31st week of 2013 patent applcation highlights part 53 |
Patent application number | Title | Published |
20130197166 | PROCESS FOR PRODUCTION OF HIGHLY POLYMERIZED AROMATIC POLYCARBONATE RESIN - A method for highly polymerizing an aromatic polycarbonate resin, which enables the increase in molecular weight of the aromatic polycarbonate resin satisfactorily while keeping good quality of the resin. An aromatic polycarbonate is linked to an aliphatic diol compound having a boiling point of 240° C. or higher (preferably in an amount of 0.01 to 1.0 mole per mole of the total amount of the terminal of the aromatic polycarbonate) through a transesterification reaction in the presence of a transesterification catalyst under reduced pressure conditions (preferably at a reduced pressure ranging from 13 kPaA (100 torr) to 0.01 kPaA (0.01 torr)), thereby increasing the molecular weight of the resulting molecule. The weight average molecular weight (Mw) of the aromatic polycarbonate after the transesterification reaction can be increased preferably by 5,000 or more compared to that of the aromatic polycarbonate before the transesterification reaction. | 2013-08-01 |
20130197167 | POLY(PHENYLENE ETHER)-POLYSILOXANE COMPOSITION AND METHOD - A composition is prepared by oxidative copolymerization of specific amounts of 2,6-dimethylphenol, 2,3,6-trimethylphenol, and a hydroxyaryl-terminated polysiloxane. The composition exhibits an increased heat resistance relative to a corresponding composition prepared by copolymerizing 2,6-dimethylphenol and hydroxyaryl-terminated polysiloxane, without 2,3,6-trimethylphenol. The composition is useful as a flame-retardant additive in polymer compositions that require high heat resistance. | 2013-08-01 |
20130197168 | Polymerization Process to Make Low Density Polyethylene - A high pressure polymerization process to form an ethylene-based polymer comprises the steps of: A. Injecting a first feed comprising a chain transfer agent system (CTA system) and ethylene into a first autoclave reactor zone operating at polymerization conditions to produce a first zone reaction product, the CTA system of the first reactor zone having a transfer activity Z1; and B. (1) Transferring at least part of the first zone reaction product to a second reactor zone selected from a second autoclave reactor zone or a tubular reactor zone and operating at polymerization conditions, and, optionally, (2) freshly injecting, a second feed into the second reactor zone to produce a second zone reaction product, with the proviso that at least one of the first reactor zone product and the freshly injected feed comprises a CTA system with a transfer activity of Z2; and with the proviso that the ratio of Z1:Z2 is greater than 1. | 2013-08-01 |
20130197169 | METHOD FOR FEEDING AN ANTISTATIC COMPOUND TO A POLYMERIZATION REACTOR - A method for feeding an antistatic compound to a polymerization reactor, the method comprising the steps of: a) dispersing, under mixing conditions, a catalyst powder and an antistatic compound in a liquid medium, so as to form a suspension of the catalyst powder and of the antistatic compound in the liquid medium; b) transferring the obtained suspension to a polymerization reactor. | 2013-08-01 |
20130197170 | CONTINUOUS PROCESS FOR PREPARING POLYFLUOROACRYLATE PARTICLES - The present invention is directed to a continuous process for preparing a crosslinked polymer comprising a fluoro group. | 2013-08-01 |
20130197171 | METHOD FOR FEEDING AN ANTISTATIC COMPOUND TO A POLYMERIZATION REACTOR - A method for feeding an antistatic compound to a polymerization reactor comprising the steps of: a) dispersing, under mixing conditions, a catalyst powder and an antistatic compound in an oil, so as to form a suspension of catalyst powder and antistatic compound in said oil; b) successively adding, under mixing conditions, a molten thickening agent to said suspension from step a), while maintaining said suspension at a temperature such that said thickening agent solidifies on contact with said suspension; c) transferring the product obtained from b) to a polymerization reactor. | 2013-08-01 |
20130197172 | MAGNESIUM DICHLORIDE-ALCOHOL ADDUCTS AND CATALYST COMPONENTS OBTAINED THEREFROM - Adducts comprising a MgCl | 2013-08-01 |
20130197173 | CATALYST SYSTEM FOR THE POLYMERIZATION OF OLEFINS - A catalyst system comprising the product obtained by contacting (a) a solid catalyst component containing Mg, Ti, halogen and at least an electron donor compound selected from diolesters of a specific formula (b) an alkylaluminum cocatalyst and (c) an ester of formula R′OOC—(CR″ | 2013-08-01 |
