30th week of 2013 patent applcation highlights part 39 |
Patent application number | Title | Published |
20130189638 | SELF-LIGATING ORTHODONTIC BRACKET - An orthodontic bracket having a bracket body configured to be mounted to a tooth includes an archwire slot having a base surface defining a base plane and a slide engagement track defining a translation plane. The translation plane is angled with respect to the base plane. A ligating slide is engaged with the slide engagement track of the bracket body and movable along the slide engagement track and parallel to the translation plane between an opened position, in which an archwire is insertable into the archwire slot, and a closed position, in which the archwire is retained within the archwire slot. The translation plane is angled with respect to the base plane so as to prevent the ligating slide from contacting the gingiva surrounding the tooth when the ligating slide is moved to the opened position. | 2013-07-25 |
20130189639 | Self Ligating Orthodontic Bracket Having a Rotatable Member - The present disclosure is directed, at least in part, to a self ligating orthodontic bracket having a rotatable member for securing an archwire within a slot of the bracket. Embodiments of the orthodontic bracket disclosed herein include a bracket body containing the archwire slot as well as tie wings for attaching various orthodontic devices (e.g., elastomeric bands) to the bracket. The rotatable member is rotatable in a first direction (e.g., counter clockwise) relative to a body of the bracket for securing or locking the archwire within the slot, and for rotating in an opposite direction (e.g., a clockwise direction) relative to the bracket body for unsecuring or unlocking the archwire so that it is substantially unrestrained from exiting the slot. | 2013-07-25 |
20130189640 | Orthodontic Supporting Member - A support member for correcting tooth irregularities is provided. The support member includes: a main body that extends in a longitudinal direction and includes a hook portion formed on an end portion thereof; and a plurality of leg portions each of which extends in a radial direction from a central portion of the main body and has a through-hole formed in an end portion thereof, wherein each of the plurality of leg portions is obliquely formed with respect to a line perpendicular to the longitudinal direction of the main body. The support member may be simply fixed to a palatine bone by fixing a fixing screw to the palatine bone without cutting a mucus membrane and may maintain a stable fixed state because the plurality of leg portions are fixed in an area other than a midpalatal suture area. | 2013-07-25 |
20130189641 | COMPOSITION AND METHOD FOR DETECTING OF MINERALISATION - A detection device comprises a proximal end and a light-transmitting portion, wherein the proximal end comprises a light detection means and the light-transmitting portion comprises means for transmitting light along a path from a surface of interest to the light detection means. The light transmitting portion is optimised for use in detecting a low light signal generated by fluorescence or luminescence in conditions of ambient light. The device is adapted to detect the presence of a disclosing substance which has been applied to a surface of interest. | 2013-07-25 |
20130189642 | LIGHT IRRADIATION DEVICE FOR DENTAL IMPLANTS - A light irradiation device for dental implants, which is capable of reliably performing a required ultraviolet ray irradiation treatment to screw type dental implants, is provided. The light irradiation device for dental implants irradiates screw type dental implants with ultraviolet rays wherein each of the screw type implants has a screw part comprising a spiral protrusion. The light irradiation device comprises a casing, a stage that is provided within the casing, in which the plurality of dental implants are disposed and held so as to be aligned in one direction, and an ultraviolet ray irradiation lamp that is disposed within the casing, wherein the entire surface of the protrusion that forms the screw part of each of the plurality of dental implants held on the stage is irradiated with the ultraviolet rays emitted from the ultraviolet ray irradiation lamp. | 2013-07-25 |
20130189643 | Dental Needle and Sliding-Sheath Capping System - An improved safety needle cap for disposable needles used on dental syringes, or on syringes of similar design, that may be removed and replaced without risk of a needle stick injury. This is accomplished by fitting a needle cap to the needle hub so that it can slide down over the syringe body and lock in place while in use. The cap will then slide back over the needle and lock in place, covering the needle cannula while not in use. In this way the user's digits are continuously below the needle, decreasing the chance for puncture. The device will use a single cap that will cover both cannulas of a double sided needle, rather than the dual cap system commonly used. | 2013-07-25 |
20130189644 | Multi-Planar Pre-Curved Rotary Endodontic File - An improved rotary endodontic file includes a multi-planar pre-curved apical portion having a first and a second curvature. The pre-curved apical portion begins at about one-third to one-quarter of the working length as measured from the tip end of the endodontic instrument. The first and second curvature permit the file to continually search and engage the walls of a tooth root canal in a forced inside-forced outside manner. As the file works its way down, it breaks free of any ledges encountered, probes lateral- and delta-type openings, and does not allow the file to stray from the curvature of the canal. | 2013-07-25 |
20130189645 | Medical membrane, in particular dental membrane and tooth implant with such a membrane - A medical membrane, in particular a dental membrane for regeneration and/or inducing of tissue, in particular of periodontal tissue and for use in direct contact with bone tissue or connective tissue along with a tooth implant. | 2013-07-25 |
20130189646 | METHOD AND APPARATUS FOR RECORDING SPATIAL GINGIVAL SOFT TISSUE RELATIONSHIP TO IMPLANT PLACEMENT WITHIN ALVEOLAR BONE FOR IMMEDIATE-IMPLANT PLACEMENT - A dental implant has a hollow shell with outer bio-compatible surface for engaging a soft tissue socket left in gingival tissue after a tooth has been extracted, to promote healing. The shell tapers outwardly from a first to a second perimeter, the second perimeter being asymmetrically scalloped with opposite distal and mesial peaks and opposite lingual and facial valleys between the peaks. A dental implant in the bone socket left after tooth extraction is rigidly connected to a temporary post, the temporary post extending in the shell. The shell engages against the soft tissue socket without gaps and without requiring alignment between the shell and implant axes. | 2013-07-25 |
