30th week of 2014 patent applcation highlights part 42 |
Patent application number | Title | Published |
20140205981 | DIALYSIS TREATMENT SIMULATION SYSTEMS AND METHODS - A dialysis treatment simulation system and method are provided that comprise a treatment simulator, a computing module, and a user interface. The treatment simulator generates an event notification that simulates a notification of an event related to an interaction between a dialysis treatment machine and a patient. The computing module generates a request for a user action in response to the simulated event notification. The user interface outputs the simulated event notification and the request for the user action to an output device and provides a received user response to the computing module. | 2014-07-24 |
20140205983 | Interactive Education System for Teaching Patient Care - An interactive education system for teaching patient care to a user is described. The system comprises a patient simulator; a virtual instrument for use with the patient simulator in performing patient care activities; means for sensing an interaction between the virtual instrument and the simulator, and means for providing feedback to the user regarding the interaction between the virtual instrument and the simulator. In one aspect, the system includes a maternal simulator, a fetal simulator, and a neonatal simulator. | 2014-07-24 |
20140205984 | SYSTEMS AND METHODS FOR MONITORING LEARNER ENGAGEMENT DURING A LEARNING EVENT - According to some aspects there is provided a learning system including at least one capture device for monitoring activity of at least one learner and at least one processor configured to: monitor the activity of the at least one learner during a learning event using the at least one capture device to generate learner activity data associated with the at least one learner; generate learner engagement data based upon the learner activity data associated with of the at least one learner, the learner engagement data being indicative of how engaged the learner is during the learning event; generate at least one learner engagement report based upon the learner engagement data; and provide the at least one learner engagement report to a computing device associated with an instructor. | 2014-07-24 |
20140205985 | Method and Apparatus for Responding to an Inquiry - Disclosed is a method and apparatus for responding to an inquiry from a client via a network. The method and apparatus receive the inquiry from a client via a network. Based on the inquiry, question-answer pairs retrieved from the network are analyzed to determine a response to the inquiry. The QA pairs are not predefined. As a result, the QA pairs have to be analyzed in order to determine whether they are responsive to a particular inquiry. Questions of the QA pairs may be repetitive and, without more, will not be useful in determining whether their corresponding answer responds to an inquiry. | 2014-07-24 |
20140205986 | BRAIN BASED LEARNING METHOD - A brain research-based learning method is provided. The learning method begins by a user viewing a presentation that provides a quantity of information to the user. During the viewing, the user may answer a plurality of periodic prompts on a computer relating to the presentation. After the presentation, the user may answer a series of questions on a computer. Later, at periodic intervals after the presentation the user is provided a second series of questions to reinforce the learned information. In the event of an incorrectly answered question, the computer may provide an alert. Further, after the presentation, a long term memory storage activity may be performed by the user using a computer. Finally the learning progress of the user may be provided using the at least one computer. | 2014-07-24 |
20140205987 | APPARATUS AND METHOD FOR ENHANCING ACADEMIC PLANNING AND TRACKING VIA AN INTERACTIVE REPOSITORY DATABASE - An apparatus and method to collect, integrate, and marshal the academic course offerings and requirements of secondary educational institutions, the admission requirements and preferences of postsecondary educational institutions, and the academic and career goals of current and prospective secondary students to assist and facilitate the creation of academic plans in a collaborative informed manner. The apparatus collects relevant information from various informed parties and makes such information available in an integrated and marshaled form enabling efficient and effective planning. The system can be adapted to assist in the academic planning of postsecondary students in light of the admissions requirements and preferences of graduate and postgraduate programs as well. | 2014-07-24 |
20140205988 | SYSTEM, SOFTWARE AND ASSOCIATED METHOD OF USE THEREOF FOR THE TRANSFER OF INFORMATION BETWEEN A MODERATOR ADN RECIPIENTS - The present invention relates to a web-based computer system, a web-based computer software, and a method of use thereof for the transfer of information between a moderator and a plurality of recipients either in a face-to-face environment or in a remote environment, and more specifically the use of a moderator station, a projector display, and a plurality of user web-enabled devices connected to a network in a group and team competitive environment. | 2014-07-24 |
20140205989 | SYSTEM AND METHOD FOR DETECTING A POINT OF ORIGINALITY IN A WRITING - This paper proposes a new method for the objective evaluation of student work through the identification of original content in writing assignments. Using WordNet as a lexical reference, this process allows instructors to track how key phrases are employed and evolve over the course of a student's writing, and to automatically visualize the point at which the student's language first demonstrates original thought, phrased in their own, original words. After sketching the method for isolating “points of originality,” the paper provides a method for visualizing the resulting information. By visualizing otherwise subjective information in a way that is objectively intelligible, the goal is to provide educators with the ability to monitor student investment in concepts from the course syllabus, and to extend or modify the boundaries of the syllabus in anticipation of pre-existing knowledge or trends in interest. | 2014-07-24 |