20130197174 | COPOLYMER AND METHOD OF MANUFACTURING THE SAME - Disclosed is a method of manufacturing a copolymer of a conjugated diene compound and an olefin other than the conjugated diene compound, where a conjugated diene compound and an olefin other than the conjugated diene compound is copolymerized in the presence of a polymerization catalyst composition containing components: (A) a rare earth element compound or a reactant of the rare earth element compound and a Lewis base; and (B) at least one selected from a group consisting of an ionic compound (B-1) composed of a non-coordinating anion and a cation, an aluminoxane (B-2), and at least one kind of halogen compound (B-3) selected from among a Lewis acid, a complex compound of a metal halide and a Lewis base, and an organic compound containing active halogen (when containing at least one of (B-1) and (B-3), the polymerization catalyst composition further contains component (C): an organometallic compound). | 2013-08-01 |
20130197175 | MANUFACTURING METHOD OF (METH) ACRYLIC POLYMER - In a method for polymerizing a (meth)acrylic monomer by living radical polymerization in the presence of a transition metal complex catalyst, the combined use of a multidentate amine (A), a base (B) and a reducing agent (C) makes it possible to achieve a rapid polymerization reaction and high monomer conversion rate and obtain a polymer having a narrow molecular weight distribution when 5-30 ppm by weight of copper atoms and a mole amount of 7 mmol % or less of multidentate amine (A) are used, each based on the total amount of (meth)acrylic monomer introduced. | 2013-08-01 |
20130197176 | SILICONE (METH)ACRYLAMIDE MONOMER, POLYMER, OPHTHALMIC LENS, AND CONTACT LENS - The present invention relates to a silicone (meth)acrylamide monomer, and this silicone (meth)acrylamide monomer is particularly suitable for use in contact lenses, intraocular lenses, artificial cornea, and the like. | 2013-08-01 |
20130197177 | NOVEL CATIONIC THICKENERS, FREE OF OIL AND SURFACTANTS, METHOD FOR PREPARING SAME AND COMPOSITION CONTAINING SAME - Polyelectrolyte resulting from polymerization, for 100 mol %, of: a) a molar ratio ≧50% and ≦99% of monomer units originating from at least one cationic monomer; b) a molar ratio >1% and ≦50% of monomer units originating from at least one monomer including a fully or partially salified free weak acid function; c) optionally a molar ratio >0 mol % and ≦5 mol % of monomer units originating from at least one monomer of formula A-C(═O)—O—[(CH | 2013-08-01 |
20130197178 | CRYSTALLINE 1H-1,2,3-TRIAZOL-5-YLIDENES - The present invention provides novel and stable crystalline 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of making 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of using 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes in catalytic reactions. | 2013-08-01 |
20130197179 | COPOLYMER OF A CONJUGATED DIENE COMPOUND AND A NON-CONJUGATED OLEFIN, RUBBER COMPOSITION, CROSSLINKED RUBBER COMPOSITION, AND TIRE - Provided is a copolymer of a conjugated diene compound and a non-conjugated olefin, the copolymer being a random copolymer including randomly arranged monomer units of the conjugated diene compound and of the non-conjugated olefin, in which the non-conjugated olefin is preferably an acyclic olefin, the non-conjugated olefin preferably has 2 to 10 carbon atoms, and specific examples of the non-conjugated olefin preferably include ethylene, propylene, and 1-butene. | 2013-08-01 |
20130197180 | Enhanced Catalyst Performance for Production of Vinyl Terminated Propylene and Ethylene/Propylene Macromers - This invention relates to a transition metal catalyst compound represented by the structure: | 2013-08-01 |
20130197181 | SILICONE RESIN WITH IMPROVED BARRIER PROPERTIES - The moisture and gas barrier properties of an organopolysiloxane having at least two substituents which are able to undergo crosslinking reactions per molecule shall be improved. This is achieved by providing an organopolysiloxane wherein at least 10 mol % of all substituents are represented by formula (1) | 2013-08-01 |
20130197182 | DIOL, AND POLYCARBONATE RESIN OR POLYESTER RESIN - A diol from which a resin material having high processability and a high refractive index can be manufactured, a polycarbonate resin and a polyester resin which is a polymer of the diol, and a molded article and an optical element formed of the polymer. The diol is represented by the general formula (1) shown below; the polycarbonate resin and the polyester resin are polymers thereof; and the molded article and the optical element are formed of the polymers, | 2013-08-01 |
20130197183 | Process for Producing a Lactic Acid-Amine Complex - A process for the production of a complex of lactic acid and either ammonia or an amine, comprising reacting one or more saccharides with barium hydroxide to produce a first reaction mixture comprising barium lactate, and contacting at least part of the first reaction mixture with ammonia or an amine and with carbon dioxide, or with the carbonate and/or bicarbonate salt of ammonia or an amine, to produce a second reaction mixture comprising said complex and barium carbonate. | 2013-08-01 |