20130189647 | DENTAL ARTICULATOR - A dental articulator is provided in which at least one of the two arms thereof has a base member that is articulated with respect to a bracket element onto which a dental model may be mounted, allowing independent movement of the dental model with respect to the pivot axis hingedly linking the arms. | 2013-07-25 |
20130189648 | DEVICE AND METHOD FOR REMOVING DENTAL POSTS - A dental post removal device having a hollow tubular structure having a sidewall and two open ends, and engaging features formed on the sidewall, and a fixing structure formed on the hollow tubular structure adapted for pulling the hollow tubular structure. The engaging features can be a series of openings formed through the sidewall of the hollow tubular structure, and/or the inner wall surfaces of the sidewall that at least one of is scored, textured, dimpled, and/or coated with a high adhesion material. The engaging features being adapted to improve adhesion to a composite resin, cement and/or adhesives to be placed in the hollow tubular structure. | 2013-07-25 |
20130189649 | DRIVER QUALITY ASSESSMENT FOR DRIVER EDUCATION - A driver performance evaluation and apparatus includes means for generating first data stream representing driver actions, a second data stream representing vehicle movements, a filtering function to eliminate short term actions in both data streams, the generation of a raw score which is independent of timing and the adjustment of the raw score based on a comparison of actual driver action timing to an ideal timing sequence to provide a final score which is an indication of driver performance/proficiency. | 2013-07-25 |
20130189650 | BEAD AND PHOTO CRAFT AND RELATED SYSTEM AND METHOD - A method of providing a craft kit involves providing a kit including a frame with a window and a collection of beads presenting a plurality of colors and a pre-selected, fixed number of beads of each color. After providing the craft kit an image is received from a user. A bead template is generated by assigning a bead color to each of a plurality of bead positions on the template document to create a representation of the image using only beads from the collection of beads in the craft kit, and including a bead color indicator in each of said positions on the template document corresponding to the assigned bead color. Once the bead template document is created, it is transferred to the user to enable assembly of a bead array on the frame presenting the representation of the image. | 2013-07-25 |
20130189651 | DRAW DOWN PAINT SAMPLE CARD AND METHODS - Draw down paint sample cards, methods of making draw down paint sample cards from fresh paint using draw down paint sample cards, and systems including draw down paint sample cards and draw down bars sized for use with the draw down paint sample cards. The draw down paint sample cards may include a first side perforated line adjacent to a first side edge, a second side perforated line adjacent to a second side edge, a bottom perforated line adjacent to a bottom edge, and optionally a top perforated line adjacent to a top edge. After application of a fresh paint sample to the draw down card using a draw down bar, the perforated lines allow one or more of the unpainted edges of the draw down paint sample card to be removed to create a final paint sample card with paint extending to one or more of the edges. | 2013-07-25 |
20130189652 | METHOD OF LINGUISTIC PROFILING - In order to define or measure the language proficiency of a person, particularly the degree of flawlessness in the pronunciation, and/or to find out the linguistic background and identity of a person, the person's speech is compared with a selected reference language. This is achieved by applying autocorrelation and/or pattern recognition and/or signal processing and/or other corresponding methods for identifying and registering such sound elements and features that are typical of the reference language and occur repeatedly in the reference language speech sample. On the basis of the obtained linguistic profile of the reference language, corresponding sound elements and features are searched in the speech of the person, and there is calculated how many of the sound elements and features of the reference language linguistic profile the person substitutes with such sound elements or features that deviate from the reference language, and the substitute sound elements and features are defined. | 2013-07-25 |
20130189653 | SET OF BLOCKS WITH BEGINNING, MIDDLE AND ENDING BLOCKS HAVING CONNECTORS AND ALPHABETICAL INDICIA - There is provided a set of blocks including a plurality of beginning, middle and ending blocks. The blocks each have an indicia face with alphabetical indicia, a front end and a rear end. The middle block front end includes a first connector having a first gender type. The rear end includes a second connector having a first gender type. The beginning block rear end includes a beginning block primary connector having a second gender type. The beginning block primary connector is engageable with a first connector. The beginning block primary connector is not engageable with a second connector. The ending block front end includes an ending block primary connector having a second gender type. The ending block primary connector is engageable with a second connector. The ending block primary connector is not being engageable with a first connector. | 2013-07-25 |
20130189654 | VOCABULARY LEARNING SYSTEM AND METHOD - A computerized system and method of teaching vocabulary to a student includes an application that provides predetermined word lists. A teacher or instructor may also add words to the word database based on a user's curriculum, cross-curriculum or words of interest. The words in the word database are utilized to automatically create an individualized vocabulary assignment. The user is instructed to learn the new vocabulary words by breaking the words into their suffixes, prefixes, roots and word origin and history. The student is encouraged to create a word history or etymology of the word to understand the history, the language of origin, and the language from which the word is borrowed. The student is then instructed to use the vocabulary word(s) in a sentence. The teacher, instructor or an online tutor monitors the completion of the various assignments by the student and also monitors how well the assignments are performed. | 2013-07-25 |
20130189655 | Pocket Tech - Pocket Tech is an Android app that will show MRI technologists how to scan every body part In MRI the tech must know how to image in all imaging planes, and this app will show them how to do it. Very useful for novice or even the experienced tech. | 2013-07-25 |
