26th week of 2009 patent applcation highlights part 44 |
Patent application number | Title | Published |
20090162791 | ELECTRONIC DEVICE AND METHOD OF MANUFACTURING THEREOF - The device has a carrier and an electric element. The carrier has a first and an opposed side and is provided with an connection layer, an intermediate layer and contact pads. The element is present at the first side and coupled to the connection layer. It is at least partially encapsulated by an encapsulation that extends into isolation areas between patterns in the intermediate layer. A protective layer is present at the second side of the carrier, which covers an interface between the contact pads and the intermediate layer. | 2009-06-25 |
20090162792 | METHOD FOR MANUFACTURING A SEMICONDUCTOR DEVICE - A spacer is formed on side and top portions of a photoresist pattern after a mask process is performed so that the spacer may be used as an etching mask. The spacer is formed using a polymer deposition layer which is a low temperature oxide or nitride that can be deposited on side and top portions of the photoresist pattern at 75˜220° C. after the mask process is performed. A method for manufacturing a semiconductor device includes forming a bottom anti-reflection coating film on an etch-target layer, patterning a photoresist layer formed on the bottom anti-reflection coating film, forming an insulation layer on a patterned photoresist layer and the bottom anti-reflection coating film, etching back the insulation layer to form a spacer on sidewalls of the patterned photoresist layer, and etching the bottom anti-reflection coating film and the etching target layer exposed by the spacer to form a fine pattern. | 2009-06-25 |
20090162793 | Method of Manufacturing Metal Interconnection of Semiconductor Device - Provided is a method of manufacturing a metal interconnection of a semiconductor device. According to the method, a first dielectric is formed on a semiconductor substrate having a device thereon, and a second dielectric and a metal layer pattern are formed on the first dielectric. Then, a first polymer pattern surrounding a photoresist pattern is formed on the second dielectric, and a via hole is formed in the second dielectric by etching using the first polymer pattern as a mask. The photoresist pattern and the polymer pattern are removed, and a contact is formed by filling the via hole. | 2009-06-25 |
20090162794 | METHOD FOR FABRICATING SEMICONDUCTOR DEVICE - A method for fabricating a semiconductor device is provided. The method includes forming an even number of first hard mask patterns over an etch target layer, forming sacrificial patterns on sidewalls of the first hard mask patterns and forming second hard mask patterns on sidewalls of the sacrificial patterns. The second hard mask patterns are formed to have a first space between the first hard mask patterns. The etch target layer is etched by using the first and the second hard mask patterns. | 2009-06-25 |
20090162795 | METHOD FOR MANUFACTURING A SEMICONDUCTOR DEVICE - A method for manufacturing a semiconductor device includes forming an etch-target layer over a semiconductor substrate having a lower structure, forming a first mask pattern over the etch-target layer, forming a spacer material layer with a uniform thickness over the etch-target layer including the first mask pattern, forming a second mask pattern on an indented region of the space material layer, and etching the etch-target layer with the first mask pattern and the second mask pattern as an etch mask to form a fine pattern. | 2009-06-25 |
20090162796 | METHODS OF FORMING A PATTERN OF A SEMICONDUCTOR DEVICE - In polymers for an anti-reflective coating, compositions for an anti-reflective coating and methods of forming a pattern of a semiconductor device using the same, the compositions for an anti-reflective coating include a polymer that includes a first repeating unit having a basic side group, a second repeating unit having a light-absorbing group, and a third repeating unit having a cross-linkable group; a photoacid generator; a cross-linking agent; and a solvent. The polymer for the anti-reflective coating, which may have a basic side group chemically bound to a backbone of the polymer, may properly adjust diffusion of an acid in an anti-reflective coating layer to improve the profile of a pattern. | 2009-06-25 |
20090162797 | METHOD OF MANUFACTURING LIQUID EJECTION HEAD - A method of manufacturing a liquid ejection head includes a step of forming a layer of a positive-type photosensitive resin on a substrate; a step of forming a pattern, used to form a liquid channel, by exposing the positive-type photosensitive resin layer to light; a step of forming a photosensitive layer, used to form a discharge port-forming member, on the pattern; and a step of forming a discharge port in such a manner that the photosensitive layer is patterned by exposing the photosensitive layer to i-line. The pattern has a predetermined absorbance for i-line and contains a specific compound. | 2009-06-25 |
20090162798 | Method of manufacturing master plate, method of manufacturing microneedle patch and apparatus exposure apparatus - A method of manufacturing a master plate includes the steps of forming a photoresist film on a substrate, disposing a photomask having a plurality of island radiation shields on the photoresist film followed by integrating the photomask and the photoresist film, applying light from a light source to the photoresist film through the photomask for selectively exposing the photoresist film, and developing the photoresist film to form a master plate, in which the method includes irradiating the photoresist film with the light from plural directions through the photomask to selectively expose the photoresist film from the respective directions. | 2009-06-25 |
20090162799 | METHOD AND SYSTEM FOR FABRICATING THREE-DIMENSIONAL STRUCTURES WITH SUB-MICRON AND MICRON FEATURES - A method and system are provided for fabricating three-dimensional (3D) structures having micron or submicron features. The method includes providing a continuously-formed relief structured material, the relief structured material having a first layer comprising a material having a pattern of relief structures formed on a first surface thereof. The structured material includes second layer comprising a photosensitive material that is disposed on the first layer. The relief structured material is exposed to radiation through the first layer, where the pattern of relief structures formed on the first surface of the first layer generates a 3-dimensional light intensity pattern of the radiation that is incident on the second layer. The exposed material is developed, where the developed material comprises a plurality of 3D structures having micron or submicron features. | 2009-06-25 |
