31st week of 2012 patent applcation highlights part 45 |
Patent application number | Title | Published |
20120196734 | FOLDING DEVICE AND FOLDING METHOD - A folding device is provided that includes a platen member, a folding member, a folding member mechanism and a horizontal side moving mechanism. A folding object is put on the platen member while an extended part thereof is extended from at least one of right and left sides of the platen member. The folding member mechanism moves the folding member towards the platen member for folding the extended part of the folding object. The horizontal slide moving mechanism slides and moves at least one of the platen member and the folding member for separating the platen member and the folding member along a horizontal direction. | 2012-08-02 |
20120196735 | PHASE-SEPARATED SODA-LIME-SILICA GLASS - The invention relates to a glass having SiO | 2012-08-02 |
20120196736 | Aluminum-Containing Waterglass Solutions - The invention relates to a process for preparing clear aqueous solutions of silicates, remaining stable at 20° C. on storage for at least 6 months, containing 20% to 40% by weight SiO | 2012-08-02 |
20120196737 | Shaded Zirconia Ceramics - The invention relates to compositions based on Ce-stabilized ZrO | 2012-08-02 |
20120196738 | METHOD FOR PRODUCING ELECTRODE CATALYST FOR FUEL CELL - The present invention provides a method for producing an electrode catalyst for a fuel cell, comprising the steps of: mixing conductive particles loaded with catalyst metal fine particles with an organic compound; and heat treating the mixture formed in the mixing step under an inert gas atmosphere, so as to carbonize the organic compound. According to the present invention, the size increase of catalyst metal fine particles, which lowers catalytic activity, can be suppressed. | 2012-08-02 |
20120196739 | METHOD FOR PRODUCING DDR ZEOLITE - Disclosed is a method for producing a DDR zeolite, which can be carried out using materials that are less harmful to the environment. The method for producing a DDR zeolite has a short hydrothermal synthesis time and does not require continuous agitation of the raw material solution. Specifically disclosed is a method for producing a DDR zeolite, which comprises: a raw material solution preparation step in which a raw material solution that contains 1-adamantaneamine, silica (SiO | 2012-08-02 |
20120196740 | Process for Producing Optically Pure beta-Lactones from Aldehydes and Compositions Produced Thereby - Bi-functional cobalt-containing catalysts useful for making stereo specific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure β-lactones from aldehydes and ketene are described. Precursors, intermediates, compositions, and particular features of the use if the compositions, such as high enantiomeric selectivity, high yield and low mole percent of catalyst useful are provided. | 2012-08-02 |
20120196741 | Thin Film Ink Catalyst - In one embodiment, a catalyst ink includes a number of catalytic particles each including a particle base which supports a 2-dimension (2D) extensive catalyst film, the 2D extensive catalyst film including at least one precious metal. The 2D extensive catalyst film may contact an exterior surface of the particle base. The 2D extensive catalyst film may contact an interior surface of the particle base. In another embodiment, the particle base has a base dimension that is 50 to 10,000 times greater than a thickness of the 2D extensive catalyst film. In certain instances, the particle base has a base dimension that is 100 to 5,000 times greater than a thickness of the 2D extensive catalyst film. | 2012-08-02 |
20120196742 | PRECIPITATED FILM AND FABRICATING METHOD THEREOF - A precipitated film and the fabricating method thereof are disclosed. The precipitated film includes a supporting layer having columnar crystals, and a functional layer formed on the supporting layer and having granular crystals. The precipitated film is fabricated by phase-changing one of two aqueous solutions, which are able to react with each other to form a solid precipitate inherently, into solid-state and then reacting with the other aqueous solution to form the precipitated film by a precipitation reaction. | 2012-08-02 |
20120196743 | OXIDATION CATALYST, REDUCTION CATALYST, AND CATALYST FOR PURGING EXHAUST GAS - An oxidation catalyst containing a carbon material prepared by calcining a transition metal compound and a nitrogen-containing organic substance, or a transition metal compound, a nitrogen-containing organic substance, and a carbon compound not containing nitrogen, the oxidation catalyst oxidizing CO and/or a hydrocarbon. | 2012-08-02 |
20120196744 | PROCESS FOR PRODUCING COMPOSITE OXIDE CATALYST - A process for producing a composite oxide catalyst which includes a step of preparing an aqueous slurry containing at least iron and antimony and composed of a liquid phase and a solid phase, a step of drying the aqueous slurry to obtain a dried material, and a step of calcining the obtained dried material, wherein of the precipitated particles having a particle size of not less than 1 μm but less than 150 μm contained within the aqueous slurry, the proportion of precipitated particles having a particle size of not less than 1 μm but less than 10 μm is within a range from 40 to 90% by volume, and the proportion of precipitated particles having a particle size of not less than 10 μm but less than 150 μm is within a range from 10 to 60% by volume. | 2012-08-02 |
