31st week of 2013 patent applcation highlights part 45 |
Patent application number | Title | Published |
20130196360 | MICROFLUIDIC DEVICE AND CONTROL METHOD THEREOF - A microfluidic device and control method thereof are provided. The control method of the microfluidic device includes detecting a background signal from a chamber in which a reaction product formed by combining an analyte and a marking material is not accommodated, detecting a detection signal from a chamber in which the reaction product is accommodated, and compensating for the detection signal using the background signal. | 2013-08-01 |
20130196361 | SPLIT SENSOR AND HOUSING ASSEMBLY FOR FLEXIBLE WALL - Disclosed is a sensor and housing assembly for a single-use bioreactor system, including a device for operatively associating a sensor with a flexible wall, the device comprising an internal housing portion that is removable and variably positionable on an internal surface of the flexible wall, the internal housing portion comprising a chemical detector sensor, which may be an optical chemical detector sensor. | 2013-08-01 |
20130196362 | DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE - Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples. | 2013-08-01 |
20130196363 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers. | 2013-08-01 |
20130196364 | RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING SYSTEM BASED ON BACTERIAL IMMOBILIZATION USING GELLING AGENT, ANTIBIOTIC DIFFUSION AND TRACKING OF SINGLE BACTERIAL CELLS - A testing method is disclosed. The testing method includes: providing a mixture solution of a gelling agent and a microbe to a gelling device; solidifying the mixture solution to form a solid thin film in which the microbe is immobilized; supplying a bioactive agent to the solid thin film and allowing the bioactive agent to diffuse into the solid thin film; and imaging the individual responses of the single microbial cells to the bioactive agent, and determining the minimum inhibitory concentration (MIC) of the bioactive agent based on the analysis of the images to obtain AST results. | 2013-08-01 |
20130196365 | ANTIBIOFILM NANOPOROUS NANOSTRUCTURES AND METHOD TO PRODUCE SAME - Durable nanoporous nanostructured materials that modify, eliminate and destroy biofilms that may develop due to the presence of bacteria, fungi and other microbes and method for making the same. Such nanoporous nanostructures may be deposited as coatings on a substrate and such coatings may include at least one nanopore and a plurality of nanoparticles which adhere to the substrate and/or other particles. The nanostructure can be produced using a single-sided electrode arrangement which is configured to produce an electrical arc or discharge at one end of an electrode and to emit the nanoparticles. The nanoparticles form a non-porous framework which delineates any nanopores and which can be deposited as one or more layers of nanothickness. Such nano structures may be resistant to removal from the substrate. Also described are testing methods and apparatus for the quick, accurate and simple evaluation of the efficacy of the antibiofilm properties of the nanoporous nano structure. | 2013-08-01 |
20130196366 | Method and Culture Medium for Enhanced Detection of Mycobacterium - The present invention relates to an improved culture medium and method for the enhanced growth and detection of | 2013-08-01 |
20130196367 | MODULATORS OF CANDIDA HYPHAL MORPHOGENESIS AND USES THEREOF - The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof. | 2013-08-01 |
20130196368 | Electrophysiological Recording System and Methods of Using Same - Electrophysiological recording systems for analysis of cultured cells include an recording device and a housing for supporting the electrophysiological recording device. The device has a porous membrane with top and bottom surfaces and a plurality of pores extending between the top and bottom surfaces. The porous membrane defines a first cell culture region disposed on the top surface and an opposed second cell culture region disposed on the bottom surface. The electrophysiological recording device has a plurality of electrodes positioned on the porous membrane in between a first insulation layer and a second insulation layer. The plurality of electrodes extend to the first cell culture region of the porous membrane. Recording ends of the electrodes measure electrical properties of cells cultured within the first and second cell culture regions, while the contact ends of the electrodes are positioned in electrical communication with data acquisition equipment. | 2013-08-01 |
20130196369 | Methods of Culturing Retinal Pigmented Epithelium Cells, Including Xeno-Free Production, RPE Enrichment, and Cryopreservation - The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided. | 2013-08-01 |
20130196370 | FIXATIVE AND STAINING SOLUTIONS - The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens. | 2013-08-01 |
20130196371 | TISSUE CASSETTE ASSEMBLY - A tissue cassette includes a body having a first floor and a first perimeter wall encircling and extending from the first floor so that the first floor and first perimeter wall at least partially bound a body cavity, the first floor having a plurality of spaced apart openings extending therethrough. A mold has a second floor and a second perimeter wall encircling and extending from the second floor so that the second floor and second perimeter wall at least partially bound a mold cavity, the second floor having at least one micropore extending therethrough, the at least one micropore having a maximum diameter less than 0.040 inches. A hinge couples the body to the mold so that the body and mold can move between a closed position wherein the first floor overlies the second floor so as to form a tissue compartment therebetween and an open position. | 2013-08-01 |
