trifluoroacetic acid; (d) reacting 2,6-dichloropyridine N-oxide and/or salts thereof from step (c) with RXH and a base wherein each R is independently a substituted or unsubstituted hydrocarbyl group having between 1 and 20 carbon atoms, X is oxygen or sulfur, to produce a corresponding 2,6-disubstituted-pyridine N-oxide; and (e) heating the disubstituted compound thereby producing the 1-hydroxy-6-substituted pyridone. | 2013-08-15 |
20130211094 | METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS - Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof. | 2013-08-15 |
20130211095 | NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS - The present invention provides novel methods for synthesizing PPARγ sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases. | 2013-08-15 |
20130211096 | Novel Metathesis Catalysts - There is disclosed compounds of formula 1, their preparation, intermediates for the preparation and the use of the compounds of the formula 1 | 2013-08-15 |
20130211097 | DIPHOSPHONATE COMPOUND AND A METHOD FOR PREPARING THE SAME AND AN APPLICATION OF THE SAME - The present disclosure relates to a new diphosphonate compound, and the method to prepare the above new diphosphonate compound. The new diphosphonate compound exhibits an activity in inhibiting osteoclast equivalent to alendronate sodium, and a higher activity in affecting the proliferation of osteoplast than the positive control compounds, but the positive control exhibits a weaker effect on osteoblast proliferation. In experimental examples, an administration schedule for the diphosphonate compound is provided. | 2013-08-15 |
20130211098 | PROCESS FOR PREPARING 4-AMINO-5-BIPHENYL-4-YL-2-HYDROXYMETHYL-2-METHYL-PENTANOIC ACID COMPOUNDS - The invention provides processes for preparing intermediates useful for preparing compounds of the formula: | 2013-08-15 |
20130211099 | ASENAPINE MALEATE - Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof. | 2013-08-15 |
20130211100 | Method to Generate Novel Bioactive Molecules - The present invention describes a method to generate new chemical entities (NCEs) that have well-defined activities such as, but not limited to, anti-bacterial, antifungal and anthelmintic effects. The NCEs are generated through adaptive evolution of one microbe (the producer) against another organism or cell type (the target). The producer is made to compete against the target over time by co-culturing the two together and serially passing the producer organism until the producer adaptively evolves by synthesizing an NCE(s) that inhibits growth of or kills the target. The molecular structure of the chemical entity (or entities) is then clucidated using tools from genomics, molecular biology, computational biology, analytical chemistry, organic chemistry and related fields. | 2013-08-15 |
20130211101 | Crystalline Glycopyrrolate Tosylate - Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed. | 2013-08-15 |
20130211102 | CHEMICAL PROCESSES FOR THE MANUFACTURE OF SUBSTITUTED BENZOFURANS - The present invention relates to the scaled-up synthesis of biologically active compounds which display useful therapeutic activity in treating proliferative disorders. In particular the invention relates to process methods for the kilogram scale synthesis of a particular class of substituted benzofuran tubulin polymerisation inhibitors. | 2013-08-15 |
20130211103 | INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS - Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) | 2013-08-15 |
20130211104 | PREPARATION OF BICYCLO[2.2.2]OCTAN-2-ONE COMPOUNDS - The present invention relates to a new process for the preparation of 6-hydroxy-5-arylbicyclo[2.2.2]octan-2-one compounds of the formula (II); which may subsequently be further transformed to compounds of the formula (I): | 2013-08-15 |
20130211105 | ACYLATIONS IN MICRO REACTION SYSTEMS - A method for acylating tertiary alcohols and phenolic compounds with carboxylic acids or their anhydrides in micro-reaction systems wherein the acylation is effected in the absence of any catalyst including water at residence times of at most 30 minutes. | 2013-08-15 |
20130211106 | PRODUCTION OF GRAPHENE AND NANOPARTICLE CATALYSTS SUPPORTED ON GRAPHENE USING MICROWAVE RADIATION - Microwave irradiation is used to synthesize graphene and metallic nanocatalysts supported on graphene either by solid or solution phase. In solid phase methods, no solvents or additional reducing agents are required so the methods are “environmentally friendly” and economical, and the graphene and nanocatalysts are substantially free of residual contaminants. Recyclable, high efficiency Pd nanocatylysts are prepared by these methods. | 2013-08-15 |
20130211107 | PROCESS FOR THE PURIFICATION OF PHARMACEUTICALLY ACCEPTABLE SALTS - The present invention is concerned with a process in connection with the purification of a pharmaceutically acceptable salt of escitalopram or citalopram. | 2013-08-15 |
