28th week of 2011 patent applcation highlights part 49 |
Patent application number | Title | Published |
20110172336 | FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS - To provide a composition comprising a fluorocopolymer such as an ethylene/tetrafluoroethylene copolymer which can be produced at a relatively low temperature, and its production process. | 2011-07-14 |
20110172337 | Processes and Apparatus for Continuous Solution Polymerization - The disclosure provides a plant for the continuous solution polymerization of a feed comprising one or more olefin monomers in a solvent, e.g., hydrocarbon solvent, in which the plant comprises means for separating solvent from the polymer including a flash tank and a vacuum devolatilizer. The plant also includes in a first aspect stabilizer addition means for adding a stabilizer to the concentrated polymer fines at a location downstream of the flash and upstream of the vacuum devolatilizer. In another aspect the plant comprises means to add a molten stabilizer to the polymer at a location downstream of the reactors. | 2011-07-14 |
20110172338 | PROCESSING ADDITIVE, MOLDING COMPOSITION MASTERBATCH OF PROCESSING ADDITIVE AND MOLDING ARTICLE - The present invention provides a processing additive which can bring about improvements in moldability at Mooney viscosity levels at which the dispersibility in a melt-processable resin is high and which further can work at reduced addition levels. The present invention is a processing additive comprising a fluoropolymer having an acid value of not lower than 0.5 KOH mg/g. | 2011-07-14 |
20110172339 | RUBBER COMPOSITION - It is to provide a high-elasticity rubber composition having a good workability while preventing the deterioration of fracture resistance of rubber and capable of reducing rubber burning as far as possible by using a vulcanization accelerator having a retarding effect equal to or more than that of the conventional vulcanization accelerator without using a retarder such as CTP possibly causing the deterioration of rubber properties after the vulcanization and problems such as blooming and the like. The rubber composition according to the invention is characterized by comprising a rubber component, a sulfenamide-based vulcanization accelerator represented by a formula (I), a phenolic resin, a methylene donor and sulfur. | 2011-07-14 |
20110172340 | SILICONE RUBBER COMPOSITIONS - A silicone rubber composition comprising an organopolysiloxane having a viscosity of at least 250,000 mPa·s at 25° C., treated filler and a curing agent is described. The composition is substantially free of reinforcing silica fillers and the filler comprises calcium carbonate treated with a treating agent having the formula: R | 2011-07-14 |
20110172341 | THERMALLY CONDUCTIVE POLYAMIDES WITH DIATOMACEOUS EARTH - The present invention relates to thermoplastic molding compositions, comprising | 2011-07-14 |
20110172342 | INK COMPOSITION - Provided is an ink composition including a metallic pigment, a metallic-pigment-fixing resin component containing poly(methyl methacrylate), and an organic solvent, but not including poly(isobutyl methacrylate). | 2011-07-14 |
20110172343 | HYDROPHOBIC PRECIPITATED SILICA FOR DEFOAMER FORMULATIONS - Hydrophobic precipitated silicas with a high pH and low silanol group density, a process for preparing them and their use, particularly in deformer formulations. | 2011-07-14 |
20110172344 | MODIFIED CONJUGATED DIENE-BASED POLYMER, METHOD FOR PRODUCING THE SAME, MODIFIED CONJUGATED DIENE-BASED POLYMER COMPOSITION, AND TIRE - There is provided a modified conjugated diene-based polymer having a silyl group substituted with one or more alkoxy groups, and one or more nitrogen atoms on the chain ends of a conjugated diene-based polymer, the modified conjugated diene-based polymer being obtained by polymerizing a conjugated diene compound, or copolymerizing a conjugated diene compound with an aromatic vinyl compound, by using a polyfunctional anionic polymerization initiator prepared from a polyvinyl aromatic compound and an organolithium compound in a range of a molar ratio (the polyvinyl aromatic compound/the organolithium compound) of from 0.05 to 1.0, so as to obtain the conjugated diene-based polymer, and by reacting a living polymer end of the conjugated diene polymer with the compound having a silyl group substituted with two or more alkoxy groups, and one or more nitrogen atoms. | 2011-07-14 |
20110172345 | RESIN COMPOSITION - Disclosed is a resin composition having an excellent balance between shortness of curing time and longness of pot life. The resin composition contains (A) an organopolysiloxane having an alkenyl group, (B) an organopolysiloxane having a silicon atom-bonded hydrogen atom, (C) a hydrosilylation catalyst, (D) a silane coupling agent and (E) an unsaturated dicarboxylic acid ester. The component (B) contains (B-1) an organopolysiloxane having a molecular weight of not less than 5,000 but not more than 50,000 and (B-2) an organopolysiloxane having a molecular weight of not less than 100 but not more than 5,000, and the ratio of (B-2) to (B-1) is preferably not less than 0.01% by mass but not more than 20% by mass. | 2011-07-14 |
20110172346 | CROSSLINKABLE COATING COMPOSITIONS CONTAINING POLYURETHANE - An aqueous crosslinkable coating composition that includes a PU polymer and a vinyl polymer bearing carbonyl groups (i.e., a carbonyl-functional vinyl polymer) and/or latex polymer. The composition also preferably includes carbonyl-reactive amine and/or hydrazine functional groups. | 2011-07-14 |
20110172347 | AQUEOUS BINDERS GRANULATED AND/OR FIBROUS SUBSTRATES - Aqueous binders for granular and/or fibrous substrates comprising as active constituents
| 2011-07-14 |
20110172348 | ADHESIVE COMPOSITION AND ADHESIVE CONTAINING THE SAME - It is an object of the present invention to provide adhesive compositions having excellent flexibility, rubber elasticity, mechanical properties, heat resistance and low-temperature properties. | 2011-07-14 |
20110172349 | PHOTOSENSITIVE INSULATING RESIN COMPOSITION, CURED PRODUCT THEREOF AND ABA BLOCK COPOLYMER - A photosensitive insulating resin composition includes a block copolymer, a crosslinking agent, a photosensitive compound, and a solvent. The block copolymer includes a first structural unit shown by a following formula (1) and a second structural unit shown by a following formula (2), | 2011-07-14 |
