25th week of 2013 patent applcation highlights part 51 |
Patent application number | Title | Published |
20130157266 | ABSCRIPTION BASED MOLECULAR DETECTION OF DNA METHYLATION - The present invention provides methods for detecting biomarkers based on Abscription®, abortive transcription technology. Particularly, the present invention provides bisulfate free methods for detecting methylation of CpG islands from small samples containing DNA, including formalin fixed, paraffin embedded samples. The methods are suitable for multiplexing and can be used to analyze multiple CpG islands from a single sample in a short time. | 2013-06-20 |
20130157267 | Marker for Cancer Prognosis and Methods Related Thereto - The present invention is related to the novel discovery that HIF-2α, but not HIF-1 a, selectively regulates adenosine A | 2013-06-20 |
20130157268 | PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE 1 GAMMA SPLICE VARIANTS AS BIOMARKERS AND DRUG TARGETS FOR EPITHELIAL CANCERS - The present invention relates generally to the field of phosphatidylinositol based signaling pathways, and more specifically to the use of novel members of these pathways for disease prognosis and treatment. In some aspects, the present invention relates to the use of novel splice variants of type I phosphatidylinositol phosphate kinase γ, named PIPKIγ 700 and PIPKIγ 707, to determine breast cancer and breast cancer prognosis. | 2013-06-20 |
20130157269 | METHOD OF DETERMINING A RATIO OF RNA SPECIES IN A SAMPLE - A method of amplifying DNA from RNA in a sample by using circular RNA is provided. | 2013-06-20 |
20130157270 | Marker of Diagnosis and Prognosis in Multiple Sclerosis - The present invention provides a method for determining whether an individual with relapsing-remitting multiple sclerosis will suffer a relapse. In the method, measuring the level of Response Gene to Complement (RGC)-32 is measured in the individual, where a significantly lower level of RGC-32 therein indicates that the individual will have or is having a relapse of multiple sclerosis. | 2013-06-20 |
20130157271 | Systems and Methods Using External Heater Systems in Microfluidic Devices - The present invention relates to methods and systems that result in high quality, reproducible, thermal melt analysis on a microfluidic platform. The present invention relates to methods and systems using thermal systems including heat spreading devices, including interconnection methods and materials developed to connect heat spreaders to microfluidic devices. The present invention also relates to methods and systems for controlling, measuring, and calibrating the thermal systems of the present invention. | 2013-06-20 |
20130157272 | METHODS AND COMPOSITIONS INVOLVING MIR-135B FOR DISTINGUISHING PANCREATIC CANCER FROM BENIGN PANCREATIC DISEASE - Provided are methods and compositions for identifying a miRNA profile for a particular condition, such as pancreatic disease, and using the profile in assessing the condition of a patient. | 2013-06-20 |
20130157273 | Method for Nucleic Acid Testing - A Method for nucleic acid analysis involving the steps of receiving sample tubes which contain samples, receiving a test request for each sample (the test request specifying one or more assays to be conducted for said sample), obtaining one or more sample aliquots of each sample depending on if one or more assays are to be conducted, assigning each of the sample aliquots to one or more test classes according to the assay which is to be conducted for that sample aliquot and combining sample aliquots belonging to the same test class into the same batch, while the batch includes samples for which a first and samples for which a second assay is to be conducted. | 2013-06-20 |
20130157274 | MAGNETIC LYSIS METHOD AND DEVICE - A method for lysing cells is disclosed. The method includes stirring cells with a magnetic stir element in the presence of a plurality of cell lysis beads at a speed sufficient to lyse the cells. Also disclosed is a device for lysing cells. The device includes a container having a magnetic stir element and a plurality of cell lysis beads disposed therein. The container is dimensioned to allow rotation of the magnetic stir element inside the container. | 2013-06-20 |
20130157275 | OLIGONUCLEOTIDE MARKER AND METHOD FOR IDENTIFYING THE SAME - Provided are an oligonucleotide marker and a method of identifying a material using the same. The oligonucleotide marker makes it possible to analyze a trace amount of the material with high precision within a short time, has improved solubility in an oily solvent, and can improve a detection method such that the oligonucleotide marker can be detected within 2 hours. The oligonucleotide marker can label various products, including oil products and petroleum products, works of art and collections, and can also be used to conduct criminal investigations. | 2013-06-20 |
20130157276 | DEVICE AND METHOD FOR CONDUCTING DIRECT QUANTITIVE REAL TIME PCR - A method and device for performing direct quantitative real time PCR in a crude sample ( | 2013-06-20 |
20130157277 | DEVICE FOR CAPTURE AND LYSIS OF MICROORGANISMS FROM LIQUIDS AND METHODS OF USE THEREOF - Devices and methods for detecting microbial contaminants, such as bacteria and fungi, in fluids such as drinking water, pharmaceutical solutions and tissue culture media are provided. More particularly, provided are filtration devices for capture and processing of microorganisms from fluids, and improved methods for recovery, lysis and detection of microorganisms based on a combination of physical disruption with small beads and lysis solutions. | 2013-06-20 |
