28th week of 2012 patent applcation highlights part 39 |
Patent application number | Title | Published |
20120178078 | Methods and Compositions for Nucleic Acid Detection - The present application relates to Multicomponent Nucleic Acid Enzymes (MNAzymes), which may be used for detecting, identifying and/or quantifying targets. More particularly, this application provides methods of designing and making more reliable MNAzymes, as well as compositions comprising MNAzyme components and methods of using MNAzymes. | 2012-07-12 |
20120178079 | Human Bocavirus and Methods of Diagnosis and Treatment - Human parvovirus, genus | 2012-07-12 |
20120178080 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOSITIONS AND THEIR USE IN BIOASSAYS - Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith. | 2012-07-12 |
20120178081 | Methods of Labeling Cells, Labeled Cells, and uses Thereof - Methods of detecting nucleic acids, proteins and cells including methods of detecting two or more nucleic acids, proteins and cells in multiplex bDNA assays, are provided. Assays may be conducted at least in vitro, in vivo, in cellulo, and in situ. Nucleic acids are detected, through cooperative hybridization that results in specific association of a label probe system with target nucleic acids. Embodiments are directed to concurrent detection of one or more nucleic acids and/or one or more proteins. The detected proteins may be intracellular or external markers on the surface of the cell. Detection of protein components is accomplished by use of specific antibodies and a label probe system and/or coated microparticles which bind to the outside surface of specific cells and contain specific probes that can be detected using the same label probe system. Compositions, kits, and systems related to the methods are also described. | 2012-07-12 |
20120178082 | METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH RISK OF AGGRESSIVE PROSTATE CANCER - The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer. | 2012-07-12 |
20120178083 | SPECIFIC MARKER Lmx1a ON DOPAMINERGIC NEURONS - The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation. | 2012-07-12 |
20120178084 | INTEGRATED ACTIVE FLUX MICROFLUIDIC DEVICES AND METHODS - The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e. Polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. | 2012-07-12 |
20120178085 | METHOD FOR EVALUATION OF CULTURED CELLS, AND METHOD FOR SCREENING OF BIOMARKER - Disclosed are novel means by which evaluation of cultured cells and screening of biomarkers can be attained without consuming the cultured cells. A method for evaluating cultured cells according to the present invention comprises culturing cells in a serum-free medium, and measuring at least one nucleic acid released from the cells into the culture medium. A method for screening of a biomarker according to the present invention comprises culturing cells in a serum-free medium, and measuring a nucleic acid(s) released from the cells into the culture medium. Nucleic acid used as an indicator is e.g. microRNA. | 2012-07-12 |
20120178086 | REDUCTIVE RELEASE PROBES CONTAINING A CHEMOSELECTIVELY CLEAVABLE ALPHA-AZIDOETHER LINKER AND METHODS OF USE THEREOF - Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like. | 2012-07-12 |
20120178087 | Genotyping Assay to Predict Gamma Glutamyl Hydrolase (GGH) Activity - Single nucleotide polymorphisms (SNPs) in the gene encoding gamma glutamyl hydrolase (GGH) associated with reduced GGH activity are disclosed. The primary SNP is a change from a cytosine to a thymine at a position corresponding to nucleotide 511 of Genbank sequence accession no. NM 003878. Methods and kits for detecting these SNPs are provided, along with primers useful in detecting these SNP and for amplifying portions of the GGH gene containing these SNPs. | 2012-07-12 |
20120178088 | THE TUMOR SUPPRESSOR KILLIN - The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies. | 2012-07-12 |
20120178089 | MATERIALS AND METHODS FOR THE IDENTIFICATION OF DRUG-RESISTANT CANCERS AND TREATMENT OF SAME - Disclosed herein are diagnostic methods for identifying cancer and predicting drug resistance. The assays involve the detection of NEK2 gene expression alone or in combination with other genes or clinical factors. The test is suitable for diagnosing and monitoring treatment of subjects having or suspected of having a neoplastic disease, such as multiple myeloma. The disclosure also relates to inhibitors of NEK2 for the treatment of cancer, including drug-resistant multiple myeloma. | 2012-07-12 |
20120178090 | METHOD FOR ISOLATING NUCLEIC ACIDS AND PROTEIN FROM A SINGLE SAMPLE - The present invention comprises a method of isolating nucleic acid and protein from the same sample with solid supports, wherein nucleic acid and protein components contained in the sample become bound to distinct solid supports. The invention also allows for kits for isolating nucleic acid and protein from the same sample and for use of the method of isolating nucleic acid and protein for the analysis and/or comparison of mRNA and/or protein expression and/or their correlation to genomic information. | 2012-07-12 |
20120178091 | Assay Cartridges and Methods of Using the Same - Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge. | 2012-07-12 |
20120178092 | Method for the Replication, Amplification or Sequencing of a DNA Template - Methods for replicating, amplifying or sequencing a deoxyribonucleic acid with a φ29 type DNA polymerase are disclosed, along with kits for carrying out the methods. | 2012-07-12 |
20120178093 | METHODS OF ASSESSING A RISK OF CANCER PROGRESSION - Methods and kits that use miRNA expression to predict the development of brain metastases in non-small cell lung cancer patients are disclosed. | 2012-07-12 |