20110172350 | SILANE-GRAFTED-a-OLEFIN-VINYL ACETATE COPOLYMER CONTAINING CROSSLINKABLE SILYL GROUPS, PROCESS FOR THE PREPARATION THEREOF AND USE FOR THE PREPARATION OF INSULATION OR SHEATH MATERIALS FOR CABLES OR LINES - The present invention is directed to a grafted α-olefin-vinyl acetate copolymer containing crosslinkable silyl groups which is composed of one or more α-olefin-vinyl acetate copolymers as component A, of which at least one, as component A1, has a vinyl acetate content of ≧60% by weight, based on the total weight of the α-olefin-vinyl acetate copolymer A1, and at least one unsaturated silane which contains at least one hydrolysable group and which is grafted on to the one or more α-olefin-vinyl acetate copolymers, as component B. The invention if further directed to a processes and uses for the grafted α-olefin-vinyl acetate copolymer. | 2011-07-14 |
20110172351 | ORGANIC INSULATING MATERIAL, VARNISH FOR RESIN FILM USING THE SAME, RESIN FILM AND SEMICONDUCTOR DEVICE - An organic insulating material includes a prepolymer of a cage structure compound having a polymerizable unsaturated bond-containing group and a cage structure with an adamantane structure as the minimal unit. The prepolymer has a number-average molecular weight of between 2,000 and 500,000 based on polystyrene and measured by gel permeation chromatography. The prepolymer includes unsaturated bonds produced by reaction between the polymerizable unsaturated bonds and the unreacted polymerizable unsaturated bonds. The prepolymer has a residue rate of unreacted polymerizable unsaturated bonds of between 20% and 80%. | 2011-07-14 |
20110172352 | RIGID-MATRIX COMPOSITION-GRADIENT COPOLYMERS WHICH ARE SOLUBLE AND/OR DISPERSIBLE IN WATER AND IN ORGANIC SOLVENTS - The invention relates to composition-gradient copolymers, comprising:
| 2011-07-14 |
20110172353 | PROPYLENE-BASED BLOCK COPOLYMER, COMPOSITION CONTAINING THE COPOLYMER, AND MOLDED PRODUCTS OBTAINED THEREFROM - To provide a propylene-based block copolymer which has high melt viscoelasticity, excellent balance between rigidity and impact resistance and good molding processablility and is extremely excellent in its molded product appearance, a composition containing the copolymer and molded products obtained therefrom. The propylene-based block copolymer comprises 5 to 80% by weight of a room temperature n-decane-soluble portion (Dsol) and 20 to 95% by weight of a room temperature n-decane-insoluble portion (Dinsol), with the proviso that the total amount of the Dsol and the Dinsol is 100% by weight, and satisfies the following requirements [1] to [3] at the same time: [1] the molecular weight distribution (Mw/Mn) of the Dsol is not less than 7.0 but not more than 30, [2] the molecular weight distribution (Mw/Mn) of the Dinsol is not less than 7.0 but not more than 30, and Mz/Mw thereof is not less than 6.0 but not more than 20, and [3] the pentad fraction (mmmm) of the Dinsol is not less than 93%. | 2011-07-14 |
20110172354 | ETHYLENE-BASED POLYMER COMPOSITIONS FOR USE IN FIBER APPLICATIONS - The present invention relates to particular ethylene-based polymer compositions suitable for use in binder fiber applications. The materials are characterized in having a peak recrystallization temperature in the range of from 85° C. to 110 C, and a Comonomer Distribution Constant (“CDC”) of 55 or greater. The materials are also characterized by having a tan delta value at 0.1 rad/sec from about 15 to 50, and a complex viscosity at 0.1 rad/second of 1400 Pa·sec or less. | 2011-07-14 |
20110172355 | WATER REPELLENT COATING FILM HAVING LOW REFRACTIVE INDEX - To provide a highly hard coating film formed on a substrate, as adhered to the surface of the substrate and having a refractive index of from 1.28 to 1.41 and a contact angle with water of from 90° to 115°. | 2011-07-14 |
20110172356 | BENZOXAZINE-BASED COMPOSITIONS CONTAINING ISOCYANATE-BASED TOUGHENERS - The present invention relates to curable compositions comprising (a) at least one benzoxazine component selected from the group consisting of N-alkyl and N-alkenyl benzoxazines, and (b) a prepolymer produced from a diisocyanate. The compositions are particularly suitable in the production of adhesives and sealants, prepregs and towpregs. | 2011-07-14 |
20110172357 | COMPOSITION FOR FORMING SUBSTRATE, AND PREPREG AND SUBSTRATE USING THE SAME - Disclosed is a composition for forming a substrate, which includes a matrix resin including an epoxy resin and a fluoroepoxy compound introduced into the main chain of the epoxy resin. A prepreg and a substrate using the composition for forming a substrate are also provided. | 2011-07-14 |
20110172358 | FUNCTIONALIZED LATEX POLYMER AND METHOD OF FORMING THE SAME - A method for forming a functionalized latex polymer includes polymerizing a heterogeneous dispersion of water insoluble monomers in water, thereby forming a latex polymer. An at least partially water soluble halogenated non-ionic group is reacted with the latex polymer, whereby a halogen is displaced from the non-ionic group, thereby forming an at least partially water soluble non-ionic group that attaches to the latex polymer. | 2011-07-14 |
20110172359 | Crosslinkable Moulding Composition - A crosslinkable moulding composition comprises: (1) a functionalised isocyanate product having at least six ethylenically unsaturated groups which is the reaction product of (i) an isocyanate component having an isocyanate functionality of two or more, and (ii) an ethylenically unsaturated component having at least one functional group that is reactive with an isocyanate group of the isocyanate component and at least two ethylenically unsaturated groups; and (2) a monomer component comprising a cross-linking monomer having at least two ethylenically unsaturated groups, wherein at least one of an ethylenically unsaturated component (ii) and/or a monomer component (2) are selected to have at least three ethylenically unsaturated groups. The moulding compositions are especially suitable for reinforcement and thermal curing. Example crosslinked resins derived from such moulding compositions are shown to be capable of achieving high heat deflection temperatures, often in excess of 260° C. | 2011-07-14 |
20110172360 | METHODS FOR SYNTHESIZING POLYETHER DIOLS AND POLYESTER DIOLS - Processes for synthesizing polyether diols and polyester diols are provided. The processes include reacting diols and/or diacids in the presence of carbon black. The processes can be used to produce polymers of a variety of molecular weights. | 2011-07-14 |
20110172361 | METHODS FOR SYNTHESIZING POLYTRIMETHYLENE ETHER GLYCOL AND COPOLYMERS THEREOF - Processes for synthesizing polytrimethylene ether glycol and copolymers thereof are provided. The processes include polycondensing diols in the presence of carbon black, and may be used to produce polymers having molecular weights from about 250 to about 5000. | 2011-07-14 |