20130157278 | SETTING OF MULTIPLE PRIMING OLIGONUCLEOTIDES FOR SOLID GEL AMPLIFICATION IN HYDROGELS - The present invention provides for a novel system and method for amplification and detection of nucleic acids within a microfluidic device wherein multiple nucleotides capable of priming PCR are present within the system and substantially sequestered within separate hydrogel posts therein. | 2013-06-20 |
20130157279 | METHOD FOR DETECTING TARGET SUBSTANCE AND APTAMER SET, SENSOR, AND APPARATUS USED IN THE METHOD - A method for detecting a target substance involves: a step of preparing a complex ( | 2013-06-20 |
20130157280 | PLANT FARNESYLTRANSFERASES - This invention relates to an isolated nucleic acid fragment encoding a farnesyltransferase subunit. The invention also relates to the construction of a chimeric gene encoding all or a portion of the farnesyltransferase subunit, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the farnesyltransferase subunit in a transformed host cell. | 2013-06-20 |
20130157281 | Factor IXa Crystals, Related Complexes and Methods - The present invention relates to factor IXa complexes and crystals thereof as well as methods for identifying inhibitors of factor IXa. | 2013-06-20 |
20130157282 | CHEMILUMINESCENCE COMPACT IMAGING SCANNER - Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner. | 2013-06-20 |
20130157283 | RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD - A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or electro-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples. | 2013-06-20 |
20130157284 | COLORIMETRIC AND FLUORESCENT PROTEINS - The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths. | 2013-06-20 |
20130157285 | IDENTIFICATION OF INVASIVE AND SLOW-GROWING TUMORIGENIC CELL SUBSETS IN TUMORS - HA-based functional probes and a multiplexed targeting strategy for detection and isolation of invasive subpopulations in breast cancer cell lines. Methods for using HA metabolism for profiling and sorting breast cancer heterogeneity. As such, HA-based functional probes have appropriate targeting capacity and safety profiles for development as imaging and therapeutic agents for following repair and neoplastic disease processes such as breast cancer. | 2013-06-20 |
20130157286 | FLUIDIC CONNECTORS AND MICROFLUIDIC SYSTEMS - Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use. | 2013-06-20 |
20130157287 | BIOLOGICAL SUBSTANCE DETECTION METHOD - A biological substance detection method for detecting a biological substance specifically in a pathological specimen, comprising a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen, with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label. | 2013-06-20 |
20130157288 | IMMOBILISED-BEAD IMMUNOMULTIPLEX ASSAY - Embodiments of this invention include image-based systems and methods for detection of one or more analytes. A surface has identifiable analyte-specific capture particle(s) immobilised thereto at any point of an assay, to which different analytes attach due to the affinity of analyte-specific capture molecule(s) linked to the surface of the capture particle(s) for the analyte. Analyte-specific detector molecules with conjugated detection moieties are then attached to the analyte, and a computer assisted, image-based detection system captures images of the capture particles with or without attached analytes and detector molecules. By using different subsets of analyte-specific capture molecules, each subset having a characteristic identifiable feature; it is now possible to perform capture particle-based, rapid multiplex assays of biological and non-biological analytes without flow. These image-based systems can be used to aid in diagnosis of disease, evaluation of therapy for disease, or laboratory investigation. | 2013-06-20 |
20130157289 | IMMUNO-PET IMAGING OF ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR - Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided. | 2013-06-20 |
20130157290 | SOLUBLE ST2 AS A MARKER FOR DISEASE - The present invention relates to materials and methods concerning the IL-1 receptor family protein ST2. Use of soluble ST2 as a marker for cardiovascular disease or disease outcome is provided, in particular as a marker of the risk of mortality. | 2013-06-20 |
20130157291 | DIAGNOSTIC MARKER FOR LUNG CANCER COMPRISING HPaR AS ACTIVE INGREDIENT - Disclosed is a diagnostic marker for lung cancer comprising HpαR as an active ingredient. Because blood, which is relatively easy to sample, is employed as a specimen, the diagnostic kit and marker for lung cancer is very simple and does not subject patients to a load compared to conventional methods that are directed to a biopsy. In addition, the kit and marker of the present invention is useful in the early diagnosis of lung cancer thanks to its high diagnostic sensitivity and selectivity. | 2013-06-20 |
20130157292 | COMPOSITION FOR THE DIAGNOSIS OF OVARIAN CANCER OR PNEUMONIA COMPRISING THIOREDOXIN 1 AS ACTIVE INGREDIENT AND USE THEREOF - Disclosed are a composition for the diagnosis of ovarian cancer and/or pneumonia, comprising thioredoxin 1 as an active ingredient, and the use thereof. Also, a diagnostic kit for ovarian and/or pneumonia and a diagnosis method are provided. Because blood, which is relatively easy to be sampled, is employed as a specimen, the diagnostic method is very simple and does not impose a load on patients compared to conventional methods that are directed to a biopsy. In addition, the method is useful in the early diagnosis of ovarian cancer thanks to the high diagnostic sensitivity and selectivity thereof. Thioredoxin 1 can be used as a diagnostic marker for pneumonia, which is characterized by a decreased serum level, with high selectivity for pneumonia, thereby readily discriminating pneumonia from cancer as well as diseases other than cancer. | 2013-06-20 |
