26th week of 2011 patent applcation highlights part 50 |
Patent application number | Title | Published |
20110159455 | SURGICAL GUIDE AND METHOD - A method for preparing a surgical guide for positioning of a dental implementation. The method includes positioning a positioning device relative to a model jawbone, translating the positioning device in a BL direction, adjusting a BL angle of the positioning device about a BL pivot axis corresponding to a desired position of a top of the dental implementation, and fixing the BL position, BL angle, and z-height of the positioning device. A mounting assembly mounts to the positioning device and includes a removable rotation block with a guide hole. The mounting assembly is movable in the MD direction while the BL position is fixed. A template fixes the mounting assembly for transferring the positioning information to a patient's mouth. Various aspects of the design process can be performed on a computer. The guide and a method of using the guide to perform an implant procedure are also disclosed. | 2011-06-30 |
20110159456 | Oral Care Suction Device With Suction Control Port Cover - An oral care suction device that includes a suction control port cover. The oral care suction device includes a body having a fluid flow passage formed therethrough. The body has a suctioning feature is located on or joined at its distal end. The body also has an attachment feature located at its proximal end. The oral care suction device also includes a suction control port located intermediate the distal end and proximal end of the body and configured to be covered by a finger or a portion of the hand of a user to alter the level of suction through the suctioning feature while allowing one hand operation of the suctioning device. The suction control port defines a channel from an exterior of the body to the fluid flow passage. A breathable fabric is positioned to cover the suction control port so that contact of the finger or portion of the hand of a user with liquids and particles drawn into and through the fluid flow passage during suctioning is minimized. | 2011-06-30 |
20110159457 | BLOOD ABSORBING DEVICE - The present invention proposes an apparatus ( | 2011-06-30 |
20110159458 | Endodontic Instrument With Modified Memory and Flexibility Properties and Method - Medical instruments, particularly, endodontic instruments with unique limited memory characteristics, and methods for making such instruments. One embodiment includes heat treating a finished endodontic instrument. A related embodiment includes electropolishing a finished endodontic instrument and then heat treating the endodontic instrument. | 2011-06-30 |
20110159459 | TOOTH EXTRACTION TOOL - A tooth extracting tool including an elongated handle and a pair of tooth engaging members extending out of one end of the handle and a pneumatic or hydraulic piston for tightly gripping the tooth to be extracted between the pair of tooth engaging members. The tool also includes a mechanism for subjecting the grasped tooth to linear oscillation at an opposite end of the handle and for limiting the back and forth linear movement of the tooth to between about plus or minus 5 mm. | 2011-06-30 |
20110159460 | SYSTEMS AND METHODS OF ANALYZING VIBRATIONS IMPARTED TO TISSUES AND TEETH - Systems and methods are disclosed for performing dental diagnostics by inducing vibrations in a first dental object using a vibratory transducer; picking up at a receiver vibrations transmitted by the vibratory transducers; capturing vibrations from an second dental object and comparing the captured vibrations against a database of known dental characteristics; and generating a dental diagnostic. | 2011-06-30 |
20110159461 | TOOTHBRUSH EMPLOYING ACOUSTIC WAVEGUIDE - A power toothbrush ( | 2011-06-30 |
20110159462 | THERAPEUTIC AGENT FOR PERIODONTAL DISEASES AND METHOD OF TREATING PERIODONTAL DISEASES - A therapeutic agent is provided for periodontal diseases by which a biofilm formed inside hard tissues in an oral cavity is removed and the hard tissues are re-calcified. The biofilm formed in a fine fracture within contaminated tooth hard tissues is chemically dissolved and removed and calcium ions contained in the biofilm are precipitated as a calcium salt under an alkali condition so that the anatomically present fine fracture is sealed by the precipitated salt. | 2011-06-30 |
20110159463 | DEVICE FOR TREATING HUMAN KERATINOUS MATERIAL - A method of making up human keratinous material, the method including: acquiring at a first location and storing a starting image and/or starting relief of keratinous material; and reproducing on keratinous material of the same type an image for reproduction and/or relief for reproduction corresponding to the starting image and/or relief, possibly after performing processing, the image and/or relief for reproduction being reproduced at a second location that is different from the first location. | 2011-06-30 |
20110159464 | SPHERICAL OBJECT PROVIDED WITH A MAP - A spherical object is disclosed provided with a map substantial covering its entire surface wherein the map represents only a portion of the Earth such as a town, city, district, county, state or country. A label is also disclosed provided comprising a series of biconvex shapes which collectively describe such a map. | 2011-06-30 |
20110159465 | Networked education and entertainment technology - This invention is intended to improve immersive simulation techniques. The integration of five components constitutes a new method creating an educational experience that will improve student levels of interest and performance in STEM and other subjects. The five components are:
| 2011-06-30 |
20110159466 | DOUBLE-FUNCTION PICTORIAL INSTRUCTION METHOD FOR CHINESE PHONETIC CURSIVE SYMBOL - A double-function pictorial instruction method for Chinese phonetic cursive symbol is an instruction system using transforming pattern of English alphabets to teach both the pronunciation and writing of Chinese phonetic symbol. Through transforming English alphabets into patterns similar to Chinese phonetic symbols, people capable of reading English will learn to read the Chinese phonetic symbols while seeing the symbols through the learning system. | 2011-06-30 |
