28th week of 2011 patent applcation highlights part 48 |
Patent application number | Title | Published |
20110172235 | SUBSTITUTED TRIAZOLOPHTHALAZINE DERIVATIVES - This invention relates to novel substituted triazolophthalazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering selective α5 receptor partial or full inverse agonists. | 2011-07-14 |
20110172236 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS - A series of substituted aryl sulfone derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, calcium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, diabetic neuropathy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, sleep disorder, bipolar disorder and stroke, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. | 2011-07-14 |
20110172237 | QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS - The invention provides named compounds of formula (I), wherein R4 is a N-substituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for’ the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed. | 2011-07-14 |
20110172238 | BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS - Compounds represented by formula I: | 2011-07-14 |
20110172239 | Compounds, Compositions and Methods for the Treatment of Amyloid Diseases and Synucleinopathies such as Alzheimer's Disease, Type 2 Diabetes and Parkinson's Disease - Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment. | 2011-07-14 |
20110172240 | FATTY ACID FUMARATE DERIVATIVES AND THEIR USES - The invention relates to Fatty Acid Fumarate Derivatives; compositions comprising an effective amount of a Fatty Acid Fumarate Derivative; and methods for treating or preventing cancer, a metabolic disorder or neurodegenerative disorder comprising the administration of an effective amount of a Fatty Acid Fumarate Derivative. | 2011-07-14 |
20110172241 | Benzazole analogues and uses thereof - The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, | 2011-07-14 |
20110172242 | TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS - A method of treating exposure to organophosphate agents through the use of compounds comprising tetrahydroindolone and arylpiperazine moieties. | 2011-07-14 |
20110172243 | USE OF AZAPERONE FOR REDUCING ANTIBIOTIC USAGE - The present invention relates to a method for the reduction of antibiotic usage in animals through the use of orally administered azaperone. | 2011-07-14 |
20110172244 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY - The invention provides compounds, of Formula I: pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119. | 2011-07-14 |
20110172245 | HETEROCYCLIC COMPOUND AND USE THEREOF - Provided is a heterocyclic compound showing strong Raf inhibitory activity. A compound represented by the formula | 2011-07-14 |
20110172246 | 1-(2-PHENOXYMETHYLPHENYL)PIPERAZINE COMPOUNDS - The invention relates to compounds of formula I: | 2011-07-14 |
20110172247 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention | 2011-07-14 |
20110172248 | SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME - Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2011-07-14 |
20110172249 | METHOD FOR IMPROVING ABSORBABILITY OF PREPARATION, AND PREPARATION HAVING IMPROVED ABSORBABILITY - The present invention provides a method for improving absorbability of the active ingredient of an enteric polymer coated preparation, which includes using an organic acid. | 2011-07-14 |
20110172250 | ISOTOPICALLY ENRICHED PYRIMIDIN-5-YL ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS - Provided herein are | 2011-07-14 |
20110172251 | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists - The present invention relates to methods of treating the underlying dysregulation of the emotional functionality of mental disorders (i.e. affect instability—hypersensitivity—hyperaesthesia—dissociative phenomena— . . . ) using compounds and compositions of compounds having D4 and/or 5-HT2A antagonistic, partial agonistic or inverse agonistic activity. The invention also relates to methods comprising administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) compounds having D4 antagonistic, partial agonistic or inverse agonistic activity and/or (ii) compounds having 5-HT2A antagonistic, partial agonistic or inverse agonistic, and/or (iii) any known medicinal compound and compositions of said compounds. The combined D4 and 5-HT2A antagonistic, partial agonistic or inverse agonistic effects may reside within the same chemical or biological compound or in two different chemical and/or biological compounds. | 2011-07-14 |
20110172252 | TRIAZOLO[4,5-D]PYRAMIDINE DERIVATIVES AND THEIR USE AS PURINE RECEPTOR ANTAGONISTS - Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning. | 2011-07-14 |
20110172253 | SYNERGISTIC ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS USING CURCUMINOIDS OR METHYLXANTHINES - The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation. | 2011-07-14 |