20130189656 | SIMULATOR FOR SKILL-ORIENTED TRAINING - A simulator for skill-oriented training is presented. The simulator includes a platform having a sensor and provides an immersive virtual training environment. The simulator includes a display unit worn by the operator. The unit includes a camera, a speaker and a unit sensor. The camera and the speaker provide visual and audio output to the operator. The simulator includes a controller and a data processing system. The controller includes a sensor. The sensors cooperate to provide to the processing system signals representing spatial positioning, angular orientation and movement data of the controller relative to the platform and a work piece. In response, the processing system renders the work piece, a virtual coating spray pattern, a virtual coating as applied to the work piece and performance guidance in the training environment. | 2013-07-25 |
20130189657 | VIRTUAL REALITY GTAW AND PIPE WELDING SIMULATOR AND SETUP - A simulator facilitating virtual welding activity. The simulator may include a logic processor based subsystem operable to generate an interactive welding environment in virtual reality space that emulates welding activity by simulating a virtual weld puddle having dynamic, real time molten metal fluidity and heat dissipation characteristics, responsive to performing a simulated welding activity in real time. The simulator may include a foot pedal device in operative communication with the logic processor based subsystem and configured to affect a characteristic of the virtual weld puddle in real time, responsive to user control of the foot pedal device. The simulator may be configured to track the movements of a mock welding tool and a mock filler wire and determine interaction between the virtual weld puddle, a corresponding virtual welding tool, and a corresponding filler wire in virtual reality space that would result in the welding tool becoming contaminated. | 2013-07-25 |
20130189658 | SYSTEMS AND METHODS PROVIDING ENHANCED EDUCATION AND TRAINING IN A VIRTUAL REALITY ENVIRONMENT - Virtual reality arc welding systems that provide virtual reality simulations for training purposes. Virtual reality welding systems to aid in training welding students may provide intelligent connections to web sites on the internet, overlays of ideal weld puddles, recommended corrective actions based on virtual testing results, simulations of virtual environments with safety hazards, and simulations of relationships between improperly set welding parameters and weld defects and discontinuities. | 2013-07-25 |
20130189659 | Appraisal Process Framework for Scrum Projects - A method for computing appraisal information concerning an individual which comprises receiving, by a server, questionnaire responses evaluating the individual from a plurality of client devices, the questionnaire responses including (i) self evaluation responses, by the individual, to a plurality of questions and (ii) peer evaluation responses, by peers of the individual, to the plurality of questions; computing appraisal information from the questionnaire responses, by: (i) for each question, computing an aggregate peer evaluation from peer evaluation responses corresponding to that question; and (ii) for each question, computing a metric indicative of a discrepancy between a self perception of the individual's performance as indicated in the self evaluation response corresponding to that question and a peer perception of the individual's performance as indicated in the aggregate peer evaluation corresponding to that question, the appraisal information including the computed metric. | 2013-07-25 |
20130189660 | METHODS AND SYSTEMS FOR ASSESSING AND DEVELOPING THE MENTAL ACUITY AND BEHAVIOR OF A PERSON - Methods and systems for assessing and developing the mental acuity and behavior of a person are provided. A method of assessing mental acuity and character can include using a computer system to executing user interactive exercises involving the use of at least one of visual acuity skills, operational thinking skills and behavioral skills of the user. During execution of each user interactive exercise, the computer system can receive user inputs including body movement of a user and touch interaction between the user and a user interface in communication with the computer system. The computer system can measure and record performance data related to the timing and accuracy of the user inputs in each user interactive exercise. The computer system can processes the performance data to generate scores in assessment categories that provide measurements of at least one of the visual acuity skills, operational thinking skills and behavioral skills of the user. Computer systems and memory devices for implementing the disclosed methods are also disclosed. | 2013-07-25 |
20130189661 | SCORING HUMOR REACTIONS TO DIGITAL MEDIA - As an individual or a group of individuals view various types of humor, a webcam, using video capture, collects mental state data from the individual or individuals. The webcam data is analyzed to determine physiological data, facial data, and actigraphy data. Further, the direct collection of physiological data—electrodermal activity, heart rate, heart rate variation, skin temperature, and respiration—from an individual or individuals complements the webcam data. Analysis of this mental state data allows for the accurate comprehension of individual humor preferences and allows the individual's humor preferences to be used by the system to recommend humorous material based on these preferences. | 2013-07-25 |
20130189662 | PROGRAMMABLE EXERCISE INSTRUCTION DEVICE - A programmable workout device for leading a user in a workout. A user interface is attached to a housing. A microprocessor is in operative connection with the user interface and is installed within the housing. A memory unit is in operative communication with the microprocessor and is installed in the housing. A database is stored in the memory unit. The database includes a bank of prerecorded workout routines. The microprocessor and memory unit operate in conjunction to randomly present the prerecorded workout routines to a user who is exercising so that the user can follow the workout routine. | 2013-07-25 |
20130189663 | MEDICAL TRAINING SYSTEMS AND METHODS - Simulation systems and methods may enable virtual imaging. A data processing unit may receive data from a calibration unit indicating a position and/or orientation of a position and orientation sensor relative to a physical model. The data processing unit may also receive data from the position and orientation sensor indicating a position and/or orientation of the physical model. The data processing unit may generate a virtual image using the data from the position and orientation sensor and the data from the calibration unit. The data processing unit may render the virtual image to a display. | 2013-07-25 |
