25th week of 2009 patent applcation highlights part 50 |
Patent application number | Title | Published |
20090156389 | METHOD OF THE PREPARATION OF MICROPOROUS CRYSTALLINE MOLECULAR SIEVE POSSESSING MESOPOROUS FRAMEWORKS - The present invention relates to a method of preparing a microporous crystalline molecular sieve Inorganic gel having mesoporous skeleton, comprising following steps: (a) adding a meso-SDA (meso-Structure Directing Agent) into a gel composition of synthesizing molecular sieve, (b) subjecting the mixture obtained in the above step (a) to crystallization by a hydrothermal reaction, a microwave reaction, a dry-gel synthesis, etc., and (c) removing selectively organic materials from the resulted material obtained in the above step (b) by a calcination or a chemical treatment. Molecular sieve having mesoporous skeleton synthesized by the present invention exhibits, as compared with conventional zeolite, a good molecule diffusion ability and a greatly improved catalytic activity. | 2009-06-18 |
20090156390 | Noble metal particle and process of producing the same - The present invention provides a noble metal particle with an improved methanol-oxidation property. This noble metal particle has a platinum particle and ruthenium particles deposited on only part of the surface of the platinum particle. This noble metal particle suitably can be produced by precipitating the ruthenium particles out of the solution so that the ruthenium particles are deposited on only part of the surface of the platinum particle by further adding a ruthenium salt into the solution and reducing the ruthenium salt after the reduction of the platinum salt in the solution essentially is completed. This noble metal particle is suitable as a catalyst to be supported on an electrode of a polymer electrolyte fuel cell typified by a direct methanol fuel cell. | 2009-06-18 |
20090156391 | Catalyst Components for the Polymerization of Olefins - A catalyst component for the polymerization of olefins CH | 2009-06-18 |
20090156392 | CATALYST COMPOSITIONS AND METHODS FOR ALCOHOL PRODUCTION FROM SYNTHESIS GAS - In one aspect of this invention, catalytic compositions produced by calcining intermediates of the formula [NR | 2009-06-18 |
20090156393 | CATALYST COMPOSITIONS AND METHODS FOR ALCOHOL PRODUCTION FROM SYNTHESIS GAS - In one aspect of this invention, catalytic compositions produced by calcining intermediates of the formula [NR | 2009-06-18 |
20090156394 | INORGANIC SINTERED MATERIAL CONTAINING PHOTOCATALYST COVERED WITH SILICON OXIDE FILM - The present invention is to provide an inorganic sintered material that excels in photocatalytic activity as compared with that exhibited in the use of a photocatalyst of titanium oxide only. | 2009-06-18 |
20090156395 | Method for Preparing Metal Oxide Containing Precious Metals - The present invention relates to a method for preparing a metal oxide containing precious metals, which can be used for a catalyst for purifying automobile exhaust gases and has excellent heat resistance and, more particularly, to a method for preparing a metal oxide containing precious metals including the step of continuously reacting a reaction mixture, including (i) water, (ii) a water-soluble precious metal compound, (iii) a water-soluble cerium compound and (iv) at least one water-soluble metal compound selected from the group consisting of a zirconium compound, a scandium compound, a yttrium compound and a lanthanide metal compound other than a cerium compound, at a temperature from 2000 C to 700° C. and at a pressure from 180 bar to 550 bar, wherein the molar ratio of precious metal to metal other than the precious metal in a reaction product is in the range from 0.001 to 0.1. | 2009-06-18 |
20090156396 | Exhaust Gas Purifying Catalyst and Method for Manufacturing the Same - An exhaust gas purifying catalyst has a front end high concentration coating area coated with a precious metal of a high concentration, and a rear end complex coating area coated at different precious metal densities according to the flowing amount of the exhaust gas and a method for manufacturing an exhaust gas purifying catalyst, which is capable of simultaneously coating a rear end complex coating area at different precious metal densities according to the flowing amount of the exhaust gas. The exhaust gas purifying catalyst includes a front end high concentration coating area coated with a precious metal of a high concentration and a rear end complex coating area having at least two areas of different coating densities on the rear side of the front end high concentration coating area. | 2009-06-18 |
20090156397 | INKS FOR USE ON OPTICAL RECORDING MEDIA - An optical recording medium, comprises a substrate, an imaging composition disposed on said substrate, said compound comprising: a matrix, a color-forming agent, and a nucleating agent. The nucleating agent increases the nucleation density of at least one component of the color-forming agent. | 2009-06-18 |
20090156398 | Fungicidal 5-alkyl-6-phenylpyrazolopyrimidin-7-ylamines - 5-Alkyl-6-phenylpyrazolopyrimidin-7-ylamines of the formula (I) in which the substituents are defined as in the description, processes for preparing these compounds, compositions comprising them, and their use for controlling phytopathogenic fungi. | 2009-06-18 |
20090156399 | Synergistic Insecticide Mixtures - The invention relates to insecticidal mixtures comprising novaluron and at least one further known active compound from the group of the neonicotinoids, and to the use of these mixtures for controlling animal pests. | 2009-06-18 |
20090156400 | HERBICIDE COMBINATIONS COMPRISING SPECIFIC SULFONYLUREAS - Herbicide combinations comprising an effective amount of components (A) and (B) have improved herbicidal action wherein (A) is one or more herbicides of the formula (I) or salts thereof | 2009-06-18 |
20090156401 | Herbicidal Composition - The present invention provides a method for post-emergence selective weed control in turf sites by applying an herbicidal composition comprising sulfentrazone and quinclorac to a locus where weeds are present. | 2009-06-18 |