20110172254 | FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES - Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described. | 2011-07-14 |
20110172255 | Condensed N-Heterocyclic Compounds and their Use as CRF Receptor Antagonists - The present invention provides compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF). | 2011-07-14 |
20110172256 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE - Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. | 2011-07-14 |
20110172257 | (POLY) AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS - The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamide, or alkyl-urea or alkyl-sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: —R represents hydrogen or C | 2011-07-14 |
20110172258 | INDENE DERIVATIVES AS PHARMACEUTICAL AGENTS - Compounds of formula (Ia): | 2011-07-14 |
20110172259 | DOSAGE FORM CONTAINING OXYCODONE AND NALOXONE - The present invention concerns a dosage form comprising oxycodone and naloxone which is characterized by specific in vivo parameters such as t | 2011-07-14 |
20110172260 | METHODS OF PROVIDING WEIGHT LOSS THERAPY IN PATIENTS WITH MAJOR DEPRESSION - Disclosed are methods of providing weight loss therapy, particularly for patients suffering from major depression. | 2011-07-14 |
20110172261 | DIBENZO[f,h]ISOQUINOLINE DERIVATIVES - A group of novel dibenzo[f,h]isoquinoline derivatives as shown in the specification. Also disclosed are methods of using the compounds for treating a disease associated with NO overproduction, cancer, or viral infection. | 2011-07-14 |
20110172262 | COMPOSITIONS AND METHODS FOR TREATING EPILEPSY - Compositions and methods for treating epilepsy and epileptic syndromes are described herein. The compositions and methods include therapeutically effective amounts of one or more dimebolins, or pharmaceutically acceptable salts thereof. | 2011-07-14 |
20110172263 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS - Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma. | 2011-07-14 |
20110172264 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS - Provided herein are novel and selective high affinity α3β4 nicotinic acetylcholine receptor ligands and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, drug addiction or pain using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods for modulating a nicotinic acetylcholine receptor (nAChR). In still other embodiments, provided herein are methods of selectively antagonizing receptors such as, for example, the α3β4 nicotinic acetylcholine receptor using the compounds and compositions disclosed herein. | 2011-07-14 |
20110172265 | Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors - The present invention relates to fused pyrrolidino-cyclopropane derivatives according to formulae (I) to (IV) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-HSD-1) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions. | 2011-07-14 |
20110172266 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS - The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase). | 2011-07-14 |
20110172267 | TSH receptor antagonizing tetrahydroquinoline compounds - The present invention relates the use of a compound, a pharmaceutical composition, compounds and a kit for treating or preventing disorders in a mammal responsive to TSH receptor mediated pathways, including disorders such as hyperthyroidism, Graves' disease, Graves Ophthalmopathy, Graves' associated pretibial dermopathy, nodular goitre and thyroid cancer comprising administering to said mammal an effective amount of a tetrahydroquinoline compound of Formula (I) or an pharmaceutically acceptable salt thereof. | 2011-07-14 |
20110172268 | MECHANISM-BASED SMALL-MOLECULE PARASITE INHIBITORS - Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I-IV. | 2011-07-14 |
20110172269 | ANTIOXIDANT COMBINATIONS FOR USE IN FEED RATIONS TO INCREASE MILK PRODUCTION AND MILK FAT - The present invention provides a combination of antioxidants that effectively stabilize different types of fats utilized in a ruminant diet. When included in a ruminant feed ration or water source, the antioxidant combination typically increases nutrient digestion, such as fiber and protein, improves rumen fermentation, improves microbial growth, improves microbial efficiency, increases milk production and/or milk fat, improves antioxidant status of the ruminant, and attenuates the negative effects of some fats in the ruminant animal. | 2011-07-14 |
20110172270 | 2-'4(PHENYLAMINO)-PIPERIDIN-1-YL!-N-PHENYL-ACETAMINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY - 1,4-disubstituted piperidine compounds of general formula (I) wherein the substituents are defined in claim | 2011-07-14 |
20110172272 | BENZISOXAZOLES - The present invention relates to novel fatty acid esters of the reversible Iloperidone metabolite P-88-8991, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them. | 2011-07-14 |