20120196745 | METHOD OF MANUFACTURING HIERARCHICAL MESOPOROUS CARBON AND CARBON OBTAINED THEREBY - A hierarchical mesoporous carbon is provided in which a total volume of mesopores of the hierarchical mesoporous carbon is 80% or greater of a total volume of pores of the hierarchical mesoporous carbon; a volume of mesopores with a average diameter greater than 20 nm and no greater than 50 nm is 3% or greater of the total volume of the pores; and a volume of mesopores with a average diameter greater than 2 nm and no greater than 10 nm is 65% or greater of the total volume of the pores. The hierarchical mesoporous carbon, which also contains macropores, has an optimized mesoporous distribution characteristic, and has an increased total volume of pores, thereby having a significantly improved catalytic activity when used as a catalyst support. When such a supported catalyst is used in a fuel cell, supply of fuel and transporting of byproducts are facilitated. | 2012-08-02 |
20120196746 | BRANCHED COPOLYMER/ANTHRANILIC DIAMIDE COMPOSITIONS FOR PROPAGULE COATING - Disclosed is an insecticidal composition comprising by weight based on total weight of composition
| 2012-08-02 |
20120196747 | COMPOSITIONS AND METHODS OF INHIBITING PLANT BIOLOGY - A method of inhibiting the rate of at least one biological process in a seed or plant is disclosed. The method comprises contacting a part of a seed, a plant, or the locus thereof with a composition of matter, the composition of matter comprising an agriculturally acceptable complex mixture of dissolved organic material substantially devoid of one or more metal ions essential for the at least one biological process in the seed or plant. A composition of matter is also disclosed comprising a mixture of compounds derived from natural organic matter (NOM) that is substantially devoid of metal ions. | 2012-08-02 |
20120196748 | PESTICIDAL COMPOSITION - The present invention relates to an agrochemical composition suitable for seed treatment comprising a herbicide which is laterally mobile in the soil, and an adhesive polymer. | 2012-08-02 |
20120196749 | Cyclosporin Derivatives - A cyclosporin derivative of general Formula (I) or a pharmaceutically compatible salt thereof, which have a pharmaceutical effectiveness, for example in the case of chronic inflammatory diseases. The cyclosporin derivatives are preferably free from a peptide section capable of passing through the membrane of a biological cell. | 2012-08-02 |
20120196750 | PYRIDAZINONE COMPOUND AND USE THEREOF - A pyridazinone compound represented by the formula (I) | 2012-08-02 |
20120196751 | ANTHRAQUINONE CONTAINING PREPARATIONS/LIGNIN FORMULATIONS - Provided is a formulation comprising (a) a preparation comprising one or more anthraquinone derivatives having activity against plant pests and (b) a lignin. Also provided is a method for obtaining the formulation and for using the formulation to modulate phytopathogenic, fungal and/or bacterial infection and/or plant pest infestation. | 2012-08-02 |
20120196752 | UNDERLYING LAYER OF ALIGNMENT FILM FOR OXIDE SUPERCONDUCTING CONDUCTOR AND METHOD OF FORMING SAME, AND DEVICE FOR FORMING SAME - A method of forming an underlying layer of an alignment film for an oxide superconducting conductor, includes arranging two or more kinds of targets along a lengthwise direction of a base material so as to face a surface of the base material; simultaneously irradiating an ion beam on surfaces of the two or more kinds of targets to deposit constituent particles of the targets on the surface of the base material in the order of the arrangement of the two or more kinds of targets; and forming a laminate in which two or more kinds of thin films are repeatedly laminated on the surface of the base material by passing the base material through a deposition region of the constituent particles a plurality of times so that the constituent particles of the targets are repeatedly deposited on the surface of the base material at each passage. | 2012-08-02 |
20120196753 | COOLING SYSTEM AND METHOD FOR COOLING SUPERCONDUCTING MAGNET DEVICES - A cooling system and method for cooling superconducting magnet coils are provided. One magnet system for a superconducting magnet device includes a cooling system having at least one coil support shell, a plurality of superconducting magnet coils supported by the at least one coil support shell and a plurality of cooling tubes thermally coupled to the at least one coil support shell. The magnet system also includes a cryorefrigerator system fluidly coupled with the plurality of cooling tubes forming a closed circulation cooling system. | 2012-08-02 |
20120196754 | NON-INVASIVE DETERMINATION OF FETAL INHERITANCE OF PARENTAL HAPLOTYPES AT THE GENOME-WIDE SCALE - The present invention provides a method, device and a computer program for haplotyping single cells, such that a sample taken from a pregnant female, without directly sampling the fetus, provides the ability to non-invasively determine the fetal genome. The method can be performed by determining the parental and inherited haplotypes, or can be performed merely on the basis of the mother's genetic information, obtained preferably in a blood or serum sample. The novel device allows for sequence analysis of single chromosomes from a single cell, preferably by partitioning single chromosomes from a metaphase cell into long, thin channels where a sequence analysis can be performed. | 2012-08-02 |