20110159467 | EEG-BASED ACCELERATION OF SECOND LANGUAGE LEARNING - EEG-based acceleration of second language learning is accomplished by measuring via single-trial EEG a learner's cognitive response to the presentation (visual or auditory) of language learning materials and updating a user model of latent traits related to language-learning skills in accordance with the cognitive response. The user model is suitably updated with each trial, each trial being triggered by learner fixation on a portion of visual materials and/or a next phoneme in auditory materials. Additional discrimination may be achieved through the use of saccades or fixation duration features. | 2011-06-30 |
20110159468 | Process And Apparatus For Anger And Behavior Management - A method is performed to manage a secondary emotion such as anger, allowing the user to choose their behavior in response to the primary emotion thereby managing their behavior. The user turns on a figurine which plays back a message which invites the user to complete the process. The user names and records on a note the primary emotion being experienced. Then, the user claims this primary emotion as being responsible for the anger and records this on the note. Then, the user deposits this note into a figurine that disposes the note. This last step, by disposing the note, symbolically releases the anger, which helps the user manage anger and reminds the user of their power to choose their response to feelings of anger. The apparatus comprises a figurine containing, in one embodiment, a voice module to play back a message and a paper shredder to dispose the note. | 2011-06-30 |
20110159469 | MULTIMEDIA APPARATUS - A multimedia apparatus is provided. The multimedia apparatus extracts a workout prescription including at least one method of exercise based on user information inputted by a user. As a result, the user is able to set and manage his exercise method using the multimedia apparatus. | 2011-06-30 |
20110159470 | INTERACTIVE MEDICAL DIAGNOSTICS TRAINING SYSTEM - A medical diagnostics training system presents a sequence of interactive display images comprising a medical diagnostics case study (CS) to a student which includes challenges to which the student responds to qualify his/her competency in a diagnostics technique to be imparted by the case study (CS), collecting and processing the student responses to determine the competency in the diagnostics technique and providing a review of the response, and based thereon further providing directed feedback from a physician in the critical thinking in order to master the diagnostics technique where necessary. The system includes a computer processor for implementing system communication processes, interactive users interface processes, training workflow processes and medical diagnostics case study (CS) configuring processes and a database for receiving and storing data comprising the medical diagnostics case study (CS) and challenges, interactive display image data comprising and data comprising student responses to the challenges. | 2011-06-30 |
20110159471 | AUDIO/VIDEO TEACHING SYSTEM - An audio/video teaching system is connected with learning equipment via a network system to provide for skill evaluation in the learning process. The audio/video teaching system has an audio/video capturing apparatus for capturing audio/video exemplification of various skills and guiding analysis, an audio/video database for storing the audio/video exemplification and guiding analysis, a connection module for connecting with the network system to receive requests and instructions of a user, and a selection module for selecting the required exemplification and guiding analysis from the database, thereby providing a low-cost learning system with ease, convenience and flexibility as compared to prior techniques. | 2011-06-30 |
20110159472 | DELIVERY METHODS FOR REMOTE LEARNING SYSTEM COURSES - In general, the present disclosure includes delivery methods for remote learning system courses. In one embodiment, a method includes transmitting, to a remote learning management system, a request for a course associated with a course type. The remote learning management system is operable to provide a plurality of courses based on the request. Information associated with the course is transmitted to or received from the remote learning management system. The information included a delivery method. The course catalog is automatically updated based, at least in part, on the delivery method of the course. | 2011-06-30 |
20110159473 | ARRAY OF ELECTRICAL CONNECTORS HAVING OFFSET ELECTRICAL CONNECTORS - An array of electrical connectors is provided having a first plurality of electrical connectors configured to be mounted on a substrate, and a second plurality of electrical connectors configured to be mounted on the substrate at a location adjacent the first plurality of electrical connectors, such that the first plurality of electrical connectors is offset with respect to the second plurality of electrical connectors along an insertion direction. | 2011-06-30 |
20110159474 | SOLUTIONS FOR PERFUSING AND PRESERVING ORGANS AND TISSUES - The present invention relates to solutions which are suitable for the perfusion and preservation of organs, organ parts, tissues or tissue parts of human or animal origin. The solutions suitable for this contain at least one active agent, which is selected from the group of NO-independent stimulators and activators of soluble guanylate cyclase. The invention furthermore relates to methods for producing the solutions according to the invention, and to the use of the solutions in various types of medical procedures, particularly in the field of transplantation medicine. | 2011-06-30 |
20110159475 | INTEGRATED BIO-REACTOR MONITOR AND CONTROL SYSTEM - Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. The controller receives information related to a condition of the process over a first communication network, determines a control signal based on the received information and the programmed process, and sends the control signal over a second communication network to a benchtop utility tower. In one example, the utility tower can include transmitters for temperature, pH, and dissolved oxygen that send information related to a condition of the process to the controller over the first communication network, and an agitation system, a gas control system, a temperature control system and a pump control system that perform a control action based on the control signal affecting the process condition. The utility tower can include a computer with a human-machine interface that communicates with the controller over a third communication network. | 2011-06-30 |