20110172273 | METHODS OF TREATING MYELODYSPLASTIC SYNDROMES USING LENALIDOMIDE - Methods of treating, preventing and/or managing myelodysplastic syndromes are disclosed. Specific methods encompass the administrations of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidin-2,6-dione in combination with 5-azacytidine. | 2011-07-14 |
20110172274 | FLUORO-SUBSTITUTED 3,4-DIARYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDINE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY - This invention concerns fluorinated 3,4-diaryl-4,5-dihydro-1H-pyrazole-1-carboxamidine derivatives as cannabinoid-CB | 2011-07-14 |
20110172275 | PYRROLE COMPOUNDS - The present invention relates to a compound represented by the formula: | 2011-07-14 |
20110172276 | CARBOXAMIDE COMPOUND AND USE OF THE SAME - A carboxamide compound represented by the formula (I): | 2011-07-14 |
20110172277 | PIRFENIDONE THERAPY AND INDUCERS OF CYTOCHROME P450 - The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking. | 2011-07-14 |
20110172278 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS - The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by G protein-coupled receptors, in particular G protein-coupled receptor 120. | 2011-07-14 |
20110172279 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE - The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof. | 2011-07-14 |
20110172280 | Substituted Benzimidazoles - This invention relates to novel substituted benzimidazoles and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound that modulates the GABA | 2011-07-14 |
20110172281 | Anti-Viral Drugs for Treatment of Arenavirus Infection - Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever). | 2011-07-14 |
20110172282 | USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS - This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R | 2011-07-14 |
20110172283 | Tricyclic Indeno-Pyrrole Derivatives as Serotonin Receptor Modulators - The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity). | 2011-07-14 |
20110172284 | METHODS FOR TREATING SPINAL MUSCULAR ATROPHY - Described herein are methods for the identification or validation of compounds capable of causing ribosomal frameshifting and the use of said compounds to produce a stabilized SMNΔEx7 protein and treat Spinal Muscular Atrophy. | 2011-07-14 |
20110172285 | PROTEASOME INHIBITORS - Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a microbial disease and/or inflammation. | 2011-07-14 |
20110172286 | CD44 SPLICE VARIANTS IN NEURODEGENERATIVE DISEASES - There is provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression of ribonucleic acid (RNA) encoded by a nucleic acid, wherein the nucleic acid is selected from a group that includes a contiguous nucleotide sequence being at least 90% homologous to at least 20 nucleotides of: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, or any combination thereof. There is further provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression and/or activity of a polypeptide, wherein the sequence of the polypeptide is selected from a group that includes a contiguous amino acid sequence being at least 90% homologous to at least 10 amino acid of: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or any combination thereof. | 2011-07-14 |
20110172287 | COMPOSITIONS AND METHODS FOR INHIBITING TUMOR GROWTH AND METASTASIS - Disclosed are compositions and methods useful in the reduction of p11 protein activity in cancer cells. P11 protein is demonstrated to affect plasmin production and activity, MMP activity, plasminogen activation, antiangiogenic plasmin fragment production, cell invasion, tumor development and metastasis. Compositions that modulate levels of p11 either up or down are demonstrated to be effective in reducing tumor development. Also disclosed are cancer treatment methods that employ compositions that modulate p11 activity and clonal cell lines and assays useful for the identification of compositions that modulate p11 activity. | 2011-07-14 |
20110172288 | Compositions and Methods for the Identification, Assessment, Prevention and Therapy of Thymic Lymphoma or Hamartomatous Tumours - The subject matter relates to newly discovered nucleic acid molecules and proteins associated with thymic lymphoma and hamartomatous tumors. Compositions and methods for detecting, characterizing, preventing, and treating human thymic lymphoma and hamartomatous tumors are provided. | 2011-07-14 |
20110172289 | MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS - Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs. | 2011-07-14 |
20110172290 | Isoforms of eIF-5A: Senescence-induced eIF5A; Wounding-induced elF-5A; Growth elF-5A; and DHS - The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS. | 2011-07-14 |
20110172291 | RNA INTERFERENCE FOR THE TREATMENT OF GAIN-OF-FUNCTION DISORDERS - The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease. | 2011-07-14 |