20130196372 | DEVICE AND METHOD FOR CELL FREE ANALYTICAL AND PREPARATIVE PROTEIN SYNTHESIS - A device is disclosed which contains one or more pores | 2013-08-01 |
20130196373 | MODIFIED DNA-BINDING PROTEINS AND USES THEREOF - Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences. | 2013-08-01 |
20130196374 | CIS-ACTING ELEMENT AND USE THEREOF - The expression level of a desired gene is significantly improved when a filamentous fungus or the like is used as a host cell. The cis-acting element according to the present invention has a region in which the XlnR/Ace2-binding sequence (ggctaa) and the Hap complex-binding sequence (ccaat) are arranged with a spacer sequence of 0 to 100 nucleotides between them. Also, a transformant having the cis-acting element according to the present invention is cultured in a xylan-containing medium, for example, so that the expression level of a desired gene can be significantly improved. | 2013-08-01 |
20130196375 | BIOPHARMACEUTICAL PROCESS APPARATUSES ASSEMBLED INTO A COLUMN - A bio factory apparatus capable of Up-Stream production of biologic material products or biologics products in a liquid volume and processing of biologic or biologic material products Down-Stream, comprising at least one first Up-Stream producing capsule and at least one second Down-Stream processing capsule, said capsules capable of being stacked in any order and any number within a column. | 2013-08-01 |
20130196376 | Method for the High Level Expression of Active Lymphotoxin-Beta Receptor Immunoglobulin Chimeric Proteins and Their Purification - Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification. | 2013-08-01 |
20130196377 | PROTEIN COMPLEX AND METHOD OF PREPARING SAME - A protein complex including at least two monoclonal antibodies is provided. By using the protein complex, a system for simultaneously targeting at least two antigens is effectively constructed. | 2013-08-01 |
20130196378 | HUMAN MONOCLONAL ANTIBODY - The present invention provides an anti-CD81 antibody usable as a pharmaceutical product for human. Specifically, the present invention provides an anti-human CD81 antibody capable of binding to a peptide region consisting of the amino acid sequence of the amino acid numbers 80 to 175 in the amino acid sequence shown in SEQ ID NO:22. | 2013-08-01 |
20130196379 | Antibodies - The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields. | 2013-08-01 |
20130196380 | IN VITRO PROCESS FOR THE PREPARATION OF ANTIBODIES OF THE IGG TYPE - An in vitro process for the preparation of antibodies of the IgG type, comprising the steps of: i. challenging dendritic cells obtained from a donor with an antigen against which the antibodies to be prepared are directed; ii. challenging CD4+ T cells obtained from the same donor with fragments of the antigen presented by the dendritic cells from step L, with the proviso that the dendritic cells are ones essentially not secreting interferon-γ (IFN-γ) and interleukin 12 (IL-12), to generate antigen-specific CD4+ Th2 cells; iii. challenging with the antigen a B cell population obtained from the same donor and including a sufficient proportion of naive B cells; and iv. contacting the antigen-specific CD4+ Th2 cells according to ii. with at least a fraction of the B cell population from iii. to form an antigen-specific plasma cell; v. immortalizing said antigen-specific plasma cell; and vi. isolating the IgG antibodies formed by said antigen-specific plasma cell. | 2013-08-01 |
20130196381 | CELL-BASED PRODUCTION OF NANULOSONATES - The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-α-D-glucopyranose. Methods for producing the sugars are also provided. | 2013-08-01 |
20130196382 | DNA POLYMERASES WITH IMPROVED ACTIVITY - Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases. | 2013-08-01 |
20130196383 | Method of Producing Dicer - The present disclosure provides a method for producing a Dicer polypeptide in a prokaryotic host cell. The present disclosure further provides a purified Dicer complex. The present disclosure further provides kits for producing a Dicer polypeptide in a prokaryotic host cell. | 2013-08-01 |
20130196384 | INCREASED POLY (ALPHA 1,3 GLUCAN) YIELD USING TETRABORATE - A process for production of poly (α 1,3 glucan) from a renewable feedstock, for applications in fibers, films, and pulps. The effect of addition of tetraborate in increasing the yield of the desired end products, poly (α 1,3 glucan) and fructose, and decreasing formation of the undesired by-product leucrose. | 2013-08-01 |
20130196385 | PmST2 ENZYME FOR CHEMOENZYMATIC SYNTHESIS OF ALPHA-2-3-SIALYLGLYCOLIPIDS - The present invention provides novel methods for preparing glycolipid products. Novel sialyltransferases are also disclosed. | 2013-08-01 |
20130196386 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2013-08-01 |
20130196387 | Polypeptides Having Endoglucanase Activity And Polynucleotides Encoding Same - The present invention provides isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cell comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2013-08-01 |
20130196388 | PROCESS FOR PRODUCING OPTICALLY ACTIVE SUCCINIMIDE DERIVATIVES - A process for efficiently producing optically active succinimide derivatives as key intermediates of (3R)-2′-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine}-1′,2,3′,5(2′H)-tetraone, which comprises the following reaction steps, and the step 2 is performed by using a non-animal-derived enzyme. | 2013-08-01 |