20140205990 | Machine Learning for Student Engagement - Apparatuses, systems, methods, and computer program products are disclosed for determining student engagement. A method includes receiving data collected from interactions of a plurality of students with an electronic learning system. A method includes identifying a plurality of archetypal learning patterns in received data using machine learning. A method may also include associating a student with at least one identified archetypal learning patterns using machine learning. | 2014-07-24 |
20140205991 | SYSTEM AND METHOD FOR PROVIDING TEACHING-LEARNING MATERIALS CORRESPONDING TO REAL-WORLD SCENARIOS - A method is provided for providing teaching-learning materials corresponding to real-world scenarios. Teaching-learning materials are provided and stored in advance, wherein each item of the teaching-learning materials corresponds to coordinates marking locations for at least one landmark. A service request specifying the coordinates of a location for a specific client device is received. One item of the teaching-learning materials is then selected in response to the service request, wherein the selected teaching-learning material corresponding to the landmark that is located on or near the location of the client device. Learning service is provided based on the selected teaching-learning material. | 2014-07-24 |
20140205992 | System and Method for Demonstrating a Path of a Projectile - A system for demonstrating a path of a projectile comprises a flexible wire, a first attachment device connected to a first end of the flexible wire, a second attachment device connected to a second end of the flexible wire, a coupling assembly comprising a trajectory rod attachment device configured to attach to a trajectory rod and a wire attachment device movably connected to the trajectory rod attachment device and configured to attach to the flexible wire. | 2014-07-24 |
20140205993 | RECOMBINANT AVIAN INFLUENZA VACCINE AND USES THEREOF - The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines. | 2014-07-24 |
20140205994 | Methods, Devices, Kits and Compositions for Detecting Roundworm, Whipworm, and Hookworm - Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated. | 2014-07-24 |
20140205995 | MOLECULAR CONJUGATE - A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an Fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays. | 2014-07-24 |
20140205996 | DISSOLVABLE FILMS AND METHODS INCLUDING THE SAME - A method includes providing a container, introducing a substance into the container, and introducing a readily dissolvable film into the container such that the dissolvable film overlies the substance within the container. An alternative method includes providing a container, providing a readily dissolvable film, the film comprising a substance carried by the film, and introducing the film into the container. | 2014-07-24 |
20140205997 | FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS - Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. | 2014-07-24 |
20140205998 | METHOD FOR ENHANCING EXTRACTION EFFICIENCY OF MIRNA FROM CELLS BY THE ADDITION OF TRITON X-100 - The present invention relates to a method for improving detection efficiency of miRNAs existing in cells in trace amounts by adding Triton X-100. In accordance with the present invention, miRNAs existing in a sample in trace amounts can be quantitatively analyzed in short time. Further, the miRNA detection method according to the present invention wherein Triton X-100 is used can improve detection efficiency by about 2 times as compared to when only a TRIzol reagent is used. | 2014-07-24 |
20140205999 | COMPOSITIONS FOR DETECTING SMALL RNAS - Compositions and reaction mixtures are provided for the detection of small RNA target nucleic acids, preferably miRNA target nucleic acids, wherein the compositions and reaction mixtures provide for sensitive and specific detection of the target nucleic acids. The compositions and reaction mixtures include one or more of a first amplification oligomer that is preferably an extender primer, a target capture oligomer that is preferably at least partially double stranded, a promoter primer/provider, a reverse primer that is preferably a universal primer and a detection probe. The compositions and reaction mixtures are useful for diagnostics, prognostics, monitoring the effectiveness of treatment and/or determining a treatment. | 2014-07-24 |
20140206000 | SEQUENCE AMPLIFICATION WITH LINEAR PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. The use of these primers, as described herein, allows for the reduction in the amplification of nonspecific hybridization events (such as primer dimerization) while allowing for the amplification of the target nucleic acid sequences. | 2014-07-24 |
20140206001 | METHODS AND COMPOSITIONS FOR ENRICHMENT OF NUCLEIC ACIDS IN MIXTURES OF HIGHLY HOMOLOGOUS SEQUENCES - Provided are methods of enrichment and detection of target nucleic acids during target amplification in the presence of excess amounts of highly homologous sequences, said methods having substantial diagnostic utility (e.g., cancer diagnostics). Provided are amplification reaction mixtures having at least one cleavage-directing oligonucleotide, the respective binding sites of which, for the target and homologous sequences, include one or more nucleotide positions differing in sequence between the target homologous sequences. During target sequence amplification in the presence of DNA polymerase activity, a FEN1 activity, one or more amplification primers, deoxynucleoside 5′-triphosphates and other reagents suitable to support amplification of both target and homologous nucleic acid sequences, the cleavage-directing oligonucleotide hybridizes to the homologous sequence and its amplification products resulting in a FEN1-mediated cleavage of these sequences providing for increased amounts of the target nucleic acid sequence relative to that of the homologous nucleic acid sequences. | 2014-07-24 |