20130197184 | PROCESS FOR PREPARING ARAMID COPOLYMER - The invention concerns processes for forming a polymer comprising residues of 2-(4-amino phenyl)-5(6)amino phenyl benzimidazole (DAPBI), paraphenylene diamine, and terephthaloyl dichloride, comprising the steps of: (a) forming a slurry of DAPBI and paraphenylene diamine in a solvent system comprising an organic solvent and an inorganic salt; and (b) adding a stoichiometric amount of terephthaloyl dichloride to the slurry in a single addition and allowing the formation of the polymer. | 2013-08-01 |
20130197185 | ARAMID COPOLYMER - The invention concerns polymer comprising residues of 2-(4-amino phenyl)-5 (6) amino phenyl benzimidazole (DAPBI), paraphenylene diamine (PPD), and terephthaloyl dichloride, made by a process comprising the steps of: (a) forming a slurry of b mole percent DAPBI and y mole percent PPD in a solvent system comprising organic solvent and c weight percent of an inorganic salt, wherein the inorganic salt is present in an amount of at least 5 weight percent of the organic solvent, DAPBI and PPD being present in an amount sufficient for providing a polymer solution having a weight percent solids of 12 percent or greater on a polymer basis; and (b) contacting the slurry of step a) with a stoichiometric amount of terephthaloyl dichloride to form a product comprising the polymer; wherein the sum of y+b is 100 and the product of b×c is 225 or greater. | 2013-08-01 |
20130197186 | PROCESS FOR PRODUCTION OF POLY(LACTIC ACID)-TYPE RESIN, AND POLY(LACTIC ACID)-TYPE PREPOLYMER - A method of producing a poly(lactic acid) resin includes carrying out direct polycondensation using lactic acid as a main raw material to prepare a crystallized prepolymer having a weight average molecular weight of 5,000 to 25,000, an enthalpy of fusion ΔHm of 50 to 65 J/g and an acid value A mol/ton satisfying (1) below: | 2013-08-01 |
20130197187 | Rosin Esters for Non-Woven Applications, Methods of Making and Using and Products Therefrom - Rosin esters having suitable color, color stability and/or odor to make them useful for non-woven applications, to non-woven products made from and/or comprising rosin esters, and to methods of making and using such rosin esters and products. | 2013-08-01 |
20130197188 | USE OF URODILATIN FOR PREPARING A MEDICAMENT FOR THE TREATMENT OF CARDIOVASCULAR, RENAL, PULMONARY AND NEURONAL SYNDROMES WHILE AVOIDING A REBOUND - Use of urodilatin for preparing a medicament for the treatment of cardiovascular, renal, pulmonary and neuronal syndromes while avoiding a rebound, wherein said medicament for the delivery of urodilatin is suitable in a first quantity for a first period of at least 48 hours, followed by delivery over a second period of at least 12 hours with successive reduction of said first quantity continuously or gradually to 0 ng/kg/min. | 2013-08-01 |
20130197189 | Method For Synthesizing A Cyclic Multivalent Peptide Using A Thiol-Mediated Reaction - A method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydrl group on natural cysteine amino acids to participate in the thiol-mediated reactions. | 2013-08-01 |
20130197190 | METHOD FOR PRODUCING SURFACTIN AND SALT THEREOF - The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent, | 2013-08-01 |
20130197191 | Binding Proteins That Bind to Human FGFR1c, Human Beta-Klotho and Both Human FGFR1c and Human Beta-Klotho - Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided. | 2013-08-01 |
20130197192 | Method and Composition for Crystallizing G Protein-Coupled Receptors - Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR. | 2013-08-01 |
20130197193 | METHOD FOR PRODUCING POROUS SILK FIBROIN MATERIAL - A method for producing a porous silk fibroin material, containing steps of: freezing a silk fibroin solution containing a silk fibroin aqueous solution having an aliphatic carboxylic acid added thereto; and then melting the frozen solution, thereby providing a porous material. A method for producing a porous silk fibroin material having excellent mechanical characteristics may be provided. | 2013-08-01 |
20130197194 | SPIDER SILK BASED MATRIX - A silk fiber based matrix composition comprising spider silk that can be biodegradable, from the spider species | 2013-08-01 |
20130197195 | Covalent Immobilization of Molecules Comprising an Amino Group - There is provided a method for covalent immobilization of at least one molecule comprising at least one amino group, said method comprising the sequential steps of: a) providing a surface comprising —SH groups, b) oxidizing the surface comprising —SH groups using redox reactions in the presence of noble metal ions, and c) contacting the surface with at least one molecule comprising at least one amino group to obtain a covalent binding of the at least one molecule to the surface, wherein said at least one amino group is involved in obtaining said covalent bond. The immobilized molecules are immobilized via stable covalent bonds. The method is more versatile since it can be performed as a one step method. All reaction steps are performed in aqueous solution. All steps can be performed at room temperature. The chemicals used are less expensive and less toxic compared to the prior art. | 2013-08-01 |
