30th week of 2012 patent applcation highlights part 49 |
Patent application number | Title | Published |
20120190793 | METHOD FOR THE PRODUCTION OF SCAFFOLDS FOR TISSUE ENGINEERING, COMPRISING THE USEOF AN ANCHORING UNIT, AND SCAFFOLD PRODUCED THEREWITH - The present invention relates to a method for the production of scaffold materials and/or scaffolds for tissue and/or organ engineering, said method comprising the addition of at least one anchoring unit for a labelling agent, to at least one scaffold material and/or to at least one scaffold. | 2012-07-26 |
20120190794 | RELEASE AGENT, RELEASE MATERIAL, AND ADHESIVE TAPE - The present invention provides a release agent containing at least a nonreactive polyolefin, an aromatic isocyanate having 3 or more isocyanate groups in one molecule and a polyolefin polyol, wherein the content of the nonreactive polyolefin is not less than 80 wt %, and not less than 90 wt % of the nonreactive polyolefin has tensile elasticity at 23° C. of not more than 10 MPa and tensile fracture stress at 23° C. of not more than 8 MPa. | 2012-07-26 |
20120190795 | CATALYST FOR LIVING RADICAL POLYMERIZATION AND POLYMERIZATION METHOD - Provided is a low-cost, highly active, environmentally friendly living radical polymerization catalyst which does not require a radical initiator. An organic compound having an oxidation-reduction capability is used as a catalyst. Even if a radical initiator is not used, a monomer can be subjected to a radical polymerization to obtain a polymer having narrow molecular weight distribution. The cost of the living radical polymerization can be remarkably reduced. It is made possible to prevent adverse effects of using a radical initiator. The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages of the catalyst such as low toxicity of the catalyst, low amount of the catalyst necessary, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor (which do not require a post-treatment for a molded article), etc. | 2012-07-26 |
20120190796 | FLUORINATED ELASTIC COPOLYMER AND PROCESS FOR ITS PRODUCTION, AND CROSSLINKED RUBBER ARTICLE - To provide a fluorinated elastic copolymer excellent in crosslinkability irrespective of the molecular weight and a process for its production, as well as a crosslinked rubber article. | 2012-07-26 |
20120190797 | POLYMER COMPOSITIONS OF IMPROVED SCRATCH RESISTANCE, IMPROVED MECHANICAL STABILITY AND IMPROVED HAZE - The present invention provides a composition comprising (i) a polymer, (ii) an organic compound A carrying at least two amide functionalities, and (iii) 12 to 1'000 parts per million (ppm) of a compound B selected from the group consisting of an organic compound C carrying at least two amide functionalities, sugar alcohol acetals and derivatives thereof, metal salts of organic acids and precursor-systems thereof, metal salts of organic phosphoric acids and precursor-systems thereof and metal salts of polyols and precursor-systems thereof, and mixtures thereof, based on the weight of the polymer, as well as shaped articles obtainable from this composition. | 2012-07-26 |
20120190798 | CURABLE FLUOROELASTOMER COMPOSITIONS - Disclosed herein is a curable composition comprising a curable fluoroelastomer, a curative and an acid acceptor selected from the group consisting of a hydrous bismuth oxide nitrate compound and bismuth oxide. Cured articles made therefrom are resistant to volume swell in acids, coolant and in biofuel. | 2012-07-26 |
20120190799 | Polyamide Curative Composition - The present invention relates to a polyamide curative composition comprising a reaction product (P) of (1) at least three compounds of formula H | 2012-07-26 |
20120190800 | FUNCTIONALIZED POLYETHYLENE TEREPHTHALATE POLYMERS, FUNCTIONALIZED DERIVATIVE POLYMERS OF POLYETHYLENE TEREPHTHALATE, METHODS OF MAKING AND USING SAME - The presently disclosed and claimed inventive concept(s) relates generally to the functionalized polyethylene terephthalate polymers and functionalized derivatives of PET. More particularly, but not to be construed as limiting, the presently disclosed and claimed inventive concept(s) relate to lower molecular weight functionalized digested PET materials from digesting recycled and methods of making and using same. | 2012-07-26 |
20120190801 | Liquid Crystal Alignment Agent, Liquid Crystal Alignment Film Manufactured Using the Same, and Liquid Crystal Display Device Including the Liquid Crystal Alignment Film - A liquid crystal alignment agent is provided that includes a polymer including polyamic acid including a repeating unit represented by the following Chemical Formula 1, polyimide including a repeating unit represented by the following Chemical Formula 2, or a combination thereof. | 2012-07-26 |