20090162800 | Process for Imaging a Photoresist Coated over an Antireflective Coating - The process of the present invention relates to imaging a photoresist film coated over an antireflective coating film comprising a) forming an antireflective coating film from an antireflective coating composition, where the composition comprises a siloxane polymer, b) treating the antireflective film with an aqueous alkaline treating solution, c) rinsing the antireflective film treated with an aqueous rinsing solution, d) forming a coating of a photoresist over the film of the antireflective coating composition, e) imagewise exposing the photoresist film, and, f) developing the photoresist with an aqueous alkaline developing solution. | 2009-06-25 |
20090162801 | DEVICE AND METHOD FOR A GAS BURNER - A gas range having a cook top and a gas burner assembly connected to a source of gas having a variable flow rate. The burner assembly is positioned in the cook top. The gas burner assembly has a burner body with a gas input, the gas input is in a first flow communication with a first chamber and a second flow communication with a second chamber. Each chamber has at least one port in an exterior wall for flow communication to an area external of the burner body for combustion of the gas. The second flow communication has a tripping pin to deflect flow during high flow conditions and to not deflect flow during low flow conditions. A burner cap is positioned on the burner body. | 2009-06-25 |
20090162802 | ATTENUATING CUMBUSTION NOISE OF PREMIXED FLAMES - Disclosure is made of methods, systems, and apparatus for changing characteristics of noise of premixed flames supported on burners by heating burner passageways by an amount that attenuates combustion noises arising from premixed flames. Alternatively, attenuation occurs by controlling a temperature differential between a first point relative to a premixed flame and at least a second point in an uncombusted portion of a fuel/oxidizer mixture causing the flame | 2009-06-25 |
20090162803 | TWO CHAMBERED ILLUMINATING LIGHTER - A lighter comprises an inner lighter housing and an outer housing that slideably fits over the inner lighter housing to form a two chamber structure. An illumination assembly attaches to the lighter. The illumination assembly comprises a light emitting diode (LED) on an inside portion of the illumination assembly, positioned such that when lit, the LED illuminates the inside portion of inner lighter housing and the outer lighter housing. The inner and outer housings at least somewhat transparent, so as the illuminate an ambient portion of the atmosphere proximate to the lighter. A decorative insert can be provided between the inner lighter hosing and the outer lighter hosing. | 2009-06-25 |
20090162804 | ELECTRONIC CONTROL OF A WICK CONTAINING FLAMING ENTITY - The present invention is an apparatus that allows a torch, lantern, or candle user to ignite an actual flame electronically with the turn of a switch. Furthermore, this invention provides the means for the user to remove the flame without the need to blow it out or manually snuff the flame. | 2009-06-25 |
20090162805 | SYSTEM FOR MAKING CONICAL BONES IN ORGANIC TISSUES, AND A METHOD THEREFOR - A method and a system including templates ( | 2009-06-25 |
20090162806 | REPLACEMENT TOOTH - The present invention relates to a replacement tooth that includes a tooth body and a bracket. The bracket is coupled to the tooth body and includes at least one prong for communicating with an orthodontic apparatus. The bracket also includes a retaining plate that is embedded within the tooth for anchoring the bracket to the tooth body. | 2009-06-25 |
20090162807 | ORTHODONTIC BRACKET WITH ROTARY LIGATING COVER - The present invention provides designs for a self-ligating orthodontic bracket. According to one embodiment, the self-ligating orthodontic bracket includes a mounting base for attachment to a tooth surface, an archwire slot formed upon the base and sized for receiving an orthodontic archwire, a rotary ligating cover selectively rotatable between an open position permitting access to the archwire slot and a closed position covering the archwire slot, and one or more locking features for holding the rotary ligating cover in a closed position. In one embodiment, the bracket includes one or more locking tabs on the rotary ligating cover aligned in coplanar relation to the rotary ligating cover and cooperatively mating with cutout portions in the base. In one embodiment, the bracket includes at least one resilient retention mechanism adjacent to the one or more locking tabs and aligned in coplanar relation to the rotary ligating cover. The resilient retention mechanism may include one or more relief channels permitting flexing of at least portions of the rotary ligating cover adjacent to the one or more locking tabs. | 2009-06-25 |
20090162808 | Apparatus in Dental Environment and Method for Controlling a Device Belonging to the Same - The present invention relates to an apparatus used in dental care environment and to a method for controlling a device belonging to the apparatus, especially to hygienic and ergonomic control of a device belonging to the apparatus in connection with dental care work. The invention includes at least one device ( | 2009-06-25 |
20090162809 | Apparatus for positioning dental impression molds - A dental impression alignment guide comprising a frame which holds a conventional dental impression compound tray on one end and a laser source on the other end. The laser beam is split into two orthogonal fan shaped beams that project vertical and horizontal lines on the face of a patient. The lines are fixedly coupled to the impression compound tray, thus indicate the tray's position in the patient's mouth. The use of the alignment measuring tool facilitates the alignment of subsequent dentures in the articulated artificial jaw dentists use to verify fit and occlusion before moving dentures, appliances, or surgical procedures to the patient. | 2009-06-25 |
20090162810 | Ultrasonic dental insert and lighted handpiece assembly - An ultrasonic dental handpiece and insert assembly is provided. Scaler inserts that can be used to clean and polish tooth surfaces are particularly preferred. A sleeve is removably mounted on the handpiece. The handpiece contains a primary coil and the sleeve encloses a secondary coil, which are inductively coupled together so that electromagnetic energy can be transferred between them. A flexible light guide member having a light source such as a light-emitting diode extends from the sleeve. The light guide can bend and flex in any direction allowing the light source to emit light in any direction. | 2009-06-25 |
20090162811 | Dental prophylaxis angle and handpiece assembly - A dental prophylaxis angle and handpiece assembly for cleaning and polishing teeth is provided. The dental prophylaxis angle is removably attached to the dental handpiece by an interlocking mechanism that includes extension locking tabs, a locking annular member, and an interlocking drive member in the handpiece. The prophy angle is securely snap-fitted onto the handpiece and locked in place so that it has minimal lateral movement. After the prophy angle has been used to treat a patient, it can be removed easily from the handpiece and disposed thereof. | 2009-06-25 |
