22nd week of 2010 patent applcation highlights part 45 |
Patent application number | Title | Published |
20100136485 | ACETAL COMPOUNDS AND THEIR PREPARATION, POLYMERS, RESIST COMPOSITIONS AND PATTERNING PROCESS - An acetal compound of formula (1) is provided wherein R | 2010-06-03 |
20100136486 | RESIST PROTECTIVE COATING COMPOSITON AND PATTERNING PROCESS - A protective coating composition comprising a polymer of acyl-protected hexafluoroalcohol structure as a base polymer, optionally in admixture with a second polymer containing sulfonic acid amine salt in recurring units is applied onto a resist film. The protective coating is transparent to radiation of wavelength up to 200 nm. | 2010-06-03 |
20100136487 | PATTERN FORMATION METHOD USING LEVENSON-TYPE MASK AND METHOD OF MANUFACTURING LEVENSON-TYPE MASK - A method of forming a pattern including a first pattern portion having a first minimum dimension and a second pattern portion having a second minimum dimension includes a first exposure step of performing exposure using a Levenson-type mask and a second exposure step of performing exposure using a half tone-type mask. When second minimum dimension is 1.3 time or more than the first minimum dimension, the exposure amount of the second exposure step is set to be equal to or smaller than the exposure amount of the first exposure step. | 2010-06-03 |
20100136488 | PATTERN CREATION METHOD, SEMICONDUCTOR DEVICE MANUFACTURING METHOD, AND COMPUTER-READABLE STORAGE MEDIUM - A pattern creation method has extracting a first pattern and a second pattern which are different from each other from among first mask patterns created based on a first design pattern, calculating a best focus difference between the first pattern and the second pattern based on first exposure conditions, comparing the best focus difference to a predetermined threshold value, and if the best focus difference is larger than the threshold value, correcting the first design pattern to create a second design pattern. | 2010-06-03 |
20100136489 | MANUFACTURING DEVICE AND MANUFACTURING METHOD FOR POLYMER WAVEGUIDE DEVICE - A manufacturing device and a manufacturing method for polymer waveguide devices are revealed. The manufacturing device includes a substrate coated with a photoresist polymer membrane and set on a work platform, a femtosecond laser emitting onto the photoresist polymer membrane, and a lens arranged between the femtosecond laser and the substrate. The polymer waveguide devices are obtained by the femtosecond laser emitting onto the photoresist polymer membrane. Without complicated manufacturing processes, the production efficiency of the polymer waveguide devices is increased. | 2010-06-03 |
20100136490 | MULTI-SCALE CANTILEVER STRUCTURES HAVING NANO SIZED HOLES AND METHOD OF PREPARING THE SAME - Provided are a multi-scale cantilever structure having nano-sized holes prepared by anodic oxidation and a method of preparing the same. The multi-scale cantilever structure is prepared using anodic oxidation and electro-polishing so that a manufacturing process is simple and a manufacturing cost is inexpensive. In addition, the multi-scale cantilever structure has a porous structure having a plurality of nano-sized holes inside thereof, and thus a surface area of the cantilever structure can be maximized. Therefore, when the cantilever structure is used in a sensor, the sensor can have improved sensitivity and selectivity. | 2010-06-03 |
20100136491 | OXIME ESTER PHOTOINITIATORS - Compounds of formula (I), (II), and (III), wherein R | 2010-06-03 |
20100136492 | SUBSTRATE PROCESSING APPARATUS AND SUBSTRATE PROCESSING METHOD - A method of processing a substrate in a substrate processing apparatus that is arranged adjacent to an exposure device and includes first, second and third processing units, includes the steps of: forming a photosensitive film made of a photosensitive material on the substrate by said first processing unit before exposure processing by said exposure device. The method also includes applying washing processing to the substrate by said second processing unit after the formation of said photosensitive film by said first processing unit and before the exposure processing by said exposure device and transporting the substrate after the washing processing to said exposure device. The method further includes transporting the substrate from said exposure device and applying development processing by said third processing unit to the substrate transported after the exposure processing by said exposure device. | 2010-06-03 |
20100136493 | LOW NOx COMBUSTION APPARATUS - Prvided is a catalyst degradation preventing apparatus of a catalyst device containing a catalyst component that comes into contact with gas to chemically change the gas, including a burner for burning a fuel by combustible air to generate a gas containing nitrogen oxides by combustion, an endothermic device for absorbing heat from gas, a catalyst device having a catalyst component for decreasing nitrogen oxides contained in the gas after passing through the endothermic device, and a first poisoning substance removing device for removing a poisoning substance containing at least sulfur, which is contained in the fuel and adsorbs to a catalyst component or reacts with the catalyst component to form a compound. According to the apparatus, the decrease in performance of the catalyst device is prevented, and the effect of decreasing pollution can be retained over a long period of time. | 2010-06-03 |
20100136494 | COMBINED LIGHTER AND CIGARETTE PAPER DISPENSER - A combined lighter and cigarette paper dispenser comprises an elongated housing having an ignition mechanism fitted to one end. The housing includes a lighter fluid container | 2010-06-03 |