20130197196 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 2013-08-01 |
20130197197 | Chromatographic Method For Purifying FC-Containing Proteins - The present invention relates to methods of depleting impurities, in particular host cell proteins (HCP) and DNA from cell culture supernatants by means of protein A chromatography using a novel washing buffer. | 2013-08-01 |
20130197198 | Removal Of High Molecular Weight Aggregates Using Hydroxyapatite Chromatography - This invention relates to the application of hydroxyapatite chromatography to the purification of at least one antibody from a preparation containing high molecular weight aggregates. Further, this invention relates to an integration of ceramic hydroxyapatite chromatography into a combination chromatographic protocol for the removal of high molecular weight aggregates from an antibody preparation. | 2013-08-01 |
20130197199 | ANTIBODY AGAINST HUMAN PROSTAGLANDIN E2 RECEPTOR EP4 - It is an object of the present invention to provide an antibody that binds to a human PGE | 2013-08-01 |
20130197200 | METHODS OF REDUCING LEVEL OF ONE OF MORE IMPURITIES IN A SAMPLE DURING PROTEIN PURIFICATION - The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product. | 2013-08-01 |
20130197201 | ANTIBODY LIBRARIES - The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. | 2013-08-01 |
20130197202 | ANTI-CD80 ANTIBODY - The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies. | 2013-08-01 |
20130197203 | Modified Polysaccharides for Conjugate Vaccines - The present invention relates to methods of manufacture of immunogenic glycoconjugates, in particular for use in pharmaceutical compositions for inducing a therapeutic immune response in a subject. The immunogenic glycoconjugates of the invention comprise one or more oligosaccharides or polysaccharides that are conjugated to one or more carrier proteins via an active aldehyde group. Accordingly, the invention provides methods of making (i) unsaturated microbial N-acyl derivative oligosaccharides or polysaccharides; (ii) novel conjugates of unsaturated N-acyl derivatives; and (iii) glycoconjugate compositions comprising conjugate molecules of fragments of microbial unsaturated N-acyl derivatives that serve as a covalent linker to one or more proteins. The invention further encompasses the use of the immunogenic glycoconjugates pharmaceutical compositions for the prevention or treatment of an infectious disease. | 2013-08-01 |
20130197204 | NOVEL PROCESS FOR THE PREPARATION OF 9-DEOXO-9A-AZA-9A-HOMOERYTHROMYCIN A, MODIFIED IN THE C-44" OF THE CLADINOSE RING BY AN EPOXIDE GROUP - The present invention concerns a process for the preparation of the compound of formula | 2013-08-01 |
20130197205 | CHITOSAN COVALENTLY LINKED WITH SMALL MOLECULE INTEGRIN ANTAGONIST FOR TARGETED DELIVERY - The invention relates to the chitosan polymer derivatives of formula I: | 2013-08-01 |
20130197206 | METHOD FOR ACQUISITION OF SMALL RNA - The purpose of the present invention is to provide a method which is applicable to high throughput and by which small RNA can be obtained simply and efficiently. The present invention relates to a method for acquisition of small RNA, comprising contacting a carrier, in which a substance having affinity to small RNA-binding protein is immobilized on its surface, with a complex of the small RNA-binding protein and a small RNA (protein-RNA complex) to bind the protein-RNA complex to the aforementioned carrier, and releasing the small RNA by heating the carrier bound with the aforementioned protein-RNA complex at 70° C. to 100° C. in water or buffer solution of pH 3.0 to pH 8.0 | 2013-08-01 |
20130197207 | METHOD OF INHIBITING ALU RNA AND THERAPEUTIC USES THEREOF - The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compositions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest. | 2013-08-01 |
20130197208 | Parallel Preparation of High Fidelity Probes in an Array Format - The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from about 10 | 2013-08-01 |
20130197209 | MODIFIED NUCLEOTIDES - The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′) 2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H. | 2013-08-01 |
20130197210 | COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES - The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. The invention also relates to a method of preparing a composition of the present disclosure. The invention further relates to a method of delivering a therapeutic agent, using the composition of the present disclosure, where a therapeutically effective amount of a therapeutic composition of the invention may be administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. | 2013-08-01 |