20090162812 | DENTAL COMPOSITE SHAPING BURS - A system of conically shaped dental burs mounted on the end of cylindrical shafts is disclosed. In one embodiment, the tip of the cone presents an abrasive surface, while the basal edge of the conical surface presents a smooth surface useful for limiting the overall penetration of the bur. This may be used for crafting grooves or fossae on dental surfaces. In an alternate embodiment the tip portion of the conical bur presents the smooth limiting surface, and the peripheral edges are abrasive, so that this bur is useful for reducing cusps or ridges. The burs are used with the axis of rotation perpendicular to the plane of the tooth. They used alternately by the dental practitioner in the detailed sculpting of dental composite fillings. The shaft portion incorporates finished shapes commonly used for either high speed or low speed bur drive systems. | 2009-06-25 |
20090162813 | Method for (semi-) automatic dental implant planning - A method and system for (semi-) automatic dental implant planning (A) is described including (a) means for creating 3D models of a tooth setup (b) and/or means for creating 3D models of parts of the jaw, (c) means for detecting zones in the jaw where implants can (or optionally cannot be placed), (d) means for detecting restorative elements in the tooth setup, (e) means for determining candidate implant dimensions, positions, orientations and configurations, (f) means for obtaining implant plans, (g) means for comparing implant plans to each other or to given criteria, (h) means for selecting or improving an implant plan. | 2009-06-25 |
20090162814 | VIDEO-CAPTURED MODEL VEHICLE SIMULATOR - The present invention provides a video-captured model vehicle simulator including at least one model vehicle, a track layout, at least one video imaging unit, at least one computer, at least one input device and/or control system and a customised software application whereby the simulator provides a user with a realistic simulation of the operation of a vehicle. | 2009-06-25 |
20090162815 | ZI WEI DOU SHU ANALYZING SYSTEM AND METHOD THEREOF - An analyzing method of a zi wei dou shu system is disclosed. The method includes the steps of: generating a birth chart according to personal information of a user; quantifying the information in the birth chart; drawing a period of fortune trend curve based on transits of time, whereby the user can refer to numerical information to interpret his/her own fortune. | 2009-06-25 |
20090162816 | HEALTH MANAGEMENT CUFF - A cuff for a health managing system includes a strand having first and second terminal ends. A plurality of beads, each presenting a numerical or a non-numerical value, are slidably retainable and movable along the strand. The beads are movable between various positions between the first and second terminal ends for tabulating a health management system or preventing movement of the beads between the first and second terminal ends. | 2009-06-25 |
20090162817 | KISSING SHIELD GAME AND METHOD OF USE THEREOF - A kissing shield game having a gaming member having at least two sides with different color associated therewith as well as a predetermined set of alphanumeric symbols associated therewith, a plurality of thin, flexible membranes substantially impervious to microorganisms, and a resettable timer. | 2009-06-25 |
20090162818 | Method for the determination of supplementary content in an electronic device - The invention relates to a method for replacing subtitle text with occasional word or idiom translations. In the method an initial language skill is determined. A content object is selected for presentation. A content vocabulary associated with the content object is determined. The content vocabulary is reduced based on the initial language skill to produce a target vocabulary. The presentation of said content object is started in the electronic device. The presence of a word in the content object is detected. The translation of the word is displayed on a display of the electronic device, if the word belongs to the target vocabulary. | 2009-06-25 |
20090162819 | TEACHING AID DEVICE AND METHOD OF TEACHING - A method for instructing mathematics includes providing a work surface to a visually impaired student; providing a plurality of movable elements for use in connection with the work surface, each of the movable elements comprising on a front surface thereof at least a portion of a visible mathematical symbol readable via eyesight, each of the movable elements further comprising Braille indicia on the front surface thereof corresponding to the at least a portion of the visible mathematical symbol, each of the moveable elements being movable to any position on the work surface; and having the student arrange a plurality of the moveable element on the work surface to form a standard mathematical expression wherein the mathematical expression comprises multiple lines set forth in a vertical arrangement. | 2009-06-25 |
20090162820 | Educational Simulator for Trasesophageal Echocardiography - An educational simulator for transesophageal echocardiography device, which includes a human phantom patterned after a human upper body having a neck, an esophagus and a stomach which communicate with each other, and a heart, a dummy probe which is patterned after a genuine ultrasonic probe and of which the tip is embedded with a magnet, a sensor which detects the insertion length and rotation angle of the dummy probe and is placed in the said neck, magnetic sensors which sense the magnetism of the said magnet, a three-dimensional image data archive which stores three-dimensional image data of echocardiography, a CPU which calculates the position, inclination and direction of the dummy probe on the basis of information from each said sensor and clips tomographic image data from the three-dimensional image data on the basis of the calculation, and a display section which shows the clipped tomographic image data as two-dimensional images. | 2009-06-25 |
20090162821 | SPINAL SURGERY MODELING SYSTEM - Provided is a novel spinal surgery modeling system that includes a platform having attachment elements and vertical tensioner supports positioned on a platform so as to effectively connect to and secure a model of a spinal column by use of tension members. The modeling system being configured to support surgical procedure training or surgical plan rehearsals as needed. Also provided is kit including the disclosed system. | 2009-06-25 |