20100136495 | One-handed fire starter - A novel mechanical spark generating device for one-handed operation. The novel mechanical spark generating device includes a case having a case body and a relatively moveable striker arm extended therefrom, the case body includes a channel having an opening thereinto. A pyrophoric rod assembly is moveably carried in the channel of the case body, the pyrophoric rod assembly having a support surface adjacent to one end thereof, and a pyrophoric rod carried therein. A striker bar is fixed to the striker arm in a position for interacting with the pyrophoric rod of the pyrophoric rod assembly when the pyrophoric rod assembly is in a deployed configuration extended from the case body and the striker arm is moved there toward. | 2010-06-03 |
20100136496 | COMBUSTOR - A combustor, in which a flame holding region is formed at a location distant from a pilot burner to avoid burnout of the pilot burner and in which flame holding capability is increased to use a lean pre-mix gas for reducing NOx emission, is provided. The combustor includes a combustion liner having a cylindrical side wall that defines a combustion chamber; and a main burner positioned at a top portion of the combustion liner for injecting an annular pre-mix gas into the combustion chamber to form a reverse flow region at a downstream portion thereof, which region is oriented towards the top portion of the combustion chamber along a longitudinal axis. In this combustor, a pilot burner is arranged at the top portion for injecting a mixture of fuel and air only in a direction confronting the reverse flow region. | 2010-06-03 |
20100136497 | ADJUSTABLE SPACE RETAINER AND REGAINER - This invention is related to easily maintain the mesio-distal dimension of the lost deciduous tooth and at the same time providing the appliance to be adjusted to any posterior space even at the first visit. If necessary it can also re-gain the lost space. The apparatus can be manufactured of Cr-Ni, titanium or similar metals. The appliances has two bondable surfaces to bond the appliance to the buccal surfaces of the teeth adjacent to the extraction space, the anterior and posterior vertical connecting arms extending from these surfaces to the vestibular side of the teeth, adjusted to the dental and gingival contours. The posterior tubular arm conforming to its name possesses two. The thinner one which is soldered at the bottom of the front side is called the “guide tube” and it has wider internal diameter than the other tube. While gaining space, it guides the “anterior piston arm” directly to the second tube of the “posterior tubular arm”, when these two arms are angulated due to the bended adjacent teeth. | 2010-06-03 |
20100136498 | Mouthpiece Devices and Methods to Allow UV Whitening of Teeth - A plastic mouthpiece insert for allowing a wearer to whiten their teeth while getting a suntan, and have a generally oblong oval-rectangular opening with a curved rear end that abuts against the root surfaces of the frontal upper and lower teeth of the wearer. A raised front edge can protect the lips and separate in place about the opening to the mouthpiece. Whitening agents can be used to enhance the whitening effect so that ultraviolet light and heat source such as the sun or a sunlamp is all that it is needed. Reflective inner walls in the mouthpiece can magnify light to the teeth. The mouthpiece can include bite tables, and the side walls of the mouthpiece can be inwardly flared and funnel shaped for focusing and magnifying incoming light and heat. The mouthpiece can be colored to protect the inside of the wearer's mouth from receiving any light. An attachable *and detachable compact hands-free light source can also be used. The light source can clip on the front of the mouthguard so that the mouthguard can allow for teeth whitening without the need for a suntanning lamp or use of the sun or other exterior light sources. The attached light source allows the user to use the mouthguard and not be restricted to staying in one place. With the attached light source the user is free to use both their hands and do all other types of activities and be able to freely move around. | 2010-06-03 |
20100136499 | DEVICE FOR STORING AND DISPENSING COMPOSITIONS - The present invention includes a device that includes a receptacle integrated with a mounting portion. The mounting portion is generally sized to fit, for example, over a portion of the user's body, providing convenient access to material in the receptacle during the application of the material to a surface. In some embodiments, a flexible connection connects the mounting portion and the receptacle. In other embodiments, the device includes at least two flexible mounting portions and, optionally, a fastener system. | 2010-06-03 |
20100136500 | DRILL SLEEVE FOR A DENTAL DRILL - Drill sleeve ( | 2010-06-03 |
20100136501 | RELEASABLE PLUG CONNECTION CONSISTING OF TWO COMPONENTS, NAMELY A JACK AND A PLUG, AS WELL AS A JACK AND A NOZZLE TUBE FORMING A PLUG - The invention relates to a releasable plug connection, for inserting a nozzle tube ( | 2010-06-03 |
20100136502 | MEDICINAL IMPLANT DEVICE AND CARTRIDGE - The invention includes a device for inserting a medicament within a body cavity of a mammal, and a cartridge for containing the medicament within the device, where the cartridge includes a housing, a retractable chamber for containing medicament disposed within the housing, and a substantially stationary member disposed within the barrel of the retractable chamber, where upon activation of the device, the retractable chamber is retracted about the substantially stationary member, thereby depositing medicament within the body cavity. | 2010-06-03 |
20100136503 | MEDICAL OR DENTAL HANDPIECE HAVING A BEARING ARRANGEMENT FOR A ROTARY PART - The medical or dental handpiece comprises a rotary part and at least one roller bearing which is provided for bearing support of the rotary part. The roller bearing has a bearing inner ring and a bearing outer ring, each having a raceway for the at least one rolling element arranged therebetween. The rotary part is mounted on at least one bearing ring on the side having the raceway for the at least one rolling element. | 2010-06-03 |