20090156402 | 4-ALKOXY-CYCLOHEXANE-1-AMINO-CARBOXYLIC ESTERS AND PROCESSES FOR THEIR PREPARATION - The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) | 2009-06-18 |
20090156403 | TURF MOLD REMEDIATION - A method for treating diseased plants, such as turf, includes mixing a quantity of a plant remediation composition with water and applying the plant remediation composition to the diseased plants. The plant remediation composition may include from about 30 to about 50 volume percent of a potassium silicate, from about 0.25 to about 2.0 volume percent of a surfactant, from about 0.25 to about 2.0 volume percent of a polyol, and from about 46 to about 69.5 volume percent water. The plant remediation composition may be used to treat plant molds and fungi, such as Anthracnose, Fairy Ring, Brown Patch, Dollar Spot, and Snow Mold. | 2009-06-18 |
20090156404 | Methods and Compositions for Reducing Stress in Plants - The present application is directed to methods and compositions for improving growth or yield of plants by reducing stress from abiotic factors without adversely affecting photosynthesis. In one embodiment, the compositions include particulate material and one or more plant growth regulating compounds such as non-gaseous plant hormones, amino acids and amino acid derivatives, and terpenes, and mixtures thereof. The composition is applied to at least part of the surface of the plant, forming a film on the plant. The effects of abiotic factors such as heat, cold, light, and water stress may be reduced or eliminated after application of the composition, and growth or yield may be increased while photosynthesis is not adversely affected. | 2009-06-18 |
20090156405 | Method of Use of a Synergistic Composition - This invention relates to a synergistic composition made of a herbicidally effective amount of a propanil-based product, such as SUPER WHAM® and the at least one ACCase inhibitor herbicide such as CLINCHER® in an amount sufficient to facilitate the herbicidal activity of the propanil-based herbicide. It has been found that this synergistic composition, when applied to a field of rice, allows a reduction in the amount of herbicide needed, greater flexibility in timing of the application and broad spectrum of weed control. | 2009-06-18 |
20090156406 | Polymer Composite Film With Biocide Functionality - Polymer composite material with biocide functionality, preferably for the use in agriculture, comprising at least one base polymer compound and at least one biocide active ingredient, wherein the biocide active ingredient is an organic biocide that can be emitted from the polymer composite material by diffusion and/or osmosis and method of its production. | 2009-06-18 |
20090156407 | Pesticide Preparations Comprising Copolymers - The invention relates to pesticide preparations comprising copolymers obtainable by copolymerization of
| 2009-06-18 |
20090156408 | HIGH TEMPERATURE SUPERCONDUCTING DIELECTRIC CERAMIC INSULATION - High-temperature superconductive devices and assemblies are provided. According to one embodiment, a high-temperature superconductive device includes a superconducting substrate and a dielectric ceramic insulator. The superconducting substrate comprises a superconducting material having superconductive properties above about 60 K. The dielectric ceramic insulator is applied to the superconducting substrate. The dielectric ceramic insulator comprises a thermal conductivity of at least about 0.2 W/cm-K at a temperature ranging from about 60 K to about 90 K and has a grain size of at least about 2 microns. Additional embodiments are disclosed and claimed. | 2009-06-18 |
20090156409 | FAULT CURRENT LIMITER INCORPORATING A SUPERCONDUCTING ARTICLE - A fault current limiter (FCL) article is disclosed including a superconducting tape segment that includes a substrate, a buffer layer overlying the substrate, and a high temperature superconducting (HTS) layer overlying the buffer layer, wherein the superconducting tape segment forms a meandering path that is continuous having a plurality of windings. The article also includes a shunting circuit electrically connected to the superconducting tape segment. | 2009-06-18 |
20090156410 | Fabrication Method of a MgB2 Superconducting Tape and Wire - In a fabrication method of a MgB | 2009-06-18 |
20090156411 | Method of Producing Superconductive Oxide Material - There is provided a method of efficiently producing a superconductive material more excellent in properties, and large in area when executing thermal decomposition of a metalorganic compound, and formation of a superconductive material with heat treatment. The method of producing a superconductive material comprising the step (1) of applying a solution of an organic compound of metals, oxides of the metals forming a superconductive material, onto a support body to be subsequently dried, the provisional baking step (2) of causing organic components of the organic compound of the metals to undergo thermal decomposition, and the main baking process step (3) of causing transformation of the oxides of the metals into the superconductive material, thereby producing an epitaxially-grown superconductive coating material, wherein the support body is irradiated with the laser light during a period between the steps (1) and (2) from a surface of the support body, on the opposite side of the surface coated with the solution of the organic compound of the metals for forming the superconductive material. | 2009-06-18 |
20090156412 | SURFACE-CAPTURE OF TARGET NUCLEIC ACIDS - The disclosure provides methods of capturing target nucleic acids (e.g., gene or gene fragments) onto a solid support for further analysis. The disclosed methods utilize a capture probe that selectively circularizes only the target nucleic acid. Following the circularization of the target, the linear, non-target, nucleic acids are removed from the sample. Next, the circularized target is linearized and bound to a solid support. To allow for linearization, the capture probe may include a cleavage site that can be a noncanonical nucleotide(s) (e.g., uracil in DNA) and/or a rare-cutter site (e.g., the Not I restriction site). In some embodiments, the target nucleic acid is captured onto a support without an intermediate amplification step. | 2009-06-18 |