20120178094 | Method for Categorizing Circulating Tumor Cells - The present invention provides method for categorizing circulating tumor cells (CTCs) using various cellular markers and revealing or non-revealing assays which provide beneficial insights for clinical staging and therapy decision making in cancer patients. | 2012-07-12 |
20120178095 | CARDIOMYOCYTE DIFFERENTIATION - This invention provides a method for testing a factor for cardiogenicity which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence and absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and measuring the differentiation in the presence and absence of the factor. This invention also provides a method for identifying a cardiogenic factor, which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2 cells or serum-free extracellular medium therefrom, and identifying the factor that affects the differentiation of human embryonic stem (hES) cells to cardiomyocytes in the presence or absence of the factor. | 2012-07-12 |
20120178096 | METHOD FOR ISOLATING WEAKLY INTERACTING MOLECULES FROM A FLUIDIC SAMPLE - Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps. | 2012-07-12 |
20120178097 | METHODS AND DESIGN OF MEMBRANE FILTERS - The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time. | 2012-07-12 |
20120178098 | WHOLE BLOOD ASSAY FOR MEASURING AMPK ACTIVATION - A method of sample analysis is provided. In certain embodiments, the method comprises: a) labeling cells of a blood sample using an antibody that specifically binds to phospho-AMPK or a phosphorylated target thereof, to produce a labeled sample; and b) measuring antibody binding by a population of blood cells of the labeled sample using flow cytometry. In particular embodiments, the method may further comprise, prior to the labeling step: contacting blood with a test agent ex vivo or in vivo; and comparing the evaluation to results obtained from a reference sample of blood cells. | 2012-07-12 |
20120178099 | HIGHLY FLUORESCENT CARBON NANOPARTICLES AND METHODS OF PREPARING THE SAME - Highly fluorescent carbon nanoparticles (FCNs), with tunable emission colours of particle size between 1-10 nm also stable in solid form with high quantum yield (>5%) and its method of synthesis thereof yielding said carbon nanoparticles in milligram to gram scale in high synthesis yield (>80%). The present invention also provides for highly fluorescent carbon nanoparticle solution doped with heteroatom (such as oxygen, nitrogen) and its method of synthesis favoring yield of the said doped carbon nanoparticles of even smaller size ranging from 1-5 nm with narrow size distribution, and also provides for functionalized FCNs that are non-toxic, functional, soluble and stable fluorescent carbon nanoparticles with retained fluorescence for variety of end uses in biomedics, imaging applications, and detection techniques. | 2012-07-12 |
20120178100 | Serum Markers Predicting Clinical Response to Anti-TNF Alpha Antibodies in Patients with Psoriatic Arthritis - The invention provides tools for management of patients diagnosed with psoriatic arthritis, specifically, prior to the initiation of therapy with an anti-TNFα agent. The tools are specific markers and algorithms of predicting response to therapy based on standard clinical primary and secondary endpoints using serum marker concentrations. In one embodiment the baseline levels of VEGF, prostatic acid phosphatase, and adiponectin are used to predict the response at Week 14 after the initiation of therapy. In another embodiment, the change in a serum protein biomarker after 4 weeks of therapy is used such as MDC, lipoprotein a, and beta2-microglobulin. | 2012-07-12 |
20120178101 | DEVICE, METHOD, AND SYSTEM FOR QUANTITATIVELY MEASURING A SPECIMEN USING A CAMERA - The present invention relates to a device and method for quantitatively measuring an analyte using a camera. More particularly, to capture the identification code required for obtaining an accurate analysis result for the analyte to be analyzed, to capture the result of the reaction of the analyte using a camera without additional equipment, and to read the identification code and the result of the reaction of the analyte, the device of the present invention comprises: a camera for capturing a camera recognition area of an analyte kit, which contains an analyte reaction result obtained by the reaction of the analyte and an identification code for the analyte kit; an image-processing unit for separating the analyte reaction result image and the identification code image from images of the camera recognition area of the analyte kit captured by the camera; a reading unit for reading the analyte reaction result image and the identification code image; and a control unit for enabling the read result of the analyte reaction result image to be processed using the read result of the identification code image. | 2012-07-12 |
20120178102 | CHARACTERIZATION OF GRANULOCYTIC EHRLICHIA AND METHODS OF USE - The present invention relates, in general, to granulocytic ehrlichia (GE) proteins. In particular, the present invention relates to nucleic acid molecules coding for GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; purified GE S2, S7, S22, S23, C6.1, C6.2, S1, E8, E46#1, and E46#2 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to GE S2, S7, S22, S23, C6.1, C6.2, S1, E8, E46#1, and E46#2 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; a method of detecting nucleic acids encoding GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with ehrlichiosis; therapeutic uses, specifically vaccines comprising S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins or polypeptides or nucleic acids; and methods of preventing or inhibiting ehrlichiosis in an animal. | 2012-07-12 |