20130197211 | Hydroxyalkyl starch for the treatment of cancers by reduction of tumor growth rates - The present invention relates to hydroxyalkyl starch or a pharmaceutical preparation thereof for the treatment of cancer, tumor or tumor associated diseases, especially by effectively reducing tumor growth rate and inhibiting tumor growth and wherein the hydroxyalkyl starch has a mean molecular weight (MW) above 20 and below 1300 kDa and a molar substitution (MS) in the range of from 0.1 to 1.5, wherein the alkylation may be an ethylation, propylation or butylation or mixes thereof; and wherein the alkyl may be further substituted. | 2013-08-01 |
20130197212 | Hydroxyalkyl starch for the treatment of head and neck cancers by reduction of tumor growth rates - The present invention relates to hydroxyalkyl starch or a pharmaceutical preparation thereof for the treatment of head and neck cancer, especially by effectively reducing tumor growth rate and inhibiting tumor growth and wherein the hydroxyalkyl starch has a mean molecular weight (MW) above 20 and below 1300 kDa and a molar substitution (MS) in the range of from 0.1 to 1.5, wherein the alkylation may be an ethylation, propylation or butylation or mixes thereof; and wherein the alkyl may be further substituted. | 2013-08-01 |
20130197213 | Low Temperature Chlorination of Carbohydrates - Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1′, and 6′ positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1′,6′-trichloro-4,1′,6′-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities. | 2013-08-01 |
20130197214 | Nanoparticle chains and Preparation Thereof - Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth. Nanoparticle spheres are functionalized in a controlled manner in order to enable covalent linkages. Functionalization of nanoparticles is accomplished by either ligand exchange or chemical modification of the terminal functional groups of the capping ligand. Nanoparticle chains are obtained by a variety of connectivity modes such as direct coupling, use of linker molecules, and use of linear polymeric templates. In particular, a versatile building block system is obtained through controlled monofunctionalization of nanoparticles. | 2013-08-01 |
20130197215 | Chlorination of Carbohydrates and Carbohydrate Derivatives - Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) “n” times where n≧1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields. | 2013-08-01 |
20130197216 | Device And Method For Extracting Active Principles From Natural Sources, Using A Counter-Flow Extractor Assited By A Sound Transduction System - The invention relates to a device and method for extracting active principles from natural sources, using a counter-flow extractor assisted by a sound transduction system, which allows a cavitation sound field to be applied in the zone containing the material formed by the raw material of the natural product and a solvent extraction medium. According to the invention, the device ( | 2013-08-01 |
20130197217 | 1, 2, 4-TRIAZOLONE DERIVATIVE - The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia. | 2013-08-01 |
20130197218 | NOVEL STABLE AND HIGHLY TUNABLE METATHESIS CATALYSTS - The present invention relates to catalytically active compounds of the general formula (1) that are highly tunable, as well as to a method of their preparation and their use in any type metathesis reaction. The new compounds of the present invention comprise activation sites that allow for specific catalyst design. Particularly, side chains and ligands allow efficient activity and specificity control of the catalysts of the present invention. | 2013-08-01 |
20130197219 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG - The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity. | 2013-08-01 |
20130197220 | Morpholino Nucleic Acid Derivatives - The present invention provides a useful morpholino nucleic acid derivative for synthesizing a morpholino nucleic acid oligomer. The present invention provides a compound represented by the following general formula (1) or a salt thereof. | 2013-08-01 |
20130197221 | Benzimidazole Derivatives As PI3 Kinase Inhibitors - This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3Kβ selective benzimidazoles compounds for treating cancer. | 2013-08-01 |
20130197222 | PREPARATION PROCESS OF (6R)-TETRAHYDROBIOPTERIN HYDROCHLORIDE - A preparation process of (6R)-tetrahydrobiopterin hydrochloride is provided, which comprises hydrogenating L-biopterin in the presence of a catalyst of Pt group metal in the basic substrate containing solvent, potassium hydroxide and potassium dihydrogen phosphate to obtain (6R)-tetrahydrobiopterin hydrochloride, wherein the pH value of the basic substrate is controlled by potassium hydroxide and potassium dihydrogen phosphate in the range of about 10 to about 13. | 2013-08-01 |
20130197223 | SYNTHESIS OF SUBSTITUTED SALICYLALDEHYDE DERIVATIVES - Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a). | 2013-08-01 |