20130196389 | NOVEL TRANSAMINASE EXHIBITING HIGH ACTIVITY FOR GLUTAMIC ACID, GENE ENCODING SAME, AND METHOD FOR USING THEM - A method for inexpensively and efficiently producing an optically active amino compound useful as an intermediate for pharmaceutical preparations, agricultural chemicals, or the like, from a ketone compound is provided. Specifically, a polypeptide exhibiting higher activity for glutamic acid as an amino donor than that for L-alanine, and, having novel transaminase activity for generating (S)-1-benzyl-3-pyrrolidinone with high optical purity of 93% or more, a gene encoding the same, and a transformant expressing the gene at a high level are also provided herein. | 2013-08-01 |
20130196390 | METHOD OF PRODUCING BIOFUEL, BIODIESEL, AND OTHER VALUABLE CHEMICALS - a method for producing a hydrocarbon based product (e.g., biofuel or biodiesel), a microorganism (e.g., algae) that can be cultivated and harvested for producing a hydrocarbon based product, a method for producing a hydrocarbon based product from a by-product of biodiesel production, and a microorganism that can be cultivated from a by-product of biodiesel production and harvested for producing hydrocarbon based product. | 2013-08-01 |
20130196391 | PRODUCTION OF FATTY ACIDS BY HETEROLOGOUS EXPRESSION OF GENE CLUSTERS FROM MYXOBACTERIA - The invention relates to a process for producing one or more polyunsaturated fatty acids by means of heterologous gene expression comprising the steps of providing a production organism which comprises a heterologous gene cluster encoding a polyunsaturated fatty acid biosynthetic pathway encompassing a subsequence ER encoding an enoylreductase and a subsequence AT encoding an acyltransferase, growing the production organism in the presence of a fermentable carbon source whereby one or more polyunsaturated fatty acids are produced, and optionally recovering the one or more polyunsaturated fatty acids. | 2013-08-01 |
20130196392 | MICROALGAE BIOFUEL PRODUCTION SYSTEM - A system for processing oil from algae is disclosed. Specifically, the system involves the use of a consortium of algae strains as its input, wherein each algae strain has a unique characteristic for resisting/dominating a particular operational/environmental factor. Also, the system recycles byproducts of the process for use as nutrients during algae growth and oil production. The system includes a conduit for growing algae and an algae separator that removes the algae from the conduit. Also, the system includes a device for lysing the algae and an oil separator to remove the oil from the lysed matter. Further, the system includes a biofuel reactor that receives oil from the oil separator and synthesizes biofuel and glycerin. Moreover, the algae separator, oil separator and biofuel reactor all recycle byproducts back to the conduit to support further algae growth. | 2013-08-01 |
20130196393 | PROCESS FOR SEPARATING POLYUNSATURATED FATTY ACIDS FROM LONG CHAIN UNSATURATED OR LESS SATURATED FATTY ACIDS - A process for separating polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapen-taenoic acid (EPA) from less saturated long chain fatty acids (LCFAs) in a lipid composition, wherein said PUFAs and LCFAs are present as (i) triglycerides, or (ii) free fatty acids or monoalkyl esters, by exchange of at least a portion of LCFAs with short and/or medium chain fatty acids (MCFAs). The process can suitably be employed on marine derived oil, marine oil 2 derived oil products and other sources of PUFAs, including PUFA-rich singe cell oils (SCOs), and oils from genetically modified organisms with a modified lipid metabolism. The inventive process is based on novel use of lipases and distillation techniques, selectively chemically modifying species in the substrate material such that the desired species and chemically similar species become sufficiently dissimilar to be separable. Thus PUFA can be effectively enriched from material such as 30 herring oil with low PUFA content and high contant of equal length monounsaturated fatty acids such as 20:1 and 22:1 fatty acids. | 2013-08-01 |
20130196394 | COMPOSITIONS AND METHODS FOR BACTERIAL LYSIS AND NEUTRAL LIPID PRODUCTION - A cyanobactenum that produces neutral lipids or alkanes, such as FAME OR FAEE, which may be used for biofuel production. | 2013-08-01 |
20130196395 | ENZYME-CONTAINING MINI-EMULSIONS - The present invention relates to a mini-emulsion which comprises at least one hydrolase, where the continuous phase of the mini-emulsion contains at least one oxidant, while the dispersed phase comprises at least one C | 2013-08-01 |
20130196396 | EXTRACELLULAR ALDONOLACTONASE - The present disclosure relates to hydrolysis of hexose-δ-lactones by use of an | 2013-08-01 |
20130196397 | COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS - The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided are methods for the production of 4-HB and BDO. | 2013-08-01 |
20130196398 | METHODS OF HYDROLYZING PRETREATED DENSIFIED BIOMASS PARTICULATES AND SYSTEMS RELATED THERETO - A method is provided in which pretreated and densified cellulosic biomass particulates can hydrolyzed at a high solids loading rate as compared with the solids loading rate of loose hydrolysable cellulosic biomass fibers. The resulting high concentration sugar-containing stream can be easily converted to biofuels or an entire suite of other useful bioproducts. | 2013-08-01 |
20130196399 | SACCHAROMYCES STRAIN WITH ABILITY TO GROW ON PENTOSE SUGARS UNDER ANAEROBIC CULTIVATION CONDITIONS - The invention relates to an improved | 2013-08-01 |