20090156413 | Method, system, apparatus and device for discovering and preparing chemical compounds for medical and other uses - Disclosed in this invention are methods, systems, databases, user-interfaces, software, media, and services useful for evaluating interactions between chemical compounds and proteins and for utilizing the information resulting from such evaluation for the purpose of discovering chemical compounds for medical and other fields. An approach termed “reverse proteomics” is disclosed. This invention generates an enormously large pool of new target proteins for drug discovery, novel methods for designing of new drugs, and a previously unthinkable pool of virtually synthesized small molecules for therapeutic uses. This invention is also applicable, for example, to discovery of substitutes for environmentally hazardous chemicals, more effective agrochemicals, and healthier food additives. | 2009-06-18 |
20090156414 | Genetic Analysis in Racing Animals - The invention relates to products and processes for determining or predicting sporting performance, ability or aptitude of horses and other performance animals through the study of nucleotide sequence variants, genetic types or profiles, in particular the study of mitochondrial sequence variants. The invention is useful in the horseracing industry. | 2009-06-18 |
20090156415 | REAL-TIME PCR OF TARGETS ON A MICRO-ARRAY - The present invention relates to a method and apparatus for monitoring on a micro-array a PCR amplification of a nucleotide molecule being present in a solution. The method includes the steps of: providing a support having fixed upon its surface a microarray having at least a capture molecule being immobilized in specifically localized areas of the support and a reaction chamber; introducing a solution containing the nucleotide molecule into the reaction chamber and reagents for nucleotide molecule amplification and labelling; submitting the solution to at least 2 thermal cycles having at least 2 and preferably 3 different temperature steps in order to obtain labelled target nucleotide molecule by PCR amplification; performing at least a measurement of the labelled target nucleotide molecule in at least one thermal cycle by incubating the labelled target nucleotide molecule under conditions allowing a specific binding between the target nucleotide molecule and its corresponding capture molecule and measuring the light emission from the bound labelled target nucleotide molecule in response to excitation light with the solution being present in the chamber and containing the labelled target nucleotide molecule. The surface of emission for a localized area is between about 0.1 μm | 2009-06-18 |
20090156416 | Hybrid Molecular Probe - A system and method for analyzing a substance, in particular RNA in vivo, comprising a hybrid molecular probe, said probe comprising two single-stranded nucleic acid sequences tethered together with a polyethylene glycol polymer and fluorophores attached to either end of the sequences. When a probe of the invention hybridizes to a target substance (such as a target RKA sequence), fluorescence resonance energy transfer occurs between the two fluorophores to generate a visible signal. | 2009-06-18 |
20090156417 | Library From Toxin Mutants, And Methods Of Using Same - This application relates to libraries of ABx toxin mutants, in which a peptide insert is introduced into the protease-sensitive loop of the A-chain sequence to alter the type of cells to which toxic species are delivered. Said libraries are used in the development of therapeutics targeted against specific cell types. | 2009-06-18 |
20090156418 | MARKERS AND METHODS FOR ASSESSING AND TREATING CROHN'S DISEASE AND RELATED DISORDERS - A method for assessment of the suitability of and/or effectiveness of a target therapy for a gastrointestinal-related disorder, such as Crohn's disease, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes in a 10-member gene panel in a sample. The method enables identification of the effectiveness of target therapies prior to or after starting a patient on such therapies. | 2009-06-18 |
20090156419 | HYBRIDIZATION METHODS USING NATURAL BASE MISMATCHES - The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions. | 2009-06-18 |
20090156420 | Method for detecting cancer - To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer. | 2009-06-18 |
20090156421 | ASSAYS AND METHODS FOR EVALUATING MULTIMERIC COMPLEXES - Assays, e.g., homogenous assays, and methods for identifying, quantifying and/or monitoring the formation and/or stability of a multimeric complex, e.g., a ternary complex are disclosed. The methods and assays of the invention can be used to identify and/or evaluate agents (e.g., proteins, peptides, antibody molecules, and small and large molecules) that interfere with and/or inhibit the formation of a multimeric complex (e.g., a ternary complex) or that disrupt a previously formed complex. | 2009-06-18 |
20090156422 | DEVICE AND METHOD TO DETECT ANALYTES - The present invention relates to a device for and method of detecting analytes in samples, using optimized concentrations of Fc receptor-antibody complexes being immobilized on solid supports. | 2009-06-18 |
20090156423 | METHOD AND DEVICE FOR INTEGRATED SYNTHESIS AND ANALYSIS OF ANALYTES ON A SUPPORT - Methods and devices provide integrated synthesis of a support for analyte determination and the analyte determination. Preferred embodiments involve particles immobilized on the surface of a support to which receptors are coupled location-specifically, time-specifically or both on pre-determined positions on the support. | 2009-06-18 |
20090156424 | USE OF MASS LABELED PROBES TO DETECT TARGET NUCLEIC ACIDS USING MASS SPECTROMETRY - The invention relates to the use of mass labeled probes to characterise nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid in a sample, using a circularising probe in which a mass tag is present in the probe. Further methods of detecting the presence of a target nucleic acid are provided, which in contrast use a probe detection sequence in the circularising probe, wherein the probe detection sequence is detected with a probe attached to a mass tag. Methods for determining a genetic profile from the genome of an organism also form part of the invention. | 2009-06-18 |