20100136504 | DUAL OPTION ORTHODONTIC IMPLANT DRIVER FOR PLACING AND TIGHTENING IMPLANTS - The present invention embodies an apparatus and method to drive an orthodontic implant while minimizing the risk of damaging the implant. More specifically, a dual option driver ( | 2010-06-03 |
20100136505 | SHELL PLATE FOR ARTIFICIAL TEETH WITH ARRANGEMENT ASSISTING FUNCTION - An artificial teeth packaging container | 2010-06-03 |
20100136506 | METHOD OF FABRICATING IMPLANT WITH IMPROVED SURFACE PROPERTIES AND IMPLANT FABRICATED BY THE SAME METHOD - A method of fabricating an implant with improved surface properties and an implant fabricated using the same are provided. The method includes immersing a substrate that has titanium or titanium alloy in electrolytic solution including at least one of the group consisting of phosphate or fluoride ion and strontium ion, and forming an oxide film layer with a surface structure having a fine roughness of a micro scale by making at least one of phosphate or fluoride ion and strontium ion react to the titanium or the titanium alloy of the substrate on a surface of the immersed substrate using hydrothermal reaction associated with temperature, pressure and time conditions. | 2010-06-03 |
20100136507 | DRIVING SIMULATION APPARATUS, WIDE-ANGLE CAMERA VIDEO SIMULATION APPARATUS, AND IMAGE DEFORMING/COMPOSITING APPARATUS - A driving simulation apparatus includes an input unit that receives an input of an operation instruction, a vehicle simulation unit that calculates a position and an orientation of a vehicle in a virtual environment in real-time, a camera state calculation unit that calculates a viewpoint position and a viewing direction of a on-vehicle wide-angle camera based on the position and the orientation of the vehicle, and a wide-angle camera simulation unit. The wide-angle camera simulation unit includes an intermediate image rendering unit that generates multiple intermediate images by, for multiple intermediate projection planes that cover a given field of view from the on-vehicle wide-angle camera, performing perspective projection on the virtual environment from the viewpoint position and the viewing direction of the on-vehicle wide-angle camera, and a video rendering unit that generates a on-vehicle wide-angle camera video by deforming and compositing the intermediate images based on a parameter generated based on a lens characteristic of the on-vehicle wide-angle camera that has been recorded in advance. | 2010-06-03 |
20100136508 | Meal Plan Management - A meal plan is generated based on user health data, goals and other information. The data regarding user health goals, eating habits, current health condition, and eating preferences is accessed. A user meal plan is then generated based on at least a portion of the accessed information. The meal plan may be modified based on user selected substitutions, automatically generated substitutions, or in some other manner. When the meal plan is modified, information related to the meal plan is updated. | 2010-06-03 |
20100136509 | SYSTEM AND METHOD FOR CLINICAL TRIAL INVESTIGATOR MEETING DELIVERY AND TRAINING INCLUDING DYNAMIC MEDIA ENRICHMENT - A System and Method for Delivering the substantive equivalent of an Investigator Meeting for Clinical Tπals to satisfy Investigator Site training requirements sufficient to commence patient enrollment is provided The invention further provides a means to ensure site personnel receive, review and implement Protocol Amendments in a timely and comprehensive manner The preferred embodiment includes a mechanism to track and verify actual viewing of compulsory material The invention further provides for dynamically supplementing the online presentation with content enrichment In the preferred embodiment, user questions are submitted during user viewing of online media An Administrator processes user inputs, including questions, and answers attached to the presentation at the time point at which the question/comment was generated Subsequent users/viewers are alerted to the added commentary by an icon on the display during viewing of presentation media, enabling them to benefit from questions and answers associated with the media. | 2010-06-03 |
20100136510 | JOINT REPLICA MODELS AND METHODS OF USING SAME FOR TESTING MEDICAL DEVICES - Disclosed herein are joint replica models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of complexity that allows them to be substituted for either a live animal, an animal cadaver, or a human cadaver in the testing of these devices. These models are further characterized by a similarity of geometry, individual component physical properties, and component-to-component interfacial properties with the appropriate target tissue and anatomy. | 2010-06-03 |
20100136511 | System and Method for Teaching a Musical Instrument - A system for teaching a musical instrument includes an electronic keyboard. A computer is in communication with the electronic keyboard. A lessons and tracking server communicates over a network to the computer. The lessons and tracking server has a lessons module that serves up a lesson to the computer. The computer scores a student's performance and transmits a score to the lessons and tracking server. | 2010-06-03 |
20100136512 | EMBRYO CULTURE MEDIA CONTAINING THYROID HORMONE - The disclosure relates to the use of culture media containing thyroid hormones or analogs thereof, and includes methods and uses thereof for embryo culture, embryo production, embryo maturation, improved survival of embryos and improved viability of embryos post cryopreservation. | 2010-06-03 |
20100136513 | Assay for sars coronavirus by amplification and detection of nucleocapsid rna sequence - Primers and probes derived from SARS-CoV nucleic acid that facilitate detection and/or quantification of the nucleocapsid gene are disclosed. The disclosed sequences may be used in a variety of amplification and non-amplification formats for detection of SARSCoV infection. | 2010-06-03 |
20100136514 | INFECTIOUS CLONE OF HUMAN PARVOVIRUS B19 AND METHODS - The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections. | 2010-06-03 |