20090162822 | Internet-based mobile learning system and method therefor - A mobile learning system and method therefor to provide video-based lectures to PDA devices over a network. To build a database, MIIME type PDA-compatible learning objects are generated from raw files (PowerPoint, MSWord, Macromedia Flash files) of an educator. The system includes a host server to provide an interactive server application to receive and convert raw files to audio/video presentations. Each learning object is classified according to a hierarchal educational structure and converted to a plurality of MIME files that match respective video platforms of a variety of PDA devices. The MIME files are tagged with authorship information, title, and/or other search parameters. A database stores these files on a network storage device for subsequent access by a learner's PDA. The system and method conveniently allow students to use their portable devices as a learning tool, and also enables a wider dissemination of expert instructional material throughout the world. | 2009-06-25 |
20090162823 | INTERACTIVE TEACHING AND LEARNING DEVICE - The invention relates to a device which allows to preferably explain and demonstrate three-dimensional objects, such as anatomic models or also models and exhibits for museums and fairs. According to the invention the model | 2009-06-25 |
20090162824 | AUTOMATED LEARNING FROM A QUESTION AND ANSWERING NETWORK OF HUMANS - A QA robot learns how to answer questions by observing human interaction over online social networks. The QA robot observes the way people ask questions and how other users respond to those questions. In addition, the QA robot observes which questions are most helpful and analyzes those questions to identify the characteristics of those questions that are most helpful. The QA robot then uses those observations to enhance the way it answers questions in the future. | 2009-06-25 |
20090162825 | COURSE EVALUATION APPARATUS AND COURSE EVALUATION METHOD - A course evaluation apparatus includes an estimated-course-group generation portion that generates a plurality of estimated course groups for a movable body; and a course evaluation portion that performs a course evaluation on the plurality of estimated course groups with respect to at least two different evaluation criteria. | 2009-06-25 |
20090162826 | Mass Customization Method for High School and Higher Education - MCMEd is an institutional level Business Method claim for a new design of the structure and processes of learning to facilitate mass production/customization of High School and Higher Education. | 2009-06-25 |
20090162827 | Integrated assessment system for standards-based assessments - A computer integrated assessment system for standards-based assessments wherein the assessments conform to recorded standards, the system includes algorithms for directing the generation of a plan of a series of customized assessments aligned to respective selected standards of the recorded standards wherein each of the customized assessments are set for different times within a period of time; and algorithms for enabling a user to generate a test in one of the customized assessments wherein one of the selected standards of the one customized assessment is displayed to the user during generation of questions for the test. During generation of tests, repeating of questions or questions on selected subject matter can be prevented. Individuals or groups can be selected to the customized assessments. Accuracy in grading of answer sheets by scanning is improved by an algorithm determining the lightest and darkest answer mark to determine the intended answer. Additionally student handheld devices can be used to answer questions in test with automatic grading or scoring. | 2009-06-25 |
20090162828 | Method and system to provide a video-based repository of learning objects for mobile learning over a network - A method and system to provide video-based lectures accessible over a network by multiple PDA device types. To build a database, MIIME type PDA-compatible learning objects are generated from raw files (PowerPoint, MSWord, Macromedia Flash files) of an educator. The system includes a host server to provide an interactive server application to receive and convert raw files to audio/video presentations. Each learning object is classified according to a hierarchal educational structure and converted to a plurality of MIME files that match respective video platforms of a variety of PDA devices. The MIME files are tagged with authorship information, title, and/or other search parameters. A database stores these files on a network storage device for subsequent access by a learner's PDA. The network and system conveniently allow students to use their portable devices as a learning tool, and also enables a wider dissemination of expert instructional material throughout the world. | 2009-06-25 |
20090162829 | EXTENSIBLE EXAM LANGUAGE (XXL) PROTOCOL FOR COMPUTER BASED TESTING - A memory stores a plurality of first data structures, which includes element specific data objects indicating a classification of at least one of the plurality of segments of the test definition language, and second data structures, which include attribute specific data objects indicating at least one attribute of the segments of the test definition language implemented by a computer. A method for computer-based testing includes authoring a test specification and content of the at least one test using a test definition language, compiling the test specification and content of the at least one test to create a compiled test specification and content, which includes validating the test specification and content, storing the compiled test specification and content to a resource file, and retrieving the compiled test specification and content from the resource file during delivery of the test. | 2009-06-25 |
20090162830 | REAGENTS AND METHODS FOR CLASSIFYING LEUKOCYTES - A reagent for classification of leukocytes includes (a) at least two cationic surfactants; (b) at least one organic compound bearing a hydrophobic group and an anionic group; (c) a buffer for adjusting pH into a range of approximately 2-8. Also disclosed is a method for classifying leukocytes with the reagent. With the reagent and method, erythrocytes are lysed rapidly and classification of leukocytes into five groups is achieved in the same channel. The reaction may be carried out at approximately between 10-40° C. and scattered light signals may be detected at two angles for measuring the classification of leukocytes into five groups. | 2009-06-25 |
20090162831 | HUMAN PARVOVIRUS - The present invention relates to the discovery of a new human parvovirus, methods of detecting the parvovirus and diagnosing parvovirus infection, methods of treating or preventing parvovirus infection, and methods for identifying anti-parvoviral compounds. | 2009-06-25 |
20090162832 | Functional viral vectors for the overexpression or extinction of particular genes in plants, and applications - The invention relates to the use of genes which, in plants, encode proteins with a functional diversity in terms of silencing, comprising the selection of the gene with the level of effectiveness in order to construct a plant viral vector having the function of overexpressing or silencing particular genes. | 2009-06-25 |