20130211108 | NOVEL PROCESS FOR THE PREPARATION OF (3S)-TETRAHYDROFURAN-3-YL (IS, 2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-(PHOSPHONOOXY) PROPYLCARBAMATE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS - The present invention relates to a novel process for the preparation of Fosamprenavir or its pharmaceutically acceptable salts thereof by using novel intermediates. | 2013-08-15 |
20130211109 | CRYSTALLINE FORMS OF CABAZITAXEL AND PROCESS FOR PREPARATION THEREOF - The present invention provides Crystalline Forms of 4-acetoxy-2α-benzoyloxy-5β-20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, i.e Cabazitaxel. The present invention also discloses methods for the preparation of Crystalline Forms of Cabazitaxel and pharmaceutical compositions thereof. | 2013-08-15 |
20130211110 | Process for manufacturing epichlorohydrin - Process for manufacturing epichlorohydrin, comprising: (a) preparing epichlorohydrin to obtain a mixture comprising epichlorohydrin and water; (b) subjecting the mixture obtained in step (a) to a liquid-liquid phase separation to separate at least one first fraction (I) comprising most of the epichlorohydrin which was contained in the mixture before separation and at least one second fraction (II) comprising most of the water which was contained in the mixture before separation; and (c) drawing off the fraction (I) and the fraction (II); wherein the volume V | 2013-08-15 |
20130211111 | METHOD OF SYNTHESIS OF SUBSTISTUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL - The present invention provides an efficient method of synthesizing and purifying dianhydrohexitols such as dianhydrogalactitol. In general, as applied to dianhydrogalactitol, the method comprises: (1) reacting dulcitol with a concentrated solution of hydrobromic acid at a temperature of about 80° C. to produce dibromogalactitol; (2) reacting the dibromogalactitol with potassium carbonate in t-butanol to produce dianhydrogalactitol; and (3) purifying the dianhydrogalactitol using a slurry of ethyl ether to produce purified dianhydrogalactitol. | 2013-08-15 |
20130211112 | METHOD FOR PRODUCING OXIDIZED OLEFIN THROUGH OLEFIN EPOXIDATION - A process for producing an alkylene oxide by olefin epoxidation, wherein said process comprises the steps of: (1) in a first olefin epoxidation condition, in the presence of a first solid catalyst, a first mixed stream containing a solvent, an olefin and H | 2013-08-15 |
20130211113 | Systems and Methods for Extracting Non-Polar Lipids from an Aqueous Algae Slurry and Lipids Produced Therefrom - Methods, systems, and apparatuses for extracting non-polar lipids from microalgae are achieved using a lipid extraction device having an anode and a cathode that forms a channel and defines a fluid flow path through which an aqueous slurry is passed. An electromotive force is applied across the channel at a gap distance in a range from 0.5 mm to 200 mm to cause the non-polar lipids to be released from the algae cells. The non-polar lipids can be extracted at a high throughput rate and with low concentrations of polar lipids such as phospholipids and chlorophyll. | 2013-08-15 |
20130211114 | Poly(Thioesters), Their Applications and Derivatives - A composition of the formulae MZAORS | 2013-08-15 |
20130211115 | PROCESS FOR THE PURIFICATION OF A FATTY ACID ALKYL ESTER BY LIQUID/LIQUID EXTRACTION - The present invention relates to a process for the selective extraction of monoglycerides present in a fraction of fatty acid alkyl esters (FAAEs), comprising at least one stage of liquid-liquid extraction by means of a polar solvent (PS) comprising a light alcohol and optionally of a nonpolar solvent (NS) comprising a solvent which is immiscible with the light alcohol. | 2013-08-15 |
20130211116 | SALTS OF 5-SULFOISOPHTHALIC ACID AND METHOD OF MAKING SAME - This invention relates to methods for the production of various metal salts of 5-sulfoisophthalic acid including those where the metal cation is selected from the group consisting of silver (I), sodium, potassium, rubidium, cesium, magnesium, calcium, strontium, barium, manganese (II), iron (II), cobalt (II), nickel (II), copper (I), copper (II), zinc, yttrium, and cadmium. The methods utilize a solvent system that comprises acetic acid or water or a mixture of both. The invention also encompasses the various metal salts of 5-sulfoisophthalic acid. | 2013-08-15 |
20130211117 | ORGANOMETALLIC COMPOUND PREPARATION - A method of continuously manufacturing an organometallic compound is provided where two or more reactants are conveyed to a contacting zone of a reactor in a manner so as to maintain a laminar flow of the reactants; and causing the reactants to form the organometallic compound. | 2013-08-15 |