20100136515 | COMPOSITIONS FOR USE IN IDENTIFICATION OF PAPILLOMAVIRUS - The present invention relates generally to identification of HPV, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis. | 2010-06-03 |
20100136516 | System and method for detection of HIV integrase variants - An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with integrase is described that comprises the steps of: (a) generating a cDNA species from a plurality of RNA molecules in an HIV sample population; (b) amplifying a plurality of first amplicons from the cDNA species, wherein each first amplicon is amplified with a pair of nucleic acid primers; (c) clonally amplifying the amplified copies of the first amplicons to produce a plurality of second amplicons; (d) determining a nucleic acid sequence composition of the second amplicons; (e) detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic acid sequence composition of the second amplicons; and (f) correlating the detected sequence variants with variation associated with HIV integrase. | 2010-06-03 |
20100136517 | MATRIX STABILIZATION OF AGGREGATION-BASED ASSAYS - Methods and apparatus for stabilization of aggregation-based assays are described. In various embodiments, anti-analytes are dispersed within a matrix. A solution containing analytes brought into contact with the matrix, so that analytes may permeate throughout at least a portion of the matrix. In some embodiments, the anti-analytes and analytes are mobile within the matrix. As aggregates form and increase in size, the aggregates become substantially immobile within the matrix. As a result, signals representative of an amount of aggregation within the matrix can remain substantially constant. In various aspects, matrix-stabilized aggregation-based assays provide for reliable quantitative analysis of analyte concentration with test solutions. | 2010-06-03 |
20100136518 | ANTIBODIES USEFUL FOR THERAPY AND DIAGNOSIS OF CANCER - The present invention provides antibodies, or fragments thereof, for isolating and/or identifying epitopes of an endogenous retrovirus, preferably of a melanoma associated endogenous retrovirus, and hybridoma cells producing said antibodies. The antibodies are useful especially for the treatment and diagnosis of cancer. Further, the present application covers diagnostic kits for the detection of cancer cells, especially of melanoma cells and methods for cancer diagnosis using said antibodies. | 2010-06-03 |
20100136519 | Determination of a specific immunoglobulin using multiple antigens - The invention concerns a process for the immunological determination of a specific antibody in a fluid sample. The process involves incubating the fluid sample in the presence of a solid phase with two antigens directed against the antibody whose presence is to be determined; the first antigen carries at least one marker group, while the second is either (a) bonded to the solid phase or (b) present in a form in which it can bond with the solid phase, and betrays the presence of the antibody being sought by showing the presence of the marker group in the solid phase and/or in the fluid phase. The proposed process is characterised by the fact that at least one of the two antigens has several epitopic regions which react with the antibody to be determined. | 2010-06-03 |
20100136520 | DETECTING HEPATITIS B VIRUS - This invention is related to methods for detecting hepatitis B virus by determining the level of hepatitis B virus surface antigen protein. This invention is also related to methods for detecting mutant hepatitis B virus surface antigen protein and kits for detecting hepatitis B virus. | 2010-06-03 |
20100136521 | Devices And Methods For Detection Of Microorganisms - The present invention features methods and devices for microorganisms through detecting Mie light scattering from immunoagglutinated beads. The methods feature providing a first bead suspension with antibody specific for the microorganism conjugated to beads; mixing the first bead suspension with a sample to form a first mixture; irradiating the first mixture with first incident light; detecting forward light scattering at a first angle with respect to the first incident light, where the first angle being between about 30 to 60 degrees; determining l from the light scattering; providing a second bead suspension with no antibody and simultaneously measuring l | 2010-06-03 |
20100136522 | ENDOGENOUS RETROVIRUSES UP-REGULATED IN PROSTATE CANCER - Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy. | 2010-06-03 |
20100136523 | Molecular signature and assay for fluoroquinoline resistance in bacillus anthracis - The preferred therapeutic for human anthrax infections are therapeutics from the fluoroquinolone class, in particular, Ciprofloxacin (CIP). This invention discloses the molecular basis for fluoroquinolone (CEP in particular) action and provides the molecular signatures which form the basis of diagnostic assays. This invention further discloses nucleotide signatures associated with CIP-resistance are useful in diagnostic tests to rapidly identify CIP resistant | 2010-06-03 |
20100136524 | TARGET PROTEIN AND TARGET GENE IN DRUG DESIGNING AND SCREENING METHOD - The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like. | 2010-06-03 |
20100136525 | FLUID ANALYSIS DEVICE AND METHOD - The invention provides an analysis device ( | 2010-06-03 |
20100136526 | Therapeutic Agent for Neuroblastoma Targeting ARID3b - It is intended to provide a therapeutic agent for neuroblastoma. More particularly, it is intended to provide the therapeutic agent for neuroblastoma containing an ARID3b inhibitor. | 2010-06-03 |
20100136527 | Dominant B Cell Epitopes and Methods of Making and Using Thereof - Disclosed are methods for obtaining at least one epitope suitable for detecting the presence of an antibody against a tumor associated antigen of a cancer in a sample. Kits, assays, and substrates employing the epitopes of the present invention are disclosed. Also disclosed are epitopes of NY-ESO-1 and XAGE-1b and methods of using thereof. | 2010-06-03 |