20140206002 | Methods of Diagnosing Breast Cancer - The disclosed subject matter is based on the discovery that a mutation (a single nucleotide polymorphism or “SNP”) in the gene encoding Abraxas (also referred to as ABRA1, CCDC98 or FAM175A), is associated with susceptibility to cancer, e.g., breast cancer. In particular, the disclosed subject matter is based on the identification of a heterozygous alteration in the Abraxas gene that is associated with breast cancer and specifically correlated with familial cancer. Accordingly, the SNP disclosed herein is useful for diagnosing, prognosing, screening for, and evaluating predisposition to cancer in humans. The disclosed subject matter also provides nucleic acid molecules containing the SNP, methods and reagents for the detection of the SNP, and assays or kits for detection of the SNP. | 2014-07-24 |
20140206003 | Genetic Lesion Associated with Cancer - The invention comprises methods for identifying mutations within the 3′UTR of genes that lead to increased risk or probability of developing cancer. | 2014-07-24 |
20140206004 | RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING HUMAN AND NON-HUMAN PRIMATE TASTE SPECIFIC GENES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING ASSAYS - This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures. | 2014-07-24 |
20140206005 | Method and Kit for DNA Typing of HLA Gene - The purpose of the present invention is to provide a method and kit for highly precise DNA typing, in which ambiguity derived from phase ambiguity is eliminated. The present invention provides a method for the DNA typing of HLA, which is characterized by comprising: (1) a step of preparing a set of primers which can respectively anneal specifically to an upstream region and a downstream region of each of HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1, HLA-DPA1 and HLA-DPB1 gene in the nucleotide sequence for the human genome, and a set of primers which can respectively anneal specifically to exon-2 and a 3′-side non-translated region in HLA-DRB1; (2) a step of carrying out the PCR amplification of a sample to be tested (DNA) using the sets of primers; (3) a step of determining the nucleotide sequence for a PCR-amplified product; and (4) an optional step of carrying out the homology search in a data base. | 2014-07-24 |
20140206006 | SINGLE CELL CLASSIFICATION METHOD, GENE SCREENING METHOD AND DEVICE THEREOF - Provided are a single cell classification method, a gene screening method and a device for implementing the method. In that, the single cell classification method includes the following steps: sequencing the whole genomes of a plurality of single cell samples from the same group, respectively, so as to obtain reads from each single cell sample; aligning the reads from each single cell sample to the sequence of a reference genome, respectively, and performing data filtering on said reads; on the basis of the filtered reads, determining a consistent genotype of each single cell sample, in which consistent genotypes of all the single cell samples constitute an SNP dataset of said group; aimed at said each single cell, on the basis of the SNP dataset of said group, determining a corresponding genotype for each cell at a site corresponding to a position in an SNP dataset of the reference genome; and selecting an SNP site associated with cell mutation, and on the basis of the genotype of said single cell at the site, classifying said single cell. | 2014-07-24 |
20140206007 | ELECTROMAGNETICALLY ACTUATED DROPLET MICROFLUIDIC CHIP AND SYSTEM - A microfluidic system includes a microfluidic cartridge and an electromagnetic droplet actuator arranged proximate the microfluidic cartridge. The microfluidic cartridge includes a plurality of droplet wells with topological barrier structures between adjacent wells. The topological barrier structures are configured to allow magnetic particles and material attached to the magnetic particles to pass between adjacent wells while confining droplets within respective wells. The electromagnetic droplet actuator includes a plurality of electromagnetic components arranged to provide an electronically selectable magnetic field pattern to actuate movement of a plurality of magnetic particles when contained within at least one droplet in at least one of the plurality of droplet wells. | 2014-07-24 |
20140206008 | Salivary Protein Biomarkers for Human Oral Cancer - The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a prognosis for oral cancer and periodontal disease. The present invention additionally provides novel methods of distinguishing between oral cancer and periodontal disease. Finally, kits are provided that find use in the practice of the methods of the invention. | 2014-07-24 |
20140206009 | MICROFLUIDIC DEVICE-BASED NUCLEIC ACID PURIFICATION METHOD - A method is provided for purifying nucleic acid from a sample in a microfluidic device. The method can be used to purify nucleic acids from any source known in the art that comprises nucleic acids, such as prokaryotic or eukaryotic organisms, viruses, cell, tissues, organs, etc. In a specific example, the tissue is whole blood. The method for purifying nucleic acid may run fully automated in the microfluidic device. | 2014-07-24 |
20140206010 | METHODS AND KITS FOR DETECTING MASTITIS - Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein. Components and reagents for use in the kits and assays are also disclosed. | 2014-07-24 |