20110172362 | Process for preparing a polyethylene molding composition - The invention relates to a polyethylene molding composition having a multimodal molar mass distribution particularly suitable for blow molding films having a thickness in the range from 8 to 200 μm. The molding composition has a density at a temperature of 23° C. in the range from 0.948 to 0.953 g/cm | 2011-07-14 |
20110172363 | Multilayered Package with Barrier Properties - The present invention provides compositions useful as a barrier layer in, for example, packaging products. The compositions generally comprise a blend of (i) a polyester material, preferably an aromatic polyester resin such as polyethylene terephthalate (PET) and (ii) a vinyl alcohol material. The blend optionally may further comprise (iii) a polyolefin material (preferably a functionalized polyolefin material, e.g., a BYNEL material); and/or (iv) a polyamide material (preferably an amorphous polyamide material, e.g., a GRIVORY material), that optionally further comprises an oxygen scavenging material. The present invention also provides containers (e.g., containers formed by expansion of preforms) having a multilayered body-forming portion including: a core layer comprising the aforementioned blend, and inner and outer layers of a formable polymer composition. The present invention also provides methods of making such containers. | 2011-07-14 |
20110172364 | Charged Nanoparticles And Method Of Controlling Charge - A core-first method is provided for making a core-shell nanoparticle that includes the following steps: adding to a solvent, a mono-vinyl monomer cross-linked with a cross-linking agent to form the core of the nanoparticle, the core having an average diameter of 5 nanometers to about 10,000 nanometers, and the core having polymer chains with living ends; adding a charge agent comprising a fixed formal charge group onto the living ends of the core to form the shell of the nanoparticle; controlling the charge of the nanoparticle based on the type of charge agent, the quantity of the charge agent, or both the type of charge agent and the quantity of the charge agent. A core-shell nanoparticle is also provided. | 2011-07-14 |
20110172365 | RUBBER WITH RECYCLED CONTENT - Rubber compositions, methods of making rubber compositions and articles comprising the rubber compositions that have crumb rubber particles in the rubber compositions. A cross-linked rubber composition, comprising a diene rubber and a masterbatch material comprising between 50 and 75 wt. % natural rubber and between 25 and 50 wt. % crumb rubber particles, wherein the crumb rubber particles are 40 mesh or smaller. A method for preparing a rubber composition having crumb rubber, the method comprising mixing a masterbatch, the masterbatch comprising between 50 and 75 wt. % natural rubber and between 25 and 50 wt. % crumb rubber particles and mixing the masterbatch with a diene rubber. | 2011-07-14 |
20110172366 | OLEFIN/AROMATIC VINYL COPOLYMER, PROCESS FOR PRODUCTION THEREOF, RESIN COMPOSITIONS CONTAINING THE COPOLYMER, AND STRETCHED PRODUCTS OF THE COPOLYMER - The present invention relates to such a copolymer comprising an olefin and an aromatic vinyl compound that has a syndiotactic structure, high block property and a wide molecular weight distribution. Specifically, it relates to a copolymer comprising an olefin and an aromatic vinyl compound, in which a content of the aromatic vinyl compound is from 1 to 99% by mol; a molecular distribution is 1.7 or more; a signal based on an (olefin-aromatic vinyl compound-olefin) linkage as a node of the copolymer, a signal based on an (aromatic vinyl compound-aromatic vinyl compound-olefin) linkage, a signal based on an (aromatic vinyl compound-aromatic vinyl compound-aromatic vinyl compound) linkage as a block linkage of the aromatic vinyl compound, and a signal based on an (olefin-olefin-olefin) linkage as a block linkage of the olefin are present; an index showing block property of the aromatic vinyl compound component is from 30 to 100%; and a stereoregularity of a repeating unit chain constituted by the aromatic vinyl compound is 80% by mol or more, a method for producing the same, a resin composition, and a stretched product. | 2011-07-14 |
20110172367 | Grafted Polyethylene - A process for grafting hydrolysable silane groups to polyethylene includes reacting polyethylene with an unsaturated silane having at least one hydrolysable group bonded to Si, in the presence of a compound capable of generating free radical sites in the polyethylene. The grafted polyethylene prepared by the process can be shaped into a pipe and crosslinked by water flowing through the pipe. | 2011-07-14 |
20110172368 | Radically Functionalized Olefin-Based Polymer with Reduced Molecular Weight Change and Method - The present disclosure provides a functionalized olefin-based polymer, a process for producing the same, and articles containing the functionalized olefin-based polymer. The functionalized olefin-based polymer includes an olefin-based polymer, and a functional agent grafted to the olefin-based polymer by way of a coagent. The coagent is either a cinnamoyl derivative and/or a cyano-acrylate compound. The presence of the coagent inhibits a change in the molecular weight during radical functionalization of the olefin-based polymer. | 2011-07-14 |
20110172369 | FUNCTIONALIZED POLYMERS AND PROCESSES FOR MAKING SAME - A macromolecule includes at least one polymer chain with at least one functionality. The polymer can include unsaturated mer units and can be provided via anionic and pseudo-living polymerization techniques. In either technique, the functionality can include at least one 5- or 6-membered ring which includes a secondary amine group and at least one additional heteroatom; in the latter technique, the functionality can include a hydrazone radical. Such polymers can be used to provide compositions that also include particulate fillers, such compositions being useful for the production of vulcanizates. | 2011-07-14 |
20110172370 | CATALYST FOR OLIGOMERIZATION OF ETHYLENE, METHOD FOR PREPARATION THEREOF AND PROCESS FOR OLIGOMERIZATION USING IT - The present invention relates to a catalyst for oligomerization of ethylene, comprising a functionalized solid support; a ligand immobilized on the solid support by chemical bonding, wherein the immobilized ligand has the structure (R | 2011-07-14 |
20110172371 | METHOD OF TREATING POLYMER WITH CARBON-CARBON BOND FRAMEWORK AND PRODUCT OBTAINED BY THE TREATING METHOD - A method of treating a polymer includes oxidatively treating the polymer including a carbon-carbon bond framework in a gas atmosphere at a pressure of not less than 5.0 MPa and at a temperature of higher than 140° C. and lower than 200° C. by using oxygen included in the gas atmosphere. | 2011-07-14 |