20120196755 | COMPOSITIONS AND METHODS FOR GENOME-WIDE MAPPING OF CHROMOSOME BREAKAGE AND OTHER METHODS FOR MANIPULATION OF CELLS EMBEDDED IN MATRIX - The embodiments described herein provide for compositions and methods for genome-wide mapping of chromosome fragile sites in cellular chromosomal material. More specifically, a method of genome-wide detection of regions of single-stranded DNA and double stranded breaks in DNA, the hallmarks of chromosome fragility, comprises embedding a plurality of cells in a matrix and subsequently directly labeling the single-stranded DNA and/or double stranded DNA breaks; eluting or isolating the labeled chromosomal material from the matrix; and performing analysis to detect the location of the chromosome fragility sites. | 2012-08-02 |
20120196756 | DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION - The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer. | 2012-08-02 |
20120196757 | PROGRAMMABLE OLIGONUCLEOTIDE SYNTHESIS - The invention relates to methods and devices for preparing synthetic nucleic acids. | 2012-08-02 |
20120196758 | METHOD FOR NUCLEOTIDE DETECTION - A method of inhibiting light-induced degradation of nucleic acids includes irradiating a portion of the nucleic acids in the presence of a detection solution comprising a polyphenolic compound. A method of detecting a nucleic acid having a fluorescent tag includes irradiating at least a portion of the nucleic acid with light of a suitable wavelength to induce a fluorescence emission and detecting the fluorescence emission. Optionally, the polyphenolic compound is gallic acid, a lower alkyl ester thereof, or mixtures thereof. A kit includes one or more nucleotides, an enzyme capable of catalyzing incorporation of the nucleotides into a nucleic acid strand and a polyphenolic compound suitable for preparing a detection solution. | 2012-08-02 |
20120196759 | TEMPERATURE REGULATION OF MEASUREMENT ARRAYS - A system for regulating a temperature of a measurement array is disclosed. The system includes a measurement array including a plurality of sensors, wherein the plurality of sensors are integrated onto an integrated circuit die. The system includes a thermal sensor integrated onto the integrated circuit die, wherein the thermal sensor senses a temperature associated with the plurality of sensors. The system further includes a heat pump coupled to the integrated circuit die, wherein the heat pump is controlled by a feedback control circuit including the thermal sensor. | 2012-08-02 |
20120196760 | METHODS AND COMPOSITIONS FOR IDENTIFYING MODULATORS OF ANTI-TETHERIN ACTIVITY TO INHIBIT PROPAGATION OF VIRUSES - The present invention provides protein constructs for detection of interaction between Tetherin and ant-Tetherin molecules. The constructs include a Tetherin sequence or a portion of a Tetherin sequence that is sufficient for cell-surface localization, and a sequence providing a detectable signal. The invention further provides methods of using such constructs to screen for substances that modulate the Tetherin-inhibiting properties of anti-Tetherins. Methods of screening for anti-viral agents, including anti-HIV agents, are provided. | 2012-08-02 |
20120196761 | DIAGNOSIS OF IN SITU AND INVASIVE BREAST CANCER - The disclosure includes the use of gene expression profiles, or patterns, with clinical relevance to breast cancer. In particular, the disclosure provides the identities of genes that are expressed in correlation with the presence of breast cancer, the grade of breast cancer, and the type of breast cancer. The disclosed methods assist in the detection and identification of breast cancer in a patient and so helps determine treatment and clinical outcome, and so prognosis, for the patient. The gene expression levels, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used detect the presence of in situ or invasive breast cancer. | 2012-08-02 |
20120196762 | METHOD AND APPARATUS FOR DISCOVERY, DEVELOPMENT AND CLINICAL APPLICATION OF MULTIPLEX ASSAYS BASED ON PATTERNS OF CELLULAR RESPONSE - A method for deriving a multiplex cell response assay (MCRA), the method comprising:
| 2012-08-02 |
20120196763 | ANTIFUNGAL TARGET - A method of identifying an antifungal agent which targets a PPTB protein of a fungus comprising determining whether a candidate compound binds to or inhibits a PPTB protein, wherein binding or inhibition indicates that the candidate sub-stance is an antifungal agent. | 2012-08-02 |
20120196764 | SALIVARY TRANSCRIPTOMIC AND MICROBIAL BIOMARKERS FOR PANCREATIC CANCER - The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing pancreatic cancer and distinguishing between pancreatic cancer and chronic pancreatitis. The present invention additionally provides kits that find use in the practice of the methods of the invention. | 2012-08-02 |
20120196765 | METHOD FOR DETECTION OR ANALYSIS OF TARGET SEQUENCE IN GENOMIC DNA - A method of detecting or analyzing a target sequence in a genomic DNA by using a capture probe immobilized on a solid carrier includes: bringing the target nucleic acid into contact with a first query probe that has a sequence complementary to a portion of the target sequence or to a sequence adjacent to the portion and a second query probe that has a sequence complementary to another portion of the target sequence or to a sequence adjacent to the another portion and that has a recognition sequence complementary to a portion of the capture probe; acquiring a ligated molecule by ligating the first query probe and the second query probe that are hybridized to the target nucleic acid; bringing the ligated molecule into contact with the capture probe on the solid carrier and then capturing the ligated molecule on the solid carrier by hybridizing the capture probe with the recognition sequence in the ligated molecule; and detecting the captured ligated molecule. | 2012-08-02 |