20140206011 | METHODS AND COMPOSITIONS OF DIAGNOSING AND TREATING FUSOBACTERIUM NUCLEATUM RELATED DISORDERS - A method of identifying a subject with increased risk of colorectal cancer includes obtaining a biological sample from the subject, measuring the level of | 2014-07-24 |
20140206012 | Method for Identifying Agents that Inhibit Cell Migration, Promote Cell Adhesion and Prevent Metastasis - Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. The methods have utility in tissue engineering as well as identifying agents that prevent cancer cell metastasis, wound dehiscence, aortic dissection and aid retina attachment and skin replacement and fertility. Examples of tissue engineering include techniques that allow for the generation of biological substitutes that restore, maintain, or improve tissue function or a whole organ. | 2014-07-24 |
20140206013 | SPLIT PEROXIDASES AND METHODS OF USE - An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to allow conversion of a substrate into a product via an enzymatic reaction catalyzed by the reconstitute split peroxidase. Also disclosed herein are split peroxidases, related products and kits. | 2014-07-24 |
20140206014 | METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE VARIANTS - The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method. | 2014-07-24 |
20140206015 | METHOD FOR DETECTING NUCLEOSOMES - The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and the use of such measurements for the detection and diagnosis of disease. | 2014-07-24 |
20140206016 | Rapid Method for Detection of Pathogen - The present specification discloses methods of detecting a pathogen of interest and components useful in carrying out these methods, including a pre-enrichment media, and enrichment media and a detection solution. | 2014-07-24 |
20140206017 | LYSYL OXIDASE-LIKE 2 ASSAY AND METHODS OF USE THEREOF - The present disclosure provides an assay to detect and/or quantify circulating lysyl oxidase-like 2 (LOXL2) poly-peptides in an individual. The assay is useful in diagnostic and prognostic applications, which are also provided. | 2014-07-24 |
20140206018 | ANTIBODIES AGAINST FATTY ACID SYNTHASE - The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders. The invention also relates to FAS-derived peptides useful for preparing the antibodies. Methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other proliferative disorders using the present antibodies also are disclosed. | 2014-07-24 |
20140206019 | FC-FUNCTION ASSAY - The present invention discloses a method of assaying Fc-function in an immunoglobulin containing sample by contacting the sample, in the presence of a complement, with red blood cells modified to incorporate a F-S-L peptide-lipid construct. The F-S-L peptide construct comprises a functional group (F) that is a target antigen for a complement activating immunoglobulin, a spacer group (S) covalently linking F to L and a lipid group (L). The present invention further discloses a specific construct, DOPE-Ad-CMG(2)-hCMV2 where the F group is an antigen of cytomegalovirus, that is used in assaying the Fc function of an intravenous immunoglobulin (IVIG) product. | 2014-07-24 |
20140206020 | Voriconazole Immunoassays - Methods, compositions and kits are disclosed directed at voriconazole derivatives, immunogens, signal generating moieties, antibodies that bind voriconazole and immunoassays for detection of voriconazole. | 2014-07-24 |
20140206021 | PRION PROTEIN LIGANDS AND METHODS OF USE - Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject | 2014-07-24 |
20140206022 | THREE-DIMENSIONAL CELL CULTURE METHODS FOR TEST MATERIAL ASSESSMENT OF CELL DIFFERENTIATION - The present specification discloses three-dimensional in vitro cell-based methods to assess a test matrix polymer ability to support differentiation of a population of cells methods of screening a material for its ability to stimulate cell growth and/or differentiation. | 2014-07-24 |
20140206023 | Methods, Kits & Antibodies for Detecting Intact Fibroblast Growth Factor 21 - Disclosed are methods, compositions and kits related to immunoassays for detection of FGF21 using antibodies specific to the N-terminal and/or C-terminal of FGF21. The present invention provides antibodies specific to N-terminal or C-terminal peptide of FGF21. Also provided are immunoassays for specifically measuring intact FGF21 or FGF21 with an untruncated N- or C-terminal region. | 2014-07-24 |
20140206024 | STABLE NAD/NADH DERIVATIVES - The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits. | 2014-07-24 |
20140206025 | Use Of Detection Of Aspartate Transaminase And Lactate Dehydrogenase In Early Evaluation Of Clinical Efficacy Of Antitumor Intervention Measure - The present invention relates to a method for early evaluation of clinical efficacy of antitumor intervention measure, comprising evaluating the efficacy of the antitumor intervention measure by assaying whether the content of a tumor-damaging biomarker(s) in the blood of a patient having tumor rises as compared to the baseline level before treatment within a time window after the patients receives at least one antitumor intervention measure. In preferable embodiments, the tumor-damaging biomarker(s) is selected from a group consisting of Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Lactate Dehydrogenase (LDH); said tumor is multiple myeloma; said antitumor intervention measure is the administration of CPT alone or the administration of CPT in combination with thalidomide. | 2014-07-24 |
20140206026 | Method for Screening Alpha-Amylases - The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2014-07-24 |
20140206027 | METHOD FOR QUANTIFICATION OF ALLERGENS - The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising:
| 2014-07-24 |
20140206028 | Stable Electrically Active Neurons from Adult Tissue - Disclosed are compositions and methods of making stable electrically active adult neurons from adult neural tissue. The disclosed compositions can be used with microelectrode arrays in vitro to represent in vivo neural function for drug discovery and for studying neuronal degenerative diseases, neuronal development, and neuronal regeneration. | 2014-07-24 |