20100136528 | FIAT NUCLEIC ACIDS AND PROTEINS AND USES THEREOF - The invention provides FIAT nucleic acids and proteins, and methods of using such nucleic acids and proteins. | 2010-06-03 |
20100136529 | Rare cell analysis using sample splitting and DNA tags - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample. | 2010-06-03 |
20100136530 | PROBE, PROBE SET, PROBE-IMMOBILIZED CARRIER, AND GENETIC TESTING METHOD - A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 62 to 64 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium. | 2010-06-03 |
20100136531 | NUCLEIC ACID DETECTION USING LATERAL FLOW METHODS - Methods and kits for use in detecting a target nucleic acid in a sample are disclosed. In one particular application, the methods and kits allow for the detection of an undesirable micro-organism (e.g. | 2010-06-03 |
20100136532 | AQP5 Polymorphism - In order to predict disease risks, disease courses and the response of an individual patient to pharmacological and non-pharmacological therapies a polymorphism in the AQP5 gene has been investigated, in particular in the promoter region of said gene,on the human 12q13 chromosome, wherein the therapy can also be a cosmetic treatment. | 2010-06-03 |
20100136533 | COMPOUND CONTAINING FARNESYL DIPHOSPHATE FOR MODULATING TRPV3 FUNCTION AND USE THEREOF - The present invention relates to a method for activating TRPV3 (transient receptor potential vanilloid 3) using FPP (farnesyl diphosphate) and a method for screening a TRPV3 activity inhibitor. FPP of the present invention has TRPV3 specific activity and therefore it can be effectively used for the study on TRPV3 mechanism and functions and for the development of a TRPV3 based pain reliever. | 2010-06-03 |
20100136534 | METHOD OF IDENTIFIYING A SEROTYPE OF KLEBSIELLA PNEUMONIAE AND APPLICATION THEREOF - The present invention relates to a method of identifying a serotype of | 2010-06-03 |
20100136535 | MEANS AND METHODS FOR DETECTING PROTEIN-PEPTIDE INTERACTIONS - A novel method of detecting and characterizing protein-peptide interactions is provided, which can be used for isolating peptides and proteins, respectively, as well as in drug screening and development. | 2010-06-03 |
20100136536 | Molecular Switches And Methods For Their Use - The present invention relates to compositions and methods that allow the manipulation of the catalytic activity of multi-component nucleic acid complexes. Further, the invention provides methods which use these compositions and methods to create molecular sensors, molecular switches, and/or modulators or propagators of autocatalytic self-replicating cascades and other iterative processes. More particularly, the invention relates to compositions allowing self-assembly of active and inactive multicomponent nucleic acid complexes, methods of making such compositions, and methods for use. | 2010-06-03 |
20100136537 | PHOTORECEPTOR PRECURSOR CELLS - The present invention relates to photoreceptor cells. In particular, the present invention provides photoreceptor cells comprising heterologous nucleic acid sequences and transgenic animals comprising the same. The present invention also provides photoreceptor precursor cells (e.g., rod photoreceptor precursor cells), and methods of identifying, characterizing, isolating and utilizing the same. Compositions and methods of the present invention find use in, among other things, research, clinical, diagnostic, drug discovery, and therapeutic applications. | 2010-06-03 |
20100136538 | MARKING REAGENTS BEARING DIAZO AND NITRO FUNCTIONS, METHODS FOR THE SYNTHESIS OF SUCH REAGENTS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES - The present invention relates to a labeling reagent of formula: | 2010-06-03 |
20100136539 | EZRIN ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - A method for the in vitro diagnosis of colorectal cancer by determining the presence of the Ezrin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-Ezrin monoclonal antibody directed against an Ezrin epitope chosen from the epitopes of sequence SEQ ID No.1, SEQ ID No.2, SEQ ID No.3, SEQ ID No.4+SEQ ID No.5, SEQ ID No.6+SEQ ID No.7 and SEQ ID No.8. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer. | 2010-06-03 |
20100136540 | Methods and compositions for characterizing patients for clinical outcome trials - The invention provides with methods for characterizing and selecting, within a population of subjects with type-2 diabetes, subjects that are suited for clinical trials based on the identification of one or more genetic features, which are single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), and/or other genomic markers. The invention further involves characterizing these subjects based on the probability of developing complications related to type-2 diabetes, such as, myocardial infarction, stroke and albuminuria. Also described are combinations and kits for carrying out the above-described methods. | 2010-06-03 |
20100136541 | IDENTIFICATION AND VERIFICATION OF METHYLATION MARKER SEQUENCES - The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also provides methods of using the selected CpG sites for purposes of diagnosis, prognosis, staging, assessing or monitoring the therapy of or recovery from a disease such as cancer. | 2010-06-03 |
20100136542 | NUCLEIC ACID AMPLIFICATION AND TESTING - Methods for amplifying a target nucleic acid by self-sustained amplification methods are described. The methods are designed, in particular, to be carried out without use of specialised lab facilities or instruments. Compositions, lyophilised formulations, and kits for carrying out the methods are also described. | 2010-06-03 |
20100136543 | METHOD FOR DETERMINING THE GENOTYPE AT THE CROHN'S DISEASE LOCUS - The present invention refers to a method for determining the genotype of an individual at the 5p13.1 Crohn's disease risk locus, the method comprising: providing a sample from the individual; determining whether a DNA sequence corresponding to a DNA sequence polymorphism located between coordinated 40,300,000 and 40,600,000 of human chromosome (coordinates corresponding to the march 2006 assembly of the human genome) is present in the sample; and determining the nature of the DNA sequence polymorphism genotype located between coordinated 40,300,000 and 40,600,000 of human chromosome as it relates to the genetic risk to develop Crohn's disease. | 2010-06-03 |