20110159476 | METHODS AND APPARATUS FOR CHARACTERIZING POLYMERIC MIXTURES - The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can be repeated one or more times using different experimental measurements produced by various chemical and physical protocols, so that the remaining candidate solutions converge to describe the actual polymeric mixture under investigation. Once the composition of the complex polymeric mixture has been characterized, the information thus generated can be used to facilitate, for example, the manufacture of a bio-equivalent of the complex polymeric mixture. | 2011-06-30 |
20110159477 | PRODUCTS AND ANALYTICAL METHOD - The present invention describes product and analysis method for analysis of a substance, a virus, a bacteria or a cell which binds to carbohydrate structures. One or more carbohydrates, or carbohydrate derivatives, is bound to spherical or non-spherical polymer beads (for example microspheres or nanospheres). Formed carbohydrate-polymer beads or carbohydrate-polymer particles, can bind to with more or less specific affinity to the substance, bacteria, virus or cell which shall be detected. The carbohydrate beads is contacted with a sample containing the substance, bacteria, virus or cell (completely or partially isolated, or not purified, in a non-diluted or diluted solution). The resulting mixture is optionally added to a gel, or a column containing a gel, through which the resulting mixture (of carbohydrate beads or carbohydrate particles bound to the substance, virus, bacteria or cell), is allowed to migrate. Detection of aggregates is made visually or using apparatus for detection. | 2011-06-30 |
20110159478 | METHOD FOR SCREENING DRUG CANDIDATES BY USING DOMAIN PROTEIN - The present invention relates to a method for screening and discovering bioactive materials using specifically selected protein domains interacting with specific intracellular proteins, and more particularly, to (1) a screening method including confirmation of changes in biological activities by introducing a specific protein domain into microorganisms or animal and plant cells and (2) a screening method including confirmation of changes in biological activities after introducing the specific protein domains into a number of microorganisms or animal and plant cells. Via this method, according to the present invention, it is possible that the selected protein domains can be used to develop novel antibiotic agents with antimicrobial activity effective on bacteria resistant to conventional antibiotics while requiring less genetic information compared with a conventional drug which targets specific genes. | 2011-06-30 |
20110159479 | GENETIC POLYMORPHISMS IN THE CYTOCHROME P450 GENE WITH CLOPIDOGREL RESISTANCE - The present invention relates to a method for predicting the resistance of a human subject to clopidogrel, which comprises detecting the presence or absence of a A allele at position 636 of exon 4 in the CYP2C19 gene, wherein the presence of the A allele is indicative of a clopidogrel resistance. The present method may be very useful in predicting the resistance of a human subject to clopidogrel and contribute to more effective chemotherapy for patients having coronary artery disease and drug-eluting stent. | 2011-06-30 |
20110159480 | CELL-BASED SCREENING ASSAY TO IDENTIFY MOLECULES THAT STIMULATE IFN-ALPHA/BETA TARGET GENES - A method using cells transformed with a construct containing a reporter gene operatively-linked to an interferon stimulated response element for identifying an agent, such as a chemical compound, peptide or polypeptide, which exhibits an interferon-like activity on the interferon stimulated response element (ISRE) and modulates genes activated by activation of the ISRE. | 2011-06-30 |
20110159481 | Solid-phase chelators and electronic biosensors - Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and electronically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced. Additionally, devices and methods are provided for detecting biomolecules through the detection of pyrophosphate ions. | 2011-06-30 |
20110159482 | METHOD FOR DETECTING MULTIPLE SMALL NUCLEIC ACIDS - The present invention discloses a method for simultaneously detecting multiple small nucleic acids, which comprises steps: mixing a specimen, fluorescent probes, and bridge nucleic acids having different lengths to form a tested liquid; hybridizing the mixed short nucleic acid molecules, probes and bridge nucleic acids; adding ligases to enable the ligations of the short nucleic acid molecules and the fluorescent probes with the bridge nucleic acids being the templates; injecting the tested liquid into a capillary, and applying a voltage to the capillary to generate an electrophoresis effect and separate the hybridization products; and using laser to induce different fluorescent rays from different reaction products, and measuring the fluorescent rays, whereby the present invention can simultaneously detect multiple types of short nucleic acid molecules in a single capillary. | 2011-06-30 |
20110159483 | CYANINE COMPOUNDS, COMPOSITIONS INCLUDING THESE COMPOUNDS AND THEIR USE IN CELL ANALYSIS - A compound having the general formula I or a conjugate thereof, wherein various groups are as defined in the specification. A composition includes: (i) a compound having the general formula I or a conjugate thereof; and (ii) at least one surfactant selected from cationic surfactants and nonionic surfactants. Also disclosed is a preparation method for the composition and a kit comprising the composition. Further disclosed is a method for identifying and differentiating erythroblasts, basophils and lymphocytes simultaneously using the composition according to the present disclosure. | 2011-06-30 |
20110159484 | APPARATUS AND METHOD OF AUTHENTICATING PRODUCT USING POLYNUCLEOTIDES - A method of authenticating a product includes; hybridizing a target polynucleotide which is associated with the product and which includes a first target region and a second target region adjacent to the first target region with a probe polynucleotide that comprises a first segment having a nucleotide sequence completely complementary to the first target region and a second segment having a nucleotide sequence completely complementary to the second target region, ligating one end of the first segment of the probe polynucleotide to one end of the second segment of the probe polynucleotide, amplifying the probe polynucleotide and detecting the amplified polynucleotide. | 2011-06-30 |
20110159485 | Lysis Buffers for Extracting Nucleic Acids - The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material. | 2011-06-30 |