20140206029 | IN VITRO CARDIOVASCULAR MODEL - The present invention relates to a tubule forming platform and an in vitro cardiovascular model for use in pharmacological studies. Furthermore, the invention relates to methods for the preparation said platform and model, and to a method of determining a biological activity of a test substance in said platform and cardiovascular model. Still further, the invention relates to an implantable cardiac structure for use in the treatment of cardiac disorders. | 2014-07-24 |
20140206030 | Dual Barcode Labeling Facilitating Automated Decapping - A specimen collection assembly and method for detecting the same are disclosed. The specimen collection assembly includes a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior adapted to receive a biological specimen. The specimen collection container also includes first indicia containing information. The assembly further includes a cap having thereon second indicia, the cap being removably engagable with the open top end of the container. The second indicia contains the same information as the first indicia. | 2014-07-24 |
20140206031 | Systems And Methods For High-Resolution Imaging - In one aspect, methods of imaging are described herein. In some embodiments, a method of imaging described herein comprises disposing a population of ultrasound-switchable fluorophores in a biological environment, the fluorophores having a switching threshold between an off state and an on state; exposing the biological environment to an ultrasound beam to create an activation region within the biological environment; switching at least one of the fluorophores within the activation region from the off state to the on state; exciting the at least one fluorophore with a beam of electromagnetic radiation; and detecting light emitted by the fluorophore. In some embodiments, the activation region has a maximum negative pressure and/or maximum temperature and the switching threshold of the at least one fluorophore is at least about 50 percent of the maximum negative pressure or at least about 50 percent of the maximum temperature of the activation region. | 2014-07-24 |
20140206032 | METHOD TO IDENTIFY DISEASE RESISTANT QUANTITATIVE TRAIT LOCI IN SOYBEAN AND COMPOSITIONS THEREOF - The present invention is in the field of plant breeding and genetics, particularly as it pertains to the genus, | 2014-07-24 |
20140206033 | METHODS AND APPARATUS FOR ANALYSIS OF AQUATIC CHEMICAL AND/OR BIOLOGICAL SYSTEMS - A preferred test system includes a chemical and/or biological sample in a liquid test medium and contains both a liquid and a gas phase that simulates air-water gas exchanges. It operates intermittently, with additions and eliminations of liquids being decoupled in time so that to make sure the medium is well mixed before eliminating any liquid; requirement for expensive fixed flow pumps, or accurate flow meters are eliminated while accurate measurement of fluxes between the chemical and/or biological sample, the liquid and the gas phase are possible by mass balance between added and eliminated liquids. | 2014-07-24 |
20140206034 | ELECTROKINETIC DEVICE FOR CAPTURING ASSAYABLE AGENTS IN A DIELECTRIC FLUID - Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. The agents are directed by creation of an electrokinetic potential well, which will affect their capture on to an assay device. The dielectric fluid medium, such as air, is sampled by electrokinetic propulsion with no moving parts or optionally, by transporting the dielectric fluid by a fan, pump or by breath. | 2014-07-24 |
20140206035 | POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains. | 2014-07-24 |
20140206036 | USE OF PROLINE SPECIFIC ENDOPROTEASES TO HYDROLYSE PEPTIDES AND PROTEINS - The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide. | 2014-07-24 |
20140206037 | DNA VECTOR PRODUCTION SYSTEM - A vector production system is provided. The system comprises recombinant cells designed to encode at least a first recombinase under the control of an inducible promoter and the cells include an expression vector encoding a nucleic acid of interest within the regulatory elements of the expression vector which are flanked on either side by a target sequence for at least the first recombinase. The vector production system provides an efficient one-step process for producing linear or circular covalently closed vectors that incorporate a nucleic acid sequence of interest. | 2014-07-24 |
20140206038 | CELL CULTURE IMPROVEMENTS - The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture. | 2014-07-24 |
20140206039 | METHODS OF SYNTHESIZING HETEROMULTIMERIC POLYPEPTIDES IN YEAST USING A HAPLOID MATING STRATEGY - Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein. | 2014-07-24 |
20140206040 | STREPTOCOCCUS DYSGALACTIAE ID9103 AND METHOD FOR PRODUCTION OF HYALURONIC ACID USING THE SAME - Provided is a | 2014-07-24 |
20140206041 | POLYCARBONATE MICROFLUIDIC ARTICLES - Microfluidic devices, and methods for their use are described. The microfluidic devices include articles formed from a thermoplastic composition comprising a poly(aliphatic ester)-polycarbonate comprising soft block ester units, derived from monomers comprising an alpha, omega C | 2014-07-24 |
20140206042 | METHOD OF ENZYMATICALLY SYNTHESIZING 3' -PHOSPHOADENOSINE-5'-PHOSPHOSULFATE - The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (ATPS) and adenosine 5′-phosphosulfate kinase (APSK), wherein an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and polyphosphate:AMP phosphotransferase (PAP), or an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and adenylate kinase (ADK) is employed instead of ATP. | 2014-07-24 |
20140206043 | DISPERSING FEEDSTOCKS AND PROCESSING MATERIALS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is dispersed in a liquid medium and then saccharified. | 2014-07-24 |