20120178103 | DETECTION OF DYSPLASTIC OR NEOPLASTIC CELLS USING ANTI-MCM6 ANTIBODIES - Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of the cervix (both biopsy and smear samples), breast, colon, lung, bladder, skin, larynx, oesophagus, bronchus, lymph nodes and urinary tract (both biopsy and cytology smear samples), in determination of cancerous and pre-cancerous cellular growth abnormality, and cells spun from urine, blood and serum, in determination of haematological malignancies and evidence of metastatic sarcoma and carcinoma. | 2012-07-12 |
20120178104 | Spatial Biomarker of Disease and Detection of Spatial Organization of Cellular Receptors - A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened for therapeutic potential in the assay: a potentially efficacious drug is identified by an ability to modulate an established signature. The receptor distribution signature can be corroborated with an mRNA expression profile of several genes, indicating, for example, metastasis. | 2012-07-12 |
20120178105 | DETECTION OF GLOBOTRIAOSYLCERAMIDE (GLC) IN HUMAN URINE SAMPLES USING AN ANTIBODY SANDWICH - Applicant has developed an assay for the detection of GL3 in human samples using a sandwich based immunoassay in which utilizes a pair of GL3 specific monoclonal antibodies, one for capture and one for detection, to create an antibody “sandwich” around the GL3 ligand. To further increase sensitivity, Applicant has modified traditional sandwich based assays by complexing the capture antibody with GL3 before adding the sample or detector antibody, providing an inhibition based assay. | 2012-07-12 |
20120178106 | ANTIGEN BINDING MOLECULES THAT BIND EGFR, VECTORS ENCODING SAME, AND USES THEREOF - The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function. | 2012-07-12 |
20120178107 | HUMAN ANTIBODIES THAT BIND HUMAN TNFalpha - Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., K | 2012-07-12 |
20120178108 | IMMUNODETECTABILITY - In the present disclosure, there is provided a method for improving the immunodetectability of at least one protein in an optionally diluted sample of blood, serum or plasma, comprising a step of heating the sample to a temperature of 64-85° C. prior to a contact between the sample and at least one affinity ligand for detection and/or quantification of the at least one protein. | 2012-07-12 |
20120178109 | DIAGNOSIS OF A PARASITIC DISEASE SUCH AS LEISHMANIASIS USING RIBOSOMAL PROTEIN EXTRACT (RPE) - The invention relates to a diagnosis method for | 2012-07-12 |
20120178110 | SCREENING OF PROTEIN CANDIDATES - Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides a method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously. PCs are fused to a protein anchor, which is captured by the target/antigen. The captured PCs are evaluated for their expression levels, biophysical properties and affinities using conventional methods. | 2012-07-12 |
20120178111 | METHODS AND COMPOSITIONS FOR THE DETECTION OF LUNG CANCERS - A method of screening for, diagnosing or detecting lung cancer in a subject, the method comprising: a) determining a level of a biomarker or a plurality of biomarkers in a sample from the subject, wherein the biomarker(s) is/are selected from the biomarkers listed in Table 8, and b) comparing the level of each biomarker in the sample with a control; wherein an increased level of any one of the biomarkers compared to the control is indicative that the subject has lung cancer Biomarkers were identified by shot-gun proteomics analysis of lung cancer cell-lines H1688, H520, H460 and H23. These lines are of differing histo-types, and were grown on serum-free media. | 2012-07-12 |
20120178112 | METHOD OF DETECTING SKELETAL MUSCLE DAMAGE - The present invention relates to a method of detecting skeletal muscle damage and to the use of certain proteins and fragments thereof as biological markers (commonly known as “biomarkers”) for such damage. The present invention has particular reference to the detection of muscle toxicity in mammals, particularly humans. | 2012-07-12 |
20120178113 | DETECTION OF IGFBP-4 FRAGMENTS AS A DIAGNOSTIC METHOD - The present invention relates to a method for diagnosing a cardiovascular or cancer disease by detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments in a patient sample. Antibodies specifically recognizing novel epitopes originated by enzyme-dependent cleavage of IGFBP-4 are also disclosed. | 2012-07-12 |
20120178114 | METHODS AND DEVICES FOR DETECTING THROMBIN GENERATION - Methods and devices for detecting thrombin generation are disclosed. Generally, the methods include combining a blood sample with a reagent composition so that reaction of the reagent composition and thrombin, if present in the sample, produces a detectable signal; and detecting the detectable signal. Generally, the devices include a fluid-tight material forming at least one passageway; a first chamber in fluid communication with at least one passageway; and at least one reagent disposed on a surface of or contained in either a chamber or a passageway. In some embodiments, the passageway is configured to permit capillary flow of fluid, while in other embodiments, fluid flow is accomplished through a pump functionally linked to at least one passageway. In some embodiments, the device may further include a signal detector positioned to detect a signal generated in a chamber or passageway. In certain embodiments, the device may further include a microprocessor functionally linked to the signal detector. | 2012-07-12 |
