24th week of 2011 patent applcation highlights part 49 |
Patent application number | Title | Published |
20110143317 | Straight Conic Mini Pillar Used in Outer Hexagon Implants - It is specifically a single body mini pillar, i e, a conic mini pillar body plus a fastening screw in a single piece, thus simplifying its installing process and superseding the model currently in use The new conic mini pillar prosthetic component has attained improvements on the screw region, obviating the furrow (channel), that previously generated product brittleness and also susceptible to fractures which are the clinical problems and difficult maintenance causes. With this evolution, the new conic mini pillar prosthetic component can endure higher installing torques around 32 N cm, in comparing with the prior model. | 2011-06-16 |
20110143318 | Winged implant - A winged implant may be provided with at least one wing extending generally radially away from a implant body adjacent a distal end thereof. During an implant procedure, the winged implant may be implanted in a crater, whereby the at least one wing may offer an enhanced support of the winged implant in the crater. | 2011-06-16 |
20110143319 | AERODYNAMIC SIMULATION SYSTEM AND METHOD FOR OBJECTS DISPENSED FROM AN AIRCRAFT - A system and method implemented on a computing device are provided to simulate trajectories of objects dispensed from a moving aircraft. | 2011-06-16 |
20110143320 | HEV BRAKE PEDAL SIMULATOR AIR GAP FILLER SYSTEM AND METHOD - A brake pedal simulator air gap filler system includes a brake pedal, a pedal feel simulator engaged by the brake pedal, a pedal push rod engaged by the brake pedal, a master cylinder/booster push rod spaced-apart from the pedal push rod, an air gap between the pedal push rod and the master cylinder/booster push rod, a master cylinder/booster engaged by the master cylinder/booster push rod and an air gap filling apparatus having an air gap filling head in adjacent proximity to the air gap and adapted to selectively engage and disengage the air gap. | 2011-06-16 |
20110143321 | Portable multifunctional communication and environment aid for the visually handicapped - A processor, portable power source and Braille character touchpad with a first column area is described, containing three substantially linearly arranged finger responsive areas corresponding to column representations of a Braille character and an adjacent-offset second column area containing one finger responsive area to indicate a null column. Braille character is input by engaging at least one area of the three substantially linearly arranged finger responsive areas and the one finger responsive area. Alternatively, a Braille touchpad containing six finger responsive areas arranged in two columns corresponding to first and second column representations of a Braille character and an adjacent touch gesture pad is described, containing a plurality of finger and gesture responsive areas. A Braille character is input by engaging at least one of the six finger responsive areas and the plurality of finger and gesture responsive areas. Word processing and command action may be initiated by the gesture pad. | 2011-06-16 |
20110143322 | METHOD FOR WEIGHT MANAGEMENT - A method for managing the weight of a user is disclosed. The method comprises a) obtaining the energy expended by the user preferably in a day b) modeling the user's weight management and predicting the target weight that can be reached and the target time period required for achieving the predicted target weight based on the obtained energy expended in combination with the current weight of the user c) using the model and devising a weight management plan that the user has to pursue for a pre-determined time period d) using the devised weight management plan and coaching the user on a daily basis for the pre-determined time period and e) monitoring the progress at the end of the pre-determined time period and checking whether the user's weight is differing with respect to the weight that is to be achieved based on where the user is currently in the target time period and if so repeating step a, step b, step c and step d. | 2011-06-16 |
20110143323 | LANGUAGE TRAINING METHOD AND SYSTEM - A language training system allows students to receive on-demand training in language skills with remotely situated instructors. The training is provided in diverse languages and topics. A system includes a database of conversations a student may select from. After a conversation is selected, the student also selects an instructor to provide the training. The system established real-time communication between the student and selected instructor and supply a script for the selected conversation. | 2011-06-16 |
20110143324 | ADJUSTABLE PITCH SIMULATED ROOF FOR TRAINING FIREFIGHTERS IN ROOF VENTILATION PROCEDURES - An adjustable pitch simulated roof for training firefighters in roof ventilation procedures. The apparatus includes a vertical support structure and a pitched roof portion adjustably connected to the vertical support structure. The pitched roof portion includes an outer frame defining an interior region, a plurality of rafter brackets disposed on the outer frame, a plurality of rafters placed the interior region, and a plurality of roofing sheets covering the rafters so as to form a roof field. A mechanical winch or other adjustment means are provided for rapidly and easily changing the roof pitch, and a locking mechanism locks the roof portion in the selected position. A stationary and a trailer-mounted mobile embodiment are each shown and described. | 2011-06-16 |
20110143325 | Automatic Integrity Checking of Quran Script - An independent automated mechanism is invented that is able to:
| 2011-06-16 |