20140206044 | PROCESSING MATERIALS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is saccharified in a vessel by operation of a jet mixer, the vessel also containing a liquid medium and a saccharifying agent. | 2014-07-24 |
20140206045 | Thermostable Alpha-Amylases - The present invention relates to an isolated polynucleotide comprising an open reading frame encoding a polypeptide having alpha-amylase activity, the polypeptide selected from the group consisting of:
| 2014-07-24 |
20140206046 | Methods of Hydrolyzing and Fermenting Cellulosic Material - Described herein are improved methods of degrading or converting cellulosic material into fermentable sugars using dithionite. Also described are improved methods of fermentation in the presence of dithionite. | 2014-07-24 |
20140206047 | COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF - The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention. | 2014-07-24 |
20140206048 | COMPOSITIONS AND METHODS FOR BIOFERMENTATION OF OIL-CONTAINING FEEDSTOCKS - The present invention provides compositions and methods for the use of oil-containing materials as feedstocks for the production the bioproducts by biofermentation. In one preferred embodiment, surfactants are not used in compositions and the methods of the invention. In one preferred embodiment the oil-containing feedstocks are the by-products of other industrial processes including microbial, plant and animal oil processing. | 2014-07-24 |
20140206049 | METHOD FOR PRODUCING POLYHYDROXYALKANOIC ACID - Embodiments of the invention relate to the microbial production of polyhydroxyalkanoic acids, or polyhydroxyalkanoates (PHA), from substrates which cannot be used as a source of carbon and/or energy for microbial growth or PHA synthesis and which have microbial and environmental toxicity. According to one embodiment of the invention, a process for the production of PHA is provided wherein an enzyme such as methane monooxygenase is used to convert volatile organic compounds into PHA through the use of microorganisms that are unable to use volatile organic compounds as a source of carbon for growth or PHA production. | 2014-07-24 |
20140206050 | 2-Deoxy-Scyllo-Inosose Synthase - An object of the present invention is to provide a DOI synthase having properties such as stability to heat and pH, which are superior to those of conventional enzymes, and a method for producing DOI using the above-mentioned enzyme. The present invention provides a 2-deoxy-scyllo-inosose synthase having the properties described in the following (1), (2), (4), (6) and (7), and also having the properties described in the following (3) and/or (5): | 2014-07-24 |
20140206051 | Production of Stilbenoids - A method for the production of a stilbenoid, such as resveratrol or pinosylvin, by fermenting plant material such a grape must using a yeast having a metabolic pathway producing said stilbenoid, separating a solids waste material from said fermentation and extracting said stilbenoid. | 2014-07-24 |
20140206052 | Method for production of n-butanol from syngas using syntrophic co-cultures of anaerobic microorganisms - This invention provides methods and systems for the production of butanol. Specifically, the methods and systems of the present invention use syntrophic co-cultures for the production of butanol from syngas. | 2014-07-24 |
20140206053 | NOVEL KLUYVEROMYCES MARXIANUS STRAINS AND METHOD OF USING STRAINS - Described are novel | 2014-07-24 |
20140206054 | Genes Encoding Key Catalyzing Mechanisms for Ethanol Production From Syngas Fermentation - Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production. | 2014-07-24 |
20140206055 | METHOD FOR VISCOSITY REDUCTION IN CO-FERMENTATION ETHANOL PROCESSES - The present disclosure provides methods and compositions for reducing the viscosity of biomass process streams in an ethanol production process. The method comprises adding cellulase enzymes to a biomass feedstock that is fermented to produce ethanol, generating whole stillage and thin stillage streams from the post-fermentation biomass, and adding an additional enzyme or enzyme cocktail that reduces the viscosity of the whole stillage stream, thin stillage stream, concentrated thin stillage stream, and/or the syrup stream generated by evaporating the thin stillage. | 2014-07-24 |
20140206056 | INSTALLATION AND METHOD FOR BIOMASS CONVERSION INTO METHANE - The present invention relates to apparatuses, such as small and medium scale processing plants, for conversion of biomass into methane and other high-grade products such as fertiliser. The present invention further relates to methods and uses of the present apparatuses for conversion of biomass into methane and other high-grade products such as fertiliser. Specifically, the present invention relates to an apparatus for conversion of biomass, the apparatus comprises: a) an acidification reactor (1) of a mixed fluid type reactor for microbial hydrolysis and acidification of biomass b) a methane synthesis reactor (2) of a solid bed reactor type for the anaerobic microbial conversion of acidified biomass into c) a methane synthesis reactor (3) of a mixed fluid type reactor for anaerobic microbial conversion of acidified liquid biomass d) a nitrification reactor (4) for aerobic microbial conversion of NH | 2014-07-24 |
20140206057 | NOVEL YEAST STRAINS - There is provided an alkene-producing yeast cell comprising a bacterial fatty acid decarboxylase enzyme, which may comprise the amino acid sequence SEQ ID NO:1 or a functional variant or portion thereof. The alkene may have 15, 17 or 19 carbon atoms. The cell may have a genome comprising a polynucleotide sequence encoding the bacterial fatty acid decarboxylase enzyme. | 2014-07-24 |