20120190802 | POLYIMIDE POLYMER FROM NON-STOICHIOMETRIC COMPONENTS - A process for adjusting polyimide polymer properties includes combining monomers in a reaction mass to form a polyimide precursor. A property modifying moiety which is covalently bonded to an amine is then added to the reaction mass, and the reaction between the amine bonded to the property modifying moiety and the polyimide precursor is arrested before equilibrium. The polyimide precursor is imidized to form a polyimide polymer prior to equilibrium. The property modifying moiety can be evenly dispersed in the resulting polyimide polymer | 2012-07-26 |
20120190803 | HALF-METALLOCENE COMPOUNDS AND CATALYST COMPOSITIONS - The present invention provides polymerization catalyst compositions employing half-metallocene compounds with a heteroatom-containing ligand bound to the transition metal. Methods for making these hybrid metallocene compounds and for using such compounds in catalyst compositions for the polymerization of olefins also are provided. | 2012-07-26 |
20120190804 | DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS - This invention relates to catalyst compositions, methods, and polymers encompassing at least one first Group 4 metallocene compound comprising bridging η | 2012-07-26 |
20120190805 | SOLID CATALYST COMPONENT FOR POLYMERIZATION AND COPOLYMERIZATION OF ETHYLENE AND PROCESS FOR OBTAINING THE SAME - Disclosed is a process for obtaining a solid catalyst component for ethylene polymerization and copolymerization, wherein a carrier of particulate silica (65 to 85% by weight) is impregnated with a catalytically active portion (15 to 35% by weight) including titanium, magnesium, chlorine, alkoxy groups and at least one organometallic compound of the groups 1, 2, 12 or 13 of the periodic table. Further, the invention refers to the solid catalyst component thus obtained and to a process for ethylene polymerization and copolymerization wherein is used said catalyst. The catalyst obtained is suitable for the production of ethylene homo- and copolymers as narrow molecular weight distribution high density polyethylene (NMWHDPE) and linear low density polyethylene (LLDPE) with controlled morphology and improved structure. | 2012-07-26 |
20120190806 | Phosphine Borane Compounds Comprising Imidazol Groups And Method For Producing Phosphine Borane Compounds Comprising Imidazol Groups - The present invention relates to imidazolo-containing phosphinoborane compounds, to optically active ligands prepared using them, to transition metal complexes which comprise such ligands, and to catalysts which comprise such transition metal complexes. The present invention further relates to the particular processes for preparing the phosphinoborane compounds, the optically active ligands, the transition metal complexes and the catalysts, and to the use of the catalysts for organic transformation reactions. The present invention further relates to a process for preparing optically active ligands comprising imidazolo-containing phosphorus compounds using imidazolo-containing phosphinoborane compounds. | 2012-07-26 |
20120190807 | AQUEOUS EMULSION POLYMERIZATION PROCESS FOR PRODUCING FLUOROPOLYMERS - A method of making a fluoropolymer in the presence of a fluorinated surfactant. | 2012-07-26 |
20120190808 | POLYARYLACETYLENES CONTAINING SILOXANE, SILANE, AND CARBORANE MOIETIES - Disclosed herein are the compounds shown below. Each R is an organic group, Cb is a carborane group, and —C | 2012-07-26 |
20120190809 | FLUORINATED COMPOUND AND FLUORINATED POLYMER - To provide a fluorinated compound having an R | 2012-07-26 |
20120190810 | COPOLYMERS, POLYMERIC PARTICLES COMPRISING SAID COPOLYMERS AND COPOLYMERIC BINDERS FOR RADIATION-SENSITIVE COATING COMPOSITIONS FOR NEGATIVE-WORKING RADIATION-SENSITIVE LITHOGRAPHIC PRINTING PLATES - There is provided a copolymer and polymeric particle comprising the copolymer, a method of producing a polymeric particle, a copolymeric binder, a method of producing a copolymeric binder, a near infrared radiation-sensitive coating composition, a negative working lithographic offset printing plate, a method of producing a negative working lithographic offset printing plate and methods of imaging the plate and printing with the imaged plate. | 2012-07-26 |
20120190811 | PROCESS FOR THE PREPARATION OF AN ALLYL ALKYL ETHER BY CATALYTIC ALLYLATION - The invention provides a process for the preparation of an allyl alkyl ether comprising the allylation of an aliphatic hydroxyl containing compound with an allyl source in the presence of a catalyst, wherein the catalyst is a transition metal complex with a phosphine ligand, wherein the allylation is carried out in the presence of an acid in an amount of at least 0.1 mol % calculated on the aliphatic hydroxyl containing compound. This invention further provides a process for the preparation of epoxy resins wherein as intermediate use is made of the allyl alkyl ethers prepared by the process of the invention. | 2012-07-26 |