20130157293 | PHARMACEUTICAL MANUFACTURING METHODS - The invention describes methods for manufacturing oligoadenylate synthetase (OAS) proteins for use as active pharmaceutical ingredients in pharmaceutical compositions. A manufacturing method is described that produces large quantities of concentrated, highly active OAS protein for use in pharmaceutical compositions for the treatment of a variety of diseases including viral infection. Methods for monitoring and validating the manufacturing process are also described. | 2013-06-20 |
20130157294 | Methods and Compositions for the Diagnosis of Cancer Susceptibilities and Defective DNA Repair Mechanisms and Treatment Thereof - Methods and compositions for the diagnosis of cancer susceptibilities, defective DNA repair mechanisms and treatments thereof are provided. Among sequences provided here, the FANCD2 gene has been identified, and probes and primers are provided for screening patients in genetic-based tests and for diagnosing Fanconi Anemia and cancer. The FANCD2 gene can be targeted in vivo for preparing experimental mouse models for use in screening new therapeutic agents for treating conditions involving defective DNA repair. The FANCD2 polypeptide has been sequenced and has been shown to exist in two isoforms identified as FANCD2-S and the monoubiquinated FANCD-L form. Antibodies including polyclonal and monoclonal antibodies have been prepared that distinguish the two isoforms and have been used in diagnostic tests to determine whether a subject has an intact Fanconi Anemia/BRCA pathway. | 2013-06-20 |
20130157295 | XANTHURENIC ACID DERIVATIVE PHARMACEUTICAL COMPOSITIONS AND METHODS RELATED THERETO - The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: | 2013-06-20 |
20130157296 | RECOMBINANT PROTEIN CAPABLE OF BINDING SPECIFICALLY AND QUICKLY TO TROPONIN I DERVIVED FROM HUMAN MYOCARDIUM - Provided is a recombination protein which binds specifically to troponin I derived from human myocardium. The recombinant protein includes a light chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 63; and a heavy chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 65. | 2013-06-20 |
20130157297 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Alpha-2-HS-glycoprotein, Interleukin-9, Leukemia inhibitory factor, Macrophage colony-stimulating factor 1, Prolactin, and Stromal cell-derived factor 12 as diagnostic and prognostic biomarkers in renal injuries. | 2013-06-20 |
20130157298 | 2-(2-Hydroxybiphenyl-3-yl)-1H-Benzoimidazole-5-Carboxamidine Derivatives as Factor VIIA Inhibitors - The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed. | 2013-06-20 |
20130157299 | Tyrosine Kinome - Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention. | 2013-06-20 |
20130157300 | METHODS OF QUANTIFYING EXOSOME IN CELL CULTURE AND METHOD OF INCREASING RECOVERY RATE OF EXOSOME USING THE SAME - A method of detecting and recovering of exosomes in a sample, as well as a method of determining the recovery rate of exosomal recovery, and a method of screening for a material that induces secretion of the exosomes in a sample, which methods employ the use of a protease. | 2013-06-20 |
20130157301 | Diagnosis of bacterial meningitis based on the measure of ROS production in a sample of cerebrospinal fluid - The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reactive oxygen species (ROS); a high level of ROS production is indicative of the presence of activated polymorphonuclear neutrophils (PMNs) in said fluid, which in turn is a hallmark of bacterial infection. | 2013-06-20 |
20130157302 | METHOD FOR DETERMINING CAPABILITY OF A COMPOUND FOR INHIBITING A RECEPTOR USING CODON-OPTIMIZED NUCLEIC ACID - A method for determining a capability of a compound for inhibiting a receptor through a change of intracellular calcium ion when the receptor is activated is provided. Contacting a host cell genetically engineered to express an apo-clytin-II protein generated from a codon-optimized nucleic acid with a test compound, and then determining an amount of light generated. The intracellular calcium ion can be detected much more easily. | 2013-06-20 |
20130157303 | SULFATED POLYSACCHARIDE CAPABLE OF BINDING TO GROWTH FACTOR AND USE THEREOF - A biological substance which can enhance the proliferation and differentiation of cells; a method for evaluating the proliferation and differentiation of cells, which targets the biological substance; a composition for detecting the proliferation and differentiation of cells, which contains a molecule capable of binding to the biological substance; and a composition for enhancing the proliferation and differentiation of cells, which contains the biological substance. A part of a sulfated polysaccharide secreted from cells binds to a growth factor during the course of the proliferation and differentiation of the cells, that the amount of the sulfated polysaccharide capable of the above-mentioned binding and secreted from the cells correlates strongly with the progression of the proliferation and differentiation of the cells, and that the proliferation and differentiation of cells can be evaluated and the proliferation and differentiation of cells can be enhanced utilizing the sulfated polysaccharide. | 2013-06-20 |