20090156425 | METHODS FOR DETECTING TARGET ANALYTES AND ENZYMATIC REACTIONS - A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents. | 2009-06-18 |
20090156426 | FUNCTIONALIZED POROUS SUPPORTS FOR MICROARRAYS - The present invention relates to functionalized porous carriers which comprise a material having at least one porous surface, nanoparticles having molecule-specific recognition sites being present in the pores of the material surface, and to a process for producing functionalized porous carriers. The invention further relates to functional elements produced using the functionalized carriers, such as microtiter plates, microarrays and flow devices, and also to uses of the functionalized carriers and functional elements. | 2009-06-18 |
20090156427 | Bio-Sensing Nanodevice - The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor. | 2009-06-18 |
20090156428 | MULTI-MODE MICROARRAY APPARATUS AND METHOD FOR CONCURRENT AND SEQUENTIAL BIOLOGICAL ASSAYS - A multi-mode, multiplexed array of probe elements of various forms attached to a common support and methods of using the array are disclosed. The array is used for the concurrent and/or sequential detection of combinations of more than one chemical and/or biological material, such as: target nucleic acid sequences, genomic DNA, pcr products, RNA (including microRNA), single nucleotide polymorphisms, proteins, peptides, carbohydrates, polysaccharides, phosphorylation or methylation state of target molecules, chromosomal abnormalities, and other biomolecules, moieties, metals, or chemical compounds in a biological sample. The method of the invention includes the deposition and/or in-situ synthesis of the various probe elements which comprise the array or group of arrays, the preparation and delivery of the target biological sample in forms suitable for concurrent and/or sequential detection, the hybridization methods of target to probe, the detection methods for target-probe interactions, and the use of such arrays in automated systems for research or diagnostic applications. | 2009-06-18 |
20090156429 | PULSED-MULTILINE EXCITATION FOR COLOR-BLIND FLUORESCENCE DETECTION - The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population. | 2009-06-18 |
20090156430 | PROMOTER AND PLASMID SYSTEM FOR GENETIC ENGINEERING - This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful for genetic engineering in microorganisms, especially where multiple genetic insertions are sought. | 2009-06-18 |
20090156431 | Methods for Nucleic Acid Mapping and Identification of Fine Structural Variations in Nucleic Acids - An in vitro, extracellular method of juxtaposing sequence tags (GVTs) where two constituent members of a tag pair (GVT-pair) are unique positional markers of a defined separation distance and/or are markers of nucleic acid positions that demarcate adjacent cleavage sites for one or more different restriction endonucleases along the length of a plurality of target nucleic acid molecules, the method comprising: Fragmenting the target nucleic acid molecule to form target DNA insert; ligating a DNA adaptor having one or more restriction endonuclease recognition sites to both ends of a fragmented target DNA insert and the ligation of the adaptor-ligated target DNA insert to a DNA backbone to create a circular molecule; digesting the adaptor using a restriction endonuclease at the recognition site to cleave the target DNA insert at a defined distance from each end thereof to create two sequence tags (GVTs) comprising terminal sequences of the target DNA insert that are attached to the linear DNA backbone; and recircularizing the linear DNA backbone with the attached GVTs to obtain a circular DNA molecule including a GVT pair having two juxtaposed GVTs; GVT-pair DNA is recovered by nucleic acid amplification. | 2009-06-18 |
20090156432 | Corrosion inhibitor intensifier compositions and associated methods - Of the many methods and compositions provided herein, one method includes a method comprising contacting a metal surface with an acidic fluid comprising an aqueous base-fluid, an acid, a corrosion inhibitor, and a corrosion inhibitor intensifier composition comprising a compound that corresponds to a formula R | 2009-06-18 |
20090156433 | HF acidizing compositions and methods for improved placement in a subterranean formation to remediate formation damage - According to the invention, a fully viscosified acid diversion system for hydrofluoric acid has been developed. The viscosifying agent comprises a xanthan polymer or a derivative thereof. A method of acidizing a portion of a subterranean formation is provided, the method comprising the steps of: (A) forming a viscosified treatment fluid comprising: (i) water; (ii) hydrogen fluoride or a controlled-release source of hydrogen fluoride; and (iii) a gelling agent comprising a xanthan polymer or derivative thereof; and (B) introducing the viscosified treatment fluid into the portion of the subterranean formation. A breaking agent can be used to achieve a controlled gel break time under downhole conditions. Other additives can also be included in the treatment fluid. A composition for use in treating a subterranean formation is also provided, the composition comprising: (A) water; (B) hydrogen fluoride or a controlled-release source of hydrogen fluoride; and (C) a gelling agent that comprises a xanthan or derivative thereof. | 2009-06-18 |
20090156434 | Process to prepare borozirconate solution and use as cross-linker in hydraulic fracturing fluids - A process to prepare a stable solution of a borozirconate complex is disclosed and use of the solution in oil field applications such as hydraulic fracturing and plugging of permeable zones. The process comprises contacting zirconium complex with a first alkanolamine, then glycerol and water, then with a solution of a boron compound and a second alkanolamine. The solution is particularly suitable for use in a cross-linking composition at temperatures of 275° F. (135° C.) and higher in the subterranean formation. | 2009-06-18 |