20120196766 | Therapeutic Use of Farnesyltransferase Inhibitors and Methods of Monitoring the Efficacy Thereof - The therapeutic use of farnesyltransferase inhibitors (e.g., tipifarnib) for the treatment of sepsis is described. Methods useful to monitor the effectiveness of such treatment are also described. | 2012-08-02 |
20120196767 | MICROARRAY BASED SAMPLE DETECTION SYSTEM - A microarray assembly for detection of a target molecule is disclosed. The microarray assemblies comprise an array chamber having a microarray located therein and features that facilitate liquid movement within the array chamber. Also disclosed are methods for making the microarray assembly using rollable films and methods for detecting microarray spots using an internal control fluorophore in the array spot. | 2012-08-02 |
20120196768 | METHOD FOR PREPARING aRNA AND METHOD FOR ANALYSIS OF GENE EXPRESSION - A method for preparing aRNA to be used for gene expression analysis from an RNA sample extracted from a tissue or cell(s) fixed with a fixative includes an amplification step of the RNA sample by reverse transcription and in vitro transcription, the ratio of aminoallyl uridine 5′-triphosphate (AA-UTP) in a nucleotide reagent used in the in vitro transcription is not less than 5 mol % and less than 25 mol % with respect to the total of uridine 5′-triphosphate (UTP) and AA-UTP. | 2012-08-02 |
20120196769 | Methods of repairing tandemly repeated DNA sequences and extending cell life-span using nuclear transfer - This invention relates to methods for rejuvenating normal somatic cells and for making normal somatic cells of a different type having the same genotype as a normal somatic cell of interest. These cells have particular application in cell and tissue transplantation. Also encompassed are methods of re-cloning cloned animals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent, e.g., that are “hyper-young.” These animals should be healthier and possess desirable properties relative to their cloned parent. Also included are methods for activating endogenous telomerase, EPC-1 activity, and or the ALT pathway and/or extending the life-span of a normal somatic cell, and other genes associated with cell aging and proliferation capacity. | 2012-08-02 |
20120196770 | GEL-ENCAPSULATED MICROCOLONY SCREENING - Provided herein are methods and compositions useful for detecting the production of industrially useful compounds (e.g., isoprenoids, polyketides, and fatty acids) in a cell, for example, a microbial cell genetically modified to produce one or more such compounds. In some embodiments, the methods comprise encapsulating the cell in a hydrogel particle, and detecting the compound within the hydrogel particle. | 2012-08-02 |
20120196771 | HIGH SPEED, HIGH FIDELITY, HIGH SENSITIVITY NUCLEIC ACID DETECTION - Methods, compositions, and kits for nucleic acid detection. | 2012-08-02 |
20120196772 | COMPOUND SYNTHESIS METHOD, MICROARRAY, ACID-TRANSFER COMPOSITION, AND BIOCHIP COMPOSITION - A compound synthesis method includes bonding a first compound to a substrate to form a first film. A second film is formed on the first film using an acid-transfer composition including (A) a polymer that includes a structural unit shown by a following formula (1) and a structural unit shown by a following formula (2), (B) a photoacid generator shown by a following formula (3), and (C) a sensitizer shown by a following formula (4). The second film is exposed to remove the protecting group from the first compound under an exposed are of the second film. An acid generated in the exposed area of the second film is transferred to the first film. The second film after being exposed is removed. A second compound is bonded to the first compound from which the protecting group has been removed. | 2012-08-02 |
20120196773 | Methods For Monitoring Multiple Gene Expression - The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing | 2012-08-02 |
20120196774 | SYSTEMS, DEVICES, AND METHODS FOR ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES - Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like. | 2012-08-02 |
20120196775 | EMISSION INTENSITY MEASURING DEVICE - An emission intensity measuring device includes a light receiving unit that is disposed opposed to a biochip having a plurality of compartments in which a sample is housed, and includes a plurality of light receiving elements that are arranged, and a determining section that determines a weighting rate of each of the light receiving elements based on a noise characteristic of the light receiving element, acquired in advance. The emission intensity measuring device further includes a multiplying section that multiplies the output of each of the light receiving elements by the weighting rate to calculate a weighted output of each of the light receiving elements, and an adding section that adds the weighted outputs of the light receiving elements opposed to a respective one of the compartments. | 2012-08-02 |
20120196776 | Oil Field Treatment Fluids - A method of servicing a well is disclosed. The method comprises mixing ingredients to form a well servicing fluid. The ingredients comprise (i) at least one surfactant chosen from alcohol ethoxylates, C | 2012-08-02 |
20120196777 | Variable Pressure Weighting Material Particles - Variable pressure weighting material particles that include a hollow, elastically deformable particle which itself comprises a wall and an internal fluid at a pressure of 15 psi to about 100 psi. The variable pressure weighting material particles generally include a hollow, elastically deformable particle that compresses during introduction into a subterranean formation and returns to substantially the same shape when removed from the subterranean formation. | 2012-08-02 |