20110172372 | CURABLE COMPOSITION AND METHOD FOR IMPROVING RECOVERY PROPERTIES AND CREEP PROPERTIES - Disclosed are a curable composition characterized by using a curable composition including an organic polymer (A1) having one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds in which the one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds are silicon-containing functional groups each having three or more hydrolyzable groups on one or more silicon atoms thereof; and a method for controlling the recovery properties, durability and creep resistance of the cured article. Herewith, the present invention provides a curable composition capable of giving a cured article excellent in recovery properties, durability and creep resistance, and a method for controlling the recovery properties, durability and creep resistance of the cured article. | 2011-07-14 |
20110172373 | Equilibration of Siloxanes on Water-Containing Sulphonated Cation Exchange Resins - The invention relates to a process for producing equilibration products of organosiloxanes by rearrangement of the siloxane bond to a cation exchange resin, the organopolysiloxanes thus obtainable, and the use thereof. | 2011-07-14 |
20110172374 | NOVEL SURFACE ACTIVE PREPOLYMERS WITH BOTH FLUORINE-CONTAINING GROUPS AND HYDROPHILIC GROUPS - Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having polymerizable functionality that is complimentary to polymerizable hydrophilic polymers. | 2011-07-14 |
20110172375 | Processes And Apparatus For Continuous Solution Polymerization - Described herein in one embodiment is a plant for the continuous solution polymerization of one or more monomers in a solvent, e.g., a hydrocarbon solvent. In one aspect, the plant comprises a high pressure pump and at least one heat exchanger downstream of the pump. In another aspect a feed is cooled by three heat exchangers which are refrigerated by means of a common three stage compressor. In another aspect, the plant comprises a primary reactor and a secondary reactor arranged to operate in parallel, in which the ratio of volume of the primary reactor to the secondary reactor is in the range of 60:40 to 95:5. In another aspect, a method of defouling a heat exchanger is provided in which the level of liquid refrigerant in the heat exchanger is temporarily lowered. | 2011-07-14 |
20110172376 | PROCESS FOR THE PRODUCTION OF AN ALPHA-OLEFIN POLYMER - The present invention is directed to a process for the production of an alpha-olefin polymer, which process comprises feeding of at least one alpha-olefin to a mechanically stirred bed gas phase reactor containing particles of the alpha-olefin polymer and polymerizing the alpha-olefin in the presence of a catalyst based on a titanium compound and a magnesium compound, an aluminum-alkyl compound and optionally an organosilane donor, in which process an amount of less than 100 ppm of at least one compound selected from the group of ethoxylated amines, fatty acid esters, diethanol amides, ethoxylated alcohols, alkylsulfonates and alkylphosphates is present during the polymerization. | 2011-07-14 |
20110172377 | Gas-Phase Polymerization Process - A process for polymerizing one or more olefins in a gas-phase polymerization reactor is provided. The gas-phase reactor has a fluidized bed and a fluidizing medium. The fluidizing medium has an operating density and an operating velocity. The process includes determining a critical gas velocity and/or determining a critical gas velocity for the polymerization. The operating gas density and/or the operating gas velocity for the fluidizing medium is then adjusted to be less than or equal to its respective critical value. The process includes increasing the bulk density of the fluidized bed. The increase in the fluidized bed bulk density increases productivity without increasing reactor residence time. | 2011-07-14 |
20110172378 | METHOD FOR MANUFACTURING POLYRADICAL COMPOUND AND BATTERY - In the present invention, in order to provide an electrode active material that has a high capacity density and from which a large current can be extracted and to provide a battery that has a high energy density and produces a large output, in a battery comprising at least a cathode, an anode and an electrolyte, a polyradical compound having a partial structure represented by the following general formula (2) is used as an electrode active material for at least one of the cathode and the anode, | 2011-07-14 |
20110172379 | Ziegler-Natta Catalyst Systems and Polymers Formed Therefrom - Processes of forming catalyst systems, catalyst systems and polymers formed therefrom are described herein. The processes generally include providing a first compound including a magnesium dialkoxide, contacting the first compound with a second compound to form a solution of reaction product “A”, wherein the second compound is generally represented by the formula: | 2011-07-14 |
20110172380 | NEW TRANSITION METAL CATALYTIC SYSTEMS AND METHODS FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND a-OLEFINS USING THE SAME - Provided are transition metal catalytic systems for preparing ethylene homopolymers or copolymers of ethylene with α-olefins. More specifically, provided are Group 4 transition metal catalysts, which is characterized in that the Group 4 transition metal catalyst comprises around the Group 4 transition metal a cyclopentadiene derivative, and at least one naphthoxide ligand(s) having aryl substituent(s) that function(s) as an electron donor and serve(s) to stabilize the catalyst system by surrounding an oxygen atom that links the ligand to the transition metal at 2-position, and there is no cross-linkage between the ligands; catalytic systems comprising such transition metal catalyst and aluminoxane cocatalyst or boron compound cocatalyst; and processes for preparing ethylene homopolymers or copolymers of ethylene with α-olefins by using the same. | 2011-07-14 |
20110172381 | HIGHLY ACTIVE METATHESIS CATALYSTS SELECTIVE FOR ROMP AND RCM REACTIONS - The present invention relates to a kind of novel carbene ligands and ruthenium catalysts, which is highly active and selective for ROMP and RCM reactions, respectively. It discloses the significant electronic and steric effect of different substituted carbene ligands on the catalytic activity and stability of corresponding carbene ruthenium complexes; some of novel ruthenium complexes in the invention can be broadly used as catalysts highly effectively and selective for ROMP and RCM reactions. The invention also relates to preparation of new ruthenium catalysts and the uses in metathesis. Moreover, the invention also provides effective methods of making various functional polymers by ROMP reaction in the presence of new ruthenium catalysts. | 2011-07-14 |