20130189664 | METHOD AND APPARATUS FOR PROVIDING MEDIA STREAM SWITCHING BASED INTERACTIVE LECTURE SERVICE, AND RECEIVING METHOD AND APPARATUS - Disclosed herein are a method and an apparatus for controlling an interactive lecture service capable of performing questions and answers during a lecture without using a media mixer. A method for providing a media stream switching based interactive lecture service, includes: receiving a right to speak request from at least one student terminal by a lecturer terminal; assigning the right to speak to a specific student terminal in response to the right to speak request and receiving at least one of the question video and voice of the specific student terminal, by the lecturer terminal; and transmitting at least one of the receiving question video and voice of the specific student terminal to a terminal included in a lecture session by the lecturer terminal. | 2013-07-25 |
20130189665 | METHODS, COMPUTER-READABLE STORAGE MEDIA, AND APPARATUSES FOR DISTIRBUTION OF EDUCATIONAL COURSE CONTENT - A method of distributing educational course content to a user of a first computer according to an illustrative embodiment involves causing the first computer to present educational information retrieved from a first at least one computer-readable storage medium comprising the educational information stored thereon in association with one of a first plurality of educational modules, the educational information presented by the first computer and stored on the first at least one computer-readable storage medium in association with the one of the first plurality of educational modules comprising at least one question, instructional information, and at least one explanation for a respective correct answer to a respective one of the at least one question. Causing the first computer to present the instructional information involves causing the first computer to present at least a portion of the instructional information while the at least one question is being presented by the first computer. | 2013-07-25 |
20130189666 | SYSTEM AND METHOD FOR REAL TIME TRACKING OF STUDENT PERFORMANCE BASED ON STATE EDUCATIONAL STANDARDS - A system for providing feedback on educational standards within schools includes an interface providing access to a plurality of established educational standards which may be downloaded into a database of the system. A plurality of control modules enables a user to establish educational programs specifically associated with at least one of the downloaded established educational standards and receive feedback on student performance. Real time reports on student performance are provided responsive to the received feedback on student performance. | 2013-07-25 |
20130189667 | METHOD AND APPARATUS FOR INTERACTIVE, COMPUTER-BASED, AUTOMATICALLY ADAPTABLE LEARNING - A method and apparatus interactive, computer-based, automatically adaptable education. The apparatus includes a screen visible to one or more students in a classroom and capable of accessing a network; a central computer capable of accessing the network and capable of transmitting a lesson over the network; and at least one educational module capable of accessing the network, the at least one educational module being assigned to a student, the at least one educational module being capable of receiving from the assigned student and transmitting to the central computer a response by the assigned student to the lesson, the central computer being capable of receiving the response, the central computer being further capable, based on the response, of interactively and automatically selecting and transmitting over the network for viewing on the screen, a new lesson. | 2013-07-25 |
20130189668 | BLOOD SEPARATION AND CONCENTRATION SYSTEM - This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator. | 2013-07-25 |
20130189670 | Protein-Free Gamete and Embryo Handling and culture Media Products - This invention discloses a substantially protein-free cell culture solution for assisted reproductive technologies and methods of use thereof. | 2013-07-25 |
20130189671 | Cell Culture System and Method of Use Thereof - The present invention is based in part on the discovery of significant improvements to cell culture systems and methods in terms of utility and range of application. The system allows for culture of cells in one or more defined spaces within a culture chamber defined by one or more spaced opposing surfaces to provide significant advantages over previously described culture methods. The system includes a chamber for receiving a fluid culture medium; a first surface and one or more second surfaces defining one or more spaces in the chamber; and one or more cells constrained within the one or more spaces. The second surface includes at least one opening for passage of a substance into the culture space. | 2013-07-25 |
20130189672 | Assay Device Having Multiple Reagent Cells - An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone. The reagent zone includes at least two reagent cells containing a reagent material and arranged in the reagent zone such that each reagent cell experiences substantially the same flow conditions of sample from the sample zone. The reagent cells divide the sample flow from the sample zone into multiple flow streams. Also includes are: one or more flow control elements disposed downstream from the reagent zone which combine the multiple flow streams into fewer flow streams; a detection zone in fluid communication with the reagent zone; and a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. The sample addition zone, the detection zone and the wicking zone define a fluid flow path. | 2013-07-25 |
20130189673 | Assay Device Having Controllable Sample Size - Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume. | 2013-07-25 |
20130189674 | Methods and Compositions for Enriching Either Target Polynucleotides or Non-Target Polynucleotides from a Mixture of Target and Non-Target Polynucleotides - Compositions and methods are provided for enriching mitochondrial DNA and optionally chloroplast DNA from eukaryotic cells in a simple rapid method that provides greater than 100 fold enrichment. Affinity protein-coated substrate in a buffer is used to efficiently bind chromosomal DNA and thereby remove it from the buffer. Mitochondrial sequencing reads reveal that non-biased sequence selection providing representation of a substantial proportion of mitochondrial DNA in the eukaryotic cells analyzed. | 2013-07-25 |
20130189675 | Assay to Capture and Detect Circulating Multiple Myeloma Cells from Blood - The invention includes methods for isolating circulating multiple myeloma cells as well as method of treating patients suspected of having diseases of abnormal plasma cells. | 2013-07-25 |