20120196778 | Lubricating Composition Containing an Antiwear Agent - The invention provides a lubricating composition containing (a) an oil of lubricating viscosity, (b) a phosphite having at least one hydrocarbyl group that has 4 or more carbon atoms, and (c) a compound derived from a hydroxy-carboxylic acid. The invention further relates to the use of the lubricating composition in an internal combustion engine. | 2012-08-02 |
20120196779 | Cutting Fluids with Improved Performance - The cutting of semi-conducting crystals with a wire saw is facilitated with a cutting fluid comprising a polyalkylene glycol neutralized with an un-neutralized or partially neutralized polymeric acid that has a molecular weight of 500 to 1,000,000 and contains more than three acid groups per molecule. | 2012-08-02 |
20120196780 | Lubricant compositions for vacuum pumps - The invention pertains to a lubricant composition comprising:
| 2012-08-02 |
20120196781 | GREASE COMPOSITION FOR BEARING OF WIND POWER GENERATOR - The invention provides a grease composition for bearings used in wind power generators, containing a base oil which has a kinematic viscosity of 10 to 70 mm | 2012-08-02 |
20120196782 | Rock Drill Oil - Provided is a lubricating oil composition suitable for use in rotary pneumatic and reciprocating tools, comprising a Fischer-Tropsch base oil, a friction modifier based on synthetic ester and a sulfurized extreme pressure agent. The present lubricating oil composition has superior wear, friction and extreme pressure characteristics. | 2012-08-02 |
20120196783 | PERSONAL CLEANSING SYSTEMS EXHIBITING LOW EYE IRRITATION POTENTIAL - An ethylene oxide-free, dioxane-free, and formaldehyde-free personal care concentrate composition free of ethoxylated components which is non-irritating to eyes comprising water, sodium alkyl sulfate, propanediol, and a synthetic amphoteric surfactant selected from the group consisting of cocamidopropyl hydroxysultaine and cocamidopropyl betaine is disclosed. This composition is especially suitable for baby shampoos which are not irritating. In some embodiments the composition is free of formaldehyde. | 2012-08-02 |
20120196784 | DETERGENT FORMULATIONS FOR MACHINE DISHWASHING COMPRISING HYDROPHILICALLY MODIFIED POLYCARBOXYLATES - A phosphate-free detergent formulation for machine dishwashing is provided. The formulation contains as main components: copolymers of a monoethylenically unsaturated monocarboxylic acid and/or of a salt thereof, and an alkoxylated, monoethylenically unsaturated monomer, wherein the copolymer has a mean molecular weight M | 2012-08-02 |
20120196785 | TRIAZINE DERIVATIVE DYE TRANSFER INHIBITORS, WASHING PRODUCTS CONTAINING THE SAME AND USES THEREFOR - Washing products comprising a dye transfer inhibitor selected from triazine derivatives of the general formulae T(NH—Ar(SO | 2012-08-02 |
20120196786 | CLEANING APPARATUS AND METHOD UTILIZING SUBLIMATION OF NANOFABRICATED PARTICLES - A cleaning apparatus comprises a container configured to hold an article to be cleaned, a cleaning solvent dispenser configured to supply a cleaning solvent to the container, an energy generator configured to provide thermal energy to an interior of the container; and a control device in communication with the energy generator and configured to select thermal energy sufficient to sublimate the particles. The cleaning solvent comprises a solvent and nanofabricated particles dispersed therein. The control device controls the energy generator to provide thermal energy to the cleaning solvent in container in which the article is submerged in order to cause sublimation of the particles. | 2012-08-02 |
20120196787 | SHAPED SOLID CLEANING COMPOSITION - The invention relates to a shaped solid cleaning composition, especially in bar format, which utilises the detergency properties of new materials which are more efficient, relatively inexpensive and are environmentally friendly alternatives to conventional soaps or synthetic surfactants. The present invention provides for a shaped solid cleaning composition which comprises a specific amount of structuring agent and a specific amount of a treated particle. The precursor of the treated particle is an asymmetric 1:1 or 2:1: clay particle having alternating tetrahedral and octahedral sheets terminating with a tetrahedral sheet at a first external surface plane and an octahedral sheet at a second external surface plane. Either or both of said external surfaces is attached with a fatty acid or derivative thereof. | 2012-08-02 |
20120196788 | LOW VOC COMPOSITION FOR RELEASING ADHERENT DEPOSITS FROM A NONPOROUS SURFACE - Compositions and methods for release of adherent deposits from nonporous surfaces and substrates are provided. The compositions are low volatile organic compound (low VOC) compositions, solutions or mixtures that can be applied in a form that clings to the underlying surface while it is working. Adherent deposits removed using the compositions include grease and oil, and printers ink. The compositions may be used on any nonporous surface or substrate including metals, ceramics and plastics, without harming the surface or substrate. The composition may contain a thixotropic agent to act as an anti-shearing agent. | 2012-08-02 |
20120196789 | PEPTIDE BASED PEROXIDASE INHIBITORS AND METHODS OF USING SAME - The present invention provides peptide-based peroxidase inhibitors having the formula AA | 2012-08-02 |