20130157304 | METHOD FOR PREPARING HUMAN NEOPLASTICALLY TRANSFORMED CELLS - A method for preparing neoplastically transformed cells from human-derived cells, including the step of introducing human telomerase catalytic subunit (hTERT) gene, SV40 small T antigen (SV40ST) gene, and an antisense oligonucleotide derived from human 28S rRNA into the human-derived cells. The method for preparing neoplastically transformed cells from human-derived cells can be utilized when a variety of human normal cells are induced to be neoplastically transformed in order to elucidate cancer onset mechanisms, so that the method can be effectively utilized in search of target molecules for a new medicament. | 2013-06-20 |
20130157305 | METHOD AND SYSTEM FOR EVALUATION OF GRAFTS - A method and system for evaluating the competence for transplantation of a graft sample containing cells capable of multinucleation are provided. In one form, the method includes determining multinucleating ability as an indicator representing the capacity for multinucleation of the cells capable of multinucleation. | 2013-06-20 |
20130157306 | METHOD FOR DETERMINING A DEGREE OF INFECTION - A method for determining a degree of infection comprising the steps of i) preparing an un-isolated sample by adding a differentiating marker, suitably a meta-chromatic stain such as, for example, acridine orange to mammalian milk in an amount sufficient to provide a differentiation between cell types; ii) measuring a differential somatic cell count on the sample by means of a cytometer having a detection system sensitive to differences in the differentiating marker resulting from the marker becoming differently associated with different cell types in the sample; and iii) determining an indication of a degree of infection dependent on the measured differential cell count. | 2013-06-20 |
20130157307 | Process of Producing A Fermentation Product - The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more deamidases are present in the fermentation medium. | 2013-06-20 |
20130157308 | BIDIRECTIONAL PROMOTER REPORTER VECTOR FOR THE ANALYSIS OF DUAL REGULATORY ELEMENTS - A bidirectional expression vector is described that can be utilized to determine the existence and characteristics of bidirectional promoters. The bidirectional expression vector includes two different reporter genes in a head to head (5′ to 5′) arrangement. In addition, the bidirectional expression vector can include a polylinker region located between the heads of the two reporter genes that provides multiple cloning sites for nonexclusive examination of polynucleotide sequences. The vector can also include a splicing site and drug resistance. The bidirectional expression vector can be used to examine a polynucleotide sequence for the presence of divergent regulator regions and, following determination of a bidirectional promoter, can be utilized to further elucidate characteristics of the bidirectional promoter. | 2013-06-20 |
20130157309 | Methods of obtaining genetic competence in bacillus cells - The present invention relates to methods of obtaining genetic competence in non-competent | 2013-06-20 |
20130157310 | Method for Production and Use of Mite Group 1 Proteins - The present invention includes a method to produce a recombinant mite Group 1 protein in a methyltrophic yeast or an | 2013-06-20 |
20130157311 | Methods of Determination of Activation or inactivation of Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP) Hormonal Systems - An in vivo method of determining activation or inactivation of the atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) hormonal systems, the method comprising simultaneously detecting the presence or amount of atrial and brain natriuretic peptide prohormones (proANP and proBNP) or fragments thereof in a sample. | 2013-06-20 |
20130157312 | NOVEL INTERGENIC ELEMENTS FOR ENHANCING GENE EXPRESSION - The present invention relates to nucleic acid fragments and constructs comprising genomic nucleotide sequences, which are present upstream of Rb1 and p15C that are associated with intergenic transcription, for the production of a gene product of interest in a eukaryotic, preferably mammalian, host cell in the presence of a stringent selectable marker. The invention further relates to host cells comprising the nucleic acid constructs, to methods for generating the host cells and to methods for producing a gene product of interest using the host cells. | 2013-06-20 |
20130157313 | HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 2013-06-20 |
20130157314 | Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Heterocyclic Compound And Uses Thereof - The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a heterocyclic compound. The present invention also relates to methods of using the compositions. | 2013-06-20 |
20130157315 | Methods and Apparatuses - A method for amplifying nucleic acid from a higher eukaryotic, such as mammalian or plant, nucleic acid source, the method comprising (a) contacting a sampling device with the source of higher eukaryotic, such as mammalian or plant, nucleic acid such that following said contacting, higher eukaryotic such as mammalian or plant nucleic acid-containing material is adhered to at least part of the sampling device, wherein the sampling device, or part thereof to which the nucleic acid-containing material is adhered, is made of a suitable polymeric material; (b) introducing the sampling device or part thereof to which the nucleic acid-containing material is adhered into a reaction vessel which contains a reaction mixture for carrying out a nucleic acid amplification reaction, without any prior treatment of the nucleic acid-containing material; and (c) performing a nucleic acid amplification reaction. | 2013-06-20 |