20110159486 | CELL CYCLE SWITCH 52(CCS52) AND METHODS FOR INCREASING YIELD - Methods and compositions for modulating plant yield are provided. Methods include employing cell cycle switch 52 (ccs52). The ccs52 sequences are used in a variety of methods including modulating plant biomass, growth, or both. Transformed plants, plant cell, tissues, seed, and expression vectors are also provided. | 2011-06-30 |
20110159487 | Identification of a Gene Expression Profile that Differentiates Ischemic and Nonischemic Cardiomyopathy - A method of preparing a gene expression prediction profile for distinguishing ischemic and nonischemic cardiomyopathy comprises the steps of obtaining clinical specimens from patients suffering from ischemic or nonischemic cardiomyopathy, isolating nucleic acid sequences from at least a plurality of said specimens, obtaining a gene expression level corresponding to each individual of said nucleic acid sequence by a gene expression profiling method, identifying genes having differences in gene expression by comparing the gene expression level of an ischemic specimen with the gene expression level of a nonischemic specimen, and identifying a gene expression prediction profile comprises genes identified as having differences in gene expression so that said prediction profile distinguishes ischemic and nonischemic cardiomyopathy. | 2011-06-30 |
20110159488 | Primers for Amplification and Sequencing of Eubacterial 16S rDNA for Identification - The invention relates to oligonucleotides for the qualitative and/or quantitative amplification and/or the sequencing of 16S rDNA-genes, as well as of fragments thereof and RNA derived thereof. It relates to their use as primers in amplification reactions and in sequencing, in particular in combination for the identification of the genus/species/strain of the bacterial sample or clinical isolate. | 2011-06-30 |
20110159489 | SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH DIETARY WEIGHT LOSS - The present invention relates to genetic polymorphisms associated with obesity and obesity-related phenotypes and their use in predicting if an individual successfully completes a dietary weight loss intervention program. | 2011-06-30 |
20110159490 | USE OF THE COMBING PROCESS FOR THE IDENTIFICATION OF DNA ORIGINS OF REPLICATION - Eukaryotic genomes are duplicated by the activation of multiple bidirectional origins of replication. The replication programs of these cells depend on the temporal and spatial organisation of replication origins throughout the genome. To investigate the replication program in a higher eukaryote, we employed a technique called molecular combing. This technique allows for a quantitative analysis of DNA replication on a genome wide basis. As a model system, | 2011-06-30 |
20110159491 | Method for detecting cytosine methylation in DNA samples - Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting differently, and the pretreated DNA is subsequently amplified using a polymerase and at least one primer. In the next step, the amplified genomic DNA is hybridized to at least one oligonucleotide, forming a duplex, and said oligonucleotide is elongated by at least one nucleotide, the nucleotide carrying a detectable label, and the elongation depending on the methylation status of the specific cytosine in the genomic DNA sample. In the next step, the elongated oligonucleotides are analyzed for the presence of the label. | 2011-06-30 |
20110159492 | Diffuse Large B-Cell Lymphoma Markers and Uses Therefore - The present invention provides methods and compositions for prognosing treatment outcome in DLBCL patients, diagnosing DLBCL and monitoring efficacy of DLBCL treatment. | 2011-06-30 |
20110159493 | DIAGNOSTIC POLYMORPHISMS FOR CARDIAC DISEASE - One or more polymorphisms, including single nucleotide polymorphisms (SNPs), or combinations thereof, for diagnosis of cardiac disease, such as heart failure and atrial fibrillation. | 2011-06-30 |
20110159494 | Analyzing the FMR1 Gene - A method of predicting a degree of risk of autoimmunity in a human female is disclosed. The method may include analyzing the female's FMR1 gene, wherein the FMR1 gene has a first allele and a second allele, determining the number of triple CGG repeats on each of the first and second alleles; defining a normal range of triple CGG repeats; and comparing the number of triple CGG repeats on each of the first and second alleles to the normal range. If the triple CGG repeat number for one of the first and second alleles is in the normal range and the triple CGG repeat number for the other one of the first and second alleles is less than the lower boundary of the normal range, then the female is at increased risk of autoimmunity. Additionally, a method of predicting pregnancy chances for a human female is disclosed. The method may include analyzing the female's FMR1 gene, wherein the FMR1 gene has a first allele and a second allele; determining the number of triple CGG repeats on each of the first and second alleles; defining a normal range of triple CGG repeats; and comparing the number of triple CGG repeats on each of the first and second alleles to the normal range. If the triple CGG repeat number for one of the first and second alleles is in the normal range and the triple CGG repeat number for the other one of the first and second alleles is less than the lower boundary of the normal range, then the female has decreased chances of pregnancy. | 2011-06-30 |
20110159495 | METHOD FOR THE QUANTITATIVE DETECTION OF AN ORGANIC SUBSTANCE IN A SAMPLE - A method for the quantitative detection of an organic substance containing a nucleic acid to be detected in a sample based on a given threshold value for that organic substance in the sample, the use of this method, as well as a kit for practicing this method. | 2011-06-30 |
20110159496 | MOLECULAR DIAGNOSIS AND CLASSIFICATION OF MALIGNANT MELANOMA - The present invention provides methods for diagnosing and providing a prognosis of melanoma using molecular markers that are overexpressed in melanoma cells. The invention provides kits for diagnosis and prognosis. Also provided are methods to identify compounds that are useful for the treatment or prevention of melanoma and melanoma progression. | 2011-06-30 |