20110172382 | Processes And Apparatus For Polymer Finishing And Packaging - Provided are apparatus and methods relating to the finishing line of a continuous solution polymerization plant. In one aspect, an apparatus includes a pelletizer having cooling liquid, e.g., water or aqueous solution, into which is added a pelletization aid. In another aspect, the apparatus comprises means to remove residual polymer particles from the pelletizer cooling liquid. In a further aspect, the apparatus comprises conduits of at least 50 m in length for carrying propellant cooling liquid from the pelletizer to a drying apparatus. The residence time of the pellets in the cooling liquid may be 10 seconds or more. In a further aspect, a drying apparatus is provided for the pellets which comprises first and second drying zones. In a further aspect, a pneumatic conveyor is provided for carrying pellets to a packaging apparatus. In a further aspect, a packaging apparatus is provided comprising a blender silo. | 2011-07-14 |
20110172383 | Vacuum Devolatilizer - Provided is a vacuum devolatilizer for use in a polymer manufacturing or processing plant. The devolatilizer comprises a vacuum chamber having an inlet for a polymer melt, an outlet for a polymer melt, a vacuum port through which volatiles may be removed and a stirrer shaft port for the entry of a stirrer shaft. The stirrer shaft passes through the at least one stirrer shaft port and extends into the vacuum chamber and carries an agitation means. The stirrer shaft seal is associated with each stirrer shaft port for sealing against the stirrer shaft and each stirrer shaft seal has an external portion outside the vacuum chamber. The devolatilizer is provided with a motor located outside of the vacuum chamber for rotating shaft and comprises means for blanketing the external portion of the stirrer shaft seal with a low oxygen content gas or vapor, e.g., nitrogen, helium, steam, or carbon dioxide. | 2011-07-14 |
20110172384 | PHOSPHORUS-CONTAINING EPOXY RESIN AND METHOD FOR SYNTHESIZING THE SAME - A phosphorus-containing epoxy resin and a method for synthesizing the same are disclosed. The method includes the step of catalytically reacting compound (i) with compound (ii) to synthesize the phosphorus-containing epoxy resin having the structure of compound (I). R is methyl or phenyl, and n is the integer from 1 to 9. | 2011-07-14 |
20110172385 | Solvent resistant polymers - What is disclosed relates to polymers that resist dissolution in organic solvents, are vasodilators, and are tunable explosives. These polymers also form solvent resistant coatings and solvent resistant fibers as well as bonding materials. | 2011-07-14 |
20110172386 | THERMO-SHRINKABLE POLYESTER FILM - Disclosed is a thermo-shrinkable polyester film in which shrinkage uniformity is ensured in a shrinking process thus realizing superior quality of the outer appearance without causing a poorly printed state, reducing the production cost of the shrinking process and improving the productivity. | 2011-07-14 |
20110172387 | METHOD FOR INCREASING THE DIFFERENCE BETWEEN THE MELTING TEMPERATURE AND THE CRYSTALLIZATION TEMPERATURE OF A POLYAMIDE POWDER - The present invention relates to a method for reducing the crystallization temperature an the melting temperature of a polyamide powder resulting from the polymerization of at least one predominant monomer, in which the reduction in the crystallization temperature is greater than the reduction in the melting temperature, said method comprising a step of polymerization of said at least one predominant monomer with at least one different minor comonomer polymerized according to the same polymerization process as said at least one predominant monomer, said at least one minor comonomer being chosen from aminocarboxylic acids, diamine/diacid pairs, lactams and/or lactones, and said at least one minor comonomer representing from 0.1% to 20% by weight of the total blend of said monomers(s) and comonomer(s), preferably from 0.5% to 15% by weight of said total blend, preferably from 1% to 10% by weight of said total blend. | 2011-07-14 |
20110172388 | EASILY DYEABLE META-TYPE WHOLLY AROMATIC POLYAMIDE FIBER - There is provided an easily dyeable meta-type wholly aromatic polyamide fiber excellent in dyeability and acid resistance, and having a very small residual solvent content. The components or conditions of the coagulation bath are appropriately adjusted so as to achieve a coagulated form not having a skin core, plasticization drawing is performed at a specific ratio, and after completing a washing step, a dry heat treatment is performed at a specific temperature. | 2011-07-14 |
20110172389 | Separation of Enzymatically Synthesized Polyepicatechin via High Performance Liquid Chromatography - Disclosed is a process for the separation of one or more fractions from a resulting reaction mixture of an enzymatically catalyzed polymerization of flavonoid using HPLC with a varying concentration of organic solvent in the mobile phase. The isolated fractions can be used in numerous applications including as an antioxidant. | 2011-07-14 |
20110172390 | Protein-Proteophore Complexes - The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can be used to deliver the biologically active moiety to its target. | 2011-07-14 |
20110172391 | PROTEIN SPLICING USING SHORT TERMINAL SPLIT INTEINS - The invention provides methods of producing functional split inteins having small N-intein and/or small C-intein. Using these split inteins with their protein trans-splicing and cleavage activities, we provide new and more effective methods of manipulating proteins. They include site-specific addition of synthetic peptides at protein's terminal and internal locations, ligation of synthetic and/or expressed polypeptides, controllable cyclization of synthetic and/or expressed polypeptides, and controllable cleavages of recombinant proteins. These methods have numerous utilities including but not limited to protein fluorescence labeling, fixation on microchips, site-specific PEGylation, and linkage with pharmaceutical molecules. | 2011-07-14 |
20110172392 | METHOD FOR PRODUCING PEPTIDE - The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an —SMe group; (b) allowing the —SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b). | 2011-07-14 |
20110172393 | NOVEL FORMULATIONS WHICH STABILIZE AND INHIBIT PRECIPITATION OF IMMUNOGENIC COMPOSITIONS - The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like. | 2011-07-14 |