20130211118 | ORGANOMETALLIC COMPOUND PREPARATION - A method of continuously manufacturing organometallic compounds is provided where two or more reactants are conveyed to a reactor having a laminar flow contacting zone, a heat transfer zone, and a mixing zone having a turbulence-promoting device; and causing the reactants to form the organometallic compound. | 2013-08-15 |
20130211119 | Hydrophobic Diacrylamide Compound - A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound. | 2013-08-15 |
20130211120 | USE OF AN ACETIC ACID WASH TO PREPARE LOW-SULFATE 5-SULFOISOPHTHALIC ACID, MONO-LITHIUM SALT - There is disclosed a process for making a mono-lithium salt of 5-sulfoisophthalic acid (LiSIPA) having less than 500 ppm sulfate. The process uses a reaction mixture of water, a lithium cation producing compound, and 5-sulfoisophthalic acid. The reaction mixture is heated to reflux, cooled, filtered and washed with acetic acid to obtain a high quality LiSIPA having less than 500 ppm sulfate. Also disclosed is a high quality, non-purified reaction product containing a mono-lithium salt of 5-sulfoisophthalic acid and having less than 500 ppm sulfate. | 2013-08-15 |
20130211121 | PROCESS FOR MAKING NITRILES - Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3-pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide. The catalyst for the reaction of 1,3-butadiene with hydrogen cyanide to make 3-pentenenitrile is recycled. At least a portion of the recycled catalyst is purified by an extraction process, which separates catalyst degradation products and reaction byproduct from the catalyst. | 2013-08-15 |
20130211122 | PROCESS FOR MAKING NITRILES - An improved multi-reaction zone process provides for improved nitrile product quality and yield. In a first reaction zone, 1,3-butadiene is reacted with hydrogen cyanide in the presence of a catalyst to produce pentenenitriles comprising 3-pentenenitrile and 2-methyl-3-butenenitrile. In a second reaction zone, 2-methyl-3-butenenitrile, recovered from the first reaction zone, is isomerized to 3-pentenenitrile. In an optional third reaction zone, 3-pentenenitrile recovered from the first and second reaction zones is reacted with hydrogen cyanide in the presence of a catalyst and a Lewis acid to produce adiponitrile. A portion of the first catalyst is purified and recycled. Zero valent nickel is added to the purified first catalyst before it is recycled. | 2013-08-15 |
20130211123 | PROCESS FOR MAKING NITRILES - Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3-pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide. The catalyst for the reaction of 1,3-butadiene with hydrogen cyanide to make 3-pentenenitrile is recycled. At least a portion of the recycled catalyst is purified by an extraction process, which separates catalyst degradation products and reaction byproducts, such as mononitriles having 9 carbon atoms, from the catalyst. | 2013-08-15 |
20130211124 | PROCESS FOR MAKING NITRILES - Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3-pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide and by isomerizing 2-methyl-3-butenenitrile. Phenolic compounds, such as phenol and cresols, are present as a catalyst impurity or as a catalyst degradation product. Phenolic compounds are removed during the nitrile manufacturing process. | 2013-08-15 |
20130211125 | PROCESS FOR MAKING NITRILES - Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3-pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide. The 1,3-butadiene feed includes a small amount of tertiary-butylcatechol. The catalyst for the reaction of 1,3-butadiene with hydrogen cyanide to make 3-pentenenitrile is recycled. At least a portion of the recycled catalyst is purified by an extraction process. | 2013-08-15 |
20130211126 | PROCESS FOR MAKING NITRILES - Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3-pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide and by isomerizing 2-methyl-3-butenenitrile. The reaction of 1,3-butadiene with hydrogen cyanide to produce 3-pentenenitrile also produces small amounts of dinitrile compounds, including adiponitrile (ADN) and methylglutaronitrile (MGN). Methylglutaronitrile is removed to provide an adiponitrile-enriched stream, which is used in a catalyst purification step. | 2013-08-15 |
20130211127 | PROCESS FOR MAKING NITRILES - An improved multi-reaction zone process provides improved nitrile product quality and yield. In a first reaction zone, 1,3-butadiene is reacted with hydrogen cyanide in the presence of a catalyst to produce pentenenitriles comprising 3-pentenenitrile and 2-methyl-3-butenenitrile. In a second reaction zone, 2-methyl-3-butenenitrile, recovered from the first reaction zone, is isomerized to 3-pentenenitrile. In a third reaction zone, 3-pentenenitrile recovered from the first and second reaction zones is reacted with hydrogen cyanide in the presence of a catalyst and a Lewis acid to produce adiponitrile. Unwanted production and build-up of dinitriles, including methylglutaronitrile, in the first reaction zone for the hydrocyanation of 1,3-butadiene is prevented by limiting the flow of Lewis acid into the first reaction zone. | 2013-08-15 |