20110172292 | ANTIDOTE OLIGOMERS - The present invention relates to antidote oligomeric compounds (oligomers), which target nucleotide based therapeutics in vivo, thereby providing a method of controlling the bioavailability and therefore the therapeutic activity and/or side effects of nucleotide based therapeutic in vivo. | 2011-07-14 |
20110172293 | Methods and Compositions for Modulating Angiogenesis - The present invention provides compositions comprising antisense nucleic acids that reduce miR-126 levels in an endothelial cell. The present invention provides compositions comprising a target protector nucleic acid. The present invention provides methods of modulating angiogenesis in an individual, the methods generally involving administering to the individual an effective amount of an agent that increases or that decreases the level of miR-126 in endothelial cells of the individual. | 2011-07-14 |
20110172294 | CYCLOHEXENYL NUCLEIC ACIDS ANALOGS - The present disclosure describes cyclohexenyl nucleic acid analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, cyclo-hexenyl nucleic acid analogs are provided, having one or more chiral substituents, that are expected to be useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. | 2011-07-14 |
20110172295 | METHODS AND COMPOSITIONS FOR THE REGULATION OF microRNA PROCESSING - Provided herein are methods and compositions for the regulation of microRNA processing. The invention presents methods for inhibiting the activity of a Lin-28-like polypeptide and methods for treating a subject with cancer comprising administering to a subject with cancer a compound that inhibits the activity of a Lin-28-like polypeptide. Compositions comprise isolated polynucleotides and expression cassettes comprising the same that promote the processing of at least one of a regulated primary microRNA transcript by Drosha and a regulated precursor microRNA by Dicer when introduced into or expressed in a cell. Compositions and methods are also provided for the selective suppression of target polynucleotides by a microRNA based on the level of expression of a Lin-28-like polypeptide within a cell. | 2011-07-14 |
20110172296 | MODULATION OF TRANSFORMING GROWTH FACTOR-BETA 1 EXPRESSION - Provided are compounds capable of inhibiting expression of TGF-beta 1 and compositions containing same as well as methods using such compounds for treating fibrotic diseases including the reduction of scarring resulting from wound healing. | 2011-07-14 |
20110172297 | Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof - The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of Formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of Formula (I) as AMPA modulators. | 2011-07-14 |
20110172298 | INDICATION OF USE OF ERDOSTEINE AS ANTIDOTE IN A LARGE NUMBER OF INTOXICATIONS, ESPECIALLY IN HEAVY METALS LIKE LEAD OR MERCURY, AND PARACETAMOL - Indication of use of erdosteine as antidote in a large number of intoxications, especially in heavy metals like lead or mercury, and paracetamol. Indication of use of erdosteine as prophylaxis for intoxications. Erdosteine can be administered per os or intravenous, using a solution obtained with sodium hydrogen carbonate and bidistilled water. | 2011-07-14 |
20110172299 | THERAPEUTIC SUBSTITUTED CYCLOPENTANES - Disclosed herein are compounds represented by a formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed. | 2011-07-14 |
20110172300 | NOVEL EPIGALLOCATECHIN GALLATE TRIMER AND ALPHA-GLUCOSIDASE INHIBITOR CONTAINING EPIGALLOCATECHIN GALLATE POLYMER - The present invention provides an α-glucosidase inhibitor containing a novel epigallocatechin gallate trimer and an epigallocatechin gallate polymer. Decomposition of starch derived from a meal and sugar derived from a polysaccharide can be suppressed by α-glucosidase inhibitory action, thus suppressing absorption. A food and drink excellent in α-glucosidase inhibitory action for suppressing sugar absorption and further for preventing diabetes for a long time can be provided by adding the α-glucosidase inhibitor to a food and drink. | 2011-07-14 |
20110172301 | Use of anti-oxidant compounds for muscle recovery - The present invention describes the use of a composition comprising a compound according to formula (1) to retain or restore muscle health: formula (1) wherein: R can be H, OH or CH | 2011-07-14 |
20110172302 | METHODS OF TREATING MEIBOMIAN GLAND DYSFUNCTION - The present invention includes methods for treating Meibomian gland dysfunctions. The invention also includes methods for improving tear lipid composition, for treating abnormal Meibomian gland secretion and for normalizing Meibomian gland secretions. | 2011-07-14 |
20110172303 | DEACETYLASE INHIBITORS AND USES THEREOF - The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds. | 2011-07-14 |