20120190812 | PLANT-BASED POLYCARBONATE RESIN AND PRODUCTION METHOD THEREOF - Provided is an environmentally friendly novel plant-based polycarbonate resin. Specifically, disclosed are: a plant-based polycarbonate resin which is a polymer derived from a plant-based material having a plurality of hydroxyl groups, in which molecules of the plant-based material are linked to each other through carbonate groups to form the polymer; and a production method of the polycarbonate resin. | 2012-07-26 |
20120190813 | LIQUID-CRYSTAL POLYMER AND MOLDED ARTICLES - To provide an easily-manufactured liquid-crystalline polymer having high thermal conductivity, as well as a molded article that is formed of the liquid crystalline polymer and has a property of being highly mechanical. A liquid-crystalline polymer is used that is formed by polymerizing monomers having an asymmetrical molecular structure, in which the enthalpy of fusion ΔH measured by way of DSC (Differential Scanning calorimetry) is greater than or equal to 2.5 J/g (joules per gram) and less than or equal to 10 J/g, and the inherent viscosity (I.V.) is greater than or equal to 5 dl/g and less than or equal to 7 dl/g. It is preferable for the monomer having asymmetrical molecular structure to be at least one selected from a group consisting of 4-hydroxybenzoic acid (HBA), 6-hydroxy-2-naphthoic acid (HNA), N-acetyl-p-aminophenol (APAP), and 4-hydroxy-4′-biphenylcarboxylic acid (HBCA). | 2012-07-26 |
20120190814 | Thiol Protecting Group - The present invention relates to the use of a compound comprising a moiety of formula (I) as a reagent for protecting a thiol group in a thiol compound | 2012-07-26 |
20120190815 | AZACYCLOHEXAPEPTIDE OR ITS PHARMACEUTICAL ACCEPTABLE SALT, PREPARING METHOD AND USE THEREOF - The present invention disclosed a novel azacyclohexapeptide or pharmaceutically acceptable salts, preparation methods and uses thereof. The structure of the azacyclohexapeptide is represented by the following formula 4: | 2012-07-26 |
20120190816 | ASYMMETRIC SYNTHESIS OF PEPTIDES - The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR | 2012-07-26 |
20120190817 | ROMIDEPSIN SOLID FORMS AND USES THEREOF - The present disclosure provides solid forms of a compound of formula I. In some embodiments, the present disclosure provides crystalline forms of Compound I. In some embodiments, the present disclosure provides solvate forms of Compound I. In some embodiments, the present disclosure provides amorphous Compound I. | 2012-07-26 |
20120190818 | TRIAZOLE MACROCYCLE SYSTEMS - The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. | 2012-07-26 |
20120190819 | SCAFFOLD POLYPEPTIDES FOR HETEROLOGOUS PEPTIDE DISPLAY - The present invention relates to the use of Stefin A as a scaffold protein for the display of inserted peptides, particularly wherein the Stefin A is a human Stefin A. Several mutations are advantageously made in the wild type stefin A sequence to improve it as a scaffold; preferably the Stefin A comprises a heterologous peptide insertion at the Leu 73 site. Furthermore, preferably the scaffold protein comprises a V48D mutation; preferably the scaffold protein comprises a G4W mutation. Preferably the scaffold comprises Leu73, V48D and G4W mutations. The invention also relates to the scaffold proteins themselves, in particular a stefin A polypeptide having the Leu73, V48D and G4W mutations, such as shown as SEQ ID NO: 1. The invention also relates to a method for identifying binding proteins and to peptide A (RLNKPLPSLPV) and its use in treating yeast infections. | 2012-07-26 |
20120190820 | FACILE AMIDE FORMATION VIA S-NITROSO THIOACID INTERMEDIATES - Provided are methods for forming a reactive S-nitroso thioacid (NTA), comprising nitrosation of a thioacid with a nitrosation reagent. Also provided are methods for: acylating a nucleophile including selective acylation with a high degree of selectivity toward amines over hydroxyls; amide or peptide bond formation; forming a dipeptide or polypeptide; and peptide coupling/ligation, comprising use of thioacid and amine starting materials, wherein the reactions are mediated by very reactive S-nitroso thioacid (NTA) intermediates enabling extremely fast reactions under mild conditions, providing for broad applications. | 2012-07-26 |
20120190821 | RECOMBINANT SOLUBLE FC RECEPTORS - Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycoslyation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host ells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modeling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that an be used to separate and/or enrich antibodies. | 2012-07-26 |