20120178115 | Mutants of Pyrroloquinoline Quinine-Dependent Soluble Glucose Dehydrogenase - The present invention relates to novel mutants of PQQ s-GDH containing an amino acid substitution in position 428 of the protein sequence of the wild type PQQ s-GDH of | 2012-07-12 |
20120178116 | POLYPEPTIDES FOR IDENTIFYING FUNGICIDALLY ACTIVE COMPOUNDS - The invention relates to a combination of polypeptides from phytopathogenic fungi having the biological activity of an aurora kinase and the function of an aurora kinase activator, to nucleic acids coding therefore, to the use of the polypeptides and nucleic acids for identifying modulators of an aurora kinase, to processes for identifying such modulators and to the use of these modulators as fungicides. | 2012-07-12 |
20120178117 | METHOD OF LIPID ASSAY AND REAGENT FOR USE THEREIN - A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability. | 2012-07-12 |
20120178118 | BIOMARKERS FOR MONITORING TREATMENT OF NEUROPSYCHIATRIC DISEASES - Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease, and for monitoring a subject's response to treatment. | 2012-07-12 |
20120178119 | METHOD FOR MEASURING AUTOPHAGY - This invention relates to a method for measuring autophagy in cells, comprising using, as a probe reagent, a single fluorescent protein, to measure a change in fluorescence properties of the fluorescent probe reagent depending on pH changes associated with autophagy, thereby determining the presence or activity of autophagy, wherein the single fluorescent protein is resistant to degrading enzyme activity in the lysosome or vacuole of the cell, it is not denatured or inactivated under acidic to neutral pH environment, and it is capable of changing excitation spectra or fluorescence spectra when located under the environments of acidic region and neutral region. | 2012-07-12 |
20120178120 | MICROPLATE - The present invention relates to a microplate, or microtitration plate, having an invagination consisting of a continuous peripheral channel making it possible to add thereto, in a single introduction step, a liquid acting as an “evaporation curtain”. The invention is also directed to a device comprising such a microplate, to a manufacturing method and to use of such a microplate. | 2012-07-12 |
20120178121 | METHOD TO CHARACTERIZE BLOOD AND RED BLOOD CELLS VIA ERYTHROCYTE MEMBRANE FRAGILITY QUANTIFICATION - An apparatus and method for quantifying RBC fragility via stress-induced hemolysis and subsequent optical and computational analysis. While directed toward applications in blood quality control, the technology could have application in diagnosis. The apparatus comprises: a hemolysis unit; an optical analysis unit; and a computation unit. Similarly, the associated process comprises: a hemolysis step; an optical analysis step; and a computation step. | 2012-07-12 |
20120178122 | APPARATUS AND METHOD FOR ANALYZING BACTERIA - An apparatus for analyzing bacteria is described that includes an analytic sample preparation section for preparing an analytic sample by treating a specimen so as to generate a morphological difference between Gram-negative bacteria and Gram-positive bacteria, a detector for detecting optical information from each particle contained in the analytic sample and an analyzing section for detecting Gram-positive bacteria contained on the basis of the detected optical information. A method for analyzing bacteria is also described. | 2012-07-12 |
20120178123 | ENHANCED LIPID PRODUCTION FROM ALGAE - A method for stimulating enhanced lipid accumulation by algae includes growing algae in a bioreactor medium including nutrients. The algae have an average lipid content that averages a first % of total cell biomass. A stress inducing environmental condition is initiated that keeps the algae alive, stops cell reproduction, and induces the algae to accumulate additional lipids resulting in a second average lipid content that is at least 50% more than the first %. The method can include measuring a lipid concentration of the algae while under the stress inducing environmental condition, harvesting lipids from more than 50% but not all of the algae when the lipid concentration is above a predetermined lipid limit, adding fresh medium to the bioreactor medium having algae not involved in the harvesting therein, and repeating the method, wherein the algae not involved in harvesting serves as a source for new algae growth. | 2012-07-12 |
20120178124 | STEROL SIDE CHAIN-CLEAVING ENZYME PROTEIN AND USE THEREOF - It is an object of the present invention to obtain highly active P450scc enzyme protein which is an important enzyme protein that catalyzes the first step of the biosynthesis of industrially useful steroid hormone. The present invention provides a sterol side chain cleavage enzyme protein having the following physicochemical properties:
| 2012-07-12 |
20120178125 | Mutant Strain of Aspergillus sojae with Enhanced Protease Activity and Preparation Method of Natural Taste Enhancer Using the Same - The present invention relates to a mutant strain of | 2012-07-12 |
20120178126 | METHODS AND MATERIALS FOR INCREASING EXPRESSION OF RECOMBINANT POLYPEPTIDES - The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression. | 2012-07-12 |
20120178127 | Nucleic acid encoding apoptotic anti-ige antibodies - The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders. | 2012-07-12 |
20120178128 | PROCESS FOR PRODUCING CYSTEINE AND/OR GLUTATHIONE FROM CYSTINE EMPLOYING YEAST - The invention provides a process for the conversion of cystine to cystein and/or glutathione comprising contacting cystine with a microorganism. The invention also relates to a yeast extract comprising at least 1.8 mg/g cystein and a yeast autolysate comprising at least 1.3 mg/g cystein. | 2012-07-12 |