20090156435 | Defoaming Methods and Compositions - Embodiments of the present invention are directed to defoaming methods and compositions for well treatment fluids. An exemplary embodiment of the present invention provides a method of defoaming a well treatment fluid, comprising combining a defoaming composition with the well treatment fluid, wherein the defoaming composition comprises an amide of a carboxylic acid, a polypropylene glycol, an ethoxylated and propoxylated fatty alcohol, an ethoxylated alcohol comprising from 3 carbons to 6 carbons, and a hydrophobic silica in an amount of up to about 3% by weight of the defoaming composition. | 2009-06-18 |
20090156436 | Spacer Fluid Additive - A spacer fluid comprises a fluid and a viscosity agent. The viscosity agent is a mixture of at least two polyvinylalcohol compositions. A first polyvinylalcohol composition comprises polyvinylalcohols having a first degree of hydrolysis and a second polyvinylalcohol composition comprises polyvinylalcohols having a second degree of hydrolysis. The first and second degrees of hydrolysis are substantially different such that the rheology of the spacer fluid is stable during temperatures changes. | 2009-06-18 |
20090156437 | DOUBLE-LAYER LUBRICATION COATING COMPOSITION, DOUBLE-LAYER LUBRICATION COATING AND PISTON HAVING SAME COATING - A double-layer lubrication coating composition is made up of an upper-layer coating composition and a lower-layer coating composition. The upper-layer coating composition is made up of 50 to 70 wt % of an epoxy resin or a polyamide-imide resin, 5 to 20 wt % of boron nitride, and 15 to 30 wt % of silicone nitride or alumina. The lower-layer coating composition is made up of 50 to 70 wt % of an epoxy resin or a polyamide-imide resin, 15 to 30 wt % of polytetrafluoroethylene and 5 to 20 wt % of molybdenum disulfide and may include graphite as required. | 2009-06-18 |
20090156438 | Engine Lubricant for Improved Fuel Economy - A lubricant composition comprising an oil of lubricating viscosity, an amino-functionalized acrylic or methacrylic-containing polymer, comprising about 2 percent to about 8 percent by weight of an amine moiety bearing a tertiary amino group, attached to said polymer through an ester, amide, or imide linkage; and a nitrogen-containing dispersant, provides reduced friction to an internal combustion engine and improved fuel economy. | 2009-06-18 |
20090156439 | LUBRICANT COMPOSITIONS COMPRISING COLLOIDAL DISPERSIONS OF IRON AND TREATMENT OF ENGINE EXHAUST GASES THEREWITH - Lubricant compositions contain a blend of a lubricating oil and a colloidal dispersion of particles of at least one iron compound and an amphiphilic agent; such compositions are useful for operating an engine, more particularly a diesel engine, which is equipped with an exhaust system fitted with a particle filter, wherein the particles present in the exhaust gases are trapped on the filter and, periodically, the trapped particles are burned, and further wherein the subject compositions are employed as engine lubricants with a view to catalyzing the combustion of the trapped particles. | 2009-06-18 |
20090156440 | Trunk piston engine lubricating oil compositions - This invention encompasses trunk piston engine lubricating oil compositions, comprising a major amount of one or more Group I base oils; and one or more dispersant additives, wherein the concentration of the one or more dispersant additives within the trunk piston engine lubricating oil composition is about 0.2-0.6 wt. % on an actives basis; and methods for making and using the trunk piston engine lubricating oil compositions. | 2009-06-18 |
20090156441 | Cycloalkyl phenylenediamines as deposit control agents for lubricants - The invention is a C | 2009-06-18 |
20090156442 | Lubricant Compositions With Low HTHS for a Given SAE Viscosity Grade - A lubricant composition that exhibits low high temperature high shear viscosity is disclosed. The lubricant composition is made up of a first polymer having a kinematic viscosity ratio less than or equal to 0.25 and a shear stability index (SSI) equal to or greater than 20 percent and base oil having a viscosity index equal to or greater than 120. | 2009-06-18 |
20090156443 | ORGANIC MOLYBDENUM ADDITIVE, ITS PREPARATION METHOD, A LUBRICATING COMPOSITION CONTAINING SAID ADDITIVE, AND USE OF THE SAME - The present invention relates to an organic molybdenum additive and its preparation method, and a lubricating composition comprising said additive, and use of said additive and its lubricating composition in the aspect of improving antiwear and antifriction property of oil products. The organic molybdenum additive according to the present invention is characterized in that it is prepared by reacting several kinds of feedstock as follows: a polylol ester of p-hydroxybenzene alkyl acid, an inorganic molybdenum compound and an aliphatic amine and/or an aromatic amine and/or an amide. The organic molybdenum additive of the present invention has excellent antiwear and/or antifriction property. | 2009-06-18 |
20090156444 | ADDITIVE COMPOSITION FOR EP GREASES WITH EXCELLENT ANTIWEAR AND CORROSION PROPERTIES - A lubricant composition is provided as follows: | 2009-06-18 |
20090156445 | LUBRICANT COMPOSITION SUITABLE FOR ENGINES FUELED BY ALTERNATE FUELS - A lubricant composition suitable for use in engines fueled by gasoline or biorenewable fuels or both, comprising an oil of lubricating viscosity and a dispersant system is disclosed herein. Also disclosed is an emulsion composition comprising a biorenewable fuel, an oil of lubricant viscosity, and a dispersant system. A method of reducing aqueous separation in an emulsion composition is also disclosed. | 2009-06-18 |
20090156446 | Corrosion Inhibition - The present invention provides a lubricating composition containing (a) an oil of lubricating viscosity; (b) a corrosion inhibitor; and (c) an antiwear agent comprising at least one of (i) polyhydric alcohol with oxyalkylene groups, (ii) a fatty amine, or (iii) mixtures thereof, wherein the lubricating composition has a total sulphated ash content of less than 0.8 wt %. The invention further provides for the use of the lubricating composition in an internal combustion engine. | 2009-06-18 |