20130211128 | Process for the Preparation of Prostaglandin Analogues - A process for preparing a prostaglandin analogue comprising a step of converting a compound of formula (8′): | 2013-08-15 |
20130211129 | Process for Preparing Esteramide Compounds - The present invention concerns a process for preparing esteramide compounds. More particularly, the invention relates to a process for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basic compound, wherein the basic compound and the amine in gaseous form are co-added to the diester, the reaction being conducted at a temperature of 30° C. or higher. | 2013-08-15 |
20130211130 | PROCESS FOR PREPARING CARBOXAMIDINE COMPOUNDS - The present invention relates to a process of making a compound of formula (I): | 2013-08-15 |
20130211131 | Method For Producing Acyloxy Benzoic Acids - The invention relates to a method for producing acyloxy benzoic acids of the formula (I), in which R | 2013-08-15 |
20130211132 | METHOD FOR PREPARING DI-ALPHA-METHYL BENZYL ADIPATE - A method for preparing di-alpha-methyl benzyl adipate by direct esterification of adipic acid and alpha-methylbenzyl alcohol is described. The reaction can produce a high yield and can be carried out under mild conditions, in the presence of a catalyst selected from among the orthotitanates of tetra-hydrocarbyl. | 2013-08-15 |
20130211133 | "METHOD FOR PREPARING RAMALIN" - The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes. | 2013-08-15 |
20130211134 | Process And System For The Separation of Solid Carboxylic Acid Fines - In a process for the separation of solid carboxylic acid fines from mother liquor that includes such fines, the mother liquor is fed to a settlement drum at above atmospheric pressure. The mother liquor having a lower concentration of carboxylic fines than that fed to the settlement drum is then removed, wherein the mother liquor removal occurs at a point above the point at which the mother liquor containing fines is fed to the settlement drum. In a system for performing the separation process, a settlement drum has an inlet for mother liquor with carboxylic acid fines and an outlet for mother liquor having a lower concentration of carboxylic acid fines content than that of the mother liquor introduced via the inlet. The settlement drum is configured to operate at above atmospheric pressure and the outlet is located at a point in the settlement drum above the inlet. | 2013-08-15 |
20130211135 | METHODS OF MAKING L-ORNITHINE PHENYL ACETATE - Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, inter-mixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms. | 2013-08-15 |
20130211136 | COMPOSITIONS COMPRISING SHIKIMIC ACID OBTAINED FROM OIL PALM BASED MATERIALS AND METHOD OF PRODUCING THEREOF - The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP). | 2013-08-15 |
20130211137 | DIRECT ACTIVATION OF METHANE - Heteropolyacids (HPAs) can activate methane at ambient temperature (e.g., 20° C.) and atmospheric pressure, and transform methane to acetic acid, in the absence of any noble metal such as Pd). The HPAs can be, for example, those with Keggin structure: H | 2013-08-15 |
20130211138 | Removal of Contaminants from Liquid-Liquid Extraction Solvent - A method of treating a solvent in a wood processing operation is described. A first organic compound is extracted from an aqueous solution with a solvent. Then, the solvent is contacted with an alkali solution to remove a second organic compound from the solvent. For example, the first organic compound may be acetic acid and the second organic compound may be lignin. In another embodiment, a liquid-liquid extraction solvent used to extract acetic acid from an aqueous solution is rejuvenated by contacting the solvent with an alkali solution to remove a second organic compound from the solvent. The rejuvenated solvent is then recycled for further liquid-liquid extraction. | 2013-08-15 |
20130211139 | PROCESS FOR PRODUCING OPTICALLY ACTIVE BETA-AMINO ALDEHYDE COMPOUND - The invention relates to a method of producing optically active β-aminoaldehyde compound (3) by reacting imine compound (1-1) or sulfone compound (1-2) with aldehyde compound (2) in the presence of an optically active pyrrolidine compound. | 2013-08-15 |
20130211140 | METERING RING - The present invention relates to an apparatus for metering flowable media or gases, and to the use thereof. | 2013-08-15 |