20120190822 | ARTIFICIAL ENTROPIC BRISTLE DOMAIN SEQUENCES AND THEIR USE IN RECOMBINANT PROTEIN PRODUCTION - Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production. | 2012-07-26 |
20120190823 | ARTIFICIAL ENTROPIC BRISTLE DOMAIN SEQUENCES AND THEIR USE IN RECOMBINANT PROTEIN PRODUCTION - Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production. | 2012-07-26 |
20120190824 | METHOD FOR HIGHLY SENSITIVE DETECTION OF PROTEIN-PROTEIN INTERACTION - The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid sequence of amino acid SEQ ID NO: 1 and a second fusion protein comprising the second protein fused with a peptide having an amino acid sequence selected from the group consisting of amino acid SEQ ID NOS: 2 to 6, and allowing the first fusion protein to bind with the second fusion protein to form a complex, and detecting luminescence emitted from the complex. | 2012-07-26 |
20120190825 | ACETYL LYSINE INCORPORATION WITH tRNA SYNTHETASE - The invention relates to a tRNA synthetase capable of binding Nε-acetyl lysine, wherein said synthetase comprises a polypeptide having at least 90% sequence identity to the amino acid sequence of MbPyIRS, and wherein said synthetase comprises a L266M mutation. | 2012-07-26 |
20120190826 | NOVEL ANTIBIOTIC COMPRISING AN ANTIBODY MIMETIC, ITS PREPARATION METHODS AND USES THEREOF - The present invention belongs to field of biology and medicine, and especially relates to a novel antibiotic comprising an antibody mimetic antibody, its preparation methods and uses thereof. A novel antibiotic comprising a antibody mimetic covalently bonded to the carboxyl end of a colicin polypeptide or a channel-forming domain polypeptide of a colicin, wherein said colicin is selected from the group consisting of Colicin E1, Ia, Ib, A, B, N; wherein said antibody mimetic being yielded by fusing two complementarity determining regions (CDRs), V | 2012-07-26 |
20120190827 | Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses - Modified human plasma polypeptides or Fc and uses thereof are provided. | 2012-07-26 |
20120190828 | BIFUNCTIONAL POLYPEPTIDES - A bifunctional polypeptide comprising a specific binding partner for a peptide-MHC epitope, such as an antibody or T cell receptor, and an immune effector, such as an antibody or a cytokine, the immune effector part being linked to the N-terminus of the peptide-MHC binding part. | 2012-07-26 |
20120190829 | ANTIGEN BINDING PROTEINS CAPABLE OF BINDING THYMIC STROMAL LYMPHOPOIETIN - The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders. | 2012-07-26 |
20120190830 | Antibody to Human Zcyto-10 Polypeptide - Antibodies that which specifically bind to mammalian cytokine-like polypeptide, called Zcyto10, are described. The antibodies include monoclonal antibodies and those that where the antibody is an antigen-binding fragment. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets. | 2012-07-26 |
20120190831 | Methods for Steam Flash Extraction of Pectin - Methods are provided for high temperature and short time extraction of pectins from pectin-containing plant materials. Generally described, the method includes mixing the pectin-containing plant material and an acidic aqueous medium to form a mixture; heating the mixture (optionally under pressure) to a target temperature by steam injection; maintaining the mixture under pressure at the target temperature for a time up to about 5 minutes; and flashing the mixture into a flash tank at a pressure from about 0.5 to about 1.2 bar to extract pectin from the pectin-containing plant material. | 2012-07-26 |
20120190832 | LOW-MOLECULAR SERINE PROTEASES INHIBITORS COMPRISING POLYHYDROXY-ALKYL AND POLYHYDROXY-CYCLOALKYL RADICALS - The invention relates to novel amidines and quanidines, the production and use thereof and the use thereof as trypsine-type serine protease competitive inhibitors, especially thrombine and compliment proteases CIs and C1r. The invention also relates to pharmaceutical compositions which contain said compounds as active ingredients, in addition to the use of the compounds as thrombine inhibitors, anticoagulants, compliment inhibitors and anti-inflammatory agents. The novel compositions are characterised by the linkage of a serine protease inhibitor having amidine or guanidine functions with an alkyl radical having two or more hydroxyl functions, whereby said alkyl radical is derived from sugar derivates. Several sugar structural components or components derived from sugar can therefore be linked to each other. Said principle of linking sugar derivates enables oral active compounds to be obtained. | 2012-07-26 |