20090156447 | LUBRICANT FOR THREAD ROLLING AND THREAD ROLLING METHOD - A thread rolling lubricant of a nonchlorine species, in which a lubricant base oil is blended with 25 through 35 weight % of (A) a sulfur species extreme pressure agent, 6 through 16 weight % of (B) an organic zinc compound, 2 through 12 weight % of (C) a calcium species additive, and 2 through 13 weight % of (D) an oiliness agent for carrying out thread rolling. | 2009-06-18 |
20090156448 | Additive Compositions - Compositions in the form of lubricating oil compositions, greases, fuels or functional fluids containing, in the form of Michael adducts, N-substituted phenylenediamine additives in which at least one of the substituents on the N atoms carries a carbonyl group that is connected to an alkyl, alkoxyalkyl, or alkylthioalkyl group either directly or via an oxygen atom. | 2009-06-18 |
20090156449 | ALKYLATED 1,3-BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME - An alkylated 1,3-benzenediamine compound used as a deposit-control lubricant additives for organic materials including lubricating oil, gasoline, and diesel fuels. The invention improves the oxidative stability of the lubricants and fuels by adding the alkylated 1,3-benzenediamine compound. The alkylated 1,3-benzenediamine compound is formed using a catalytic hydrogenation that alkylates the 4 and/or 6 position of the central aromatic ring. | 2009-06-18 |
20090156450 | FATTY ACYL ISETHIONATE PRODUCT-CONTAINING LIQUID CLEANSING COMPOSITIONS STABILIZED WITH MIXTURE OF LONG CHAIN AND SHORT CHAIN FATTY ACIDS/FATTY SOAPS - The invention provides personal care or hair liquid cleansing compositions comprising fatty acyl isethionate products having more than 5% by wt. free fatty acid/fatty soaps which are stabilized using specific mixture of long chain and short chain fatty acids/fatty soaps; as well as by using proper ratio of total linear fatty acid/fatty soap to total synthetic surfactants (the total synthetic is the sum of (1) fatty acyl surfactant component of (a)—that is, the “pure” fatty acyl isethionate which does not include free fatty acids and/or fatty acid soaps in the fatty acyl surfactant “product”—and (2) the synthetic co-surfactant of (b)). | 2009-06-18 |
20090156451 | SINGLE USE MULTI-PHASE CARE SYSTEM - A convenient single use multi-phase care system including multiple formulations can be packaged in one dispensing unit. The multi-phase care system is capable of separately dispensing one of the multiple formulations at a time in a sequential order to allow the consumer to dispense a daily care regimen one step at a time. In one embodiment, the daily care regimen is a multi-phase skin care system. In another embodiment, the daily care regimen is a multi-phase hair care system. | 2009-06-18 |
20090156452 | MATERIALS FOR PARTICLE REMOVAL BY SINGLE-PHASE AND TWO-PHASE MEDIA - The embodiments of the present invention provide improved materials for cleaning patterned substrates with fine features. The cleaning materials have advantages in cleaning patterned substrates with fine features without substantially damaging the features. The cleaning materials are fluid, either in liquid phase, or in liquid/gas phase, and deform around device features; therefore, the cleaning materials do not substantially damage the device features or reduce damage all together. The cleaning materials containing polymers of a polymeric compound with large molecular weight capture the contaminants on the substrate. In addition, the cleaning materials entrap the contaminants and do not return the contaminants to the substrate surface. The polymers of one or more polymeric compounds with large molecular weight form long polymer chains, which can also be cross-linked to form a network (or polymeric network). The long polymer chains and/or polymer network show superior capabilities of capturing and entrapping contaminants, in comparison to conventional cleaning materials. | 2009-06-18 |
20090156453 | Non-aqueous, non-corrosive microelectronic cleaning compositions containing polymeric corrosion inhibitors - Photoresist strippers and cleaning compositions of this invention are provided by non-aqueous cleaning compositions that are essentially non-corrosive toward copper as well as aluminum and that comprise at least one polar organic solvent, at least one hydroxylated organic amine, and at least one corrosion inhibitor polymer having multiple hydroxyl- or amino-functional groups pendant from the polymer backbone. | 2009-06-18 |
20090156454 | GRANULATES FOR A SENSITIVE WASHING- OR CLEANING AGENT CONTAINING MATERIAL - Granulates for washing- or cleaning agents, containing (a) a sensitive washing- or cleaning agent component, (b) an adsorbent carrier material, (c) a binder that is different from (b), and (d) optional additional substances that are different from (b) and (c). The granulates display a disintegration index of at least 50 percent after 24 hours. These granulates are particularly suited for use in liquid- or gel-forming aqueous washing- or cleaning agents. Also, a procedure for the manufacture of such granulates, in regards to washing- or cleaning agents. | 2009-06-18 |
20090156455 | Compositions With Durable Pearlescent Aesthetics - The present invention relates to liquid compositions provided with durable pearlescent appearance, and to a process of producing said compositions. | 2009-06-18 |
20090156456 | Organoleptic Compounds - The present invention is directed to the fragrance compounds and their intermediates and a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount | 2009-06-18 |
20090156457 | METHODS AND MEANS FOR SCREENING FOR RHOMBOID ACTIVITY - This invention relates to methods of screening for rhomboid modulating compounds using a substrate polypeptide has a core domain comprising a rhomboid cleavable TMD sequence linked to an upstream tag sequence. The core domain sequence is not susceptible to cleavage by non-rhomboid proteases so products of rhomboid dependent proteolysis products may be detected by determining the presence of the tag sequence. Rhomboid modulating compounds identified by the present methods may be useful in a range of therapeutic applications. | 2009-06-18 |