20130189676 | USE OF GENETIC MODIFICATIONS IN HUMAN GENE CHK1 WHICH CODES FOR CHECKPOINT KINASE 1 - The invention relates to an in vitro method for predicting disease risks, progression of diseases, drug risks, success of treatment and for finding drug targets by looking for one or more genetic modifications in the promoter region of the CHK1 (CHEK1) gene on human chromosome 11q23, the genetic modifications being a substitution thymine for guanine in position −1143 in the promoter of CHK1, of thymine for cytosine in position −1400, a substitution of cytosine for thymine in position −1453 or an insertion of one cytosine in position −1454 and the genetic modifications being detected individually or in any combinations by way of known methods. | 2013-07-25 |
20130189677 | ABC terpenoid transporters and methods of using the same - Provided are ATP-binding cassette transporters (ABC transporters). More specifically, the present disclosure relates to ABC terpenoid transporters, nucleic acid sequences, amino acids, proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof. | 2013-07-25 |
20130189678 | MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) PROMOTER POLYMORPHISM IN INFLAMMATORY DISEASE - Describe herein is a novel CATT-tetranucleotide repeat polymorphism at position −817 of the human Mif that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6, 7, or 8-CATT repeat units. Of these, the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro. The presence of the low expressing, 5-CATT repeat allele correlated with low disease severity in a cohort of rheumatoid arthritis patients. Methods, compositions and apparatus for detecting this CATT-tetranucleotide repeat polymorphism at position −817 of the human Mif gene, and for using same for assessing predisposition to severe inflammatory disease, are also disclosed. | 2013-07-25 |
20130189679 | PSEUDOGENES AND USES THEREOF - The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to pseudogenes as diagnostic markers and clinical targets for prostate cancer. | 2013-07-25 |
20130189680 | POLYMER STABILIZATION OF CHROMOGEN SOLUTIONS - Disclosed embodiments concern a composition comprising DAB chromogen, and/or derivative thereof, a stabilizer, and polymer capable of preventing or reducing DAB precipitation relative to a composition that does not comprise the polymer. Also disclosed herein is a method for using the disclosed composition and embodiments of a kit. | 2013-07-25 |
20130189681 | COTTON EVENT pDAB4468.19.10.3 DETECTION METHOD - Cotton event pDAB4468.19.10.3 comprises gene expression cassettes which contain genes encoding aad-12 and pat, affording herbicide tolerance to cotton crops containing the event, and enabling methods for crop protection. Embodiments of the subject invention provide polynucleotide-related event detection methods. | 2013-07-25 |
20130189682 | COTTON EVENT pDAB4468.18.07.1 DETECTION METHOD - Cotton event pDAB4468.18.07.1 comprises gene expression cassettes which contain genes encoding aad-12 and pat, affording herbicide tolerance to cotton crops containing the event, and enabling methods for crop protection. Embodiments of the subject invention provide polynucleotide-related event detection methods. | 2013-07-25 |
20130189683 | IDENTIFICATION OF A JAK2 MUTATION INVOLVED IN VAQUEZ POLYGLOBULIA - The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group. | 2013-07-25 |
20130189684 | QUANTIFICATION OF CELL-SPECIFIC NUCLEIC ACID MARKERS - The technology relates in part to selection, quantification and use of particular nucleic acid markers. In some embodiments, such markers are particular epigenetic markers, and sometimes each marker is a particular methylation state of a nucleic acid locus. | 2013-07-25 |
20130189685 | Method for Improved Diagnosis of Dysplasias - The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterising the proliferation properties of the respective cell. The characterisation of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens. | 2013-07-25 |
20130189686 | Method for Improved Diagnosis of Dysplasias - The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK | 2013-07-25 |
20130189687 | METHOD FOR MEASURING PYROPHOSPHORIC ACID AND SNP TYPING METHOD - One general aspect provides a method for detecting pyrophosphoric acid in a sample solution with high sensitivity and high accuracy by a small sensor element, and an SNP typing method. In the general aspect, a sample solution having a volume of more than that of a measurement cavity is supplied to the measurement cavity through a flow path, so as to expose a droplet from the opening. The droplet has a shape of sphere. The shape of the sphere is maintained by surface tension generated on a surface of the droplet. At least part of the sample solution contained in the droplet is evaporated so as to increase a concentration of pyrophosphoric acid in the sample solution included in the measurement cavity. | 2013-07-25 |
20130189688 | RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample. | 2013-07-25 |
20130189689 | RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample. | 2013-07-25 |
20130189690 | SCN5A Splice Variants for Use in Methods Relating to Sudden Cardiac Death and Need for Implanted Cardiac Defibrillators - Provided herein are methods of determining a subject's need for an implanted cardiac defibrillator, methods of determining a subject's risk for sudden cardiac death (SCD), arrhythmias, or heart failure, methods of determining a subject's need for an anti-arrhythmic agent, e.g., a sodium channel blocker, and methods of reducing risk of SCD in a subject. In exemplary embodiments, each of the methods comprise the step of determining a ratio, R | 2013-07-25 |
20130189691 | IDENTIFICATION OF ISOLATED GENOMIC NUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN CLUSTER OF DIFFERENTIATION ANTIGEN 81 AND VARIANTS THEREOF - Provided herein are isolated genomic polynucleotide fragments from the p15 arm of chromosome 11 and methods of use. | 2013-07-25 |
20130189692 | Single Nucleotide Polymorphisms (SNPs) in Genes Associated With Inflammatory Diseases - The present disclosure describes the identification of single nucleotide polymorphisms (SNPs) in inflammatory diseases and uses thereof, and methods of screening for, diagnosing, identifying susceptibility to or detecting a risk of developing an inflammatory disease comprising detecting the presence or absence of at least one SNP identified in a gene associated with inflammatory disease. | 2013-07-25 |
20130189693 | IDENTIFICATION OF ISOLATED GENOMIC NUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN SMS3 AND VARIANTS THEREOF - Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human SMS3 (SMS3) and methods of use. | 2013-07-25 |
20130189694 | IDENTIFICATION OF ISOLATED GENOMIC NUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 6 (TSSC6) AND VARIANTS THEREOF - Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human tumor suppressing subtransferable candidate 6 and methods of use. | 2013-07-25 |