20120190833 | METHOD OF SELECTION, BY TWO-DIMENSIONAL SEPARATION, OF NUCLEIC ACIDS THAT BIND TO A TARGET WITH HIGH AFFINITY - The invention relates to a method of selection, by two-dimensional separation, of nucleic acids that bind to a target molecule with high affinity from a mixture of nucleic acids, including the following steps: a) subjecting the mixture of nucleic acids to a physico-chemical separation step, thereby obtaining a set of mixed fractions containing the nucleic acids, a run parameter window being associated with every mixed fraction containing the nucleic acids, b) contacting a mixed fraction containing the nucleic acids with the target molecule, thereby obtaining a binding mixture containing nucleic acid/target molecule complexes, c) subjecting the binding mixture from step b) to the same physico-chemical separation step as in step a), thereby selecting nucleic acid/target molecule complexes whose run parameters are outside of the run parameter window. | 2012-07-26 |
20120190834 | APTAMERS TO TISSUE FACTOR PATHWAY INHIBITOR AND THEIR USE AS BLEEDING DISORDER THEREAPEUTICS - The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI. | 2012-07-26 |
20120190835 | HYBRIDIZATION CHAIN REACTION AMPLIFICATION FOR IN SITU IMAGING - The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that comprises a target region able to specifically bind an analyte of interest and an initiator region that is able to initiate polymerization of nucleic acid monomers. After contacting a sample with the probe, labeled monomers are provided that form a tethered polymer. Triggered probes and self-quenching monomers can be used to provide active background suppression. | 2012-07-26 |
20120190836 | PORPHYRANASES, AND USE THEREOF FOR HYDROLYZING POLYSACCHARIDES - The present invention relates to the isolation and to the characterization of two proteins having a novel enzymatic activity, i.e. a porphyranase activity. These proteins are useful for hydrolyzing polysaccharides containing sulfated agaro-colloids and for producing oligo-porphyrans, notably oligo-porphyrans with a defined structure and size. | 2012-07-26 |
20120190837 | Nanoparticles for Manipulation of Biopolymers - Materials and methods for manipulation of biopolymers, including the separation, purification, immobilization, and archival storage of biopolymers is disclosed. | 2012-07-26 |
20120190838 | Labelling Strategies for the Sensitive Detection of Analytes - The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples. | 2012-07-26 |
20120190839 | ACTIVE ESTERIFIED POLYSACCHARIDE AND METHOD FOR PRODUCING SAME - A method for producing an active esterified polysaccharide, the method including: subjecting a carboxy group of a carboxy group-containing polysaccharide and an agent for introducing an electrophilic group, to an esterification reaction, wherein an active esterified polysaccharide is formed; bringing the active esterified polysaccharide into contact with a polyvalent carboxylic acid; and after the active esterified polysaccharide is brought into contact with the polyvalent carboxylic acid, precipitating and collecting the resulting active esterified polysaccharide. | 2012-07-26 |
20120190840 | PROCESS FOR THE PRODUCTION OF ALCOHOLS - The invention provides a process for alcohol production from a cellulosic material wherein a said cellulosic material is subjected to acid hydrolysis to yield an aqueous hydrolysate, said hydrolysate is introduced into a separator at a hydrolysate inlet, an extraction solvent is introduced into said separator at at least two extraction solvent inlets, a residue containing oligosaccharides is removed from said separator at a residue discharge outlet, and acid-containing extraction solvent is removed from said separator at an extraction solvent discharge outlet, wherein removal of said extraction solvent from said separator through said discharge outlet occurs downstream of at least one said extraction solvent inlet and upstream of at least one other said extraction solvent inlet. | 2012-07-26 |
20120190841 | COMPOUND HAVING NEURITE-OUTGROWING ACTIVITY - There is provided a novel compound having neurite-outgrowing activity that is useful for the prevention or the treatment of a neurodegenerative disease. A compound of Formula (I) | 2012-07-26 |
20120190842 | PROCESS FOR THE PREPARATION OF ANTIBIOTIC COMPOUNDS - The present invention relates to a process for the preparation of carbapenem antibiotic compounds, which is useful for intravenous and intramuscular administration. | 2012-07-26 |
20120190843 | AUTOMATED RADIOSYNTHESIS - The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABA | 2012-07-26 |
20120190844 | IONIC LIQUIDS - The invention relates to an ionic liquid composition and a method for preparing the ionic liquid. The ionic liquid comprises a cation containing the Formula I, as herein disclosed, and wherein: n is 2, R | 2012-07-26 |
20120190845 | FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR - The present invention discloses novel compounds of general formula (I) | 2012-07-26 |