20090162833 | TEST DEVICE FOR RAPID DIAGNOSTICS - Devices for detecting analytes or analogues thereof in a biological sample are disclosed. The device includes a solid support. The solid support has several juxtaposed zones. The sample is able to migrate from a sample receiving zone towards a detection zone. The analyte, if present, is detected in the detection zone. Both zones have material allowing a capillary flow of the sample through the zones. In between the zones, there is an intermediate zone of transport of the sample which is free from any capillary material. This allows the ample to migrate by gravitational forces on the support laid in a vertical position. Methods for detecting analytes or analogues thereof in a biological sample using the device are also disclosed. | 2009-06-25 |
20090162834 | MOLECULAR SEQUENCE OF SWINE RETROVIRUS AND METHODS OF USE - Purified nucleic acid which can specifically hybridize with the sequence of swine retroviruses. | 2009-06-25 |
20090162835 | Novel methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries - Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens. | 2009-06-25 |
20090162836 | Prognostic and Diagnostic Markers for Cell Proliferative Disorders of The Breast Tissues - The present invention relates to prognostic and diagnostic markers for cell proliferative disorders of the breast tissues. The present invention therefore provides methods and nucleic acids for the analysis of biological samples for features associated with the development of breast cell proliferative disorders. Furthermore, the invention provides for prognosis of treatment effects relating to drug therapy, in particular hormonal/antihormonal therapy, chemotherapy and/or adjuvant therapy. | 2009-06-25 |
20090162837 | Inactivated FCV vaccines - The present invention relates to improved inactivated feline calicivirus (FCV) vaccines. The invention also provides a process for producing stabilized inactivated FCV, and the use of such stabilized inactivated FCV, in the production of FCV immunogenic compositions. The invention further provides methods of inducing an immune response in an animal of the Felidae family, preferably a cat, using the immunogenic compositions according to the invention. | 2009-06-25 |
20090162838 | FLUORESCENCE RESONANCE ENERGY TRANSFER ENZYME SUBSTRATES - Disclosed are compounds of formula (I) wherein D | 2009-06-25 |
20090162839 | DIAGNOSIS AND PROGNOSIS OF CANCER BASED ON TELOMERE LENGTH AS MEASURED ON CYTOLOGICAL SPECIMENS - The present invention concerns a quantitative in situ assessment of mean telomere length, particularly in relation to nuclear area, for the diagnosis and/or prognosis of cancer. In particular aspects, the methods and compositions regard diagnosis and/or prognosis of bladder cancer, urothelial cancer, lung cancer, and lymphoma. | 2009-06-25 |
20090162840 | Methods and compositions for use in analyte detection using proximity probes - Methods and compositions for detecting an analyte in a sample are provided. In practicing the subject methods, a sample is combined with at least a pair of proximity probes that each include an analyte binding domain and a nucleic acid domain. The resultant mixture is then contacted with a pair of asymmetric nucleic acid connectors. Proximity dependent connector mediated interaction between the nucleic acid domains of the proximity probes is then detected to determine the presence of the analyte in the sample. Also provided are kits and systems for practicing the subject methods. | 2009-06-25 |
20090162841 | Method of selecting a desired protein from a library - Described is an improved method of selecting a member of a specific binding pair (sbp) having a desired specify, preferably an antibody, from a library expressing said member of a sbp, preferably a phage-display antibody library. | 2009-06-25 |
20090162842 | Circulating mRNA as diagnostic markers - Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclampsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more mRNA species encoding human chorionic gonadotropin β subunit (hCG-β), human placental lactogen (hPL), human corticotropin releasing hormone (hCRH), KiSS-1 metastasis-suppressor (KISS1), tissue factor pathway inhibitor 2 (TPFI2), placenta-specific 1 (PLAC1), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and comparing the amount of the mRNA species with a standard control. | 2009-06-25 |
20090162843 | IDENTIFICATION OF HPV16 LINEAGE GROUP - A method for identification of an HPV16 lineage group in a sample, comprising contacting such nucleic acid simultaneously with three probes, each probe being capable of specific hybridization across positions 143 and 145 of a HPV 16 genome. | 2009-06-25 |
20090162844 | Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase - This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides. | 2009-06-25 |
20090162845 | Affinity tag nucleic acid and protein compositions, and processes for using same - The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups. | 2009-06-25 |
20090162846 | SENP1 as a marker for cancer - The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample. | 2009-06-25 |
20090162847 | RAPID DETECTION OF THE "HIGH-VIRULENT" ST-17 CLONE OF GROUP B STREPTOCOCCUS - The present invention relates to polynucleotides enabling the rapid, simple and specific detection of Group B | 2009-06-25 |
20090162848 | Noxin, a novel stress-induced gene involved in cell cycle and apoptosis - The invention provides for novel noxin polypeptides and nucleic acids from humans, rats, and mice and to related compositions and uses. The invention also provides for the creation of non-human, transgenic mammals which have, incorporated in their genome, DNA that includes a sequence of a mammalian noxin gene that does not produce noxin polypeptides, i.e. a noxin knockout mouse. | 2009-06-25 |
20090162849 | IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA - The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group. | 2009-06-25 |
20090162850 | NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 125P5C8 USEFUL IN TREATMENT AND DETECTION OF CANCER - A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization. | 2009-06-25 |
20090162851 | DETECTION OF NUCLEIC ACIDS BY TYPE SPECIFIC HYBRID CAPTURE METHOD - Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid target sequences. The method produces DNA-RNA hybrids which can be detected by a variety of methods. | 2009-06-25 |
20090162852 | BAALC EXPRESSION AS A DIAGNOSTIC MARKER FOR ACUTE LEUKEMIA - Overexpression of the gene, BAALC, in biological samples from a patient is prognostic for tumor aggressiveness and unfavorable patient outcome. The present invention provides polynucleotide primers and probes for assaying for overexpression of BAALC transcripts. Kits containing the primers and probes are also provided. Also provided are antibodies for assaying for overexpression of BAALC proteins as well as peptide immunogens for producing the anti-BAALC antibodies. The present invention also provides methods for characterizing acute myelogenous leukemia, chronic myelogenous leukemia and prostate cancer in a patient, base on detection of BAALC overexpression. | 2009-06-25 |