20130196400 | TREATING BIOMASS TO PRODUCE MATERIALS USEFUL FOR BIOFUELS - Fermentable sugar useful for the production of biofuels can be produced from biomass by contacting the biomass with a solution containing at least one α-hydroxysulfonic acid. The α-hydroxysulfonic acid can be easily removed from the product and recycled. | 2013-08-01 |
20130196401 | HYDROLYTIC ENZYME MIXTURES FOR SACCHARIFICATION OF LIGNOCELLULOSIC POLYSACCHARIDES - The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications. Some embodiments relate to a method of producing ethanol using the cell wall degradative systems of the present invention. | 2013-08-01 |
20130196402 | COMPOSITIONS AND METHODS FOR PRODUCING ISOPRENE FREE OF C5 HYDROCARBONS UNDER DECOUPLING CONDITIONS AND/OR SAFE OPERATING RANGES - The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity. | 2013-08-01 |
20130196403 | PROCESS AND SYSTEM FOR RECOVERING PHOSPHORUS FROM WASTEWATER - Methods and systems for recovery of phosphorus from wastewater and producing inorganic phosphorus complexes. | 2013-08-01 |
20130196404 | METHOD FOR DETACHMENT AND PREPARATION OF LIVING MICROORGANISMS - A method for immobilizing living microorganisms includes a step (1) of disposing a solution containing microorganisms as an electrolyte on the surface of a substrate at least one portion of which is an electrode, and applying a constant potential to the electrode to cause at least a portion of the microorganisms to attach to the surface of the substrate. The constant potential in step (1) is greater than −0.5 V but not greater than −0.2 V (vs Ag/AgCl) or greater than +0.2 V but not greater than +0.4 V (vs Ag/AgCl). The electrolyte in step (1) does not contain a source of nutrition for the microorganisms. | 2013-08-01 |
20130196405 | POROUS FIBER, METHODS OF MAKING THE SAME AND USES THEREOF - There is provided a porous fiber having a core-shell configuration, wherein the pores on the fiber are configured to encapsulate and thereby retain a biological material therein. | 2013-08-01 |
20130196406 | NOVEL PROTEIN-POLYMER NANOCAPSULES - Disclosed are protein nanocapsules, and in particular, nanocapsules that have high thermal stability and very high resistance to thermal inactivation when subjected to steam sterilization. | 2013-08-01 |
20130196407 | Non-Leachable Magnetic Cross-Linked Enzyme Aggregate - A non-leachable, crosslinked, on a nanometer scale formed magnetic enzyme aggregate, consisting of a non-layered, hybrid nano-composite of functionalised magnetic nanoparticles and aggregated enzyme particles, is described. The magnetic enzyme aggregate can have a high enzyme content, of up to 99%. The high enzyme content allows the use on a small scale, such as for example in a fluidised bed, of the magnetic enzyme aggregate. Also, a process for the preparation of the present magnetic enzyme aggregate is described. | 2013-08-01 |
20130196408 | KETOREDUCTASES AND USES THEREOF - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. | 2013-08-01 |
20130196409 | Targeted 2'-O-Methylation of Telomerase Non-Coding RNA - Processes and C/D box small nucleolar RNAs (snoRNAs) for altering telomerase activity and altering telomerase length are described. The processes of the invention involve the use of C/D box snoRNAs for targeted 2′-O-methylation modification of nucleotides in a pseudoknot region of the telomerase RNA. Depending on their position, the 2′-O-methylation modifications can cause an increase in telomerase activity and subsequent telomere lengthening or a decrease in telomerase activity and subsequent telomere shortening. | 2013-08-01 |
20130196410 | COMPOSITIONS AND METHODS FOR MODIFYING THE GLYCOSYLATION PATTERN OF A POLYPEPTIDE - Provided herein are methods and compositions for expressing a modified polypeptide in a host cell, wherein the modified polypeptide comprises a terminal mannose at an N-linked glycosylation site of the polypeptide. The methods and compositions used herein involve the use of RNA effector molecules (e.g., siRNA, dsRNA etc) administered to a host cell to modify the expression of target genes involved in protein glycosylation (e.g., Mgat1, Mgat4, SLC35A1, SLC35A2 or GNE). | 2013-08-01 |
20130196411 | POLYNUCLEOTIDES, VECTORS, AND HOST CELLS EXPRESSING IMPROVED LIPASE VARIANTS - The present invention relates to a newly identified lipase belonging to the Ustilaginaceae family of Basidomycetes and variants thereof. The invention also relates to polynucleotides encoding the lipase and the variants thereof. The invention further relates to procedures for producing the lipase, and variants thereof, polypeptides and polynucleotides. The invention further relates to lipase variants with an increased trans-selectivity. The invention further relates to lipase variants with a preference for long chain fatty acid esters or carboxylic acid moieties with a chain length greater than C | 2013-08-01 |
20130196412 | MAGI POLYNUCLEOTIDES, POLYPETIDES, AND ANTIBODIES - MAGI polypeptides, polynucleotides, antibodies, and methods for producing the same by recombinant techniques are disclosed. Also disclosed are methods for utilizing MAGI polypeptides and polynucleotides in diagnostic assays. | 2013-08-01 |
20130196413 | Engineered plant cysteine proteases and their uses - The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing. | 2013-08-01 |
20130196414 | DEGRADABLE CLOSTRIDIAL TOXINS - The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras. | 2013-08-01 |
20130196415 | MICROORGANISM BELONGING TO GENUS BACILLUS, THROMBOLYTIC ENZYME, AND METHOD FOR TREATING WASTE - A microorganism belonging to the genus | 2013-08-01 |
20130196416 | PROTEIN AND NUCLEIC ACID DELIVERY VEHICLES, COMPONENTS AND MECHANISMS THEREOF - Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles. | 2013-08-01 |