20130211141 | MONITORING OF THE STOICHIOMETRIC RATIO IN THE REACTION OF NITROAROMATICS WITH HYDROGEN - The present invention relates to a continuous process for preparing at least one aromatic amine by hydrogenation of at least one nitroaromatic by means of hydrogen, where a liquid phase comprising at least the aromatic amine and a gas phase comprising at least hydrogen are present, in the presence of a catalyst suspended in the liquid phase at a temperature of from 50 to 250° C. and a pressure of from 5 to 50 bar, wherein the pressure in the reactor is kept essentially constant by continuous adaptation of the amount of hydrogen fed to the reactor, the total amount of hydrogen fed to the reactor is monitored and the introduction of the at least one nitroaromatic is interrupted if the hydrogen uptake in the reactor is not at least 50 mol % of the amount of hydrogen required for stoichiometric reaction of the at least one nitroaromatic to form the at least one aromatic amine. | 2013-08-15 |
20130211142 | HALOGENATED DIETHYLTOLUENEDIAMINES - Disclosed are halogenated diethyltoluenediamines of formula | 2013-08-15 |
20130211143 | Method and an Apparatus for Producing Organic Solvents and Alcohols by Microbes - The present invention relates to a cell retaining matrix (CRB) for producing solvents and alcohols and an apparatus comprising said bio-column. The invention also relates to the method for producing solvents and alcohols by using said cell retaining matrix (CRB). Said cell retaining biomatrix (CRB cellulosic fibers, selected from the group consisting wood cellulosic fibers, pulp cellulosic fibers, vegetable cellulosic fibers, such as mechanical pulp, dissolving pulp, lignocellulosic fibers, and cellulosic fibers originated from vegetable peels, and at microbes, which have been immobilized into said cellulosic fibers, and which can save their biological activity in cell retaining biomatrix (CRB). | 2013-08-15 |
20130211144 | MULTI-STAGE REACTION FOR MITIGATINGTHE PRESENCE OF UNWANTED CATIONS - Methods for producing organic products that may include the steps of providing a feed stream comprising a first organic salt and a second organic salt to a reactor; reacting the feed stream at a first temperature to convert at least some of the first organic salt to the organic products, wherein reacting the feed stream results in a first product stream comprising the organic products and second organic salt; separating at least a portion of the organic products from the first product stream resulting in a first reduced product stream comprising second organic salt; and reacting the first reduced product stream at a second temperature to convert the second organic salt to a second organic products. | 2013-08-15 |
20130211145 | Protected Aldehydes For Use As Intermediates In Chemical Syntheses, And Processes For Their Preparation - A para-methoxy protected benzaldehyde useful in preparation of treprostinil, and of formula: (Formula (1)) is prepared by subjecting to Claisen re-arrangement a substituted benzaldehyde of formula (1a): (Formula (Ia)) to form the m-hydroxy-substituted benzaldehyde of formula (1b): (Formula (Ib)) and then reacting compound (1b) with a p-methoxybenzyl (PMB) compound to form a PMB-substituted benzaldehyde of formula (1). | 2013-08-15 |
20130211146 | CATALYTIC CONVERSION OF ALCOHOLS AND ALDEHYDES - The invention provides a process for preparing higher alcohols and/or aldehydes and also mixtures thereof by catalytic reaction of ethanol, the reaction taking place in the presence of at least one catalyst, the catalyst comprising an activated-carbon substrate which is provided with at least one metal, and more particularly has at least one metal dope. | 2013-08-15 |
20130211147 | LOW PRESSURE DIMETHYL ETHER SYNTHESIS CATALYST - A catalyst and process for synthesis of dimethyl ether from synthesis gas are disclosed. The catalyst and process allow dimethyl ether synthesis at low pressures (below 20 bars) at a conversion rate close to the expected equilibrium rate. The catalyst is a combination of a methanol synthesis catalyst and a methanol dehydration catalyst, wherein the dehydration catalyst is a mixture of dehydration agents which allow optimum production of dimethyl ether. | 2013-08-15 |
20130211148 | Catalyst And Method For The Direct Synthesis Of Dimethyl Ether From Synthesis Gas - Catalysts and methods for their manufacture and use for the synthesis of dimethyl ether from syngas are disclosed. The catalysts comprise ZnO, CuO, ZrO | 2013-08-15 |
20130211149 | Process for the preparation of hydroquinones - The invention relates to a process for the preparation of a hydroquinone compound of formula (I) | 2013-08-15 |
20130211150 | Chemisorption of Ethyl Acetate During Hydrogenation of Acetic Acid to Ethanol - A hydrogenation catalyst and process using the catalyst for converting a mixture comprising acetic acid and ethyl acetate to ethanol at a first temperature, and the catalyst desorbs ethyl acetate, in the absence of hydrogen, at a second temperature that is greater than the first temperature. The catalyst has a suitable chemisorption of ethyl acetate at the first temperature in the absence of hydrogen. In one embodiment, the first temperature ranges from 125° C. to 350° C. and the second temperature ranges from 300° C. to 600° C. The catalyst comprises one or more active metals or oxide thereof on a support that comprises tungsten or an oxide thereof. The one or more active metals are selected from the group consisting of cobalt, copper, gold, iron, nickel, palladium, platinum, iridium, osmium, rhenium, rhodium, ruthenium, tin, zinc, lanthanum, cerium, manganese, chromium, vanadium, and molybdenum. | 2013-08-15 |