20090162853 | METHODS AND DEVICES FOR CELLULAR ANALYSIS - Embodiments of the present invention are directed to improved methods and devices for analyzing a cell, aggregated cells, or a solid tumor. Such methods and devices are, for example, useful in the field of pathology and can provide improved cell processing and analytical results. | 2009-06-25 |
20090162854 | METHODS AND KITS FOR DIAGNOSIS OF SCHIZOPHRENIA - The present invention provides methods and kits for the diagnosis of schizophrenia, which employ mitochondrial complex I as a peripheral biological marker for schizophrenia. In an embodiment of the invention, the present invention provides a method for diagnosing schizophrenia in a subject by determining the level of m-RNA or protein mitochondrial complex I subunits and its activity by determining the cellular basal respiration through complex I enzyme. | 2009-06-25 |
20090162855 | Identification of Genetic Variants Associated with Increased Severity of Pulmonary Disease - A method of determining a genetic component contributing to the severity of a pulmonary disease in a patient comprises determining the presence or absence of one or more single nucleotide polymorphisms (SNPs) in the Endothelin Receptor A (EDNRA) gene or the Interleukin-8 (IL-8) gene of the patient. The SNPs are rs5335 or rs1801708 for EDNRA, or rs4O73 for IL-8. The pulmonary disease may be cystic fibrosis or lymphangioleimyomatosis. Determining the presence or absence of one or more of SNPs rs5335 or rs1801708 in the EDNRA gene or rs4073 in the IL-8 gene of the patient may also be used in a method of treating a patient having a pulmonary disease. A kit may comprise one or more probes for determining the presence or absence of one or more of SNPs rs5335 and rs1801708 in the EDNRA gene or the SNP rs4073 in the IL-8 gene. | 2009-06-25 |
20090162856 | RNA DETECTION METHOD - It is an object of the present invention to provide a method for rapid, convenient, and highly sensitive detection of trace RNA wherein a risk of contamination is low. The present invention provides a method for amplification of nucleic acid which comprises the steps of: (i) allowing a reverse transcriptase to act on RNA so as to produce a nucleic acid fragment; and (ii) performing substantially isothermal incubation of a reaction solution containing at least one type of deoxynucleotide triphosphate, at least one type of DNA polymerase having strand displacement activity, a divalent cation, a surfactant accounting for at least 0.01% of the solution, at least two types of oligonucleotide primers, and the nucleic acid fragment as a template obtained in the step (i) so as to perform a polymerase reaction that is initiated from the 3′ ends of the primers and thus amplify the nucleic acid fragment. | 2009-06-25 |
20090162857 | Pharmaceutical Compositions and Methods for Delivering Nucleic Acids Into Cells - The present invention relates to methods of delivering nucleic acids into cells using a nucleic acid binding molecule containing a multimeric or spacer-incorporated protein transduction domain (PTD). The invention also relates to novel compositions that contain a nucleic acid complexed or conjugated with a nucleic acid binding molecule. The nucleic acid binding molecule may contain a multimeric or spacer-incorporated PTD, and may further contain a nucleic acid binding region. The nucleic acid complexes or conjugations of the present invention may be employed to inhibit expression of a target gene, and/or determine the function of a target gene. | 2009-06-25 |
20090162858 | Orthogonal chemical inducer of dimerization - A method for identifying a molecule as being able to bind a protein target in a cell, comprising (a) covalently bonding the molecule to trimethoprim (TMP) to form a screening molecule, (b) introducing the screening molecule into the cell which (A) expresses (i) a first fusion protein comprising a binding domain capable of binding TMP, and (ii) a second fusion protein comprising the protein target, and (B) comprises a reporter gene, wherein one of the fusion proteins comprises a DNA-binding domain and the other fusion protein comprises a transcription activation domain and wherein expression of the reporter gene is conditioned on the proximity of the DNA-binding domain to the transcription activation domain; and (c) determining whether the screening molecule binds to the first fusion protein and to the second fusion protein by determining whether the cell expresses the reporter gene, wherein expression of the reporter gene indicates that the molecule binds the protein target and wherein lack of expression of the reporter gene indicates that the molecule does not bind the protein target. | 2009-06-25 |
20090162859 | Compositions, methods and systems for inferring canine breeds for genetic traits and verifying parentage of canine animals - Methods and systems are provided for managing companion animal subjects in order to maximize their individual health and potential performance and to maximize profits obtained in breeding and marketing the companion animal subjects. The methods and systems draw an inference of a phenotype for a genetic trait of a companion animal subject by determining the nucleotide occurrence of at least one companion animal SNP that is determined to be associated with the phenotype. The methods and systems described can be utilized to identify individual animals, determine or verify parentage of a single dog from any breed if the putative parent(s) are also available for testing, and are associated with, and predictive of, canine breeds. The inference is used in some aspects to diagnose a health condition or predisposition of a companion animal subject. | 2009-06-25 |
20090162860 | Method of nucleic acid sequence detection and nucleic acid sequence detection substrate - According to an aspect of the present invention, a pair of oligonucleotide strands are anchored onto the surface of a substrate by immobilizing one of the ends thereof onto the substrate. Each of the immobilized oligonucleotide strands is bound to a target nucleic acid sequence (single-stranded) having complementary sequences thereto to form a cross-linked structure on the substrate, thereby forming a finely reticulated space. Ligands are captured by this reticulated space through physical adsorption and caused to color with active substances reactive to the ligands. As a result of this, the present invention is capable of highly sensitively detecting even an exceedingly small concentration of a particular target nucleic acid sequence to be detected, at low cost and for a short time. | 2009-06-25 |
20090162861 | METHOD FOR SUPPRESSING A FRET SIGNAL, FRET SIGNAL SUPPRESSOR AGENTS AND USE IN A METHOD FOR MULTIPLEXING BIOLOGICAL EVENTS - The invention relates to a method for suppressing the FRET emitted by a reaction medium containing a pair of fluorescent FRET partner conjugates specific for a biological event, characterized in that a FRET signal killer which does not disturb said biological event is introduced into this medium. | 2009-06-25 |