20110143326 | System for circadian rhythm monitor with synchrony and activity planning - A personal health system which includes a suitable Core Body Temperature (CBT) monitor that can be worn for all or part of a 24 hour day and collect continuous CBT data. The CBT data is collected and compared to determine circadian desynchrony. A conveniently carried or worn processor/display unit, in communication with the CBT monitor, algorithmically determines activity types and activity timing based on the collected CBT data to improve synchrony. The activities and when to perform them are displayed to the user. | 2011-06-16 |
20110143327 | METHOD FOR FACILITATING ASSESSMENT OF A COURSEWORK ANSWER AND MODERATING THE ASSESSMENT - A method for facilitating assessment of an answer to a coursework question and moderating the assessment, the method comprising the steps of displaying at least part of a representation of a coursework answer on a display of a computer, displaying a list of learning outcome statements, selecting a learning outcome statement from the list of learning outcome statements and placing the learning outcome statement on the representation of the coursework answer at a location evidencing fulfillment of the learning outcome statement. | 2011-06-16 |
20110143328 | Method and Apparatus for Enhancing an Academic Environment - A method for guiding a problem solver includes determining one or more fundamental skills necessary to solve a problem. The method also includes associating the one or more fundamental skills with the problem in an electronic format. The method further includes selecting one or more portions of media corresponding to the one or more fundamental skills and presenting a user with an electronic display of at least one of the one or more portions of media corresponding to the one or more fundamental skills associated with the problem. | 2011-06-16 |
20110143329 | Methods and Apparatus Enabling Meeting Notes to be Inscribed on Electrostatis Film and Retained - A meeting attendee brings into a meeting room a kit which includes a container possessing a supply cylinder on which conventional electrostatic or electret film/paper is wound, a retention cylinder, and, optionally, writing implements. A sheet of the electrostatic film is unwound from the supply roll and is applied to a vertical surface to which it clings by electrostatic attraction. The exposed side of the sheet is written-on by conventional writing tools. Following the meeting, one or more of the sheets is peeled from the surface and retained by being wound up and placed into the retention cylinder. The retention cylinder can then be removed from the meeting room within the container or separately therefrom. | 2011-06-16 |
20110143330 | COMBINATION DRY ERASE BOARD/PROJECTION SCREEN - A communication article comprising a face layer on the front side of said article, said face layer having structured front surface and a base layer, wherein the face layer has a fluorine content of 0.02 mass % to 0.1 mass % in a solid basis. Preferred embodiments further comprise a buffer layer disposed between the face layer and base layer. | 2011-06-16 |
20110143331 | Methods and Compositions for the Preservation of Cells and Tissues - Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample. | 2011-06-16 |
20110143332 | METHOD FOR IDENTIFYING MICROORGANISM OR DETECTING ITS MORPHOLOGY ALTERATION USING SURFACE ENHANCED RAMAN SCATTERING (SERS) - The present invention relates to a method for producing a profile identifying a microorganism based on surface enhanced Raman scattering (SERS) and an apparatus thereof. The method comprises: (1) placing the microorganism on a SERS-active substrate; (2) mounting the microorganism with a mounting solution; (3) obtaining a SERS spectrum of the microorganism in step (2); and (4) analyzing the SERS spectrum to produce the profile. | 2011-06-16 |
20110143333 | ANTI-CHIKUNGUNYA MONOCLONAL ANTIBODIES AND USES THEREOF - The present invention relates to the field of arbovirosis caused by Chikungunya virus (CHIK). The present invention specifically concerns anti-CHIK monoclonal antibodies (MAbs), and more specifically anti-CHIK.E2 MAbs and their use as diagnostic products in methods for detecting the presence or absence of a CHIK strain. | 2011-06-16 |
20110143334 | MICROBIOLOGICAL SYSTEMS AND METHODS OF FLUID SAMPLE ANALYSIS - Methods and systems for detecting the presence of a target microorganism in a liquid sample are provided. Methods comprise the steps of passing the liquid sample through a surface filter, placing the surface filter into contact with a culture device, incubating the culture device for a period of time and detecting the presence of a target microorganism. Methods may be used with an automated detection system. | 2011-06-16 |
20110143335 | METHODS AND SYTEMS TO CAPTURE COMPETITIVE MOLECULES - Methods and systems to capture competitive molecules, such as to reduce false positives in an assay. Competitive molecules may be captured in a fluid moving through a portable point-of-care diagnostic assay system. | 2011-06-16 |
20110143336 | MARKER FOR ESTIMATING THE DIAGNOSIS OF CERVICAL ADENOCARCINOMA OR FOR ESTIMATING THE PROGNOSIS OF CERVICAL CANCER - To provide a novel biomarker for estimating the diagnosis of cervical adenocarcinoma or for estimating the prognosis of cervical cancer. An antibody against Villin 1 is employed as a biomarker. | 2011-06-16 |
20110143337 | UNSYMMETRICAL CYANINE DIMER COMPOUNDS AND THEIR APPLICATION - Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA. | 2011-06-16 |
20110143338 | NUCLEIC ACID ENZYMES AND COMPLEXES AND METHODS FOR THEIR USE - The present invention relates to methods that utilise multi-component nucleic acid complex (MNA complex) cascades. The MNA complexes may have cleavage or ligase activity. Further, the invention provides cascades which may include one or more DNAzymes. The invention also provides methods which use these cascades for the identification, detection and quantification of targets. | 2011-06-16 |