20110172394 | IMPLANTABLE MATERIAL FOR THE REPAIR, AUGMENTATION, OR REPLACEMENT OF BONE AND A METHOD FOR THE PREPARATION THEREOF - A method for the preparation of an implantable material for the repair, augmentation or replacement of bone from a fibroin solution, the method comprising the steps of: preparing a gel from the fibroin solution; preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, wherein the step of preparing the gel from the fibroin solution is performed in the presence of phosphate ions. The material may be treated with calcium ionstoform a fibroin-apatite. A further method comprises the step of treating the material with an isocyanate. The invention also extends to a method for the preparation of an implantable material, wherein a regenerated fibroin solution is used. Also, there is an implantable material and an implant. | 2011-07-14 |
20110172395 | SOLUBLE CANOLA PROTEIN ISOLATE PRODUCTION - Canola protein isolates are provided which contain both albumin and globulin protein fractions that are soluble and transparent in an acidic aqueous environment. The canola protein isolates are completely soluble in water at low pH, low in phytic acid and useful in products for human consumption, pet foods and aquaculture. | 2011-07-14 |
20110172396 | SOLUBLE CANOLA PROTEIN ISOLATE PRODUCTION FROM PROTEIN MICELLAR MASS - A soluble canola protein isolate is prepared from canola protein micellar mass by solubilizing the protein micellar mass in a calcium salt solution, preferably a calcium chloride solution, followed by dilution of the resulting canola protein solution. Following removal of the precipitate phytic acid, the aqueous canola protein solution is concentrated, optionally diafiltered, and acidified to a pH of about 2.5 to 4.0 to produce an acidified clear canola protein solution, which may be concentrated, subjected to a colour removal step and dried. The canola protein isolate so formed is soluble, transparent and heat stable in an acid aqueous environment and also is soluble at natural pH, without precipitation of protein. | 2011-07-14 |
20110172397 | ANTI-PSGL-1 ANTIBODIES - Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein Ligand-1. Also disclosed are methods of inducing death of an activated T-cell and of modulating a T cell-mediated immune response in a subject. | 2011-07-14 |
20110172398 | BISPECIFIC BINDING MOLECULES FOR ANTI-ANGIOGENESIS THERAPY - Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a Dll4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and Dll4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same. | 2011-07-14 |
20110172399 | IL-21 ANTAGONISTS - Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, graft versous host disease, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases. | 2011-07-14 |
20110172400 | COMPOSITIONS MONOVALENT FOR CD40L BINDING AND METHODS OF USE - The invention relates to antibody polypeptides that monovalently bind CD4OL. Antibody polypeptides that are monovalent for binding of CD4OL can inhibit CD4OL activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of DC4OL. in one aspect, a monovalent anti-CD4OL antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of DC4OL, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD4OL antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD4OL interactions in an individual and methods of treating diseases or disorders involving CD40/DC4OL interactions, the methods involving administering a monovalent anti-CD4OL antibody polypeptide to the individual. | 2011-07-14 |
20110172401 | Modified FGF-21 Polypeptides and Their Uses - Modified FGF-21 polypeptides and uses thereof are provided. | 2011-07-14 |
20110172402 | CRYSTALLIZING METHOD OF ERYTHROMYCIN - The present invention provides an erythromycin crystallizing method, which comprises using dichloromethane containing solvent as a preparation solvent, and the dichloromethane solution of erythromycin received was gradiently cooled from high temperature down to low temperature, and thus making erythromycin crystallize. According to the method of the present invention, the content of erythromycin A is high, the content of erythromycin A in the erythromycin crystalline is more than 94.5% (HPLC detection method), the content of dichloromethane in the erythromycin crystalline is less than 600 ppm, the content of water in the erythromycin crystalline is less than 2.5%, the microbiological titre of the erythromycin crystalline is more than 940 μ/mg. | 2011-07-14 |
20110172403 | Microfluidic Device Including Purification Column with Excess Diluent and Method - Methods, apparatus, and a system are provided for processing a sample in a fluidic device. The device can include a purification column, an entrance opening to the purification column, an output reservoir, a fluid communication between the purification column and the output reservoir, and an openable and recloseable valve capable of interrupting fluid flow through the fluid communication. Methods of processing samples using such a device are also provided. | 2011-07-14 |
20110172404 | Self-Assembly of Nanoparticles Through Nuclei Acid Engineering - A self-assembly nanodevice formed through nucleic acid engineering is disclosed. The nanodevice may include an array of nanoparticles. The nanodevice may further include a substrate that supports the array of nanoparticles. Each of the nanoparticles may be coordinated with a plurality of nucleic acids that are substantially free of Watson-Crick base-paring with nucleic acids coordinated with other nanoparticles. Methods of forming the nanodevice, as well as the microscopic organization of the nanoparticles are also disclosed. By manipulating the nucleic acids as capping ligands, the inter-particle distance may be extended to a greater range than nanotechnology based on alkyl ligands or nucleic acids base-pairing. | 2011-07-14 |
20110172405 | METHOD FOR SMALL RNA ISOLATION - This invention relates to a simple and rapid method for the extraction and purification of small RNA from a sample solution. Accordingly, a sample is first mixed with an organic solvent to form a mixture containing the solvent. The mixture is applied to a first mineral support for large RNA to bind. The filtrate is collected which contain unbound small RNA, and is mixed with a second organic solvent to form a second mixture containing the second solvent. This second mixture is applied to a second mineral support for small RNA to bind. After a wash step, the small RNA is eluted. Also provided is a method for the isolation of large RNA, by eluting the large RNA from the first mineral support. In addition, total protein is present in the filtrate and can be isolated by a conventional method. | 2011-07-14 |