20130197224 | PREPARATION METHOD OF ROSUVASTATIN CALCIUM AND ITS INTERMEDIATES - A preparation method of rosuvastatin calcium (Formula 1), which can be used for the production of medicament lowering the levels of LDL-cholesterol and triglycerides in vivo, is provided. Such preparation method is suitable for industrial production. Furthermore, the intermediate crystallines used in the preparation method are provided. | 2013-08-01 |
20130197225 | New Solid Forms of [4-(3-Fluoro-5-Trifluoromethyl-Pyridin-2-Yl)-Piperazin-1-Yl-[5-Methanesul- fonyl-2-((S)-2,2,2-Trifluoro-1-Methyl-Ethoxy)-Phenyl]Methanone - The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease. | 2013-08-01 |
20130197226 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION COMPRISING AN APOLIPOPROTEIN PEPTIDE/PHOSPHOLIPID COMPLEX - The present invention features pharmaceutical compositions and methods of using the pharmaceutical compositions for treating left ventricular diastolic dysfunction. In particular, the pharmaceutical compositions include an apolipoprotein complex comprising a lipid fraction and a protein fraction. | 2013-08-01 |
20130197227 | METHOD OF PREPARING TETRABENAZINE AND DIHYDROTETRABENAZINE - The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an Aza-Prins cyclization reaction in the presence of an oxidant and an oxidation reaction. | 2013-08-01 |
20130197228 | FUNCTIONALIZED FLUOROALKYL FLUOROPHOSPHATE SALTS - The present invention relates to functionalised fluoroalkylfluorophosphate salts, in particular as ionic liquids, to the preparation thereof and to the use thereof. | 2013-08-01 |
20130197229 | METHOD OF MAKING AZAINDAZOLE DERIVATIVES - Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds. | 2013-08-01 |
20130197230 | METHODS OF PREPARING QUINOLINE DERIVATIVES - Methods of preparing compounds of formula i(1): | 2013-08-01 |
20130197231 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION - Compounds of formula I: | 2013-08-01 |
20130197232 | PROCESS FOR THE PREPARATION OF CRYSTALLINE FORMS OF DEXLANSOPRAZOLE - The present invention relates to crystalline forms of dexlansoprazole designated as forms A and B, and their preparation. The present invention further relates to processes for the preparation of anhydrous dexlansoprazole and dexlansoprazole sesquihydrate using crystalline Forms A and B of dexlansoprazole. | 2013-08-01 |
20130197233 | SALTS OF DEXLANSOPRAZOLE AND THEIR PREPARATION - The present invention relates to the salts of dexlansoprazole in amorphous form. The present invention further relates to processes for the preparation of salts of dexlansoprazole. | 2013-08-01 |
20130197234 | METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE COMPOUND - The present invention relates to methods for producing an optically active amine compound via a highly enantioselective hydrogenation reaction of an imine compound, wherein the imine compound is hydrogenated using a ruthenium metal complex having high catalytic activity and represented by Formula (1) | 2013-08-01 |
20130197235 | Hybrid Zeolitic Imidazolate Frameworks: Controlling Framework Porosity and Functionality by a Mixed-Ligand Synthetic Approach - Metal-organic frameworks, in particular hybrid zeolitic imidazolate frameworks (ZIFs), devices having hybrid ZIFs, and methods for preparing hybrid ZIFs are disclosed herein. In some embodiments, the method includes preparing a first solution comprising a first imidazolate and a second imidazolate, preparing a second solution comprising a metal ion, and combining the first solution and the second solution to form the hybrid ZIF. | 2013-08-01 |
20130197236 | Novel Heterocyclic Alkanol Derivatives - The present invention relates to novel heterocyclic alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators. | 2013-08-01 |
20130197237 | MOLECULES HAVING COMBINABLE GROUPS - The present invention relates to nitrogenous associative molecules comprising at least one unit rendering them capable of associating with one another or with a filler, via noncovalent bonds, and comprising a function capable of reacting with a polymer containing unsaturations so as to form a covalent bond with said polymer. | 2013-08-01 |
20130197238 | FIPRONIL PRODUCTION PROCESS - An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid. | 2013-08-01 |
20130197239 | Method for the Regioselective Synthesis of 1-Alkyl-3-Haloalkyl-Pyrazole-4-Carboxylic Acid Derivatives - The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process. | 2013-08-01 |
20130197240 | PROCESS FOR PREPARING AMINOADAMANTYL CARBAMATE DERIVATIVES - Disclosed is a process for producing an aminoadamantane carbamate derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor. | 2013-08-01 |
20130197241 | CYCLIZATION METHODS - The invention provides methods for cyclizing poly-yne compounds under mild conditions to provide cyclic compounds. | 2013-08-01 |
20130197242 | PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM II OF L-MALIC ACID SALT OF SUNITINIB - The present invention relates to stable crystalline Form II of L-malic acid salt of sunitinib and its preparation. | 2013-08-01 |