20130157316 | INCREASED POLY (ALPHA 1,3 GLUCAN) YIELD USING BORIC ACID - A process for production of poly(α1,3 glucan) from a renewable feedstock, for applications in fibers, films, and pulps. The effect of addition of boric acid in increasing the yield of the desired end products, poly(α1,3 glucan) and fructose, and decreasing formation of the undesired by-product leucrose. | 2013-06-20 |
20130157317 | Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Dioxy Compound And Uses Thereof - The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a dioxy compound. The present invention also relates to methods of using the compositions. | 2013-06-20 |
20130157318 | METHOD FOR ENZYMATIC SACCHARIFICATION TREATMENT OF LIGNOCELLULOSE-CONTAINING BIOMASS, AND METHOD FOR PRODUCING ETHANOL FROM LIGNOCELLULOSE-CONTAINING BIOMASS - A method for the enzymatic saccharification of a lignocellulosic raw material, including adding a pretreated lignocellulosic raw material as a material suitable for an enzymatic saccharification reaction, together with an electrolyte containing a water-soluble salt, to water that contains a celluolose saccharification enzyme; saccharifying the raw material by an enzymatic saccharification reaction, as a suspension of the raw material having an electrical conductivity adjusted to 5-25 mS/cm; separating and recovering a reaction product and an enzyme-containing solution from the enzymatically saccharified treatment suspension; and recycling the recovered enzyme-containing solution as the enzyme for the enzymatic saccharification step. | 2013-06-20 |
20130157319 | Method for Simultaneous Fermentation of Pentose and Hexose - The present invention relates to a method for simultaneous fermentation of pentose and hexose. The present invention modifies the metabolic pathways of a target microorganism in order to enable the target microorganism to rapidly metabolize pentose and hexose at the same time. This present invention simplified the fermentation process, decreased the cost, and increased the efficiency of the fermentation process. | 2013-06-20 |
20130157320 | PROCESS FOR PRODUCING SULFUR-CONTAINING ALPHA-AMINO ACID COMPOUND - The present invention provides a novel process for producing a sulfur-containing α-amino acid compound such as methionine. A process for producing a sulfur-containing α-amino acid compound represented by the formula (2): wherein R | 2013-06-20 |
20130157321 | Use of Phosphoketolase for Producing Useful Metabolites - The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium. | 2013-06-20 |
20130157322 | PROCESS FOR PRODUCING ETHANOL AND ETHYLENE VIA FERMENTATION - A process for converting a substrate such as carbon monoxide to useful chemicals has been developed. The process involves providing a substrate comprising CO to a bioreactor which contains a culture of one or more micro-organisms and anaerobically fermenting the substrate to produce ethanol. The ethanol is next converted to one or more chemical products via the compound ethylene. The source of the CO can be an industrial process such as the ferrous metal products manufacturing. The microorganism can be | 2013-06-20 |
20130157323 | MUTANT MICROORGANISM HAVING HIGH PRODUCTION OF CADAVERINE, AND PREPARATION METHOD OF CADAVERINE USING SAME - The present invention relates to a mutant microorganism having a high ability to produce cadaverine, and a method for producing cadaverine using the same. More specifically, the invention relates to a mutant microorganism having a high ability to produce cadaverine wherein a gene involved in the cadaverine degradation or utilization pathway is inactivated or deleted, and to a method for producing cadaverine in high yield by culturing the mutant microorganism under aerobic conditions. The mutant microorganism according to the present invention is useful for producing a high yield of cadaverine which can be widely used in various industrial applications. | 2013-06-20 |
20130157324 | IN SITU EXPRESSION OF LIPASE FOR ENZYMATIC PRODUCTION OF ALCOHOL ESTERS DURING FERMENTATION - Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity. | 2013-06-20 |
20130157325 | Lipolytic Enzyme Variants - Molecular dynamics (MD) simulation on the three-dimensional structure of | 2013-06-20 |
20130157326 | INTEGRATED BIOPROCESSING FOR FUEL PRODUCTION - Systems and methods are provided for enhancing the integration of processes for recovering products from algae-derived biomass. The enhanced process integration allows for increased use of input streams and other reagents that are derived from renewable sources. This increases the overall renewable character of the products extracted from the algae-derived biomass. The process integration can include exchange of input streams or energy between an algae processing system and a system for processing non-algal biomass. One example of improving process integration is using oxygenates that are generated in a renewable manner as a reagent for enhancing the algae processing system. | 2013-06-20 |