20100136544 | ASSAYS AND OTHER REACTIONS INVOLVING DROPLETS - The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel. In some aspects, a heterogeneous assay can be performed using a gel. For example, a droplet may be hardened to form a gel, where the droplet contains a cell, DNA, or other suitable species. The gel may be exposed to a reactant, and the reactant may interact with the gel and/or with the cell, DNA, etc., in some fashion. For example, the reactant may diffuse through the gel, or the hardened particle may liquefy to form a liquid state, allowing the reactant to interact with the cell. As a specific example, DNA contained within a gel particle may be subjected to PCR (polymerase chain reaction) amplification, e.g., by using PCR primers able to bind to the gel as it forms. As the DNA is amplified using PCR, some of the DNA will be bound to the gel via the PCR primer. After the PCR reaction, unbound DNA may be removed from the gel, e.g., via diffusion or washing. Thus, a gel particle having bound DNA may be formed in one embodiment of the invention. | 2010-06-03 |
20100136545 | Cytokines and Genes Differentially Affected by TNF Blockers - The present invention is directed to cytokines and genes that are differentially affected by TNF blockers and the use of these genes and cytokines to help asses the TB risks of new immunosuppressive therapies, to help evaluate the effects of new TB vaccines, and to help assess TB susceptibility in persons exposed to | 2010-06-03 |
20100136546 | GENETIC MARKER FOR ADVERSE BEHAVIORAL CONDITIONS - The present invention concerns genetic marker for adverse behavioral conditions. In particular aspects, the marker is present at chromosome 15q13 and comprises CHRNA7. In certain cases, the marker is a microdeletion or point mutation in CHRNA7. | 2010-06-03 |
20100136547 | Pure miRNA Sample Preparation Method - The present teachings provide novel methods, compositions, and kits for analyzing mature micro RNAs (miRNAs). By taking advantage of the observation that most mature miRNAs in cells are tightly associated with RISCs, the present teachings provide approaches for studying mature miRNAs without the complications of additional nucleic acids. For example, in some embodiments the present teachings provide a method of purifying mature miRNAs comprising heating a sample to form a lysate, and, degrading the additional nucleic acids. The resulting mixture lacks the additional nucleic acids, and contains mature miRNAs associated with RISCs. Liberating the mature miRNAs from RISCs, for example by a protease, a detergent, and/or heat, can result in a pure collection of mature miRNAs. | 2010-06-03 |
20100136548 | METHODS AND COMPOSITIONS FOR ORDERING RESTRICTION FRAGMENTS - The invention relates to methods and systems for sequencing and constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are determined at the ends of restriction fragments produced by a plurality of digestions with a plurality of combinations of restriction endonucleases so that a pair of nucleotide sequences is obtained for each restriction fragment. A physical map of the polynucleotide is constructed by ordering the pairs of sequences by matching the identical sequences among the pairs. | 2010-06-03 |
20100136549 | REPRODUCIBLE QUANTIFICATION OF BIOMARKER EXPRESSION - A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator. | 2010-06-03 |
20100136550 | Methods and Compounds for the Diagnosis of Inflammatory Disease and Identification of Pharmacological Agents Useful in the Treatment of Inflammatory Disease - Methods for the diagnosis of inflammatory bowel diseases and the identification of agents useful in the treatment of such diseases based upon the agent's effect on reducing Pim-2 expression. | 2010-06-03 |
20100136551 | MICROFLUIDIC PLATFORM AND RELATED METHODS AND SYSTEMS - A microfluidic platform comprising one or more chambers connectable through microfluidic channels, and comprising a substrate presenting aptamer sensors detectable through Raman active molecules, and related methods and systems. | 2010-06-03 |
20100136552 | Methods and compositions for DMXL-associated mental retardation - The present invention provides a method of identifying a human subject as having an increased likelihood of having DMXL-associated mental retardation, comprising detecting, in a nucleic acid sample from the subject, a mutation in a nucleotide sequence encoding DMXL1 and/or a mutation in a nucleotide sequence encoding DMXL2. The present invention further provides a method of identifying a human subject as having an increased likelihood of having DMXL-associated mental retardation, comprising detecting, in a sample from the subject, a mutation in a DMXL1 protein and/or a mutation in a DMXL2 protein. | 2010-06-03 |
20100136553 | Prognosis prediction for melanoma cancer - The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer. | 2010-06-03 |
20100136554 | SUPPORTED REAGENTS, METHODS, AND DEVICES - Methods of providing at least one reagent for use in a device for processing sample material, delivering at least one reagent to a device for processing sample material, and adding at least one reagent to at least one of the steps in a process for detecting or assaying a nucleic acid; a support film coated with a dry reagent layer; and a device for processing sample material having a support film coated with a dry reagent layer contained within at least one chamber of the device are disclosed. | 2010-06-03 |
20100136555 | Burkholderia Pseudomallei Diagnostic Genetic Elements that Predict Mortality in Melioidosis - The present invention provides methods for predicting the likelihood of mortality from melioidosis and detecting the presence of | 2010-06-03 |