20130196417 | METHOD FOR PRODUCING SCYLLO-INOSITOL - It is intended to provide a novel NAD | 2013-08-01 |
20130196418 | ECOSYSTEM RECOVERY FROM IONIZING RADIATION - A method for aiding an ecosystem in recovering from the effects of exposure to radiation, comprising introducing microorganisms into the ecosystem, the microorganisms preferably replacing native microorganisms destroyed, killed, or reduced in number by the exposure to radiation. A method for aiding an ecosystem in recovering from the effects of exposure to radiation by, prior to the ecosystem being exposed to radiation, cataloging the microorganisms in the soil of the ecosystem; after the ecosystem being exposed to radiation, cataloging the microorganisms in the soil of the ecosystem; and introducing into the ecosystem microorganisms before and/or after the ecosystem has been exposed to radiation. The microorganisms introduced into the ecosystem are microorganisms present in the ecosystem prior to exposure to radiation or microorganisms equivalent to the microorganisms present in the ecosystem prior to exposure to radiation. | 2013-08-01 |
20130196419 | BIOCEMENTATION OF PARTICULATE MATERIAL IN SUSPENSION - The present invention is directed to a composition and method to decrease the amount of particulate material in suspension, both in a liquid or in air, especially in industrial processes that generate suspended particulate material. In particular, the invention is directed to a composition and method to decrease the amount of particulate material in suspension in air or a liquid through agglomeration and subsequent biocementation, by application of an exopolysaccharide (EPS) source that can be direct or through inoculation with microorganisms that produce said EPS. This allows in a first step to settle the particulate material and subsequently the cementation of the material when there are calcium containing compounds in the particulate material that has been settled in the first step, by means of the inoculation of a second class of microorganisms that have ureolytic activity. | 2013-08-01 |
20130196420 | COMPOSITIONS AND METHODS FOR WASTE REMEDIATION - The present invention relates to compositions and methods for the bioremediation of hydrocarbon-containing waste, such as drill mud and drill cuttings from oil and gas wellbores, drill waste deposit sites, oil spills, oil and gas production waste, and contaminated surfaces, using wood chips comprising microorganisms of mountain pine beetle. | 2013-08-01 |
20130196421 | MARKER FOR READINGS TAKEN FROM ALTERNATIVE SITE TESTS - A meter for determining the concentration of an analyte in a fluid sample comprises a memory device, electrical circuitry and a detection device for distinguishing between an alternative site test and a standard site test. The memory device is adapted to store information. The electrical circuitry is adapted to determine the analyte concentration of the fluid sample located on a test sensor. The electrical circuitry is in electronic communication with the memory device. The electrical circuitry communicates the determined analyte concentration to the memory device for storage. | 2013-08-01 |
20130196422 | SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS - Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples. | 2013-08-01 |
20130196423 | METHOD AND SYSTEM FOR PROCESSING ORGANIC WASTE - The current application is directed to systems and methods for processing organic waste using aerobic bacterial digestion of organic waste. In one implementation, the system includes a covered enclosure with a non-porous floor and sidewalls within which a floor-scraping, helical auger with serrated or toothed edges is mechanically powered and translated in two dimensions in order to chop, mix, lift, and move composting organic waste towards a discharge end of the enclosure. The vessel additionally includes a rotatably mounted screen, in one implementation, for screening the composted organic waste as it is discharged. The vessel additionally includes, in one implementation, perforated, pressurized tubes for introducing pressurized air into the organic waste as it is processed as well as a flexible water hose for introducing moisture into the organic waste as it is being processed. Various sensors are employed to monitor and control the moisture, temperature, and other physical parameters of the organic waste by controlling rotation and translation of the helical, floor-scraping auger and, in certain implementations, controlling the pressure of pressurized air input into the perforated, pressurized tubes and the rate of water flow to the flexible water hose. | 2013-08-01 |
20130196424 | SACCHARIDE-SOLUTION PRODUCING APPARATUS, FERMENTATION SYSTEM, SACCHARIDE-SOLUTION PRODUCING METHOD, AND FERMENTATION METHOD - A saccharide-solution producing apparatus | 2013-08-01 |
20130196425 | System and Process for Separating a Material - Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations. | 2013-08-01 |
20130196426 | BASE BODY AND METHOD OF MANUFACTURING BASE BODY - Disclosed is a substrate ( | 2013-08-01 |
20130196427 | CANCER ANTIGEN PEPTIDES DERIVED FROM WT1 - The present invention relates to HLA-A26-binding cancer antigen peptides derived from WT1, polynucleotides encoding said peptide, CTL-inducers, and cancer vaccine comprising said peptide or polynucleotide. | 2013-08-01 |