20120190846 | MICHAEL ADDITION REACTION PRODUCT AND ACTIVE ENERGY RAY-CURABLE COMPOSITION - The present invention provides a Michael addition reaction product between a specified compound having a group which functions as a Michael donor and a monomer or polymer having a group which functions as a Michael acceptor, a photoinitiator containing the Michael addition reaction product, and an active energy ray-curable composition containing the photoinitiator. The compound having a group functioning as a Michael donor used in the present invention is a phenyl ketone derivative and is characterized by having an amino group or a mercapto group as the group functioning as a Michael donor. | 2012-07-26 |
20120190847 | TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS - Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases. | 2012-07-26 |
20120190848 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES - Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme. | 2012-07-26 |
20120190849 | PROCESSES FOR THE PREPARATION OF VARDENAFIL - The present invention provides processes for the preparation of vardenafil, its pharmaceutically acceptable salts, hydrates and intermediates. | 2012-07-26 |
20120190850 | PROCESS FOR THE PREPARATION OF VALGANCICLOVIR HYDROCHLORIDE - The present invention provides a novel process for the preparation of pure valganciclovir hydrochloride. | 2012-07-26 |
20120190851 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF - Disclosed is a method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and also disclosed is a synthetic intermediate thereof. More specifically disclosed is a method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine represented by general formula (2) (wherein R represents an alkyl group), comprising reacting a t-butyl cyanoacetate derivative represented by general formula (1) (wherein R has the same meaning as described above) in the presence of an acid, and also disclosed is a t-butyl cyanoacetate derivative represented by general formula (1) (wherein R represents an alkylgroup). | 2012-07-26 |
20120190852 | MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA - The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): | 2012-07-26 |
20120190853 | BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds of structural formula (I) or (III): | 2012-07-26 |
20120190854 | Hydroamination of Alkenes - A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. | 2012-07-26 |
20120190855 | Method and Substances for the Preparation of N-Substituted Pyridinium Compounds - Methods for the synthesis of N-substituted carboxylated pyridinium compounds by reaction of a pentamethine precursor with a primary amine are provided. In this reaction an N-substituted alkoxycarbonyl pyridinium heterocycle is formed. | 2012-07-26 |
20120190856 | PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS - The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid in substantially free form (Compound 1). | 2012-07-26 |
20120190857 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES - 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling. | 2012-07-26 |
20120190858 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES - 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, reaction with hydrazine, halogenation, hydrolysis and esterification, and transition metal assisted coupling. | 2012-07-26 |
20120190859 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling. | 2012-07-26 |
20120190860 | PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES - 4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinates by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation and transition metal assisted coupling. | 2012-07-26 |
20120190861 | Levodopa Prodrugs, and Compositions and Uses Thereof - Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. | 2012-07-26 |
20120190862 | Methods for Preparing Diazonamides - This invention relates to novel macrocyclic lactams intermediates useful for the preparation of diazonamide analogs. This invention also relates to a novel electrochemical oxidative cyclization for the preparation of such macrocyclic lactams, and their further elucidation to provide diazonamide analogs. | 2012-07-26 |
20120190863 | PROCESS FOR PREPARATION OF LOW MOLECULAR WEIGHT MOLYBDENUM SUCCINIMIDE COMPLEXES - Disclosed is a process for preparing a molybdated succinimide complex, the process comprising:
| 2012-07-26 |
20120190864 | PROCESS FOR PREPARATION OF HIGH MOLECULAR WEIGHT MOLYBDENUM SUCCINIMIDE COMPLEXES - Disclosed is a process for preparing a molybdated succinimide complex, the process comprising:
| 2012-07-26 |