20130189695 | IDENTIFICATION OF ISOLATED GENOMIC NUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN RIBOSOMAL PROTEIN L26 (RIBO26) AND VARIANTS THEREOF - Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human ribosomal protein L26 (RIBO26) and methods of use. | 2013-07-25 |
20130189696 | Screening Methods for Transfusion Related Acute Lung Injury (TRALI) - The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids in a sample of a biological tissue intended for transplantation | 2013-07-25 |
20130189697 | IDENTIFICATION OF ISOLATED GENOMIC NUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 (TSSC4) AND VARIANTS THEREOF - Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human and tumor suppressing subtransferable candidate 4 (TSSC4) and methods of use. | 2013-07-25 |
20130189698 | In Situ Cloning From Pathological Tissue Specimens - The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of oligonucleotide sequence probes comprising degenerate sequence tags to a fixed tissue, isolating the hybridized oligonucleotide sequence probes and amplifying the sequence tags in the hybridized oligonucleotide sequence probes. This method can be utilized to identify genes associated with disease and to quantitate the expression of disease-related transcripts. The method can also be used to identify truncated mRNAs. | 2013-07-25 |
20130189699 | IONIC SIGNAL ENHANCEMENT - Provided is a method of identifying an unknown nucleic acid comprising the steps of combining the unknown polynucleic acid with known nucleic acid reagents in a reaction chamber; producing a first quantity of protons from a polymerisation reaction when bases of one or more of the unknown nucleic acids are complementary to the bases of one or more known nucleic acids comprised within the known reagents; producing a second quantity of protons from a hydrolysis reaction of by-products of the polymerisation reaction with one or more enzymes; monitoring an electrical output signal derived from an ISFET exposed to the reaction chamber; and correlating changes in an output signal with said reactions between the unknown polynucleic acid and said known reagents to thereby identify the unknown nucleic acid. | 2013-07-25 |
20130189700 | BREAKAGE OF AN EMULSION CONTAINING NUCLEIC ACID - Methods of processing an emulsion of aqueous droplets containing nucleic acid. The methods may include breakage of the emulsion with a destabilizing fluid including a halogen-substituted hydrocarbon. | 2013-07-25 |
20130189701 | METHODS AND COMPOSITIONS FOR THE DETECTION AND IDENTIFICATION OF ARCHAEA BASED ON THE TYPE II CHAPERONIN (THERMOSOME) GENE - The present invention relates to primers for the universal amplification and detection of Archaea, which primers are designed based on a multiple sequence alignment of Archaea Type II chaperonin (thermo-some) genes. For detection of Archaea having templates with a GC content of below 60%, primers are designed so that inosine residues are found at degenerate positions. For amplification of higher GC content templates, degenerate positions are replaced with specific nucleotide bases found in the high GC organism. The primers are useful for detecting, identifying and quantifying Archaea in a sample and for determining a phylogenetic relationship of a test Archaea organism. | 2013-07-25 |
20130189702 | Curve Processor Algorithm for the Quality Control of (RT-) qPCR Curves - The invention is in the field of analytical technology and relates to an improved procedure for determining the concentration or activity of an analyte in a sample. Specifically the invention provides an automated algorithm for the quality control of (RT-)qPCR reactions. Plotting the fluorescence intensity of a reporter dye divided by the fluorescence intensity of a passive reference dye against the cycle number leads to a so-called sigmoid function which is characterized by a background phase, an exponential growth phase and a plateau phase. Since the fluorescence intensity as a function of cycles relates to the initial number of template molecules in the sample, qPCR curves can be used to quantify the amount of RNA or DNA fragments in the sample by determination of a so-called Cq value. | 2013-07-25 |
20130189703 | METHOD FOR IDENTIFYING HB RED-COROLLA UPLAND COTTON - A method for identifying HB red-corolla germplasm resources of upland cotton by PCR, including: amplifying genomic DNAs of the upland cotton by PCR using a pair of primers; performing gel electrophoresis on amplified products; and determining whether PCR products is derived from upland HB red-corolla cotton based on results of the gel electrophoresis. | 2013-07-25 |
20130189704 | NUCLEIC ACID DETECTION ASSAY - This invention is directed, inter alia, to methods and kits for rapid, easy and cost-effective methods of breast cancer prediction and diagnosis in inter alia, blood samples. | 2013-07-25 |
20130189705 | MONOCLONAL ANTIBODIES AGAINST PCBP-1 ANTIGENS, AND USES THEREFOR - The present invention provides and includes monoclonal antibodies (MoAbs or mAbs) specific or preferentially selective for PCBP-1 antigens, hybridoma lines that secrete these PCBP-1 antibodies or antibody fragments, and the use of such antibodies and antibody fragments to detect PCBP-1 antigens, particularly those expressed by cancer cells. The present invention also includes antibodies that are specific for or show preferential binding to a soluble form of PCBP-1. The present invention further includes chimeric and humanized antibodies, processes for producing monoclonal, chimeric, and humanized antibodies using recombinant DNA technology, and their therapeutic uses, particularly in the treatment or diagnosis of cancer progression. The present invention further includes methods and kits for the immunodetection and immunotherapy of cells for samples which express PCBP-1 antigens. | 2013-07-25 |
20130189706 | BIOSENSOR USING WHISPERING GALLERY MODES IN MICROSPHERES - A biosensor for detecting the presence of a target analyte is disclosed. The biosensor is formed from microspheroidal particles which have had a binding partner for the target analyte immobilized on their surfaces. The binding partners may be nucleotides; peptides, proteins, enzymes, antibodies and so on. When the analyte binds to its partner, the whispering gallery mode (WGM) profiles of the micro spheroidal particles change such that the profile peaks undergo a red- or blue-shift. The immobilized binding partners may include fluorophores and the like so that they emit fluorescence, phosphorescence, incandescence and the like. These fluorophores may take the form of a nanocrystal or quantum dot. | 2013-07-25 |