20110172304 | Sex Attractant of White Peach Scale and Attraction Method - Provided is an attractant of white peach scale capable of simplifying the synthesis of a sex pheromone of white peach scale and suppressing attraction of a parasitoid wasp which is a natural enemy of the white peach scale. More specifically, provided is a sex attractant of white peach scale comprising at least (R,Z)-(+)-3,9-dimethyl-6-isopropenyl-3,9-decadienyl priopionate and a geometric isomer (R,E)-(+)-3,9-dimethyl-6-isopropenyl-3,9-decadienyl priopionate at a weight ratio ranging from 80:20 to 40:60. In addition, provided is a method for attracting white peach scale by using said attractant. | 2011-07-14 |
20110172305 | Endocannabinoids for Enhancing Growth and Development in Infants - The present invention relates to a method for promoting infant feeding, growth or development comprising administering to an infant a formula or a pharmaceutical composition comprising an endocannabinoid in an amount sufficient to promote feeding, growth or development. The present invention also relates to an infant formula comprising an enhanced amount of an endocannabinoid. The infant formula of the invention may be in a powder form or in a liquid form. The infant formula or the pharmaceutical composition may further comprise an endocannabinoid-promoting compound. | 2011-07-14 |
20110172306 | CREATINE ESTER PRONUTRIENT COMPOUNDS AND FORMULATIONS - The present invention describes a method for providing creatine to an animal, which includes receiving a creatine ester by the animal. The creatine ester is suitable for being modified by the animal to form creatine. | 2011-07-14 |
20110172307 | ANTIMICROBIAL COMPOSITIONS FOR USE ON FOOD PRODUCTS - The present invention relates to antimicrobial compositions, and specifically antimicrobial compositions that are useful at sanitizing food products. The compositions of the present invention include octanoic acid, an acidulant, a coupling agent, an optional buffer, and water. The compositions of the present invention are composed of GRAS or food additive raw materials. | 2011-07-14 |
20110172308 | Antagonsim of PGF2a Receptor to Treat Hyertension Characterized by Activation of the Renin-Angiotensin-Aldosterone System - The present invention relates to methods for identifying candidate therapeutics for hypertension. The invention further provides a method for treating hypertension and/or decreasing atherogenesis by administration of an inhibitor of PGF | 2011-07-14 |
20110172309 | GALENIC FORMULATIONS OF ORGANIC COMPOUNDS - The present invention relates to a solid oral dosage form comprising a therapeutically effective amount of aliskiren or a pharmaceutically acceptable salt thereof, and wherein the active incredient is present in an amount of more than 46% by weight based on the total weight of the oral dosage form. | 2011-07-14 |
20110172310 | DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS - The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them. | 2011-07-14 |
20110172311 | Compounds For Treating Human Papillomavirus - Methods and compositions for treating human papillomavirus infections are described. | 2011-07-14 |
20110172312 | TREATMENT OF LEIGH SYNDROME AND LEIGH-LIKE SYNDROME WITH TOCOTRIENOL QUINONES - The present invention relates to methods of treating Leigh Syndrome and Leigh-like Syndrome with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease. | 2011-07-14 |
20110172313 | Image quality in the eye - Pharmaceutical compositions or dietary supplements are provided containing lutein, zeaxanthin, or mixtures thereof in amounts effective to improve image quality in the human eye. Methods are also provided for reducing higher order wavefront aberrations in the human eye to improve image quality by administering to a person in need of such treatment an effective amount of lutein, zeaxanthin or mixtures thereof. | 2011-07-14 |
20110172314 | AMPHIPHILIC BRANCHED POLYMERS AND THEIR USE AS EMULSIFIERS - The present invention relates to amphiphilic branched copolymers, methods for their preparation, emulsions comprising such copolymers and their use as emulsifiers. The polymers are responsive by nature, by forming non-covalent bonds between monomer residues upon applying external stimuli. In a preferred embodiment of the copolymer, the copolymer can be used to stabilise emulsions and the emulsion droplets can be reversibly aggregated and de-aggregated. | 2011-07-14 |
20110172315 | COMPOSITION FOR CRYOPRESERVATION OF CELLS AND TISSUES - A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In examples, ε-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In examples for foods or pharmaceuticals, the ε-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration. | 2011-07-14 |
20110172316 | Method and Apparatus for Reducing CO2 in a Stream by Conversion to a Syngas for Production of Energy - A system and method for reducing the CO | 2011-07-14 |