20120190865 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives - The present invention relates to a novel process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives and to novel intermediates and to a process for their preparation. | 2012-07-26 |
20120190866 | ANTIVIRAL COMPOUNDS - The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. | 2012-07-26 |
20120190867 | PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE - A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) | 2012-07-26 |
20120190868 | SUBSTITUTED BENZOCHALCOGENOACENE COMPOUND, THIN FILM COMPRISING THE COMPOUND, AND ORGANIC SEMICONDUCTOR DEVICE INCLUDING THE THIN FILM - Provided are a novel compound suitable as an organic semiconductor material, the compound being a substituted benzochalcogenoacene compound represented by the formula (1), a thin film comprising the compound, and an organic semiconductor device having the thin film as a component. In the formula (1), each E independently represents a sulfur or selenium atom, and R | 2012-07-26 |
20120190869 | OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL DERIVATIVE AND ITS USE AS INTERMEDIATE FOR PREPARATION OF (S)-(-)-3-METHYLAMINO-1-(-2-THIENYL)PROPAN-1-OL - The present invention provides an (S)-methylhydroxylaminopropanol compound and the (S)-methylhydroxylaminopropanol compound of the present invention is used as an intermediate for preparation of (S)-(−)-3-methylamino-1-(2-thienyl)propan-1-ol, which is an intermediate for preparation of (S)-(+)-N-methyl-3-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate. The present invention also provides a process for preparing (S)-(+3-methylamino-1-(2-thienyl)propan-1-ol with higher yield and lower cost, wherein the (S)-methylhydroxylaminopropanol compound is used as an intermediate. | 2012-07-26 |
20120190870 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 2012-07-26 |
20120190871 | TRITERPENOID COMPOSITION OF ANTRODIA CINNAMOMEA, PREPARATION AND ANALYSIS METHOD THEREOF - Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of | 2012-07-26 |
20120190872 | PROCESS FOR THE RECOVERY OF OLEAGINOUS COMPOUNDS FROM BIOMASS - Disclosed herein are methods and processes for the recovery of oleaginous compounds from biomass and in particular biomass comprises photosynthetic microorganisms. Also disclosure are oleaginous compounds Obtained using the disclosed methods. | 2012-07-26 |
20120190873 | PROCESS FOR THE PREPARATION OF PALLADIUM (I) TRI-TERT-BUTYLPHOSPHINE BROMIDE DIMER - The present invention provides a process for the preparation of a complex of formula (I) comprising the steps of: (a) mixing Pd(diolefin)Br | 2012-07-26 |
20120190874 | METAL COMPLEXES HAVING DUAL HISTONE DEACETYLASE INHIBITORY AND DNA-BINDING ACTIVITY - Compounds comprising a metal complex having the structure [X—Y—Z-M | 2012-07-26 |
20120190875 | COMPOSITIONS AND METHODS FOR STEREOSELECTIVE ALDEHYDE ALLYLATION AND CROTYLATION - Compositions and methods for practical, stereoselective allylation and crotylation for aldehyde substrates are described. The compositions and methods comprise reagents for allylation and/or crotylation and acids. In some embodiments, the reagents and acids are pre-mixed. | 2012-07-26 |
20120190876 | Method Of Producing An Aminoalkylalkoxysilane - A method of preparing an aminoalkylalkoxysilane, the method comprising reacting a haloalkylalkoxysilane with ammonia in a high pressure reactor for an amount of time sufficient to consume from 20 to 99.99% (w/w) of the haloalkylalkoxysilane and form an aminoalkylalkoxysilane; venting ammonia from the reactor to give a mixture comprising the aminoalkylalkoxysilane, unreacted haloalkylalkoxysilane, and an ammonium halide; and treating the mixture with a primary amine to form an N-substituted aminoalkylalkoxysilane. | 2012-07-26 |
20120190877 | METHOD FOR THE MANUFACTURE OF DIALKYLPHOSPHITES - A method for the manufacture of dialkyl phosphites is disclosed wherein a P—O component containing from 1 to 6 P—O—P bonds in the molecule is reacted with an alcohol and a carboxylic acid ester having from 1 to 6 carbon atoms in the alkyl group and from 5 to 20 carbon atoms in the esterifying alkyl group of the ester. The dialkyl phosphites are formed under simultaneous removal by distillation of the carboxylic acid formed. | 2012-07-26 |
20120190878 | PROCESS FOR PRODUCING DIPHENYL CARBONATE - Processes for producing diaryl carbonates are disclosed, where such processes may provide for the production of diaryl carbonates from green house gases, such as carbon dioxide. The processes disclosed advantageously integrate diethyl carbonate and diaryl carbonate production, eliminating the need for solvent-based extractive distillation, as is commonly required when producing diaryl carbonates from dimethyl carbonate, providing for the integration of separation equipment and raw material usage, and reducing the operating and capital requirements for such processes. In some embodiments, processes disclosed herein may be operated essentially closed-loop with respect to ethanol usage, for example. | 2012-07-26 |