20130197243 | SALTS OF 7-AMINO-3,5-DIHYDROXYHEPTANOIC ACID ESTERS - The invention relates to salts of acids with 2-propyl esters of general formula (2) The invention also relates to a method for the preparation of salts of acids with compounds of general formula (2) and to the use thereof in the preparation of atorvastatin. | 2013-08-01 |
20130197244 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES - Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme. | 2013-08-01 |
20130197245 | Organometallic Molybdenum Acetylide Dioxo Complex And Process For The Preparation Thereof - An organometallic molybdenum acetylide dioxo complex of formula (η | 2013-08-01 |
20130197246 | PROCESS FOR PREPARING EPOXYCARBOXYLIC ESTERS - Process for preparing epoxides of the formula I | 2013-08-01 |
20130197247 | GENETICALLY ENGINEERED MICROBIAL STRAINS INCLUDING PROTOTHECA LIPID PATHWAY GENES - Genetically engineered microbial, e.g., | 2013-08-01 |
20130197248 | METHODS AND PRODUCTS FOR PRODUCTION OF WAX ESTERS (U.S. NATIONAL PHASE) - The present invention relates to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing different fatty acids and specifically fatty acid ethyl esters (FAEE), the main components of biodiesel. An increased in fatty acid production, and hence in FAEE, is obtained in the first place by expressing different heterologous polypeptides in combination with the down-regulation, attenuation, deletion or over-expression of specially selected genes, wherein said genes encode enzymes involved in the fatty acids synthesizing pathway, fatty acid consuming pathways, carbohydrate biosynthesis pathways or enzyme acting as wax ester transporters or a combination thereof. The methods and products of the invention would allow large-scale production of FAEE with carbohydrates as the only externally-supplied substrate. | 2013-08-01 |
20130197249 | EXTRACTION OF IMMOBILIZED OIL USING MIXTURES OF FOOD GRADE SOLVENTS - The invention provides extraction of immobilized oil from an oil-containing feed using a food grade solvent. The food grade solvent may include ethyl acetate or ethyl lactate. The solvent may also include an ethanol co-solvent with the ethyl acetate or ethyl lactate. The solvent may be recaptured within the system and reused in the process. | 2013-08-01 |
20130197250 | ELIMINATION OF ORGANOHALO AND OXIRANE SPECIES IN CARBOXYLIC ACID ESTER STREAMS - The present technology provides a process of reducing, removing or eliminating organohalo, glycidol, and oxirane species from carboxylic acid esters streams and crude and refined triglyceride oils to provide a carboxylic acid ester stream or triglyceride oil with reduced levels or essentially free of organohalo, glycidyl or other oxirane species. The process includes adding to the carboxylic acid ester stream or triglyceride oil an amount of a carboxylate anion and a cation counterion sufficient to react with the organohalo, glycidyl and oxirane species present. | 2013-08-01 |
20130197251 | PROCESS FOR REMOVAL OF METALS FROM OILS/FATS - The invention describes process for demetallation of vegetable oils and animal fats to reduce metal content below 1 ppm to make them suitable for hydroprocessing feedstocks. The process comprises acid treatment with very low concentration of acids, utilizing synergistic effect of phosphoric acid and citric acid, followed by counter-current treatment with clay without intermediate step of water washing and treatment with ion exchange resin. | 2013-08-01 |
20130197252 | Preparation of Tri-Alkyl Gallium or Tri-Alkyl Indium Compounds - Trialkyl metal compounds, such as trialkyl gallium and indium compounds, are prepared in high yield and high purity by the addition of a trialkyl aluminum compound to a mixture prepared by adding a metal trihalide, e.g., GaCl | 2013-08-01 |
20130197253 | PHOTO-PATTERNABLE DIELECTRIC MATERIALS CURABLE TO POROUS DIELECTRIC MATERIALS, FORMULATIONS, PRECURSORS AND METHODS OF USE THEREOF - Silsesquioxane polymers that cure to porous silsesquioxane polymers, silsesquioxane polymers that cure to porous silsesquioxane polymers in negative tone photo-patternable dielectric formulations, methods of forming structures using negative tone photo-patternable dielectric formulations containing silsesquioxane polymers that cure to porous silsesquioxane polymers, structures containing porous silsesquioxane polymers and monomers and method of preparing monomers for silsesquioxane polymers that cure to porous silsesquioxane polymers. | 2013-08-01 |
20130197254 | HYDROSILICONE RESIN AND PREPARATION PROCESS THEREOF - The present invention relates to a liquid hydrosilicone resin and a preparation process thereof. The average composition of the liquid hydrosilicone resin is represented by the following formula: | 2013-08-01 |