20130196428 | Cells expressing Th1 characteristics and cytolytic properties - A novel cell type has been generated that has both Th1 characteristics and cytolytic activity. These Th1/killer cells are CD4+ cells purified from peripheral blood and manipulated to have Th1 characteristics such as production of IFN-gamma combined with cytolytic activity similar to cytotoxic T-cells (CTL). The CTL activity is targeted toward diseased cells, not normal cells. The cytolytic activity of the Th1/killer cells is mediated by Granzyme B-Perforin mechanism and results in apoptotic death of diseased cells. Methods of producing and using these Th1/killer cells include isolating CD4+ cells from peripheral blood, activating the CD4+ T-cells to form Th1/killer cells and administering these Th1/killer cells with the cytolytic activity to a patient wherein the Th1/killer cells are allogeneic to the patient. | 2013-08-01 |
20130196429 | Protein-Free Gamete and Embryo Handling and culture Media Products - This invention discloses a substantially protein-free cell culture solution for assisted reproductive technologies and methods of use thereof. | 2013-08-01 |
20130196430 | PROTEIN PRODUCTION - The invention concerns the field of protein production and cell culture technology. CERT is identified as a novel in vivo PKD substrate. Phosphorylation on serine 132 by PKD decreases the affinity of CERT towards its lipid target phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity, identifying PKD as a regulator of lipid homeostasis. The present invention shows that CERT in turn is critical for PKD activation and PKD dependent protein cargo transport to the plasma membrane. The interdependence of PKD and CERT is thus a key to the maintenance of Golgi membrane integrity and secretory transport. | 2013-08-01 |
20130196431 | TISSUE ENGINEERED BLOOD VESSEL - Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed. | 2013-08-01 |
20130196432 | BIOLOGICALLY ACTIVE MOLECULES FOR INFLUENCING VIRUS-, BACTERIA-, PARASITE-INFECTED CELLS AND/OR TUMOR CELLS AND METHOD FOR THE USE THEREOF - The aim of the invention is to effectively inhibit virus-, bacteria-, or parasite-infected cells and tumor cells in a targeted manner, even in the case of mutations. According to the invention, biologically active molecules are administered, said biologically active molecules including at least one protease inhibitor for at least one specific target protease of the virus-, bacteria-, or parasite-infected cells and/or tumor cells and at least one peptide-inhibited siRNA, PNA or RNA, the peptide bond of which is broken by the at least one target protease for the purpose of activating the peptide-inhibited siRNA, PNA or RNA. The molecules are used, for example, to influence the gene expression of diseased and infected organs or cells. | 2013-08-01 |
20130196433 | Boronate-Mediated Delivery of Molecules into Cells - Methods for enhancing cellular uptake of cargo molecules by boronating the cargo molecule, particularly with one or more phenylboronic acid groups. Cellular uptake includes at least partial uptake into the cytosol. Boronation includes ligating, crosslinking or otherwise bonding one or more phenylboronic acids substituted to contain a reactive group to a cargo molecule. Boronation also includes ligating, crosslinking or otherwise bonding a phenylboronated oligopeptide to a cargo molecule. The phenylboronate groups are optionally conjugated to the cargo molecule via linking moieties that can be selectively cleaved, such cleavable linkers can allow the phenylboronate groups to be removed from the cargo molecule after the boronated cargo molecule is introduced into the cell. The invention includes certain phenylboronates which are boronation reagents, certain boronated oligopeptides and certain boronated peptides and proteins. The invention also includes kits for enhancing cellular uptake of cargo molecules by boronation with one or more phenylboronates or boronated oligopeptides. | 2013-08-01 |
20130196434 | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND - One aspect of the present invention relates to a double stranded nucleic acid useful as an siRNA, that has a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one nucleoside comprising a non-natural nucleobase. Another aspect of the invention relates to a method of gene silencing, comprising administering to a mammal in need thereof a therapeutically effective amount of a double-stranded oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. | 2013-08-01 |
20130196435 | STENCIL PATTERNING METHODS AND APPARATUS FOR GENERATING HIGHLY UNIFORM STEM CELL COLONIES - A method for producing highly uniform cell colonies in a cell culture dish with the use of stencils made from an elastomeric sheet sized to fit within the cell culture dish, having a singular opening or a plurality of openings of a number, pitch and diameter configured to optimally control the geometric growth parameters of a cell colony. The uniform cell colonies are produced by placing the stencil in a cell culture dish and hydropilizing the stencil. The stencil is overlayed with cell culture media and seeded with seed cells that are preferably grown for at least a day before the stencil is removed to produce a pattern of seeded cells with controlled pitch, colony diameter and density within the culture dish that grow to become highly uniform cell colonies. A kit with culture dish, stencil, culture media and growth media is also provided. | 2013-08-01 |
20130196436 | CARDIOMYOCYTE PRODUCTION - Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided. | 2013-08-01 |
20130196437 | CARDIOMYOCYTE PRODUCTION - Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided. | 2013-08-01 |
20130196438 | TISSUE ENGINEERED BLOOD VESSELS - Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed. | 2013-08-01 |
20130196439 | TISSUE ENGINEERED BLOOD VESSEL - Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed. | 2013-08-01 |