20110143339 | Device, System and Method for Processing a Sample - A device for processing a sample comprises a blister defined by first and second walls. The first wall is flexible allowing the blister to be divided into one or more sealed regions by an external pressure applied to a portion of the first wall. The external pressure is applied in the form of a 2-dimensional shape to form a sealed region having that shape. | 2011-06-16 |
20110143340 | NON-INVASIVE ISOLATION OF FETAL NUCLEIC ACID - The present invention provides compositions comprising a solution of a compound useful for lysing biological cells and methods for using the compositions to lyse biological cells and to isolate nucleic acid. | 2011-06-16 |
20110143341 | Microsatellite Markers of Schizophrenia - The invention includes methods of determining if a subject is at risk for developing schizophrenia (SZ). | 2011-06-16 |
20110143342 | NEW FETAL METHYLATION MARKERS - This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions. | 2011-06-16 |
20110143343 | Methods and Kits for Methylation Detection - Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation reaction. In certain embodiments, at least one ligation product, at least one ligation product surrogate, at least one misligation product, at least one misligation product surrogate, or combinations thereof are amplified. In certain embodiments, one or more ligation probes comprise at least one nucleotide analog, at least one Modification, at least one mismatched nucleotide, or combinations thereof. | 2011-06-16 |
20110143344 | GENETIC POLYMORPHISMS AND SUBSTANCE DEPENDENCE - The invention encompasses methods for identifying subjects at risk for substance dependence by detecting the presence of polymorphism in the CHRNA5-CHRNA3-CHRNB4 gene cluster and the CHRNA4 gene. The invention also encompasses determining the response of a subject to a therapeutic substance, treating substance dependence in a subject, and evaluating the response of a subject to a substance cessation treatment. | 2011-06-16 |
20110143345 | Genetic Markers for SCD or SCA Therapy Selection - Variations in certain genomic sequences useful as genetic markers of Sudden Cardiac Death (“SCD”) or Sudden Cardiac Arrest (“SCA”) risk are described. Novel genetic markers useful in assessing the risk of SCD or SCA and compositions containing the same are provided herein. Methods of distinguishing patients having an increased susceptibility to SCD or SCA, through use of these markers, alone or in combination with other markers, are also provided. Further, methods of detecting a polymorphism associated with SCD or SCA are taught. | 2011-06-16 |
20110143346 | COTTON EVENT MON15985 AND COMPOSITIONS AND METHODS FOR DETECTION THEREOF - The present invention provides cotton plants, cotton tissues, and cotton seeds that include the MON15985 event, which confers resistance to Lepidopteran insect damage. Also provided are assays for detecting the presence of the MON15985 event based on the DNA sequence of the recombinant construct inserted into the cotton genome that resulted in the MON15985 event and/or the genomic sequences flanking the insertion site. | 2011-06-16 |
20110143347 | SUBSTANCES AND METHODS FOR A DNA BASED PROFILING ASSAY - The present invention relates to a DNA profiling assay comprising the following steps, providing a sample to be analyzed, providing reagents, enzyme and primer oligonucleotides which are necessary for simultaneous polymerase chain reaction amplification of at least 20 loci, amplifying the loci, detecting the amplification products, wherein the amplification products and the loci to be amplified are characterized by the following features, each locus to be amplified is characterized by at least one deletion-insertion polymorphism known to be present in the population, wherein the two alleles from each locus differ in size by more than 2 nucleotides and less than 100 nucleotides, a first set of at least two amplification products ranging in size from about 20 nucleotides to about 300 nucleotides stemming from at least two different loci carries a first label, a second set of at least two amplification products ranging in size from about 20 nucleotides to about 300 nucleotides stemming from at least two different loci carries a second label, a third set of at least two amplification products ranging in size from about 20 nucleotides to about 300 nucleotides stemming from at least two different loci carries a third label, label one, label two and label three are each different fluorescent labels which can he differentiated and simultaneously detected by a multi-colour detector in combination with, e.g. a DNA sequencing device. | 2011-06-16 |
20110143348 | METHOD FOR QUANTIFYING OR DETECTING DNA - The present invention relates to a method for quantifying or detecting DNA having a target DNA region, and so on. | 2011-06-16 |
20110143349 | METHODS AND COMPOSITIONS FOR DETECTING BK VIRUS - The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention. | 2011-06-16 |
20110143350 | PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS - The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR. | 2011-06-16 |
20110143351 | GLYOSYLATION MARKERS FOR CANCER AND CHRONIC INFLAMMATION - The present invention provides novel biomarkers for use in the diagnosis and prognosis of cancerous and malignant conditions and further of diseases which are mediated by a proinflammatory immune response. The biomarkers are glycoproteins, the levels of expression of which have been correlated by the inventors to correspond to particular disease conditions. The invention further extends to methods for use in monitoring the response to therapy of a treatment for use in the treatment of a cancerous condition or proinflammatory disease. | 2011-06-16 |