20120178129 | GENE SYNTHESIS METHOD - The present invention relates to polymerase chain reaction (PCR)-based methods for the one-step synthesis of nucleic acid molecules, wherein the amplification primers used in said methods are designed such that they have two distinct melting temperatures in order to minimize the competition between polymerase cycling assembly (PCA) and polymerase chain reaction (PCR) amplification in the one-step nucleic acid synthesis and to maximize the emerging full-length amplification, as well as kits for use in such methods. | 2012-07-12 |
20120178130 | REUSABLE PCR AMPLIFICATION SYSTEM AND METHOD - A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field. | 2012-07-12 |
20120178131 | TAL EFFECTOR-MEDIATED DNA MODIFICATION - Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided. | 2012-07-12 |
20120178132 | ENDOGLUCANASES - The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase. | 2012-07-12 |
20120178133 | SYSTEM FOR PRODUCING L-HOMOPHENYLALANINE AND A PROCESS FOR PRODUCING L-HOMOPHENYLALANINE - The present invention relates to a system ( | 2012-07-12 |
20120178134 | ENHANCEMENT OF BIOMASS PRODUCTION BY DISRUPTION OF LIGHT ENERGY DISSIPATION PATHWAYS - The invention provides a method of producing biomass or at least one biomolecule comprising culturing a photosynthetic microorganism that comprises a disrupted Non-Photochemical Quenching (NPQ) process, and isolating biomass or at least one biomolecule from the culture. | 2012-07-12 |
20120178135 | ENHANCED PRODUCTION OF LIPIDS CONTAINING POLYENOIC FATTY ACIDS BY VERY HIGH DENSITY CULTURES OF EUKARYOTIC MICROBES IN FERMENTORS - The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids. | 2012-07-12 |
20120178136 | FERMENTATION PROCESS FOR PRODUCING GLYCOLIC ACID - The present invention relates to a process of fermentation for producing glycolic acid under specific pH conditions with an increase of the pH during fermentation. The invention relates more particularly to a method for producing glycolic acid by fermentation, which comprises culturing a microorganism having glycolic acid producing ability in an appropriate culture medium with a carbon source, and under specific pH conditions with an increase of the pH during fermentation, and recovery of glycolic acid from the culture medium. | 2012-07-12 |
20120178137 | CELL-MEDIATED SILICA SOL-GEL ENCAPSULATION OF LIVING CELLS AND TISSUES - Methods are provided for the encapsulation of living cells with a silica glass layer. The methods comprise adding a sol solution to cells in buffered media, forming a sol-gel layer on the cells and then diluting the media or removing the cells from the media. | 2012-07-12 |
20120178138 | MODIFICATIONS OF PEPTIDE COMPOSITIONS TO INCREASE STABILITY AND DELIVERY EFFICIENCY - The disclosed invention relates to methods of modifying peptide compositions to increase stability and delivery efficiency. Specifically, the disclosed invention relates to methods to increase the stability and delivery efficiency of protein kinase C (PKC) modulatory peptide compositions. A “therapeutic peptide composition” comprises a “carrier peptide” and a “cargo peptide.” A “carrier peptide” is a peptide or amino acid sequence within a peptide that facilitates the cellular uptake of the therapeutic peptide composition. The “cargo peptide” is a PKC modulatory peptide. Peptide modifications to either the carrier peptide, the cargo peptide, or both, which are described herein increase the stability and delivery efficiency of therapeutic peptide compositions by reducing disulfide bond exchange, physical stability, reducing proteolytic degradation, and increasing efficiency of cellular uptake. | 2012-07-12 |
20120178139 | ERYTHROCYTE-BINDING THERAPEUTICS - Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired. | 2012-07-12 |
20120178140 | Modified Clostridial Toxins with Enhanced Targeting Capabilities For Endogenous Clostridial Toxin Receptor Systems - The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins. | 2012-07-12 |
20120178141 | LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME - Briefly described, embodiments of this disclosure include polynucleotides that encode mutant | 2012-07-12 |
20120178142 | Ketoreductases and Uses Thereof - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. | 2012-07-12 |
20120178143 | ALPHA/BETA HYDROLASE-FOLD ENZYMES - The present invention relates to the identification of novel hydrolases in gram positive microorganisms. The present invention provides amino acid sequences for the hydrolase. The present invention provides host cells which comprise nucleic acid encoding the hydrolase. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the hydrolase of the present invention. | 2012-07-12 |
20120178144 | METHOD OF PRODUCING CELLULASE - A method is described for producing cellulase by fermentation wherein the fermentation is conducted using | 2012-07-12 |
20120178145 | VIRUS SCAFFOLD FOR SELF-ASSEMBLED, FLEXIBLE AND LIGHT LITHIUM BATTERY - A variety of compositions that include a metal oxide, films and batteries comprising one or more of the compositions, and methods of making the same. | 2012-07-12 |
20120178146 | BACTERIA CAPABLE OF DEGRADING MULTIPLE PETROLEUM COMPOUNDS IN SOLUTION IN AQUEOUS EFFLUENTS AND PROCESS FOR TREATING SAID EFFLUENTS - This invention relates to new | 2012-07-12 |
20120178147 | MICROBIAL CULTURES AND METHODS FOR ANAEROBIC BIOREMEDIATION - The invention relates to a consortium of microorganisms that can be used to dehalogenate a chemical composition. Methods of use of the same for biomass production and for use of the same in bioremediation are described. | 2012-07-12 |