20130189707 | METHOD OF DETERMINATION OF AUTOANTIBODY LEVEL BY MEANS OF ENZYME IMMUNOASSAY - The method for quantitative determination of the level of natural autoantibodies in human biological fluids, when as a solid phase of physical sorption is used the solid phase of physical sorption, coated with streptavidin, and the solid phase of physical sorption is treated with preliminary biotinylated antigen and blocking agent for closing the sites of nonspecific binding at the solid phase of physical sorption, for which purpose are used proteins, biotinylated according to standard procedure. As the conjugate-containing solution are used enzyme-labeled monoclonal and polyclonal antibodies, which react with one or all isotypes of human immunoglobulins. In addition, the tested biological fluid is preliminary diluted in a buffer, containing proteins which are used for closing the sites of nonspecific binding at solid phase of physical sorption, and also substances protecting natural autoantibodies from destruction during heat treatment, and subjected to heat treatment. For each tested specimen of biological fluid, a control solid phase of physical sorption is used, and the number of natural autoantibodies is determined with the use of a calibration curve which is plotted using monoclonal or polyclonal antibodies to antigen. | 2013-07-25 |
20130189708 | SAMPLE ANALYZER AND A SAMPLE ANALYZING METHOD - Herewith disclosed is a sample analyzer comprising: a measurement section configured to perform a measurement on a sample and generate a measurement value according to the concentration of an analyte in the sample; a memory storing a calibration curve; an analysis section; an output section; and an instruction receiver. When the instruction receiver receives an instruction to perform a diluting measurement on a calibration sample, the measurement section dilutes the calibration sample by a predetermined ratio and performs a measurement on the diluted calibration sample, and the analysis section determines the concentration of the analyte in the diluted calibration sample by applying a measurement value obtained from the diluted calibration sample to the calibration curve. Information generated based on the determined concentration and the known concentration is output. | 2013-07-25 |
20130189709 | Multiplanar Lateral Flow Assay with Sample Compressor - A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone. | 2013-07-25 |
20130189710 | Method And Assay Kit For Detection Of Toxicity Induced By Pyrrolizidine Alkaloids - An antibody, which specifically recognizes adducts between pyrrole and cellular macromolecules. Such adducts are likely to occur in mammals suffering an incident of pyrrolizidine alkaloid poisoning. The antibody can be produced using a synthetic immunogen conjugated with a pyrrole as a hapten and it can be used, for example in an assay kit and/or by itself, as a novel means for detecting or diagnosing pyrrolizidine alkaloid poisoning both clinics and research laboratories. | 2013-07-25 |
20130189711 | METHODS, PRODUCTS AND TREATMENTS FOR DIABETES - The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided. | 2013-07-25 |
20130189712 | T2R, A NOVEL FAMILY OF TASTE RECEPTORS - The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors. | 2013-07-25 |
20130189713 | PLATELET AGGREGATION ASSAYS - The present invention provides methods of determining platelet aggregation, methods of determining susceptibility to clotting upon administration of a CD40L-binding moiety, and kits related thereto. | 2013-07-25 |
20130189714 | METHOD FOR THE DETECTION AND/OR QUANTIFICATION OF THE INTERACTION OF PLATELETS WITH INTERACTION PARTNERS - The invention refers to methods for detecting and/or quantifying the interaction of platelets or platelet surface molecules with an interaction partner, methods for detecting and/or quantifying the capability of a test substance to modulate the interaction of platelets or platelet surface molecules with interaction partners and articles or manufacture. | 2013-07-25 |
20130189715 | Hemolysin and its Protein Fragments in Sero-Detection of Anaplasma Phagocytophilum - Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in | 2013-07-25 |
20130189716 | METHOD FOR IDENTIFYING A SUBJECT AT RISK OF DEVELOPING HEART FAILURE BY DETERMINING THE LEVEL OF GALECTIN-3 OR THROMBOSPONDIN-2 - The present invention relates to a method for identifying a subject at risk of developing hypertensive and organ damage, such as and in particular heart failure, comprising: a) obtaining a biological sample of said subject; b) determining the level of at least one non-myocytal marker in said sample; c) comparing the level of said marker to a standard level; and d) determining whether the level of the marker is indicative of a risk for developing hypertensive end organ damage. The non-myocytical marker preferably is galectin-3 or thrombospondin-2. | 2013-07-25 |
20130189717 | ASSAY METHOD FOR THE DETECTION OF VIABLE MICROBIAL CELLS IN A SAMPLE - The present invention discloses an assay method for the detection of viable microbial cells in a sample, the assay method comprising the steps of: i) adding an ATP degrading enzyme to a sample suspected of containing viable microbial cells to substantially degrade any extracellular ATP in the sample; ii) adding a phosphate containing compound to the sample to substantially halt action of the ATP degrading enzyme; and iii) subjecting the sample to a detection assay to establish the level of undegraded ATP in the sample to provide an indication of the level of viable microbial cells in the sample. | 2013-07-25 |
20130189718 | ASSAYS FOR DETECTION OF GLYCOSAMINOGLYCANS - Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS), The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples. | 2013-07-25 |
20130189719 | ENZYME DETECTION - An enzyme detection product ( | 2013-07-25 |
20130189720 | HIGH ENERGY RADIATION INSENSITIVE ANALYTE SENSORS - Enzyme based analyte sensors having radiation stabilizing agents are disclosed and described. More particularly, devices comprising a radiation stabilizing agent and methods for stabilizing sensors to high energy radiation sterilization are disclosed and described. | 2013-07-25 |
20130189721 | Method for Producing Dry Reagent, Dry Reagent, and Analysis Tool Using Same - Provided is a dry reagent that allows measuring with good precision, in accordance with a transmission method that utilizes light of the ultraviolet region, increases or decreases of a nicotinamide coenzyme, in order to quantify a component contained in a liquid sample. | 2013-07-25 |
20130189722 | ISOLATION OF PELLET-FORMING MICROORGANISMS - The present disclosure provides technologies for identifying, characterizing and/or sorting pellet-forming microorganisms such as bacteria and/or fungi (e.g., yeast) in liquid culture, and particularly under fermentation conditions. In some embodiments, the pellet-forming microorganisms produce one or more commercial products. For example, in some embodiments the pellet-forming microorganisms produce one or more organic acids, carotenoid compounds, essential fatty acids, industrial enzymes, active pharmaceuticals, extracellular carbohydrates, and insecticidal compounds, etc. In many embodiments, the organisms are sorted while in their pellet form. | 2013-07-25 |