20110143352 | Methods for the Reduction of Stutter in Microsatellite Amplification - The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a G+C content of 50% or less; contacting the sample with at least one enzyme having nucleic acid polymerase activity; and incubating the sample with the enzyme for a sufficient amount of time and under conditions sufficient to amplify the microsatellite; wherein the incubation is performed in the presence of an amount of betaine, sorbitol or mixtures thereof, effective to reduce stutter relative to the amount of stutter observed in the absence of betaine and/or sorbitol. The invention also provides compositions containing betaine and/or sorbitol, kits for amplifying microsatellites having a G+C content of 50% or less, and methods of using all of the foregoing. | 2011-06-16 |
20110143353 | METHOD FOR IN VITRO DETECTION AND/OR QUANTIFICATION AND/OR IDENTIFICATION OF INFECTIOUS COMPOUNDS IN A BIOLOGICAL MATERIAL - Method for in vitro detection and/or quantification and/or identification of bacteria present in a fluid medium M constituting a biological material, in which method a suspension of microbeads of solid polymer material capable of binding proteins is prepared; the microbeads are loaded with β2GPI proteins; said loaded microbeads are brought into contact with the fluid medium M, in the presence of ions of an oxidizing metal, so as to bind the bacteria to the β2GPI proteins; the microbeads thus prepared are separated from their suspension medium, so as to obtain a residue; and the bacteria of the residue are detected and/or quantified and/or identified. | 2011-06-16 |
20110143354 | Universal primers and their use for detecting and identifying plant materials in complex mixtures - Polynucleotides and primers flanking a variable region of the intron of the chloroplast gene trnL of plant materials for detecting and identifying plant species, and methods for detecting and identifying plant species in complex or degraded mixtures. | 2011-06-16 |
20110143355 | Systems for genome selection - Systems, methods, compositions and apparatus relating to genome selection are disclosed. | 2011-06-16 |
20110143356 | THERMOSTABLE POLYMERASES HAVING ALTERED FIDELITY AND METHODS OF IDENTIFYING AND USING SAME - The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic selection. For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase. The invention also provides thermostable polymerases and nucleic acids encoding thermostable polymerases having altered fidelity, for example, high fidelity polymerases and low fidelity polymerases. The invention additionally provides a method for identifying one or more mutations in a gene by amplifying the gene with a high fidelity polymerase. The invention further provides a method for accurately copying repetitive nucleotide sequences using a high fidelity polymerase mutant. The invention also provides a method for diagnosing a genetic disease using a high fidelity polymerase mutant. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant. | 2011-06-16 |
20110143357 | SYSTEM AND METHOD FOR HIGH RESOLUTION ANALYSIS OF NUCLEIC ACIDS TO DETECT SEQUENCE VARIATIONS - Provided herein are methods for assaying a biological sample for microorganisms having drug resistant and/or drug sensitive phenotypes, wherein the methods are capable of detecting resistant and sensitive phenotypes associated with known and/or unknown mutations. In some aspects, methods are provided for detecting drug resistant | 2011-06-16 |
20110143358 | COMPOSITIONS FOR USE IN IDENTIFICATION OF TICK-BORNE PATHOGENS - The present invention relates generally to the field of genetic identification and quantification of tick borne pathogens and provides methods, compositions and kits useful for this purpose when combined with molecular mass or base composition analysis. | 2011-06-16 |
20110143359 | Method for Identifying Drug-Sensitizing Antisense DNA Fragments and Use Thereof - The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a template; fragmentation of the DNA by sonication or other means; selecting DNA fragments no longer than 400 base pairs; ligating the DNA fragments into a suitable expression plasmid with a selectable marker; transforming the plasmids containing the DNA fragments into the organism from which the gene of interest originated; and selecting clones from transformed cells that show a phenotypic difference of the clone grown in the presence of the inducer relative to the phenotype in the absence of inducer. | 2011-06-16 |
20110143360 | CANCER MARKER, METHOD FOR EVALUATION OF CANCER BY USING THE CANCER MARKER, AND EVALUATION REAGENT - The present invention provides a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject, and an evaluation method using the same. A cancer marker containing at least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as a marker for cancers excluding breast cancer. A method for evaluating the possibility of cancers excluding breast cancer includes the step of detecting the expression level of a cancer marker in a biological sample collected from a subject. In this method, the cancer marker contains at least one miRNA selected from hsa-miR-92 and hsa-miR-494. | 2011-06-16 |
20110143361 | PREDICTIVE VALUE OF NUCLEAR EXCISION REPAIR GENES FOR CANCER SURVIVAL - Patients who have their cancer surgically removed are at risk for recurrence, even though currently free of disease. Lung cancer patients with higher activity of a nuclear excision repair gene called ERCC1 were at a lower risk for recurrence than patients with lower activity of ERCC1. Hence, it is possible to predict which patients are at a higher risk for recurrence after resection. This information can be used to design treatment strategies for patients determined to be at a higher risk for recurrence. Additionally, patients who are lower risk for recurrence can be saved the morbidity of further treatment. | 2011-06-16 |