20120196790 | CYCLIC DEPSIPEPTIDES - The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase. | 2012-08-02 |
20120196791 | COMBINATION THERAPIES USING ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS - Methods for treating a bacterial infection in a mammal in need thereof, and compositions related thereto, are disclosed, the methods comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound and a second antibacterial agent. | 2012-08-02 |
20120196792 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS - The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient. | 2012-08-02 |
20120196793 | BIOMARKERS FOR IAP INHIBITOR COMPOUNDS - A method to predict which patients will respond to a IAP inhibiting compound comprising administering an IAP inhibitor compound to a patient/and measuring IL1B, Lymphotoxin alpha (LTa), TWEAK, LIGHT, Fas, TNF alpha or TRAIL levels. | 2012-08-02 |
20120196794 | Combinations of Hepatitis C Virus Inhibitors - The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising such compounds, and methods for treating hepatitis C using such combinations. | 2012-08-02 |
20120196795 | NOVEL EXENDIN VARIANT AND CONJUGATE THEREOF - The invention provides a novel Exendin variant and the Exendin variant conjugate conjugating polymer thereon, the pharmaceutical composition comprising them and use of them for treating diseases such as reducing blood glucose, treating diabetes, especially Type II diabetes. The invention also provides the use of Exendin conjugate for lowering body weight. | 2012-08-02 |
20120196796 | AMYLIN FAMILY PEPTIDES AND METHODS FOR MAKING AND USING THEM - The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk. | 2012-08-02 |
20120196797 | Methods and Compositions for the Treatment of Gastrointestinal Disorders - Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor. | 2012-08-02 |
20120196798 | GLP-1 ANALOGUES AND THEIR PHARMACEUTICAL SALTS AND USES - This invention discloses GLP-1 analogues and their pharmaceutical salts, wherein the GLP-1 analogue comprises an amino acid sequence of general formula (I), wherein Lys represents a modified lysine with a lipophilic acid. The GLP-1 analogues provided by this invention have the function of human GLP-1, and a longer half-life in vivo compared with the human GLP-1. Uses of such compounds and compositions include treating non-insulin-dependent diabetes, insulin-dependent diabetes, and obesity. | 2012-08-02 |
20120196799 | Amylin Family Peptides and Methods for Making and Using Them - Methods for treating obesity are disclosed which comprise administration of a therapeutically effective amount of an amylin or an amylin agonist alone or in conjunction with another obesity relief agent. Additionally, methods for reducing insulin-induced weight gain are disclosed which comprise administration of a therapeutically effective amount of an amylin or an amylin agonist. | 2012-08-02 |
20120196800 | STABLE NON-AQUEOUS LIQUID PHARMACEUTICAL COMPOSITIONS COMPRISING AN INSULIN - The invention describes a non-aqueous liquid pharmaceutical composition comprising at least one lipid and at least one insulin. Also described is a method of producing a pharmaceutical composition comprising a lipid and a method of purifying a lipid, a cosolvent, a surfactant or a pharmaceutical composition comprising a lipid. | 2012-08-02 |
20120196801 | Wound-healing, anti-ambustial, regenerating, and anti-viral pharmaceutical formula for local administration - The main active ingredients of the formula are papaverin, bendazol, and insulin. The drug may be produced in soft, liquid medicinal form or as an aerosol. | 2012-08-02 |
20120196802 | MODIFIED EXENDINS AND USES THEREOF - The present invention discloses a modified exendin or pharmaceutically acceptable salts thereof, wherein the modified exendin comprises an amino acid sequence having at least 90% sequence identity to SEQ ID No. 17 and the amino acid sequence has a higher stability than the non-modified exendin of SEQ ID No. 4. These compounds are useful in treating type 2 diabetes as GLP-1 receptor agonists. | 2012-08-02 |
20120196803 | FUSION PROTEINS FOR DELIVERY OF GDNF AND BDNF TO THE CENTRAL NERVOUS SYSTEM - The present invention relates to a compound that includes a peptide vector, such as angiopep-2 which acts as a carrier across the blood-brain barrier, linked to glial-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), or a related molecule, such as an analog or a fragment thereof. The compounds of the invention may be used to treat any disease where increased neuronal survival or growth is desired, e.g., neurodegenerative diseases, such as Parkinson's disease or amyotrophic lateral sclerosis. Other diseases can be treated using the compounds include schizophrenia and depression. | 2012-08-02 |
20120196804 | GLUCAGON ANALOGS EXHIBITING PHYSIOLOGICAL SOLUBILITY AND STABILITY - Modified glucagon peptides are disclosed having improved solubility and stability, wherein the native glucagon peptide has been modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, or both. | 2012-08-02 |
20120196805 | COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS - The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development. | 2012-08-02 |