20120178148 | Detergent Composition - A detergent composition comprising; a subtilisin variant having the amino acid sequence set forth in SEQ ID NO 1, and at least one additional ingredient selected from; i) bleaches selected from percarbonates, persulphates and organic peracids, ii) aminocarboxylates, or iii) sulphonated polymers, or iv) organophosphoric acids or salts thereof and mixtures thereof is provided. Also provided is a detergent composition comprising a subtilisin variant having the amino acid sequence set forth in SEQ ID NO 1, wherein, the detergent composition is at least partially enveloped in a water soluble or water dispersible package. The compositions exhibit good performance on proteinaceous stains, even when formulated at alkaline pHs. A method of removing proteinaceous stains from surfaces comprising such stains is also provided. | 2012-07-12 |
20120178149 | METHOD OF PREPARING PLANT-DERIVED VLPS - Methods of preparing plant-derived virus like particles (VLPs) are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized VLPs, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived VLPs. Alternatively, VLPs may be obtained from plant or plant matter comprising plant-derived VLPs by digesting the plant matter using a cell wall degrading enzyme composition to produced a digested fraction. The digested fraction is filtered to produced a filtered fraction, and the plant-derived VLPs are recovered from the filtered fraction. | 2012-07-12 |
20120178150 | SYSTEM FOR FLUID PERFUSION OF BIOLOGICAL MATTER COMPRISING TISSUE - System for fluid perfusion of biological matter that includes tissue. According to one embodiment, the system may include a storage container for storing the biological matter, a thermal control device for cooling the contents of the storage container, a gas generator for generating a preserving gas, a fluid conduit coupled to the gas generator and insertable into tissue for delivering the preserving gas to the biological matter, and a process controller for controlling the operation of the gas generator and the thermal control device. The gas generator, in turn, may include an electrochemical oxygen concentrator and/or a water electrolyzer for generating the preserving gas. The system may further include a liquid perfusion system that includes a reservoir of liquid perfusate, a fluid delivery conduit for delivering liquid perfusate from the reservoir to the biological matter, and a fluid draining conduit for draining liquid perfusate from the biological matter. | 2012-07-12 |
20120178151 | UNITARY PLASTIC CONDUCTIVITY SENSOR - A contacting-type conductivity sensor includes an electrically-insulative plastic body and a plurality of electrodes. The plurality of conductive electrodes is disposed in the plastic body. Each electrode is constructed of plastic and fused with the electrically-insulative plastic body. A method of manufacturing the conductivity sensor is provided along with a single-use bioreactor employing the sensor. | 2012-07-12 |
20120178152 | MEDICAL HAND-HELD DEVICE - A medical hand-held device is disclosed comprising a test tape unit that can be inserted into a device housing which comprises a test tape provided with a plurality of analytical test elements which can be wound by means of a spool, and a tape drive comprising an electric motor and a gear unit that can be coupled to the test tape unit for winding the test tape forwards in sections, such that the test elements can successively be provided for sample application. The axis of rotation of the electric motor is arranged in a plane extending transversely to the axis of rotation of the spool and that the gear unit has an angle drive to change the direction of the axis. | 2012-07-12 |
20120178153 | pH SENSOR INTEGRATION TO SINGLE USE BIOREACTOR/MIXER - A pH sensing bioreaction system is provided. The system includes a bioreaction container having a plastic wall and a pH sensor attached to the plastic wall. The pH sensor includes a sensor body having a flange that is sealingly attached to the plastic wall. The sensor body has a reference electrolyte therein and a first sensing element disposed in the reference electrolyte. The first sensing element is configured to contact both the reference electrolyte and a sample solution inside the bioreaction container. A second sensing element is positionable into an interior of the bioreaction container. The pH sensor has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container, and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container. | 2012-07-12 |
20120178154 | ORGANIC MATERIAL PRODUCTION SYSTEM USING BIOMASS MATERIAL AND METHOD - An organic material production system using biomass material includes: a hydrothermal decomposition apparatus that causes the biomass material and hot compressed water to countercurrently contact with each other and undergo hydrothermal decomposition, so as to separate the lignin component and the hemicellulose component from a biomass solid residue; a cellulose enzymatic saccharification device that treats, cellulose in the biomass solid residue, so as to enzymatically saccharify the cellulose to a first sugar solution containing hexose; an alcohol fermenter that produces alcohols by fermentation using the obtained first sugar solution; a sulfuric acid decomposition device that decomposes the hemicellulose component in hot water discharged from the hydrothermal decomposition apparatus, which contains the eluted lignin component and the eluted hemicellulose component, so as to decompose the hemicellulose component to a second sugar solution containing pentose; and a second alcohol fermenter that produces, using the second sugar solution containing pentose, alcohols by fermentation. | 2012-07-12 |