20110143362 | METHOD FOR IDENTIFICATION OF PROTEASE ACTIVITY INHIBITORS AND ASSAYING THE PRESENCE OF PROTEASE ACTIVITY - A system for the identification of proteases and protease inhibitors is provided. The system has at least two components. The first component is a reporter construct with at least one binding site, a transcriptional promoter, an inducible promoter region, and at least one reporter gene, all functionally connected for expression of the reporter gene(s) in functional coordination with a transcriptional activation agent. The second component is a transcriptional activation agent comprising a nucleic acid binding domain, at least one protease substrate domain, and at least one transcriptional activation domain for an inducible promoter. The system allows detection and evaluation of agents affecting protease activity directed to the protease substrate domain. The system also allows for the detection of the presence of proteases in environmental samples. | 2011-06-16 |
20110143363 | DETERMINATION OF FREE FRACTIONS - The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmacologically active compounds in aqueous solutions and serum. The invention also relates to the above methods in which solid particles, coated with a lipophilic medium, are used. | 2011-06-16 |
20110143364 | CENTRIFUGAL MICRO-FLUIDIC STRUCTURE FOR MEASURING GLYCATED HEMOGLOBIN, CENTRIFUGAL MICRO-FLUIDIC DEVICE FOR MEASURING GLYCATED HEMOGLOBIN, AND METHOD FOR MEASURING GLYCATED HEMOGLOBIN - Disclosed are a centrifugal micro-fluidic structure for measuring glycated hemoglobin, a centrifugal micro-fluidic device for measuring glycated hemoglobin, and a method for measuring glycated hemoglobin. According to the disclosure, immunosorbent assay and affinity measurements are simultaneously conducted using only a single device in order to detect hemoglobin variants or interfering substances and, therefore, the detected results are applied to analysis of measurement results so as to eliminate and/or compensate for, or calibrate errors in measurement of, glycated hemoglobin, thereby more accurately measuring the glycated hemoglobin. | 2011-06-16 |
20110143365 | METHODS AND DEVICES TO ENHANCE SENSITIVITY AND EVALUATE SAMPLE ADEQUACY AND REAGENT REACTIVITY IN RAPID LATERAL FLOW IMMUNOASSAYS - Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods and devices provide for delivery of a diluted liquid sample to a single location that simultaneously directs the liquid flow along two or more separate flow paths, one that serves as a positive control to confirm that all critical reagents of the test are immunoreactive, and that the sample being tested is adequate, and the other to detect specific antibodies if present. | 2011-06-16 |
20110143366 | PROTEIN BIOMARKERS FOR IN VITRO TESTING OF DEVELOPMENTAL TOXICITY AND ENBRYOTOXICITY OF CHEMICAL SUBSTANCES - Presently, the toxicological assessment of chemicals is mainly performed in vivo using a variety of animal species and in addition taking into account human clinical, biochemical, pathological and morphological data. Over the past years it became increasingly clear that some substances are particularly harmful for children and thus there is a focus on the special vulnerability of the developing human brain. Meanwhile there is a recommendation to test substances with a known neurotoxic or teratogenic (in particular a neuroteratogenic) risk additionally for embryotoxicity. Moreover the US Environmental Protection Agency (EPA) requires embryotoxicity tests for pesticides. Further tests are required if substances shall be used as medicaments (S7A Safety Pharmacology Studies for Human Pharmaceuticals, Guidelines of the International Conference on Harmonization, ICH, 2001). | 2011-06-16 |
20110143367 | ANTIBODIES AGAINST APRIL AS BIOMARKERS FOR EARLY PROGNOSIS OF LYMPHOMA PATIENTS - The invention relates to antibodies directed against APRIL (A Proliferation Inducing TNF Ligand, also known as TALL-2), in particular the monoclonal antibody Aprily-2, hybridoma cells producing monoclonal antibody Aprily-2, and the use of a combination of an antibody against membrane-anchored APRIL and Aprily-2 in the diagnosis of B cell lymphoma resistance to treatment and the prognosis of clinical development of Diffuse Large B-Cell (DLBCL) lymphoma from high risk patients (>60 years and International Prognostic Index >2). An amino acid sequence GTGGPSQNGEGYP called Stalk, useful in the preparation of antibodies, is described. | 2011-06-16 |
20110143368 | Tyrosine phosphorylation sites - The invention discloses 142 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2011-06-16 |
20110143369 | METHOD FOR DETERMINING TREATMENT OF DISSEMINATED INTRAVASCULAR COAGULATION - A method for determining an appropriate treatment option for a patient who has been diagnosed with disseminated intravascular coagulation (DIC) but who may have thrombotic thrombocytopenic purpura (TTP), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) and the amount of vWF in a patient that has been diagnosed with DIC is disclosed. Using the method of the present invention, a differential diagnosis of patients with thrombotic thrombocytopenic purpura (TTP) can be made from among patients diagnosed with DIC, which could not previously be distinguished on the basis of only clinical findings or known markers. Also disclosed is a kit for determining an appropriate treatment option, the kit comprising an antibody or a fragment thereof which specifically binds to ADAMTS13. | 2011-06-16 |
20110143370 | Nucleic Acids Encoding a Mammalian Raptor Polypeptide and Uses Therefor - The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein. | 2011-06-16 |
20110143371 | PROCOLLAGEN C-PROTEINASE ENHANCER (PCPE) BIOMARKER FOR BONE FORMATION - Use of PCPE, preferably PCPE-1, as a diagnostic marker. | 2011-06-16 |
20110143372 | ANTIBODIES AGAINST HUMAN EPO RECEPTOR - An antibody binding to human EPO receptor, characterized in specifically binding EPO receptor fragment LDKWLLPRNPPSEDLPGPGGSVDIV (SEQ ID NO:1), CSSALASKPSPEGASAASFEY (SEQ ID NO:2), or GGLSDGPYSNPYENSLIPAAEP (SEQ ID NO:3) is useful for the analysis of EPO receptor in human tissue. | 2011-06-16 |