20130197255 | METHOD OF MANUFACTURING WATER REPELLENT FILM AND THEREBY MANUFACTURED WATER REPELLENT FILM - A method of manufacturing a water repellent film includes, before a formation step of forming an organic film on a substrate using a silane coupling agent by a vapor phase deposition method under film formation conditions, a step of specifying the film formation conditions using a test substrate of a same material as the substrate used in the formation step. The film formation condition specifying step includes: specifying film formation temperature to be not lower than a temperature at which the silane coupling agent evaporates and to be lower than a temperature at which the silane coupling agent bumps; and forming an organic film of the silane coupling agent on the test substrate at the specified film formation temperature, measuring by optical microscopic observation a time at which a bead of surplus water repellent material is formed, and specifying the film formation duration to be shorter than the measured time. | 2013-08-01 |
20130197256 | METHOD FOR THE PREPARATION OF GRAPHENE - A method for the preparation of graphene is provided, which includes: (a) oxidizing a graphite material to form graphite oxide; (b) dispersing graphite oxide into water to form an aqueous suspension of graphite oxide; (c) adding a dispersing agent to the aqueous suspension of graphite oxide; and (d) adding an acidic reducing agent to the aqueous suspension of graphite oxide, wherein graphite oxide is reduced to graphene by the acidic reducing agent, and graphene is further bonded with the dispersing agent to form a graphene dispersion containing a surface-modified graphene. The present invention provides a method for the preparation of graphene using an acidic reducing agent. The obtained graphene can be homogeneously dispersed in water, an acidic solution, a basic solution, or an organic solution. | 2013-08-01 |
20130197257 | NEW PROCESS - A process for the preparation of a compound of formula (I): | 2013-08-01 |
20130197258 | PROCESS FOR PREPARING ACROLEIN FROM GLYCEROL OR GLYCERIN - The invention concerns a method for preparing acrolein from glycerol or glycerine, wherein dehydration of the glycerol or glycerine is achieved in the presence of a catalyst based on zirconium oxide and which active phase consists in at least | 2013-08-01 |
20130197259 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF - Antiproliferative compounds having a structure represented by formula (II), where n, R | 2013-08-01 |
20130197260 | PROCESSES FOR THE PREPARATION OF FESOTERODINE - The invention relates to improved process for the preparation of fesoterodine and its pharmaceutically acceptable salt, specifically fesoterodine fumarate of formula (1). The invention relates to solid state forms of a novel salt of fesoterodine and process for the preparation thereof. The invention also relates to highly pure fesoterodine fumarate substantially free of impurity X at RRT 1.37. The invention also provides solid particles of pure fesoterodine fumarate wherein 90 volume-percent of the particles (D90) have a size of higher than 200 microns. | 2013-08-01 |
20130197261 | 3,4-DIALKYLBIPHENYLDICARBOXYLIC ACID COMPOUND, 3,4-DICARBOALKOXYBIPHENYL-3', 4'-DICARBOXYLIC ACID AND CORRESPONDING ACID ANHYDRIDES, AND PROCESSES FOR PRODUCING THESE COMPOUNDS - The present invention relates to the 3,4-Dicarboalkoxybiphenyl-3′,4′-dicarboxylic acid (including the corresponding acid anhydride) represented by the general formula (1): | 2013-08-01 |
20130197262 | TRISUBSTITUTED METHYL ALCOHOLS AND THEIR POLYMERIZABLE DERIVATIVES - Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents. | 2013-08-01 |
20130197263 | 1,1-DISUBSTITUTED ETHYLENE PROCESS - New and improved processes for the production of 1,1-disubstituted ethylenes. | 2013-08-01 |
20130197264 | METHYLIDENE MALONATE PROCESS - An improved process for the production of methylidene malonates is attained by use of select iminium salt reactants. | 2013-08-01 |
20130197265 | PROCESS OF PRODUCING OXALATE BY CO GAS PHASE METHOD - The present invention relates to a process of producing oxalate by CO gas phase method for chiefly solving the technical problem of the low utilization efficiency of nitrogen oxides or nitrous acid esters in the prior art. The present invention solves the problem in a better way by using the following steps including: a gas phase stream V containing NO and methanol and oxygen enter a supergravity rotating bed reactor II and are subjected to the oxidative esterification reaction to produce an effluent VI containing methyl nitrite; a methyl nitrite effluent VII obtained from separating said effluent VI together with a CO gas II enter a coupling reactor II and is contacted with a catalyst II to react to form a dimethyl oxalate effluent VIII and a gas phase effluent IX containing NO; the resultant dimethyl oxalate effluent VIII is separated to obtain a dimethyl oxalate product I; optionally, the gas phase effluent IX containing NO is returned to the step above so as to be mixed with the gas phase stream V containing NO for being recycled. Therefore, the process is applicable to the industrial production of oxalate by CO gas phase method. | 2013-08-01 |