20120178155 | ROTATING CELL SEEDING MODULE - An apparatus and method is described for seeding cells on a sample or specimen. The cells may be selectively and locally seeded on an upper and lower surface of a planar sample or specimen or on either or both of an interior luminal surface and exterior surface of a hollow sample or specimen. The apparatus includes a chamber suitable for cell seeding, cell growth, and cell conditioning. | 2012-07-12 |
20120178156 | GENETIC VARIANT OF THE ANNEXIN A5 GENE - The present invention relates to a nucleic acid molecule comprising an annexin A5 (ANXA5) gene regulation element which comprises at least one point mutation, corresponding to nucleotide 186 (G to A), 203 (A to C), 229 (T to C), and 276 (G to A) of SEQ ID NO: 2, a vector comprising the nucleic acid molecule, and a host transformed with the vector. The invention also relates to specific uses, in particular diagnostic uses of the nucleic acid molecules described herein. The invention also relates to haplotyping an ANXA5 gene regulation element from a nucleic acid from an individual which involves determining nucleotides present at positions 186, 203, 229 and 276 of the individual's copy of the ANXA5 gene regulation element, by comparison to SEQ ID NO: 2. | 2012-07-12 |
20120178157 | RECOMBINANT POXVIRUS EXPRESSING HOMOLOGOUS GENES INSERTED INTO THE POXVIRAL GENOME - The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing, an immune response in a living animal, including a human, is provided. | 2012-07-12 |
20120178158 | ADULT ANIMALS GENERATED FROM INDUCED PLURIPOTENT CELLS - The present invention provides methods and compositions for generating and using induced pluripotent stem cells. | 2012-07-12 |
20120178159 | MESENCHYMAL STEM CELLS (MSC) EXPANSION METHODS AND MATERIALS - The subject invention concerns materials and methods for growing and expanding MSC while maintaining their undifferentiated phenotype, self-renewal ability, and/or multi-lineage potential. In one embodiment, a method of the invention comprises i) seeding freshly isolated MSC on a planar surface or a 3-D scaffold and growing the cells under physiological or low O | 2012-07-12 |
20120178160 | Cultivation Of Primate Embryonic Stem Cells - The invention relates to methods for culturing human embryonic stem cells by culturing the stem cells in an environment essentially free of mammalian fetal serum and in a stem cell culture medium including amino acids, vitamins, salts, minerals, transferrin, insulin, albumin, and a fibroblast growth factor that is supplied from a source other than just a feeder layer the medium. Also disclosed are compositions capable of supporting the culture and proliferation of human embryonic stem cells without the need for feeder cells or for exposure of the medium to feeder cells. | 2012-07-12 |
20120178161 | MEDIUM AND CULTURE OF EMBRYONIC STEM CELLS - Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an undifferentiated state. It has now been found that high levels of fibroblast growth factor in a medium together with at least one of gamma aminobutyric acid, pipecolic acid, and lithium, enables pluripotent stem cells to remain undifferentiated indefinitely through multiple passages, even without feeder cells or conditioned medium. Without beta-mercaptoethanol, the medium improves cloning efficiency. Also, a matrix of human proteins can be used to culture the undifferentiated cells without exposing the cells to animal products. Further disclosed are new primate pluripotent cell lines made using the defined culture conditions, including the medium and the matrix. Such new cell lines will have never been exposed to animal cells, animal products, feeder cells or conditioned medium. | 2012-07-12 |
20120178162 | POLYMER MATRICES FOR CELL CULTURE - Synthetic cell culture surfaces, including a hydrophobe modified cellulose or an hydroxylated acrylate polymer composition and optionally including a silica source, cell culture coating and cell culture articles incorporating the composition, and methods of making and using the articles for cell culture, as defined herein. | 2012-07-12 |
20120178163 | Novel tumor necrosis factor receptor homologs and nucleic acids encoding the same - The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptides molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. | 2012-07-12 |
20120178164 | TREATING CARDIOVASCULAR TISSUE - This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue are provided. | 2012-07-12 |
20120178165 | POLYMERIC COATINGS AND METHODS FOR FORMING THEM - The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerisation initiators and a plurality of surface binding groups. Pendant polymers may be grafted from at least some of the polymerisation initiators. | 2012-07-12 |
20120178166 | SIMPLIFIED BASIC MEDIA FOR HUMAN PLURIPOTENT CELL CULTURE - Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS cells from adult individuals under defined, xeno-free conditions are also described. | 2012-07-12 |
20120178167 | Methods for Transfecting Nucleic Acid Into Live Cells - The present invention includes methods for transferring a multigenic phenotype to a cell by transfecting, preferably by phototransfection, and locally transfecting a cell or a cellular process with a laser while the cell is bathed in a fluid medium comprising two or more nucleic acids, thereby introducing the nucleic acid into the interior of the cell. Expression of the nucleic acids results in a multigenic phenotype in the tranfected cell. | 2012-07-12 |
20120178168 | METHOD FOR REGULATING PROTEIN FUNCTION IN CELLS USING SYNTHETIC SMALL MOLECULES - Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein. | 2012-07-12 |
20120178169 | TAL EFFECTOR-MEDIATED DNA MODIFICATION - Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided. | 2012-07-12 |