20110143373 | METHOD OF EVALUATING THE INTEGRITY OF THE PLASMA MEMBRANE OF CELLS BY DETECTING GLYCANS FOUND ONLY INTRACELLULARLY - The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell preparation to potentially harmful conditions. It can also be used as a quality control tool in methods in which intact cell membrane is essential and it can be applied in separation of damaged cells from non- damaged. | 2011-06-16 |
20110143374 | Methods to Identify Modulators of the Interaction Between Dextromethorphan and the Bitter Taste Receptor TAS2R46 - TAS2R46 was identified as a dextromethorphan-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of dextromethorphan are provided. | 2011-06-16 |
20110143375 | BIOMARKER DETECTION PROCESS AND ASSAY OF NEUROLOGICAL CONDITION - The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage. | 2011-06-16 |
20110143376 | Methods to Identify Modulators - TAS2R7 was identified as a menthol-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of menthol are provided. | 2011-06-16 |
20110143377 | Protein fragments of virB10 and sero-detection of anaplasma phagocytophium - Disclosed are cloning and expression of a plurality of protein fragments of virB10, a Type IV Secretion System (TIVSS) in | 2011-06-16 |
20110143378 | MICROFLUIDIC METHOD AND APPARATUS FOR HIGH PERFORMANCE BIOLOGICAL ASSAYS - The present invention provides a disposable microfluidic assay cartridge ( | 2011-06-16 |
20110143379 | DETECTION AND QUANTITATION OF FULL-LENGTH THIOREDOXIN (TRX) AND TRUNCATED THIOREDOXIN (TRX 80) IN COMPLEX SAMPLES - The present invention relates, e.g., to a method for detecting a full-length protein and a truncated form (e.g., a naturally occurring cleavage product) thereof, in a sample, comprising
| 2011-06-16 |
20110143380 | ALZHEIMER'S DISEASE BIOMARKERS AND METHODS OF USE - The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD. | 2011-06-16 |
20110143381 | DIAGNOSIS AND MONITORING OF CHRONIC RENAL DISEASE USING NGAL - A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as over time. Incremental increases in NGAL levels in CRF patients over a prolonged period of time are diagnostic of worsening kidney disease. This increase in NGAL precedes and correlates with other indicators of worsening chronic renal disease or CRF, such as increased serum creatinine, increased urine protein secretion, and lower glomerular filtration rate (GFR). Proper detection of worsening (or improving, if treatment has been instituted) renal status over time, confirmed by pre- and post-treatment NGAL levels in the patient, can aid the clinical practitioner in designing and/or maintaining a proper treatment regimen to slow or stop the progression of CRF. | 2011-06-16 |
20110143382 | IgA Nephropathy Testing Method And Test Kit - There is provided a renal disease testing method comprising a complex detection step of detecting a complex of an antigen derived from human renal mesangial cells and human IgA in a sample derived from urine collected from a subject. It is preferred that the renal disease testing method of the invention further comprises a determination step of assessing the whether the renal disease is IgA nephropathy based on the ratio of the amount of the complex detected in the complex detection step to the amount of urinary proteins in the sample. The renal disease testing method of the invention has good detection sensitivity and specificity, and can conveniently and safely assess the existence of a renal disease (preferably, IgA nephropathy). | 2011-06-16 |
20110143383 | MICROFLUIDIC DEVICE - A microfluidic device comprising a flow channel with an inlet and a gas escape opening is described. The flow channel comprises a liquid flow channel section and a flow controlling section downstream to the liquid flow channel section and upstream to or coinciding with the gas escape opening. The flow controlling section provides a flow resistance to gas, which is sufficiently high to reduce velocity of a capillary flow of a liquid in the liquid flow channel section. | 2011-06-16 |
20110143384 | METHODS OF PEPTIDE MODIFICATION - The present invention relates to a method of improving the resistance of a peptide or peptidomimetic to degradation by trypsin which comprises incorporating into said peptide or peptidomimetic a C-terminal capping group of formula (I): X—Y—Z (I) wherein X is a N atom, which may be substituted by a branched or unbranched C | 2011-06-16 |
20110143385 | PLASMA MEMBRANE VESICLES AND METHODS OF MAKING AND USING SAME - The instant invention provides plasma membrane vesicles, methods of making the same, and method of using the plasma membrane vesicles. | 2011-06-16 |
20110143386 | METHOD FOR THE ANALYSIS OF O-LINKED OLIOSACHARIDES - A method of analyzing O-linked oligosaccharides in a sample is disclosed. The method comprises the steps of digesting a glycoprotein with a proteolytic enzyme, performing solid-phase permethylation of the oligosaccharide, then analyzing the permethylated and non-reduced O-linked oligosaccharides using MALDI-TOF mass spectrometry. | 2011-06-16 |
20110143387 | HIGHLY WATER-SOLUBLE, CATIONIC LUMINESCENT LABELS - Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: | 2011-06-16 |
20110143388 | METHOD OF PROVIDING PORTABLE BIOLOGICAL TESTING CAPABILITIES - A method for providing portable biological testing capabilities free from biological contamination from an environment outside the device is provided. The method includes providing components configured to be assembled together to seal a volume against passage of biological materials between the volume and an environment outside the volume. The method further includes sterilizing the components and providing a sterilized culture medium. The method further includes assembling the components together with the sterilized culture medium within the volume. The method further includes sterilizing the assembled components by elevating the temperature. The method further includes flowing gas from within the volume to the environment while at an elevated temperature. The method further includes reducing the temperature to be less than the elevated temperature while preventing gas from flowing from the environment to the volume, thereby creating a pressure within the volume which is less than a pressure outside the volume. | 2011-06-16 |