20130196440 | TISSUE ENGINEERED BLOOD VESSEL - Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed. | 2013-08-01 |
20130196441 | ELECTROPORATION ELECTRODE CONFIGURATION AND METHODS - Provided herein are the concept that “singularity-based configuration” electrodes design and method can produce in an ionic substance local high electric fields with low potential differences between electrodes. The singularity-based configuration described here includes: an anode electrode; a cathode electrode; and an insulator disposed between the anode electrode and the cathode electrode. The singularity-based electrode design concept refers to electrodes in which the anode and cathode are adjacent to each other, placed essentially co-planar and are separated by an insulator. The essentially co-planar anode/insulator/cathode configuration bound one surface of the volume of interest and produce desired electric fields locally, i.e., in the vicinity of the interface between the anode and cathode. In an ideal configuration, the interface dimension between the anode and the cathode tends to zero and becomes a point of singularity. | 2013-08-01 |
20130196442 | Liquid Reagent Containing Microchip and Method of Using the Same, and Packaged Liquid Reagent Containing Microchip - Provided is a liquid reagent containing microchip having a fluid circuit formed of a space inside thereof. Liquid present in the fluid circuit is transferred to a desired position in the fluid circuit by applying centrifugal force. The fluid circuit includes a reagent retaining portion for accommodating a liquid reagent. The microchip includes an air introduction path formed of a groove provided on an outer surface of the microchip and coupled to the reagent retaining portion for introducing air into the reagent retaining portion, and a sealing portion provided so as to be detachable from the microchip for sealing the air introduction path. A method of using the microchip and a packaged liquid reagent containing microchip using the microchip are also provided. | 2013-08-01 |
20130196443 | APPARATUS AND METHOD FOR DATING A BODY OR BODY SAMPLE - A method and apparatus for dating a dating a body sample, such as blood, includes taking at least one spectroscopic measurement ( | 2013-08-01 |
20130196444 | Method and Device for Detection of an Analyte - The present invention relates to a method, device, and kit for analyzing a sample for determining the presence or amount of an analyte, particularly carbohydrate, more particularly sugar, in the sample using a fabric. | 2013-08-01 |
20130196445 | METHOD AND DEVICE FOR ANALYZING SULFUR IN METAL SAMPLE - An analyzing method which enables highly precise and rapid quantitative analysis of sulfur contained in a metal sample, includes: combusting a metal sample containing a sulfur component under pure oxygen gas atmosphere to oxidize the sulfur component into sulfur dioxide; and quantitatively analyzing sulfur in the metal sample through analysis, according to a UV fluorescence method, of a sulfur dioxide containing gas containing the sulfur dioxide generated by combustion of the metal sample. | 2013-08-01 |
20130196446 | SYSTEM AND METHOD FOR CODING INFORMATION ON A BIOSENSOR TEST STRIP - The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted. | 2013-08-01 |
20130196447 | MICROFLUIDIC ELEMENT FOR THOROUGHLY MIXING A LIQUID WITH A REAGENT - A microfluidic element for thoroughly mixing a liquid with a reagent used for the analysis of the liquid for an analyte contained therein and a method thereof are disclosed. The microfluidic element has a substrate and a channel structure. The channel structure includes an elongate mixing channel and an output channel. The mixing channel has an inlet opening and an outlet opening, and is implemented to mix the reagent contained therein with the liquid flowing through the inlet opening into the mixing channel. The outlet opening of the mixing channel is in fluid communication to the output channel. The outlet opening is positioned closer to the middle of the length of the mixing channel than the inlet opening. | 2013-08-01 |
20130196448 | SURFACE PLASMON RESONANCE SENSOR - An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen. | 2013-08-01 |
20130196449 | ELECTRICALLY DRIVEN DEVICES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY - An electrically driven device for surface enhanced Raman spectroscopy includes a substrate, a Raman signal-amplifying structure positioned on the substrate, and an analyte receptor attached to a structure chosen from i) the Raman signal-amplifying structure, or ii) the substrate near the Raman signal-amplifying structure, or iii) combinations of i and ii. The analyte receptor has a selective binding affinity for an analyte. Conductive elements are positioned relative to one another and to the analyte receptor such that the conductive elements together produce an electric field in the vicinity of the analyte receptor when a voltage bias is applied between the conductive elements. | 2013-08-01 |
20130196450 | METHOD FOR COATING NANOPARTICLES - The invention relates to methods for coating nanoparticles with a limited amount of a binding partner and nanoparticles obtainable by the methods disclosed. In particular, the invention is of interest, when coating with only a limited amount of protein is desirable. | 2013-08-01 |