20140206058 | SYSTEMS AND METHODS FOR IMPROVING STILLAGE - Systems and methods for improving stillage are disclosed. Stillage may include either whole stillage or thin stillage. The system includes taking the stillage and placing it within a bioreactor with an inoculation of fungi. The fungi may include any of | 2014-07-24 |
20140206059 | Transcriptome Transfer Produces Cellular Phenotype Conversion - The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome. | 2014-07-24 |
20140206060 | CONTINUOUS SONICATION FOR BIOTECHNOLOGY APPLICATIONS AND BIOFUEL PRODUCTION - A system and method for sonication of multiple samples and continuous sonication of an input fluid stream in flow-through arrangements useful for economical breakdown of particulates and organisms present in large volumes with relatively low-power sonication devices such as production of oil from algae. The system includes an electrical wave generator oscillating in the ultrasound range, a vibrating element electrically connected to the electrical wave generator, and a sonication plate that vibrates in certain modes. The sonication plate contains features for mating with sample tubes, and the sample tubes also possess complimentary mating features to those on the sonication plate. A method for sonication of multiple samples includes utilizing mating features to attach tubes to the sonication plate and energizing the sonicator to vibrate the sonication plate. The invention also relates to arrangements for continuous flow-through useful for sonicating large sample volumes. | 2014-07-24 |
20140206061 | BIOACTIVE CARBON NANOTUBE COMPOSITE FUNCTIONALIZED WITH B-SHEET POLYPEPTIDE BLOCK COPOLYMER, AND PREPARATION METHOD THEREOF - The present invention relates to a bioactive carbon nanotube composite functionalized with a β-sheet polypeptide block copolymer by combination self-assembly, which shows excellent water dispersion, and has biological activity so as to be used as stimulus-responsive and adaptable biomaterials or in the manufacture of CNT-based electronic biosensor devices. In addition, the bioactive carbon nanotube composite can be used as a composition for delivery of a biological active material into cells. Further, the application of the interaction between a β-sheet peptide and a carbon-based hydrophobic material is expected to be useful for designing and developing an inhibitor for diseases caused by the abnormal folding of a protein and by biomacromolecular interactions (protein-protein, protein-DNA, and protein-RNA interactions etc). | 2014-07-24 |
20140206062 | Recombinant Influenza Viruses for Vaccines and Gene Therapy - The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus. | 2014-07-24 |
20140206063 | Automated Biological Growth and Dispensing Apparatus - An automated biological growth and dispensing apparatus utilizing a modular growing tank which is removable for replacement by another growing tank. Mechanisms for the delivery of air, water and/or nutrients are adapted to permit the growing tank to be readily coupled and uncoupled for easy and inexpensive replacement. Mechanisms for agitation may be integral and removable with the growing tank or may be adapted for a quick connection and disconnection with the growing tank. The growing tank may be disposable and each new growing tank may be provided as a sealed container including a starting amount of a biomass and/or nutrient. | 2014-07-24 |
20140206064 | BACTERIAL METHODS - A bacterial spore comprising a modified prkC protein, wherein the extracellular domain of the modified prkC protein binds an agent which is not bound by the extracellular domain of the wild-type prkC protein, and wherein the agent is a germinant that stimulates germination of the bacterial spore, or a bacterial spore comprising a modified gerA protein, wherein the gerA protein has been modified such that the spore undergoes germination in the presence of a germinant which does not stimulate germination of a bacterial spore comprising wild-type gerA protein. | 2014-07-24 |
20140206065 | Uracil-Requiring Moorella Bacteria and Transforming-Gene-Introduced Moorella Bacteria - The present invention provides uracil-requiring Moorella bacteria obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase; and transforming-gene-introduced Moorella bacteria obtained by introducing a gene coding for orotidine-5-phosphate decarboxylase and a transforming-gene to a chromosome of the uracil-requiring Moorella bacteria. The present invention was accomplished by uracil-requiring Moorella bacteria, comprising an MTA-D-pF strain that is obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase on a chromosome of Moorella bacteria. | 2014-07-24 |
20140206066 | Syntrophic co-culture of anaerobic microorganism for production of n-butanol from syngas - This invention provides compositions for the production of butanol. Specifically, the compositions of the present invention use syntrophic co-cultures for the production of butanol from syngas. | 2014-07-24 |
20140206067 | METHOD FOR PURIFYING BACTERIAL CELLS - The present invention relates to a process for providing purified bacteria-containing concentrates, comprising at least the steps of adding an aqueous solution to a first bacteria-containing concentrate to provide a bacteria-containing suspension, wherein the volume of the added aqueous solution is in the range of 0.3 liters to 10 liters per liter of said first bacteria-containing concentrate; and concentrating said bacteria-containing suspension to provide a second bacteria-containing concentrate. Further, the present invention relates to the purified concentrates per se. | 2014-07-24 |
20140206068 | PROCESS FOR THE FERMENTATIVE PREPARATION OF L-ORNITHINE - A process for the fermentative preparation of L-ornithine using microorganisms characterized by an increased export of the amino acid. | 2014-07-24 |
20140206069 | BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL ALKANES FROM CARBOHYDRATE FEEDSTOCKS - Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid. | 2014-07-24 |