20110143389 | CELL ANALYSIS APPARATUS AND METHODS - Particular embodiments of the inventive technology relate to ‘off-axis detector’ technology that employs a third detector | 2011-06-16 |
20110143390 | METHOD FOR TESTING DRUG SENSITIVITY AND DEVICE USED THEREFOR - A method for testing drug sensitivity including: a) concentrating a bacterium or cell sample to be tested; b) adding a culture solution to the bacterium or cell sample to yield a liquid sample, the culture solution comprising a nutrient and a colloidal material; c) adding a coagulant aid to the liquid sample where the coagulant aid reacts with the colloidal material to yield a gel test sample; d) pasting drug paper on the surface of the gel test sample; e) culturing the gel test sample in an incubator; and f) observing the formation of a drug inhibition zone and determining the drug sensitivity of the bacterium or cell. A device used for testing drug sensitivity according to the method is also provided. The method and the device have short testing time, low cost, and safe operation. | 2011-06-16 |
20110143391 | METHOD FOR TYPING AND IDENTIFICATION OF MICRO-ORGANISMS - The invention relates to a method for typing or identification of a micro-organism using vibrational spectroscopy, characterised in that, differences in one or more vibrational spectroscopic signal contributions from one or more bleachable components between different spectra obtained of a sample of said micro-organism, and/or between spectra of different samples of said micro-organism, and/or between spectra of samples of different micro-organisms, are substantially eliminated as a source of signal variance in a dataset of said spectra, said bleachable components being molecules possessing vibrational spectral bands that upon exposure to light show a reduction in signal intensity. | 2011-06-16 |
20110143392 | Biological fixative and method of using the biological fixative - A composition that includes an aldehyde, alcohol, and a ketone, the volumetric ratio of the alcohol to the ketone in the composition ranging from as low as about 0.8:1 to as high as about 4.5:1 and the volumetric ratio of the alcohol to the aldehyde in the composition ranging from as low as about 41.5:1 to as high as about 450:1. | 2011-06-16 |
20110143393 | AUTOMATIC DEVICE FOR CARRYING OUT DETECTION REACTIONS, AND METHOD FOR DOSING REAGENTS ONTO MICROSCOPE SLIDES - The invention relates to an automatic device to meter reagents onto a multitude of slides comprising holding devices for a multitude of slides which contain each a multitude of separated slots which are adapted to absorb cell or tissue samples; a dosing head unit with a multitude of reservoirs which are adapted to absorb liquid reagents and which have a metering valve at the end/side facing the slots to dose and apply the reagents into the slots; a positioning device to position the reservoirs of the dosing head unit above the respective slots of the slides. | 2011-06-16 |
20110143394 | Methods and Means for Metabolic Engineering and Improved Product Formation by Micro-Organisms - The invention relates to the field of biochemistry, molecular biology and microbiology. More specific the invention relates to methods and means for metabolic engineering and improved product formation by a filamentous micro-organism or a low G+C gram-positive bacterium. | 2011-06-16 |
20110143395 | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods - Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from | 2011-06-16 |
20110143396 | VECTORS AND YEAST STRAINS FOR PROTEIN PRODUCTION: CA2+ ATPASE OVEREXPRESSION - Lower eukaryote host cells in which an endogenous or heterologous Ca | 2011-06-16 |
20110143397 | RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS - The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs. | 2011-06-16 |
20110143398 | Methods of saccharification of polysaccharides in plants - Saccharification of polysaccharides of plants is provided, where release of fermentable sugars from cellulose is obtained by adding plant tissue composition. Production of glucose is obtained without the need to add additional β-glucosidase. Adding plant tissue composition to a process using a cellulose degrading composition to degrade cellulose results in an increase in the production of fermentable sugars compared to a process in which plant tissue composition is not added. Using plant tissue composition in a process using a cellulose degrading enzyme composition to degrade cellulose results in decrease in the amount of cellulose degrading enzyme composition or exogenously applied cellulase required to produce fermentable sugars. | 2011-06-16 |
20110143399 | DNA JOINING METHOD - The present invention provides a method to directionally clone any linear template DNA molecule into any linearized vector. The vector ends may be generated from any restriction enzyme cleavage. The method does not require a ligation step nor the use of carefully controlled conditions as is required with methods involving specific exonucleases alone. It has been determined that specific DNA polymerases are able to efficiently join one or more linear DNA molecules sharing ends with appropriate complementation. | 2011-06-16 |
20110143400 | SIRNA AND METHODS OF MANUFACTURE - Double-stranded RNA of about 19 to about 25 nucleotides in length capable of regulating gene expression by RNA interference is provided. Such double-stranded RNA are particularly useful for treating disease or conditions associated with a target mRNA or gene. Methods of manufacture and methods of use of the double-stranded RNA are also provided. | 2011-06-16 |