20090162862 | DEVICE AND METHOD FOR THE AUTOMATED AND REPRODUCIBLE PRODUCTION OF CELL OR TISSUE SAMPLES THAT ARE TO BE ANALYZED AND ARE ARRANGED ON OBJECT SUPPORTS - An automatically operating apparatus designed as a table-top apparatus for the reproducible production of cell or tissue samples to be examined and arranged on specimen slides comprises, located its center, a rotatably supported, advance device having arranged on its periphery a plurality of modular processing stations at a distance from the advance device. Receiving devices provided in the peripheral region of the advance device are disposed to receive specimen slides on which automatically segmented cell and tissue segments can be positioned in a reproducible and correctly aligned manner. The cell and tissue segments are durably fixed in position on the specimen slides with the use of a curable adhesive, and the specimen slides, after being delivered, are subjected to further treatment processes in a further treatment device. | 2009-06-25 |
20090162863 | Nucleic acid detection probe - It is intended to provide a nucleic acid detection probe that is designed with a high degree of flexibility. The present invention provides a nucleic acid detection probe used in nucleic acid detection, wherein the amount of a particular target gene present in a sample is examined by simultaneously hybridizing, to the target nucleic acid, a first probe labeled at one end with a fluorophore and a second probe labeled with a quencher at an end different from the labeled end of the first probe and observing quenching attributed to the interaction between the fluorophore and the quencher. | 2009-06-25 |
20090162864 | BIOLOGICAL SUBSTANCE DETECTION CARTRIDGE,BIOLOGICAL SUBSTANCE DETECTION APPARATUS, AND BIOLOGICAL SUBSTANCE DETECTION METHOD - A biological substance detection cartridge, including: a reaction vessel for reacting a probe with a specific biological substance included in a sample solution, the reaction vessel having a region for fixing the probe for detecting the biological substance; a porous membrane facing the inside of the reaction vessel; a gas-liquid separation membrane superposed with the porous membrane; and a air discharge component which is provided on the opposite side of the gas-liquid separation membrane from the side contacting the porous membrane, and with which the interior can be kept at negative pressure during the reaction between the biological substance and the probe. | 2009-06-25 |
20090162865 | BREAST CANCER RELATED PROTEIN, GENE ENCODING THE SAME, AND METHOD OF DIAGNOSING BREAST CANCER USING THE PROTEIN AND GENE - An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a method of diagnosing breast cancer using an antibody specifically binding to the protein and a method of diagnosing breast cancer by determining whether the gene is expressed in a cell or not, are provided. | 2009-06-25 |
20090162866 | COMPOSITIONS AND METHODS FOR OBTAINING NUCLEIC ACIDS FROM SPUTUM - The present invention relates to compositions and methods for preserving and extracting nucleic acids from saliva. The compositions include a chelating agent, a denaturing agent, buffers to maintain the pH of the composition within ranges desirable for DNA and/or RNA. The compositions may also include a reducing agent and/or antimicrobial agent. The invention extends to methods of using the compositions of the invention to preserve and isolate nucleic acids from saliva as well as to containers for the compositions of the invention. | 2009-06-25 |
20090162867 | MUTATIONAL PROFILES IN HIV-1 REVERSE TRANSCRIPTASE CORRELATED WITH PHENOTYPIC DRUG RESISTANCE - The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e., drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis. | 2009-06-25 |
20090162868 | Gene Markers and Utilization of the Same - [Problems]To provide a gene marker which enables diagnosis of rejection, evaluation of the efficacy of an immunosuppressive agent, and determination of the presence or absence of immunological tolerance; methods that can be performed in a quick, simple, and convenient manner by using the gene marker as an indicator for diagnosing rejection, evaluating the efficacy of an immunosuppressive agent, identifying an immunosuppressive agent, selecting an immunosuppressive agent, determining the dose of an immunosuppressive agent, and judging the presence or absence of immunological tolerance; a kit; and a method for screening for an immunosuppressive agent or an immunological tolerance-inducing agent. | 2009-06-25 |
20090162869 | MEMBRANE MOLECULE EXPRESSED SPECIFICALLY IN ACTIVATED PLASMACYTOID DENDRITIC CELL - It is an object of the present invention to identify a membrane molecule that is specifically expressed on activated plasmacytoid dendritic cells, for the purpose of preventing or improving affection or disease such as cancer, autoimmune disease, allergy, or infectious disease by regulating the functions of dendritic cells capable of integrating an immune system. The present invention provides a protein having any one of the following amino acid sequences: | 2009-06-25 |
20090162870 | FATTY ACID SYNTHASE IN LIVER DISEASE - Methods and compositions for detecting elevated fatty acid synthase (FAS) expression in the liver of a subject are disclosed. The detection may be of expression in liver cells per se or in a bodily fluid of a subject. Also disclosed are methods for identifying the presence or absence of liver disease or pathology in relation to elevated FAS. The disclosed methods may be practiced with various compositions comprising reagents for detecting FAS expression as described herein. | 2009-06-25 |
20090162871 | Mutants of the factor VII-activating protease and detection methods using specific antibodies - Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified. | 2009-06-25 |
20090162872 | COMPETITIVE RECEPTOR BINDING ASSAY FOR DETECTING BETA-GLUCANS HAVING IMMUNOMODULATORY ACTIVITY IN A HUMAN CELL - The present invention provides a method for detecting a beta-glucan having immunomodulatory activity in a human cell, which uses a test cell line that stably expresses human dectin-1 molecule on the cell surface and does not express other glucan receptors and a specific amount of a marker beta-glucan that specifically binds to human dectin-1 molecule for detection. | 2009-06-25 |
20090162873 | GENE ENCODING A MULTIDRUG-RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7P15-21 AND USES THEREOF - The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell s susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance. | 2009-06-25 |
20090162874 | METHOD FOR SCREENING ANTICANCER SUBSTANCES, SET OR KIT FOR IMPLEMENTING SAID METHOD - A method for screening anticancer substances comprising the following steps:
| 2009-06-25 |