20130211151 | Process for Producing Ethanol Using Acetic Acid from a Carbonylation Process - The present invention relates to a process for the production of ethanol. The process comprises the step of hydrogenating acetic acid in a hydrogenation reactor in the presence of a catalyst and under conditions effective to form a crude ethanol product. The acetic acid may be obtained from a carbonylation system. The process further comprises the step of separating, in at least one column, at least a portion of the crude ethanol product into a distillate and a residue. The distillate comprises ethanol, water, and ethyl acetate. The residue comprises acetic acid and water. The process preferably comprises the step of directing at least a portion of the residue to at least one column of the carbonylation system. The process further comprises the step of separating the first distillate to form a purified ethanol product. | 2013-08-15 |
20130211152 | Ethanol Manufacturing Process Over Catalyst with Cesium and Support Comprising Tungsten or Oxides Thereof - The present invention relates to a process for producing product comprising ethanol which comprises contacting a feedstock comprising acetic acid and hydrogen in a reaction zone at hydrogenation conditions with a catalyst composition comprising at least one active metal that may include a Group VIII metal and tin and from 0.01 to 0.5 wt. % cesium on a support comprising tungsten or oxides thereof. | 2013-08-15 |
20130211153 | System for Alcohol Production - The invention concerns a system and process for alcohol production. | 2013-08-15 |
20130211154 | PROCESS FOR THE PRODUCTION OF HCFC-1233zd - A process for the manufacture of 1-chloro-3,3,3-trifluoropropene (HCFC-1233zd) at commercial scale from the reaction of HCC-240 and HF is disclosed. In one embodiment, HCC-240fa and HF are fed to a reactor operating at high pressure. Several different reactor designs useful in this process include; a stirred-tank reactor (batch and/or continuous flow); a plug flow reactor; a static mixer used as a reactor; at least one of the above reactors operating at high pressure; optionally combined with a distillation column running at a lower pressure; and combinations of the above; and/or with a distillation column. The resulting product stream consisting of 1233zd, HCl, HF, and other byproducts is partially condensed to recover HF by phase separation. The recovered HF phase is recycled to the reactor. The HCl is scrubbed from the vapor stream and recovered as an aqueous solution. The remaining organic components including the desired HCFC-1233zd are scrubbed, dried and distilled to meet commercial product specifications. | 2013-08-15 |
20130211155 | PROCESS FOR MAKING TETRAFLUOROPROPENE - The present invention describes a process for making CF | 2013-08-15 |
20130211156 | PROCESS FOR 1,3,3,3-TETRAFLUOROPROPENE - The present invention provides a simple three step process for the production of 1,3,3,3-tetrafluoropropene (HFO-1234ze). In the first step, carbon tetrachloride is added to vinyl fluoride to afford the compound CCl | 2013-08-15 |
20130211157 | Cyclohexylbenzene Compositions - In a process for producing phenol and cyclohexanone, a feed comprising cyclohexylbenzene is oxidized to produce an oxidation reaction product comprising cyclohexyl-1-phenyl-1-hydroperoxide. At least a portion of the oxidation reaction product is then cleaved to produce a cleavage reaction product comprising phenol, cyclohexanone, and at least one contaminant At least a portion of the cleavage reaction product is contacted with an acidic material to convert at least a portion of the at least one contaminant to a converted contaminant and thereby produce a modified reaction product. The composition comprising cyclohexylbenzene may have at least 10 wt % of cyclohexylbenzene; 1 wppm to 1 wt % of bicyclohexane; 1 wppm to 1 wt % of biphenyl; and 1 wppm to 2 wt % of methylcyclopentylbenzene, wherein the wt % s and wppms are based upon total weight of the composition. | 2013-08-15 |
20130211158 | HIGH SURFACE AREA CARBON AND PROCESS FOR ITS PRODUCTION - Activated carbon materials and methods of producing and using activated carbon materials are provided. In particular, biomass-derived activated carbon materials and processes of producing the activated carbon materials with prespecified surface areas and pore size distributions are provided. Activated carbon materials with preselected high specific surface areas, porosities, sub-nm (<1 nm) pore volumes, and supra-nm (1-5 nm) pore volumes may be achieved by controlling the degree of carbon consumption and metallic potassium intercalation into the carbon lattice during the activation process. | 2013-08-15 |