20090156458 | ASSAY FOR THE DETECTION OF FACTORS THAT MODULATE THE EXPRESSION OF INAGP - A reporter construct contains mammalian INGAP 5′-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5′-regulatory region or a fragment thereof. | 2009-06-18 |
20090156459 | Cationic-Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same - The present invention relates to a biocompatible cationic-core carrier composition that has sustained release capability and includes a polymeric backbone, protective chains, poly-cationic moieties and optionally an anionic load molecule. | 2009-06-18 |
20090156460 | CATIONIC BETAINE PRECURSORS TO ZWITTERIONIC BETAINES HAVING CONTROLLED BIOLOGICAL PROPERTIES - Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems. | 2009-06-18 |
20090156461 | Novel Bacillus Thuringiensis Gene with Lepidopteran Activity - The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of | 2009-06-18 |
20090156462 | USE OF FIBROUS TISSUE INDUCING PROTEINS FOR HERNIA REPAIR - The present disclosure relates to hernia repair and methods for stimulating growth of fascia tissue employing compositions comprising fibrous tissue inducing proteins. | 2009-06-18 |
20090156463 | Photokinetic delivery of biologically active substances using pulsed incoherent light - The invention relates generally to transdermal and transmembrane delivery of biologically active substances through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transdermal and transmembrane delivery of biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods. | 2009-06-18 |
20090156464 | Pharmaceutical Compositions and Methods for Insulin Treatment - Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed. | 2009-06-18 |
20090156465 | DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS - The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome. | 2009-06-18 |
20090156466 | Characterization of a MEKK binding site and uses thereof - The present invention provides binding motifs, binding sites, peptides, and 14-3-3/MEKK complexes. Also provided are agents reactive with same, pharmaceutical compositions, molecules, and kits comprising same, and methods of producing same. The present invention further provides isolated nucleic acids and constructs comprising same, host cells comprising the constructs, and transgenic non-human animals. Additionally, the present invention provides methods of: (a) facilitating or inhibiting 14-3-3/MEKK interaction, (b) regulating MEKK activity, (c) identifying agents that interact with MEKK or 14-3-3, (d) detecting and monitoring the development of MEKK-mediated conditions, and (e) treating and/or preventing MEKK-mediated conditions. | 2009-06-18 |
20090156467 | Thymic stromal lymphpoietin promoter and use therefor - A promoter comprising the isolated promoter region of the human Thymic Stromal Lymphopoietin (TSLP) gene and functional portions of the promoter region having TSLP promoter activity. The promoters are useful for identifying promoter agonists and antagonists that can be used to prevent or treat allergic conditions and autoimmune diseases. | 2009-06-18 |
20090156468 | Use of human chorionic gonadotropin oral or injectable for metabolic syndrome treatment - To be used as a therapy for patients with one or more of the following clinical symptoms or laboratory findings: high blood pressure, diabetes type 2, reactive hyperglycemia, plasmatic hypertriglyceridemia, hypercholesterolemia and gout as part of the metabolic syndrome. | 2009-06-18 |
20090156469 | METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF IN TREATING WALDENSTROM'S MACROGLOBULINEMIA - Disclosed are methods of treating Waldenstrom's Macroglobulinemia comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula I. | 2009-06-18 |
20090156470 | INTERFERING RNA DELIVERY SYSTEM AND USES THEREOF - The invention provides a delivery system comprising a cell penetrating peptide, a polyarginine peptide, and an interfering RNA molecule. The system can be used for delivering interfering RNA molecules into a cell in vivo or in vitro. Therapeutic uses for the delivery system are also provided. | 2009-06-18 |
20090156471 | Use of anti-amyloid agents for treating and typing pathogen infections - A method of preventing or treating a pathogen infection in a subject is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an anti amyloid agent, thereby treating or preventing the pathogen infection in the subject. | 2009-06-18 |
20090156472 | Cyclic Depsipeptides - The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase. | 2009-06-18 |
20090156473 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF VIRAL INFECTIONS AND/OR TUMOR DISEASES BY INHIBITING PROTEIN FOLDING AND PROTEIN BREAKDOWN - The invention relates to the treatment of viral diseases with at least one proteasome inhibitor and one inhibitor of protein-folding enzymes. | 2009-06-18 |
20090156474 | Methods for treating obesity and obesity related diseases and disorders - Methods for treating obesity or obesity related disorders are disclosed. These methods include the use of anti-obesity agents directed to the forebrain in combination with anti-obesity agents directed to the hindbrain. | 2009-06-18 |
20090156475 | Gene defects and mutant ALK kinase in human solid tumors - In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 2009-06-18 |
20090156476 | Dimeric or Multimeric Microproteins - Disclosed is a polypeptide comprising at least two microproteins, which preferably comprise an amino acid sequence having a specific binding activity to a target protein. Furthermore, disclosed are polynucleotides encoding such a polypeptide as well as pharmaceutical compositions and kits comprising said polypeptide or polynucleotide. Also disclosed herein are methods of treatments and second medical uses applying the disclosed polypeptide or polynucleotide. Additionally, the disclosure of the present application relates to a method for forming a covalent bond in a microprotein which can be used for producing the disclosed polypeptides. | 2009-06-18 |