20130157327 | MUTANT POLYHYDROXYALKANOIC ACID SYNTHASE GENE AND METHOD FOR PRODUCING ALIPHATIC POLYESTER USING THE SAME - A substitution mutation that improves polymerization activity of a polyhydroxyalkanoic acid synthase is identified. At least 1 amino acid residue selected from the group consisting of a histidine residue at position 17, a proline residue at position 71, a valine residue at position 131, a methionine residue at position 205, a leucine residue at position 230, and a proline residue at position 239 of a polyhydroxyalkanoic acid synthase derived from | 2013-06-20 |
20130157328 | CATALYTIC DEHYDRATION OF LACTIC ACID AND LACTIC ACID ESTERS - This invention relates to catalytic dehydration of lactic acid derived from biological fermentation and its esters into acrylic acid and acrylic acid esters respectively. Disclosed in this invention are chemical catalysts suitable for industrial scale production of acrylic acid and acrylic acid esters. This invention also provides an industrial scale integrated process technology for producing acrylic acid and acrylic acid esters from biological fermentation using renewable resources and biological catalysts. | 2013-06-20 |
20130157329 | SYSTEM AND PROCESS FOR CORRECTING CONSTANT VOLUME ACIDITY OF FERMENTATIVE MEDIA FOR PRODUCING ORGANIC ACIDS | 2013-06-20 |
20130157330 | L-MALATE PRODUCTION BY METABOLICALLY ENGINEERED ESCHERICHIA COLI - A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein. | 2013-06-20 |
20130157331 | PNP GENE MODIFICATION FOR IMPROVED XYLOSE UTILIZATION IN ZYMOMONAS - The endogenous pnp gene encoding polynucleotide phosphorylase in the | 2013-06-20 |
20130157332 | GENE INACTIVATION ALLOWING IMMEDIATE GROWTH ON XYLOSE MEDIUM BY ENGINEERED ZYMOMONAS - cells that are genetically engineered to have a disrupted aldose reductase gene such that aldose reductase activity for conversion of xylose to xylitol in the presence of NADPH is reduced by greater than 90%, and that are engineered to express a xylose utilization metabolic pathway, were found to have the ability to gro on medium containing xylose as the only sugar without adaptation in media containing xylose. | 2013-06-20 |
20130157333 | METHOD OF TREATING ETHANOL PRODUCTION BYPRODUCTS - A method of treating ethanol production byproduct is provided by treating wet distillers grain or stillage with a solution containing at least one α-hydroxysulfonic acid to produce at least one fermentable sugar containing product. Fermentable sugar useful for the production of biofuels or ethanol can be produced from such methods. The α-hydroxysulfonic acid can be easily removed from the product and recycled. | 2013-06-20 |
20130157334 | PROCESS FOR CONVERTING A LIGNOCELLULOSIC BIOMASS - A process for converting a lignocellulosic biomass comprising
| 2013-06-20 |
20130157335 | BIOMEMORY DEVICE COMPRISING HETEROLAYER OF RECOMBINANT PROTEIN AND INORGANIC PARTICLE - The present invention relates to a biomemory device, comprising (a) a substrate; and (b) a heterolayer comprising a protein having a redox potential and an inorganic particle; wherein the heterolayer is immobilized on the substrate. By applying inorganic particles, the present invention provides a biomemory device capable of enhancing low current signals detected electron transfer between biomolecules and substrates up to at least five (5) times greater signals. The present invention is capable of controlling the redox states with help of redox potentials of proteins depending on applied potential. The present invention provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule. | 2013-06-20 |
20130157336 | METHODS AND COMPOSITIONS FOR OXIDIZING BISPHENOL A - Disclosed are methods, compositions and kits pertaining to polymer coatings that entrap enzymes, specifically enzymes capable of degrading bisphenol A. | 2013-06-20 |
20130157337 | TEMPLATE-DIRECTED ASSEMBLY OF RECEPTOR SIGNALING COMPLEXES - Transmembrane receptors in the signaling pathways of bacterial chemotaxis systems influence cell motility by forming noncovalent complexes with the cytoplasmic signaling proteins to regulate their activity. The requirements for receptor-mediated activation of CheA, the principal kinase of the | 2013-06-20 |
20130157338 | RHAMM BINDING PEPTIDES - The present invention provides for peptides that bind to Receptor for Hyaluronic Acid Mediated Motility (RHAMM) molecules. More specifically, provided are peptides capable of specifically binding RHAMM molecules and capable of binding RHAMM with substantially high affinity. These novel RHAMM-binding peptides provide the basis for new imaging probes that can be used to identify cells expressing RHAMM, and for methods of imaging, prognosis, diagnosis and treatment of conditions associated with RHAMM expression. | 2013-06-20 |
20130157339 | STABILIZED PROTEASE COMPOSITION - A composition is provided, which comprises a serine protease; a reversible inhibitor of said serine protease; and a stabilizing agent M having the formula I: | 2013-06-20 |
20130157340 | GLYPHOSATE RESISTANT 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE (EPSP) SYNTHASE - A plant comprising SEQ. ID. NO. 2 or a functional portion thereof, wherein SEQ ID NO. 2 is not native to said plant. A glyphosate resistant grass of economic value comprises a nucleic acid molecule that encodes a EPSPS enzyme. In some embodiments, the nucleic acid molecule comprises a sequence of SEQ. ID. NO. 1, or a functional portion thereof. In some embodiments, the EPSPS enzyme can be a polypeptide molecule comprising an amino acid sequence that is essentially of SEQ. ID. NO. 2, or portion thereof. Embodiments include a DNA construct comprising a SEQ. ID. NO. 1 or a functional portion thereof and transgenic methods for inserting the DNA construct into a plant. Some embodiments include non-transgenic glyphosate resistant turfgrasses. | 2013-06-20 |