20130189723 | AUTOMATED CELL CULTURE SYSTEM AND PROCESS - The present invention relates generally to the field of cell culture, which is a laboratory process used primarily for the growth, propagation, and production of cells for analysis and the production and harvesting of cell products. The present invention comprises functionalized and/or engineered hydrogel microcarriers that exhibit any or all of the following properties: controllable buoyancy, ferro- or paramagnetism, molecular or fabricated reporting elements, and optical clarity. The microcarriers are used in a bioreactor that employs external forces to control said microcarrier kinetic energy and translational or positional orientation in order to facilitate cell growth and/or cellular analysis. The bioreactor can be part of an automated system that employs any or all of the following; a microcarrier manufacturing method, a monitoring method, a cell culture method, and an analytical method. Either a single bioreactor or a plurality of bioreactors are used in the automated system to enable cell culture and analysis with a minimum of human intervention. | 2013-07-25 |
20130189724 | USE OF AN ADAPTIVE CHEMICALLY REACTIVE PLASMA FOR PRODUCTION OF MICROBIAL DERIVED MATERIALS - A carbonaceous feedstock can be converted into a chemical product having a higher commercial value, by introducing the carbonaceous feedstock into a plasma torch under conditions selected to generate a synthetic gas mixture having a tailored composition, and then introducing the synthetic gas mixture into a microbial digester configured to convert the synthetic gas mixture into the chemical product. The composition of the synthetic gas mixture produced by the plasma torch can be quickly modified to yield an optimal quality and quantity required by the microbial digester, and the quantity and stoichiometric ratio can be quickly varied if the quantity or composition of the synthetic gas mixture being provided is not appropriate for the microbial digester, enabling greater efficiency to be achieved as compared to systems where the quality and quantity of the synthetic gas mixture cannot be easily changed. | 2013-07-25 |
20130189725 | HUMAN IN VITRO MODEL OF THE BLOOD CEREBROSPINAL FLUID BARRIER - The present invention relates to a human in vitro model system of the blood cerebrospinal fluid barrier (BCSFB), to a method for producing said model system, as well as to uses thereof. | 2013-07-25 |
20130189726 | METHOD FOR PREPARING AND/OR PROCESSING A BIOLOGICAL SAMPLE USING A MALODOUR COUNTERACTANT - The present invention pertains to a biotechnological method for preparing and/or processing a biological sample, in particular for isolating at least one target biomolecule therefrom, which characterised in that at least one malodour counteractant is used for preventing, reducing, masking and/or suppressing malodour and/or malodour formation during the preparation and/or processing of said biological sample. | 2013-07-25 |
20130189727 | Methods And Compositions For Cellular Imaging And Cancer Cell Detection Using Light Harvesting Conjugated Polymer-Biomolecular Conjugates - The invention is a compound represented by any one of Structural Formulas (I)-(IV), or a salt thereof, wherein the values and alternative values for the variables are as defined in the Detailed Description of the Invention. Methods using a compound of Structural Formula (I)-(IV), or a salt thereof, are also presented. | 2013-07-25 |
20130189728 | Identification of pathogens in body fluids - Identification of infectious pathogens, particularly viruses, bacteria and other microorganisms is effected with a method whereby pathogens of acute infections can be identified, without first culturing them in external nutrient media, by mass spectrometric measurement of their protein profiles obtained from pathogens directly precipitated from body fluid into pellets by centrifuging. With this method, pathogens which cause acute infections can be identified in less than one hour. | 2013-07-25 |
20130189729 | FIXATIVE AND STAINING SOLUTIONS - The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens. | 2013-07-25 |
20130189730 | DEWAXING BUFFER CONTAINING A WATER-SOLUBLE ORGANIC SOLVENT AND METHODS OF USE THEREOF - Dewaxing buffers containing a water-soluble organic solvent, methods for use thereof, and kits incorporating dewaxing buffers. The dewaxing buffers contain a water soluble organic solvent that has a boiling point of at least 80° C. The dewaxing buffers described herein can be used to quickly and efficiently remove embedding paraffin from slide-mounted tissue sections in an aqueous buffer solution at elevated temperature without fear of paraffin redeposition of the slides. In addition, the dewaxing buffers described herein can be used to perform dewaxing and HIER in a single step, which can substantially reduce protocol time and lower the risk of sample loss or damage. | 2013-07-25 |
20130189731 | MODIFIED TRANSKETOLASE AND USE THEREOF - The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B | 2013-07-25 |
20130189732 | Protease Variants - The invention relates to a novel 3D structure encoding a | 2013-07-25 |
20130189733 | PRODUCTION OF SECRETED PROTEINS BY FILAMENTOUS FUNGI - The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype. | 2013-07-25 |
20130189734 | Polypeptides Having Cellobiohydrolase Activitiy and Polynucleotides Encoding Same - The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2013-07-25 |
20130189735 | Process for engineering polyvalent, polyspecific fusion proteins using uteroglobin as skeleton and so obtained products. - It is described a processes for generating stable and soluble polyvalent and polyspecific fusion proteins based on the use of uteroglobin (UG) as a reaction skeleton; proteins as above defined produced with said process are also described. | 2013-07-25 |
20130189736 | ANTIBODY COMPOSITION-PRODUCING CELL - The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof. | 2013-07-25 |
20130189737 | DIPEPTIDES TO ENHANCE YIELD AND VIABILITY FROM CELL CULTURES - The present invention relates to the culture of animal cells in serum-free culture medium. The present invention provides particular dipeptides that can improve recombinant protein production and cell viability in such cultures, especially in the absence of peptones. | 2013-07-25 |
20130189738 | FIBROUS MATERIALS AND COMPOSITES - Fibrous materials, compositions that include fibrous materials, and uses of the fibrous materials and compositions are disclosed. For example, the fibrous materials can be operated on by a microorganism to produce ethanol or a by-product, such as a protein or lignin. | 2013-07-25 |