20120196806 | ANTICOAGULANT AND COMPOSITION FOR PREVENTING THROMBUS CONTAINING POLY-GAMMA-GLUTAMIC ACID - The present invention relates to an anticoagulant and a composition for preventing thrombus formation, which contain poly-gamma-glutamic acid (PGA) as an active ingredient. The inventive PGA is a water-soluble, anionic, biodegradable and edible amino acid polymer material, which has an anticoagulant effect of preventing thrombi from being accumulated in blood vessels, shows an excellent sustained-release effect and is harmless to the human body. Thus, it is useful as a high-value-added anticoagulant and a food or beverage composition for preventing thrombus formation. | 2012-08-02 |
20120196807 | KIDNEY-TARGETING DRUG DELIVERY AGENT COMPRISING RECOMBINANT GELATIN - An object of the present invention is to provide a kidney-targeting drug delivery agent which is composed of bioabsorbable materials, transiently accumulates in a kidney and particularly kidney functional units such as tubular epithelial cells for a short period of time, and does not remain in the kidney for a prolonged time after accumulation. The present invention provides a kidney-targeting drug delivery agent which comprises a gelatin-like protein. | 2012-08-02 |
20120196808 | Peptidic Vasopressin Receptor Agonists - The present application relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification. | 2012-08-02 |
20120196809 | USE OF ICAM-1 FOR PREVENTION OR TREATMENT OF NEUROLOGICAL DISEASES - The present invention relates to a pharmaceutical composition for the prevention or treatment of neurological disorders, comprising an ICAM-1 (intercellular adhesion molecule-1) protein, or a fragment or a variant thereof as an active ingredient, which can increase the expression of neprilysin to remove amyloid-beta (Aβ), a cause of dementia, and is thus useful in preventing or treating a neurological disease including Alzheimer's disease. | 2012-08-02 |
20120196810 | ANIONIC POLYMER, POLYION COMPLEX AND TERNARY POLYMER COMPOSITE USING ANIONIC POLYMER, AND PHARMACEUTICAL COMPOSITION - There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: | 2012-08-02 |
20120196811 | VETERINARY PHARMACEUTICAL COMPOSITION AND METHOD (ALTERNATIVES) FOR THE PROPHYLAXIS AND TREATMENT OF DISEASES OF THE GASTROINTESTINAL TRACT AND INTOXICATIONS OF DIVERSE ETIOLOGY IN ANIMALS - A veterinary pharmaceutical composition for treating diseases of the gastrointestinal tract and intoxications of diverse etiology in animals comprises, as the active component, hydrolyzed lignin and a prebiotic from the following group: lactulose, fructooligo-saccharides, galacto-saccharides and inulin, and is in a form suitable for use in the composition of a mixture with combined feed, with a lignin content of from 30 to 95% by mass, in the form of powder of granules. The method for the prophylaxis and treatment of intoxication of diverse etiology, including mycotoxicoses, in animals, including birds, envisages that the animal will receive the above-mentioned veterinary pharmaceutical composition mixed with feed in a dosage of from 2 to 4.5 kg of the preparation per ton of combined feed, proportional to the content of mycotoxins in the combined feed. The method for the prophylaxis and treatment of diseases of the gastrointestinal tract, including dyspepsia, gastroenteritis, enteritis, colitis, hepatitis, and hepato-dystrophy, including in a toxic form, in animals, including cattle and pigs, envisages that the animal will receive the veterinary pharmaceutical composition according to claim | 2012-08-02 |
20120196812 | PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF - The invention relates to the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia using a SGLT-2 inhibitor. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions. | 2012-08-02 |
20120196813 | GLYCOSIDE DERIVATIVE AND USES THEREOF - This invention relates to compounds represented by formula (I): | 2012-08-02 |
20120196814 | (R)-1-(4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4- ]TRIAZIN-6-YLOXY)PROPAN-2-OL METABOLITES - The present invention is directed to metabolites of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol, the compound of formula (I), pharmaceutical compositions thereof, and to methods of using the metabolites and the pharmaceutical compositions in the treatment of cancer. | 2012-08-02 |
20120196815 | Withanolide Isolated from Physalis longifolia and Analogs and Methods of Use Thereof - The present invention features novel withanolides, as well as analogs and salts thereof, for use in the treatment of proliferative disease, cardiovascular disease, neurodegenerative disease and inflammatory disease. | 2012-08-02 |
20120196816 | METHOD FOR ENHANCING NUTRIENT ABSORPTION WITH ASTRAGALOSIDES - The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound. | 2012-08-02 |
20120196817 | METHOD FOR ENHANCING NUTRIENT ABSORPTION WITH ASTRAGALOSIDES - The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound. | 2012-08-02 |
20120196818 | METHOD FOR PREPARING POLYPHENOL EXTRACTS FROM SPINACH LEAVES - A method for preparing a concentrated spinach extract in a liquid or dry form and having a polyphenol titer greater than or equal to 50% is described. The method includes a step of purifying a raw spinach extract in a liquid form using a liquid-liquid extraction technique with a food oil. | 2012-08-02 |
20120196819 | ANIMAL TREATMENTS - Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of a immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said compositon dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal. | 2012-08-02 |
20120196820 | INSESCTICIDAL COMPOSITION AND PROCESSES RELATED THERETO - Insecticidal compositions comprising:
| 2012-08-02 |