20110172406 | MOLECULAR STRUCTURE OF RHD NEGATIVE - The present invention relates to a nucleic acid molecular structure representing the Rhesus genes locus comprising the RHD, SMP1 and RHCE genes and/or the Rhesus box(es), preferably the hybrid Rhesus box, the upstream Rhesus bar and/or the downstream Rhesus box. Furthermore, the invention relates to a process for the specific detection of the common RHD negative haplotypes. The invention further relates to the detection of RHD positive hyplotypes in D-negative individuals. Various mutations in the RHD gene have been identified that allow for the development of diagnostic tools. The invention also relates to oligonucleotides, that specifically hybridize to the hybrid box, preferably the breakpoint or breakpoint region or to the upstream and downstream Rhesus boxes. Additionally, the invention relates to kits comprising or employing the above recited compounds of the invention. | 2011-07-14 |
20110172407 | PHENOTYPIC AND GENOTYPIC DIFFERENCES OF MVA STRAINS - The present invention provides kits and methods to screen viral nucleic acids for a profile of genetic deletions and mutations, optionally in combination with one or more assays for viral replication and/or attenuation capacity. | 2011-07-14 |
20110172408 | RECOVERY OF NUCLEIC ACIDS FROM MAGNETIC GLASS PARTICLES - The present invention is a method of separating nucleic acids using a solid phase capable of binding nucleic acids, such as magnetic glass particles, where binding of nucleic acids to the solid phase is enhanced by the presence of an ethylene-amine compound. The invention further includes a reaction mixture for isolating nucleic acids containing an ethylene-amine compound and kits for carrying out the method. | 2011-07-14 |
20110172409 | Method for nucleic acid isolation by solid phase reversible binding of nucleic acids - The invention includes a method for separating polynucleotides, such as DNA, RNA and PNA, from a solution containing polynucleotides by reversibly and non-specifically binding the polynucleotides to a solid surface having a functional amide group-coated surface. The materials containing a solid surface can be in the form of microparticles, fibers, beads, membranes, test tubes, pipette tips or microwells and can further comprise a magnetic core portion. The pH, salt and concentration of crowding reagent, such as polyethylene glycol or alcohol, of the solution is adjusted to levels which result in nucleic acid binding to the solid surface. The magnetic microparticles with bound polynucleotides are separated from the solution under mild alkaline conditions and the nucleic acids are eluted from the magnetic microparticles. Solutions having different nucleic acid concentrations can be normalized by restricting the availability of the solid phase surface. | 2011-07-14 |
20110172410 | ANTIVIRAL NUCLEOSIDES - 4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process. | 2011-07-14 |
20110172411 | PROCESS FOR SEPARATION OF CA- OR MG-SULFITE SPENT LIQUOR TO YIELD CRYSTALLINE XYLOSE - A process for the separation of a xylose-containing, lignosulphonate-containing Ca-sulfite spent liquor is provided. The process comprises a first step of: (A) chromatographic separation of the Ca- or Mg-sulfite spent liquor using a single pass through a batch-type long resin bed chromatography column having a strong acid cation exchange resin as a separation medium. The ratio of the bed length:mean resin bead diameter of the column is 10,000-40,000. This step yields •a first xylose-rich fraction having a xylose content 50-70 wt. % based on dry solids and • a lignosulphonate-rich fraction. The process further comprises a step of: (B) crystallizing xylose from the first xylose rich fraction by using a crystallization method comprising (i) boiling crystallization; (ii) cooling crystallization or (iii) a combination of (i) and (ii) to obtain a first batch of crystalline xylose and a first xylose run-off. The process provides a simplification of existing methods, and at the same time allows advantages such as improved xylose yield and improved xylose purity. | 2011-07-14 |
20110172412 | REDUCIBLE POROUS CRYSTALLINE HYBRID SOLID FOR THE SEPARATION OF MIXTURES OF MOLECULES HAVING DIFFERENT DEGREES AND/OR A DIFFERENT NUMBER OF UNSATURATIONS - The present invention relates to reducible porous crystalline solids, constituted of a metal-organic framework (MOF), for the separation of mixtures of molecules having different unsaturation degrees and/or a different number of unsaturations with a selectivity that can be adjusted by controlling the reduction of the MOF. | 2011-07-14 |
20110172413 | PURIFICATION METHOD OF LACTONE COMPOUNDS CONTAINING UNSATURATED ALKYL GROUP BY EXTRACTION WITH SILVER ION SOLUTION - The present invention relates to a method for separating and purifying a lactone compound with an unsaturated alkyl group from a lactone compound with a saturated alkyl group which is an analog thereof. More specifically, the present invention relates to a method for effectively separating a lactone compound with an unsaturated alkyl group such as FK506 at high purity by extraction with a silver ion (Ag | 2011-07-14 |
20110172414 | ISOXAZOLINE COMPOUND AND PESTICIDE - A pesticide, particularly an insecticide or an acaricide, including a substituted isoxazoline compound of formula (1) or a salt thereof: | 2011-07-14 |
20110172415 | NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP - It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist. | 2011-07-14 |
20110172416 | AMIDINE DERIVATIVE - Provision of a novel amidine derivative or a pharmaceutically acceptable salt thereof having an activated blood coagulation factor X-inhibitory activity. A compound represented by the formula (I) | 2011-07-14 |
20110172417 | Heterogeneous Copper Nanocatalyst and Manufacturing Methods Thereof - This invention relates to a heterogeneous copper nanocatalyst composed of copper nanoparticles immobilized on a boehmite support, a method of preparing the same, and the use thereof. The copper nanocatalyst composed of the copper nanoparticles supported on boehmite exhibits excellent performance in a Huisgen cycloaddition reaction and an A3 coupling reaction of aldehyde, amine and alkyne. The copper nanocatalyst is able to be prepared in a large scale and shows superior reactivity even when used in a small amount under mild conditions without an additive in an organic reaction. This heterogeneous catalyst is easy to separate and reuse after the reaction. | 2011-07-14 |