20090162875 | Peptide diagnostic agent for lyme disease - The present invention relates, e.g., to an isolated peptide consisting of the sequence MKKDDQIAAAIALRGMA (SEQ ID NO:1) or an active variant thereof, wherein the peptide or active variant can bind specifically to an antibody induced by a causative agent of Lyme disease (a pathogenic | 2009-06-25 |
20090162876 | MYELOPEROXIDASE ASSAYS - The present invention relates to methods and kits for determining autoantibodies to myeloperoxidase or a myeloperoxidase fragment and myeloperoxidase or a myeloperoxidase fragment in a test sample. | 2009-06-25 |
20090162877 | Methods to Identify Protein Arginine Deiminase 4 Inhibitors - In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay. | 2009-06-25 |
20090162878 | METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING SAPPB - The present invention provides methods (assays) for detecting and/or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPPβ. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided. | 2009-06-25 |
20090162879 | MEASURING DEVICE, MEASURING APPARATUS, AND MEASURING METHOD - A measuring device ( | 2009-06-25 |
20090162880 | THROMBOPLASTIN REAGENT WITH LONG-TERM STABILITY - The present invention is in the area of coagulation analysis and relates to a reagent which is based on recombinant or native tissue factor and phospholipids and which can be stabilized by adding a polyphenol. | 2009-06-25 |
20090162881 | METHOD OF MEASURING ADENINE NUCLEOTIDE - A high sensitivity electrochemistry type method for measuring adenine nucleotide which has a convenient and further miniaturized measuring device structure; is low in consumptive power; and does not require a treatment operation for substances that cause turbidity is provided. A method for measuring adenine nucleotide, which comprises a step A for converting adenosine triphosphate to adenosine diphosphate by an enzyme E | 2009-06-25 |
20090162882 | Methods for determining proteins and protein-bound compounds comprising enzymatic modification - The present invention relates to a method for quantifying a non-proteinaceous corn pound bound to one or more carrier proteins in a sample comprising the steps of: i) separating complexes of said non-proteinaceous compound bound to said one or more carrier proteins from the non-proteinaceous compound that is not bound to said one or more carrier proteins; ii) releasing the non-proteinaceous compound from said one or more carrier proteins by treating the complexes of (i) with one or more enzymes; and iii) quantifying the non-proteinaceous compound enzymatically released in step (ii). In a preferred embodiment, the non-proteinaceous compound is cobalamin or an analogue thereof, and the carrier protein is transcobalamin or haptocorrin. The invention further relates to a method for quantifying a glycoprotein in a sample comprising the steps of: i) treating a sample with deglycosylating enzyme; and quantifying said glycoprotein. In a preferred embodiment, said glycoprotein is haptocorrin. | 2009-06-25 |
20090162883 | Alzheimer's Disease Secretase, APP Substrates Thereof, and Uses Thereof - The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the α-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease. | 2009-06-25 |
20090162884 | Method of disulfide crosslink forming in vitro protein synthesis - It is an objective of the present invention to provide a method of synthesizing a protein having disulfide bonds using a reconstituted protein synthesizing system in a convenient manner with high efficiency. It has been found that a protein having the activity can be obtained and synthesized with good efficiency by using a reconstituted protein synthesizing system comprising purified components, from which enzymes and substrates influencing an oxidation-reduction state are removed and in which a state of redox equilibrium between disulfide and thiol is artificially regulated. Such system is used instead of a cell extract or a crude fraction thereof that contains various enzymes and substrates that maintain a reduced state, such as thioredoxin reductase [EC 1.6.4.5] and glutathion reductase [EC 1.6.4.2], resulting in difficulty in conditioning a redox state. | 2009-06-25 |
20090162885 | Systems and methods for measuring fluid properties - A fluid property measurement system for measuring free stream particulates comprises a fluid movement device positioned within a fluid container which is configured to cause fluid flow within the fluid container along a fluid flow path when a fluid is present. A constricted region along the fluid flow path generates a region of concentrated streamlined flow within the constricted region and mixing of the fluid outside of the constricted region. A property measuring device is positioned with respect to the constricted region to measure fluid properties in the region of streamlined flow. | 2009-06-25 |
20090162886 | Screening Method of Glutathione-Increasing Substance - As a means for treating diseases such as neurodegenerative diseases, malignant tumors and infectious diseases, a method for screening a substance increasing glutathione is provided. According to this method, by contacting a test substance with a cell expressing a GTRAP3-18 protein, a substance decreasing the amount of expression of the GTRAP3-18 protein or inhibiting a function of the GTRAP3-18 protein is specified as a target substance. | 2009-06-25 |
20090162887 | Particle analysis in an acoustic cytometer - The present invention is a method and apparatus for acoustically manipulating one or more particles. | 2009-06-25 |
20090162888 | SAMPLE CONTROL FOR CORRECTION OF SAMPLE MATRIX EFFECTS IN ANALYTICAL DETECTION METHODS - Methods and systems are described suitable to determine the effects of sample matrix on the detection of a label so as to allow correction for these sample matrix effects when using the label in an analytical detection technique. The method is particularly advantageous for use in a disposable molecular diagnosis cartridge. | 2009-06-25 |
20090162889 | GENE REPORTER ASSAY, KIT, AND CELLS FOR DETERMINING THE PRESENCE AND/OR THE LEVEL OF A MOLECULE THAT ACTIVATES SIGNAL TRANSDUCTION ACTIVITY OF A CELL SURFACE PROTEIN - The present invention relates to a commercializable cell and to a gene reporter assay method and a kit which use this cell to determine the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein. This cell is treated in such a manner that it will have a sufficiently long shelf life for its intended purpose, whereupon at the end of its useful shelf life or at the end of its use, i.e., in an assay, the cell undergoes cellular death. | 2009-06-25 |
20090162890 | IDENTIFYING THERAPEUTIC COMPOUNDS BASED ON THEIR PHYSICAL-CHEMICAL PROPERTIES - The present invention is directed to rapid and efficient methods of identifying therapeutic compounds by allowing only the most favorable molecules initially selected based on their physical-chemical profile falling within a range predefined by the physical-chemical/biological relationship of a previously tested small subset of compounds of same core structure to be assayed; and to the therapeutic compositions identified by said methods. | 2009-06-25 |