20090156477 | Compositions and Methods for Regulating Inflammatory Responses - This invention relates, in part, to compositions and methods for the regulation of inflammatory responses. Specifically, the invention relates, in part, to compositions of and methods for using fibroblast growth factor (FGF) proteins, proteoglycans (e.g., syndecans), agents that modulate proteoglycans and agents that affect Wnt signaling. The invention also provides compositions and methods for treating subjects with undesired inflammatory activity and/or diseases associated therewith. The invention further provides, in part, compositions and methods for disrupting intercellular junctions with FGFs, such as for the enhanced delivery of therapeutic agents. | 2009-06-18 |
20090156478 | Acylated GLP-1 Compounds - Protracted GLP-1 compounds and therapeutic uses thereof. | 2009-06-18 |
20090156479 | Methods and Means for Controlling the Endocytosis and Subsequent Degradation of a Cell Surface Protein - The invention relates to the field of regulating metabolic processes, for example to regulate the presence and/or activity of a receptor at the surface of a cell. The invention provides a method for controlling the presence of a receptor at the surface of a cell comprising interfering with the interaction of an F-box protein with a ubiquitin/proteasome binding site of said receptor, wherein said ubiquitin/proteasome binding site comprises the amino acid sequence motif xDSWxEFIxxD or a sequence essentially corresponding thereto. The invention further provides a method for controlling the presence of a growth hormone receptor (GHR) at the surface of a cell comprising interfering with the interaction of an F-box protein with a ubiquitin/proteasome binding site of said GHR. | 2009-06-18 |
20090156480 | Biodegradable nanoparticle having t-cell recognizable epitope peptide immobilized thereon or encapsulated therein - A biodegradable nanoparticle having a T cell recognizable epitope peptide immobilized thereon or encapsulated therein of the present invention is usable as a safe and effective immunotherapeutic agent, and is useful as an immunotherapeutic agent for treating, for example, pollinosis, year-round nasal allergic disease and seasonal nasal allergic disease. | 2009-06-18 |
20090156481 | Use of Factor VIIa or Factor VIIa Equivalents for Preventing or Attenuating Haemorrhage Growth, and/or Oedema Generation Following Intracerebral Haemorrhage (ICH) in Patients Treated with Antiplatelet Therapy - The invention relates to the use of Factor VIIa or a Factor VIIa equivalent for the manufacture of a medicament for preventing complications in ICH patients treated with antiplatelet therapy. | 2009-06-18 |
20090156482 | EXTERNAL PREPARATION, METHOD OF PRODUCING THE SAME AND USAGE FOR THE SAME - The present invention provides an external preparation and the method for produce the same, in which said external preparation comprises recombinant human growth hormone or recombinant human granulocyte macrophage-stimulating factor and pharmaceutical acceptable carriers. The present invention also relates to application and usage method in preparing medicaments for treatment of various lesions and ulcer, especially corneal lesion and corneal ulcer. | 2009-06-18 |
20090156483 | Analogs of Ghrelin - The invention comprises peptidyl analogs according to formulae (I) or (II) as depicted below: | 2009-06-18 |
20090156484 | Use of Transferrins for Treating Destructive Inflammation of Mucous Membrane - Use of at least one transferrin, preferably lactoferrin, for preventing and/or treating destructive inflammation affecting mucous membranes, optionally associated with states of hypoferremia and/or anemia and/or acute and chronic infections. The destructive inflammation is caused, for example, by pathological conditions during pregnancy and by infections sustained by intracellular or adhered or biofilm-protected pathogens. The action of the transferrins described here is achieved by means of their topical and/or oral administration. A combined preparation for simultaneous, sequential or separate use is also described which comprises, as active components, a first composition for topical administration of at least one transferrin and a second composition for oral administration of at least one transferrin. | 2009-06-18 |
20090156485 | METHOD FOR COUPLING KERATIN-BINDING POLYPEPTIDES WITH EFFECTOR MOLECULES WHICH SUPPORT CARBOXYLIC GROUPS OR SULFONIC ACID GROUPS - The invention relates to a method of producing keratin-binding effector molecules and to intermediates and end-products of the method according to the invention and to the use of the keratin-binding effector molecules produced according to the invention in dermocosmetics. | 2009-06-18 |
20090156486 | PRODUCTION OF HUMAN DEFENSINS IN PLANT CELLS - The present invention relates, generally, to the production of human defensins from plant cells. Heterologous DNA comprising genes encoding one or more desired human defensins are introduced into plant cells. The one or more human defensins can be recombinantly-produced in the plant cells, purified from the plant cells, and used as an anti-infective agent, a wound treatment agent, a skin care agent, or an agent in the treatment of various intestinal diseases, including irritable bowel disease (IBD), ulcerative colitis, and Crohn's disease. The recombinantly-produced α-defensins can be provided as oral and topical formulations. | 2009-06-18 |
20090156487 | INFANT NUTRITIONAL COMPOSITIONS FOR PREVENTING OBESITY - The present invention relates to a method for preventing obesity later in life by administering a certain nutritional composition to an infant with the age between 0 and 36 months. The composition comprises linoleic and alpha-linolenic acid. | 2009-06-18 |
20090156488 | USE OF NEUREGULIN FOR ORGAN PRESERVATION - The present invention provides compositions and methods for preservation, perfusion or reperfusion of an organ, such as heart, for transplantation. The compositions comprise a preservation solution and an effective amount of neuregulin. The methods comprising contacting an organ with an effective amount of neuregulin. | 2009-06-18 |