20110143401 | Devices to Extend Single Stranded Target Molecules - A polynucleotide device is provided that add one or more bases to a single stranded polynucleotide. Methods of using the device and kits comprising the device are also provide. | 2011-06-16 |
20110143402 | DEGRADATION OF LIGNOCELLULOSIC MATERIAL - The present invention describes a method for the treatment of lignocellulosic material which method comprises contacting said lignocellulosic material with a composition comprising two or more enzyme activities, said enzyme activities being cellulase and/or hemicellulase activities, wherein the pH during the treatment is about 4.5 or lower, and the treatment is carried out at a dry matter content of 15% or more. | 2011-06-16 |
20110143403 | METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY - There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease. | 2011-06-16 |
20110143404 | PROCESS FOR PRODUCING A PHOSPHOLIPID - A process for preparing phosphatidylserine comprises reacting a phospholipid with serine in the presence of water, a phospholipase D from carrot and at least one surfactant. A process for preparing phosphatide acid comprises hydrolysing a phospholipid in the presence of water and a phospholipase D from carrot. | 2011-06-16 |
20110143405 | DICARBOXYLIC ACID PRODUCTION IN A RECOMBINANT YEAST - The present invention relates to a recombinant yeast comprising a nucleotide sequence encoding a heterologous enzyme that catalyses the conversion of malic acid to fumaric acid. The invention further relates to a process for the production of a dicarboxylic acid wherein the yeast according to the present invention is used. | 2011-06-16 |
20110143406 | Novel (S,S) -Butanediol Dehydrogenase, Gene for the Same, and Use of the Same - The present invention has its object to provide a novel (S,S)-butanediol dehydrogenase. The present invention also has its object to provide a gene coding for the enzyme protein, a vector containing the gene, a transformant harboring the vector, and a method of producing an optically active alcohol using the transformant. The polypeptide according to one embodiment of the present invention has the physicochemical properties including actions such as: acting on (2S,3S)-2,3-butanediol to form (S)-acetoin in the presence of NAD | 2011-06-16 |
20110143407 | Continuous Single Vessel Butanol Synthesis by Fermentation - The present invention describes a method for producing butanol by fermentation of carbohydrates using mixed populations of acidogenic-phase cells and solventogenic-phase cells of | 2011-06-16 |
20110143408 | ZYMOMONAS WITH IMPROVED ARABINOSE UTILIZATION - Several strains of arabinose-utilizing | 2011-06-16 |
20110143409 | METHOD FOR PRODUCING ETHANOL FROM XYLOSE USING RECOMBINANT SACCHAROMYCES CEREVISIAE INVOLVING COUPLED USE OF NADH AND NAD+ - Disclosed is a method for producing ethanol from xylose using recombinant | 2011-06-16 |
20110143410 | Processes for Producing Fermentation Products - The present invention relates to methods of increasing fermentation product yield in processes for producing fermentation products from starch-containing material. More particularly, the process comprises the use of an invertase to increase fermentation product yield. | 2011-06-16 |
20110143411 | Biomass fractionation process for bioproducts - A fractionation process for producing value-added products from a lignocellulosic biomass, comprises: a) mechanically refining the lignocellulosic biomass under mild refining conditions to form a refined biomass pulp with enhanced susceptibility to separation of hemicellulose, cellulose and lignin, and enhanced digestibility of carbohydrates in hydrolysis b) separating hemicellulose and sulfur-free high-quality lignin from cellulose in the refined biomass, and, optionally c) producing various bioproducts from the above said process. | 2011-06-16 |
20110143412 | METHOD AND APPARATUS FOR PRETREATING BIOMASS USING INTERNAL HEAT - A method for pretreating a biomass, in which a water-reactive anhydride contacts a biomass, is disclosed. The biomass is pretreated using internal heating by an exothermic reaction. Further, an apparatus for pretreating a biomass having a reaction part including an inlet part and an outlet part for the water-reactive anhydride is disclosed. | 2011-06-16 |
20110143413 | System And Method For Controlling Bacterial Cells With Weak Electric Currents - A system and method for treating bacterial cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate bacterial cells. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has broad spectrum applications in treating chronic and drug resistant infections, such as those caused by | 2011-06-16 |
20110143414 | MICROFLUIDIC DEVICE AND METHOD FOR CONCENTRATION AND LYSIS OF CELLS OR VIRUSES - A microfluidic device for the concentration and lysis of cells or viruses and a method of concentrating and lysing cells or viruses using the microfluidic device include: magnetic beads, a reaction chamber in which the magnetic beads are accommodated and a laser source. The reaction chamber includes a plurality of electrodes which cross each other and are separated by a dielectric to generate an electric field and a vibrating part agitating the magnetic beads in the chamber. The laser source radiates a laser onto the magnetic beads in the reaction chamber. | 2011-06-16 |
20110143415 | REPROGRAMMING NORMAL AND CANCEROUS HUMAN CELL LINES INTO HUMAN INDUCED POLURIPOTENT STEM CELLS BY CO-ELECTROPORATION WITH LIVING XENOPUS LAEVIS FROG OOCYTES - Using electroporation, it is possible to activate the natural reprogramming potential of living | 2011-06-16 |
20110143416 | STABILIZATION OF DEHYDROGENASES WITH STABLE COENZYMES - The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes. | 2011-06-16 |