20130211159 | METHOD FOR DEGASSING A STORAGE TANK FOR LIQUID PRODUCTS CONTAINING VOLATILE ORGANIC COMPOUNDS, IN PARTICULAR PETROLEUM PRODUCTS - Method for degassing a storage tank for liquid products containing volatile organic compounds or VOC, in particular petroleum products, comprising a step a) of introducing an aqueous mixture comprising substances able to interact chemically and/or physically with the VOC in the gaseous state inside the tank, which is kept closed, so as to encourage them to pass from the gaseous phase to the liquid phase, and to remain in the liquid phase. Such introduction step being protracted so as to reduce the concentration of the VOC to a predetermined value functional to having an acceptable explosive limit. | 2013-08-15 |
20130211160 | SYSTEMS AND METHODS FOR OFF-SHORE ENERGY PRODUCTION - The invention is directed to aquatic systems and methods for off-shore energy production, particularly to systems and methods for generating large amounts of methane via anaerobic digestion, purifying the methane produced, and sequestering environmentally deleterious by-products such as carbon dioxide. The energy production systems contain one or more flexible, inflatable containers supported by water, at least one of which is an anaerobic digester containing bacteria which can produce energy sources such as methane or hydrogen from aquatic plants or animals. Off-shore energy production facilities supported by water bodies offer many advantages over land-based digesters, including the use of large, available open water bodies as an alternative means of support and the potential for locating the facilities at sites that already contain, or can be easily modified to generate, sufficient amounts of feedstock onsite. In addition, the containers of the invention can be large enough to provide adequate amounts of energy to support off-shore activities and relatively easy to manufacture and ship to remote production sites. The systems can also be readily adapted to sequester carbon dioxide or replenish feedstocks growing nutrients on site. | 2013-08-15 |
20130211161 | PROCESS FOR CONVERTING A HEAVY FEED USING A CATALYTIC CRACKING UNIT AND A STEP FOR SELECTIVE HYDROGENATION OF THE GASOLINE OBTAINED FROM CATALYTIC CRACKING - The present invention describes a process for converting a heavy feed which is flexible for the production of propylene, gasoline and middle distillate. | 2013-08-15 |
20130211162 | METHOD AND SYSTEM FOR PURIFYING AN ETHYLENE-CONTAINING GAS STREAM - A two catalyst system is described having separate catalyst beds for the selective conversion of acetylene to ethylene which reduces the concentration of acetylene, dienes, O2, and NOx is disclosed. An ethylene containing gas stream, such as an off-gas stream from a refinery catalytic cracking unit used in the production of fuels and gas oils, is treated by first contacting the gas stream with a silver catalyst supported on a metal oxide and subsequently contacting the gas stream with a ruthenium catalyst supported on metal oxide. The two catalysts are contained within contiguous continuous reactors or reactor compartments. | 2013-08-15 |
20130211163 | PROCESS FOR SELECTIVELY HYDROGENATING A GASOLINE CUT IN THE PRESENCE OF A SUPPORTED SULPHIDE CATALYST PREPARED USING AT LEAST ONE CYCLIC OLIGOSACCHARIDE - Selective hydrogenation of a gasoline cut containing polyunsaturated hydrocarbons containing at least 2 carbon atoms per molecule and having an end point of 250° C. or less, by bringing said gasoline cut into contact with at least one catalyst the active phase of which comprises at least one metal from group VIII and at least one metal from group VIB deposited on a support. | 2013-08-15 |
20130211164 | Alkylation Process - The present invention provides an improved process for producing an alkylated aromatic compound from an at least partially untreated alkylatable aromatic compound having catalyst poisons and an alkylating agent, wherein said alkylatable aromatic compound stream is treated to reduce catalyst poisons with a treatment composition having a surface area/surface volume ratio of greater than or equal to 30 in | 2013-08-15 |
20130211165 | Hydrocarbon Pyrolysis Method - Disclosed is a pyrolysis reaction process. The process can be advantageously accomplished using a pyrolysis reactor that has a primary reaction zone comprised of bed packing having multiple passages through the bed packing and a secondary reaction zone having an open flow arrangement. The process includes a step of injecting a pyrolysis feed comprising a first hydrocarbon into the primary reaction zone to produce a primary pyrolysis product containing unsaturated hydrocarbon. A reactive feed comprising a second hydrocarbon is injected into the secondary reaction zone to mix with the primary pyrolysis product and produce a secondary pyrolysis product. | 2013-08-15 |