20110159497 | FREEZE-DRIED COMPOSITIONS FOR CARRYING OUT PCR AND OTHER BIOCHEMICAL REACTIONS - A composition for carrying out a chemical or biochemical reaction, said composition being in a freeze-dried form and comprising (i) a set of reagents comprising at least some of the chemical or biochemical reagents necessary for conducting said chemical or biochemical reaction, (ii) a glass forming agent, (iii) a stabilising agent therefore and (iv) fish gelatine. In particular compositions for carrying out PCR are foreseen. Kits comprising these compositions and methods for using them form a further aspect of the invention. | 2011-06-30 |
20110159498 | METHODS, AGENTS AND KITS FOR THE DETECTION OF CANCER - The present invention relates to methods of diagnosing a cancer in a subject, and methods of providing a prognosis for a subject that has a cancer. The invention also relates to diagnostic and prognostic kits for cancer. | 2011-06-30 |
20110159499 | METHODS AND COMPOSITIONS FOR DETECTING GENETIC MATERIAL - This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques for allowing detection of small, but statistically significant, differences in polynucleotide copy number. | 2011-06-30 |
20110159500 | COMPOSITIONS INCLUDING GINGER FOR THE AMELIORATION OR PREVENTION OF INFLAMMATORY CONDITIONS - The invention encompasses a method for diagnosing an arthritic condition and a gastrointestinal inflammatory disorder in a companion animal. The invention also encompasses a method for identifying ingredients for a pet food composition that are suitable for preventing, ameliorating the symptoms of, or treating an arthritic condition or gastrointestinal inflammatory disorder. | 2011-06-30 |
20110159501 | USE OF METHYLATED OR UNMETHYLATED LINE-1 DNA AS A CANCER MARKER - The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression and treatment. | 2011-06-30 |
20110159502 | USE OF METHYLATED OR UNMETHYLATED LINE-1 DNA AS A CANCER MARKER - The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression and treatment. | 2011-06-30 |
20110159503 | DNA EXTRACTION METHOD FOR BURSAPHELENCHUS XYLOPHILUS FROM WOOD CHIPS, LAMP PRIMER SET FOR BURSAPHELENCHUS XYLOPHILUS, AND DETECTION METHOD FOR BURSAPHELENCHUS XYLOPHILUS FROM WOOD CHIPS - To extract and detect | 2011-06-30 |
20110159504 | METHYLATION MARKERS FOR SENSITIVITY TO MICROTUBE BASED THERAPIES AND METHODS OF USE - The present invention relates to the use of nucleic acid methylation and methylation profiles to detect predict sensitivity of cells to cytotoxic chemotherapies, and in particular to microtubule based therapies, for example taxanes. The invention relates to methods for identifying a methylation profile of the checkpoint with forkhead and ring finger domains gene (CHFR) that is associated with a sensitivity to agents directed at the microtubule. | 2011-06-30 |
20110159505 | Method of Manufacturing a Mixture of Amplified Double-Stranded Nucleic Acids Comprising Unknown Sequence - The purpose of the subject invention is to provide a method of manufacturing a mixture of amplified double-stranded nucleic acids comprising unknown sequence including the complete 5′ end sequence, | 2011-06-30 |
20110159506 | METHODS FOR ASSESSING RNA PATTERNS - Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs. | 2011-06-30 |
20110159507 | METHOD FOR DETECTING THE DRUG EFFECTS OF DNA METHYLATION-INHIBITORS - Disclosed is a method for detecting the drug effects of DNA methylation inhibitors that detects the drug sensitivity of gene-expressing cells to DNA methylation inhibitors based on gene expression of a transcription factor (PU. 1) and/or gene expression of metallothionein (MT) that participates in differentiation to neutrophil and monocyte lines or based on DNA methylation in the metallothionein (MT) gene promotor region. Hematopoietic tumors can be treated effectively and specifically after predicting the effects of DNA methylation inhibitors on the hematopoietic tumor cells of myelodysplastic syndrome, acute myelocytic leukemia (AML), and other hematopoietic organ diseases, so therapeutic results are improved. | 2011-06-30 |
20110159508 | GFATS as Modifiers of the P53 Pathway and Methods of Use - Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided. | 2011-06-30 |
20110159509 | USE OF RUNX3 AND MIR-532-5P AS CANCER MARKERS AND THERAPEUTIC TARGETS - The invention relates to methods for cancer diagnosis, prognosis, and treatment based on the expression or activity levels of RUNX3 and miR-532-5p. Also disclosed is a method of reducing the inhibition of RUNX3 by miR-532-5p with an agent that interferes with the interaction between RUNX3 and miR-532-5p transcripts. | 2011-06-30 |
20110159510 | USE OF METHYLATED OR UNMETHYLATED LINE-1 DNA AS A CANCER MARKER - The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression and treatment. | 2011-06-30 |
20110159511 | Microfluidic Device Screening Method - The invention provides methods of screening a microbial host cell for a property of interest in a microfluidic device, the method comprising the steps of: a) transforming a d-alanine racemase-deficient microbial host cell with a polynucleotide construct comprising: i) one or more polynucleotide region providing the property of interest when present in the host cell, and ii) at least one polynucleotide region complementing the d-alanine racemase deficiency when present in the host cell; and b) screening the transformed host cell for the property of interest in the microfluidic device in the absence of externally provided d-alanine. | 2011-06-30 |
20110159512 | POLYNUCLEOTIDE SEQUENCES OF CANDIDA DUBLINIENSIS AND PROBES FOR DETECTION - The present invention relates to identification of centromeric sequences of | 2011-06-30 |
20110159513 | METHODS AND SYSTEMS FOR PREDICTING RESPONSE OF CELLS TO A THERAPEUTIC AGENT - The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided. | 2011-06-30 |
20110159514 | BIOMARKER FOR OSTEOARTHRITIS AND/OR OTHER AGEING-RELATED DISEASES, AND USE THEREOF - The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applications in the diagnosis of osteoarthritis and/or other ageing-related diseases, in determining the prognosis for an individual diagnosed with osteoarthritis and/or other ageing-related diseases, and in monitoring the efficacy of treatment for osteoarthritis and/or other ageing-related diseases. | 2011-06-30 |
20110159515 | COMPOSITIONS AND METHODS FOR THE RAPID GROWTH AND DETECTION OF MICROORGANISMS - The invention relates to assay methods for use in detecting specific materials such as core oligosaccharides derived from microorganisms, particularly pathogenic microorganisms, in a test sample. The invention further relates to compositions and methods for the rapid growth of such microorganisms enabling detection of same significantly earlier than is currently possible. In particular embodiments the invention is directed towards the rapid growth and/or detection of | 2011-06-30 |