20140206070 | Vector With Codon-Optimised Genes for an Arabinose Metabolic Pathway for Arabinose Conversion in Yeast for Ethanol Production - The present invention relates to novel expression cassettes and expression vectors, comprising three nucleic acid sequences for araA, araB and araD, each coding for a polypeptide of an L-arabinose metabolic pathway, in particular, a bacterial L-arabinose metabolic pathway. The invention particularly relates to expression cassettes and expression vectors, comprising codon-optimised nucleic acid sequences for araA, araB and araD. The invention further relates to host cells, in particular modified yeast strains containing the expression cassettes or expression vectors and expressing the polypeptides for the L-arabinose metabolic pathway, in particular, for the bacterial L-arabinose metabolic pathway. When using these modified host cells, arabinose is more effectively fermented by these cells, in particular into ethanol. The present invention is therefore relevant, inter alia, in connection with the production of biochemicals from biomass, such as bioethanol for example. | 2014-07-24 |
20140206071 | METABOLICALLY ENGINEERED YEASTS FOR THE PRODUCTION OF ETHANOL AND OTHER PRODUCTS FROM XYLOSE AND CELLOBIOSE - The present invention provides yeast cells that produce high concentrations of ethanol, culture media and bioreactors comprising the yeast cells, and methods for making and using the yeast cells in efficiently producing ethanol. | 2014-07-24 |
20140206072 | METHODS AND SYSTEM FOR OBTAINING ALGAL BIOMASS AND CULTIVATION MEDIUM - The present invention relates to a method for obtaining algal biomass, a system for obtaining algal biomass and a cultivation medium for cultivating algae. The method comprises the step of culturing algae in a culturing medium having a pH above 8 such that lipid accumulation and/or carbohydrate accumulation is increased, wherein the medium is a saline medium. Preferably, the pH of the medium is in the range of 8-11, preferably 8.5-11, more preferably 9-11 and most preferably 10-11. | 2014-07-24 |
20140206073 | MICROFLUIDIC SYSTEM FOR NUCLEIC ACID ANALYSIS - A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers. | 2014-07-24 |
20140206074 | CARTRIDGE FOR CONDUCTING A CHEMICAL REACTION - A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber. | 2014-07-24 |
20140206075 | VOLTAGE GATED METAL-ENHANCED FLUORESCENCE, CHEMILUMINESCENCE OR BIOLUMINESCENCE METHODS AND SYSTEMS - In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied current, surface plasmons in “just-continuous” low resistance films are sparsely available for fluorophore dipole coupling and hence the enhanced fluorescence is gated as a function of the applied current. | 2014-07-24 |
20140206076 | MICRO-FLUIDIC DEVICE - Embodiments described herein provide micro-fluidic systems and devices for use in performing various diagnostic and analytical tests. According to one embodiment, the micro-fluidic device includes a sample chamber for receiving a sample, and a reaction chamber for performing a chemical reaction. A bubble jet pump is structured on the device to control delivery of a fluid from the sample chamber to the reaction chamber. The pump is fluidically coupled to one or more chambers of the device using a fluidic channel such as a capillary. A valve may be coupled to one or more chambers to control flow into and out of those chambers. Also, a sensor may be positioned in one or more of the chambers, such as the reactant chamber, for sensing a property of the fluid within the chamber as well as the presence of a chemical within the chamber. | 2014-07-24 |
20140206077 | PROCESSING BIOMASS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is saccharified in a vessel by operation of a jet mixer, the vessel also containing a fluid medium and a saccharifying agent. | 2014-07-24 |
20140206078 | Culture Flask - A culture flask comprising a culture chamber in a flask body comprising an even bottom wall with a growth surface on the top side, an even cover wall at a section from the bottom wall, and side walls that bridge the distance between the margins of the bottom wall and cover wall, an opening that is in adjacent regions of a side wall and the even cover wall at a distance from the bottom wall, and a hollow cylindrical flask neck that is connected to the margin of the opening and is aligned at a sharp angle to the growth surface so that the serological pipette, a scraper, a cannula or another elongated device for adding or removing material can be placed on the rear corners of the growth surface from the outside through the flask neck. | 2014-07-24 |
20140206079 | MICROWELL PLATE - A microwell plate comprises a skirt and frame portion having a top surface and a bottom surface, and having a plurality of holes; and a well and deck portion comprising a plurality of wells integrated with a planar deck; wherein the well and deck portion is overmolded or adhered onto the skirt and frame portion such that the plurality of wells extends through the plurality of holes in the top surface of the skirt and frame portion; and wherein the well and deck portion is formed from a thermoplastic composition including a poly(aliphatic ester)-polycarbonate comprising soft block ester units, derived from monomers comprising an alpha, omega C | 2014-07-24 |
20140206080 | COMPOSITION AND METHOD FOR DELIVERY OF LIVING CELLS IN A DRY MODE HAVING A SURFACE LAYER - The present invention generally relates to compositions and methods of delivering living cells in a dry mode, wherein the compositions include a surface layer disposed on the outer surface of the composition that is permeable to carbon dioxide and oxygen. The compositions may be used to deliver living cells to a delivery point without the use of expensive refrigerants such as dry ice or liquid nitrogen. | 2014-07-24 |
20140206081 | VARIABLE DOMAINS OF CAMELID HEAVY-CHAIN ANTIBODIES DIRECTED AGAINST GLIAL FIBRILLARY ACIDIC PROTEINS - The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents. | 2014-07-24 |