20130196451 | MANUFACTURING METHOD OF MAGNETIC TUNNELING JUNCTION DEVICE - A method of manufacturing a magnetic tunneling junction device, includes: forming a magnetic pinned layer over a substrate; forming an insulating film over the magnetic pinned layer; forming a recess in the insulating film, the recess reaching a bottom of the insulating film; forming a tunneling insulating film over a bottom and side walls of the recess and over the insulating film; forming a magnetic free layer over the tunneling insulating film; forming an upper electrode conductive film on the magnetic free layer; and oxidizing a portion of the magnetic free layer along the side walls of the recess. | 2013-08-01 |
20130196452 | WIRE BONDING METHOD IN CIRCUIT DEVICE - A wire bonding method in a circuit device mounted on a lead frame, the wire bonding method including: counting a stop time if an operation of a capillary stops; removing a contaminated free air ball (FAB) formed on an end of the capillary if the stop time exceeds a reference time; forming a new FAB; and restarting a wire bonding process. | 2013-08-01 |
20130196453 | PRESUMABLY DEFECTIVE PORTION DECISION APPARATUS, PRESUMABLY DEFECTIVE PORTION DECISION METHOD, FABRICATION METHOD FOR SEMICONDUCTOR DEVICE AND PROGRAM - Disclosed herein is a presumably defective portion decision apparatus, including: an arithmetic operation section configured to divide a level difference included in level difference data which indicate a level difference distribution on the surface of a semiconductor device into two or more unit level differences in the depthwise direction of the level difference and determine, for each of the unit level differences obtained by the division, a relationship between the height of a contour line at a level difference position of an upper face and an area of an opening surrounded by the contour line to decide presence or absence of a presumably defective portion. | 2013-08-01 |
20130196454 | VAPOR DEPOSITION METHOD, VAPOR DEPOSITION DEVICE AND ORGANIC EL DISPLAY DEVICE - A coating film ( | 2013-08-01 |
20130196455 | TWO-BEAM LASER ANNEALING WITH IMPROVED TEMPERATURE PERFORMANCE - Systems and methods are disclosed for performing laser annealing in a manner that reduces or minimizes wafer surface temperature variations during the laser annealing process. The systems and methods include annealing the wafer surface with first and second laser beams that represent preheat and anneal laser beams having respective first and second intensities. The preheat laser beam brings the wafer surface temperate close to the annealing temperature and the anneal laser beam brings the wafer surface temperature up to the annealing temperature. The anneal laser beam can have a different wavelength, or the same wavelength but different orientation relative to the wafer surface. Reflectivity maps of the wafer surface at the preheat and anneal wavelengths are measured and used to select first and second intensities that ensure good anneal temperature uniformity as a function of wafer position. | 2013-08-01 |
20130196456 | Method for Stressing a Thin Pattern and Transistor Fabrication Method Incorporating Said Method - A method for stressing a pattern having a pattern surface, in a layer of semiconductive material that can be silicon on the surface of a stack of layers generated on the surface of a substrate, said stack comprising at least one stress layer of alloy Si | 2013-08-01 |
20130196457 | METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE - In some aspects of the invention, a circuit pattern of a front surface structure is formed in a front surface of a semiconductor wafer and an alignment mark is formed on the front surface of a semiconductor wafer. A transparent supporting substrate is attached to the front surface of the semiconductor wafer by a transparent adhesive. Then, a resist is applied onto a rear surface of the semiconductor wafer. Then, the semiconductor wafer is mounted on a stage of an exposure apparatus, with the supporting substrate down. Then, the alignment mark formed on the front surface of the semiconductor wafer is recognized by a camera, and the positions of the semiconductor wafer and a photomask are aligned with each other. Then, the resist is patterned. Then, a circuit pattern is formed in the rear surface of the semiconductor wafer. | 2013-08-01 |
20130196458 | METHOD OF TESTING THROUGH SILICON VIAS (TSVS) OF THREE DIMENSIONAL INTEGRATED CIRCUIT (3DIC) - In a method of testing a plurality of through silicon vias (TSVs) chained together by interconnect on a substrate, a test signal is applied to a first test pad among a plurality of test pads, and a return signal is measured at a second test pad among the plurality of test pads. At least one test pad of the plurality of test pads is grounded to the substrate. The remaining test pads of the plurality of test pads are either connected to the plurality of chained TSVs or are grounded. | 2013-08-01 |
20130196459 | HYBRID OPTOELECTRONIC DEVICE - A hybrid optoelectronic device having Group III-V and Si composition on a low-cost substrate is disclosed. A photonic integrated circuit implemented by the hybrid optoelectronic device is much inexpensive and superior to those implemented by the conventional Group III-V optoelectronic device. In the hybrid optoelectronic device, a physical vapor deposition method is used to form a RMG structure with a smooth surface, and further produce a RE structure on the RMG structure. It relates a monolithic process. The wavelength and the material which attract interest can be adjusted. Thereby, the optoelectronic device can be manufactured with large yield and productivity. High optical coupling efficiency that can be offered comes from the Group III-V active device to the Si passive device (optical access). This would be beneficial to the application to the photonic integrated circuit and suitable for future development of high-performance electronic and optoelectronic devices. | 2013-08-01 |