20110159516 | PCan065 Antibody Compositions and Methods of Use - The invention provides isolated anti-PCan065 antibodies that bind to PCan065. The invention also encompasses compositions comprising an anti-PCan065 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PCan065 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PCan065 antibodies. The invention encompasses a method of producing the anti-PCan065 antibodies. Other aspects of the invention are a method of killing an PCan065-expressing cancer cell, comprising contacting the cancer cell with an anti-PCan065 antibody and a method of alleviating or treating an PCan065-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PCan065 antibody to the mammal. | 2011-06-30 |
20110159517 | Zinc binding compounds and their method of use - The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of zinc ions in a sample. The metal chelating moiety of the zinc-binding compound is an analog of the well-known calcium chelator, BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid), wherein the chelating moiety has been modified from a tetraacetic acid moiety to a tri- di- or monoacetic moiety. This change in acetic acid groups on the metal chelating moiety results in the selective bindings of zinc ions in the presence of calcium ions, both of which are present in biological fluids and intracellular cytosolic fluid and organelles. | 2011-06-30 |
20110159518 | METHOD FOR THE DIAGNOSIS OF THE PRESENCE OF AN OVARIAN CANCER - The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention. | 2011-06-30 |
20110159519 | OPTICAL BIOSENSORS - Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell. The biosensors may provide a signal when the biosensor is targeted and/or in response to a property of the cell or organism such as membrane potential, ion concentration or enzyme activity. | 2011-06-30 |
20110159520 | HYBRID PROTEINS COMPRISING MEMBRANE RECEPTOR AND ION CHANNEL, AND THEIR USE AS BIOSENSORS - The present invention relates to the use of a hybrid protein including the sequence of a first membrane receptor fused at its C-terminus to the N-terminus of an ion channel, and possibly containing a linker between the C-terminus of the first membrane receptor and the N-terminus part of the ion channel, the linker being absent in the natural configuration of the first membrane receptor and the ion channel, as a biosensor for: the screening of drugs modulating the activity of the first membrane receptor in its natural configuration, and/or for the in vitro diagnosis of pathologies associated with the presence or the variation of amount of a molecule modifying the activity of the first membrane receptor in its natural configuration. | 2011-06-30 |
20110159521 | METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME - The invention provides an ELISA assay for the determination of serum mast cell β-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the detecting antibody. Luminescent substrate CPSD was used to enhance the assay sensitivity. Also provided are methods for aiding in the diagnosis of irritable bowel syndrome by detecting the serum level of β-tryptase, histamine and/or prostaglandin E | 2011-06-30 |
20110159522 | Three-Dimensional Microfluidic Platforms and Methods of Use Thereof - Provided are methods and devices for formation and study of three-dimensional biological systems, including prokaryotic and eukaryotic cell migration, proliferation, and differentiation. | 2011-06-30 |
20110159523 | N-TERMINAL SPECIFIC CHEMICAL LABELING FOR PROTEOMICS APPLICATIONS - Described herein is a method that may be used in various applications, such as drug development, medical diognosis and gene/protein therapy. In one embodiment, the subject matter discloses an effective method for identification and quantification of large sets of proteins/peptides in vitro and cells in vivo. | 2011-06-30 |
20110159524 | METHOD FOR MONITORING HYDROLYTIC ACTIVITY - The present invention relates to methods of measuring the activity of a hydrolytic agent comprising contacting a biomolecule with a hydrolytic agent in the presence of a fluorescent dye under conditions that allow digestion of the biomolecule by the hydrolytic agent. The fluorescence of the dye is monitored over time and a change in fluorescence signifies digestion of the biomolecule by the hydrolytic agent. The biomolecule is preferably a protein, peptide or proteome but can also be a carbohydrate, oligonucleotide or lipid. Further methods relate to determining an end point for digestion of a biomolecule by a hydrolytic agent, and methods of monitoring digestion of a biomolecule by a hydrolytic agent. The monitoring can be performed on the reaction mixture in real time or via sampling. The invention also relates to kits for carrying out the method. | 2011-06-30 |
20110159525 | METHODS TO DETERMINE IMMUNOGENICITY OF HUMANIZED ANTI-TAG 72 CC49 ANTIBODIES - The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody includes a non-conservative amino acid substitution in a light chain complementarity determining region 3 of the CC49 antibody. In a further embodiment, the humanized CC49 antibody includes a non-conservative substitution of a first residue in a light chain complementarity determining region 3 and a substitution of a second residue in a complementarity determining region of the humanized CC49 antibody. In several of the embodiments, methods are disclosed for the use of a humanized CC49 antibody. | 2011-06-30 |
20110159526 | METHODS FOR PRDICTING PREGNANCY OUTCOME IN A SUBJECT BY HCG ASSAY - The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample. | 2011-06-30 |
20110159527 | METHODS AND KITS FOR DIAGNOSING NEURODEGENERATIVE DISEASE - Methods and diagnostic kits for determining whether a subject may develop a or for diagnosing a neurodegenerative disease. The method includes quantitating the amount of alpha-synuclein and total protein in a cerebrospinal fluid (CSF) sample obtained from the subject and calculating a ratio of alpha-synuclein to total protein content; comparing the ratio of alpha-synuclein to total protein content in the CSF sample with the alpha-synuclein to total protein content ratio in CSF samples obtained from healthy neurodegenerative disease-free subjects; and (c) determining from the comparison whether the subject has a likelihood to develop neurodegenerative disease or making a diagnosis of neurodegenerative disease in a subject. A difference in the ratio of alpha-synuclein to total protein content indicates that the subject has a likelihood to develop a neurodegenerative disease or has developed a neurodegenerative disease. | 2011-06-30 |