20120190879 | HYDROCHLORINATION OF ELECTRON-DEFICIENT ALKENES - The present invention pertains to a method for the hydrochlorination of electron deficient alkenes, particularly alkenes having the functional groups COOH, CONH | 2012-07-26 |
20120190881 | INDANE DERIVATIVES FOR USE AS INTERMEDIATES - A compound of Formula (4), wherein each X is independently fluorine or chlorine; n is 1 or 2; R | 2012-07-26 |
20120190882 | EFFICIENT ISOLATION OF CIMIRACEMATE A, AND METHODS OF USE - A method for isolating cimiracemate A from a | 2012-07-26 |
20120190883 | PROCESS FOR PREPARING POLYOL ESTERS - The present invention relates to a process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarbocxylic acids having 3 to 20 carbon atoms, the reaction taking place in the presence of a Lewis acid comprising at least one element from groups 4 to 14 of the Periodic Table of the Elements as catalyst, and in the presence of an adsorbent, the reaction product being subjected subsequently to a steam treatment. | 2012-07-26 |
20120190884 | METHOD FOR PREPARING DIFLUOROACETIC ACID ESTERS - A method for preparing difluoroacetic acid esters is described. The method can include reacting difluoroacetyl fluorine with an aliphatic or cycloaliphatic alcohol in the presence of a heterogeneous mineral base. | 2012-07-26 |
20120190885 | PROCESS FOR PREPARING AN ESTER - A process for preparing an ester of formula (I): | 2012-07-26 |
20120190886 | COMPOSITION FOR LOWERING BLOOD URIC ACID LEVEL - A composition for lowering a blood uric acid level is characterized by comprising taurine as an active ingredient. | 2012-07-26 |
20120190887 | Processes for preparing pharmaceutical grade melphalans from industrial grade reactants - A four stage inexpensive method of preparing pharmaceutical grade Melphalans of Melphalan 2-HCl, Melphalan HCl and Melphalan by: | 2012-07-26 |
20120190888 | TREPROSTINIL PRODUCTION - The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil. | 2012-07-26 |
20120190889 | PROCESS FOR PREPARATION OF A CARBOXYLIC ACID SALT BY DEHYDROGENATION OF A PRIMARY ALCOHOL - This invention is directed a process for preparation of a carboxylic acid salt by dehydrogenation of a primary alcohol. The invention is also directed to a catalyst for dehydrogenating primary alcohols. | 2012-07-26 |
20120190890 | METHOD FOR PRODUCING BIORESOURCED ACRYLIC ACID FROM GLYCEROL - An aim of the present invention is to produce, from glycerol, a bioresourced acrylic acid, that is to say an acrylic acid essentially based on a carbon source of natural origin, corresponding to a degree of purity corresponding to the requirements of the users. | 2012-07-26 |
20120190891 | SYSTEMS AND METHODS FOR PROCESSING LIPID FEEDSTOCKS - Embodiments of the invention include processing lipid feedstocks into various products. In an embodiment, the invention includes a method of processing a lipid feedstock including combining the lipid feedstock with water to form a reaction mixture; and contacting the reaction mixture with a catalyst, the catalyst including a metal oxide. Methods can be used to form polyols, diols, and carboxylic acids, amongst others. Other embodiments are also included herein. | 2012-07-26 |
20120190892 | PROCESS FOR THE PREPARATION OF A HALOGENOACETYL FLUORIDE AND ITS DERIVATIVES - The present invention relates to a method for preparing a halogenoacetyl fluoride and the derivatives thereof. The inventive method for preparing a halogenoacetyl fluoride acid is characterised in that said method includes: a step of preparing a halogenoacetyl halide by photo-oxidation of a halogenoethylene compound in conditions such that the transformation rate of the halogenoethylene compound into halogenoacetyl halide is no higher than 80%, producing a reaction mixture essentially including halogenoacetyl halide and the excess halogenoethylene compound; a step of partial fluorination of the mixture obtained by reacting the latter with hydrofluoric acid suitable for obtaining a mixture of halogenoacetyl fluoride and the excess halogenoethylene compound; a step of separating the halogenoacetyl fluoride and the excess halogenoethylene compound. The invention can be used, specifically, for preparing the trichloroacetyl fluoride used as an intermediate species in the production of trifluoroacetic acid. | 2012-07-26 |
20120190893 | Tertiary Amine Salt Additives for Hydrate Control - New tertiary amine salts are useful as gas hydrate inhibitors in oil and gas production and transportation. These tertiary amine salts give very good separation from an emulsion, are economic and have reduced toxicity concerns. | 2012-07-26 |