20120196821 | METHOD AND FORMULATION FOR THE CONTROL OF PARASITES - An aqueous micellar formulation for localised topical application to an animal for the concurrent control of internal and external parasites in and on the animal, the formulation comprising a water-miscible co-solvent, a fatty alcohol alkoxylate, a macrocyclic lactone and water. Also described is a method for the concurrent control of internal and external parasites in and on an animal, the method comprising administering to the animal by localised topical application an aqueous micellar formulation comprising a macrocyclic lactone. | 2012-08-02 |
20120196822 | Diyne Compositions - A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum anti-fungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting. | 2012-08-02 |
20120196823 | PHARMACEUTICAL COMPOSITIONS OF CYTIDINE ANALOGS AND METHODS OF USE THEREOF - The present disclosure provides pharmaceutical compositions comprising cytidine analogs for parenteral administration. Also provided are methods of preparing the compositions and methods of treating diseases and disorders using the compositions provided herein. | 2012-08-02 |
20120196824 | THERAPEUTIC AGENT FOR CEREBRAL INFARCTION - The invention provides a therapeutic drug for ischemic stroke. The therapeutic drug has the formula (I) | 2012-08-02 |
20120196825 | COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM - The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair. | 2012-08-02 |
20120196826 | METHODS FOR TRANSDIFFERENTIATION OF BODY TISSUES - The invention relates to methods for transdifferentiation of body tissues which can be used to generate specific cell types needed for regenerating organs or body parts, following cellular degeneration, injury or amputation. The present invention also describes the use of tissue transdifferentiation for treating cancer and autoimmune disease. | 2012-08-02 |
20120196827 | METHYLATION MARKERS FOR EARLY DETECTION AND PROGNOSIS OF COLON CANCERS - Using a combination of analytic methods epigenetic silencing of markers in cancer have been determined. The cancers are generally those of the gastrointestinal tract including but not limited to esophageal, head and neck, gastric, pancreas, liver, and colon. The genes can be used for the early detection of cancer or can be used to identify adenomas that will likely progress to carcinomas. Therapeutic regimens based on the epigenetic silenced genes can be chosen and/or monitored. Kits for evaluating epigenetic silencing of these genes can be used for detection and monitoring. | 2012-08-02 |
20120196828 | SENSITIZATION OF CANCER CELLS TO TREATMENT - The present application provides methods for the treatment of cancer, comprising administering substantially non-anticoagulant 2-O, 3-O desulfated heparin to patients suffering from cancer that is, or can become resistant to, cancer treatment, such as chemotherapy, targeted cancer therapy, or radiation therapy. The compositions can be administered to sensitize, or to reverse resistance to, cancer treatment, and can be administered alone or in combination with cancer treatment to subjects with solid tumors including, but not limited to, pancreatic, breast, renal, colorectal, gastric, or esophageal cancer, and subjects with hematologic malignancies, including but not limited to leukemia and lymphoma. | 2012-08-02 |
20120196829 | METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE FOR THE PREVENTION AND TREATMENT OF DISEASE CONDITIONS - The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ω-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids. | 2012-08-02 |
20120196831 | COMPOSITION FOR TREATING AND PREVENTING OBESITY INCLUDING HIGH WATER-SOLUBLE 2-HYDROXYPROPYL-betaCYCLODEXTRIN AS EFFECTIVE COMPONENT - There is provided a composition for preventing and treating obesity including high water-soluble β-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble β-cyclodextrin derivatives, especially, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner. | 2012-08-02 |
20120196832 | SUBSTITUTED POLYALKOXYSILOXANE COMPOSITIONS AND METHODS OF USE - Linear polydialkoxysiloxanes with 2-8 polymeric units have been reacted with alcohols by a transetherification reaction to provide hydrophilic and water soluble silicone products. The glycerol substituted siloxanes in particular are effective in topically treating skin lesions such as radiation burns. Compositions including the substituted polydialkoxysiloxane products inhibit biofilm formation when used as coatings on hard surfaces. | 2012-08-02 |
20120196833 | PHOSPHORUS CONTAINING QUINAZOLINE COMPOUNDS AND METHODS OF USE - Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts. | 2012-08-02 |
20120196834 | Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs - Disclosed are highly stable compositions having outstanding storage stability and/or demonstrating exceptional resistance to aqueous solution degradation, the composition including an orally active nucleotide analogue or an orally active nucleotide analogue prodrug, which is orally bioavailable, such as adefovir dipivoxil and tenofovir disoproxil. For example, when a composition of the invention is stored for 1 month or for 18 months at 25° C. and 60% relative humidity, its orally active nucleotide analogue or orally active nucleotide analogue prodrug degrades to provide a composition containing no more than 0.2% or no more than 0.7% by weight of a less orally bioavailable impurity, respectively. Also disclosed are a container/closure package system including the composition and a package insert and methods of manufacturing the composition and treating a patient for a disease or condition, for example, a viral disease or cancer, with the use of the composition. | 2012-08-02 |