20110159528 | Methods and Materials for the Detection of Leishmania Infection - The present invention provides rapid diagnostic assays for the detection of | 2011-06-30 |
20110159529 | FUSION PROTEIN HAVING LUMINESCENCE ACTIVITY - The fusion protein comprising (1) a first region comprising the amino acid sequence of SEQ ID NO: 18 and (2) a second region comprising an amino acid sequence for a polypeptide containing at least one cysteine residue for binding to other useful compound via the thiol group can be modified by chemical modification, and thus has a high catalytic ability for a luminescence activity and is highly available for general purposes. | 2011-06-30 |
20110159530 | METHODS OF QUANTIFYING BIOMARKERS - Methods are provided for simultaneously measuring hematocrit (hct) level and the concentration of a biomarker in a blood specimen. Thus, serum biomarker concentrations can be more accurately measured. The methods are particularly useful for newborn screening programs. | 2011-06-30 |
20110159531 | METHOD AND APPARATUS FOR MEASURING AMOUNT OF SUBSTANCE - Disclosed herein are a method and apparatus for measuring an enzyme amount. The measurement of the enzyme amount is carried out by measuring a transmittance of a reaction mixture containing the enzyme and its substrate over the reaction time period and providing an optical characteristic curve, dividing the optical characteristic curve by a uniform distance in a reaction time axis direction to set a plurality of sections, and selecting one section satisfying preset linear conditions and having a maximum gradient absolute value from the plurality of sections and calculating an enzyme amount from the gradient of the optical characteristic curve in the selected section. | 2011-06-30 |
20110159532 | GEF-H1b: BIOMARKERS, COMPLEXES, ASSAYS AND THERAPEUTIC USES THEREOF - The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S. | 2011-06-30 |
20110159533 | BIOPARTICLE CAPTURE DEVICE, AND USE THEREOF - A device for capturing suspended bioparticles in a liquid medium, includes:
| 2011-06-30 |
20110159534 | METHOD AND CULTURE MEDIUM FOR ENHANCED DETECTION OF MYCOBACTERIUM - The present invention relates to an improved culture medium and method for the enhanced growth and detection of | 2011-06-30 |
20110159535 | PREPARATION AND USE OF NUCLEATED RED BLOOD CELL SIMULATING PARTICLES AND HEMATOLOGY CONTROL MIXTURES - The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product. The present disclosure also provides a hematology control mixture containing the nucleated red blood cell simulating particles. In addition, the present disclosure describes the use of the nucleated red blood cell simulating particles and the hematology control mixtures comprising the same, for the quality control of a blood cell analyzer. | 2011-06-30 |
20110159536 | DEVICE FOR CAPTURING OBJECT AND METHOD FOR USING THE SAME - An object of the present invention is to provide an object-capturing device which accurately detects objects such as microorganisms captured at a test site. The object-capturing device of the present invention includes a capturing dish holding a carrier, which captures objects (microorganisms), on a first side of the capturing dish. The capturing dish has a through hole extending from the first side to a second side of the capturing dish. The object-capturing device is used in a way such that, after the objects are captured with the carrier directed upward, the carrier is directed downward and reagents for detecting the objects are contacted with the objects captured on the carrier through the through hole. | 2011-06-30 |
20110159537 | SYNTHETIC PATHWAY ENZYMES FOR THE PRODUCTION OF ARGYRINS - The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro-organisms containing nucleic acid sequences encoding the synthetic pathway enzymes for the production of Argyrins, e.g. for inserting one or more of these coding sequences, mutating in a targeted manner one or more of these nucleic acid sequences, in a wild type producer micro-organism or in a heterologous micro-organism, for the production of Argyrins. | 2011-06-30 |
20110159538 | Process for Preparation of Insulin Compounds - The present invention relates to the preparation of insulin compounds including their analogs or derivatives thereof from their corresponding precursor forms by a one step enzymatic reaction involving the combinatorial and concurrent use of optimal quantities of trypsin and carboxypeptidase B that work synergistically directing the reaction in a controlled manner to avoid production of random undesired byproducts. Particularly, the enzymatic conversion reactions of the instant invention offer advantages of reduction in the number operational steps, higher yield and purity of the desired end products. | 2011-06-30 |
20110159539 | METHOD FOR PRODUCING RECOMBINANT PROTEINS WITH A CONSTANT CONTENT OF PCO2 IN THE MEDIUM - A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO | 2011-06-30 |
20110159540 | Methods for Chemically Synthesizing Immunoglobulin Chimeric Proteins - The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule. | 2011-06-30 |
20110159541 | Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression - Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. | 2011-06-30 |
20110159542 | IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS - The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided. | 2011-06-30 |
20110159543 | SCALABLE PROCESS FOR CULTURING PER.C6 CELLS AND PRODUCING PRODUCTS THEREFROM - The invention provides methods for culturing adherent PER.C6 cells and producing products therefrom. | 2011-06-30 |
20110159544 | Method for treating cellulosic material and CBHII/CEL6A enzymes useful therein - The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used, for example for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology are described, as well as uses of the enzymes and enzyme preparations. | 2011-06-30 |
20110159545 | Fungamyl-like Alpha-Amylase Variants - The invention relates to a variant of a parent Fungamyl-like fungal alpha-amylase, which exhibits improved thermal stability at acidic pH suitable for, e.g., starch processes. | 2011-06-30 |