20130211166 | PROCESS FOR PREPARING BUTADIENE AND/OR BUTENES FROM N-BUTANE - The process for preparing butadiene from n-butane comprises the steps of
| 2013-08-15 |
20130211167 | CATALYTIC CONVERSION METHOD FOR IMPROVING PRODUCT DISTRIBUTION - The present invention relates to a catalytic conversion process for improving the product distribution, characterized in that a feedstock oil of good quality is contacted with a hot regenerated catalyst having a lower activity in a reactor to carry out a cracking reaction, the reaction product is separated from the spent catalyst to be regenerated, then the reaction product is fed into a separation system, and the spent catalyst to be regenerated is stripped, regenerated and recycled in the process. The isobutene content in the liquefied petroleum gas (LPG) produced by the process is increased by a factor of more than 30%, and the olefin content in the gasoline composition may be increased to more than 30 wt. %. The product distribution is optimized, and the yields of dry gas and coke are decreased, so as to sufficiently utilize the petroleum resources. | 2013-08-15 |
20130211168 | CATALYTIC COMPOSITION AND PROCESS FOR OLIGOMERIZATION OF OLEFINS USING SAID CATALYTIC COMPOSITION - The invention relates to a catalytic composition that comprises at least one precursor of iron or cobalt, at least one organic ligand, and an activating agent that consists of at least one derivative of aluminum and at least one organic compound having at least one alcohol group and/or at least one amine group, and in which the molar ratio between the aluminum and the alcohol and/or amine group number present in said organic compound of said activating agent is preferably greater than or equal to 1. The invention also relates to a process for oligomerization of olefins using said catalytic composition. | 2013-08-15 |
20130211169 | Hydrocarbon Conversion Process - The invention relates to a process for converting hydrocarbons into unsaturated products such as acetylene and/or ethylene. The invention also relates to converting acetylene to olefins such as ethylene and/or propylene, to polymerizing the olefins, and to equipment useful for these processes. | 2013-08-15 |
20130211170 | ISOPROPYL ALCOHOL-PRODUCING BACTERIUM HAVING IMPROVED PRODUCTIVITY BY GNTR DESTRUCTION - An isopropyl alcohol-producing | 2013-08-15 |
20130211171 | METHOD FOR REMOVING ACID GASES FROM HYDROCARBON-COMPRISING FLUIDS - In a method for removing acid gases from hydrocarbon-comprising fluids, (a) a carbon dioxide-rich acid gas stream is separated off from the fluid by scrubbing with a liquid absorbent, (b) the fluid is contacted with a solid adsorbent for removing sulfur-comprising acid gases, and (c) the loaded solid adsorbent is regenerated by contacting with at least one purge gas under regeneration conditions. A carbon dioxide-rich acid gas stream separated off in step (a) is used as purge gas. | 2013-08-15 |
20130211172 | METHOD FOR PARTIALLY DECONTAMINATING RADIOACTIVE WASTE - Methods for partially decontaminating radioactive waste wherein the waste is first mixed, or brought in contact, with at least one corrosive medium. Activation energy is then supplied to the corrosive medium, so that at least a portion of the radionuclide present in the waste is converted into at least one gaseous reaction product, or is dissolved, by hydrogen or hydrogen ions, oxygen or oxygen ions, and/or halogen (for example chlorine) or halogen ions from the corrosive medium. The aim is that of decontaminating a | 2013-08-15 |
20130211173 | METHODS AND APPARATUS FOR CONTAINING HAZARDOUS MATERIAL - Methods and apparatus for containing a hazardous material according to various aspects of the present invention operate in conjunction with a container having two compartments. The first compartment is configured to contain the hazardous material within a non-rigid bladder and the second compartment contains a hazard control material within a two-piece container configured to enclose the first compartment. The container may further comprise a wall separating the first compartment from the second compartment that is configured to open upon occurrence of a trigger event to release the hazard control material. | 2013-08-15 |
20130211174 | Gamma Radiation Apparatus for Remediation of Organic Compounds in Waste Slurries - A process for the remediation and treatment of tar sands tailings, all process waters and waste slurries comprises irradiating the waste slurry with gamma radiation to degrade naphthenic acids in the waste slurry and reduce the potential of environmental harm caused by waste slurry discharge and accelerate to natural or assisted rehabilitation of this material into the natural environment. | 2013-08-15 |