20110172317 | SULFONATED POLYARYLENE COMPOUNDS, MEMBRANE MATERIAL MADE THEREFROM, METHOD FOR THE PRODUCTION THEREOF AND USE - The invention relates to the field of polymer chemistry and relates to sulfonated polyarylene compounds such as can be used for example in ion exchange membranes in fuel cells, as well as a method for the production thereof and the use thereof. The object of the present invention is to disclose hydrolytically and thermally resistant sulfonated polyarylene compounds with a defined degree and position of sulfonation, from which membrane materials with an improved resistance to hydrolysis can be produced. The object is attained through sulfonated polyarylene compounds according to at least one of the general formulas (I)-(IV). | 2011-07-14 |
20110172318 | METHOD OF DECREASING ACETALDEHYDE LEVEL IN A MOLDED ARTICLE - There is provided a method ( | 2011-07-14 |
20110172319 | HIGH-CONCENTRATE MASTERBATCHES COMPRISED OF MULTIFUNCTIONAL COMPOUNDS FOR POLYESTER EXPANDING PROCESS - The composition and the preparation of multifunctional high-concentrate masterbatches for production of expanded materials of aromatic polyesters are disclosed in this invention. The masterbatch includes a thermoplastic wax having a vicat softening temperature not higher than 100° C. and a high-percentage of a multifunctional compound, wherein the preparation involves a) a low temperature process with a masterbatch temperature lower than 100° C. before cooling and b) cooling without contact of the mixture with water during the whole process. The high-concentrate masterbatch can be applied in production of expanded materials of polyester. | 2011-07-14 |
20110172320 | POLY VINYL CHLORIDE FOAM PROMOTERS - The density of rigid foamed articles made by the thermal decomposition of a blowing agent in a vinyl chloride polymer is reduced by the use of a tin based blowing agent activator(s). The tin based activator also reduces the activation temperature of a chemical blowing agent, allowing for more optimal evolution of gas during plastic processing. Dibutyl tin oxide or tin maleates are superior activators of vinyl chloride polymer blowing agents. | 2011-07-14 |
20110172321 | HOTMELT VISCOSITY STABILIZER - The invention relates to innovative viscosity stabilizers for hotmelts, to melt-viscosity-stable hotmelts comprising these viscosity stabilizers, to a process for preparing them and to their use. | 2011-07-14 |
20110172322 | Branched Low and Medium Density Polyethylene - The invention relates to a long chain branched medium and low density polyethylene having a combination of the following properties: a) a density of from 0.910 to 0.945 g/cm | 2011-07-14 |
20110172323 | PHOTOPOLYMERIZABLE COMPOSITIONS - Disclosed are photopolymerizable compositions suitable for uses such as dental composite resins, and that comprise (A) a radical-polymerizable monomer, (B) a photopolymerization initiator that comprises (B1) an α-diketone compound, (B2) a photoacid generating agent, (B3) an aromatic amine compound, and (C) an organic filler containing a phthalate ester fluorescent agent. | 2011-07-14 |
20110172324 | NOVEL WATER SOLUBLE POLYIMIDE RESIN, ITS PREPARATION AND USE - The present invention relates to a novel water soluble polyimide resin, which contains a hydrophilic functional group such as —OH, —COOH to increase the solubility of the polyimide resin in alkali aqueous solution, and is suitable for using as an insulation film in electronic and photoelectric products. The present invention also relates to preparation and use of the above polyimide. | 2011-07-14 |
20110172325 | ANTIFOULING COATING COMPOSITION, ANTIFOULING COATING FILM FORMED USING THE COMPOSITION, COATED ARTICLE HAVING THE COATING FILM ON THE SURFACE, AND ANTIFOULING TREATMENT METHOD TO FORM THE COATING FILM - An object of the present invention is to provide a composition for forming an environment friendly antifouling coating film that is unlikely to cause a hairline crack and like coating film defects even when immersed in seawater for a long time, and that prevents or inhibits attachment of slime. An antifouling coating composition of the invention comprises: (A) a triorganosilyl ester-containing copolymer obtained by a mixture of (a) a triorganosilyl (meth)acrylate monomer represented by a general formula (1): R | 2011-07-14 |
20110172326 | BIODEGRADABLE POLYMER COMPOSITION WITH CALCIUM CARBONATE AND METHODS AND PRODUCTS USING SAME - Described herein are biodegradable compositions, methods for making these compositions, and applications using these compositions. In one embodiment, a process of manufacturing paper or other products is provided using a composition comprising a mixture of 25% to 80% calcium carbonate along with a biodegradable biopolymer matrix made from renewable resources including polylactic acid (“PLA”), soy proteins, polyhydroxyalkanoate (“PHA”), polyhydroxybutyrate (“PHB”), and/or starch from corn, wheat, tapioca, potatoes, or similar renewable resource products. | 2011-07-14 |