20110159546 | PROCESS FOR THE CO-PRODUCTION OF CHITIN, ITS DERIVATIVES AND POLYMERS CONTAINING GLUCOSE, MANNOSE AND/OR GALACTOSE, BY THE FERMENTATION OF THE YEAST PICHIA PASTORIS - The presently disclosed subject matter concerns a process for the co-production of glucosamine polymers (chitin, chitosan or any of its derivatives) and polymers containing glucose, mannose and/or galactose, by the high cell density fermentation of the yeast | 2011-06-30 |
20110159547 | POLYMERASE CHAIN REACTON METHOD, POLYMERASE CHAIN REACTON DROPLET DEVICE, AND POLYMERASE CHAIN REACTON DROPLET DEVICE ARRAY - The present invention discloses a polymerase chain reaction (PCR) method, a PCR droplet device and a PCR droplet device array. The steps of the method comprise that a liquid comprising an analyzer is dropped on the heating coil disposed on the droplet device to form a droplet, then dropping a hydrophobic solution to prevent the droplet from evaporating. When an electric current or a voltage is supplied through at least one conducting wire to heat the heating coil, the inside of the droplet can generate buoyancy to drive the analyzer to move to the top of the inside of the droplet. Subsequently, the analyzer is moved to a periphery of the inside of the droplet so as to form a thermal cycle. Therefore the template is amplified by recycling the thermal cycle. | 2011-06-30 |
20110159548 | METHOD FOR AMPLIFYING MONOMORPHIC-TAILED NUCLEIC ACIDS - The present teachings provide methods for amplifying a plurality of target nucleic acids. In some embodiments, a first oligo-dT-universal primer comprising a 3′ oligo-dT portion and a first 5′ universal portion is used to reverse transcribe a plurality of 3′ poly-A tail-containing nucleic acids. A poly-A tail is added to the 3′ end of the first strand products to form a two-tailed reaction product. The two-tailed reaction product is amplified in a PCR, wherein the PCR comprises the first oligo-dT-universal primer, and a second oligo-dT-universal primer, wherein the second oligo-dT-universal primer comprises a 3′ oligo-dT portion and a second 5′ universal portion, wherein the second 5′ universal portion of the second oligo-dT-universal primer comprises a different sequence than the first 5′ universal portion of the first oligo-dT-universal primer. The present teachings also provide compositions and kits for amplifying target nucleic acids containing monomorphic tails. | 2011-06-30 |
20110159549 | Temperature control for light-emitting diode stabilization - A system is provided that includes a light-emitting diode (LED); a temperature sensor in thermal contact with the LED and capable of measuring an operating temperature and generating an operating temperature signal; and a temperature regulating system capable of receiving the operating temperature signal and regulating the operating temperature based on the operating temperature signal. A method for stabilizing the temperature of an LED is provided. A method is provided that includes providing a system comprising an LED, a reaction region, and a sample in the reaction region; generating excitation beams with the LED; directing excitation beams to the sample; detecting an optical property of the sample to obtain detection data; measuring the- operating temperature of the light emitting diode; and adjusting the detection data of an excitation beam characteristic shift related to the operating temperature, when the LED is operated at the operating temperature to generate the excitation beams. | 2011-06-30 |
20110159550 | RNA ISOLATION FROM SOLUBLE URINE FRACTIONS - The invention provides methods for isolating RNA from the soluble fraction of urine. The methods can be used for detecting the presence or absence of an RNA, or quantifying the amount of an RNA. The methods are useful for diagnosing an individual suspected of having a disease by detecting the level of RNA associated with the disease in the soluble fraction of urine. The methods are also useful for prognosing an individual diagnosed with a disease by detecting the level of RNA associated with the disease in the soluble fraction of urine. | 2011-06-30 |
20110159551 | cDNA SYNTHESIS USING A REVERSIBLY INACTIVATED REVERSE TRANSCRIPTASE - The present invention provides compositions and methods for a reverse transcription reaction using a reversibly inactivated reverse transcriptase enzyme. The reversibly inactivated reverse transcriptase enzyme results from a chemical modification which inactivates the reverse transcriptase enzyme. The activity of the reverse transcriptase enzyme is recovered by an incubation of the reaction mixture at elevated temperature prior to, or as part of the reverse transcription reaction. The reverse transcriptase enzyme of the present invention provides for a signficant reduction in non-specific reverse transcription from template nucleic acid molecules because the formulation of the reaction mixture does not support the formation of reverse transcription products prior to activation of the reverse transcriptase. | 2011-06-30 |
20110159552 | LACTIC ACID BACTERIA-DERIVED DOUBLE-STRANDED RNA - It is intended to provide an immunomodulator, which has a high safety and can be effectively incorporated into cells, and a method of producing the same. A double-stranded RNA originating in a lactic acid bacterium; an immunomodulator comprising the double-stranded RNA originating in a lactic acid bacterium as the active ingredient; and a method of producing the double-stranded RNA originating in a lactic acid bacterium. Lactic acid bacterial cells belonging to the genus | 2011-06-30 |
20110159553 | Methods for Detection of Micro RNA Molecules - Methods and kits are provided for the production and use in microarray assays of labeled miRNA molecules and labeled cDNA molecules complementary to miRNA molecules. | 2011-06-30 |
20110159554 | YEAST FOR PRODUCTION OF GLUCOSE, AND METHOD FOR PRODUCTION OF GLUCOSE USING THE SAME - The invention provides: yeast having cellulose degradation ability that degrades cellulose outside the cell and glucose accumulation ability that accumulates, in a reaction liquid, glucose produced from cellulose as a result of the cellulose degradation ability, when the yeast was brought into contact with cellulose in the reaction liquid; and a method for producing glucose, wherein the glucose is produced from cellulose, the method comprising the step of bringing the yeast into contact with cellulose in a reaction liquid and the step of separating and collecting, from the reaction liquid, glucose accumulated in the reaction liquid as a result of the contact of the yeast with the cellulose. | 2011-06-30 |