20100136556 | DETECTION DEVICE FOR DETECTING BIOLOGICAL MICROPARTICLES SUCH AS BACTERIA, VIRUSES, SPORES, POLLEN OR BIOLOGICAL TOXINS, AND DETECTION METHOD - A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be examined is passed over a filter to filter out the micro particles and to perform the marking steps by supplying corresponding marking substances to the filter. | 2010-06-03 |
20100136557 | Methods and Compositions for Isolating Nucleic Acid Sequence Variants - The invention is drawn to isolating sequence variants of a genetic locus of interest using a modified iterative primer extension method. The nucleic acids analyzed are generally single stranded and have a reference sequence which is used as a basis for performing iterative single nucleotide extension reactions from a hybridized polymerization primer. The iterative polymerization reactions are configured such that polymerization of the strand will continue if the sequence of the nucleic acid being analyzed matches the reference sequence, whereas polymerization will be terminated if the nucleic acid being analyzed does not match the reference sequence. Nucleic acid strands that have mutations can be isolated using a variety of methods and sequenced to determine the precise identity of the mutation/polymorphism. By performing the method on both strands of the nucleic acid being analyzed, virtually all possible mutations can be identified. | 2010-06-03 |
20100136558 | CANINE CD20 GENE - It is intended to clarify the CD20 amino acid sequence and its gene sequence which are essentially required in constructing an anti-CD20 antibody useful in treating animal malignant lymphoma. It is also intended to provide a method of diagnosing canine malignant lymphoma by using the CD20 gene sequence. Using monocytes in canine blood as a sample, mRNA is obtained and the full base sequence of canine CD20 gene (SEQ ID NO:2) is determined. Based on this sequence, its amino acid sequence (SEQ ID NO:1) is determined. Comparing the homologies with human and mouse CD20 genes and amino acid sequences, it is identified as canine CD20 gene. Moreover, a primer specific to the canine CD20 gene is constructed and the expression of the CD20 gene in a sample is examined, thereby giving a method of diagnosing canine B lymphocyte-origin malignant lymphoma. | 2010-06-03 |
20100136559 | CHROMATIN STRUCTURE DETECTION - The present application provides methods and compositions for determining accessibility of a DNA modifying agent in genomic DNA. | 2010-06-03 |
20100136560 | Integrated Analyses of Breast and Colorectal Cancers - Genome-wide analysis of copy number changes in breast and colorectal tumors used approaches that can reliably detect homozygous deletions and amplifications. The number of genes altered by major copy number changes—deletion of all copies or amplification of at least twelve copies per cell—averaged thirteen per tumor. These data were integrated with previous mutation analyses of the Reference Sequence genes in these same tumor types to identify genes and cellular pathways affected by both copy number changes and point alterations. Pathways enriched for genetic alterations include those controlling cell adhesion, intracellular signaling, DNA topological change, and cell cycle control. These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that are useful for cancer diagnosis and therapy. | 2010-06-03 |
20100136561 | Genetic Markers for Weight Management and Methods of Use Thereof - This application relates to methods and tests that allow for the establishment of personalized weight-loss programs for a subject based upon the subject's metabolic genotype in key metabolic genes. Kits and methods are disclosed for determining a subject's metabolic genotype, which may be used to select an appropriate therapeutic/dietary regimen or lifestyle recommendation based upon the likelihood of a subject's responsiveness to certain diets and activity levels. Such a personalized weight-loss program will have obvious benefits (e.g., yield better results in terms of weight loss and weight maintenance) over traditional weight-loss programs that do not take into account genetic information. | 2010-06-03 |
20100136562 | Multivariate Analysis Involving Genetic Polymorphisms Related To Mediators Of Inflammatory Response For Prediction Of Outcome Of Critcally Ill Patients - A method of using genetic polymorphisms related to pro-inflammatory mediators to predict clinical outcome in critically ill patients admitted to an ICU is provided. | 2010-06-03 |
20100136563 | SYSTEM AND METHOD FOR NUCLEIC ACIDS CONTAINING FLUID PROCESSING - A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device magnetically separates the particles. The heating and separating devices move into at least one operative position for processing the fluids and at least one inoperative position with respect to the containers, in which the containers are kept stationary at least during and in-between incubating the fluids and manipulating the magnetically responsive particles. | 2010-06-03 |
20100136564 | STEROID RESPONSIVE NUCLEIC ACID EXPRESSION AND PREDICTION OF DISEASE ACTIVITY - The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection. | 2010-06-03 |
20100136565 | Compositions and Methods for Diagnosing Autism - Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related disorders. Thus, the present invention relates to compositions in the form of diagnostic kits, primers and target sequences, for use in methods for determining the predisposition, the onset or the presence of autism spectrum disorder in a mammal. Moreover, therapeutic methods for treating a person inflicted with, or predisposed to, an autism spectrum disorder based upon modulating the level or activity of EN2 are also provided. | 2010-06-03 |
20100136566 | LATERAL FLOW STRIP ASSAY WITH IMMOBILIZED CONJUGATE - The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the devices are also described. | 2010-06-03 |
20100136567 | CYANINE DYES - The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. | 2010-06-03 |