20110172327 | METHOD OF TREATING AND COMPOUNDING FILLERS - A method of treating filler can include the steps of providing the filler, disposing silica within the filler so that a bulk density of the filler is approximately 24 to 26 pounds per cubic feet, forming a silane compound that includes silane and paraffin wax, and combining the silane compound with the filler. | 2011-07-14 |
20110172328 | POWDER COATING COMPOSITION AND PROCESS OF MANUFACTURE - The present invention provides a powder coating composition comprising
| 2011-07-14 |
20110172329 | FLAME RETARDANT POLY(TRIMETHYLENE TEREPHTHALATE) COMPOSITION - Improved flame retardant polytrimethylene terephthalate compositions are provided by including a bis(diphenyl phosphate) flame retardant additive. | 2011-07-14 |
20110172330 | POLYPROPYLENE OXIDE-CONTAINING POLYETHERS AND MIXTURES THEREOF WITH POLY(METH)ACRYLATES AS POWDER COATING LEVELING AGENTS - The invention relates to powder coating leveling agents comprising (a) at least one polypropylene oxide-containing polyether having a weight-average molecular weight of more than 1000 g/mol and a polypropylene oxide fraction of more than 75% by weight, and optionally (b) at least one poly(meth)acrylate. The invention further relates to the preparation of such leveling agents and to their use in powder coating materials, and also to powder coating materials comprising the leveling agents. | 2011-07-14 |
20110172331 | Reactive monomer-dispersed silica sol and production method thereof, and curable composition and cured article thereof - A reactive monomer-dispersed silica sol having high stability by reducing the solid acidity of the surfaces of the colloidal silica particles contained in the reactive monomer-dispersed silica sol, and a production method thereof, and a curable composition using the reactive monomer-dispersed silica sol, and a cured article in which the deterioration, the degradation, or the like of the polymer is suppressed. A reactive monomer-dispersed silica sol containing a colloidal silica particle in which an alkaline earth metal ion is bonded to a surface of the colloidal silica particle. | 2011-07-14 |
20110172332 | WOOD SUBSTITUTE MATERIAL AND ITS USE - The invention relates to a wood substitute material for wood-encased pencils, comprising the following ingredients: 15-3.0% by weight of at least one polymeric binder, 50-80% by weight of at least one organic filler, 0-20% by weight of at least one inorganic filler, 0.5-5% by weight of at least one adhesion promoter, 1-30% by weight of at least one wax, 0-10% by weight of at least one colour pigment, and 0-10% by weight of at least one additive, the at least one adhesion promoter forming a chemical bond between the at least one polymeric binder and the at least one organic filler, a ratio of the at least one adhesion promoter and the at least one wax in the range from 1:2 to 1:6 being formed, and the sum of organic and inorganic filler being not more than 80% by weight. | 2011-07-14 |
20110172333 | Methods of producing fiber clay sclupting material, fiber clay products and fiber clay sculpting material - The present invention involves the creation of fiber clay sculpting material and use of the material as a medium, including techniques for producing the material and non-fired and non-dried clay products. A fiber clay sculptural material is disclosed, while alternative embodiments may encompass fiber clay products. The fiber clay sculptural material in accordance with the present invention may incorporate fiber material such as paper, nylon or fiberglass. One embodiment of the invention disclosed is a method of producing fiber clay sculpting material, featuring the provision of an acrylic emulsion, adding the acrylic emulsion to fiber clay and mixing the acrylic emulsion with the fiber clay to form an acrylic fiber clay sculpting material. A fiber clay product may be produced from the disclosed methods. Further embodiments of the invention are fiber clay sculpting materials made of fiber clay and an acrylic emulsion mixed with the fiber clay to form an acrylic fiber clay sculpting material. The material may be used to from non-fired or non-dried fiber clay products. | 2011-07-14 |
20110172334 | WEATHERABLE POLYOLEFIN NANOCOMPOSITES - A method is disclosed concerning discovering how the use of an additive in a polyolefin compound affects the weatherability of that compound, Applying that technique, a weatherable polyolefin nanocomposite is disclosed, which contains UV stabilizers that filter wavelengths in a range influenced by presence of organoclay in the nanocomposite. | 2011-07-14 |
20110172335 | OXYGEN SCAVENGERS, COMPOSITIONS COMPRISING THE SCAVENGERS, AND ARTICLES MADE FROM THE COMPOSITIONS - The present disclosure relates to oxygen scavenging molecules, compositions comprising the molecules, and articles made from the compositions. | 2011-07-14 |