20110172418 | ANTISENSE RESTENOSIS COMPOSITION AND METHOD - The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having a phosphorus-containing backbone linkages, and spanning the start codon of a human c-myc mRNA. Also disclosed are novel antisense compounds and compositions, and a method for assaying the effectiveness of antisense delivery and uptake to a target vessel region. | 2011-07-14 |
20110172419 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES - The invention is directed to a process for the preparation of cyclic carbamates of formula | 2011-07-14 |
20110172420 | SULFONAMIDE DERIVATIVES OF POLYCYCLIC DYES USED FOR ANALYTICAL APPLICATIONS - The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes according to the invention are used especially to label analytes, for example to label biomolecules. | 2011-07-14 |
20110172421 | N-(alpha-AROMATIC GROUP-SUBSTITUTED-2-NITRO-4,5-DIALKOXYBENZYLOXYCARBONYL)AMINE COMPOUND AND PROCESS FOR PRODUCING THE SAME - An object of the present invention is to provide a novel photobase generator which can sensitively generate a base even by h-ray in place of a conventional 2-nitro-4,5-dimethoxybenzyloxycarbonylamine compound. Disclosed is an N-(α-aromatic group-substituted-2-nitro-4,5-dialkoxybenzyloxycarbonyl)amine compound represented by the following general formula (I). | 2011-07-14 |
20110172422 | Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds - The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds. | 2011-07-14 |
20110172423 | CYCLIC PHOSPHAZENE COMPOUNDS AND USE THEREOF IN ORGANIC LIGHT EMITTING DIODES - An organic light-emitting diode comprising at least one cyclic phosphazene compound, a light-emitting layer formed from at least one matrix material and at least one emitter material, wherein the at least one matrix material comprises at least one cyclic phosphazene compound, the use of cyclic phosphazene compounds in organic light-emitting diodes and a device selected from the group consisting of stationary visual display units, mobile visual display units and illumination units comprising at least one inventive organic light-emitting diode, and selected cyclic phosphazene compounds and processes for preparing them. | 2011-07-14 |
20110172424 | NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF - Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof are disclosed. These preparation processes are simple and have better practicality. | 2011-07-14 |
20110172425 | NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES - The present invention relates to a novel water based process for the preparation of substituted diphenylmethyl piperazines of Formula I and pharmaceutically acceptable salts | 2011-07-14 |
20110172426 | AROMATIC MONOMER- AND CONJUGATED POLYMER-METAL COMPLEXES - A halogenated aromatic monomer-metal complex useful for preparing a polymer for electronic devices such as a light-emitting diode (LED) device is described. The aromatic monomer-metal complex is designed to include a linking group that disrupts conjugation, thereby advantageously reducing or preventing electron delocalization between the aromatic monomer fragment and the metal complex fragment. Disruption of conjugation is often desirable to preserve the phosphorescent emission properties of the metal complex in a polymer formed from the aromatic monomer-metal complex. The resultant conjugated electroluminescent polymer has precisely controlled metal complexation and electronic properties that are substantially or completely independent of those of the polymer backbone. | 2011-07-14 |
20110172427 | PROCESS FOR PREPARING CERTAIN CINNAMIDE COMPOUNDS - This invention relates to a new synthesis, intermediates and precursors leading to a mixture of the compounds 11 and 12 as shown below. It also relates to the resolution of the stereoisomeric mixture to provide in substantial stereochemical purity compound 12. The synthesis of the invention involves preparation of compound 7 and compound 10 as shown below and their reaction to prepare a mixture of compound 11 and compound 12. | 2011-07-14 |
20110172428 | METHODS FOR THE PREPARATION OF INDAZOLE-3-CARBOXYLIC ACID AND N-(S)-1-AZABICYCLO[2.2.2]OCT-3-YL-1H-INDAZOLE-3-CARBOXAMIDE HYDROCHLORIDE SALT - The present invention provides novel methods for preparing indazole-3-carboxylic acid 2, a key starting material for the manufacture of agonists or partial agonists of the nicotinic α-7 receptor, such as N—(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 13. Nicotinic α-7 receptor agonists and partial agonists are being useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders. The present methods are useful for preparing indazole-3-carboxylic acid on scaled-up levels. | 2011-07-14 |
20110172429 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT - The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR | 2011-07-14 |
20110172430 | METHOD FOR THE CONTINUOUS PRODUCTION OF AN AMINE USING AN ALUMINUM-COPPER CATALYST - Process for the continuous preparation of an amine by reaction of a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary and secondary amines at a temperature in the range from 60 to 300° C. in the presence of a catalyst comprising copper oxide and aluminum oxide, wherein the reaction takes place in the gas phase and the catalytically active composition of the catalyst before reduction with hydrogen comprises PS from 20 to 75% by weight of aluminum oxide (Al | 2011-07-14 |
20110172431 | PROCESS FOR PRODUCING 1-SUBSTITUTED TRANS-4-(SUBSTITUTED AMINO) PIPERIDIN-3-OL - A process is provided for producing a 1-substituted trans-4-(substituted amino)piperidin-3-ol represented by formula (III-1): | 2011-07-14 |
20110172432 | METHOD FOR THE SYNTHESIS OF HETEROGENEOUS PALLADIUM CATALYSTS, CATALYSTS OBTAINED AND USE OF SAME - The invention relates to the field of chemistry, especially organic chemistry, and more specifically the field of heterogeneous palladium catalysts used to catalyse chemical reactions involving the formation of carbon-carbon bonds. The invention also relates to a method for synthesising a heterogeneous palladium catalyst that can catalyse a C—C coupling reaction, the method essentially including steps of providing a solid substrate onto which groups of formula —PR | 2011-07-14 |
20110172433 | NOVEL IMINO DERIVATIVES, METHODS FOR PRODUCING THE SAME AND INSECTICIDES CONTAINING THE SAME - [Technical Problem] To provide a novel imino derivative capable of being an insecticide compound having excellent characteristics such as sustained effects and broad spectrum. | 2011-07-14 |
20110172434 | DERIVATIVES OF HETEROCYCLES WITH 5 MEMBERS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS - The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) | 2011-07-14 |
20110172435 | Treatment Of Inflammatory Bowel Disease - Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I | 2011-07-14 |