20120178170 | SAMPLE CONTAINER INTELLIGENT RACK AND LOADING METHOD - An intelligent rack automatically detects the position of a specimen tube within a multiple specimen tube containing rack such as that utilized within automatic specimen processing apparatuses. The rack has a plurality of positions with a moving element located adjacent each position. The moving element, such as a spring, is positioned so that it moves when a specimen tube is placed within an adjacent position. A magnet or other sensor on the moving element interacts with a detector to sense when a particular position has received a specimen tube. A computer controlling the apparatus receives specimen information for each specimen tube and has an identifier for the specimen tube, such as a bar code, scanned into the computer before placement of the specimen tube into a rack position. Removal of the specimen tube from a position on the rack causes correlating removal of specimen tube position information from the computer. | 2012-07-12 |
20120178171 | METHODS OF USING CYANINE DYES FOR THE DETECTION OF ANALYTES - The present invention concerns a method of measuring the concentration of an analyte in an aqueous solution that comprises the steps of: obtaining an aqueous solution containing an analyte, providing a cyanine indicator, placing the aqueous solution in fluid communication with the cyanine indicator, measuring a detectable property change of the cyanine indicator, and comparing the detectable property change of the cyanine indicator with a calibration curve of the detectable property change of samples containing known concentrations of the analyte to determine the concentration of the analyte, wherein the detectable property change is proportional to the concentration of the analyte in said aqueous solution. | 2012-07-12 |
20120178172 | FLUORESCENT POLYMERS OF 7-HYDROXYCOUMARIN COMPOUNDS, CHEMICAL SENSORS COMPRISING THEM, AND POLYMERIZABLE FLUORESCENT COMPOUND OF 7-HYDROXYCOUMARIN - Polymers and copolymers of polymerizable fluorescent compounds of 7-hydroxycoumarin such as Ethyl-2-methacrylate Umbelliferone-4-acetate are provided. In addition, a sensor comprising this polymer notably for detecting and/or assaying nitrated and organophosphorus compounds, explosives, and toxic compounds is provided. | 2012-07-12 |
20120178173 | COMPOSITIONS AND METHODS FOR DETECTION OF EXPLOSIVES - This invention provides polymeric coordination compounds capable of forming three-dimensional microporous metal organic frameworks (MMOFs) that are useful for detection of explosive compounds. The polymeric coordination compounds comprise a repeating unit comprising a transition metal coordinated to at least one binding member of a bidentate binding site on each of two polyfunctional ligands and one binding site of a bis-pyridine exodentate bridging ligand, for example, the repeating unit comprising formula [Zn | 2012-07-12 |
20120178174 | FLUORESCENT PROBE - A compound represented by the formula (I) wherein R | 2012-07-12 |
20120178175 | CWB conductivity monitor - This invention is a method and apparatus for monitoring the concentration of carbon dioxide dissolved in water by means of conductivity. It distinguishes between the conductivity resulting from carbon dioxide and the conductivity resulting from other constituents dissolved in water. It can be used to monitor the quality of demineralized water, boiler feedwater, steam, or condensate in electric power generation and other industrial facilities. It is constructed by adding a column containing weak base anion exchange resin and a conductivity instrument to a typical cation conductivity monitor. A sample of the water to be monitored flows first through a typical cation conductivity monitor, then through a weak base anion exchange column, and then through an additional conductivity instrument. Conductivity measured at the outlet of the weak base anion exchange column will be essentially due to whatever concentration of carbon dioxide is dissolved in the sample because other dissolved constituents that affect conductivity have been essentially removed by either the cation exchange resin that is part of a typical cation conductivity monitor, or by the weak base anion exchange resin. By subtracting the value of conductivity due to carbon dioxide (at the outlet of the weak base anion exchange column) from the value of cation conductivity (at the outlet of the cation exchange column), the value of degassed cation conductivity is obtained. In the title of the invention, CWB conductivity is an abbreviation for cation—weak base conductivity. | 2012-07-12 |
20120178176 | COLOR CODED SWIPE FOR PORTABLE EXPLOSIVE OR DRUG DETECTION SYSTEM - A test swipe for testing drugs, explosives or a chemical compound includes a base; and one or more swipe pads positioned on the base to receive one or more chemicals thereon, the one or more swipe pads displaying an array of colors after receiving the chemicals to uniquely identify a chemical compound. | 2012-07-12 |
20120178177 | Biological Components Within the Cerebrospinal Fluid - The invention provides novel methods for isolating, characterizing, comparing, and using biological components that are present in the cerebrospinal fluid. Such biological structures, called CS-MPs, can be used for identifying biomarkers that reflect the status (or anticipate the development) of disorders of the Central nervous System (CNS). The novel methods, biological products, and related kits make possible the use of CS-MPs and of their components as biomarkers for the diagnosis, prognosis, or monitoring of CNS disorders. The CS-MPs have a diameter comprised between 100 and 1000 nm and contain phosphatidylserine (PS). | 2012-07-12 |