20100136568 | Compositions and Methods for Regulating RNA Translation via CD154 CA-Dinucleotide Repeat - Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of hnRNP L with the CA-dinucleotide rich sequence of the 3′-untranslated region of CD154. | 2010-06-03 |
20100136569 | COMPOSITIONS, METHODS AND KITS FOR POLYNUCLEOTIDE AMPLIFICATION REACTIONS AND MICROFLUIDIC DEVICES - Antifoam agents improve detection of polynucleotide amplification reactions and improve manipulation of fluids in microfluidic devices. | 2010-06-03 |
20100136570 | SENSITIVE AND RAPID DETERMINATION OF ANTIMICROBIAL SUSCEPTIBILITY - The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials. | 2010-06-03 |
20100136571 | I-PLASTIN ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - A method for the in vitro diagnosis of colorectal cancer by determining the presence of the I-Plastin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer. | 2010-06-03 |
20100136572 | METHOD OF ASSAYING APOLIPOPROTEIN AI FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER - The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Apolipoprotein AI tumor marker in a biological sample taken from a patient suspected of having colorectal cancer, it being understood that the assay is not turbidimetric. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis in relation to colorectal cancer. | 2010-06-03 |
20100136573 | DIAGNOSING NEURODEGENERATIVE DISEASES - This document provides methods and materials related to determining whether or not a mammal (e.g., a human) has a neurodegenerative disease (e.g., frontotemporal dementia, AD, or amyotrophic lateral sclerosis (ALS)). For example, methods and materials for using the levels of TDP-43 polypeptides and/or TDP-43 polypeptide cleavage products (e.g., 25 kD and 35 kD TDP-43 polypeptide cleavage products) in a biological fluid (e.g., cerebrospinal fluid) to determine whether or not a mammal has a neurodegenerative disease (e.g., frontotemporal dementia, AD, or ALS) are provided. | 2010-06-03 |
20100136574 | METHOD FOR DETECTING A CHRONIC INFLAMMATORY-ASSOCIATED DISEASE - The present invention in one embodiment is an early detection marker for chronic or acute inflammatory-associated diseases. Chronic diseases may include atherosclerosis, Alzheimer's disease, asthma, rheumatoid arthritis, osteoarthritis, and inflammatory diseases of the bowel such as Crohn's disease, Ulcerative colitis, Irritable bowel syndrome and Inflammatory bowel disease. Acute diseases may include sepsis, acute systemic infections, acute lung injury, and acute respiratory distress syndrome. | 2010-06-03 |
20100136575 | B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 2010-06-03 |
20100136576 | In Vitro Method for Diagnosing Prostate Cancer - The invention relates to an in vitro method for diagnosing prostate cancer and to antibodies and fragments thereof directed against CK2-α and their use for the diagnosis and prognosis of prostate cancer. | 2010-06-03 |
20100136577 | COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF PROLIFERATIVE ABNORMALITIES ASSOCIATED WITH OVEREXPRESSION OF HUMAN TRANSKETOLASE LIKE-1 GENE - Methods for in vitro diagnosis of carcinoma are disclosed. In one aspect the invention relates to methods such as detecting the level of transketolase like-1 polypeptide, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides. | 2010-06-03 |
20100136578 | METHOD OF MEASURING THE ACTIVITY OF LIPID-MODIFIED ENZYME - It is intended to provide an assay method whereby the activity of a lipid-modifying enzyme can be conveniently measured over a wide range and a drug capable of controlling a lipid-modifying enzyme with the use of this assay method. The above problem can be solved by, for example, a method of measuring the activity of a lipid-modifying enzyme which comprises the steps of (I) preparing a lipid micelle containing a biotinylated lipid and a substrate for the lipid-modifying enzyme; (II) bringing the lipid micelle prepared in the above step (I) into contact with the lipid-modifying enzyme; and (III) evaluating the activity of the lipid-modifying enzyme by applying an evaluation method using the proximity effect to the product obtained in the above step (II). | 2010-06-03 |
20100136579 | BIOMARKERS USEFUL IN LIVER FIBROSIS DIAGNOSIS - Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis. | 2010-06-03 |
20100136580 | DISHEVELED PDZ MODULATORS - The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators. | 2010-06-03 |
20100136581 | DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS - The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH. | 2010-06-03 |
20100136582 | METHOD FOR IDENTIFICATION OF SOMATIC STEM CELLS - The invention relates to a method for identification of somatic stem cells, wherein the spatial arrangement of epitopes in a sample is captured by MELC technology for identifying the phenotype specific to the somatic stem cells. The invention moreover relates to a composition, a kit and a biochip comprising at least one antibody and/or ligand which can be employed for the performance of the method. | 2010-06-03 |
20100136583 | Method for Diagnosing Tumors by Measuring the Level of Apolipoprotein A-IV - Method for diagnosing a tumor in an individual comprising the following steps: —measuring the amount of apolipoprotein A-IV (ApoA-IV) in a body fluid sample or tissue sample of an individual, —comparing the measured amount of ApoA-IV in said sample with a reference value, wherein the reference value is the ApoA-IV content in a sample derived from an individual without a tumor, and —diagnosing a tumor if the ApoA-IV content in the sample is decreased compared to the reference value. | 2010-06-03 |
20100136584 | METHODS FOR USING ANTIBODIES AND ANALOGS THEREOF - Camelid and shark single-domain heavy chain antibodies lacking the light chains, and their analogs are disclosed. Methods for using the antibodies and their analogs to detect antigens are disclosed. Methods to derivatize such antibodies and analogs to develop diagnostic assays are described. Also provided are kits, and methods of using such diagnostics assays. | 2010-06-03 |