20130157341 | Multiply-Substituted Protease Variants - Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue equivalent to positions 7, 23, 26, 28, 29, 30, 31, 47, 66, 69, 73, 82, 85, 88, 90, 92, 93, 105, 113, 139, 148, 149, 150, 151, 178, 200, 201, 231, 233, 267 and/or 273 of | 2013-06-20 |
20130157342 | NOVEL ALDOLASE AND PRODUCTION PROCESS OF SUBSTITUTED ALPHA-KETO ACIDS - 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus | 2013-06-20 |
20130157343 | BIOLOGICAL METHODS FOR PREPARING ADIPIC ACID - The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production. | 2013-06-20 |
20130157344 | METHOD FOR PRODUCING OIL-RICH MICROALGAE AS FEEDSTOCK FOR BIODIESEL PRODUCTION - A process for production of oil-rich microalgae is disclosed, which includes methods for cultivating strains of | 2013-06-20 |
20130157345 | STABILIZATION AND ACTIVATION OF PROTEASE FOR USE AT HIGH TEMPERATURE - Methods for use of select organic compounds for the activation and stabilization of thermally labile enzymes, including proteases, are disclosed. The invention further relates to compositions of certain organic compounds with enzymes to enable the use of such enzymes at high temperature conditions, such as for warewash temperatures and conditions. In particular, organic activator-stabilizers including heat-deactivated proteases and zwitterionic materials are combined with enzymes according to the invention. As a result, the invention provides enzyme cleaning efficacy for various high temperature conditions, including warewash applications. | 2013-06-20 |
20130157346 | COMPUTER CONTROLLED IN-VESSEL COMPOSTING PROCESS AND APPARATUS - An in-vessel composting apparatus and process for continuous processing of food waste into an end product comprising a bulk organic compost material. The apparatus comprising a shredder/particle sizer feeding a horizontal drum having at least three chambers with connecting ports of sequentially increasing diameter, and through to a bulk collection container. The apparatus is further equipped with motorized drum rotation and provision for compressing and draining excess fluid from the incoming feed stock and then reintroducing it in the third chamber as needed to maintain suitable moisture level. | 2013-06-20 |
20130157347 | Method of Analyzing Cardiovascular Disorders and Uses Thereof - Compositions, systems, and methods comprising circulating endothelial cells (CECs) are provided. The compositions described herein utilize isolated CECs, including compositions in a form that allows analysis of the CECs. The systems described herein utilize isolated CECs and an analytical tool or an output from an analytical tool. The methods described herein are related to the use of isolated CECs and analytical tools for providing information, to a health care provider or the CEC donor, that is relevant to the cardiovascular health of the CEC donor. Thus, the compositions, systems and methods described herein involve both a transformation (e.g., non-isolated CECs to isolated CECs, or isolated CECs to analyzed CECs) and a machine (e.g., isolation tools and analytical tools). | 2013-06-20 |
20130157348 | DEVICE FOR DETECTING NUCLEIC ACIDS - The invention relates to a device that allows a target nucleic acid to be detected in a homogeneous batch using two different detection formats. The device comprises at least two heatable sample blocks and a reaction cartridge which contains a base ( | 2013-06-20 |
20130157349 | Self-Contained Biological Analysis - Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include nucleic acid amplification and detection and immuno-PCR. | 2013-06-20 |
20130157350 | APPARATUS AND METHOD FOR DETECTING GLYCOL - A method and apparatus are provided for detecting contaminants, such as ethylene glycol and diethylene glycol, in various materials, including household products, and medicines. The contaminants can be detected using enzyme assays that produce measurable changes in light absorption and/or light fluorescence. | 2013-06-20 |
20130157351 | COMPACT WIDE-FIELD FLUORESCENT IMAGING ON A MOBILE DEVICE - Wide-field fluorescent imaging on a mobile device having a camera is accomplished with a compact, light-weight and inexpensive optical components that are mechanically secured to the mobile device in a removable housing. Battery powered light-emitting diodes (LEDs) contained in the housing pump the sample of interest from the side using butt-coupling, where the pump light is guided within the sample holder to uniformly excite the specimen. The fluorescent emission from the sample is then imaged using an additional lens that is positioned adjacent to the existing lens of the mobile device. A color filter is sufficient to create the dark-field background required for fluorescent imaging, without the need for expensive thin-film interference filters. | 2013-06-20 |
20130157352 | Magnetically Coupled System For Mixing - The invention provides a mixing system comprising a magnetically coupled drive system and a foil for cultivating algae, or cyanobacteria, in an open or enclosed vessel. The invention provides effective mixing, low energy usage, low capital expenditure, and ease of drive system component maintenance while maintaining the integrity of a sealed mixing vessel. | 2013-06-20 |
20130157353 | CELL-CULTURE-BAG - A cell-culture-bag for use in the expansion of stem cells from a crude biopsy, comprising: outer walls; a chamber located within the walls; a first inlet, and first and second outlets, providing fluid communication with the chamber, for connection to a perfusion apparatus; and a filter arrangement constructed to allow passage of red blood cells and block passage of stem cells from the first outlet, and block passage of microcarriers from the second outlet. | 2013-06-20 |
20130157354 | TRANSGENIC NON-HUMAN ANIMALS FOR PRODUCING CHIMERIC ANTIBODIES - The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity. | 2013-06-20 |
20130157355 | ROCKABLE BIOCONTAINER - Biocontainers, as well as methods and platforms for rocking the biocontainers, are disclosed. | 2013-06-20 |
20130157356 | METHODS & COMPOSITIONS FOR IMPROVING PROTEIN PRODUCTION - The invention relates to compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures. | 2013-06-20 |
20130157357 | LENTIVIRAL VECTORS FOR THE PREPARATION OF IMMUNOTHERAPEUTICAL COMPOSITIONS - The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector. | 2013-06-20 |
20130157358 | Method for neuroepithelial cells differentiation from pluripotent stem cells and medium using same - The present invention discloses a neural induction medium comprising Wnt-signal agonist, TGFβ-signal inhibitor and FGF-signal agonist for inducing neural differentiation. The neural induction medium used in a culture system is capable for inducing the neural differentiation of stem cells into neuroepithelial cells which are useful for the clinical applications. Therein, the neuroepithelial cells can further differentiate into mature neurons for the practical applications including regeneration medicine and drug discovery for neural disorders. | 2013-06-20 |
20130157359 | FGF HAVING ENHANCED STABILITY - Methods are provided that exploit thermostable FGF-1 proteins for support of human pluripotent stem cell cultures. Also provided are compositions containing thermostable FGF-1 for culturing of human pluripotent stem cells. | 2013-06-20 |
20130157360 | BIOMIMETIC TISSUE SCAFFOLD AND METHODS OF MAKING AND USING SAME - Three-dimensional biomimetic tissue scaffolds, as well as methods of manufacture of these scaffolds. The method is fully customizable to create a biomimetic tissue scaffold with shapes, densities, and geometries similar or identical to the tissue it imitates. For example, physiologically realistic collagen/PEG villi created using the method are designed to have a high-aspect ratio and curvature similar to villi found in the human small intestine. Accordingly, the biomimetic tissue scaffolds serve as an improved in vitro model for a wide variety of physiological research, as well as pharmacological testing and drug, compound, and/or metabolite uptake by cells growing on the scaffold, among many other uses. | 2013-06-20 |
20130157361 | CATALYTIC DOMAINS FROM LYSYL OXIDASE AND LOXL2 - Disclosed herein are amino acid sequences, and encoding nucleotide sequences, of isolated catalytic domains of the LOX and LOXL2 proteins from human and mouse. Methods for the preparation and use of these isolated catalytic domains are also provided. | 2013-06-20 |
20130157362 | METHOD OF LIQUID NITROGEN SURFACE VITRIFICATION - A method of liquid nitrogen surface vitrification requiring an embryo washed in a rinsing medium, then incubated in a base medium and incubated in a hold medium before being washed in a vitrification medium and produced into a vitrification droplet ( | 2013-06-20 |
20130157363 | METHODS OF PRODUCING T CELL POPULATIONS ENRICHED FOR STABLE REGULATORY T-CELLS - The present invention provides methods for producing cell populations enriched for stable, regulatory T cells (Tregs). In particular, the invention relates to methods for culturing T cells such that the final culture is enriched for stable, regulatory T cells. It also relates to methods for stabilizing regulatory T cells. Also provided are compositions enriched for stable, regulatory T cells, which are useful for treating individuals in need of such treatment. The methods and compositions disclosed herein can also be used to treat an individual suffering from an immune-mediated disease. | 2013-06-20 |
20130157364 | MEDIUM COMPOSITION FOR CULTURING SELF-ACTIVATED LYMPHOCYTES AND METHOD FOR CULTURING SELF-ACTIVATED LYMPHOCYTES USING SAME - Disclosed is a medium composition for culturing self-activated lymphocytes, which contains anti-CD3 antibody and anti-CD16 antibody in addition to interleukin 2 (IL-2), interleukin 12 (IL-12) and interleukin 18 (IL-18) in a medium, and thus can efficiently proliferate and activate NK cells, T cells and NKT cells and, at the same time, can significantly increase the ratio of NK cells in lymphocytes so as to provide immunocytes having excellent effects on the treatment of various kinds of malignant tumors, and a method for culturing self-activated lymphocytes using the medium composition. | 2013-06-20 |
20130157365 | INDUCED PLURIPOTENT STEM CELLS FROM HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS - We have disclosed an induced pluripotent stem cell and the method of preparing the induced pluripotent stem cell from a human umbilical cord tissue-derived cell. More particularly, we have disclosed a human umbilical cord tissue-derived iPS cell which may be differentiated into cells of ectoderm, mesoderm, and endoderm lineages. | 2013-06-20 |